Genomes and Genes
Gene Symbol: Tnfsf11
Description: tumor necrosis factor (ligand) superfamily, member 11
Alias: Ly109l, ODF, OPGL, RANKL, Trance, tumor necrosis factor ligand superfamily member 11, OPG ligand, TNF-related activation-induced cytokine, osteoclast differentiation factor, osteoprotegerin ligand, receptor activator of NF-kappaB ligand, receptor activator of nuclear factor kappa-B ligand, tumor necrosis factor-related activation-induced cytokine
Publications149 found, 100 shown here
- TRANCE is a novel ligand of the tumor necrosis factor receptor family that activates c-Jun N-terminal kinase in T cellsB R Wong
The Rockefeller University, New York, New York 10021, USA
J Biol Chem 272:25190-4. 1997A novel member of the tumor necrosis factor (TNF) cytokine family, designated TRANCE, was cloned during a search for apoptosis-regulatory genes using a somatic cell genetic approach in T cell hybridomas...
- A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell functionD M Anderson
Department of Molecular Biology, Immunex Corporation, Seattle, Washington 98101, USA
Nature 390:175-9. 1997..of NF-kappaB), a new member of the TNFR family derived from dendritic cells, and the isolation of a RANK ligand (RANKL) by direct expression screening...
- TRANCE (tumor necrosis factor [TNF]-related activation-induced cytokine), a new TNF family member predominantly expressed in T cells, is a dendritic cell-specific survival factorB R Wong
Laboratory of Immunology, The Rockefeller University, New York 10021, USA
J Exp Med 186:2075-80. 1997b>TRANCE (tumor necrosis factor [TNF]-related activation-induced cytokine) is a new member of the TNF family that is induced upon T cell receptor engagement and activates c-Jun N-terminal kinase (JNK) after interaction with its putative ..
- Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKLH Yasuda
Research Institute of Life Science, Snow Brand Milk Products Co, Ltd, 519 Ishibashi machi, Shimotsuga gun, Tochigi 329 0512, Japan
Proc Natl Acad Sci U S A 95:3597-602. 1998..We conclude that the membrane-bound protein is osteoclast differentiation factor (ODF), a long-sought ligand mediating an essential signal to osteoclast progenitors for their ..
- Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activationD L Lacey
Department of Pathology, Amgen, Inc, Thousand Oaks, California 91320 1789, USA
Cell 93:165-76. 1998..b>OPG ligand (OPGL) binds to a unique hematopoeitic progenitor cell that is committed to the osteoclast lineage and ..
- OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesisY Y Kong
Amgen Institute, Department of Medical Biophysics, University of Toronto, Ontario, Canada
Nature 397:315-23. 1999..ligand (OPGL; also known as TRANCE, RANKL and ODF) has been identified as a potential osteoclast differentiation factor and regulator of interactions between T cells and dendritic cells in vitro...
- Evidence for a role of a tumor necrosis factor-alpha (TNF-alpha)-converting enzyme-like protease in shedding of TRANCE, a TNF family member involved in osteoclastogenesis and dendritic cell survivalL Lum
Tri Institutional Cornell Rockefeller University Memorial Sloan Kettering Cancer Center, Training Program, New York, New York 10021, USA
J Biol Chem 274:13613-8. 1999Tumor necrosis factor (TNF)-related activation-induced cytokine (TRANCE), a member of the TNF family, is a dendritic cell survival factor and is essential for osteoclastogenesis and osteoclast activation...
- Localization of RANKL (receptor activator of NF kappa B ligand) mRNA and protein in skeletal and extraskeletal tissuesV Kartsogiannis
Department of Medicine, The University of Melbourne and St Vincent s Institute of Medical Research, St Vincent s Hospital, Fitzroy, Victoria, Australia
Bone 25:525-34. 1999b>RANKL (receptor activator of NFkappaB ligand) is a membrane-associated osteoblastic molecule, and along with macrophage-colony-stimulating factor, is crucial for osteoclast formation...
- Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligandY Y Kong
Amgen Institute, Toronto, Ontario, Canada
Nature 402:304-9. 1999..remodelling and bone loss are controlled by a balance between the tumour necrosis factor family molecule osteoprotegerin ligand (OPGL) and its decoy receptor osteoprotegerin (OPG)...
- Diverse roles of the tumor necrosis factor family member TRANCE in skeletal physiology revealed by TRANCE deficiency and partial rescue by a lymphocyte-expressed TRANCE transgeneN Kim
Laboratory of Immunology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
Proc Natl Acad Sci U S A 97:10905-10. 2000Tumor necrosis factor-related, activation-induced cytokine (TRANCE), a tumor necrosis factor family member, mediates survival of dendritic cells in the immune system and is required for osteoclast differentiation and activation in the ..
- The osteoclast differentiation factor osteoprotegerin-ligand is essential for mammary gland developmentJ E Fata
Department of Medical Biophysics, Ontario Cancer Institute, University of Toronto, Canada
Cell 103:41-50. 2000Osteoprotegerin-ligand (OPGL) is a key osteoclast differentiation/activation factor essential for bone remodeling...
- T-cell-mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-gammaH Takayanagi
Department of Immunology, Faculty of Medicine and Graduate School of Medicine, University of Tokyo, Japan
Nature 408:600-5. 2000Bone resorption is regulated by the immune system, where T-cell expression of RANKL (receptor activator of nuclear factor (NF)-kappaB ligand), a member of the tumour-necrosis factor family that is essential for osteoclastogenesis, may ..
- Determination of three isoforms of the receptor activator of nuclear factor-kappaB ligand and their differential expression in bone and thymusT Ikeda
Department of Pathology and Immunology, Aging and Developmental Science, Graduate School, Tokyo Medical and Dental University, Bunkyo ku, Tokyo 113 8519, Japan
Endocrinology 142:1419-26. 2001..also known as tumor necrosis factor-related activation-induced cytokine, osteoprotegerin ligand, and osteoclast differentiation factor] is known to bind with the receptor activator of NF-kappaB (RANK) and act not only as a key factor ..
- TRANCE/RANKL knockout mice are protected from bone erosion in a serum transfer model of arthritisA R Pettit
Beth Israel Deaconess Medical Center, New England Baptist Bone and Joint Institute, Harvard Institutes of Medicine, Boston, Massachusetts 02115, USA
Am J Pathol 159:1689-99. 2001..factor-related activation-induced cytokine, also known as receptor activator of nuclear factor-kappaB ligand (TRANCE/RANKL) is an essential factor for osteoclast differentiation...
- Activation of extracellular signal-regulated kinase is involved in mechanical strain inhibition of RANKL expression in bone stromal cellsJanet Rubin
Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA
J Bone Miner Res 17:1452-60. 2002..In vitro, application of strain inhibits osteoclast formation by decreasing expression of the ligand RANKL in bone stromal cells, but the mechanism responsible for this down-regulation is unknown...
- Cyclic adenosine monophosphate/protein kinase A mediates parathyroid hormone/parathyroid hormone-related protein receptor regulation of osteoclastogenesis and expression of RANKL and osteoprotegerin mRNAs by marrow stromal cellsHisatomo Kondo
Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
J Bone Miner Res 17:1667-79. 2002..of osteoclast formation and activation, effects that are associated with reciprocal up- and down-regulation of RANKL and osteoprotegerin (OPG), respectively...
- TRAF5 functions in both RANKL- and TNFalpha-induced osteoclastogenesisKiyoshi Kanazawa
Department of Life Science, Tokyo Institute of Technology, Yokohama, Japan
J Bone Miner Res 18:443-50. 2003Although TRAF6 is essential for both RANKL- and TNFalpha-induced osteoclastogenesis, it has remained unclear whether other members of the TRAF family are involved in osteoclastogenesis...
- Mechanical strain differentially regulates endothelial nitric-oxide synthase and receptor activator of nuclear kappa B ligand expression via ERK1/2 MAPKJanet Rubin
Department of Medicine, Veterans Affairs Medical Center and Emory University School of Medicine, Atlanta, Georgia 30033, USA
J Biol Chem 278:34018-25. 2003..nitric-oxide synthase (eNOS), prevents resorption, whereas receptor activator of nuclear kappa B ligand (RANKL) promotes resorption through regulating osteoclast activity...
- PTH differentially regulates expression of RANKL and OPGJohn C Huang
Department of Growth and Development, Division of Orthodontics, University of California San Francisco School of Dentistry, San Francisco, California, USA
J Bone Miner Res 19:235-44. 2004b>RANKL and OPG gene expressions were measured with and without PTH at different stages of osteoblast development...
- TNF-related apoptosis-inducing ligand (TRAIL) blocks osteoclastic differentiation induced by RANKL plus M-CSFGiorgio Zauli
Department of Normal Human Morphology, University of Trieste, Italy
Blood 104:2044-50. 2004The role of the tumor necrosis factor (TNF) superfamily member receptor activator of nuclear factor kappa B ligand (RANKL) in promoting the differentiation of osteoclasts has been extensively characterized...
- Regulation of vascular calcification by osteoclast regulatory factors RANKL and osteoprotegerinPatricia Collin-Osdoby
Department of Biology and Division of Bone and Mineral Research, Washington University, St Louis, MO 63130, USA
Circ Res 95:1046-57. 2004..One emerging area in vascular biology involves the RANKL/RANK/OPG system, molecules of the tumor necrosis factor-related family recently discovered to be critical ..
- IL-1 mediates TNF-induced osteoclastogenesisShi Wei
Department of Pathology, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Clin Invest 115:282-90. 2005TNF-induced receptor activator NF-kappaB ligand (RANKL) synthesis by bone marrow stromal cells is a fundamental component of inflammatory osteolysis...
- Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiationDonald A Glass
Department of Molecular and Human Genetics, Bone Disease Program of Texas, Houston, 77030, USA
Dev Cell 8:751-64. 2005....
- MMP-7 promotes prostate cancer-induced osteolysis via the solubilization of RANKLConor C Lynch
Department of Cancer Biology, Vanderbilt University, Nashville, Tennessee 37232, USA
Cancer Cell 7:485-96. 2005..MMP-7, which was produced by osteoclasts at the tumor-bone interface, was capable of processing RANKL to a soluble form that promoted osteoclast activation...
- Osteoclast differentiation independent of the TRANCE-RANK-TRAF6 axisNacksung Kim
Medical Research Center for Gene Regulation, Chonnam National University Medical School, Gwangju, Korea
J Exp Med 202:589-95. 2005..factors, including the tumor necrosis factor (TNF) family member TNF-related activation-induced cytokine (TRANCE)...
- Mechanical inhibition of RANKL expression is regulated by H-Ras-GTPaseJanet Rubin
Department of Medicine, Emory University School of Medicine and Veterans Affairs Medical Center, Atlanta, Georgia 30033, USA
J Biol Chem 281:1412-8. 2006..We here investigate proximal events leading to the ERK1/2 activation that is required for mechanical repression of RANKL (receptor activator of NF-kappaB ligand) expression, the factor that controls local recruitment of osteoclasts...
- Wnt signalling in osteoblasts regulates expression of the receptor activator of NFkappaB ligand and inhibits osteoclastogenesis in vitroGary J Spencer
Biomedical Tissue Research, Department of Biology, University of York, PO Box 373, York, YO10 5YW, UK
J Cell Sci 119:1283-96. 2006..repression of the gene encoding the osteoclastogenic cytokine receptor activator of NFkappaB ligand (RANKL or TNFSF11) expressed by osteoblasts...
- Regulation of cancer cell migration and bone metastasis by RANKLD Holstead Jones
IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Dr Bohr Gasse 3, A 1030 Vienna, Austria
Nature 440:692-6. 2006..Here we show that the cytokine RANKL (receptor activator of NF-kappaB ligand) triggers migration of human epithelial cancer cells and melanoma cells ..
- A TNF receptor loop peptide mimic blocks RANK ligand-induced signaling, bone resorption, and bone lossKazuhiro Aoki
Department of Cell Biology, Yale University School of Medicine, New Haven, Connecticut 06520 8044, USA
J Clin Invest 116:1525-34. 2006..a peptide (WP9QY) that mimics this TNFR contact site and inhibits TNF-alpha-induced activity bound to RANK ligand (RANKL)...
- Amelioration of bone loss in collagen-induced arthritis by neutralizing anti-RANKL monoclonal antibodySeiji Kamijo
Department of Immunology, Juntendo University School of Medicine, Bunkyo ku, Tokyo, Japan
Biochem Biophys Res Commun 347:124-32. 2006Receptor activator of NF-kappaB (RANK) and its ligand (RANKL) are pivotal regulators of osteoclast differentiation. RANK and RANKL also mediate T cell/dendritic cell (DC) interaction...
- Receptor activator of NF-kappa B ligand and osteoprotegerin regulate proinflammatory cytokine production in miceKenta Maruyama
Department of Microbiology and Immunology, School of Medicine, Keio University, Tokyo, Japan
J Immunol 177:3799-805. 2006Receptor activator of NF-kappaB ligand (RANKL) is a membrane-bound or soluble cytokine essential for osteoclast differentiation, whereas the decoy receptor osteoprotegerin (OPG) masks RANKL activity...
- MafB negatively regulates RANKL-mediated osteoclast differentiationKabsun Kim
Research Institute of Medical Sciences and Medical Research Center for Gene Regulation, Chonnam National University Medical School, Hak Dong 5, Dong Ku, Gwangju 501 746, Korea
Blood 109:3253-9. 2007Receptor activator of nuclear factor kappaB ligand (RANKL) induces osteoclast formation from hematopoietic cells via regulation of various transcription factors...
- Msx2 -/- transgenic mice develop compound amelogenesis imperfecta, dentinogenesis imperfecta and periodental osteopetrosisM Aïoub
INSERM, UMR S 872, Les Cordeliers, F 75006, Paris, France
Bone 41:851-9. 2007..This study provides a detailed analysis of the phenotype resulting from the Msx2 null mutation and identifies the impact of Msx1 and Msx2 on post-natal oral bone growth...
- Murine and chicken chondrocytes regulate osteoclastogenesis by producing RANKL in response to BMP2Michihiko Usui
Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
J Bone Miner Res 23:314-25. 2008Chondrocytes express RANKL, but their role in osteoclastogenesis is not clear...
- Osteoprotegerin inhibits vascular calcification without affecting atherosclerosis in ldlr(-/-) miceSean Morony
Department of Molecular Cellular and Integrative Physiology, University of California, Los Angeles, USA
Circulation 117:411-20. 2008..However, genetic and treatment studies in mice suggest that osteoprotegerin may protect against vascular calcification...
- Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiationMatthew J Hilton
Department of Medicine, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, Missouri 63110, USA
Nat Med 14:306-14. 2008..Thus, mesenchymal progenitors may be expanded in vitro by activating the Notch pathway, whereas bone formation in vivo may be enhanced by transiently suppressing this pathway...
- The tumor necrosis factor family receptors RANK and CD40 cooperatively establish the thymic medullary microenvironment and self-toleranceTaishin Akiyama
Division of Cellular and Molecular Biology, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokane dai, Minato ku, Tokyo 108 8639, Japan
Immunity 29:423-37. 2008..These results show that developmental-stage-dependent cooperation between RANK and CD40 promotes mTEC development, thereby establishing self-tolerance...
- The cytokine RANKL produced by positively selected thymocytes fosters medullary thymic epithelial cells that express autoimmune regulatorYu Hikosaka
Division of Experimental Immunology, Institute for Genome Research, University of Tokushima, Tokushima 770 8503, Japan
Immunity 29:438-50. 2008..Here we show that the cytokine RANK ligand (RANKL) was produced by positively selected thymocytes and regulated the cellularity of mTEC by interacting with RANK and ..
- RANK-RANKL signaling pathway is critically involved in the function of CD4+CD25+ regulatory T cells in chronic colitisTeruji Totsuka
Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Tokyo
J Immunol 182:6079-87. 2009..In this study, we demonstrate that the TNF family molecule RANKL and its receptor RANK are critically involved in controlling the function of CD4(+)CD25(+) T(R) cells in the ..
- Osteoimmunology: crosstalk between the immune and bone systemsTomoki Nakashima
Department of Cell Signaling, Graduate School of Medical and Dental Science, Tokyo Medical and Dental University, Tokyo, Japan
J Clin Immunol 29:555-67. 2009..BONE DESTRUCTION WITH ARTHRITIS AS A RANKL DISEASE: In the bone destruction associated with RA, IL-17-producing helper T cells (T(H)17) play a major role by ..
- T lymphocytes amplify the anabolic activity of parathyroid hormone through Wnt10b signalingMasakazu Terauchi
Division of Endocrinology, Metabolism, and Lipids, Department of Medicine, Emory University, Atlanta, GA 30322, USA
Cell Metab 10:229-40. 2009....
- RANKL is necessary and sufficient to initiate development of antigen-sampling M cells in the intestinal epitheliumKathryn A Knoop
Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
J Immunol 183:5738-47. 2009..The TNF superfamily member receptor activator of NF-kappaB ligand (RANKL) is selectively expressed by subepithelial stromal cells in PP domes...
- Central control of fever and female body temperature by RANKL/RANKReiko Hanada
IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, 1030 Vienna, Austria
Nature 462:505-9. 2009Receptor-activator of NF-kappaB ligand (TNFSF11, also known as RANKL, OPGL, TRANCE and ODF) and its tumour necrosis factor (TNF)-family receptor RANK are essential regulators of bone remodelling, lymph node organogenesis and formation of ..
- Suppression of Wnt signaling by Dkk1 attenuates PTH-mediated stromal cell response and new bone formationJun Guo
Endocrine Unit, Massachusetts General Hospital, Boston, MA 02114, USA
Cell Metab 11:161-71. 2010..Our findings indicate that the full actions of PTH require intact Wnt signaling but that PTH can activate the Wnt pathway despite overexpression of Dkk1...
- Are osteoclasts needed for the bone anabolic response to parathyroid hormone? A study of intermittent parathyroid hormone with denosumab or alendronate in knock-in mice expressing humanized RANKLDominique D Pierroz
Service of Bone Diseases, Department of Rehabilitation and Geriatrics, Geneva University Hospital and Faculty of Medicine, 1211 Geneva 14, Switzerland
J Biol Chem 285:28164-73. 2010PTH stimulates osteoblastic cells to form new bone and to produce osteoblast-osteoclast coupling factors such as RANKL. Whether osteoclasts or their activity are needed for PTH anabolism remains uncertain...
- PKA-induced receptor activator of NF-kappaB ligand (RANKL) expression in vascular cells mediates osteoclastogenesis but not matrix calcificationWendy Tseng
Department of Physiological Science, University of California, Los Angeles, California 90095, USA
J Biol Chem 285:29925-31. 2010..osteoblast-production of osteoclast regulating cytokines, including receptor-activator of nuclear κB ligand (RANKL) and interleukins...
- RANK ligand mediates progestin-induced mammary epithelial proliferation and carcinogenesisEva Gonzalez-Suarez
Department of Hematology Oncology Research, Amgen Inc, Seattle, Washington 98119, USA
Nature 468:103-7. 2010RANK ligand (RANKL), a TNF-related molecule, is essential for osteoclast formation, function and survival through interaction with its receptor RANK...
- Involvement of soluble receptor activator of nuclear factor-κB ligand (sRANKL) in collagenase-induced murine osteoarthritis and human osteoarthritisPetya Dimitrova
Department of Immunology, Institute of Microbiology, Sofia, Bulgaria
Rheumatol Int 32:1317-25. 2012..At the late stage of CIOA, bone remodeling was related with increased BMP2 and RANKL expression in the joints, high sRANKL, and decreased number of activated neutrophils in synovium...
- Receptor activator of NF-kappaB (RANK) stimulates the proliferation of epithelial cells of the epidermo-pilosebaceous unitVincent Duheron
Centre National de la Recherche Scientifique, Laboratory of Therapeutic Immunology and Chemistry, Unité Propre de Recherche 9021, Institut de Biologie Moleculaire et Cellulaire, University of Strasbourg, 67084 Strasbourg, France
Proc Natl Acad Sci U S A 108:5342-7. 2011..Here, we show that mice deficient in RANK ligand (RANKL) are unable to initiate a new growth phase of the hair cycle and display arrested epidermal homeostasis...
- Increased bone mass in mice after single injection of anti-receptor activator of nuclear factor-kappaB ligand-neutralizing antibody: evidence for bone anabolic effect of parathyroid hormone in mice with few osteoclastsYuriko Furuya
Nagahama Institute for Biochemical Science, Nagahama Branch, Oriental Yeast Co, Limited, 50 Kano cho Nagahama, Shiga 526 0804, Japan
J Biol Chem 286:37023-31. 2011Receptor activator of nuclear factor-κB ligand (RANKL) is a pivotal osteoclast differentiation factor. To investigate the effect of RANKL inhibition in normal mice, we prepared an anti-mouse RANKL-neutralizing monoclonal antibody (Mab, ..
- Matrix-embedded cells control osteoclast formationJinhu Xiong
Center for Osteoporosis and Metabolic Bone Diseases, University of Arkansas for Medical Sciences UAMS, Little Rock, Arkansas, USA
Nat Med 17:1235-41. 2011..The cytokine receptor activator of nuclear factor-κB ligand (RANKL) is essential for osteoclast formation and thought to be supplied by osteoblasts or their precursors, thereby ..
- Evidence for osteocyte regulation of bone homeostasis through RANKL expressionTomoki Nakashima
Department of Cell Signaling, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Yushima, Bunkyo ku, Tokyo, Japan
Nat Med 17:1231-4. 2011..here that purified osteocytes express a much higher amount of receptor activator of nuclear factor-κB ligand (RANKL) and have a greater capacity to support osteoclastogenesis in vitro than osteoblasts and bone marrow stromal cells...
- RANKL induces organized lymph node growth by stromal cell proliferationEstelle Hess
Centre National de la Recherche Scientifique, Laboratoire d Immunopathologie et Chimie Thérapeutique, Unité Propre de Recherche 9021, Institut de Biologie Moleculaire et Cellulaire, Universite de Strasbourg, 67084 Strasbourg, France
J Immunol 188:1245-54. 2012RANK and its ligand RANKL play important roles in the development and regulation of the immune system. We show that mice transgenic for Rank in hair follicles display massive postnatal growth of skin-draining lymph nodes...
- Enhanced mineralization potential of vascular cells from SM22α-Rankl (tg) miceS Morony
Department of Metabolic Disorders, Amgen, Thousands Oaks, CA, USA
Calcif Tissue Int 91:379-86. 2012..To investigate the effect of receptor activator of NF-kB ligand (RANKL) on vascular calcification in vivo, transgenic mice, where RANKL expression was targeted to vascular smooth muscle ..
- SLAT negatively regulates RANKL-induced osteoclast differentiationBang Ung Youn
Department of Pharmacology, Medical Research Center for Gene Regulation, Chonnam National University Medical School, Gwangju, 501 746, Korea
Mol Cells 36:252-7. 2013b>RANKL induces the formation of osteoclasts, which are responsible for bone resorption. Herein, we investigated the role of SWAP-70-like adapter of T cells (SLAT) in RANKL-induced osteoclastogenesis...
- TRANCE is necessary and sufficient for osteoblast-mediated activation of bone resorption in osteoclastsK Fuller
St George s Hospital Medical School, London, United Kingdom
J Exp Med 188:997-1001. 1998b>TRANCE (tumor necrosis factor-related activation-induced cytokine) is a recently described member of the tumor necrosis factor superfamily that stimulates dendritic cell survival and has also been found to induce osteoclastic ..
- Osteoprotegerin regulates bone formation through a coupling mechanism with bone resorptionMidori Nakamura
Department of Pediatric Dentistry, Institute for Oral Science, Matsumoto Dental University, Nagano 399 0781, Japan
Endocrinology 144:5441-9. 2003..of osteoprotegerin (OPG), a soluble decoy receptor for receptor activator of nuclear factor-kappaB ligand (RANKL), in mice induces osteoporosis caused by enhanced bone resorption, but also accelerates bone formation...
- RelA/p65 promotes osteoclast differentiation by blocking a RANKL-induced apoptotic JNK pathway in miceSergio Vaira
Division of Bone and Mineral Diseases, Department of Medicine, Washington University School of Medicine, St Louis, Missouri, USA
J Clin Invest 118:2088-97. 2008..JNK-mediated apoptosis during a critical period of commitment to the OC phenotype in response to the cytokine RANKL. This RelA/p65-mediated arrest of cell death led to enhanced OC differentiation...
- Regulation of peripheral lymph node genesis by the tumor necrosis factor family member TRANCED Kim
Laboratory of Immunology, The Rockefeller University, New York, New York 10021, USA
J Exp Med 192:1467-78. 2000Proper lymph node (LN) development requires tumor necrosis factor-related activation-induced cytokine (TRANCE) expression...
- Potential role of cbfa1, an essential transcriptional factor for osteoblast differentiation, in osteoclastogenesis: regulation of mRNA expression of osteoclast differentiation factor (ODF)Y H Gao
Department of Oral Pathology, Department of Biochemistry, School of Dentistry, Showa University, 1 5 8 Hatanodai, Shinagawa ku, Tokyo, 142 8555, Japan
Biochem Biophys Res Commun 252:697-702. 1998..The expression of osteoclast differentiation factor/osteoprotegerin ligand (ODF/OPGL) mRNA was increased by the treatment with 1alpha, 25(OH)2D3 and ..
- RANKL stimulates proliferation, adhesion and IL-7 expression of thymic epithelial cellsHee Woo Lee
Department of Anatomy, School of Medicine, Pusan National University, Busan 602 739, Korea
Exp Mol Med 40:59-70. 2008..This study clearly shows that receptor activator of NF-kappaB ligand (RANKL) stimulates mouse thymic epithelial cell activities including cell proliferation, thymocyte adhesion to thymic ..
- ER Stress Mediates TiAl6V4 Particle-Induced Peri-Implant Osteolysis by Promoting RANKL Expression in FibroblastsZhenheng Wang
Jinling Hospital, Department of Orthopaedics, School of Medicine and State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, 210093, Nanjing, China
PLoS ONE 10:e0137774. 2015..To address whether ER stress was involved in the expression of RANKL, the effects of ER stress blockers (including 4-PBA and TUDCA) on the expression of RANKL in TiPs-treated ..
- The RANKL distal control region is required for the increase in RANKL expression, but not the bone loss, associated with hyperparathyroidism or lactation in adult miceMelda Onal
Center for Osteoporosis and Metabolic Bone Diseases, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
Mol Endocrinol 26:341-8. 2012..The cytokine receptor activator of nuclear factor κB ligand (RANKL) is one of a number of factors that controls the production, survival, and activity of osteoclasts...
- Spleen serves as a reservoir of osteoclast precursors through vitamin D-induced IL-34 expression in osteopetrotic op/op miceYuko Nakamichi
Division of Hard Tissue Research, Institute for Oral Science, School of Dentistry, Matsumoto Dental University, Nagano 399 0781, Japan
Proc Natl Acad Sci U S A 109:10006-11. 2012..precursors in response to colony-stimulating factor 1 (CSF-1) and receptor activator of nuclear factor-κB ligand (RANKL)...
- Receptor activator of NF-kappaB and podocytes: towards a function of a novel receptor-ligand pair in the survival response of podocyte injuryShuangxin Liu
Department of Nephrology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, China
PLoS ONE 7:e41331. 2012..The ligand of receptor activator of NF-kappaB (RANKL) and receptor activator of NF-kappaB (RANK) are members of the TNF and receptor superfamilies...
- Defective Fas ligand expression and activation-induced cell death in the absence of IL-2-inducible T cell kinaseAndrew T Miller
Department of Pathology, Program in Immunology and Virology, University of Massachusetts Medical Center, 55 Lake Avenue North, Worcester, MA 01655, USA
J Immunol 168:2163-72. 2002..Together these studies define an important role for Itk in TCR signaling, leading to cytokine gene expression and activation-induced cell death...
- Regulation of mucosal dendritic cell function by receptor activator of NF-kappa B (RANK)/RANK ligand interactions: impact on tolerance inductionEilidh Williamson
Department of Inflammation, Immunex Corp, Seattle WA 98101, USA
J Immunol 169:3606-12. 2002..expression and function of the TNFR family member receptor activator of NF-kappaB (RANK) and its cognate ligand, RANKL, in vitro and in vivo...
- Overexpression of RANKL implicates IFN-beta-mediated elimination of B-cell precursors in the osteopetrotic bone of microphthalmic miceK Roundy
Division of Cell Biology and Immunology, Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah 84132, USA
J Bone Miner Res 18:278-88. 2003..Surprisingly, the expression of a subset of such genes including RANKL, stromal-derived factor (SDF-1), B-cell lymphotactin chemokine (BLC), and RANK was dramatically enhanced in the mi ..
- IL-17 promotes bone erosion in murine collagen-induced arthritis through loss of the receptor activator of NF-kappa B ligand/osteoprotegerin balanceErik Lubberts
Rheumatology and Advanced Therapeutics, University Medical Center Nijmegen, Nijmegen, The Netherlands
J Immunol 170:2655-62. 2003..joint of type II collagen-immunized mice on bone erosion and synovial receptor activator of NF-kappa B ligand (RANKL)/receptor activator of NF-kappa B/osteoprotegerin (OPG) expression...
- Involvement of upstream stimulatory factors 1 and 2 in RANKL-induced transcription of tartrate-resistant acid phosphatase gene during osteoclast differentiationYi Liu
Department of Pathology, The University of Alabama, Birmingham, Alabama 35294, USA
J Biol Chem 278:20603-11. 2003..TRAP expression in osteoclasts is regulated by receptor activator of NF-kappaB (RANKL), a potent activator of osteoclast differentiation...
- The role of RANKL (TRANCE/TNFSF11), a tumor necrosis factor family member, in skeletal development: effects of gene knockout and transgenic rescuePaul R Odgren
Department of Cell Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
Connect Tissue Res 44:264-71. 2003We report the skeletal manifestations of restoring RANKL (TNFSF11/TRANCE; see foot note on nomenclature) expression in null mice using a lymphocyte-specific promoter...
- Streptococcus pyogenes infection induces septic arthritis with increased production of the receptor activator of the NF-kappaB ligandAtsuo Sakurai
Department of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, 1 8 Yamadaoka, Suita Osaka 565 0871, Japan
Infect Immun 71:6019-26. 2003..We noted that an increase in the amount of receptor activator of NF-kappaB ligand (RANKL), which is a key cytokine in osteoclastogenesis, was also evident in the joints of the infected mice...
- Opg, Rank, and Rankl in tooth development: co-ordination of odontogenesis and osteogenesisA Ohazama
Department of Craniofacial Development, Floor 28, Guy s Tower, GKT Dental Institute, King s College London, Guy s Hospital, London Bridge, London SE1 9RT, UK
J Dent Res 83:241-4. 2004Osteoprotegerin (OPG), receptor activator of nuclear factor-kappaB (RANK), and RANK ligand (RANKL) are mediators of various cellular interactions, including bone metabolism...
- YY1 is involved in RANKL-induced transcription of the tartrate-resistant acid phosphatase gene in osteoclast differentiationZhenqi Shi
Department of Pathology, University of Alabama at Birmingham, 1670 University Blvd, VH G046B, Birmingham, AL 35294, USA
Gene 343:117-26. 2004Receptor activator of nuclear factor kappa B (NF-kappaB) ligand (RANKL), a critical activator of osteoclast differentiation, plays a pivotal role in tartrate-resistant acid phosphatase (TRAP) gene expression...
- Monokine induced by interferon-gamma is induced by receptor activator of nuclear factor kappa B ligand and is involved in osteoclast adhesion and migrationHan Bok Kwak
National Research Laboratory for Bone Metabolism, College of Dentistry, Chosun University, Gwangju, Korea
Blood 105:2963-9. 2005..The osteoclast differentiation process requires receptor activator of nuclear factor kappa B (NF-kappa B) ligand (RANKL), which causes complex changes in the expression of various genes...
- RANK-mediated amplification of TRAF6 signaling leads to NFATc1 induction during osteoclastogenesisJin Gohda
Division of Cellular and Molecular Biology, Department of Cancer Biology, The Institute of Medical Science, The University of Tokyo, Shirokane dai, Minato ku, Tokyo, Japan
EMBO J 24:790-9. 2005..These results suggest that RANK may harbor a specific domain that amplifies TRAF6 signaling...
- The molecular scaffold Gab2 is a crucial component of RANK signaling and osteoclastogenesisTeiji Wada
Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Dr Bohrgasse 3 5, A 1030 Vienna, Austria
Nat Med 11:394-9. 2005..Receptor activator of NF-kappaB (RANK) and its ligand RANKL have been identified as essential factors involved in osteoclast development and bone remodeling, but their ..
- Synovial fibroblasts promote osteoclast formation by RANKL in a novel model of spontaneous erosive arthritisYalei Wu
University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
Arthritis Rheum 52:3257-68. 2005..This study was undertaken to explore the roles of hyperproliferating synovial fibroblasts and macrophages in abnormal osteoclast formation, using the recently described BXD2 mouse model of RA...
- Receptor activator of NF-kappaB ligand regulates the proliferation of mammary epithelial cells via Id2Nam Shik Kim
Division of Molecular and Life Sciences, Pohang University of Science and Technology, Pohang 790 783, Kyungbuk, South Korea
Mol Cell Biol 26:1002-13. 2006Receptor activator of NF-kappaB ligand (RANKL) is a key regulator for mammary gland development during pregnancy. RANKL-deficient mice display impaired development of lobulo-alveolar mammary structures...
- Epidermal RANKL controls regulatory T-cell numbers via activation of dendritic cellsKarin Loser
Department of Dermatology, University of Munster, D 48149 Munster, Germany
Nat Med 12:1372-9. 2006..Receptor activator of NF-kappaB (RANK) and its ligand (RANKL; also known as CD254, OPGL and TRANCE) are key regulators of bone remodeling, mammary gland formation, lymph node development and T-cell/dendritic cell ..
- Macrophage inflammatory protein-1alpha (MIP-1alpha) enhances a receptor activator of nuclear factor kappaB ligand (RANKL) expression in mouse bone marrow stromal cells and osteoblasts through MAPK and PI3K/Akt pathwaysMasanobu Tsubaki
Division of Pharmacotherapy, Kinki University School of Pharmacy, 3 4 1, Kowakae, Higashi Osaka, Osaka 577 8502, Japan
Mol Cell Biochem 304:53-60. 2007..In the present study, our group investigated the mechanism by which RANKL expression is induced by MIP-1alpha and the effects of MIP-1alpha on the activation of osteoclasts...
- Host-derived RANKL is responsible for osteolysis in a C4-2 human prostate cancer xenograft model of experimental bone metastasesColm Morrissey
Department of Urology, University of Washington, Seattle, WA, USA
BMC Cancer 7:148. 2007..Administration of osteoprotegerin (OPG) blocks these increases, indicating the critical role of RANKL in osteolysis in this model...
- RANKL-induced down-regulation of CX3CR1 via PI3K/Akt signaling pathway suppresses Fractalkine/CX3CL1-induced cellular responses in RAW264.7 cellsYurika Saitoh
Division of Pathogenic Biochemistry, Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
Biochem Biophys Res Commun 364:417-22. 2007The receptor activator of nuclear factor-kappaB ligand (RANKL) is essential for osteoclast differentiation. In this study, we examined the effects of RANKL on chemokine receptor expression in osteoclast precursor cells, RAW264.7 cells...
- Osteoporotic bone formation in mice lacking tob2; involvement of Tob2 in RANK ligand expression and osteoclasts differentiationRieko Ajima
The Institute of Medical Science, University of Tokyo, 4 6 1, Shirokanedai, Minato ku, Tokyo 108 8639, Japan
FEBS Lett 582:1313-8. 2008..Furthermore, expression of RANKL mRNA in stromal cells was increased in the absence of Tob2 and decreased in the presence of Tob2...
- The role of nitric oxide in the mechanical repression of RANKL in bone stromal cellsJill Rahnert
Applied Physiology, Georgia Institute of Technology College of Sciences, Atlanta GA 30332, USA
Bone 43:48-54. 2008..At the same time, strain causes decreased expression of RANKL, a factor critical for osteoclastogenesis...
- Epidermal receptor activator of NF-kappaB ligand controls Langerhans cells numbers and proliferationJean Baptiste O Barbaroux
St John s Institute of Dermatology, King s College London, London, United Kingdom
J Immunol 181:1103-8. 2008..The TNF superfamily member receptor activator of NF-kappaB ligand (RANKL, TNFSF11) has been shown to sustain viability of blood dendritic cells in addition to its role in promoting proliferation ..
- Influence of simultaneous targeting of the bone morphogenetic protein pathway and RANK/RANKL axis in osteolytic prostate cancer lesion in boneMandeep S Virk
Department of Orthopaedic Surgery, The New England Musculoskeletal Institute, University of Connecticut Health Center, Farmington, CT 06030 5456, USA
Bone 44:160-7. 2009..In this study, we investigated the effect of simultaneous blockade of BMP pathway and RANK/RANKL axis in an osteolytic prostate cancer lesion in bone...
- Interaction between angiotensin II, osteoprotegerin, and peroxisome proliferator-activated receptor-gamma in abdominal aortic aneurysmCorey S Moran
Vascular Biology Unit, School of Medicine, James Cook University, Townsville, Queensland, Australia
J Vasc Res 46:209-17. 2009..The ability of peroxisome proliferator-activated receptor-gamma (PPARgamma) activation to target OPG as potential therapy for AAA was also investigated...
- Down-regulation of mTOR leads to up-regulation of osteoprotegerin in bone marrow cellsMakio Mogi
Department of Medicinal Biochemistry, School of Pharmacy, Aichi Gakuin University, Nagoya, Aichi, Japan
Biochem Biophys Res Commun 384:82-6. 2009..Thus, suitable suppression of mTOR phosphorylation is a necessary requirement for OPG production in bone marrow stromal cells...
- Oxidized low density lipoprotein decreases Rankl-induced differentiation of osteoclasts by inhibition of Rankl signalingCécile Mazière
INSERM ERI 12, Amiens, France
J Cell Physiol 221:572-8. 2009..In the current studies, the effect of Cu(2+)-oxidized LDL (OxLDL) on RANKL-induced RAW264...
- Extracellular signal-regulated kinase 1 (ERK1) and ERK2 play essential roles in osteoblast differentiation and in supporting osteoclastogenesisTakehiko Matsushita
Department of Orthopaedics, Case Western Reserve University, 2109 Adelbert Road, BRB 329, Cleveland, OH 44106, USA
Mol Cell Biol 29:5843-57. 2009..Furthermore, inactivation of ERK1 and ERK2 significantly reduced RANKL expression, accounting for a delay in osteoclast formation...
- NF-kappaB p100 limits TNF-induced bone resorption in mice by a TRAF3-dependent mechanismZhenqiang Yao
Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, 601 Elmwood Ave, Rochester, NY 14642, USA
J Clin Invest 119:3024-34. 2009TNF and RANKL mediate bone destruction in common bone diseases, including osteoarthritis and RA. They activate NF-kappaB canonical signaling directly in osteoclast precursors (OCPs) to induce osteoclast formation in vitro...
- Osteoprotegerin expression and sensitivity in otosclerosis with different histological activityTamás Karosi
Department of Otolaryngology and Head and Neck Surgery, Medical and Health Science Center, University of Debrecen, Nagyerdei krt 98, Debrecen 4032, Hungary
Eur Arch Otorhinolaryngol 268:357-65. 2011..As to previous and current results, decreased OPG sensitivity of lesion-forming cells should be excluded. These observations may indicate the potential role of recombinant OPG treatment in early stages of otosclerosis...
- Lymphotoxin signal promotes thymic organogenesis by eliciting RANK expression in the embryonic thymic stromaYasuhiro Mouri
Division of Molecular Immunology, Institute for Enzyme Research, The University of Tokushima, Tokushima 770 8503, Japan
J Immunol 186:5047-57. 2011..Thus, the LTβR signal exhibits a novel and unique function in promoting RANK activity for mTEC organization, indicating a link between thymic organogenesis mediated by multiple cytokine signals and the control of autoimmunity...
- Prominent bone loss mediated by RANKL and IL-17 produced by CD4+ T cells in TallyHo/JngJ miceHee Yeon Won
Division of Life and Pharmaceutical Sciences, College of Pharmacy, Center for Cell Signaling and Drug Discovery Research, Ewha Womans University, Seoul, Korea
PLoS ONE 6:e18168. 2011..and osteoprotegerin were decreased in TH mice, whereas osteoclast-driven bone resorption markers such as IL-6 and RANKL were significantly elevated in the bone marrow and blood of TH mice...
- The mouse RANKL gene locus is defined by a broad pattern of histone H4 acetylation and regulated through distinct distal enhancersMelissa L Martowicz
Department of Biochemistry, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
J Cell Biochem 112:2030-45. 2011b>RANKL is a stromal cell-derived tumor necrosis factor (TNF)-like factor that plays a primary role in osteoclast formation and function...
- The expression of osteoprotegerin is required for maintaining the intervertebral disc endplate of aged miceQian Qian Liang
Department of Orthopaedics and Traumatology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, PR China
Bone 48:1362-9. 2011..Here we assessed the phenotype change of IVD in OPG(-/-) mice...
- Osteoclasts are dispensable for hematopoietic stem cell maintenance and mobilizationKana Miyamoto
Department of Orthopedic Surgery, Keio Kanrinmaru Project, Keio University School of Medicine, Shinjuku ku, Tokyo, Japan
J Exp Med 208:2175-81. 2011..activity in three osteopetrotic mouse models: op/op, c-Fos-deficient, and RANKL (receptor activator of nuclear factor kappa B ligand)-deficient mice...
- Osteoprotegerin reverses osteoporosis by inhibiting endosteal osteoclasts and prevents vascular calcification by blocking a process resembling osteoclastogenesisH Min
Department of Biosystems Analysis, Amgen, Incorporated, Thousand Oaks, California 91320, USA
J Exp Med 192:463-74. 2000..Although OPG is normally expressed in arteries, OPG ligand (OPGL) and receptor activator of NF-kappaB (RANK) are not detected in the arterial walls of wild-type adult mice...
- Crystal structure of the extracellular domain of mouse RANK ligand at 2.2-A resolutionShuichiro Ito
Biomedical Research Laboratories, Sankyo, CO, Ltd 1 2 58, Hiromachi, Shinagawa ku, Tokyo, 140 8710, Japan
J Biol Chem 277:6631-6. 2002..Receptor activator of NF-kappa B ligand (RANKL, also known as ODF and OPGL), a member of the tumor necrosis factor (TNF) family, triggers osteoclastogenesis by ..
- Epigenetic control of mouse receptor activator of NF-kappa B ligand gene expressionSohei Kitazawa
Division of Molecular Pathology, Department of Biomedical Informatics, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
Biochem Biophys Res Commun 293:126-31. 2002Receptor activator of NF-kappa B ligand (RANKL) is a membrane-bound signal transducer requisite for differentiation and maintenance of osteoclasts...
- IN VIVO REGULATION OF IL6 AND IL6R GENE EXPRESSIONCHARLES O BRIEN; Fiscal Year: 2002..Finally, cis-acting regulatory elements in the IL-6 promoter that are the targets for estrogen and PTH actions in vivo will be identified. ..
- TRANCE REGULATION OF CHONDROCYTE MATURATIONPAUL ODGREN; Fiscal Year: 2005..Adapted from the Investigator's Abstract): This project will investigate the hypothesis that the growth factor TRANCE directly regulates both cartilage maturation and bone growth in the appendicular and craniofacial skeleton using ..
- SACRAL CREST CELLS AND ENTERIC NEURODEVELOPMENTRaj Kapur; Fiscal Year: 2005..The results of this study will further our understanding of normal enteric neurodevelopment and congenital disorders of intestinal motility. ..
- Combinatorial Protein Transfer for Cancer TherapeuticsAoshuang Chen; Fiscal Year: 2006..abstract_text> ..