Tnfrsf4

Summary

Gene Symbol: Tnfrsf4
Description: tumor necrosis factor receptor superfamily, member 4
Alias: ACT35, CD134, Ly-70, Ox40, TXGP1L, Txgp1, tumor necrosis factor receptor superfamily member 4, OX40 antigen, OX40L receptor, tax-transcriptionally activated glycoprotein 1
Species: mouse

Top Publications

  1. ncbi Critical role of OX40 in CD28 and CD154-independent rejection
    Gulcin Demirci
    Department of Medicine, Harvard Medical School, and Division of Immunology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Immunol 172:1691-8. 2004
  2. pmc OX40 costimulation turns off Foxp3+ Tregs
    Minh Diem Vu
    Harvard Medical School, Transplant Research Center, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Blood 110:2501-10. 2007
  3. ncbi Cutting edge: OX40 inhibits TGF-beta- and antigen-driven conversion of naive CD4 T cells into CD25+Foxp3+ T cells
    Takanori So
    Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    J Immunol 179:1427-30. 2007
  4. ncbi OX40 controls functionally different T cell subsets and their resistance to depletion therapy
    Alexander Kroemer
    Harvard Medical School, Transplant Research Center, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
    J Immunol 179:5584-91. 2007
  5. doi Phosphoinositide 3-kinase activity in T cells regulates the magnitude of the germinal center reaction
    Julia Rolf
    Laboratory of Lymphocyte Signalling and Development, Babraham Institute, Cambridge, United Kingdom
    J Immunol 185:4042-52. 2010
  6. pmc Autocrine transforming growth factor-β1 promotes in vivo Th17 cell differentiation
    Ilona Gutcher
    Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Immunity 34:396-408. 2011
  7. pmc Pathogenic roles of CD14, galectin-3, and OX40 during experimental cerebral malaria in mice
    Miranda S Oakley
    Division of Bacterial, Parasitic and Allergenic Products, Center for Biologics and Evaluation Research, Food and Drug Administration, Bethesda, MD, USA
    PLoS ONE 4:e6793. 2009
  8. ncbi Cross-linking of OX40 ligand, a member of the TNF/NGF cytokine family, induces proliferation and differentiation in murine splenic B cells
    E Stuber
    Mucosal Immunity Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Immunity 2:507-21. 1995
  9. pmc Molecular characterization of murine and human OX40/OX40 ligand systems: identification of a human OX40 ligand as the HTLV-1-regulated protein gp34
    P R Baum
    Department of Gene Expression, Immunex R and D Corporation, Seattle, WA 98101
    EMBO J 13:3992-4001. 1994
  10. ncbi OX40 is differentially expressed on activated rat and mouse T cells and is the sole receptor for the OX40 ligand
    A Al-Shamkhani
    MRC Cellular Immunology Unit, University of Oxford, GB
    Eur J Immunol 26:1695-9. 1996

Research Grants

  1. Cornea Epithelial Stem Cell Isolation for Bioengineering
    De Quan Li; Fiscal Year: 2005
  2. T Cell Memory to Respiratory Viral Infections
    Shahram Salek Ardakani; Fiscal Year: 2008

Scientific Experts

  • Yan Jinchuan
  • De-Quan Li
  • William L Redmond
  • B R Blazar
  • M Kopf
  • Zili Zhang
  • Phillip J Sanchez
  • David R Withers
  • Vasileios Bekiaris
  • Shahram Salek-Ardakani
  • Robert H Arch
  • Florian Obermeier
  • M Moser
  • Michael Croft
  • Takanori So
  • Jianxun Song
  • Andrew D Weinberg
  • Nigel Killeen
  • Silvia Piconese
  • Naoto Ishii
  • Xiang Xiao
  • Shahram Salek Ardakani
  • Kazuo Sugamura
  • Carl E Ruby
  • Mario P Colombo
  • Mi Yeon Kim
  • Anthony T Vella
  • Robert S Mittler
  • Pejman Soroosh
  • Alexander Kroemer
  • Gulcin Demirci
  • Xian Chang Li
  • Aihua Song
  • Dalya R Soond
  • Julia Rolf
  • Harry Z Qui
  • Ian R Humphreys
  • Fabrina M C Gaspal
  • Joong Kyu Kim
  • Claudio Tripodo
  • Mark Klinger
  • Suman Bandyopadhyay
  • Wei Duan
  • Giorgia Gri
  • Wenda Gao
  • Minh Diem Vu
  • Barbara Valzasina
  • Xiaohong Tang
  • Li Rung Huang
  • Fengyang Lei
  • Bernardo Sgarbi Reis
  • Cortny A Huddleston
  • Hideo Yagita
  • Taylor H Schreiber
  • Tobias Boettler
  • Fiona M McConnell
  • Chandra Raykundalia
  • Peter J L Lane
  • Ryoko Hamano
  • Liang Jie Xu
  • Nicole A Vasilevsky
  • Pratima Bansal-Pakala
  • Klaus Okkenhaug
  • Joao G Magalhaes
  • Ilona Gutcher
  • Martin Turner
  • D Keith Bishop
  • Xian C Li
  • Jun Qi Yang
  • Triya Damayanti
  • Adam J Adler
  • Andrea Gorzanelli
  • Adam T Hagymasi
  • David J Erle
  • Bryna E Burrell
  • Julien Diana
  • Kazuko Murata
  • Tobias Polte
  • Miranda S Oakley
  • Rute Marques
  • Daniel Hirschhorn-Cymerman
  • Barbara Frossi
  • Carlo E Pucillo
  • Amnon Altman
  • Michael J Gough
  • Fabrina Gaspal
  • Seyed Fazlollah Mousavi
  • Jun Abe
  • Seung Joo Lee
  • Hector L Aguila

Detail Information

Publications104 found, 100 shown here

  1. ncbi Critical role of OX40 in CD28 and CD154-independent rejection
    Gulcin Demirci
    Department of Medicine, Harvard Medical School, and Division of Immunology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Immunol 172:1691-8. 2004
    ..DKO) mice) and used this model to examine the role of novel costimulatory molecule-inducible costimulator (ICOS), OX40, 4-1BB, and CD27 in mediating CD28/CD154-independent rejection...
  2. pmc OX40 costimulation turns off Foxp3+ Tregs
    Minh Diem Vu
    Harvard Medical School, Transplant Research Center, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Blood 110:2501-10. 2007
    b>OX40 is a recently identified T-cell costimulatory molecule that belongs to the TNF/TNFR superfamily. OX40 can be expressed by both activated T effector cells and Foxp3(+) Tregs...
  3. ncbi Cutting edge: OX40 inhibits TGF-beta- and antigen-driven conversion of naive CD4 T cells into CD25+Foxp3+ T cells
    Takanori So
    Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    J Immunol 179:1427-30. 2007
    ..Here we show that OX40 (CD134) signaling inhibits TGF-beta-driven Foxp3 mRNA and suppresses the conversion of naive Ag-specific transgenic CD4 T ..
  4. ncbi OX40 controls functionally different T cell subsets and their resistance to depletion therapy
    Alexander Kroemer
    Harvard Medical School, Transplant Research Center, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
    J Immunol 179:5584-91. 2007
    ..anti-lymphocyte serum (ALS) mediated depletion exhibit phenotypic features of memory cells and uniformly express OX40 on the cell surface...
  5. doi Phosphoinositide 3-kinase activity in T cells regulates the magnitude of the germinal center reaction
    Julia Rolf
    Laboratory of Lymphocyte Signalling and Development, Babraham Institute, Cambridge, United Kingdom
    J Immunol 185:4042-52. 2010
    ..Our findings support a model in which the magnitude of the GC reaction is controlled by the activity of the PI3K pathway in T(FH) cells...
  6. pmc Autocrine transforming growth factor-β1 promotes in vivo Th17 cell differentiation
    Ilona Gutcher
    Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Immunity 34:396-408. 2011
    ..These findings reveal an essential role for activated T cell-produced TGF-β1 in promoting the differentiation of Th17 cells and controlling inflammatory diseases...
  7. pmc Pathogenic roles of CD14, galectin-3, and OX40 during experimental cerebral malaria in mice
    Miranda S Oakley
    Division of Bacterial, Parasitic and Allergenic Products, Center for Biologics and Evaluation Research, Food and Drug Administration, Bethesda, MD, USA
    PLoS ONE 4:e6793. 2009
    ..genes to the pathogenesis of ECM, we examined the biological relevance of three molecules -- CD14, galectin-3, and OX40 that were previously shown to be overexpressed during ECM...
  8. ncbi Cross-linking of OX40 ligand, a member of the TNF/NGF cytokine family, induces proliferation and differentiation in murine splenic B cells
    E Stuber
    Mucosal Immunity Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Immunity 2:507-21. 1995
    b>OX40 is a member of the TNF/NGF-receptor family expressed on activated T cells, whose ligand is found on activated T and B cells...
  9. pmc Molecular characterization of murine and human OX40/OX40 ligand systems: identification of a human OX40 ligand as the HTLV-1-regulated protein gp34
    P R Baum
    Department of Gene Expression, Immunex R and D Corporation, Seattle, WA 98101
    EMBO J 13:3992-4001. 1994
    A ligand was cloned for murine OX40, a member of the TNF receptor family, using a T cell lymphoma cDNA library...
  10. ncbi OX40 is differentially expressed on activated rat and mouse T cells and is the sole receptor for the OX40 ligand
    A Al-Shamkhani
    MRC Cellular Immunology Unit, University of Oxford, GB
    Eur J Immunol 26:1695-9. 1996
    b>OX40, a member of the tumor necrosis factor (TNF) receptor/nerve growth factor (NGF) receptor superfamily was first identified as a marker of activated rat CD4+ cells with the MRC OX40 monoclonal antibody (mAb)...
  11. ncbi Robust B cell immunity but impaired T cell proliferation in the absence of CD134 (OX40)
    S D Pippig
    Department of Microbiology and Immunology, University of California, San Francisco 94143, USA
    J Immunol 163:6520-9. 1999
    b>CD134 (OX40) is a member of the TNF receptor family that is expressed on activated T lymphocytes...
  12. ncbi The OX40 costimulatory receptor determines the development of CD4 memory by regulating primary clonal expansion
    I Gramaglia
    Division of Immunochemistry, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    J Immunol 165:3043-50. 2000
    The costimulatory receptor OX40 has recently been shown to be involved in primary CD4 responses to several defined Ags...
  13. pmc Development of allergic inflammation in a murine model of asthma is dependent on the costimulatory receptor OX40
    A G Jember
    Division of Immunochemistry, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    J Exp Med 193:387-92. 2001
    ..In this report, we have investigated the role of the tumor necrosis factor receptor family member OX40 in allergic inflammation using OX40-deficient mice...
  14. ncbi OX40 promotes Bcl-xL and Bcl-2 expression and is essential for long-term survival of CD4 T cells
    P R Rogers
    Division of Immunochemistry, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    Immunity 15:445-55. 2001
    It is important to understand which molecules are essential for long-lived immunity. We show that OX40 (CD134) is required with CD28 for the survival of CD4 T cells following antigen-driven expansion...
  15. ncbi Engagement of OX40 enhances antigen-specific CD4(+) T cell mobilization/memory development and humoral immunity: comparison of alphaOX-40 with alphaCTLA-4
    D E Evans
    Earle A Chiles Research Institute, Robert W Franz Cancer Research Center, Providence Portland Medical Center, Portland, OR 97213, USA
    J Immunol 167:6804-11. 2001
    ..Previously, we reported that OX40 engagement resulted in a 60-fold increase in the number of Ag-specific CD4(+) memory T cells that persisted 60 days ..
  16. ncbi Constitutive OX40/OX40 ligand interaction induces autoimmune-like diseases
    Kazuko Murata
    Department of Microbiology and Immunology, Tohoku University Graduate School of Medicine, 2 1 Seiryo machi, Aobu ku, Sendai 980 8575, Japan
    J Immunol 169:4628-36. 2002
    The interaction between OX40 and OX40 ligand (OX40L) is suggested to provide T cells with an effective costimulatory signals during T cell-APC interaction...
  17. ncbi Expression and costimulatory effects of the TNF receptor superfamily members CD134 (OX40) and CD137 (4-1BB), and their role in the generation of anti-tumor immune responses
    Vadim Y Taraban
    Tenovus Research Laboratory, Cancer Sciences Division, The School of Medicine, University of Southampton, Southampton, GB
    Eur J Immunol 32:3617-27. 2002
    This study addresses the relative importance of CD134 (OX40) and CD137 (4-1BB) in the costimulation of CD4+ and CD8+ T cells under comparable conditions of antigenic stimulation...
  18. ncbi CD4(+)CD3(-) accessory cells costimulate primed CD4 T cells through OX40 and CD30 at sites where T cells collaborate with B cells
    Mi Yeon Kim
    Medical Research Council Centre for Immune Regulation, University of Birmingham Medical School, United Kingdom
    Immunity 18:643-54. 2003
    ..cells, the CD4(+)CD3(-) cells have little CD80 or CD86 expression but do express high levels of the TNF ligands, OX40 ligand and CD30 ligand...
  19. ncbi Expression of CD30 and Ox40 on T lymphocyte subsets is controlled by distinct regulatory mechanisms
    Holly M Toennies
    Department of Medicine, Washington University, School of Medicine, St Louis, MO 63110, USA
    J Leukoc Biol 75:350-7. 2004
    ..Although some TNFR-related molecules are constitutively expressed, others, such as CD30 and Ox40, are induced upon activation of lymphocytes...
  20. ncbi The costimulation-regulated duration of PKB activation controls T cell longevity
    Jianxun Song
    Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    Nat Immunol 5:150-8. 2004
    ..Here we show that in the absence of OX40 costimulation, antigen-activated CD4+ cells are short-lived because the activity of protein kinase B (PKB; also ..
  21. ncbi Distinct roles for the OX40-OX40 ligand interaction in regulatory and nonregulatory T cells
    Ikuo Takeda
    Department of Microbiology and Immunology, Tohoku University Graduate School of Medicine, Sendai, Japan
    J Immunol 172:3580-9. 2004
    The OX40 (CD134) molecule is induced primarily during T cell activation and, as we show in this study, is also expressed on CD25+CD4+ regulatory T (Treg) cells...
  22. ncbi Costimulation of CD8 T cell responses by OX40
    Pratima Bansal-Pakala
    Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    J Immunol 172:4821-5. 2004
    ..Using OX40-deficient CD8 cells specific for a defined Ag, and agonist and antagonist OX40 reagents, we show that OX40/OX40 ..
  23. ncbi A signal through OX40 (CD134) allows anergic, autoreactive T cells to acquire effector cell functions
    Stephanie K Lathrop
    Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, OR 97239, USA
    J Immunol 172:6735-43. 2004
    ..Provision of a costimulatory signal by coinjection of an agonist Ab to OX40 (CD134), a TNFR family member expressed on activated CD4 T cells, results in death of the mice within 12 days...
  24. ncbi Triggering of OX40 (CD134) on CD4(+)CD25+ T cells blocks their inhibitory activity: a novel regulatory role for OX40 and its comparison with GITR
    Barbara Valzasina
    Immunotherapy and Gene Therapy Unit, Department of Experimental Oncology, Istituto Nazionale per lo Studio e la Cura dei Tumori, Via Venezian 1, 20133 Milan, Italy
    Blood 105:2845-51. 2005
    OX40 (CD134) is a member of the tumor necrosis factor (TNF) receptor family that is transiently expressed on T cells after T-cell receptor (TCR) ligation...
  25. ncbi OX40 signals during priming on dendritic cells inhibit CD4 T cell proliferation: IL-4 switches off OX40 signals enabling rapid proliferation of Th2 effectors
    Mi Yeon Kim
    Medical Research Council Centre for Immune Regulation, Birmingham Medical School, Birmingham, United Kingdom
    J Immunol 174:1433-7. 2005
    In this study we examined the role and regulation of OX40 signals during CD4 T cell priming on dendritic cells (DCs)...
  26. ncbi Vaccination with dendritic cells pulsed with apoptotic tumors in combination with anti-OX40 and anti-4-1BB monoclonal antibodies induces T cell-mediated protective immunity in Her-2/neu transgenic mice
    Camilo Cuadros
    Sidney Kimmel Cancer Center, San Diego, CA 92121, USA
    Int J Cancer 116:934-43. 2005
    ..Administration of multiple immunizations in combination with the costimulatory agonist anti-OX40 or anti-4-1BB MAb significantly enhanced the immune responses in these mice, resulting in complete tumor rejection ..
  27. ncbi Sustained survivin expression from OX40 costimulatory signals drives T cell clonal expansion
    Jianxun Song
    Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    Immunity 22:621-31. 2005
    ..Here, we show that Survivin is controlled in peripheral T cells by OX40 cosignaling via sustained PI3k and PKB activation...
  28. ncbi During viral infection of the respiratory tract, CD27, 4-1BB, and OX40 collectively determine formation of CD8+ memory T cells and their capacity for secondary expansion
    Jenny Hendriks
    Division of Immunology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
    J Immunol 175:1665-76. 2005
    Independent studies have shown that CD27, 4-1BB, and OX40 can all promote survival of activated CD8+ T cells...
  29. ncbi OX40 and Bcl-xL promote the persistence of CD8 T cells to recall tumor-associated antigen
    Aihua Song
    Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    J Immunol 175:3534-41. 2005
    ..response to tumor-expressed Ag following adoptive T cell transfer, we show that CD8 effector cells deficient in OX40, a TNFR family member, could not mediate short-term tumor suppression. OX40 was required at two critical stages...
  30. ncbi OX40 costimulation synergizes with GM-CSF whole-cell vaccination to overcome established CD8+ T cell tolerance to an endogenous tumor antigen
    Satoshi Murata
    Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    J Immunol 176:974-83. 2006
    T cell costimulation via OX40 is known to increase CD4+ T cell expansion and effector function and enhances the development of T cell memory. OX40 costimulation can also prevent, and even reverse, CD4+ T cell anergy...
  31. ncbi OX40 (CD134) engagement drives differentiation of CD4+ T cells to effector cells
    Cortny A Huddleston
    Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, OR 97239, USA
    Eur J Immunol 36:1093-103. 2006
    ..Addition of an agonist antibody to OX40 (CD134), a costimulatory TNF receptor family member expressed on activated CD4+ T cells, enables the proliferating T ..
  32. ncbi OX40-OX40 ligand interaction through T cell-T cell contact contributes to CD4 T cell longevity
    Pejman Soroosh
    Department of Microbiology and Immunology, Tohoku University Graduate School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    J Immunol 176:5975-87. 2006
    Signals through the OX40 costimulatory receptor on naive CD4 T cells are essential for full-fledged CD4 T cell activation and the generation of CD4 memory T cells...
  33. ncbi Interruption of the Tnfrsf4/Tnfsf4 (OX40/OX40L) pathway attenuates atherogenesis in low-density lipoprotein receptor-deficient mice
    Eva J A van Wanrooij
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Gorlaeus Laboratories, Leiden University, P O Box 9502, 2300 RA Leiden, The Netherlands
    Arterioscler Thromb Vasc Biol 27:204-10. 2007
    ..b>Tnfrsf4 (OX40) and Tnfsf4 (OX40 ligand) are members of the tumor necrosis factor (TNF) and TNF receptor family and OX40/..
  34. ncbi Cooperation between CD4 and CD8 T cells for anti-tumor activity is enhanced by OX40 signals
    Aihua Song
    Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92037, USA
    Eur J Immunol 37:1224-32. 2007
    The relative contribution of OX40 (CD134) to priming of CD8 T cells in complex systems where CD4 and CD8 cells respond and cooperate together is not clear...
  35. ncbi OX40 costimulation promotes persistence of cytomegalovirus-specific CD8 T Cells: A CD4-dependent mechanism
    Ian R Humphreys
    Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    J Immunol 179:2195-202. 2007
    ..The basis for this shift in CD8 T populations is unknown. In this study, we demonstrate that OX40, a TNFR superfamily member, specifically regulates the accumulation of CD8 T cells reactive with the persistent-..
  36. ncbi CD134 Costimulation Couples the CD137 Pathway to Induce Production of Supereffector CD8 T Cells That Become IL-7 Dependent
    Seung Joo Lee
    Department of Immunology, University of Connecticut Health Center, Farmington, CT 06030, USA
    J Immunol 179:2203-14. 2007
    The TNFR superfamily members 4-1BB (CD137) and OX40 (CD134) are costimulatory molecules that potently boost CD8 and CD4 T cell responses...
  37. pmc Nitric oxide induces CD4+CD25+ Foxp3 regulatory T cells from CD4+CD25 T cells via p53, IL-2, and OX40
    Wanda Niedbala
    Division of Immunology, Infection, and Inflammation, Glasgow Biomedical Research Centre, 120 University Place, University of Glasgow, Glasgow G12 8TA, United Kingdom
    Proc Natl Acad Sci U S A 104:15478-83. 2007
    ..The induction of Tregs (NO-Tregs) is independent of cGMP but depends on p53, IL-2, and OX40. NO-Tregs produced IL-4 and IL-10, but not IL-2, IFNgamma, or TGFbeta...
  38. ncbi Defects in the acquisition of CD8 T cell effector function after priming with tumor or soluble antigen can be overcome by the addition of an OX40 agonist
    William L Redmond
    Earle A Chiles Research Institute, Robert W Franz Cancer Research Center, Providence Portland Medical Center, Portland, OR 97213, USA
    J Immunol 179:7244-53. 2007
    Several members of the TNFR superfamily, including OX40 (CD134), 4-1BB (CD137), and CD27 provide critical costimulatory signals that promote T cell survival and differentiation in vivo...
  39. ncbi Critical synergy of CD30 and OX40 signals in CD4 T cell homeostasis and Th1 immunity to Salmonella
    Fabrina Gaspal
    Medical Research Council Centre for Immune Regulation, Division of Immunity and Infection, University of Birmingham, Birmingham, United Kingdom
    J Immunol 180:2824-9. 2008
    CD30 and OX40 (CD134) are members of the TNFR superfamily expressed on activated CD4 T cells, and mice deficient in both these molecules harbor a striking defect in the capacity to mount CD4 T cell-dependent memory Ab responses...
  40. pmc OX40 triggering blocks suppression by regulatory T cells and facilitates tumor rejection
    Silvia Piconese
    Immunotherapy and Gene Therapy Unit, Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milan, Italy
    J Exp Med 205:825-39. 2008
    ..We show that T reg cells can be functionally inactivated by OX40 triggering. In tumors, the vast majority of CD4(+) T cells are Foxp3(+) and OX40(bright)...
  41. pmc Activation of NF-kappaB1 by OX40 contributes to antigen-driven T cell expansion and survival
    Jianxun Song
    Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    J Immunol 180:7240-8. 2008
    The costimulatory molecule OX40 (CD134) is required in many instances for effective T cell-mediated immunity, controlling proliferation, and survival of T cells after encountering specific Ag...
  42. doi OX40 agonist therapy enhances CD8 infiltration and decreases immune suppression in the tumor
    Michael J Gough
    Robert W Franz Cancer Center, Earle A Chiles Research Institute, Providence Portland Medical Center, Portland, Oregon 97213, USA
    Cancer Res 68:5206-15. 2008
    ..requires appropriate costimulatory signals, including ligation of the costimulatory molecule OX40 (TNFRSF4, CD134)...
  43. ncbi OX40/OX40L costimulation affects induction of Foxp3+ regulatory T cells in part by expanding memory T cells in vivo
    Xiang Xiao
    Harvard Medical School, Transplant Research Center, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
    J Immunol 181:3193-201. 2008
    b>OX40 is a member of the TNFR superfamily and has potent T cell costimulatory activities...
  44. pmc OX40 costimulatory signals potentiate the memory commitment of effector CD8+ T cells
    Seyed Fazlollah Mousavi
    Department of Microbiology and Immunology, Tohoku University Graduate School of Medicine, Sendai, Japan
    J Immunol 181:5990-6001. 2008
    A T cell costimulatory molecule, OX40, contributes to T cell expansion, survival, and cytokine production...
  45. pmc Self-antigen prevents CD8 T cell effector differentiation by CD134 and CD137 dual costimulation
    Suman Bandyopadhyay
    Department of Immunology, University of Connecticut Health Center, Farmington, CT 06030 1601, USA
    J Immunol 181:7728-37. 2008
    ..Enforced dual costimulation through OX40 and 4-1BB redirected CD8 cells encountering soluble exogenous peptide to expand and differentiate into IFN-gamma ..
  46. pmc OX40 drives protective vaccinia virus-specific CD8 T cells
    Shahram Salek-Ardakani
    Division of Molecular Immunology, La JollaInstitute for Allergy and Immunology, San Diego, CA 92037, USA
    J Immunol 181:7969-76. 2008
    ..We show that the TNFR molecule OX40 (CD134) controls primary VACV-specific CD8 T cell expansion and antiviral cytokine production and dictates development of ..
  47. pmc Thymic OX40 expression discriminates cells undergoing strong responses to selection ligands
    Mark Klinger
    Department of Microbiology and Immunology and
    J Immunol 182:4581-9. 2009
    b>OX40 is a member of the TNF receptor family expressed on activated and regulatory T (Treg) cells...
  48. pmc OX40 engagement and chemotherapy combination provides potent antitumor immunity with concomitant regulatory T cell apoptosis
    Daniel Hirschhorn-Cymerman
    Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    J Exp Med 206:1103-16. 2009
    ..use of the alkylating agent cyclophosphamide (CTX) and an agonist antibody targeting the co-stimulatory receptor OX40 (OX86) provides potent antitumor immunity capable of regressing established, poorly immunogenic B16 melanoma tumors...
  49. doi Synergistic OX40 and CD30 signals sustain CD8+ T cells during antigenic challenge
    Vasileios Bekiaris
    Medical Research Council Centre for Immune Regulation, Birmingham Medical School, University of Birmingham, Birmingham, UK
    Eur J Immunol 39:2120-5. 2009
    ..Utilizing two different antigenic stimuli, we provide evidence that the tumor necrosis factor receptors OX40 and CD30 integrate synergistic signals during the expansion phase to help maintain CD8(+) effectors...
  50. pmc Impact of the TCR signal on regulatory T cell homeostasis, function, and trafficking
    Joong Kyu Kim
    Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA, USA
    PLoS ONE 4:e6580. 2009
    ..The significance of TCR signaling in regulatory T (Treg) cells has not been systematically addressed. Using an Ox40-cre allele that is prominently expressed in Treg cells, and a conditional null allele of the gene encoding p56(Lck),..
  51. pmc Ligation of the OX40 co-stimulatory receptor reverses self-Ag and tumor-induced CD8 T-cell anergy in vivo
    William L Redmond
    Earle A Chiles Research Institute, Robert W Franz Cancer Research Center, Providence Portland Medical Center, Portland, OR 97213, USA
    Eur J Immunol 39:2184-94. 2009
    ..Recent work has demonstrated that signaling through the OX40 (CD134) co-stimulatory receptor, a member of the TNFR super-family, can augment CD4 and CD8 T-cell expansion, ..
  52. pmc The survival of memory CD4+ T cells within the gut lamina propria requires OX40 and CD30 signals
    David R Withers
    Medical Research Council Centre for Immune Regulation, Institute for Biomedical Research, Medical School, University of Birmingham, Birmingham, United Kingdom
    J Immunol 183:5079-84. 2009
    ..In this study, we demonstrate that, in the absence of signals through both OX40 and CD30, CD4(+) T cells are comprehensively depleted from the lamina propria...
  53. pmc Generalized immune activation as a direct result of activated CD4+ T cell killing
    Rute Marques
    Division of Immunoregulation, MRC National Institute for Medical Research, The Ridgeway, London NW7 1AA, UK
    J Biol 8:93. 2009
    ..In addition to progressive CD4(+) T cell immune deficiency, HIV infection is characterized by generalized immune activation, thought to arise from increased microbial exposure resulting from diminishing immunity...
  54. doi A non-redundant role for OX40 in the competitive fitness of Treg in response to IL-2
    Silvia Piconese
    Molecular Immunology Unit, Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
    Eur J Immunol 40:2902-13. 2010
    b>OX40 stimulation is known to enhance activation of effector T cells and to inhibit induction and suppressive function of Treg...
  55. pmc NBR1 is a new PB1 signalling adapter in Th2 differentiation and allergic airway inflammation in vivo
    Jun Qi Yang
    Department of Cancer and Cell Biology, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    EMBO J 29:3421-33. 2010
    ..These results establish NBR1 as a novel PB1 adapter in Th2 differentiation and asthma...
  56. pmc The TNFR family members OX40 and CD27 link viral virulence to protective T cell vaccines in mice
    Shahram Salek-Ardakani
    Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, California 92037, USA
    J Clin Invest 121:296-307. 2011
    ..With strongly replicating (i.e., virulent) VACV, the TNFR family costimulatory receptors OX40 (also known as CD134) and CD27 were engaged and promoted the generation of high numbers of memory CD8+ T cells, which protected against ..
  57. pmc Antigen-independent signalosome of CARMA1, PKCθ, and TNF receptor-associated factor 2 (TRAF2) determines NF-κB signaling in T cells
    Takanori So
    Divisions of Molecular Immunology and Cell Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 108:2903-8. 2011
    ..We now show that one TNFR family member, OX40 (CD134), after ligation by OX40L, assembles a unique complex that not only contains TRAF2, RIP, and IKKα/β/γ but also ..
  58. pmc OX40 complexes with phosphoinositide 3-kinase and protein kinase B (PKB) to augment TCR-dependent PKB signaling
    Takanori So
    Division of Immune Regulation, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    J Immunol 186:3547-55. 2011
    ..in activated or effector T cells are important, and these can be strongly influenced by signaling from OX40 (CD134), a member of the TNFR superfamily...
  59. pmc CD134 plus CD137 dual costimulation induces Eomesodermin in CD4 T cells to program cytotoxic Th1 differentiation
    Harry Z Qui
    Department of Immunology, University of Connecticut Health Center, Farmington, CT 06030, USA
    J Immunol 187:3555-64. 2011
    ..We demonstrate that CD134 (OX40) costimulation programs naive self- and virus-reactive CD4 T cells to undergo in vivo differentiation into ..
  60. ncbi [Effect of the costimulatory molecules OX40-OX40 ligand interaction on the expression of NFATc1 in leukocytes of apolipoprotein E-deficient mice]
    Liang Jie Xu
    Department of Cardiology, Affiliated Hospital of Jiangsu University, Zhenjiang 212001, China
    Zhonghua Xin Xue Guan Bing Za Zhi 39:526-30. 2011
    To investigate the effect of OX40/OX40L interaction on the nuclear factor of activated T cells c1 (NFATc1) in ApoE-/- mice.
  61. pmc New insights on OX40 in the control of T cell immunity and immune tolerance in vivo
    Xiang Xiao
    Transplant Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Immunol 188:892-901. 2012
    b>OX40 is a T cell costimulatory molecule that belongs to the TNFR superfamily. In the absence of immune activation, OX40 is selectively expressed by Foxp3(+) regulatory T cells (Tregs), but not by resting conventional T cells...
  62. pmc An alternative signal 3: CD8⁺ T cell memory independent of IL-12 and type I IFN is dependent on CD27/OX40 signaling
    Phillip J Sanchez
    Integrated Department of Immunology, University of Colorado Denver, National Jewish Health, CO 80206, United States
    Vaccine 30:1154-61. 2012
    ..In contrast, antigen specific CD8(+) T cell responses are compromised in the absence of the TNF receptors CD27 and OX40. These data indicate that CD27/OX40 can serve the central function as signal 3 mediators, independent of IFN or IL-..
  63. pmc OX40 facilitates control of a persistent virus infection
    Tobias Boettler
    Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, California, United States of America
    PLoS Pathog 8:e1002913. 2012
    ..Here, we show that the co-stimulatory molecule OX40 (CD134) is critically required in the context of persistent LCMV clone 13 infection...
  64. ncbi OX40-deficient mice are defective in Th cell proliferation but are competent in generating B cell and CTL Responses after virus infection
    M Kopf
    Basel Institute for Immunology, Basel, Switzerland
    Immunity 11:699-708. 1999
    b>OX40, a member of the TNF receptor superfamily, is expressed on activated T cells and implicated in stimulation of T cells and T-dependent humoral responses...
  65. ncbi CD134 plays a crucial role in the pathogenesis of EAE and is upregulated in the CNS of patients with multiple sclerosis
    Susanna Carboni
    Serono Pharmaceutical Research Institute, 14, Chemin Aulx, 1228 Plan les Ouates, Switzerland
    J Neuroimmunol 145:1-11. 2003
    We investigated the role of the CD134 (also named OX40) molecule in experimental allergic encephalomyelitis (EAE) and multiple sclerosis (MS)...
  66. ncbi Mice deficient in OX40 and CD30 signals lack memory antibody responses because of deficient CD4 T cell memory
    Fabrina M C Gaspal
    Medical Research Council Center for Immune Regulation, Institute for Biomedical Research, Birmingham Medical School, Birmingham, United Kingdom
    J Immunol 174:3891-6. 2005
    Recently, we reported that a CD4(+)CD3(-)CD11c(-) accessory cell provided OX40-dependent survival signals to follicular T cells...
  67. ncbi Cloning of mouse Ox40: a T cell activation marker that may mediate T-B cell interactions
    D M Calderhead
    Bristol Myers Squibb Pharmaceutical Research Institute, Department of Molecular Immunology, Seattle, WA 98121
    J Immunol 151:5261-71. 1993
    A cDNA library was prepared from the murine Th cell line Th2 D.10 and used to clone the murine homologue of Ox40 by polymerase chain reaction...
  68. pmc Pten loss in CD4 T cells enhances their helper function but does not lead to autoimmunity or lymphoma
    Dalya R Soond
    Laboratory of Lymphocyte Signalling and Development, Babraham Institute, Cambridge CB22 3AT, United Kingdom
    J Immunol 188:5935-43. 2012
    ..We induced conditional deletion of Pten from CD4 Th cells using a Cre knocked into the Tnfrsf4 (OX40) locus to generate OX40(Cre)Pten(f) mice...
  69. pmc T cell costimulation by TNFR superfamily (TNFRSF)4 and TNFRSF25 in the context of vaccination
    Taylor H Schreiber
    Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL 33101, USA
    J Immunol 189:3311-8. 2012
    ..To determine the relative functionality of TNFRSF4 and TNFRSF25 in T cell immunity, the activity of TNFRSF4 and TNFRS25 agonistic Abs was compared in the context of ..
  70. pmc Mutual expression of the transcription factors Runx3 and ThPOK regulates intestinal CD4⁺ T cell immunity
    Bernardo Sgarbi Reis
    Laboratory of Mucosal Immunology, The Rockefeller University, New York, New York, USA
    Nat Immunol 14:271-80. 2013
    ..Our results demonstrate considerable plasticity in the CD4(+) T cell lineage that allows chronic exposure to luminal antigens without pathological inflammation...
  71. doi Intrahepatic myeloid-cell aggregates enable local proliferation of CD8(+) T cells and successful immunotherapy against chronic viral liver infection
    Li Rung Huang
    Institutes of Molecular Medicine and Experimental Immunology, University of Bonn, Bonn, Germany
    Nat Immunol 14:574-83. 2013
    ..via tumor-necrosis factor (TNF) caused iMATE formation that facilitated costimulation dependent on the receptor OX40 for expansion of the CTL population...
  72. pmc Transgenic expression of survivin compensates for OX40-deficiency in driving Th2 development and allergic inflammation
    Fengyang Lei
    Department of Microbiology and Immunology, The Pennsylvania State University College of Medicine, Hershey, PA, USA
    Eur J Immunol 43:1914-24. 2013
    ..and that constitutive expression of survivin reversed the defective lung inflammation even in the absence of OX40 costimulation...
  73. pmc 4-1BB and Ox40 are members of a tumor necrosis factor (TNF)-nerve growth factor receptor subfamily that bind TNF receptor-associated factors and activate nuclear factor kappaB
    R H Arch
    Department of Medicine, Howard Hughes Medical Institute, The University of Chicago, Illinois 60637, USA
    Mol Cell Biol 18:558-65. 1998
    ..4-1BB and Ox40 are two recently described members of this protein family which are expressed primarily on activated T cells...
  74. pmc T cell accumulation in B cell follicles is regulated by dendritic cells and is independent of B cell activation
    Simon Fillatreau
    Institute of Cell, Animal and Population Biology, University of Edinburgh, Ashworth Laboratories, King s Buildings, West Mains Road, Edinburgh EH9 3JT, Scotland, UK
    J Exp Med 197:195-206. 2003
    ..Crucially, the up-regulation of OX40L (on antigen-presenting cells) and CXCR-5 (on T cells) are CD40-dependent events and we show that T cells do not migrate to follicles in immunized OX40-deficient mice.
  75. ncbi Cutting edge: CD28 controls peripheral homeostasis of CD4+CD25+ regulatory T cells
    Qizhi Tang
    University of California San Francisco Diabetes Center, University of California, San Francisco, CA 94143, USA
    J Immunol 171:3348-52. 2003
    ..CD28 maintains a stable pool of peripheral Tregs by both supporting their survival and promoting their self-renewal. CD28 engagement promotes survival by regulating IL-2 production by conventional T cells and CD25 expression on Tregs...
  76. ncbi OX40/OX40L interaction induces the expression of CXCR5 and contributes to chronic colitis induced by dextran sulfate sodium in mice
    Florian Obermeier
    Department of Internal Medicine I, University of Regensburg, Regensburg, Germany
    Eur J Immunol 33:3265-74. 2003
    ..To test whether OX40/OX40L interaction plays a role in chronic intestinal inflammation, we induced chronic colitis using dextran sulfate ..
  77. ncbi CCR5-deficient mice control Mycobacterium tuberculosis infection despite increased pulmonary lymphocytic infiltration
    Holly M Scott Algood
    Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    J Immunol 173:3287-96. 2004
    ..Bacterial numbers in the lymph nodes were also higher in CCR5(-/-) mice. Therefore, CCR5 may play a role in the migration of dendritic cells to and from the lymph nodes during M. tuberculosis infection...
  78. ncbi Prevention of diabetes in NOD mice at a late stage by targeting OX40/OX40 ligand interactions
    Syamasundar V Pakala
    Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    Eur J Immunol 34:3039-46. 2004
    ..Hence, it is possible that other ligand/receptor pairs control a later phase of disease. We now show that OX40 is expressed on CD4 and CD8 T cells several weeks prior to islet destruction, which is initiated around weeks 12-14,..
  79. ncbi OX40 (CD134) blockade inhibits the co-stimulatory cascade and promotes heart allograft survival
    Allison J Curry
    Department of Surgery, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom
    Transplantation 78:807-14. 2004
    b>CD134 (OX40) is a member of the tumor necrosis factor receptor superfamily that is expressed as a late event in T-cell activation and contributes to the generation of immunologic memory...
  80. pmc Where CD4+CD25+ T reg cells impinge on autoimmune diabetes
    Zhibin Chen
    Section on Immunology and Immunogenetics, Joslin Diabetes Center, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    J Exp Med 202:1387-97. 2005
    ..Thus, T reg cells primarily impinge on autoimmune diabetes by reining in destructive T cells inside the islets, more than during the initial activation in the draining lymph nodes...
  81. pmc CD4+CD25+ regulatory T cells suppress mast cell degranulation and allergic responses through OX40-OX40L interaction
    Giorgia Gri
    Department of Biomedical Science and Technology, University of Udine, 33100 Udine, Italy
    Immunity 29:771-81. 2008
    ..Treg cells directly inhibited the FcvarepsilonRI-dependent MC degranulation through cell-cell contact involving OX40-OX40L interactions between Treg cells and MCs, respectively...
  82. pmc Increased Foxp3(+) CD4(+) regulatory T cells with intact suppressive activity but altered cellular localization in murine lupus
    Jun Abe
    Department of Molecular Preventive Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Am J Pathol 173:1682-92. 2008
    ..Taken together, we conclude that T(reg) cells in BWF1 mice are not predisposed to functional incompetence but rather are present in a highly activated state...
  83. pmc Antagonism of airway tolerance by endotoxin/lipopolysaccharide through promoting OX40L and suppressing antigen-specific Foxp3+ T regulatory cells
    Wei Duan
    Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    J Immunol 181:8650-9. 2008
    ..induced OX40L expression on dendritic cells and B cells that resulted in a synergistic activity between TLR4 and OX40 signals, leading to production of IL-4, IFN-gamma, and IL-6, which blocked Treg development...
  84. pmc OX40 costimulation prevents allograft acceptance induced by CD40-CD40L blockade
    Bryna E Burrell
    Section of General Surgery, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA
    J Immunol 182:379-90. 2009
    ..Herein, we demonstrate that stimulating OX40 overrides cardiac allograft acceptance induced by disrupting CD40-CD40L interactions...
  85. ncbi OX40-enhanced tumor rejection and effector T cell differentiation decreases with age
    Carl E Ruby
    Earle A Chiles Research Institute, Providence Portland Medical Center, Portland, OR 97213, USA
    J Immunol 182:1481-9. 2009
    b>OX40 agonists have potent immunotherapeutic effects against a variety of murine tumors, yet it is unclear the role that age-related immune senescence plays on their efficacy...
  86. doi Serial OX40 engagement on CD4+ T cells and natural killer T cells causes allergic airway inflammation
    Triya Damayanti
    Department of Pulmonary Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan
    Am J Respir Crit Care Med 181:688-98. 2010
    b>OX40-OX40 ligand (OX40L) interactions have been proposed to support induction of allergic airway inflammation, which may be attributable to OX40 signaling in CD4(+) helper T cells for adaptive immune responses...
  87. pmc Activation of OX40 augments Th17 cytokine expression and antigen-specific uveitis
    Zili Zhang
    Departments of Pediatrics, Oregon Health and Science University, Portland, OR 97239, USA
    Am J Pathol 177:2912-20. 2010
    ..Activated T cells express an inducible costimulatory molecule called OX40, and OX40 in turn promotes the activation and proliferation of these lymphocytes...
  88. pmc OX40 engagement stabilizes Mxd4 and Mnt protein levels in antigen-stimulated T cells leading to an increase in cell survival
    Nicole A Vasilevsky
    Earle A Chiles Research Institute, Providence Portland Medical Center, Portland, OR 97213 2933, USA
    Eur J Immunol 41:1024-34. 2011
    b>OX40 engagement on activated T cells leads to increased proliferation, expansion and survival of Ag-specific T cells...
  89. pmc TNF optimally activatives regulatory T cells by inducing TNF receptor superfamily members TNFR2, 4-1BB and OX40
    Ryoko Hamano
    Laboratory of Molecular Immunoregulation, Cancer Inflammation Program, Center for Cancer Research, NCI Frederick, Frederick, MD 21702 1201, USA
    Eur J Immunol 41:2010-20. 2011
    ..we show that TNF, in concert with IL-2, preferentially up-regulated mRNA and surface expression of TNFR2, 4-1BB and OX40 on Tregs. Agonistic antibodies against 4-1BB and OX40 also induced the proliferation of suppressive Tregs...
  90. pmc Nucleotide oligomerization domain-containing proteins instruct T cell helper type 2 immunity through stromal activation
    Joao G Magalhaes
    Department of Immunology, University of Toronto, Toronto, ON, Canada M5A 2N4
    Proc Natl Acad Sci U S A 108:14896-901. 2011
    ..thymic stromal lymphopoietin production by the stromal cells and the up-regulation of the costimulatory molecule, OX40 ligand, on dendritic cells...
  91. ncbi The human OX40 homolog: cDNA structure, expression and chromosomal assignment of the ACT35 antigen
    U Latza
    Institute of Pathology, Free University of Berlin, FRG
    Eur J Immunol 24:677-83. 1994
    ..cell line revealed strong homology of the cDNA and its encoded protein sequence with the formerly described rat OX40 antigen. The 1...
  92. ncbi Gene structure and chromosomal localization of the mouse homologue of rat OX40 protein
    M L Birkeland
    MRC Cellular Immunology Unit, Sir William Dunn School of Pathology, University of Oxford, GB
    Eur J Immunol 25:926-30. 1995
    The OX40 protein is expressed only on activated rat CD4+ T blasts and is a member of a superfamily of cell surface molecules which includes CD40, CD30, CD95 (Fas), CD27, 4-1BB antigens and the receptors for tumor necrosis factor (TNF) and ..
  93. pmc Positional cloning of the mouse saccharin preference (Sac) locus
    A A Bachmanov
    Monell Chemical Senses Center, Philadelphia, PA 19104, USA
    Chem Senses 26:925-33. 2001
    ..This study provides compelling evidence that Tas1r3 is equivalent to the Sac locus and that the T1R3 receptor responds to sweeteners...
  94. ncbi Multiple levels of activation of murine CD8(+) intraepithelial lymphocytes defined by OX40 (CD134) expression: effects on cell-mediated cytotoxicity, IFN-gamma, and IL-10 regulation
    H C Wang
    Department of Basic Sciences, Dental Branch, University of Texas Health Science Center, Houston, TX 77030, USA
    J Immunol 167:6717-23. 2001
    The involvement of OX40 (CD134) in the activation of CD8(+) intestinal intraepithelial lymphocytes (IELs) has been studied using freshly isolated IELs and in vitro CD3-stimulated IELs...
  95. ncbi Genetic contributions of nonautoimmune SWR mice toward lupus nephritis
    S Xie
    Simmon s Arthritis Research Center and Center for Immunology, University of Texas Southwestern Medical School, Dallas, TX 75390, USA
    J Immunol 167:7141-9. 2001
    ..In conclusion, lupus in the SNF(1) strain is truly polygenic, with at least four dominant contributions from the SWR strain. The immunological functions and molecular identities of these loci await elucidation...
  96. ncbi OX40 ligation on activated T cells enhances the control of Cryptococcus neoformans and reduces pulmonary eosinophilia
    Ian R Humphreys
    Center for Molecular Microbiology and Infection, Department of Biochemistry, Imperial College of Science, Technology and Medicine, London, United Kingdom
    J Immunol 170:6125-32. 2003
    ..The immunological mechanisms that protect against eosinophilia are not fully understood. Interaction of OX40 (CD134) and its ligand, OX40L, has been implicated in T cell activation and cell migration...
  97. pmc OX40 (CD134) controls memory T helper 2 cells that drive lung inflammation
    Shahram Salek-Ardakani
    La Jolla Institute for Allergy and Immunology, Division of Immunochemistry, 10355 Science Center Dr, San Diego, CA 92121, USA
    J Exp Med 198:315-24. 2003
    ..Here we show that the costimulatory molecule OX40 is expressed on memory CD4 cells...
  98. ncbi Contribution of CD30/CD153 but not of CD27/CD70, CD134/OX40L, or CD137/4-1BBL to the optimal induction of protective immunity to Mycobacterium avium
    Manuela Flórido
    Laboratory of Microbiology and Immunology of Infection, Institute for Molecular and Cell Biology, Portugal
    J Leukoc Biol 76:1039-46. 2004
    A panel of monoclonal antibodies specific for CD27 ligand (CD70), CD30 ligand (CD153), CD134 ligand (OX40L), and CD137 ligand (4-1BBL) were screened in vivo for their ability to affect the control of Mycobacterium avium infection in ..
  99. ncbi 4-1BB and OX40 act independently to facilitate robust CD8 and CD4 recall responses
    Wojciech Dawicki
    Department of Immunology, University of Toronto, 1 King s College Circle, Toronto, Ontario, Canada
    J Immunol 173:5944-51. 2004
    Mice deficient in OX40 or 4-1BB costimulatory pathways show defects in T cell recall responses, with predominant effects on CD4 vs CD8 T cells, respectively...
  100. pmc Signals from OX40 regulate nuclear factor of activated T cells c1 and T cell helper 2 lineage commitment
    Takanori So
    Division of Molecular Immunology, La Jolla Institute for Allergy and Immunology, San Diego, CA 92121, USA
    Proc Natl Acad Sci U S A 103:3740-5. 2006
    ..Here we demonstrate that costimulation through the tumor necrosis factor receptor family molecule OX40, in synergy with CD28, is essential for high levels of nuclear factor of activated T cells c1 to accumulate in the ..
  101. ncbi IL-18 bridges innate and adaptive immunity through IFN-gamma and the CD134 pathway
    Joseph R Maxwell
    Department of Immunology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, USA
    J Immunol 177:234-45. 2006
    ..these effectors occurred, IL-18 was shown to induce OX40L on dendritic cells, whereas peptide stimulation induced CD134 (OX40) on specific T cells...

Research Grants2

  1. Cornea Epithelial Stem Cell Isolation for Bioengineering
    De Quan Li; Fiscal Year: 2005
    ..This work will have important scientific significance and high impact on the adult stem cell concept, not only for cornea and ocular surface, but also for other tissues. ..
  2. T Cell Memory to Respiratory Viral Infections
    Shahram Salek Ardakani; Fiscal Year: 2008
    ..CD8 T cell responses are highly regulated by the tumor-necrosis-factor receptor (TNFR) family member, OX40 (CD134)...