Tnfrsf1b

Summary

Gene Symbol: Tnfrsf1b
Description: tumor necrosis factor receptor superfamily, member 1b
Alias: CD120b, TNF-R-II, TNF-R2, TNF-R75, TNF-alphaR2, TNFBR, TNFR80, TNFRII, TNFalpha-R2, Tnfr-1, Tnfr2, p75, tumor necrosis factor receptor superfamily member 1B, TNF receptor beta chain, TNF-RII, TNFR-II, p75 TNFR, p80 TNF-alpha receptor, tumor necrosis factor receptor 2, tumor necrosis factor receptor type II
Species: mouse

Top Publications

  1. ncbi Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU-rich elements: implications for joint and gut-associated immunopathologies
    D Kontoyiannis
    Laboratory of Molecular Genetics, Hellenic Pasteur Institute, Athens, Greece
    Immunity 10:387-98. 1999
  2. pmc Toll-like receptors activate programmed necrosis in macrophages through a receptor-interacting kinase-3-mediated pathway
    Sudan He
    Cyrus Tang Hematology Center, Jiangsu Institute of Hematology, First Affiliated Hospital, Soochow University, Suzhou 215123, China
    Proc Natl Acad Sci U S A 108:20054-9. 2011
  3. doi Ischaemic postconditioning protects against reperfusion injury via the SAFE pathway
    Lydia Lacerda
    Hatter Cardiovascular Research Institute, Cardioprotection Group, Department of Medicine, Faculty of Health Sciences, University of Cape Town, Observatory 7925, Cape Town, South Africa
    Cardiovasc Res 84:201-8. 2009
  4. ncbi Assignment of the mouse homologues of 6 loci from HSA1p to chromosomes 3 and 4
    P J McClive
    Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Parkville, Victoria, Australia
    Genomics 23:243-6. 1994
  5. pmc Interferon-gamma receptor-mediated but not tumor necrosis factor receptor type 1- or type 2-mediated signaling is crucial for the activation of cerebral blood vessel endothelial cells and microglia in murine Toxoplasma encephalitis
    M Deckert-Schlüter
    Institut für Neuropathologie, Universitatskliniken Bonn, Bonn, Germany
    Am J Pathol 154:1549-61. 1999
  6. ncbi Cutting edge: resistance to apoptosis and continuous proliferation of dendritic cells deficient for TNF receptor-1
    J O Funk
    Department of Dermatology, University of Erlangen, Erlangen, Germany
    J Immunol 165:4792-6. 2000
  7. pmc Interleukin-1-mediated hematopoietic cell regulation in the aorta-gonad-mesonephros region of the mouse embryo
    Claudia Orelio
    Department of Cell Biology and Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands
    Blood 112:4895-904. 2008
  8. doi TNF receptor 1 and 2 contribute in different ways to resistance to Legionella pneumophila-induced mortality in mice
    Masaki Fujita
    Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Cytokine 44:298-303. 2008
  9. pmc TNF-α contributes to spinal cord synaptic plasticity and inflammatory pain: distinct role of TNF receptor subtypes 1 and 2
    Ling Zhang
    Department of Anesthesiology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Pain 152:419-27. 2011
  10. pmc Tumor necrosis factor receptor 1-dependent depletion of mucus in immature small intestine: a potential role in neonatal necrotizing enterocolitis
    Steven J McElroy
    Dept of Pediatrics, Div of Neonatology, Nashville, TN 37232 0696, USA
    Am J Physiol Gastrointest Liver Physiol 301:G656-66. 2011

Research Grants

  1. Defending Against Systemic Mycoses
    GEORGE DEEPE; Fiscal Year: 2008
  2. PROTECTIVE ANTIGENS FROM HISTOPLASMA CAPSULATUM
    GEORGE DEEPE; Fiscal Year: 2007
  3. Direct Regulation of CD8 T Cells by Interferon gamma
    Marulasiddappa Suresh; Fiscal Year: 2010
  4. Enhancement of CD8 T Cell Immunity by IL-7 Therapy
    Marulasiddappa Suresh; Fiscal Year: 2008
  5. Transport of TNFalpha across the BBB
    Weihong Pan; Fiscal Year: 2008
  6. Transport of neurotrophic cytokines after spinal cord injury
    Weihong Pan; Fiscal Year: 2007
  7. 2008 Biology of Acute Respiratory Infections Gordon Research Conference
    JOSEPH MIZGERD; Fiscal Year: 2007
  8. TUMOR NECROSIS FACTOR INVOLVEMENT IN FUMONISIN TOXICITY
    RAGHUBIR SHARMA; Fiscal Year: 2001
  9. Cell Specific Responses to TNF-alpha in Lung Fibrosis
    Gloria Pryhuber; Fiscal Year: 2009
  10. T reg Cells in Myocarditis
    Sally A Huber; Fiscal Year: 2010

Detail Information

Publications156 found, 100 shown here

  1. ncbi Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU-rich elements: implications for joint and gut-associated immunopathologies
    D Kontoyiannis
    Laboratory of Molecular Genetics, Hellenic Pasteur Institute, Athens, Greece
    Immunity 10:387-98. 1999
    ..e., chronic inflammatory arthritis and Crohn's-like inflammatory bowel disease, suggests that defective function of ARE may be etiopathogenic for the development of analogous human pathologies...
  2. pmc Toll-like receptors activate programmed necrosis in macrophages through a receptor-interacting kinase-3-mediated pathway
    Sudan He
    Cyrus Tang Hematology Center, Jiangsu Institute of Hematology, First Affiliated Hospital, Soochow University, Suzhou 215123, China
    Proc Natl Acad Sci U S A 108:20054-9. 2011
    ..Taken together, these data indicate that there are multiple upstream necrosis-initiating signaling pathways converging on the RIP3 during an innate immune response to viral and bacterial infections in mammals...
  3. doi Ischaemic postconditioning protects against reperfusion injury via the SAFE pathway
    Lydia Lacerda
    Hatter Cardiovascular Research Institute, Cardioprotection Group, Department of Medicine, Faculty of Health Sciences, University of Cape Town, Observatory 7925, Cape Town, South Africa
    Cardiovasc Res 84:201-8. 2009
    ....
  4. ncbi Assignment of the mouse homologues of 6 loci from HSA1p to chromosomes 3 and 4
    P J McClive
    Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Parkville, Victoria, Australia
    Genomics 23:243-6. 1994
    ....
  5. pmc Interferon-gamma receptor-mediated but not tumor necrosis factor receptor type 1- or type 2-mediated signaling is crucial for the activation of cerebral blood vessel endothelial cells and microglia in murine Toxoplasma encephalitis
    M Deckert-Schlüter
    Institut für Neuropathologie, Universitatskliniken Bonn, Bonn, Germany
    Am J Pathol 154:1549-61. 1999
    ..A similar response was seen in mice genetically deficient for either TNFR1, TNFR2, or both TNFRs, whereas IFN-gammaR-deficient (IFN-gammaR0/0) mice were found to be defective in the up-regulation ..
  6. ncbi Cutting edge: resistance to apoptosis and continuous proliferation of dendritic cells deficient for TNF receptor-1
    J O Funk
    Department of Dermatology, University of Erlangen, Erlangen, Germany
    J Immunol 165:4792-6. 2000
    ..In contrast, DC derived from wild-type, TNFR2(-/-), or TNFR1/2(-/-) mice survived for only 3-4 wk...
  7. pmc Interleukin-1-mediated hematopoietic cell regulation in the aorta-gonad-mesonephros region of the mouse embryo
    Claudia Orelio
    Department of Cell Biology and Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands
    Blood 112:4895-904. 2008
    ..Our results suggest that IL-1 is an important homeostatic regulator at the earliest time of HSC development, acting to limit the differentiation of some HSCs along the myeloid lineage...
  8. doi TNF receptor 1 and 2 contribute in different ways to resistance to Legionella pneumophila-induced mortality in mice
    Masaki Fujita
    Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Cytokine 44:298-303. 2008
    ..pneumophila. L. pneumophila was inoculated intranasally into TNF receptor (TNFR)-1-knock-out mice or TNFR2-knock-out mice...
  9. pmc TNF-α contributes to spinal cord synaptic plasticity and inflammatory pain: distinct role of TNF receptor subtypes 1 and 2
    Ling Zhang
    Department of Anesthesiology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Pain 152:419-27. 2011
    ..We investigated the distinct roles of TNFR1 and TNFR2 in spinal cord synaptic transmission and inflammatory pain...
  10. pmc Tumor necrosis factor receptor 1-dependent depletion of mucus in immature small intestine: a potential role in neonatal necrotizing enterocolitis
    Steven J McElroy
    Dept of Pediatrics, Div of Neonatology, Nashville, TN 37232 0696, USA
    Am J Physiol Gastrointest Liver Physiol 301:G656-66. 2011
    ..These TNF-α-induced changes in mucus mRNA levels required TNF receptor 2 (TNFR2), whereas TNF-α-induced loss of mucus-positive goblet cells required TNFR1...
  11. pmc TNF-alpha is a critical negative regulator of type 1 immune activation during intracellular bacterial infection
    Anna Zganiacz
    Infectious Diseases Division, Centre for Gene Therapeutics, and Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    J Clin Invest 113:401-13. 2004
    ..in part by suppressing T cell proliferation, and this suppression involved both TNF receptor p55 and TNF receptor p75. Heightened type 1 immune activation also occurred in TNF(-/-) mice treated with dead mycobacteria, live ..
  12. ncbi Upregulation of the p75 but not the p55 TNF-alpha receptor mRNA after silica and bleomycin exposure and protection from lung injury in double receptor knockout mice
    L A Ortiz
    Section of Pulmonary Diseases, Critical Care and Environmental Medicine, Section of Endocrinology, Tulane University Medical Center, New Orleans, Louisiana, USA
    Am J Respir Cell Mol Biol 20:825-33. 1999
    We have investigated a potential role for tumor necrosis factor (TNF)-alpha and its two receptors (p55 and p75) in lung injury. We used several varieties of mice exposed endotracheally to two fibrogenic agents, silica (0...
  13. pmc Tumor necrosis factor alpha rapidly activates the mitogen-activated protein kinase (MAPK) cascade in a MAPK kinase kinase-dependent, c-Raf-1-independent fashion in mouse macrophages
    B W Winston
    Department of Pediatrics, National Jewish Center for Immunology and Respiratory Medicine, Denver, CO 80206
    Proc Natl Acad Sci U S A 92:1614-8. 1995
    Tumor necrosis factor alpha (TNF alpha) is bound by two cell surface receptors, CD120a (p55) and CD120b (p75), that belong to the TNF/nerve growth factor receptor family and whose signaling is initiated by receptor multimerization in the ..
  14. ncbi Crucial role of tumor necrosis factor (TNF) receptor 2 and membrane-bound TNF in experimental cerebral malaria
    R Lucas
    Department of Anesthesiology, Pharmacology and Surgical Intensive Care, University Medical Center, Geneva, Switzerland
    Eur J Immunol 27:1719-25. 1997
    ..A significant increase in the expression of TNF-receptor 2 (TNFR2, p75), but not of TNFR1 (p55), was found on brain microvessels at the time of CM in susceptible animals...
  15. pmc Absence of tumor necrosis factor rescues RelA-deficient mice from embryonic lethality
    T S Doi
    Laboratory of Immunology, Aichi Cancer Center Research Institute, Nagoya 464, Japan
    Proc Natl Acad Sci U S A 96:2994-9. 1999
    ..Thus, the RelA-mediated antiapoptotic signal that protects normal cells from TNF injury in vitro can be shown to be operative in vivo...
  16. ncbi IL-1 and TNF receptor-deficient mice show decreased inflammation in an immune complex model of uveitis
    B E Brito
    Department of Ophthalmology, Casey Eye Institute, Oregon Health Sciences University, Portland 97201 4197, USA
    Invest Ophthalmol Vis Sci 40:2583-9. 1999
    ..To determine the role of interleukin-1 (IL-1) and tumor necrosis factor-alpha (TNF-alpha) in the induction of uveitis by a reverse passive Arthus reaction (RPAR)...
  17. ncbi Characterisation of receptor-specific TNFalpha functions in adipocyte cell lines lacking type 1 and 2 TNF receptors
    J K Sethi
    Division of Biological Sciences and Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    FEBS Lett 469:77-82. 2000
    ..These were established from wild type controls (TNFR1(+/+)R2(+/+)) and from mice lacking TNFR1 (TNFR1(-/-)), TNFR2 (TNFR2(-/-)) or both (TNFR1(-/-)R2(-/-))...
  18. ncbi Enhancement of MHC class I-stimulated alloresponses by TNF/TNF receptor (TNFR)1 interactions and of MHC class II-stimulated alloresponses by TNF/TNFR2 interactions
    G R Brown
    Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, 75390 9151, USA
    Eur J Immunol 30:2900-7. 2000
    ..host disease. The present studies were designed to evaluate whether TNF/TNF receptor (TNFR)1 and TNF/TNFR2 interactions were involved in the generation of allospecific T cell responses...
  19. pmc Critical roles for interleukin 1 and tumor necrosis factor alpha in antibody-induced arthritis
    Hong Ji
    Section on Immunology and Immunogenetics, Joslin Diabetes Center and Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    J Exp Med 196:77-85. 2002
    ..The variability in the requirement for TNF-alpha, reminiscent of that observed in treated rheumatoid arthritis patients, did not appear genetically programmed but related instead to subtle environmental changes...
  20. ncbi Roles for early response cytokines during Escherichia coli pneumonia revealed by mice with combined deficiencies of all signaling receptors for TNF and IL-1
    Joseph P Mizgerd
    Physiology Program, Harvard School of Public Health, Harvard Medical School, Boston, MA 02115, USA
    Am J Physiol Lung Cell Mol Physiol 286:L1302-10. 2004
    ..overlapping functions, we generated mice deficient in all of the three receptors mediating their effects (TNFR1, TNFR2, and IL-1RI)...
  21. pmc IL-1 mediates TNF-induced osteoclastogenesis
    Shi Wei
    Department of Pathology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 115:282-90. 2005
    ..Thus, IL-1 mediates the osteoclastogenic effect of TNF by enhancing stromal cell expression of RANKL and directly stimulating differentiation of osteoclast precursors...
  22. ncbi Tumor necrosis factor receptor 1 and 2 proteins are differentially regulated during Wallerian degeneration of mouse sciatic nerve
    Annette George
    Neurologische Klinik der Universität, Josef Schneider Str 11, 97080 Wurzburg, Germany
    Exp Neurol 192:163-6. 2005
    ..Here, we investigated local protein levels of the two known TNF receptors, TNF receptor 1 and 2 (TNFR1, TNFR2), on days 0, 1, 3, 7, 14, and 28 after unilateral crush or chronic constriction injury (CCI) of mouse sciatic ..
  23. ncbi Defective innate antibacterial host responses during murine Klebsiella pneumoniae bacteremia: tumor necrosis factor (TNF) receptor 1 deficiency versus therapy with anti-TNF-alpha
    Thomas A Moore
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48109 0642, USA
    Clin Infect Dis 41:S213-7. 2005
    ..These data indicate that the antibacterial host response is dysregulated in mice lacking TNFR1 or TNF-alpha bioactivity...
  24. pmc Lung NF-kappaB activation and neutrophil recruitment require IL-1 and TNF receptor signaling during pneumococcal pneumonia
    Matthew R Jones
    Physiology Program, Harvard School of Public Health, Boston, MA 02115, USA
    J Immunol 175:7530-5. 2005
    ..Thus, the combined deficiency of TNF and IL-1 signaling reduces innate immune responses to S. pneumoniae in the lungs, probably due to essential roles for these receptors in activating NF-kappaB...
  25. ncbi Innate stimuli accentuate end-organ damage by nephrotoxic antibodies via Fc receptor and TLR stimulation and IL-1/TNF-alpha production
    Yuyang Fu
    Division of Rheumatology, and Center for Immunology, University of Southwestern Medical Center, Dallas, TX 75390, USA
    J Immunol 176:632-9. 2006
    ....
  26. ncbi Tumor necrosis factor receptor 1 is a negative regulator of progenitor proliferation in adult hippocampal neurogenesis
    Robert E Iosif
    Laboratory of Neurogenesis and Cell Therapy, Section of Restorative Neurology, Wallenberg Neuroscience Center, University Hospital, SE 221 84 Lund, Sweden
    J Neurosci 26:9703-12. 2006
    ....
  27. doi Evoked pain behavior and spinal glia activation is dependent on tumor necrosis factor receptor 1 and 2 in a mouse model of bone cancer pain
    C Geis
    Department of Neurology, University of Wurzburg, Wurzburg, Germany
    Neuroscience 169:463-74. 2010
    ..Mechanisms by which TNF, through its receptor subtypes, TNF receptor 1 (TNFR1) and -2 (TNFR2), elicits altered sensation and pain behavior, are still incompletely understood...
  28. pmc Cloning and expression of cDNAs for two distinct murine tumor necrosis factor receptors demonstrate one receptor is species specific
    M Lewis
    Department of Molecular Biology, Genentech, Inc, South San Francisco, CA 94080
    Proc Natl Acad Sci U S A 88:2830-4. 1991
    ..This result suggests that the various activities of human tumor necrosis factor alpha reported in mice or in murine cell lines are probably mediated by mTNF-R1...
  29. ncbi Induction of apoptosis in mature T cells by tumour necrosis factor
    L Zheng
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 377:348-51. 1995
    ..Here we show that tumour necrosis factor (TNF) can mediate mature T-cell receptor-induced apoptosis through the p75 TNF receptor...
  30. pmc Monoclonal antibodies specific for murine p55 and p75 tumor necrosis factor receptors: identification of a novel in vivo role for p75
    K C Sheehan
    Center for Immunology, Washington University School of Medicine, St Louis, Missouri 63110
    J Exp Med 181:607-17. 1995
    Monoclonal antibodies (mAbs) specific for the murine p55 and p75 tumor necrosis factor (TNF) receptors were produced after immunization of Armenian hamsters with the purified soluble extracellular domains of each receptor protein...
  31. ncbi Decreased sensitivity to tumour-necrosis factor but normal T-cell development in TNF receptor-2-deficient mice
    S L Erickson
    Department of Cell Genetics, Genentech, South San Francisco, California 94080
    Nature 372:560-3. 1994
    ..TNF) elicits multiple biological effects through two distinct cell surface receptors, TNF-R1 (p55) and TNF-R2 (p75)...
  32. ncbi A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor
    M Rothe
    Department of Molecular Biology, Genentech, Incorporated, South San Francisco, California 94080
    Cell 78:681-92. 1994
    ..TRAF1 interacts with TNF-R2 indirectly through heterodimer formation with TRAF2...
  33. ncbi The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins
    M Rothe
    Department of Molecular Biology Tularik, Incorporated, South San Francisco, California 94080, USA
    Cell 83:1243-52. 1995
    The 75 kDa tumor necrosis factor receptor (TNFR2) transduces extracellular signals via receptor-associated cytoplasmic proteins. Two of these signal transducers, TRAF1 and TRAF2, were isolated and characterized previously...
  34. pmc Differentiation of follicular dendritic cells and full antibody responses require tumor necrosis factor receptor-1 signaling
    M Le Hir
    Swiss Institute of Technology, Institute of Toxicology, Schwerzenbach, Switzerland
    J Exp Med 183:2367-72. 1996
    ..Spleen morphology and antibody response were investigated in wild-type, TNFR1-/-, TNFR2-/- and TNF/LT alpha-/- mice immunized with SRBC...
  35. pmc Defective Peyer's patch organogenesis in mice lacking the 55-kD receptor for tumor necrosis factor
    B Neumann
    Institute for Medical Microbiology and Hygiene, Technical University of Munich, Germany
    J Exp Med 184:259-64. 1996
    Lymphotoxin alpha (LT-alpha) may form secreted homotrimers binding to p55 and p75 tumor necrosis factor (TNF) receptors or cell surface-bound heterotrimers with LT-beta that interact with the LT-beta receptor...
  36. ncbi TNF receptors in murine Candida albicans infection: evidence for an important role of TNF receptor p55 in antifungal defense
    S Steinshamn
    Institute of Cancer Research and Molecular Biology, University Medical Center, Trondheim, Norway
    J Immunol 157:2155-9. 1996
    TNF mediates multiple biologic activities through two distinct cell surface receptors, TNFR-p55 and TNFR-p75. TNF plays an important role in nonspecific resistance against the fungus Candida albicans...
  37. ncbi Ligand-induced formation of p55 and p75 tumor necrosis factor receptor heterocomplexes on intact cells
    J K Pinckard
    Department of Pathology, Center for Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 272:10784-9. 1997
    The p55 and p75 tumor necrosis factor receptors are known to mediate their effects on cells through distinct signaling pathways...
  38. ncbi A murine transmembrane tumor necrosis factor (TNF) transgene induces arthritis by cooperative p55/p75 TNF receptor signaling
    L Alexopoulou
    Department of Molecular Genetics, Hellenic Pasteur Institute, Athens, Greece
    Eur J Immunol 27:2588-92. 1997
    ..These results indicate that blocking the activities of both soluble and transmembrane TNF may be required to effectively neutralize the pathogenic potential of this cytokine in arthritis...
  39. ncbi TNF receptor-deficient mice reveal divergent roles for p55 and p75 in several models of inflammation
    J J Peschon
    Department of Molecular Immunology, Immunex Corp, Seattle, WA 98101, USA
    J Immunol 160:943-52. 1998
    ..cytokine TNF are mediated by two structurally related, but functionally distinct, receptors, p55 and p75, that are coexpressed on most cell types...
  40. ncbi Differential activities of secreted lymphotoxin-alpha3 and membrane lymphotoxin-alpha1beta2 in lymphotoxin-induced inflammation: critical role of TNF receptor 1 signaling
    R Sacca
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06520, USA
    J Immunol 160:485-91. 1998
    ..Secreted LT alpha3 can bind to two cell surface receptors, TNFR1 and TNFR2, while the membrane-bound heterotrimer LT alpha1beta2 has been shown to interact with a distinct receptor, LT ..
  41. ncbi Decreased resistance of TNF receptor p55- and p75-deficient mice to chronic toxoplasmosis despite normal activation of inducible nitric oxide synthase in vivo
    G S Yap
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institutes of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    J Immunol 160:1340-5. 1998
    ..in host defense to the intracellular parasite, Toxoplasma gondii, was investigated in mice lacking both the p55 and p75 receptors for this cytokine. Upon i.p...
  42. ncbi Severity of symptoms and demyelination in MOG-induced EAE depends on TNFR1
    H P Eugster
    Department of Internal Medicine, University Hospital, Zurich, Switzerland
    Eur J Immunol 29:626-32. 1999
    The individual role of tumor necrosis factor receptor 1 (TNFR1) and TNFR2 signaling in experimental autoimmune encephalomeylitis (EAE) was investigated using mice lacking TNFR1 (TNFR1-/-), TNFR2 (TNFR2-/-) as well as double receptor (..
  43. ncbi The p55 TNF-alpha receptor plays a critical role in T cell alloreactivity
    G R Hill
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 164:656-63. 2000
    ..We have studied this question by comparing normal mice with those lacking the p55 (p55 TNFR-/-) or p75 (p75 TNFR-/-) TNF-alpha receptors as donors in well-defined bone marrow transplant (BMT) models...
  44. ncbi Evidence that tristetraprolin is a physiological regulator of granulocyte-macrophage colony-stimulating factor messenger RNA deadenylation and stability
    E Carballo
    Office of Clinical Research and Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Blood 95:1891-9. 2000
    ..TTP appears to be a physiological regulator of GM-CSF mRNA deadenylation and stability. (Blood. 2000;95:1891-1899)..
  45. pmc Keratin-dependent, epithelial resistance to tumor necrosis factor-induced apoptosis
    C Caulin
    Cancer Research Center, The Burnham Institute, La Jolla, CA 92037, USA
    J Cell Biol 149:17-22. 2000
    ..by macrophages and T lymphocytes that acts through two distinct receptors, TNFR1 (60 kD, CD120a) and TNFR2 (80 kD, CD120b), to affect cellular proliferation, differentiation, survival, and cell death...
  46. pmc Endogenous tumor necrosis factor protects the adult cardiac myocyte against ischemic-induced apoptosis in a murine model of acute myocardial infarction
    K M Kurrelmeyer
    Winters Center for Heart Failure Research, Cardiology Section, Veterans Affairs Medical Center, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 97:5456-61. 2000
    ..TTC) staining in wild-type (both TNF receptors present) and mice lacking either the type 1 (TNFR1), type 2 (TNFR2), or both TNF receptors (TNFR1/TNFR2)...
  47. ncbi Tumor necrosis factor and the p55TNF receptor are required for optimal development of the marginal sinus and for migration of follicular dendritic cell precursors into splenic follicles
    M Pasparakis
    Laboratory of Molecular Genetics, Hellenic Pasteur Institute, Athens, 115 21, Greece
    Cell Immunol 201:33-41. 2000
    ....
  48. ncbi Divergent roles for p55 and p75 tumor necrosis factor receptors in the pathogenesis of MOG(35-55)-induced experimental autoimmune encephalomyelitis
    G C Suvannavejh
    Department of Microbiology Immunology, Interdepartmental Immunology Center, Northwestern University Medical School, 303 E Chicago Avenue, Illinois 60611, USA
    Cell Immunol 205:24-33. 2000
    ..of autoreactive effector cells, we assessed the roles of the p55 (TNFR1/Tnfrsf1a/CD120a) and p75 (TNFR2/Tnfrsf1b/CD120b) TNF receptors in the pathogenesis of MOG(35-55)-induced experimental autoimmune encephalomyelitis (EAE)...
  49. pmc Impaired preneoplastic changes and liver tumor formation in tumor necrosis factor receptor type 1 knockout mice
    B Knight
    University of Western Australia, Department of Biochemistry, Nedlands WA 6907, Australia
    J Exp Med 192:1809-18. 2000
    ..The TNF inflammatory pathway may be a target for therapeutic intervention during the early stages of liver carcinogenesis...
  50. pmc Uncoupling the proinflammatory from the immunosuppressive properties of tumor necrosis factor (TNF) at the p55 TNF receptor level: implications for pathogenesis and therapy of autoimmune demyelination
    G Kassiotis
    Laboratory of Molecular Genetics, Hellenic Pasteur Institute, Athens 115 21, Greece
    J Exp Med 193:427-34. 2001
    ..Thus, blocking the function of the p55 TNFR in autoimmune demyelination may inhibit the noxious proinflammatory activities of TNF without compromising its immunosuppressive properties...
  51. ncbi Genetic deletion of the tumor necrosis factor receptor p60 or p80 abrogates ligand-mediated activation of nuclear factor-kappa B and of mitogen-activated protein kinases in macrophages
    A Mukhopadhyay
    Cytokine Research Section, Department of Bioimmunotherapy, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 276:31906-12. 2001
    ..These effects are mediated through two different receptors, TNFR1 and TNFR2 (also called p60 and p80, respectively), with p60 receptor being expressed on all cell types and p80 receptor only ..
  52. ncbi TNF type 2 receptor (p75) lowers the threshold of T cell activation
    E Y Kim
    Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia, Canada
    J Immunol 167:6812-20. 2001
    ..Here the role of TNFR2 (p75) as a putative costimulatory receptor for T cell activation was examined...
  53. ncbi Role of tumor necrosis factor receptor 2 (TNFR2) in colonic epithelial hyperplasia and chronic intestinal inflammation in mice
    Emiko Mizoguchi
    Center for the Study of Inflammatory Bowel Disease, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    Gastroenterology 122:134-44. 2002
    Tumor necrosis factor (TNF) induces multiple effects including cell proliferation and death by ligation with TNF receptor type II (TNFR2). We studied the role of TNFR2 in chronic inflammation-induced colonic epithelial alteration.
  54. ncbi Neurodegenerative and neuroprotective effects of tumor Necrosis factor (TNF) in retinal ischemia: opposite roles of TNF receptor 1 and TNF receptor 2
    Valerie Fontaine
    Institute of Cell Biology and Immunology, University of Stuttgart, 70569 Stuttgart, Germany
    J Neurosci 22:RC216. 2002
    ..Selective inhibition of TNF-R1 function may represent a new approach to reduce ischemia-induced neuronal damage, being potentially superior to strategies aimed at suppression of TNF activity in general...
  55. pmc Requirement for tumor necrosis factor receptor 2 expression on vascular cells to induce experimental cerebral malaria
    Benjamin Stoelcker
    Institute of Pathology Tumor Immunology, University of Regensburg, 93042 Regensburg, Germany
    Infect Immun 70:5857-9. 2002
    Using tumor necrosis factor receptor type 2 (TNFR2)-deficient mice and generating bone marrow chimeras which express TNFR2 on either hematopoietic or nonhematopoietic cells, we demonstrated the requirement for TNFR2 expression on tissue ..
  56. ncbi Tumor necrosis factor receptors 1 and 2 differentially regulate survival, cardiac dysfunction, and remodeling in transgenic mice with tumor necrosis factor-alpha-induced cardiomyopathy
    Yoshihiro Higuchi
    Center for Translational Medicine, Department of Medicine, Jefferson Medical College, Philadelphia 19107, USA
    Circulation 109:1892-7. 2004
    Tumor necrosis factor (TNF)-alpha plays a pathophysiological role in heart failure. Although both TNF receptor 1 (TNFR1) and 2 (TNFR2) are present in the heart, comparatively little is known about the role of TNFR2.
  57. ncbi Tumor necrosis factor (TNF)-mediated neuroprotection against glutamate-induced excitotoxicity is enhanced by N-methyl-D-aspartate receptor activation. Essential role of a TNF receptor 2-mediated phosphatidylinositol 3-kinase-dependent NF-kappa B pathway
    Lara Marchetti
    Institute of Cell Biology and Immunology, University of Stuttgart, Allmandring 31, D 70569 Stuttgart, Germany
    J Biol Chem 279:32869-81. 2004
    ..TNFR) exhibit antagonistic functions during neurodegenerative processes in vivo with TNFR1 aggravating and TNFR2 reducing neuronal cell loss, respectively...
  58. ncbi Critical role of TNF receptor type-2 (p75) as a costimulator for IL-2 induction and T cell survival: a functional link to CD28
    Edward Y Kim
    Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia, Canada
    J Immunol 173:4500-9. 2004
    ..In this study the role of p75 as a T cell costimulatory molecule in controlling cell fate during TCR/CD28-mediated stimulation was examined...
  59. pmc Role of tumor necrosis factor receptors in regulating CD8 T-cell responses during acute lymphocytic choriomeningitis virus infection
    M Suresh
    Department of Pathobiological Sciences, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    J Virol 79:202-13. 2005
    ..responses to lymphocytic choriomeningitis virus (LCMV) with wild-type, p55R-deficient (p55(-/-)), p75R-deficient (p75(-/-)), and p55R- and p75R-deficient (DKO) mice...
  60. pmc Renal cell-expressed TNF receptor 2, not receptor 1, is essential for the development of glomerulonephritis
    Volker Vielhauer
    Center of Excellence in Vascular Biology, Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 115:1199-209. 2005
    ..and immunosuppressive properties that may segregate at the level of the 2 TNF receptors (TNFRs), TNFR1 and TNFR2. TNFR1-deficient mice subjected to immune complex-mediated glomerulonephritis developed less proteinuria and ..
  61. ncbi TNF receptor type 2 (p75) functions as a costimulator for antigen-driven T cell responses in vivo
    Edward Y Kim
    Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia, Canada
    J Immunol 176:1026-35. 2006
    ..We demonstrate using the MHC class I-restricted 2C TCR and MHC class II-restricted AND TCR transgenic systems that TNFR2 regulates the threshold for clonal expansion of CD4 and CD8 T cell subsets in response to cognate Ag...
  62. ncbi Urothelial lesion formation is mediated by TNFR1 during neurogenic cystitis
    Michael C Chen
    Departments of Urology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Am J Physiol Renal Physiol 291:F741-9. 2006
    ..In urothelial cultures, only siRNAs targeting TNFR1, but not TNFR2, blocked TNF-induced apoptosis, indicating a primary role for TNFR1...
  63. pmc Differential functions of tumor necrosis factor receptor 1 and 2 signaling in ischemia-mediated arteriogenesis and angiogenesis
    Dianhong Luo
    Interdepartmental Program in Vascular Biology and Transplantation, Department of Pathology, Yale University School of Medicine, BCMM 454, 295 Congress Ave, New Haven, CT 06510, USA
    Am J Pathol 169:1886-98. 2006
    We have previously shown that tumor necrosis factor (TNF) acts via its two receptors TNFR1 and TNFR2 to elicit distinct signaling pathways in vascular endothelial cells (ECs)...
  64. ncbi Tumor necrosis factor-alpha receptor p75 is required in ischemia-induced neovascularization
    David A Goukassian
    Division of Cardiovascular Diseases, Department of Medicine, Caritas St Elizabeth s Medical Center, Boston, Mass, USA
    Circulation 115:752-62. 2007
    ..Little is known about the role of TNF-alpha receptors (TNFR1/p55 and TNFR2/p75) in angiogenic signaling.
  65. ncbi Tumor necrosis factor-alpha is toxic via receptor 1 and protective via receptor 2 in a murine model of myocardial infarction
    Yoshiya Monden
    Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, 3 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Am J Physiol Heart Circ Physiol 293:H743-53. 2007
    ..TNF-alpha initiates its biological effects by binding two distinct receptors: R1 (p55) and R2 (p75)...
  66. ncbi Tumor necrosis factor receptor 2-mediated tumor suppression is nitric oxide dependent and involves angiostasis
    Xueqiang Zhao
    National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China
    Cancer Res 67:4443-50. 2007
    ..Although most of its functions are attributed to TNF receptor 1 (TNFR1), the independent role of TNFR2 is still largely unknown...
  67. ncbi Interaction of TNF with TNF receptor type 2 promotes expansion and function of mouse CD4+CD25+ T regulatory cells
    Xin Chen
    Laboratory of Molecular Immunoregulation, Basic Research Program, SAIC Frederick, National Cancer Institute, Frederick, MD 21702, USA
    J Immunol 179:154-61. 2007
    ..states, mouse peripheral CD4(+)CD25(+) T regulatory cells (Tregs) expressed remarkably higher surface levels of TNFR2 than CD4(+)CD25(-) T effector cells (Teffs)...
  68. ncbi The alpha1beta1 integrin and TNF receptor II protect airway CD8+ effector T cells from apoptosis during influenza infection
    Martin V Richter
    Department of Microbiology and Immunology, University of Rochester, Rochester, NY 14642, USA
    J Immunol 179:5054-63. 2007
    ..We propose that TNFR-II and the VLA-1 synergize to protect effector CD8 T cells in the infected airways from apoptosis during the acute infection...
  69. pmc TNF-alpha is critical for antitumor but not antiviral T cell immunity in mice
    Thomas Calzascia
    The Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, Toronto, Ontario, Canada
    J Clin Invest 117:3833-45. 2007
    ..Here, we show a role for TNF-alpha and its receptors, TNFR1 and TNFR2, specifically in antitumor immunity...
  70. pmc Murine beta-defensin 2 promotes TLR-4/MyD88-mediated and NF-kappaB-dependent atypical death of APCs via activation of TNFR2
    Arya Biragyn
    Laboratory of Immunology, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    J Leukoc Biol 83:998-1008. 2008
    ..We demonstrate that mDF2beta triggers a TNFR2-mediated signaling cascade of "self-destruction" through up-regulation of membrane-bound TNF-alpha and TNFR2...
  71. pmc Endothelial cell activation leads to neutrophil transmigration as supported by the sequential roles of ICAM-2, JAM-A, and PECAM-1
    Abigail Woodfin
    Barts and the London School of Medicine and Dentistry, Queen Mary University of London, William Harvey Research Institute, London, United Kingdom
    Blood 113:6246-57. 2009
    ..Using a cell-transfer technique, transmigration responses of wild-type and TNF-alpha p55/p75 receptor-deficient leukocytes (TNFR(-/-)) through mouse cremasteric venules were quantified by fluorescence ..
  72. doi Upregulation of TNF receptor type 2 in human and experimental renal allograft rejection
    U Hoffmann
    Department of Internal Medicine II, University of Regensburg, Regensburg, Germany
    Am J Transplant 9:675-86. 2009
    An important role of TNF interacting with TNFR2 has been shown in different models of ischemic, nephrotoxic and immune-mediated renal injury...
  73. doi Blockade of tumor necrosis factor alpha signaling in tumor-associated macrophages as a radiosensitizing strategy
    Yuru Meng
    Department of Radiation and Cellular Oncology and Department of Medicine, Section of Hematology Oncology, The University of Chicago, Chicago, Illinois 60637, USA
    Cancer Res 70:1534-43. 2010
    ..Our findings offer a mechanistic basis to target macrophage populations generally or TNFalpha-induced macrophage VEGF specifically as tractable strategies to improve the efficacy of radiotherapy...
  74. doi Activation of TNF receptor 2 in microglia promotes induction of anti-inflammatory pathways
    Caterina Veroni
    Departments of Cell Biology and Neurosciences, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    Mol Cell Neurosci 45:234-44. 2010
    ..We found that microglia upregulate TNFR2 mRNA and protein and shed large amounts of soluble TNFR2, but not TNFR1, in response to pro-inflammatory stimuli ..
  75. pmc TNFR2 interposes the proliferative and NF-κB-mediated inflammatory response by podocytes to TNF-α
    Leslie A Bruggeman
    Department of Medicine and Rammelkamp Center for Education and Research, MetroHealth Medical Center, Case Western Reserve University School of Medicine, Cleveland, OH 44109, USA
    Lab Invest 91:413-25. 2011
    The development of proliferative podocytopathies has been linked to ligation of tumor necrosis factor receptor 2 (TNFR2) expressed on the renal parenchyma; however, the TNFR2-positive cells within the kidney responsible for podocyte ..
  76. doi TNFR1 delivers pro-survival signals that are required for limiting TNFR2-dependent activation-induced cell death (AICD) in CD8+ T cells
    Yuh Ching Twu
    Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC, Canada
    Eur J Immunol 41:335-44. 2011
    ..We have shown that TNFR2 regulates T-cell activation by lowering the activation threshold and providing costimulatory signaling...
  77. pmc In vivo systems analysis identifies spatial and temporal aspects of the modulation of TNF-α-induced apoptosis and proliferation by MAPKs
    Ken S Lau
    Molecular Pathology Unit, Center for Cancer Research, and Center for Systems Biology, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Sci Signal 4:ra16. 2011
    ..This study lays a foundation for the use of systems-based approaches to understand how dysregulation of the cellular network state underlies complex diseases...
  78. pmc Colitogenic role of tumour necrosis factor (TNF) receptors in trinitrobenzene sulphonic acid colitis: TNF-R1 ablation does not affect systemic inflammatory response
    Y Yang
    Department of Molecular Immunology, Institute of Basic Medical Sciences, Beijing, China
    Clin Exp Immunol 165:372-82. 2011
    ..These findings suggest that either TNF-R1 or TNF-R2 plays a pathogenic role in the pathology of colitis and TNF signalling via TNF-R1 or TNF-R2 alone is not sufficient for inducing mucosal damage...
  79. pmc Constitutive intestinal NF-κB does not trigger destructive inflammation unless accompanied by MAPK activation
    Monica Guma
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    J Exp Med 208:1889-900. 2011
    ..Inflammation is driven by massive TNF production, which requires additional activation of p38 and extracellular-signal-regulated kinase mitogen-activated protein kinases (MAPKs)...
  80. doi TNF-α/Fas-RIP-1-induced cell death signaling separates murine hematopoietic stem cells/progenitors into 2 distinct populations
    Yechen Xiao
    Oncology Institute, Cardinal Bernardin Cancer Center, Loyola University Medical Center, Maywood, IL 60153, USA
    Blood 118:6057-67. 2011
    ..Tak1 mediates a critical survival signal, which protects against both TNF-α/Fas-RIP-1-dependent necroptosis and TNF-α/Fas-independent apoptosis in HSPCs...
  81. pmc Breaking the 'harmony' of TNF-α signaling for cancer treatment
    S P Sasi
    Center of Cancer Systems Biology, Brighton, MA 02135, USA
    Oncogene 31:4117-27. 2012
    Tumor necrosis factor-alpha (TNF-α) binds to two distinct receptors, TNFR1/p55 and TNFR2/p75...
  82. pmc TNFR1-activated reactive oxidative species signals up-regulate osteogenic Msx2 programs in aortic myofibroblasts
    Chung Fang Lai
    Department of Internal Medicine, Washington University in St Louis, Missouri 63110, USA
    Endocrinology 153:3897-910. 2012
    ..By contrast, TNF-inducible Msx2 expression was not reduced in TNFR2(-/-) cells...
  83. pmc TNFR2 is critical for the stabilization of the CD4+Foxp3+ regulatory T. cell phenotype in the inflammatory environment
    Xin Chen
    Basic Science Program, Science Applications International Corporation Frederick, National Cancer Institute Frederick, Frederick, MD 21702, USA
    J Immunol 190:1076-84. 2013
    ..In this study, we found that the proportion of Tregs in mouse strains deficient in TNFR2 or its ligands was reduced in the thymus and peripheral lymphoid tissues, suggesting a potential role of TNFR2 in ..
  84. pmc Oligodendrocyte apoptosis and primary demyelination induced by local TNF/p55TNF receptor signaling in the central nervous system of transgenic mice: models for multiple sclerosis with primary oligodendrogliopathy
    K Akassoglou
    Department of Molecular Genetics, Hellenic Pasteur Institute, Athens, Greece
    Am J Pathol 153:801-13. 1998
    ....
  85. ncbi Tumor necrosis factor receptor 2 plays a minor role for mycobacterial immunity
    M Jacobs
    Department of Immunology, University of Cape Town, South Africa
    Pathobiology 68:68-75. 2000
    ..Therefore, anti-mycobacterial immunity is largely dependent on TNF signalling via the TNF-R1, while activation of TNF-R2 plays a minor role...
  86. ncbi Role of lymphotoxin and the type I TNF receptor in the formation of germinal centers
    M Matsumoto
    Center for Immunology and Howard Hughes Medical Institute, Washington University School of Medicine, St Louis, MO 63110, USA
    Science 271:1289-91. 1996
    ..Germinal center formation was restored in LT-alpha-deficient mice by transplantation of normal bone marrow, indicating that the LT-alpha-expressing cells required to establish this lymphoid structure are derived from bone marrow...
  87. ncbi TNF receptor type 2 mediates thymocyte proliferation independently of TNF receptor type 1
    M Grell
    Institute of Cell Biology and Immunology, University of Stuttgart, Germany
    Eur J Immunol 28:257-63. 1998
    ....
  88. ncbi Crucial role of TNF receptor type 1 (p55), but not of TNF receptor type 2 (p75), in murine toxoplasmosis
    M Deckert-Schlüter
    Institut für Neuropathologie, Universitatskliniken Bonn, Germany
    J Immunol 160:3427-36. 1998
    ..its biologic activity through two distinct receptors, TNF receptor type 1 (TNFR1, p55) and TNF receptor type 2 (TNFR2, p75)...
  89. ncbi Analysis of liver regeneration in mice lacking type 1 or type 2 tumor necrosis factor receptor: requirement for type 1 but not type 2 receptor
    Y Yamada
    Department of Pathology, University of Washington School of Medicine, Seattle, WA 98195 7705, USA
    Hepatology 28:959-70. 1998
    ..Inhibition of AP-1 and C/EBP binding and in the expression of c-jun and c-myc mRNA in the first 4 hours after PH, as well as the apparent lack of Fos in AP-1 complexes, had no effect on the timing or extent of DNA replication...
  90. ncbi Autoimmune intestinal pathology induced by hsp60-specific CD8 T cells
    U Steinhoff
    Department of Immunology, Max Planck Institute of Infection Biology, Germany
    Immunity 11:349-58. 1999
    ..This report demonstrates that CD8 T cells with defined antigen specificity cause intestinal inflammation, emphasizing a link between infection and autoimmune disease...
  91. pmc A role for tumor necrosis factor receptor type 1 in gut-associated lymphoid tissue development: genetic evidence of synergism with lymphotoxin beta
    P A Koni
    Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Exp Med 187:1977-83. 1998
    ..A complete lack of only PPs in mice heterozygous for both ltalpha and ltbeta, but not ltalpha or ltbeta alone, suggests a similar two-ligand phenomenon in PP development and may explain the incomplete lack of PPs seen in tnfr1-/- mice...
  92. pmc Impairment of TNF-receptor-1 signaling but not fas signaling diminishes T-cell apoptosis in myelin oligodendrocyte glycoprotein peptide-induced chronic demyelinating autoimmune encephalomyelitis in mice
    R Bachmann
    Institute of Neurology, University of Vienna, Schwarzspanierstrasse 17, 1090 Wien, Austria
    Am J Pathol 154:1417-22. 1999
    ..Our study thus identified the TNF receptor 1 signaling pathway as one mechanism responsible for the removal of T lymphocytes from inflammatory demyelinating lesions of the central nervous system...
  93. pmc Tumor necrosis factor alpha is a key component in the obesity-linked elevation of plasminogen activator inhibitor 1
    F Samad
    The Scripps Research Institute, Department of Vascular Biology, 10550 North Torrey Pines Road, VB 3, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 96:6902-7. 1999
    ..TNFRs indicate that TNF-alpha signaling of PAI-1 in adipose tissue can be mediated by either the p55 or the p75 TNFR. However, TNF-alpha signaling of TGF-beta mRNA expression in adipose tissue is mediated exclusively via the p55 ..
  94. pmc Interleukin-1 and tumor necrosis factor receptor signaling is not required for bacteria-induced osteoclastogenesis and bone loss but is essential for protecting the host from a mixed anaerobic infection
    C P Chen
    Department of Periodontology and Oral Biology, Boston University School of Dental Medicine, Boston University, Boston, Massachusetts, USA
    Am J Pathol 155:2145-52. 1999
    ..six anaerobic pathogens, in mice with functional deletions of receptors to IL-1 (IL-1RI(-/-)), TNF (TNFRp55(-/-)-p75(-/-)), or both (TNFRp55(-/-)-IL-1RI(-/-))...
  95. ncbi Islet-specific expression of IL-10 promotes diabetes in nonobese diabetic mice independent of Fas, perforin, TNF receptor-1, and TNF receptor-2 molecules
    B Balasa
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunol 165:2841-9. 2000
    ....
  96. ncbi The importance of IL-1 beta and TNF-alpha, and the noninvolvement of IL-6, in the development of monoclonal antibody-induced arthritis
    Takashi Kagari
    Biological Research Laboratories, Sankyo Co, Ltd, Tokyo, Japan
    J Immunol 169:1459-66. 2002
    ..Because arthritis was also developed in SCID mice, the development of arthritis in the Ab-induced mice model is due to a mechanism that does not involve T or B cells...
  97. pmc Genomic profiling of tumor necrosis factor alpha (TNF-alpha) receptor and interleukin-1 receptor knockout mice reveals a link between TNF-alpha signaling and increased severity of 1918 pandemic influenza virus infection
    Sarah E Belisle
    Department of Microbiology, University of Washington, Box 358070, Seattle, WA 98195 8070, USA
    J Virol 84:12576-88. 2010
    ..These findings suggest that manipulation of these pathways may have therapeutic benefit...
  98. ncbi Paradoxical anti-inflammatory actions of TNF-alpha: inhibition of IL-12 and IL-23 via TNF receptor 1 in macrophages and dendritic cells
    Maria Zakharova
    Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Immunol 175:5024-33. 2005
    ..This nonapoptotic anti-inflammatory regulation of IL-12 and IL-23 is an important addition to the multitude of TNF-alpha-induced responses determined by cell-specific receptor signaling...
  99. doi B-cells and IL-4 promote methylcholanthrene-induced carcinogenesis but there is no evidence for a role of T/NKT-cells and their effector molecules (Fas-ligand, TNF-α, perforin)
    Thomas Kammertoens
    Institut fur Immunologie, Charite, Campus Benjamin Franklin, Berlin, Germany
    Int J Cancer 131:1499-508. 2012
    ....
  100. pmc Soluble TNF receptors are associated with infarct size and ventricular dysfunction in ST-elevation myocardial infarction
    Lennart Nilsson
    Division of Cardiology, Department of Medical and Health Sciences, Linkoping University, Linkoping, Sweden
    PLoS ONE 8:e55477. 2013
    ....
  101. ncbi Mice lacking both TNFalpha receptors show increased constitutive expression of IFNgamma: a possible reason for lack of protection from fumonisin B1 hepatotoxicity
    Raghubir P Sharma
    Department of Physiology and Pharmacology, College of Veterinary Medicine, The University of Georgia, Athens, GA 30602 7389, USA
    Cytokine 34:260-70. 2006
    ....

Research Grants33

  1. Defending Against Systemic Mycoses
    GEORGE DEEPE; Fiscal Year: 2008
    ..The collaborative and synergistic effort manifested by this group of investigators will provide new and exciting information regarding prevention and/or treatment of these problematic fungi. ..
  2. PROTECTIVE ANTIGENS FROM HISTOPLASMA CAPSULATUM
    GEORGE DEEPE; Fiscal Year: 2007
    ..abstract_text> ..
  3. Direct Regulation of CD8 T Cells by Interferon gamma
    Marulasiddappa Suresh; Fiscal Year: 2010
    ..These studies should aid in the development of vaccines against arena viruses in particular and other viruses in general. ..
  4. Enhancement of CD8 T Cell Immunity by IL-7 Therapy
    Marulasiddappa Suresh; Fiscal Year: 2008
    ..The proposed studies should aid in the rational design of vaccines that can engender potent CDS T cell memory and protect against poxvirus and arenaviral infections. [unreadable] [unreadable] [unreadable]..
  5. Transport of TNFalpha across the BBB
    Weihong Pan; Fiscal Year: 2008
    ..To identify the roles of p55- and p75-receptors, we will study TNFa transport in the presence of receptor antibodies and in the receptor knockout mice...
  6. Transport of neurotrophic cytokines after spinal cord injury
    Weihong Pan; Fiscal Year: 2007
    ..Understanding the mechanisms of cytokine transport at this regulatory interface would help in the design of new approaches to treat SCI. ..
  7. 2008 Biology of Acute Respiratory Infections Gordon Research Conference
    JOSEPH MIZGERD; Fiscal Year: 2007
    ..End of Abstract) [unreadable] [unreadable] [unreadable]..
  8. TUMOR NECROSIS FACTOR INVOLVEMENT IN FUMONISIN TOXICITY
    RAGHUBIR SHARMA; Fiscal Year: 2001
    ..Results will help in defining the mechanism(s) of fumonisin toxicity, causes of species-specificity, and provide a better appraisal of risk in humans, including modification of fumonisin response by gram-negative infections. ..
  9. Cell Specific Responses to TNF-alpha in Lung Fibrosis
    Gloria Pryhuber; Fiscal Year: 2009
    ..Lung disease caused by inhaled dust is a significant world wide health problem. This proposal will identify new targets for therapy of these chronic and often deadly diseases with reduced side effects. ..
  10. T reg Cells in Myocarditis
    Sally A Huber; Fiscal Year: 2010
    ..Determine whether the T reg cells are antigen specific (virus), cardiovascular specific (autoimmunity), or non-antigen specific. ..
  11. Regulation of TRAIL-induced apoptosis
    Francis Chan; Fiscal Year: 2009
    ..Our experiments may also provide a useful diagnostic tool to determine response of cancers to treatments involving TRAIL or agonist TRAIL antibodies. ..
  12. Transcriptional regulation in chronic renal disease pathogenesis
    LESLIE BRUGGEMAN; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  13. Progenitor cell pretreatment against acute surgical I/R
    Daniel Meldrum; Fiscal Year: 2008
    ..abstract_text> ..
  14. Sex in Myocarditis
    Sally Huber; Fiscal Year: 2008
    ..By understanding the factors controlling virus infection and induction of innate immunity, better mechanism for controlling viral disease should be possible. ..
  15. Novel Mouse Model to Dissect Alzheimer's Disease Pathophysiology
    William Bowers; Fiscal Year: 2008
    ..abstract_text> ..
  16. Pre-association and Signaling by TNF-like Receptors
    Francis Chan; Fiscal Year: 2003
    ..The second part of this proposal attempts to elucidate the mechanism by which TNFR coordinates the recruitment of these signaling proteins. ..
  17. RSV AND ASTHMA
    David Broide; Fiscal Year: 2003
    ..Overall these studies will contribute to our understanding of the mechanism of eosinophilic inflammation during RSV infection and suggest candidate vaccine strategies to inhibit RSV infection and airway inflammation. ..
  18. EXPERIMENTAL RADIOTHERAPY--CARCINOGENESIS, AND PROTECTOR
    DAVID GRDINA; Fiscal Year: 2003
    ..abstract_text> ..
  19. Role of Programmed Necrosis in Immune Responses
    Francis Chan; Fiscal Year: 2006
    ..Moreover, controlling cell death may offer a novel approach to treating autoimmune diseases. [unreadable] [unreadable]..
  20. Akt activation sustains silica induced inflammation
    CELINE BEAMER; Fiscal Year: 2006
    ..abstract_text> ..
  21. TNFR ASSOCIATED FACTOR IN PULMONARY RESPONSE TO TNF-A
    Gloria Pryhuber; Fiscal Year: 2003
    ..The proposed studies will demonstrate the cellular function of TRAF1 in vitro and the role of TRAF1 expression in vivo in transgenic overexpression and ablation models stressed by hyperoxia. ..
  22. Delayed Radioprotection by Thiols
    DAVID GRDINA; Fiscal Year: 2006
    ..Two, elevation in MnSOD level without a concomitant increase in enzymatic activity can result from nitration of MnSOD by peroxynitrite (ONOO-). ..
  23. Epo-dependent JAK2 Signaling in Painful Neuropathy
    WENDY CAMPANA; Fiscal Year: 2006
    ..The experiments will provide new information on the basic mechanisms of nerve injury and pain, and there from, new rationale for development of novel neuroprotective strategies for preventing chronic neuropathic pain. ..
  24. CDI and Gamma Delta+ in Viral Myocarditis
    Sally Huber; Fiscal Year: 2005
    ..abstract_text> ..
  25. Sex in Viral Myocarditis
    Sally Huber; Fiscal Year: 2004
    ..These studies may provide new insights as to how viruses affect developing host defense responses and how hormones can modulate this initial response. ..
  26. CD4+ T CELLS PROMOTE EARLY ATHEROSCLEROSIS
    Sally Huber; Fiscal Year: 2002
    ..Specific Aim 3 will investigate the role of CD4+ T cells in atherogenesis and evaluate whether these cells promote Th1 cell dominance. ..
  27. ENDOTHELIUM--SIGNALING FROM MAST CELLS TO EOSINOPHILS
    David Broide; Fiscal Year: 2002
    ....
  28. T cell Function in Murine Model of Multiple Sclerosis
    Moses Rodriguez; Fiscal Year: 2010
    ..The findings are expected to provide new insights into the pathogenesis of axonal and neuronal injury in demyelinating disorders such as multiple sclerosis. ..
  29. TNRF1 Signaling Resistance in Ischemic Human Female Myocardium
    Daniel R Meldrum; Fiscal Year: 2010
    ..that TNF itself may have beneficial or detrimental effects depending on which of its receptors (TNFR1 or TNFR2) is activated...
  30. Eosinophil Trafficking
    David Broide; Fiscal Year: 2005
    ..Overall, these studies should improve our understanding of the molecular mechanism of eosinophil recruitment in vivo and its effect on airway structure and function. ..
  31. IMMUNE PROMOTION OF REMYELINATION
    Moses Rodriguez; Fiscal Year: 2008
    ..Our findings are expected to provide new insights into the enhancement of remyelination in diseases such as multiple sclerosis. [unreadable] [unreadable]..
  32. Biomarkers in sputum in COPD
    David Broide; Fiscal Year: 2005
    ..abstract_text> ..