Tnfrsf1a

Summary

Gene Symbol: Tnfrsf1a
Description: tumor necrosis factor receptor superfamily, member 1a
Alias: CD120a, FPF, TNF-R, TNF-R-I, TNF-R1, TNF-R55, TNF-alphaR1, TNFAR, TNFR60, TNFRI, TNFRp55, TNFalpha-R1, Tnfr-2, Tnfr1, p55, p55-R, tumor necrosis factor receptor superfamily member 1A, TNF receptor alpha chain, TNF-RI, TNF-alpha-R1, TNFR-I, p60, tumor necrosis factor receptor 1, tumor necrosis factor receptor type I
Species: mouse

Top Publications

  1. pmc TNF-alpha is a critical negative regulator of type 1 immune activation during intracellular bacterial infection
    Anna Zganiacz
    Infectious Diseases Division, Centre for Gene Therapeutics, and Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    J Clin Invest 113:401-13. 2004
  2. ncbi Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU-rich elements: implications for joint and gut-associated immunopathologies
    D Kontoyiannis
    Laboratory of Molecular Genetics, Hellenic Pasteur Institute, Athens, Greece
    Immunity 10:387-98. 1999
  3. pmc TGF-beta-activated kinase 1 signaling maintains intestinal integrity by preventing accumulation of reactive oxygen species in the intestinal epithelium
    Rie Kajino-Sakamoto
    Department of Environmental and Molecular Toxicology, North Carolina State University, Raleigh, NC 27695, USA
    J Immunol 185:4729-37. 2010
  4. pmc Kinase RIP3 is dispensable for normal NF-kappa Bs, signaling by the B-cell and T-cell receptors, tumor necrosis factor receptor 1, and Toll-like receptors 2 and 4
    Kim Newton
    Molecular Oncology Department, Genentech, Inc, South San Francisco, California 94080, USA
    Mol Cell Biol 24:1464-9. 2004
  5. ncbi The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses
    David L Boone
    Department of Medicine, University of California at San Francisco, San Francisco, California 94143 0451, USA
    Nat Immunol 5:1052-60. 2004
  6. pmc Deletion of tumor necrosis factor-alpha receptor 1 (TNFR1) protects against diet-induced obesity by means of increased thermogenesis
    Talita Romanatto
    Laboratory of Cell Signaling, University of Campinas, 13084 761 São Paulo, Brazil
    J Biol Chem 284:36213-22. 2009
  7. ncbi Tumor necrosis factor (TNF) ligand and TNF receptor deficiency affects sleep and the sleep EEG
    Tom Deboer
    Institute of Pharmacology and Toxicology, CH 8057, Switzerland
    J Neurophysiol 88:839-46. 2002
  8. pmc The caspase-cleaved form of LYN mediates a psoriasis-like inflammatory syndrome in mice
    Sandrine Marchetti
    INSERM, U895, Centre Méditerranéen de Médecine Moléculaire C3M, Team 2, Nice, France
    EMBO J 28:2449-60. 2009
  9. pmc Tumor necrosis factor restricts hematopoietic stem cell activity in mice: involvement of two distinct receptors
    Cornelis J H Pronk
    Hematopoietic Stem Cell Laboratory, Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund University, 221 84 Lund, Sweden
    J Exp Med 208:1563-70. 2011
  10. doi TNF-α/Fas-RIP-1-induced cell death signaling separates murine hematopoietic stem cells/progenitors into 2 distinct populations
    Yechen Xiao
    Oncology Institute, Cardinal Bernardin Cancer Center, Loyola University Medical Center, Maywood, IL 60153, USA
    Blood 118:6057-67. 2011

Research Grants

Detail Information

Publications181 found, 100 shown here

  1. pmc TNF-alpha is a critical negative regulator of type 1 immune activation during intracellular bacterial infection
    Anna Zganiacz
    Infectious Diseases Division, Centre for Gene Therapeutics, and Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    J Clin Invest 113:401-13. 2004
    ..activation at least in part by suppressing T cell proliferation, and this suppression involved both TNF receptor p55 and TNF receptor p75...
  2. ncbi Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU-rich elements: implications for joint and gut-associated immunopathologies
    D Kontoyiannis
    Laboratory of Molecular Genetics, Hellenic Pasteur Institute, Athens, Greece
    Immunity 10:387-98. 1999
    ..e., chronic inflammatory arthritis and Crohn's-like inflammatory bowel disease, suggests that defective function of ARE may be etiopathogenic for the development of analogous human pathologies...
  3. pmc TGF-beta-activated kinase 1 signaling maintains intestinal integrity by preventing accumulation of reactive oxygen species in the intestinal epithelium
    Rie Kajino-Sakamoto
    Department of Environmental and Molecular Toxicology, North Carolina State University, Raleigh, NC 27695, USA
    J Immunol 185:4729-37. 2010
    ..Thus, TAK1 signaling regulates ROS through transcription factor NF-E2-related factor 2, which is important for intestinal epithelial integrity...
  4. pmc Kinase RIP3 is dispensable for normal NF-kappa Bs, signaling by the B-cell and T-cell receptors, tumor necrosis factor receptor 1, and Toll-like receptors 2 and 4
    Kim Newton
    Molecular Oncology Department, Genentech, Inc, South San Francisco, California 94080, USA
    Mol Cell Biol 24:1464-9. 2004
    ..Thus, we can exclude RIP3 as an essential modulator of NF-kappa B signaling downstream of several receptor systems...
  5. ncbi The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses
    David L Boone
    Department of Medicine, University of California at San Francisco, San Francisco, California 94143 0451, USA
    Nat Immunol 5:1052-60. 2004
    ..The critical function of this deubiquitinating enzyme in the restriction of TLR signals emphasizes the importance of the regulation of ubiquitin conjugation in innate immune cells...
  6. pmc Deletion of tumor necrosis factor-alpha receptor 1 (TNFR1) protects against diet-induced obesity by means of increased thermogenesis
    Talita Romanatto
    Laboratory of Cell Signaling, University of Campinas, 13084 761 São Paulo, Brazil
    J Biol Chem 284:36213-22. 2009
    ..Here, we show that TNFR1 knock-out (TNFR1 KO) mice are protected from diet-induced obesity due to increased thermogenesis...
  7. ncbi Tumor necrosis factor (TNF) ligand and TNF receptor deficiency affects sleep and the sleep EEG
    Tom Deboer
    Institute of Pharmacology and Toxicology, CH 8057, Switzerland
    J Neurophysiol 88:839-46. 2002
    ..Recently, it was shown that TNF receptor 1 (TNFR1) knockout mice (R1KO) sleep less during the light period than controls...
  8. pmc The caspase-cleaved form of LYN mediates a psoriasis-like inflammatory syndrome in mice
    Sandrine Marchetti
    INSERM, U895, Centre Méditerranéen de Médecine Moléculaire C3M, Team 2, Nice, France
    EMBO J 28:2449-60. 2009
    ..Our data identify a new role for Lyn as a regulator of psoriasis through its cleavage by caspases...
  9. pmc Tumor necrosis factor restricts hematopoietic stem cell activity in mice: involvement of two distinct receptors
    Cornelis J H Pronk
    Hematopoietic Stem Cell Laboratory, Lund Strategic Research Center for Stem Cell Biology and Cell Therapy, Lund University, 221 84 Lund, Sweden
    J Exp Med 208:1563-70. 2011
    ..These effects of TNF involve two distinct TNF receptors...
  10. doi TNF-α/Fas-RIP-1-induced cell death signaling separates murine hematopoietic stem cells/progenitors into 2 distinct populations
    Yechen Xiao
    Oncology Institute, Cardinal Bernardin Cancer Center, Loyola University Medical Center, Maywood, IL 60153, USA
    Blood 118:6057-67. 2011
    ..We found that complete inactivation of TNF-α signaling by deleting both of its receptors, 1 and 2 (Tnfr1(-/-)r2(-/-)), can prevent the death of 30% to 40% of Tak1(-/-) HSPCs and partially repress the bone marrow failure ..
  11. pmc Cloning and expression of cDNAs for two distinct murine tumor necrosis factor receptors demonstrate one receptor is species specific
    M Lewis
    Department of Molecular Biology, Genentech, Inc, South San Francisco, CA 94080
    Proc Natl Acad Sci U S A 88:2830-4. 1991
    ..This result suggests that the various activities of human tumor necrosis factor alpha reported in mice or in murine cell lines are probably mediated by mTNF-R1...
  12. ncbi Tumor necrosis factor (TNF) is a physiologic regulator of hematopoietic progenitor cells: increase of early hematopoietic progenitor cells in TNF receptor p55-deficient mice in vivo and potent inhibition of progenitor cell proliferation by TNF alpha in vi
    Y Zhang
    Department of Pharmacology, School of Medicine, Kanazawa University, Japan
    Blood 86:2930-7. 1995
    ..number of Lin-Sca-1+c-kit+ HSCs in bone marrow was significantly increased in tumor necrosis factor (TNF) receptor p55-deficient (TNF-R55-1-) mice compared with the TNF-R55+/+ wild-type mice without a marked change in bone marrow ..
  13. pmc RelB is required for Peyer's patch development: differential regulation of p52-RelB by lymphotoxin and TNF
    Z Buket Yilmaz
    Forschungszentrum Karlsruhe, Institute of Toxicology and Genetics, D 76021 Karlsruhe, Germany
    EMBO J 22:121-30. 2003
    ..Our data indicate an important role of p52-RelB heterodimers in lymphoid organ development downstream of LTbetaR, NIK and IKKalpha...
  14. pmc Tumor necrosis factor receptor 1-mediated signaling is required for skin cancer development induced by NF-kappaB inhibition
    Maria H Lind
    Department of Bioscience, Clinical Research Center, Karolinska Institutet, Novum, SE 141 57 Huddinge, Sweden
    Proc Natl Acad Sci U S A 101:4972-7. 2004
    ..We now show that by crossing K5-IkappaBalpha mice onto a tumor necrosis factor receptor 1(Tnfr1)-null background, both the inflammatory and the tumorigenic responses are blocked...
  15. pmc Blocking TNF-alpha in mice reduces colorectal carcinogenesis associated with chronic colitis
    Boryana K Popivanova
    Division of Molecular Bioregulation, Cancer Research Institute, Kanazawa University, Kanazawa, Japan
    J Clin Invest 118:560-70. 2008
    ..AOM and DSS increased TNF-alpha expression and the number of infiltrating leukocytes expressing its major receptor, p55 (TNF-Rp55), in the lamina propria and submucosal regions of the colon...
  16. pmc TNF receptor I sensitizes neurons to erythropoietin- and VEGF-mediated neuroprotection after ischemic and excitotoxic injury
    Era Taoufik
    Laboratory of Molecular Genetics, Hellenic Pasteur Institute, 11521 Athens, Greece
    Proc Natl Acad Sci U S A 105:6185-90. 2008
    ..receptor (TNFR)I mediates neuroprotection by comparing the gene expression profiles of lesioned cortex from WT and TNFRI KO mice after permanent middle cerebral artery occlusion...
  17. pmc Concerted action of wild-type and mutant TNF receptors enhances inflammation in TNF receptor 1-associated periodic fever syndrome
    Anna Simon
    Inflammatory Biology Section, Laboratory of Clinical Investigation and Immunoregulation Section, Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 107:9801-6. 2010
    TNF, acting through p55 tumor necrosis factor receptor 1 (TNFR1), contributes to the pathogenesis of many inflammatory diseases...
  18. pmc Colitogenic role of tumour necrosis factor (TNF) receptors in trinitrobenzene sulphonic acid colitis: TNF-R1 ablation does not affect systemic inflammatory response
    Y Yang
    Department of Molecular Immunology, Institute of Basic Medical Sciences, Beijing, China
    Clin Exp Immunol 165:372-82. 2011
    ..These findings suggest that either TNF-R1 or TNF-R2 plays a pathogenic role in the pathology of colitis and TNF signalling via TNF-R1 or TNF-R2 alone is not sufficient for inducing mucosal damage...
  19. pmc Disrupted sleep without sleep curtailment induces sleepiness and cognitive dysfunction via the tumor necrosis factor-α pathway
    Vijay Ramesh
    Section of Sleep Medicine, Department of Pediatrics, Pritzker School of Medicine, The University of Chicago, Chicago, IL, USA
    J Neuroinflammation 9:91. 2012
    ..The aim of this study was to examine role of the TNF-α pathway after long-term sleep fragmentation in mice...
  20. pmc TNFR1-activated reactive oxidative species signals up-regulate osteogenic Msx2 programs in aortic myofibroblasts
    Chung Fang Lai
    Department of Internal Medicine, Washington University in St Louis, Missouri 63110, USA
    Endocrinology 153:3897-910. 2012
    ..Aortic myofibroblasts from TNFR1(-/-) mice expressed levels of Msx2 that were 5% that of wild-type and were not inducible by TNF...
  21. pmc Requirement for the NF-kappaB family member RelA in the development of secondary lymphoid organs
    Elizabeth Alcamo
    Center for Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    J Exp Med 195:233-44. 2002
    ..Analyses of TNFR1/RelA-deficient embryonic tissues and of radiation chimeras suggest that the dependence on RelA is manifest not in ..
  22. pmc Crucial role of tumor necrosis factor receptor 1 expression on nonhematopoietic cells for B cell localization within the splenic white pulp
    M Tkachuk
    Molecular Immunology, Swiss Tropical Institute, Basel, CH 4002, Switzerland
    J Exp Med 187:469-77. 1998
    ..Here we report that in tumor necrosis factor receptor 1-deficient mice (TNFR1(-/-)), the location of B cells was altered and that plasma cells were ..
  23. pmc Requirement for membrane lymphotoxin in natural killer cell development
    K Iizuka
    Departments of Internal Medicine and Pathology, Howard Hughes Medical Institute, and Center for Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 96:6336-40. 1999
    ..They also support a cellular and molecular mechanism by which NK cell precursors themselves deliver essential signals, through the membrane ligand, that induce the microenvironment to promote further NK cell and NK/T cell development...
  24. ncbi Tumor necrosis factor receptor 1 and 2 proteins are differentially regulated during Wallerian degeneration of mouse sciatic nerve
    Annette George
    Neurologische Klinik der Universität, Josef Schneider Str 11, 97080 Wurzburg, Germany
    Exp Neurol 192:163-6. 2005
    ..Here, we investigated local protein levels of the two known TNF receptors, TNF receptor 1 and 2 (TNFR1, TNFR2), on days 0, 1, 3, 7, 14, and 28 after unilateral crush or chronic constriction injury (CCI) of mouse ..
  25. pmc Oligodendrocyte apoptosis and primary demyelination induced by local TNF/p55TNF receptor signaling in the central nervous system of transgenic mice: models for multiple sclerosis with primary oligodendrogliopathy
    K Akassoglou
    Department of Molecular Genetics, Hellenic Pasteur Institute, Athens, Greece
    Am J Pathol 153:801-13. 1998
    ..we have analyzed disease pathology in central nervous system-expressing TNF transgenic mice, with or without p55 or p75TNF receptors, using combined in situ terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick-end ..
  26. ncbi Differential requirements by CD4+ and CD8+ T cells for soluble and membrane TNF in control of Francisella tularensis live vaccine strain intramacrophage growth
    Siobhán C Cowley
    Laboratory of Mycobacterial Diseases and Cellular Immunology, Center for Biologics Research and Evaluation, US Food and Drug Administration, Rockville, MD 20852, USA
    J Immunol 179:7709-19. 2007
    ....
  27. ncbi High sensitivity of transgenic mice expressing soluble TNFR1 fusion protein to mycobacterial infections: synergistic action of TNF and IFN-gamma in the differentiation of protective granulomas
    I Garcia
    Department of Pathology, C M U, Geneva, Switzerland
    Eur J Immunol 27:3182-90. 1997
    ....
  28. ncbi Upregulation of the p75 but not the p55 TNF-alpha receptor mRNA after silica and bleomycin exposure and protection from lung injury in double receptor knockout mice
    L A Ortiz
    Section of Pulmonary Diseases, Critical Care and Environmental Medicine, Section of Endocrinology, Tulane University Medical Center, New Orleans, Louisiana, USA
    Am J Respir Cell Mol Biol 20:825-33. 1999
    We have investigated a potential role for tumor necrosis factor (TNF)-alpha and its two receptors (p55 and p75) in lung injury. We used several varieties of mice exposed endotracheally to two fibrogenic agents, silica (0...
  29. ncbi The role of tumor necrosis factor-alpha in liver toxicity, inflammation, and fibrosis induced by carbon tetrachloride
    P P Simeonova
    Toxicology and Molecular Biology Branch, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, West Virginia 26505, USA
    Toxicol Appl Pharmacol 177:112-20. 2001
    ..This response was associated primarily with type-1 (TNFR1) rather than type-2 (TNFR2) receptor responses...
  30. pmc The death domain kinase RIP protects thymocytes from tumor necrosis factor receptor type 2-induced cell death
    Nicole Cusson
    Department of Molecular Genetics and Microbiology, Program in Immunology Virology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    J Exp Med 196:15-26. 2002
    ..The death domain kinase, receptor interacting protein (rip), is recruited to the TNFR1 upon receptor activation...
  31. ncbi Exaggerated hepatotoxicity of acetaminophen in mice lacking tumor necrosis factor receptor-1. Potential role of inflammatory mediators
    Carol R Gardner
    Environmental and Occupational Health Sciences Institute, Rutgers University and University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, NJ 08854 8020, USA
    Toxicol Appl Pharmacol 192:119-30. 2003
    Transgenic mice with a targeted disruption of the tumor necrosis factor receptor 1 (TNFR1) gene were used to analyze the role of TNF-alpha in pro- and anti-inflammatory mediator production and liver injury induced by acetaminophen...
  32. ncbi Differential role of tumor necrosis factor receptors in mouse brain inflammatory responses in cryolesion brain injury
    Albert Quintana
    Institute of Neurosciences and Department of Cellular Biology, Physiology and Immunology, Animal Physiology Unit, Faculty of Sciences, Autonomous University of Barcelona, Bellaterra, Barcelona, Spain
    J Neurosci Res 82:701-16. 2005
    ..This cytokine exerts its functions via interaction with two receptors: type-1 receptor (TNFR1) and type-2 receptor (TNFR2)...
  33. ncbi The cytokine TNFalpha increases the proportion of DRG neurones expressing the TRPV1 receptor via the TNFR1 receptor and ERK activation
    Susanne Hensellek
    Institute of Physiology I, Friedrich Schiller University of Jena, Teichgraben 8, D 07740 Jena, Germany
    Mol Cell Neurosci 36:381-91. 2007
    ..This TNFalpha effect was abolished in mice DRG neurones when DRG cultures were obtained from tnfr1/2-/- and tnfr1-/-, but not from tnfr2-/- mice...
  34. pmc Role of astrocytes and chemokine systems in acute TNFalpha induced demyelinating syndrome: CCR2-dependent signals promote astrocyte activation and survival via NF-kappaB and Akt
    Marlon P Quinones
    South Texas Veterans Health Care System, Audie L Murphy Division, San Antonio, TX, USA
    Mol Cell Neurosci 37:96-109. 2008
    ..Collectively, our data suggests that transgenic murine models of MS are useful to dissect mechanisms of disease and that in these models, up-regulation of chemokines and their receptors may be key determinants in TID...
  35. doi Endogenous tumor necrosis factor alpha (TNFalpha) requires TNF receptor type 2 to generate heat hyperalgesia in a mouse cancer model
    Cristina E Constantin
    Division of Physiology, Department of Physiology and Medical Physics, Innsbruck Medical University, 6020 Innsbruck, Austria
    J Neurosci 28:5072-81. 2008
    ..type 2 (TNFR2) gene attenuated heat hyperalgesia and prevented TRPV1 upregulation in tumor-bearing mice, whereas TNFR1 gene deletion played a minor role...
  36. ncbi Role of lymphotoxin and the type I TNF receptor in the formation of germinal centers
    M Matsumoto
    Center for Immunology and Howard Hughes Medical Institute, Washington University School of Medicine, St Louis, MO 63110, USA
    Science 271:1289-91. 1996
    ..Germinal center formation was restored in LT-alpha-deficient mice by transplantation of normal bone marrow, indicating that the LT-alpha-expressing cells required to establish this lymphoid structure are derived from bone marrow...
  37. ncbi Altered neuronal and microglial responses to excitotoxic and ischemic brain injury in mice lacking TNF receptors
    A J Bruce
    Sanders Brown Research Center on Aging, University of Kentucky, Lexington 40536 0230, USA
    Nat Med 2:788-94. 1996
    ..Drugs that target TNF signaling pathways may prove beneficial in treating stroke and traumatic brain injury...
  38. ncbi Attenuation of collagen-induced arthritis in 55-kDa TNF receptor type 1 (TNFR1)-IgG1-treated and TNFR1-deficient mice
    L Mori
    Department of Research, University Hospital, Basel, Switzerland
    J Immunol 157:3178-82. 1996
    The role of TNF and its type 1 receptor (TNFR1) in the pathogenesis of collagen-induced arthritis (CIA) was investigated in mice using two approaches...
  39. ncbi Accelerated atherosclerosis in mice lacking tumor necrosis factor receptor p55
    S A Schreyer
    Department of Medicine, University of Washington, Seattle, Washington 98195, USA
    J Biol Chem 271:26174-8. 1996
    ..There are two receptors known to elicit TNF responses, termed p55 and p75...
  40. pmc Independent signals regulate development of primary and secondary follicle structure in spleen and mesenteric lymph node
    Y X Fu
    Division of Laboratory Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 94:5739-43. 1997
    ..These data demonstrate that the signals that regulate the development of distinct T and B cell zones as well as the signals that regulate B cell activation to produce clusters of PNA+ cells differ between the spleen and LNs...
  41. ncbi Crucial role of tumor necrosis factor (TNF) receptor 2 and membrane-bound TNF in experimental cerebral malaria
    R Lucas
    Department of Anesthesiology, Pharmacology and Surgical Intensive Care, University Medical Center, Geneva, Switzerland
    Eur J Immunol 27:1719-25. 1997
    ..A significant increase in the expression of TNF-receptor 2 (TNFR2, p75), but not of TNFR1 (p55), was found on brain microvessels at the time of CM in susceptible animals...
  42. ncbi Crucial role of TNF receptor type 1 (p55), but not of TNF receptor type 2 (p75), in murine toxoplasmosis
    M Deckert-Schlüter
    Institut für Neuropathologie, Universitatskliniken Bonn, Germany
    J Immunol 160:3427-36. 1998
    TNF-alpha exerts its biologic activity through two distinct receptors, TNF receptor type 1 (TNFR1, p55) and TNF receptor type 2 (TNFR2, p75)...
  43. ncbi Differential activities of secreted lymphotoxin-alpha3 and membrane lymphotoxin-alpha1beta2 in lymphotoxin-induced inflammation: critical role of TNF receptor 1 signaling
    R Sacca
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06520, USA
    J Immunol 160:485-91. 1998
    ..Secreted LT alpha3 can bind to two cell surface receptors, TNFR1 and TNFR2, while the membrane-bound heterotrimer LT alpha1beta2 has been shown to interact with a distinct ..
  44. ncbi Decreased resistance of TNF receptor p55- and p75-deficient mice to chronic toxoplasmosis despite normal activation of inducible nitric oxide synthase in vivo
    G S Yap
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institutes of Allergy and Infectious Diseases, Bethesda, MD 20892, USA
    J Immunol 160:1340-5. 1998
    ..in host defense to the intracellular parasite, Toxoplasma gondii, was investigated in mice lacking both the p55 and p75 receptors for this cytokine. Upon i.p...
  45. pmc A critical role of the p75 tumor necrosis factor receptor (p75TNF-R) in organ inflammation independent of TNF, lymphotoxin alpha, or the p55TNF-R
    E Douni
    Department of Molecular Genetics, Hellenic Pasteur Institute, 115 21 Athens, Hellas
    J Exp Med 188:1343-52. 1998
    ..These results establish an independent role for enhanced p75TNF-R production in the pathogenesis of inflammatory disease and implicate the direct involvement of this receptor in a wide range of human inflammatory pathologies...
  46. ncbi Severity of symptoms and demyelination in MOG-induced EAE depends on TNFR1
    H P Eugster
    Department of Internal Medicine, University Hospital, Zurich, Switzerland
    Eur J Immunol 29:626-32. 1999
    The individual role of tumor necrosis factor receptor 1 (TNFR1) and TNFR2 signaling in experimental autoimmune encephalomeylitis (EAE) was investigated using mice lacking TNFR1 (TNFR1-/-), TNFR2 (TNFR2-/-) as well as double receptor (..
  47. pmc Absence of tumor necrosis factor rescues RelA-deficient mice from embryonic lethality
    T S Doi
    Laboratory of Immunology, Aichi Cancer Center Research Institute, Nagoya 464, Japan
    Proc Natl Acad Sci U S A 96:2994-9. 1999
    ..Thus, the RelA-mediated antiapoptotic signal that protects normal cells from TNF injury in vitro can be shown to be operative in vivo...
  48. ncbi Autoimmune intestinal pathology induced by hsp60-specific CD8 T cells
    U Steinhoff
    Department of Immunology, Max Planck Institute of Infection Biology, Germany
    Immunity 11:349-58. 1999
    ..This report demonstrates that CD8 T cells with defined antigen specificity cause intestinal inflammation, emphasizing a link between infection and autoimmune disease...
  49. ncbi Tumor necrosis factor and the p55TNF receptor are required for optimal development of the marginal sinus and for migration of follicular dendritic cell precursors into splenic follicles
    M Pasparakis
    Laboratory of Molecular Genetics, Hellenic Pasteur Institute, Athens, 115 21, Greece
    Cell Immunol 201:33-41. 2000
    ....
  50. ncbi IKKbeta is essential for protecting T cells from TNFalpha-induced apoptosis
    U Senftleben
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, University of California San Diego, La Jolla, CA 92093, USA
    Immunity 14:217-30. 2001
    ..Indeed, Ikkbeta-/- radiation chimeras exibit elevated circulating TNFalpha, and Ikkbeta-/- thymocytes display increased TNFalpha sensitivity...
  51. pmc Interleukin-10 targets p38 MAPK to modulate ARE-dependent TNF mRNA translation and limit intestinal pathology
    D Kontoyiannis
    Institute of Immunology, BSRC Alexander Fleming, 166 72 Vari, Greece
    EMBO J 20:3760-70. 2001
    ..This cross-talk is necessary for optimal TNF production and for the maintenance of immune homeostasis in the gut...
  52. ncbi Targeted mutation of TNF receptor I rescues the RelA-deficient mouse and reveals a critical role for NF-kappa B in leukocyte recruitment
    E Alcamo
    Center for Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    J Immunol 167:1592-600. 2001
    ..immunity, we genetically suppressed this embryonic lethality by breeding the RelA deficiency onto a TNFR type 1 (TNFR1)-deficient background...
  53. pmc Genetic dissection of the cellular pathways and signaling mechanisms in modeled tumor necrosis factor-induced Crohn's-like inflammatory bowel disease
    Dimitris Kontoyiannis
    Institute for Immunology, Biomedical Sciences Research Center Al Fleming, Vari 166 72, Greece Division of Gastroenterology and Hepatology, University of Virginia Health Sciences Center, Charlottesville, VA 22906, USA
    J Exp Med 196:1563-74. 2002
    ..Our data establish the existence of redundant cellular pathways operating downstream of TNF in inflammatory bowel disease, and demonstrate the therapeutic potential of selective kinase blockade in TNF-mediated intestinal pathology...
  54. ncbi Paradoxical anti-inflammatory actions of TNF-alpha: inhibition of IL-12 and IL-23 via TNF receptor 1 in macrophages and dendritic cells
    Maria Zakharova
    Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Immunol 175:5024-33. 2005
    ..IL-12p40 production was also inhibited in dendritic cells. TNFR1 was established as the main receptor involved in IL-12p40 regulation, because IL-12p40 levels were not affected by ..
  55. ncbi Urothelial lesion formation is mediated by TNFR1 during neurogenic cystitis
    Michael C Chen
    Departments of Urology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Am J Physiol Renal Physiol 291:F741-9. 2006
    ..In urothelial cultures, only siRNAs targeting TNFR1, but not TNFR2, blocked TNF-induced apoptosis, indicating a primary role for TNFR1...
  56. ncbi TNF-alpha is necessary for induction of coronary artery inflammation and aneurysm formation in an animal model of Kawasaki disease
    Joyce S Hui-Yuen
    Cancer Research Program, The Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto, Ontario, Canada
    J Immunol 176:6294-301. 2006
    ..Mice treated with the TNF-alpha-blocking agent etanercept, as well as TNFRI knockout mice, are resistant to development of both coronary arteritis and coronary aneurysm formation...
  57. pmc TAK1 is a master regulator of epidermal homeostasis involving skin inflammation and apoptosis
    Emily Omori
    Department of Environmental and Molecular Toxicology, North Carolina State University, Raleigh, North Carolina 27695 7633, USA
    J Biol Chem 281:19610-7. 2006
    ..Our results demonstrate that TAK1 is a master regulator of TNF signaling in skin and regulates skin inflammation and keratinocyte death...
  58. pmc Expression of tumor necrosis factor receptor-1 in arterial wall cells promotes atherosclerosis
    Lisheng Zhang
    Departments of Medicine Cardiology, Duke University Medical Center, Durham, NC 27710, USA
    Arterioscler Thromb Vasc Biol 27:1087-94. 2007
    Mechanisms by which tumor necrosis factor-alpha (TNF) contributes to atherosclerosis remain largely obscure. We therefore sought to determine the role of the arterial wall TNF receptor-1 (TNFR1) in atherogenesis.
  59. pmc Mesenchymal cell targeting by TNF as a common pathogenic principle in chronic inflammatory joint and intestinal diseases
    Maria Armaka
    Institute of Immunology, Biomedical Sciences Research Center BSRC Alexander Fleming, Vari 16672, Greece
    J Exp Med 205:331-7. 2008
    ..Bone marrow grafting experiments demonstrated that development of arthritis requires TNF receptor I (TNFRI) expression in the radiation-resistant compartment, which is also known to be a sufficient target of TNF in the ..
  60. doi Soluble TNF-alpha but not transmembrane TNF-alpha sensitizes T cells for enhanced activation-induced cell death
    Stefan Muller
    Institute of Pathology, Division of Experimental Pathology, University of Bern, Bern, Switzerland
    Eur J Immunol 39:3171-80. 2009
    ....
  61. ncbi RIP: a novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death
    B Z Stanger
    Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell 81:513-23. 1995
    ..RIP also interacts weakly with the p55 tumor necrosis factor receptor (TNFR1) intracellular domain, but not with a mutant version of Fas corresponding to the murine lprcg mutation...
  62. ncbi Tumor necrosis factor-alpha is required in the protective immune response against Mycobacterium tuberculosis in mice
    J L Flynn
    Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pennsylvania 15261, USA
    Immunity 2:561-72. 1995
    ..TNF alpha and the 55 kDa TNF receptor are necessary conditions for protection against murine M. tuberculosis infection, but are not solely responsible for the tissue damage observed...
  63. ncbi Induction of apoptosis in mature T cells by tumour necrosis factor
    L Zheng
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 377:348-51. 1995
    ..Our results suggest that autoregulatory apoptosis of the mature T cells can occur by two distinct molecular mechanisms...
  64. pmc Monoclonal antibodies specific for murine p55 and p75 tumor necrosis factor receptors: identification of a novel in vivo role for p75
    K C Sheehan
    Center for Immunology, Washington University School of Medicine, St Louis, Missouri 63110
    J Exp Med 181:607-17. 1995
    Monoclonal antibodies (mAbs) specific for the murine p55 and p75 tumor necrosis factor (TNF) receptors were produced after immunization of Armenian hamsters with the purified soluble extracellular domains of each receptor protein...
  65. ncbi Decreased sensitivity to tumour-necrosis factor but normal T-cell development in TNF receptor-2-deficient mice
    S L Erickson
    Department of Cell Genetics, Genentech, South San Francisco, California 94080
    Nature 372:560-3. 1994
    ..Tumour necrosis factor (TNF) elicits multiple biological effects through two distinct cell surface receptors, TNF-R1 (p55) and TNF-R2 (p75)...
  66. ncbi Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection
    K Pfeffer
    Department of Medical Biophysics, University of Toronto, Princess Margaret Hospital, Canada
    Cell 73:457-67. 1993
    ..activities of tumor necrosis factor (TNF) are mediated by two distinct cell surface receptors of 55 kd (TNFRp55) and 75 kd (TNFRp75). Using gene targeting, we generated a TNFRp55-deficient mouse strain...
  67. pmc Differentiation of follicular dendritic cells and full antibody responses require tumor necrosis factor receptor-1 signaling
    M Le Hir
    Swiss Institute of Technology, Institute of Toxicology, Schwerzenbach, Switzerland
    J Exp Med 183:2367-72. 1996
    ..Spleen morphology and antibody response were investigated in wild-type, TNFR1-/-, TNFR2-/- and TNF/LT alpha-/- mice immunized with SRBC...
  68. pmc Defective Peyer's patch organogenesis in mice lacking the 55-kD receptor for tumor necrosis factor
    B Neumann
    Institute for Medical Microbiology and Hygiene, Technical University of Munich, Germany
    J Exp Med 184:259-64. 1996
    Lymphotoxin alpha (LT-alpha) may form secreted homotrimers binding to p55 and p75 tumor necrosis factor (TNF) receptors or cell surface-bound heterotrimers with LT-beta that interact with the LT-beta receptor...
  69. ncbi TNF receptors in murine Candida albicans infection: evidence for an important role of TNF receptor p55 in antifungal defense
    S Steinshamn
    Institute of Cancer Research and Molecular Biology, University Medical Center, Trondheim, Norway
    J Immunol 157:2155-9. 1996
    TNF mediates multiple biologic activities through two distinct cell surface receptors, TNFR-p55 and TNFR-p75. TNF plays an important role in nonspecific resistance against the fungus Candida albicans...
  70. pmc Initiation of liver growth by tumor necrosis factor: deficient liver regeneration in mice lacking type I tumor necrosis factor receptor
    Y Yamada
    Department of Pathology, University of Washington, Seattle 98195, USA
    Proc Natl Acad Sci U S A 94:1441-6. 1997
    ..The results indicate that TNF, signaling through the TNFR-I, can initiate liver regeneration and acts by activating an interleukin 6-dependent pathway that involves the STAT3 transcription factor...
  71. ncbi Ligand-induced formation of p55 and p75 tumor necrosis factor receptor heterocomplexes on intact cells
    J K Pinckard
    Department of Pathology, Center for Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 272:10784-9. 1997
    The p55 and p75 tumor necrosis factor receptors are known to mediate their effects on cells through distinct signaling pathways...
  72. ncbi TNF receptor p55 controls early acute graft-versus-host disease
    D E Speiser
    Ontario Cancer Institute, Department of Medical Biophysics, University of Toronto, Canada
    J Immunol 158:5185-90. 1997
    ..To understand the effector mechanisms of GVHD, we investigated the role of the TNF receptor p55 (TNFRp55), which is known to be important in inflammation and cytotoxicity...
  73. ncbi A murine transmembrane tumor necrosis factor (TNF) transgene induces arthritis by cooperative p55/p75 TNF receptor signaling
    L Alexopoulou
    Department of Molecular Genetics, Hellenic Pasteur Institute, Athens, Greece
    Eur J Immunol 27:2588-92. 1997
    ..transmembrane from of the murine TNF protein (muTNF delta 1-12) which is known to utilize efficiently both the p55 and the p75TNFR...
  74. ncbi TNF receptor type 2 mediates thymocyte proliferation independently of TNF receptor type 1
    M Grell
    Institute of Cell Biology and Immunology, University of Stuttgart, Germany
    Eur J Immunol 28:257-63. 1998
    ....
  75. ncbi TNF receptor-deficient mice reveal divergent roles for p55 and p75 in several models of inflammation
    J J Peschon
    Department of Molecular Immunology, Immunex Corp, Seattle, WA 98101, USA
    J Immunol 160:943-52. 1998
    ..potent proinflammatory cytokine TNF are mediated by two structurally related, but functionally distinct, receptors, p55 and p75, that are coexpressed on most cell types...
  76. ncbi The lymphotoxin beta receptor controls organogenesis and affinity maturation in peripheral lymphoid tissues
    A Fütterer
    Institute of Medical Microbiology, Immunology, and Hygiene, Technical University of Munich, Germany
    Immunity 9:59-70. 1998
    ..Peanut agglutinin+ cells were aberrantly detectable around central arterioles. In contrast to TNF receptor p55-/- mice, antibody affinity maturation was impaired...
  77. pmc Complementation of lymphotoxin alpha knockout mice with tumor necrosis factor-expressing transgenes rectifies defective splenic structure and function
    L Alexopoulou
    Department of Molecular Genetics, Hellenic Pasteur Institute, 115 21 Athens, Greece
    J Exp Med 188:745-54. 1998
    ..of LTbeta-deficient mice, complementation of LTalpha knockout mice with TNF-expressing transgenes leads to a p55 TNF receptor-dependent restoration of B/T cell zone segregation and a partial preservation of primary B cell ..
  78. ncbi Analysis of liver regeneration in mice lacking type 1 or type 2 tumor necrosis factor receptor: requirement for type 1 but not type 2 receptor
    Y Yamada
    Department of Pathology, University of Washington School of Medicine, Seattle, WA 98195 7705, USA
    Hepatology 28:959-70. 1998
    ..Inhibition of AP-1 and C/EBP binding and in the expression of c-jun and c-myc mRNA in the first 4 hours after PH, as well as the apparent lack of Fos in AP-1 complexes, had no effect on the timing or extent of DNA replication...
  79. ncbi Involvement of distinct cellular compartments in the abnormal lymphoid organogenesis in lymphotoxin-alpha-deficient mice and alymphoplasia (aly) mice defined by the chimeric analysis
    M Matsumoto
    First Department of Internal Medicine, School of Medicine, Ehime University, Japan
    J Immunol 163:1584-91. 1999
    ....
  80. pmc Tumor necrosis factor receptor p55-deficient mice respond to acute Yersinia enterocolitica infection with less apoptosis and more effective host resistance
    Y X Zhao
    Division of Rheumatology, Toronto Western Hospital, University of Toronto, Toronto, Canada
    Infect Immun 68:1243-51. 2000
    ..phase of infection by Yersinia enterocolitica by using mice rendered genetically deficient in TNF receptor p55 (TNFRp55(-/-))...
  81. ncbi Lethal granuloma disintegration in mycobacteria-infected TNFRp55-/- mice is dependent on T cells and IL-12
    S Ehlers
    Division of Molecular Infection Biology, Research Center Borstel, Germany
    J Immunol 165:483-92. 2000
    Genetically susceptible, TNFRp55 gene-deficient (TNFRp55-/-) mice succumb to infection with Mycobacterium avium. Before their death, M...
  82. ncbi Tumor necrosis factor receptor 2 plays a minor role for mycobacterial immunity
    M Jacobs
    Department of Immunology, University of Cape Town, South Africa
    Pathobiology 68:68-75. 2000
    ..Therefore, anti-mycobacterial immunity is largely dependent on TNF signalling via the TNF-R1, while activation of TNF-R2 plays a minor role...
  83. ncbi TNF regulates thymocyte production by apoptosis and proliferation of the triple negative (CD3-CD4-CD8-) subset
    J G Baseta
    Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Immunol 165:5621-30. 2000
    ..TNF apoptosis affected only the TN3 (CD44(-)CD25(+)) and TN4 (CD44(-)CD25(-)) subsets that expressed both TNFR-p55 and -p75...
  84. ncbi Divergent roles for p55 and p75 tumor necrosis factor receptors in the pathogenesis of MOG(35-55)-induced experimental autoimmune encephalomyelitis
    G C Suvannavejh
    Department of Microbiology Immunology, Interdepartmental Immunology Center, Northwestern University Medical School, 303 E Chicago Avenue, Illinois 60611, USA
    Cell Immunol 205:24-33. 2000
    ..role in the apoptotic elimination of autoreactive effector cells, we assessed the roles of the p55 (TNFR1/Tnfrsf1a/CD120a) and p75 (TNFR2/Tnfrsf1b/CD120b) TNF receptors in the pathogenesis of MOG(35-55)-induced experimental ..
  85. pmc Impaired preneoplastic changes and liver tumor formation in tumor necrosis factor receptor type 1 knockout mice
    B Knight
    University of Western Australia, Department of Biochemistry, Nedlands WA 6907, Australia
    J Exp Med 192:1809-18. 2000
    ..The TNF inflammatory pathway may be a target for therapeutic intervention during the early stages of liver carcinogenesis...
  86. ncbi Collagen-induced arthritis in TNF receptor-1-deficient mice: TNF receptor-2 can modulate arthritis in the absence of TNF receptor-1
    Y Tada
    Department of Internal Medicine, Saga Medical School, Saga, 849 8501, Japan
    Clin Immunol 99:325-33. 2001
    ..We have investigated the roles of TNF receptor-1 (TNFR1) and TNF receptor-2 (TNFR2) in collagen-induced arthritis (CIA) by inducing CIA in mice genetically deficient in ..
  87. pmc Lymph nodal prion replication and neuroinvasion in mice devoid of follicular dendritic cells
    Marco Prinz
    Institute of Neuropathology, University Hospital of Zurich, Schmelzbergstrasse 12, CH 8091 Zurich, Switzerland
    Proc Natl Acad Sci U S A 99:919-24. 2002
    ..However, TNFR1(-/-), TNFR2(-/-), and some TNFalpha(-/-) mice developed scrapie similarly to wild-type mice...
  88. pmc NF-kappaB RelA opposes epidermal proliferation driven by TNFR1 and JNK
    Jennifer Y Zhang
    VA Palo Alto Healthcare System, Palo Alto, California 94305, USA
    Genes Dev 18:17-22. 2004
    ..Hyperproliferation is TNFR1-dependent because Tnfr1 deletion normalized cell division...
  89. ncbi Two tumour necrosis factor receptors: structure and function
    P Vandenabeele
    Laboratory of Molecular Biology, Gent University and VIB, K L Ledeganckstraat 35, B 9000 Gent, Belgium
    Trends Cell Biol 5:392-9. 1995
    ..Recent research suggests that several TNF-R-associated proteins, including kinases, may initiate cytoplasmic signal transduction...
  90. ncbi Tumor necrosis factor receptors 1 and 2 differentially regulate survival, cardiac dysfunction, and remodeling in transgenic mice with tumor necrosis factor-alpha-induced cardiomyopathy
    Yoshihiro Higuchi
    Center for Translational Medicine, Department of Medicine, Jefferson Medical College, Philadelphia 19107, USA
    Circulation 109:1892-7. 2004
    Tumor necrosis factor (TNF)-alpha plays a pathophysiological role in heart failure. Although both TNF receptor 1 (TNFR1) and 2 (TNFR2) are present in the heart, comparatively little is known about the role of TNFR2.
  91. pmc Tumor necrosis factor (TNF) receptor shedding controls thresholds of innate immune activation that balance opposing TNF functions in infectious and inflammatory diseases
    Sofia Xanthoulea
    Institute of Immunology, Biomedical Sciences Research Centre Al Fleming, 34 Al Fleming St, Vari 166 72, Greece
    J Exp Med 200:367-76. 2004
    ..Assessment of p55TNFR shedding may thus be of prognostic value in infectious, inflammatory, and autoimmune diseases...
  92. ncbi I kappa B kinase complex alpha kinase activity controls chemokine and high endothelial venule gene expression in lymph nodes and nasal-associated lymphoid tissue
    Danielle L Drayton
    Department of Epidemiology and Public Health, Section of Immunobiology, Yale University School of Medicine, 60 College Street, New Haven, CT 06520, USA
    J Immunol 173:6161-8. 2004
    ..In this study, analysis of LTbeta(-/-) mice identifies GlyCAM-1 as another LTbeta-dependent gene. In contrast, TNFRI(-/-) mice, which lose classical NF-kappaB pathway activity but retain alternative NF-kappaB pathway activity, ..
  93. pmc Renal cell-expressed TNF receptor 2, not receptor 1, is essential for the development of glomerulonephritis
    Volker Vielhauer
    Center of Excellence in Vascular Biology, Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 115:1199-209. 2005
    ..proinflammatory and immunosuppressive properties that may segregate at the level of the 2 TNF receptors (TNFRs), TNFR1 and TNFR2...
  94. ncbi Tissue inhibitor of metalloproteinase 3 regulates TNF-dependent systemic inflammation
    David S Smookler
    Ontario Cancer Institute, University Health Network, Toronto, Canada
    J Immunol 176:721-5. 2006
    ..Ablation of the TNF receptor gene p55 (Tnfrsf1a) or treatment with a synthetic metalloproteinase inhibitor rescues timp3-/- mice...
  95. ncbi FDC-specific functions of p55TNFR and IKK2 in the development of FDC networks and of antibody responses
    Panayiotis Victoratos
    Institute of Immunology, Biomedical Sciences Research Center Al Fleming, Vari 166 72, Greece
    Immunity 24:65-77. 2006
    ....
  96. pmc Abnormal disulfide-linked oligomerization results in ER retention and altered signaling by TNFR1 mutants in TNFR1-associated periodic fever syndrome (TRAPS)
    Adrian A Lobito
    Immunoregulation Unit, Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda MD 20892, USA
    Blood 108:1320-7. 2006
    ..an autosomal dominant systemic autoinflammatory disease associated with heterozygous mutations in TNF receptor 1 (TNFR1)...
  97. ncbi Deficiency of TNFR1 protects myocardium through SOCS3 and IL-6 but not p38 MAPK or IL-1beta
    Meijing Wang
    Departments of Surgery, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Am J Physiol Heart Circ Physiol 292:H1694-9. 2007
    ..via STAT3/SOCS3 signaling in the heart and, if so, whether this effect is through the type 1 55-kDa TNF receptor (TNFR1)...
  98. ncbi Epithelial NEMO links innate immunity to chronic intestinal inflammation
    Arianna Nenci
    Institute for Genetics, University of Cologne, Zulpicher Strasse 47, 50674 Cologne, Germany
    Nature 446:557-61. 2007
    ....
  99. ncbi Tumor necrosis factor-alpha is toxic via receptor 1 and protective via receptor 2 in a murine model of myocardial infarction
    Yoshiya Monden
    Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, 3 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Am J Physiol Heart Circ Physiol 293:H743-53. 2007
    ..TNF-alpha initiates its biological effects by binding two distinct receptors: R1 (p55) and R2 (p75)...
  100. pmc TNF-alpha is critical for antitumor but not antiviral T cell immunity in mice
    Thomas Calzascia
    The Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, Toronto, Ontario, Canada
    J Clin Invest 117:3833-45. 2007
    ..Here, we show a role for TNF-alpha and its receptors, TNFR1 and TNFR2, specifically in antitumor immunity...
  101. doi TNF receptor type I-dependent activation of innate responses to reduce intestinal damage-associated mortality
    Emiko Mizoguchi
    Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Gastroenterology 134:470-80. 2008
    ..However, it remains unclear which cell types activated through TNFR-associated signaling cascades are involved in the pathogenesis of colitis...

Research Grants44

  1. Enhancement of CD8 T Cell Immunity by IL-7 Therapy
    Marulasiddappa Suresh; Fiscal Year: 2008
    ..The proposed studies should aid in the rational design of vaccines that can engender potent CDS T cell memory and protect against poxvirus and arenaviral infections. [unreadable] [unreadable] [unreadable]..
  2. Transport of neurotrophic cytokines after spinal cord injury
    Weihong Pan; Fiscal Year: 2007
    ..Understanding the mechanisms of cytokine transport at this regulatory interface would help in the design of new approaches to treat SCI. ..
  3. Transport of TNFalpha across the BBB
    Weihong Pan; Fiscal Year: 2008
    ..To identify the roles of p55- and p75-receptors, we will study TNFa transport in the presence of receptor antibodies and in the receptor ..
  4. 2008 Biology of Acute Respiratory Infections Gordon Research Conference
    JOSEPH MIZGERD; Fiscal Year: 2007
    ..End of Abstract) [unreadable] [unreadable] [unreadable]..
  5. TNFR ASSOCIATED FACTOR IN PULMONARY RESPONSE TO TNF-A
    Gloria Pryhuber; Fiscal Year: 2003
    ..The proposed studies will demonstrate the cellular function of TRAF1 in vitro and the role of TRAF1 expression in vivo in transgenic overexpression and ablation models stressed by hyperoxia. ..
  6. Cell Specific Responses to TNF-alpha in Lung Fibrosis
    Gloria Pryhuber; Fiscal Year: 2009
    ..This proposal will determine the role of TNFRI/II expression in cells of parenchymal versus hematopoietic origin in the lung response to crystalline silica, ..
  7. Direct Regulation of CD8 T Cells by Interferon gamma
    Marulasiddappa Suresh; Fiscal Year: 2010
    ..These studies should aid in the development of vaccines against arena viruses in particular and other viruses in general. ..
  8. T cell Function in Murine Model of Multiple Sclerosis
    Moses Rodriguez; Fiscal Year: 2010
    ..The findings are expected to provide new insights into the pathogenesis of axonal and neuronal injury in demyelinating disorders such as multiple sclerosis. ..
  9. Proteomic Analysis of Retinal Ganglion Cell Death in Glaucoma
    GULGUN TEZEL; Fiscal Year: 2010
    ..These studies are expected to provide comprehensive information about the nerve cell death process, thereby allowing new treatment possibilities for 3 million Americans suffering from glaucoma. ..
  10. KUPFFER CELLS AND CHEMICAL TOXICITY
    Debra Laskin; Fiscal Year: 2009
    ..Mechanistic insights derived from these studies may suggest new therapeutic approaches in the treatment of acute liver injury induced by acetaminophen. ..
  11. T reg Cells in Myocarditis
    Sally A Huber; Fiscal Year: 2010
    ..Determine whether the T reg cells are antigen specific (virus), cardiovascular specific (autoimmunity), or non-antigen specific. ..
  12. STUDIES OF LUNG DISEASES OF HIV TRANSGENIC MICE
    Paul Jolicoeur; Fiscal Year: 2009
    ..This research is especially relevant to public health, especially children with AIDS, developing lung diseases at high frequency. ..
  13. TNF Receptors of Colonic Epithelial Cells in IBD
    Emiko Mizoguchi; Fiscal Year: 2007
    ..induces multiple physiological effects through distinct signaling cascades associated with TNF receptor-type I (TNFR1) and -type II (TNFR2)...
  14. Progenitor cell pretreatment against acute surgical I/R
    Daniel Meldrum; Fiscal Year: 2008
    ..abstract_text> ..
  15. Induction of immunological paralysis by CpG DNA
    Ae Kyung Yi; Fiscal Year: 2008
    ..abstract_text> ..
  16. Sex in Myocarditis
    Sally Huber; Fiscal Year: 2008
    ..By understanding the factors controlling virus infection and induction of innate immunity, better mechanism for controlling viral disease should be possible. ..
  17. TNRF1 Signaling Resistance in Ischemic Human Female Myocardium
    Daniel R Meldrum; Fiscal Year: 2010
    ..appreciation that TNF itself may have beneficial or detrimental effects depending on which of its receptors (TNFR1 or TNFR2) is activated...
  18. Novel Mouse Model to Dissect Alzheimer's Disease Pathophysiology
    William Bowers; Fiscal Year: 2008
    ..abstract_text> ..
  19. Regulatory Role of TNFR1 in Inflammatory Bowel Disease
    Emiko Mizoguchi; Fiscal Year: 2007
    ..We have previously identified that tumor necrosis factor receptor -type I (TNFR1) and -type II (TNFR2) are expressed by CEC: TNFR1 is constitutively expressed whereas TNFR2 expression is induced ..
  20. TUMOR NECROSIS FACTOR INVOLVEMENT IN FUMONISIN TOXICITY
    RAGHUBIR SHARMA; Fiscal Year: 2001
    ..Results will help in defining the mechanism(s) of fumonisin toxicity, causes of species-specificity, and provide a better appraisal of risk in humans, including modification of fumonisin response by gram-negative infections. ..
  21. Sex in Viral Myocarditis
    Sally Huber; Fiscal Year: 2004
    ..These studies may provide new insights as to how viruses affect developing host defense responses and how hormones can modulate this initial response. ..
  22. CARDIAC LESIONS IN HIV1 TRANSGENIC MICE
    Paul Jolicoeur; Fiscal Year: 2001
    ..End of Abstract) ..
  23. ENDOTOXIN AND SUSCEPTIBILITY TO TRICHOTHECENE MYCOTOXINS
    James Pestka; Fiscal Year: 2002
    ..Over the long term, this research will provide insight into adverse immunologic consequences that may occur in LPS-exposed individuals who are exposed to environmental toxicants." ..
  24. CD4+ T CELLS PROMOTE EARLY ATHEROSCLEROSIS
    Sally Huber; Fiscal Year: 2002
    ..Specific Aim 3 will investigate the role of CD4+ T cells in atherogenesis and evaluate whether these cells promote Th1 cell dominance. ..
  25. ROLE OF PKD IN LEUKOCYTE ACTIVATION BY CPG DNA
    Ae Kyung Yi; Fiscal Year: 2002
    ..This proposed study would enhance our understanding of how CpG motifs in bacterial DNA break immune tolerance and contribute to chrome inflammatory autoimmune diseases such as arthritis. ..
  26. RSV AND ASTHMA
    David Broide; Fiscal Year: 2003
    ..Overall these studies will contribute to our understanding of the mechanism of eosinophilic inflammation during RSV infection and suggest candidate vaccine strategies to inhibit RSV infection and airway inflammation. ..
  27. EXPERIMENTAL RADIOTHERAPY--CARCINOGENESIS, AND PROTECTOR
    DAVID GRDINA; Fiscal Year: 2003
    ..abstract_text> ..
  28. CHEMOKINES IN LUNG DISEASE OF HIV1 TRANSGENIC MICE
    Paul Jolicoeur; Fiscal Year: 2003
    ..4- To determine whether blocking or deleting specific chemokines or their receptors and overexpressing some chemokine receptors alter the development of lymphocytic interstitial pneumonitis. ..
  29. 37th Annual Meeting of the Society for Leukocyte Biology
    Joshua Fierer; Fiscal Year: 2004
    ..We encourage students and other trainees to submit abstracts; the SLB gives awards for the best abstracts submitted by students. One of the main purposes of the meeting is to encourage young scientists. ..
  30. Innate Immunity to Salmonella Infections
    Joshua Fierer; Fiscal Year: 2005
    ..We will compare isogenic strains of salmonella that express either the group B or 0 LPS antigens in C3 deficient and neutropenic mice, in order to determine how the structure of the LPS affects virulence in mice. ..
  31. CDI and Gamma Delta+ in Viral Myocarditis
    Sally Huber; Fiscal Year: 2005
    ..abstract_text> ..
  32. Biomarkers in sputum in COPD
    David Broide; Fiscal Year: 2005
    ..abstract_text> ..
  33. Epo-dependent JAK2 Signaling in Painful Neuropathy
    WENDY CAMPANA; Fiscal Year: 2006
    ..The experiments will provide new information on the basic mechanisms of nerve injury and pain, and there from, new rationale for development of novel neuroprotective strategies for preventing chronic neuropathic pain. ..
  34. Delayed Radioprotection by Thiols
    DAVID GRDINA; Fiscal Year: 2006
    ..Two, elevation in MnSOD level without a concomitant increase in enzymatic activity can result from nitration of MnSOD by peroxynitrite (ONOO-). ..
  35. Akt activation sustains silica induced inflammation
    CELINE BEAMER; Fiscal Year: 2006
    ..abstract_text> ..
  36. Defending Against Systemic Mycoses
    GEORGE DEEPE; Fiscal Year: 2008
    ..The collaborative and synergistic effort manifested by this group of investigators will provide new and exciting information regarding prevention and/or treatment of these problematic fungi. ..
  37. PROTECTIVE ANTIGENS FROM HISTOPLASMA CAPSULATUM
    GEORGE DEEPE; Fiscal Year: 2007
    ..abstract_text> ..
  38. Development of Cellular Assays of Dengue Virus Infection
    Priscilla Yang; Fiscal Year: 2008
    ..These inhibitors can be used to study how dengue virus interacts with its host, and they may also be useful in developing therapies for the treatment of dengue virus infections. [unreadable] [unreadable] [unreadable]..
  39. Eosinophil Trafficking
    David Broide; Fiscal Year: 2005
    ..Overall, these studies should improve our understanding of the molecular mechanism of eosinophil recruitment in vivo and its effect on airway structure and function. ..
  40. PROTEIN PROFILING OF ORAL MUCOSA OF HIV TRANSGENIC MICE
    Paul Jolicoeur; Fiscal Year: 2010
    ..This research is especially relevant to public health in view of the high frequency of oral complications (especially candidiasis) in HIV-1 infected individuals. ..
  41. ENDOTHELIUM--SIGNALING FROM MAST CELLS TO EOSINOPHILS
    David Broide; Fiscal Year: 2002
    ....
  42. IMMUNE PROMOTION OF REMYELINATION
    Moses Rodriguez; Fiscal Year: 2008
    ..Our findings are expected to provide new insights into the enhancement of remyelination in diseases such as multiple sclerosis. [unreadable] [unreadable]..
  43. DIETARY LIPIDS AND EXPERIMENTAL IGA NEPHROPATHY
    James Pestka; Fiscal Year: 2009
    ..abstract_text> ..