Tnfaip3

Summary

Gene Symbol: Tnfaip3
Description: tumor necrosis factor, alpha-induced protein 3
Alias: A20, Tnfip3, tumor necrosis factor alpha-induced protein 3, TNF alpha-induced protein 3, tumor necrosis factor induced protein 3, zinc finger protein A20
Species: mouse

Top Publications

  1. ncbi Identification of a novel A20-binding inhibitor of nuclear factor-kappa B activation termed ABIN-2
    S Van Huffel
    Department of Molecular Biology, Unit for Molecular Signal Transduction in Inflammation, Flanders Interuniversity Institute for Biotechnology and Ghent University, 9000 Ghent, Belgium
    J Biol Chem 276:30216-23. 2001
  2. pmc A20 protects mice from lethal liver ischemia/reperfusion injury by increasing peroxisome proliferator-activated receptor-alpha expression
    Haley E Ramsey
    Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Liver Transpl 15:1613-21. 2009
  3. pmc Keratinocyte-specific ablation of the NF-κB regulatory protein A20 (TNFAIP3) reveals a role in the control of epidermal homeostasis
    S Lippens
    Department for Molecular Biomedical Research, VIB, University Ghent, Ghent, Belgium
    Cell Death Differ 18:1845-53. 2011
  4. pmc Enterocyte-specific A20 deficiency sensitizes to tumor necrosis factor-induced toxicity and experimental colitis
    Lars Vereecke
    Department for Molecular Biomedical Research, VIB, B 9052 Ghent, Belgium
    J Exp Med 207:1513-23. 2010
  5. pmc The ubiquitin modifying enzyme A20 restricts B cell survival and prevents autoimmunity
    Rita M Tavares
    Department of Medicine, University of California, San Francisco, San Francisco, CA, USA
    Immunity 33:181-91. 2010
  6. doi B cells lacking the tumor suppressor TNFAIP3/A20 display impaired differentiation and hyperactivation and cause inflammation and autoimmunity in aged mice
    Yuanyuan Chu
    Max Planck Institute of Biochemistry, Martinsried, Germany
    Blood 117:2227-36. 2011
  7. pmc Inhibition of NF-kappaB signaling by A20 through disruption of ubiquitin enzyme complexes
    Noula Shembade
    Department of Microbiology and Immunology, Sylvester Comprehensive Cancer Center, The University of Miami, Miller School of Medicine, Miami, FL 33136, USA
    Science 327:1135-9. 2010
  8. pmc A20 is an early responding negative regulator of Toll-like receptor 5 signalling in intestinal epithelial cells during inflammation
    N Oshima
    Department of Internal Medicine II, Shimane University School of Medicine, Izumo, Shimane, Japan
    Clin Exp Immunol 159:185-98. 2010
  9. pmc O-glycosylation regulates ubiquitination and degradation of the anti-inflammatory protein A20 to accelerate atherosclerosis in diabetic ApoE-null mice
    Gautam V Shrikhande
    The Division of Vascular Surgery, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 5:e14240. 2010
  10. pmc Ubiquitin-editing enzyme A20 promotes tolerance to lipopolysaccharide in enterocytes
    Jin Wang
    Division of Pediatric Surgery, Childrens Hospital Los Angeles, Los Angeles, CA 90027, USA
    J Immunol 183:1384-92. 2009

Scientific Experts

  • Wu Xu
  • Nirjari V Dalal
  • Fuminori Tokunaga
  • Chong Shan Shi
  • H L Huang
  • Noula Shembade
  • Averil Ma
  • Rudi Beyaert
  • Barbara A Malynn
  • Rommel Advincula
  • Geert Van Loo
  • Emre E Turer
  • Eva Csizmadia
  • Christiane Ferran
  • Julio Barrera
  • Lars Vereecke
  • Mozes Sze
  • Cleide G da Silva
  • Michio Onizawa
  • Shigeru Oshima
  • Yuanyuan Chu
  • Peter Studer
  • Scott M Damrauer
  • Virendra I Patel
  • David L Boone
  • Renata Padilha Guedes
  • Osamu Hitotsumatsu
  • Jonathan Maelfait
  • Conor Mc Guire
  • Lauren E Kolodziej
  • Lesley Rhee
  • Bangxing Hong
  • Mirjam Kool
  • Manolis Pasparakis
  • Karen Heyninck
  • Marc Schmidt-Supprian
  • Jeffrey J Siracuse
  • Rita M Tavares
  • Gautam V Shrikhande
  • Soizic Daniel
  • Gippeum Joy Lee
  • Makiko Fukaya
  • Luoyan Ai
  • Masashi Kanayama
  • Ming chuan Li
  • Noritaka Yamaguchi
  • Bao H Duong
  • Alma Burlingame
  • Yu Matsuzawa
  • Masahiro Marshall Nakagawa
  • Shuying Chen
  • Juan A Oses-Prieto
  • CHOZHA VENDAN RATHINAM
  • Christopher R Longo
  • Hao Wu
  • Arnab De
  • Bao Duong
  • Timothy T Lu
  • Yingke Li
  • Ling Shao
  • Jun Gui
  • LiFeng Wang
  • Rakshita A Charan
  • Supriya Srivastav
  • Jiao Sun
  • Jie Yang
  • Yusuke Sakai
  • Xue F Huang
  • Rita Tavares
  • James P Lodolce
  • Jonathan E Chang
  • Jeannette S Messer
  • Sarah J Bartulis
  • Stephen F Murphy
  • Si Yi Chen
  • Min Wang
  • Wesley A Grimm
  • Jan L Breslow
  • Boris Reizis
  • S Lippens
  • Linlin Gao
  • Mourad Matmati
  • Rodolfo Niño Fong
  • Dirk Elewaut
  • Susanne Billmann-Born
  • Jiahua Yu
  • Yanbao Xiong
  • Bart N Lambrecht
  • Nadine Hövelmeyer
  • Gianna Elena Hammer

Detail Information

Publications79

  1. ncbi Identification of a novel A20-binding inhibitor of nuclear factor-kappa B activation termed ABIN-2
    S Van Huffel
    Department of Molecular Biology, Unit for Molecular Signal Transduction in Inflammation, Flanders Interuniversity Institute for Biotechnology and Ghent University, 9000 Ghent, Belgium
    J Biol Chem 276:30216-23. 2001
    ..The zinc finger protein A20 is a cellular inhibitor of NF-kappaB activation by various stimuli and plays a critical role in ..
  2. pmc A20 protects mice from lethal liver ischemia/reperfusion injury by increasing peroxisome proliferator-activated receptor-alpha expression
    Haley E Ramsey
    Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Liver Transpl 15:1613-21. 2009
    The nuclear factor-kappaB inhibitory protein A20 demonstrates hepatoprotective abilities through combined antiapoptotic, anti-inflammatory, and pro-proliferative functions...
  3. pmc Keratinocyte-specific ablation of the NF-κB regulatory protein A20 (TNFAIP3) reveals a role in the control of epidermal homeostasis
    S Lippens
    Department for Molecular Biomedical Research, VIB, University Ghent, Ghent, Belgium
    Cell Death Differ 18:1845-53. 2011
    The ubiquitin-editing enzyme A20 (tumor necrosis factor-α-induced protein 3) serves as a critical brake on nuclear factor κB (NF-κB) signaling...
  4. pmc Enterocyte-specific A20 deficiency sensitizes to tumor necrosis factor-induced toxicity and experimental colitis
    Lars Vereecke
    Department for Molecular Biomedical Research, VIB, B 9052 Ghent, Belgium
    J Exp Med 207:1513-23. 2010
    b>A20 is a nuclear factor kappaB (NF-kappaB) target gene that encodes a ubiquitin-editing enzyme that is essential for the termination of NF-kappaB activation after tumor necrosis factor (TNF) or microbial product stimulation and for the ..
  5. pmc The ubiquitin modifying enzyme A20 restricts B cell survival and prevents autoimmunity
    Rita M Tavares
    Department of Medicine, University of California, San Francisco, San Francisco, CA, USA
    Immunity 33:181-91. 2010
    ..Given recent data linking A20 (TNFAIP3) with human B cell lymphomas and systemic lupus erythematosus (SLE), we have generated mice bearing a floxed ..
  6. doi B cells lacking the tumor suppressor TNFAIP3/A20 display impaired differentiation and hyperactivation and cause inflammation and autoimmunity in aged mice
    Yuanyuan Chu
    Max Planck Institute of Biochemistry, Martinsried, Germany
    Blood 117:2227-36. 2011
    The ubiquitin-editing enzyme A20/TNFAIP3 is essential for controlling signals inducing the activation of nuclear factor-κB transcription factors...
  7. pmc Inhibition of NF-kappaB signaling by A20 through disruption of ubiquitin enzyme complexes
    Noula Shembade
    Department of Microbiology and Immunology, Sylvester Comprehensive Cancer Center, The University of Miami, Miller School of Medicine, Miami, FL 33136, USA
    Science 327:1135-9. 2010
    b>A20 negatively regulates inflammation by inhibiting the nuclear factor kappaB (NF-kappaB) transcription factor in the tumor necrosis factor-receptor (TNFR) and Toll-like receptor (TLR) pathways...
  8. pmc A20 is an early responding negative regulator of Toll-like receptor 5 signalling in intestinal epithelial cells during inflammation
    N Oshima
    Department of Internal Medicine II, Shimane University School of Medicine, Izumo, Shimane, Japan
    Clin Exp Immunol 159:185-98. 2010
    ..receptor (TLR)-mediated inflammatory responses and restore immune system balance, including the zinc-finger protein A20, a negative regulator of TLR signalling that inhibits nuclear factor kappa B (NF-kappaB) activity...
  9. pmc O-glycosylation regulates ubiquitination and degradation of the anti-inflammatory protein A20 to accelerate atherosclerosis in diabetic ApoE-null mice
    Gautam V Shrikhande
    The Division of Vascular Surgery, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 5:e14240. 2010
    ..Hyperglycemia is a recognized independent risk factor for heightened atherogenesis in diabetes mellitus (DM). However, our understanding of the mechanisms underlying glucose damage to the vasculature remains incomplete...
  10. pmc Ubiquitin-editing enzyme A20 promotes tolerance to lipopolysaccharide in enterocytes
    Jin Wang
    Division of Pediatric Surgery, Childrens Hospital Los Angeles, Los Angeles, CA 90027, USA
    J Immunol 183:1384-92. 2009
    ..lasts 20-26 h, temporally coincides with LPS-induced expression of the anti-inflammatory ubiquitin-editing enzyme A20. Small interfering RNA silencing of A20 prevents tolerance, whereas ectopic expression of A20 blocks responses to ..
  11. doi Frequent inactivation of A20 in B-cell lymphomas
    Motohiro Kato
    Cancer Genomics Project, Department of Pediatrics, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Nature 459:712-6. 2009
    ..of external stimuli; recent genetic studies have disclosed putative associations of polymorphic A20 (also called TNFAIP3) alleles with autoimmune disease risk...
  12. pmc Encoding NF-kappaB temporal control in response to TNF: distinct roles for the negative regulators IkappaBalpha and A20
    Shannon L Werner
    Signaling Systems Laboratory, Department of Chemistry and Biochemistry, University of California at San Diego, La Jolla, California 92093, USA
    Genes Dev 22:2093-101. 2008
    ..The second phase is defined by A20, whose inducible expression provides for a rheostat function by which other inflammatory stimuli can regulate TNF ..
  13. pmc The ubiquitin-editing enzyme A20 restricts nucleotide-binding oligomerization domain containing 2-triggered signals
    Osamu Hitotsumatsu
    UCSF Colitis Center, Gastroenterology Division, Department of Medicine, Program in Biomedical Sciences, University of California at San Francisco, San Francisco, CA 94143 0538, USA
    Immunity 28:381-90. 2008
    ..b>A20 is a ubiquitin-modifying enzyme that restricts tumor necrosis factor (TNF) receptor and Toll-like receptor (TLR) -..
  14. pmc Homeostatic MyD88-dependent signals cause lethal inflamMation in the absence of A20
    Emre E Turer
    Gastrointestinal Division, Department of Medicine, Biomedical Sciences Program, University of California, San Francisco, San Francisco, CA 94143, USA
    J Exp Med 205:451-64. 2008
    ..b>A20 is a ubiquitin-modifying enzyme that restricts exogenous TLR-induced signals...
  15. doi The E3 ligase Itch negatively regulates inflammatory signaling pathways by controlling the function of the ubiquitin-editing enzyme A20
    Noula Shembade
    Department of Microbiology and Immunology, Sylvester Comprehensive Cancer Center, The University of Miami, Miller School of Medicine, Miami, Florida 33136, USA
    Nat Immunol 9:254-62. 2008
    The ubiquitin-editing enzyme A20 is a critical negative regulator of inflammation and cytokine-mediated activation of the transcription factor NF-kappaB; however, little is known about the mechanisms of A20-mediated inactivation of ..
  16. doi A20 deficiency in B cells enhances B-cell proliferation and results in the development of autoantibodies
    Nadine Hövelmeyer
    Institute for Molecular Medicine, University Medical Center of the Johannes Gutenberg University of Mainz, Mainz, Germany
    Eur J Immunol 41:595-601. 2011
    A20/TNFAIP3 is an ubiquitin-editing enzyme, important for the regulation of the NF-κB pathway. Mutations in the TNFAIP3 gene have been linked to different human autoimmune disorders...
  17. pmc ABIN1 protein cooperates with TAX1BP1 and A20 proteins to inhibit antiviral signaling
    Linlin Gao
    Department of Microbiology and Immunology, Graduate Program in Cancer Biology, Sylvester Comprehensive Cancer Center, University of Miami, Miller School of Medicine, Miami, Florida 33136, USA
    J Biol Chem 286:36592-602. 2011
    ..Herein, we demonstrate that the A20 binding inhibitor of NF-κB 1 (ABIN1) is a novel negative regulator of antiviral signaling...
  18. pmc A20 promotes liver regeneration by decreasing SOCS3 expression to enhance IL-6/STAT3 proliferative signals
    Cleide G da Silva
    Division of Vascular and Endovascular Surgery, Center for Vascular Biology Research and the Transplant Institute, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Hepatology 57:2014-25. 2013
    Liver regeneration is of major clinical importance in the setting of liver injury, resection, and transplantation. A20, a potent antiinflammatory and nuclear factor kappa B (NF-κB) inhibitory protein, has established pro-proliferative ..
  19. pmc Expression of TNFAIP3 in intestinal epithelial cells protects from DSS- but not TNBS-induced colitis
    Lesley Rhee
    Department of Medicine, University of Chicago, Chicago, IL 60611, USA
    Am J Physiol Gastrointest Liver Physiol 303:G220-7. 2012
    ..How NF-κB activation in IEC prevents colitis is not fully understood. TNFα-induced protein 3 (TNFAIP3) is a NF-κB-induced gene that acts in a negative-feedback loop to inhibit NF-κB activation and also to inhibit ..
  20. pmc Failure to regulate TNF-induced NF-kappaB and cell death responses in A20-deficient mice
    E G Lee
    Department of Medicine, The University of Chicago, 5841 South Maryland Avenue, MC 6084, Chicago, IL 60637, USA
    Science 289:2350-4. 2000
    b>A20 is a cytoplasmic zinc finger protein that inhibits nuclear factor kappaB (NF-kappaB) activity and tumor necrosis factor (TNF)-mediated programmed cell death (PCD)...
  21. pmc A20 (Tnfaip3) deficiency in myeloid cells protects against influenza A virus infection
    Jonathan Maelfait
    Unit of Molecular Signal Transduction in Inflammation, Department for Molecular Biomedical Research, VIB, Ghent, Belgium corrected
    PLoS Pathog 8:e1002570. 2012
    ..Here we used myeloid cell specific A20 knockout mice to examine the role of the ubiquitin-editing protein A20 in the response of myeloid cells to IAV ..
  22. pmc TNFAIP3 maintains intestinal barrier function and supports epithelial cell tight junctions
    Lauren E Kolodziej
    Department of Medicine, University of Chicago, Chicago, Illinois, United States of America
    PLoS ONE 6:e26352. 2011
    ..TNF alpha-induced protein 3 (TNFAIP3) is a cytosolic protein that acts in a negative feedback loop to regulate cell signaling induced by Toll-like ..
  23. pmc Expression of A20 by dendritic cells preserves immune homeostasis and prevents colitis and spondyloarthritis
    Gianna Elena Hammer
    Department of Medicine, University of California at San Francisco, San Francisco, California, USA
    Nat Immunol 12:1184-93. 2011
    ..Here we show that mice lacking the ubiquitin-editing molecule A20 specifically in DCs spontaneously showed DC activation and population expansion of activated T cells...
  24. pmc A20, a regulator of NFkappaB, maps to an atherosclerosis locus and differs between parental sensitive C57BL/6J and resistant FVB/N strains
    Susanne Idel
    Laboratory of Biochemical Genetics and Metabolism, The Rockefeller University, Box 179, 1230 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 100:14235-40. 2003
    ..A candidate gene in this region is A20, which is involved in the feedback suppression of NFkappaB activation induced by tumor necrosis factor alpha (..
  25. ncbi The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses
    David L Boone
    Department of Medicine, University of California at San Francisco, San Francisco, California 94143 0451, USA
    Nat Immunol 5:1052-60. 2004
    b>A20 is a cytoplasmic protein required for the termination of tumor necrosis factor (TNF)-induced signals...
  26. ncbi Nuclear factor-kappaB regulates beta-cell death: a critical role for A20 in beta-cell protection
    David Liuwantara
    Arthritis and Inflammation Program, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia
    Diabetes 55:2491-501. 2006
    ..Using oligonucleotide microarrays and real-time PCR, we identified TNFAIP3/A20 as the most highly regulated antiapoptotic gene expressed in cytokine-stimulated human and mouse islets...
  27. ncbi Targeted cardiac overexpression of A20 improves left ventricular performance and reduces compensatory hypertrophy after myocardial infarction
    Hong Liang Li
    National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100005, PR China
    Circulation 115:1885-94. 2007
    b>A20 was originally characterized as a tumor necrosis factor-inducible gene in human umbilical vein endothelial cells...
  28. doi A20 (TNFAIP3) deficiency in myeloid cells triggers erosive polyarthritis resembling rheumatoid arthritis
    Mourad Matmati
    Department for Molecular Biomedical Research, Unit of Molecular Signal Transduction in Inflammation, Vlaams Instituut voor Biotechnologie, Ghent, Belgium
    Nat Genet 43:908-12. 2011
    A20 (TNFAIP3) is a protein that is involved in the negative feedback regulation of NF-κB signaling in response to specific proinflammatory stimuli in different cell types and has been suggested as a susceptibility gene for rheumatoid ..
  29. pmc IkappaB kinase beta phosphorylates the K63 deubiquitinase A20 to cause feedback inhibition of the NF-kappaB pathway
    Jessica E Hutti
    Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, USA
    Mol Cell Biol 27:7451-61. 2007
    ..This approach predicted Ser381 of the K63 deubiquitinase A20 as a likely site of IKKbeta phosphorylation...
  30. doi The ubiquitin-editing protein A20 prevents dendritic cell activation, recognition of apoptotic cells, and systemic autoimmunity
    Mirjam Kool
    Laboratory of Immunoregulation, Department of Pulmonary Medicine, University Hospital Gent, 9000 Gent, Belgium
    Immunity 35:82-96. 2011
    ..Here we have shown that the ubiquitin editing enzyme A20 (Tnfaip3) determines the activation threshold of DCs, via control of canonical NF-κB activation...
  31. pmc The protective effect of A20 on atherosclerosis in apolipoprotein E-deficient mice is associated with reduced expression of NF-kappaB target genes
    Susanne Wolfrum
    Laboratory of Biochemical Genetics and Metabolism, The Rockefeller University, New York, NY 10065
    Proc Natl Acad Sci U S A 104:18601-6. 2007
    ..One key regulator of inflammation is the A20 (also called TNF-alpha-induced protein 3 or Tnfaip3) gene, which is responsible for NF-kappaB termination and maps to an atherosclerosis susceptibility locus ..
  32. pmc The deubiquitinase activity of A20 is dispensable for NF-κB signaling
    Arnab De
    Department of Microbiology and Immunology, College of Physicians and Surgeons Columbia University, New York, NY, USA
    EMBO Rep 15:775-83. 2014
    b>A20 has been suggested to limit NF-κB activation by removing regulatory ubiquitin chains from ubiquitinated substrates...
  33. pmc A20 restricts wnt signaling in intestinal epithelial cells and suppresses colon carcinogenesis
    Ling Shao
    Department of Medicine, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 8:e62223. 2013
    ..Here, we have studied the role of A20 (also known as TNFAIP3), a ubiquitin-editing enzyme that restricts NFκB and cell death signaling, in intestinal homeostasis and ..
  34. doi A20 reduces lipid storage and inflammation in hypertrophic adipocytes via p38 and Akt signaling
    Luoyan Ai
    Department of Health Manage Center, School of Medicine, Ren Ji Hospital, Shanghai Jiao Tong University, No 160, Pujian Road, Shanghai, China
    Mol Cell Biochem 420:73-83. 2016
    ..Adipose tissue plays a vital role in the development of obesity and related disorders. Our previous study showed that A20, an ubiquitin-editing enzyme with anti-inflammation function, attenuated free fatty acids (FFAs)-induced lipid ..
  35. doi MicroRNA-873 Inhibits Morphine-Induced Macrophage Apoptosis by Elevating A20 Expression
    Ming chuan Li
    Department of Anesthesiology, Yantai Yuhuangding Hospital, Affiliated Hospital of Medical College, Qingdao University, Yantai
    Pain Med 16:1993-9. 2015
    ....
  36. doi A20 Inhibits β-Cell Apoptosis by Multiple Mechanisms and Predicts Residual β-Cell Function in Type 1 Diabetes
    Makiko Fukaya
    Université Libre de Bruxelles Center for Diabetes Research M F, K M, D D, E C V, A K C, Free University Brussels, 1070 Brussels, Belgium Copenhagen Diabetes Research Center C A B, L B N, M L A, H B M, F P, J S, Department of Pediatrics E, Copenhagen University Hospital Herlev, DL 2730 Herlev, Denmark Inflammation Research Center L C, R B, G V L, Vlaams Instituut voor Biotechnologie, 9052 Gent, Belgium Department of Biomedical Molecular Biology L C, R B, G V L, 9052 Gent University, Gent, Belgium Laboratory of Endocrine Pancreas and Metabolism E C V, Department of Structural and Functional Biology, Institute of Biology, State University of Campinas, 13083 970 Campinas, Brazil and Department of Development and Cellular Biology F O, Institute of Biomedical Sciences, 05508 900 São Paulo University, MD
    Mol Endocrinol 30:48-61. 2016
    ..association studies have identified the gene TNF-induced protein 3 (TNFAIP3), encoding for the zinc finger protein A20, as a susceptibility locus for T1D...
  37. doi Mycobacterium fortuitum induces A20 expression that impairs macrophage inflammatory responses
    Gippeum Joy Lee
    Department of Microbiology, College of Medicine, Chungnam National University, Daejeon 301 747, South Korea Infection Signaling Network Research Center, College of Medicine, Chungnam National University, Daejeon 301 747, South Korea
    Pathog Dis 74:. 2016
    ..study, we report that MF infection leads to the induction of an anti-inflammatory molecule, A20 (also known as TNFAIP3), which is essential for the regulation of MF-induced inflammatory responses in murine bone marrow-derived ..
  38. doi Up-regulated A20 promotes proliferation, regulates cell cycle progression and induces chemotherapy resistance of acute lymphoblastic leukemia cells
    Shuying Chen
    State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 288 Nanjing Road, Tianjin 300020, PR China
    Leuk Res 39:976-83. 2015
    A20, also known as tumor necrosis factor-α (TNFα)-induced protein 3 (TNFAIP3), has been identified as a key regulator of cell survival in many solid tumors...
  39. pmc TNFAIP3 promotes survival of CD4 T cells by restricting MTOR and promoting autophagy
    Yu Matsuzawa
    a Department of Gastroenterology and Hepatology Graduate School Tokyo Medical and Dental University Tokyo, Japan
    Autophagy 11:1052-62. 2015
    Autophagy plays important roles in metabolism, differentiation, and survival in T cells. TNFAIP3/A20 is a ubiquitin-editing enzyme that is thought to be a negative regulator of autophagy in cell lines...
  40. pmc The ubiquitin-modifying enzyme A20 restricts ubiquitination of the kinase RIPK3 and protects cells from necroptosis
    Michio Onizawa
    Department of Medicine, University of California, San Francisco, San Francisco, California, USA
    Nat Immunol 16:618-27. 2015
    b>A20 is an anti-inflammatory protein linked to multiple human diseases; however, the mechanisms by which A20 prevents inflammatory disease are incompletely defined...
  41. doi The seventh zinc finger motif of A20 is required for the suppression of TNF-α-induced apoptosis
    Noritaka Yamaguchi
    Department of Molecular Cell Biology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 260 8675, Japan Electronic address
    FEBS Lett 589:1369-75. 2015
    The ubiquitin-editing enzyme A20 suppresses nuclear factor-κB (NF-κB) activation and tumor necrosis factor-α (TNF-α)-induced apoptosis in a deubiquitinating and ubiquitin ligase activity-dependent manner...
  42. pmc Lack of the ubiquitin-editing enzyme A20 results in loss of hematopoietic stem cell quiescence
    Masahiro Marshall Nakagawa
    Department of Genetics and Development, Institute for Cancer Genetics, and Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032
    J Exp Med 212:203-16. 2015
    ..The ubiquitin-editing enzyme A20 functions as a central regulator of inflammation and adaptive immunity...
  43. pmc Autophagy enhances NFκB activity in specific tissue macrophages by sequestering A20 to boost antifungal immunity
    Masashi Kanayama
    Department of Immunology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nat Commun 6:5779. 2015
    ..Here we report a role of autophagy in an early host antifungal response by enhancing NFκB activity through A20 sequestration...
  44. pmc A20 restricts ubiquitination of pro-interleukin-1β protein complexes and suppresses NLRP3 inflammasome activity
    Bao H Duong
    Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA
    Immunity 42:55-67. 2015
    ..The NF-κB inhibitor A20 is a ubiquitin-modifying enzyme that might be critical in preventing human inflammatory diseases...
  45. doi A20 controls intestinal homeostasis through cell-specific activities
    Lars Vereecke
    1 Unit of Molecular Signal Transduction in Inflammation, Inflammation Research Center, VIB, Technologiepark 927, B 9052 Ghent, Belgium 2 Department of Biomedical Molecular Biology, Ghent University, Technologiepark 927, B 9052 Ghent, Belgium
    Nat Commun 5:5103. 2014
    ..b>A20, an inhibitor of both NF-κB and apoptotic signalling, was identified as a susceptibility gene for multiple ..
  46. pmc A20 deficiency causes spontaneous neuroinflammation in mice
    Renata Padilha Guedes
    Division of Vascular Surgery, Center for Vascular Biology Research and the Transplant Institute, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    J Neuroinflammation 11:122. 2014
    A20 (TNFAIP3) is a pleiotropic NFκB-dependent gene that terminates NFκB activation in response to inflammatory stimuli. The potent anti-inflammatory properties of A20 are well characterized in several organs...
  47. pmc Specific recognition of linear polyubiquitin by A20 zinc finger 7 is involved in NF-κB regulation
    Fuminori Tokunaga
    Laboratory of Molecular Cell Biology, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Gunma, Japan
    EMBO J 31:3856-70. 2012
    ..However, the regulatory mechanism of LUBAC-mediated NF-κB activation remains elusive. Here, we show that A20 suppresses LUBAC-mediated NF-κB activation by binding linear polyubiquitin via the C-terminal seventh zinc finger (..
  48. pmc A20 controls macrophage to elicit potent cytotoxic CD4(+) T cell response
    LiFeng Wang
    Norris Comprehensive Cancer Center, Department of Molecular Microbiology and Immunology, University of Southern California Keck School of Medicine, Los Angeles, CA, USA
    PLoS ONE 7:e48930. 2012
    ..of our work that aims at promoting immunostimulation of APCs by inhibition of negative regulators, we found that A20-silenced Mф drastically induced granzyme B expression in CD4(+) T cells...
  49. doi TRAF6 and A20 regulate lysine 63-linked ubiquitination of Beclin-1 to control TLR4-induced autophagy
    Chong Shan Shi
    B Cell Molecular Immunology Section, Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Sci Signal 3:ra42. 2010
    ..The deubiquitinating enzyme A20 reduced the extent of K63-linked ubiquitination of Beclin-1 and limited the induction of autophagy in response to ..
  50. pmc A20 (TNFAIP3) alleviates CVB3-induced myocarditis via inhibiting NF-κB signaling
    Jun Gui
    Institute for Immunobiology, Shanghai Medical College, Fudan University, Shanghai, People s Republic of China
    PLoS ONE 7:e46515. 2012
    ..A20, also known as tumor necrosis factor alpha induced protein 3 (TNFAIP3) is a key negative regulator of inflammation...
  51. pmc RNF11 modulates microglia activation through NF-κB signalling cascade
    Nirjari V Dalal
    Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, GA 30322, United States
    Neurosci Lett 528:174-9. 2012
    ..RING finger protein 11 (RNF11), in association with A20 ubiquitin-editing complex, is one of the key negative regulators of NF-κB signalling pathway in neurons...
  52. pmc Zinc finger protein A20 protects rats against chronic liver allograft dysfunction
    Jie Yang
    Department of Liver and Vascular Surgery, Liver Transplantation Center, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
    World J Gastroenterol 18:3537-50. 2012
    To investigate the effect of zinc finger protein A20 on chronic liver allograft dysfunction in rats.
  53. doi A20 is up-regulated in primary mouse hepatocytes subjected to hypoxia and reperfusion
    Jiao Sun
    Department of Pathophysiology, College of Basic Medical Sciences, China Medical University, Shenyang, China
    Cell Biochem Funct 30:683-6. 2012
    ..b>Zinc finger protein A20, mercaptopyruvate sulfur transferase, apolipoprotein E precursor and carbamoyl-phosphate synthase ..
  54. doi Leishmania donovani exploits host deubiquitinating enzyme A20, a negative regulator of TLR signaling, to subvert host immune response
    Supriya Srivastav
    Indian Institute of Chemical Biology, Kolkata, India
    J Immunol 189:924-34. 2012
    ..L. donovani infection drastically reduced Lys 63-linked ubiquitination of TRAF6, and the deubiquitinating enzyme A20 was found to be significantly upregulated in infected macrophages...
  55. doi A20 and ABIN-3 possibly promote regression of trehalose 6,6'-dimycolate (TDM)-induced granuloma by interacting with an NF-kappa B signaling protein, TAK-1
    Yusuke Sakai
    Laboratory of Comparative Pathology, Graduated School of Veterinary Medicine, Hokkaido University, N18 W9, Kita ku, Sapporo 060 0818, Japan
    Inflamm Res 61:245-53. 2012
    The objective of this paper is to examine the role of NF-kappa B inhibitors A20 and ABIN-family proteins in the trehalose 6,6'-dimycolate (TDM)-induced model of tuberculous granulomatous lesions.
  56. ncbi Structure-function analysis of the A20-binding inhibitor of NF-kappa B activation, ABIN-1
    Karen Heyninck
    Department of Molecular Biomedical Research, Unit of Molecular Signal Transduction in Inflammation, Flanders Interuniversity Institute for Biotechnology, Ghent University, K L Ledeganckstraat 35, B 9000 Ghent, Belgium
    FEBS Lett 536:135-40. 2003
    ..Among others, the NF-kappa B-dependent zinc finger protein A20 is involved in the negative feedback regulation of NF-kappa B activation in response to tumor necrosis ..
  57. doi Deubiquitinating enzyme A20 negatively regulates NF-κB signaling in skeletal muscle in mdx mice
    Rakshita A Charan
    Neurology Service, Department of Veterans Affairs Medical Center, Pittsburgh, Pennsylvania, USA
    FASEB J 26:587-95. 2012
    ..A20 (TNFAIP3) is a critical negative regulator of NF-κB...
  58. pmc Induction of endotoxin tolerance in vivo inhibits activation of IRAK4 and increases negative regulators IRAK-M, SHIP-1, and A20
    Yanbao Xiong
    Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, USA
    J Leukoc Biol 90:1141-8. 2011
    ..TLR4-driven IRAK4 phosphorylation and activation in macrophages, while increasing expression of IRAK-M, SHIP-1, A20 mRNA, and A20 protein...
  59. pmc Essential role for TAX1BP1 in the termination of TNF-alpha-, IL-1- and LPS-mediated NF-kappaB and JNK signaling
    Noula Shembade
    Department of Microbiology and Immunology, Sylvester Comprehensive Cancer Center, Miller School of Medicine, The University of Miami, Miami, FL 33136, USA
    EMBO J 26:3910-22. 2007
    ..The ubiquitin editing enzyme A20 serves an essential role in the termination of TNF-alpha- and LPS-mediated NF-kappaB signaling by inactivating key ..
  60. pmc The kinase IKKα inhibits activation of the transcription factor NF-κB by phosphorylating the regulatory molecule TAX1BP1
    Noula Shembade
    Department of Microbiology and Immunology, Sylvester Comprehensive Cancer Center, The University of Miami, Miller School of Medicine, Miami, Florida, USA
    Nat Immunol 12:834-43. 2011
    In response to stimulation with proinflammatory cytokines, the deubiquitinase A20 inducibly interacts with the regulatory molecules TAX1BP1, Itch and RNF11 to form the A20 ubiquitin-editing complex...
  61. pmc Dimerization and ubiquitin mediated recruitment of A20, a complex deubiquitinating enzyme
    Timothy T Lu
    Department of Medicine, University of California, San Francisco, San Francisco, CA 94143 0451, USA
    Immunity 38:896-905. 2013
    ..functions, we generated two lines of gene-targeted mice, abrogating either A20's deubiquitinating activity (Tnfaip3(OTU) mice) or A20's ZF4 (Tnfaip3(ZF4) mice)...
  62. pmc Immune responsive gene 1 (IRG1) promotes endotoxin tolerance by increasing A20 expression in macrophages through reactive oxygen species
    Yingke Li
    National Key Laboratory of Medical Immunology and Institute of Immunology, Second Military Medical University, Shanghai 200433, China
    J Biol Chem 288:16225-34. 2013
    ..IL-6, and IFN-β in LPS-tolerized macrophages, with the elevated expression of reactive oxygen species (ROS) and A20. Moreover, ROS enhanced A20 expression by increasing the H3K4me3 modification of histone on the A20 promoter domain,..
  63. pmc Uncoupling protein-2 increases nitric oxide production and TNFAIP3 pathway activation in pancreatic islets
    Rodolfo Niño Fong
    Department of Biomedical Sciences, University of Prince Edward Island, Charlottetown, Prince Edward Island, Canada C1A 4P3
    J Mol Endocrinol 46:193-204. 2011
    ..Proliferation (cyclin D2, Ccnd2) and anti-apoptosis (Tnfaip3) genes had increased expression in Ucp2(-/-) islets, whereas the mRNA of pro-apoptosis genes (Jun, Myc) was ..
  64. pmc The zinc finger protein A20 targets TRAF2 to the lysosomes for degradation
    Lianyun Li
    Building 5, Room 433, Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health 5, Center Drive, Bethesda, MD 20892, USA
    Biochim Biophys Acta 1793:346-53. 2009
    The zinc finger-containing protein A20 is a negative regulator of TNF-induced JNK (c-Jun-N-terminal kinase) and NFkappaB (nuclear factor kappaB) signaling...
  65. ncbi Major histocompatibility complex class I- and II-deficient knock-out mice are resistant to primary but susceptible to secondary Eimeria papillata infections
    M L Schito
    Department of Pathobiology, Ontario Veterinary College, University of Guelph, Canada
    Parasitol Res 84:394-8. 1998
    ..The mechanism of resistance depends on the immune status of the host and requires the coordinated interaction of both alphabeta+ T-cell subsets for optimal parasite control during subsequent infections...
  66. pmc The zinc finger protein A20 inhibits TNF-induced NF-kappaB-dependent gene expression by interfering with an RIP- or TRAF2-mediated transactivation signal and directly binds to a novel NF-kappaB-inhibiting protein ABIN
    K Heyninck
    Department of Molecular Biology, Flanders Interuniversity Institute for Biotechnology, University of Ghent, B 9000 Ghent, Belgium
    J Cell Biol 145:1471-82. 1999
    The zinc finger protein A20 is a tumor necrosis factor (TNF)- and interleukin 1 (IL-1)-inducible protein that negatively regulates nuclear factor-kappa B (NF-kappaB)-dependent gene expression...
  67. ncbi A20 protects mice from lethal radical hepatectomy by promoting hepatocyte proliferation via a p21waf1-dependent mechanism
    Christopher R Longo
    Immunobiology Research Center, Division of Vascular Surgery, and the Transplant Center, Department of Surgery, Harvard Medical School, Boston, MA 02215, USA
    Hepatology 42:156-64. 2005
    ..We demonstrate that A20 is part of the physiological response of hepatocytes to injury...
  68. ncbi TNF pretreatment interferes with mitochondrial apoptosis in the mouse liver by A20-mediated down-regulation of Bax
    Gabriele Sass
    Institute of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen Nuremberg, Erlangen, Germany
    J Immunol 179:7042-9. 2007
    ..Knockdown of TNF-alpha-induced-protein 3 (A20) restored mitochondrial apoptosis, Bax expression, and liver damage...
  69. doi T cell antigen receptor stimulation induces MALT1 paracaspase-mediated cleavage of the NF-kappaB inhibitor A20
    Beatrice Coornaert
    Department of Molecular Biology, Ghent University, B 9052 Ghent, Belgium
    Nat Immunol 9:263-71. 2008
    ..Here we show that T cell antigen receptor stimulation induced recruitment of the NF-kappaB inhibitor A20 into a complex of MALT1 and the adaptor protein Bcl-10, leading to MALT1-mediated processing of A20...
  70. pmc Inflammatory cardiac valvulitis in TAX1BP1-deficient mice through selective NF-kappaB activation
    Hidekatsu Iha
    Laboratory of Molecular Microbiology, Molecular Virology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 0460, USA
    EMBO J 27:629-41. 2008
    ..TAX1BP1-/- cells are more highly activated for NF-kappaB than control cells when stimulated with TNF-alpha or IL-1beta. Mechanistically, TAX1BP1 acts in NF-kappaB signalling as an essential adaptor between A20 and its targets.
  71. doi Genome-wide expression profiling identifies an impairment of negative feedback signals in the Crohn's disease-associated NOD2 variant L1007fsinsC
    Susanne Billmann-Born
    Institute of Clinical Molecular Biology, Christian Albrechts University, 24105 Kiel, Germany
    J Immunol 186:4027-38. 2011
    ..g., TNFAIP3 [A20] and IER3). This genotype-dependent regulation pattern was confirmed in primary human myelomonocytic cells...
  72. doi A20 overexpression inhibits low shear flow-induced CD14-positive monocyte recruitment to endothelial cells
    Wen Zeng
    Department of Anatomy, Key Lab for Biomechanics of Chongqing, Third Military Medical University, and Department of Otolaryngology, Southwest Hospital, Chongqing, China
    Biorheology 46:21-30. 2009
    To determine if A20, a zinc finger protein that mediates the inflammatory response, affects monocyte-endothelial cell-cell interactions induced by low shear flow.
  73. pmc Impaired TNFalpha-induced A20 expression in E1A/Ras-transformed cells
    H L Huang
    The Campbell Family Institute of Breast Cancer Research, Ontario Cancer Institute, University Health Network and Department of Medical Biophysics, University of Toronto, 620 University Avenue, Toronto, Ontario, Canada
    Br J Cancer 101:1555-64. 2009
    ..However, TNF also activates survival signals, including NF-kappaB activation and the subsequent expression of anti-apoptotic genes, leading to protection against TNF toxicity...
  74. pmc A20 inhibits post-angioplasty restenosis by blocking macrophage trafficking and decreasing adventitial neovascularization
    Scott M Damrauer
    The Division of Vascular Surgery, Department of Surgery and Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Atherosclerosis 211:404-8. 2010
    ..We have shown that the homeostatic protein A20 prevents neointimal hyperplasia by affecting endothelial cell (EC) and smooth muscle cell (SMC) responses to injury...
  75. pmc Candidate genes for chromosomes 6 and 10 quantitative trait loci for age-related retinal degeneration in mice
    Diego G Ogando
    Department of Biology, Loyola Marymount University, Los Angeles, CA 90045 2659, USA
    Mol Vis 16:1004-18. 2010
    ..The QTL were responsible for 21% and 9% of the variance in phenotypes, respectively. We focused on these two QTL to identify candidate genes...
  76. doi Aggravation of post-ischemic liver injury by overexpression of A20, an NF-κB suppressor
    Jiahua Yu
    Department of Biochemistry, Medical School and Diabetes Research Center, Chonbuk National University, Jeonju, Jeonbuk 561 756, Republic of Korea
    J Hepatol 55:328-36. 2011
    b>A20 is an intracellular ubiquitin-editing enzyme that plays an important role in the negative feedback regulation of NF-κB activation in response to a diverse range of stimuli...
  77. pmc Mucosal and systemic anti-HIV immunity controlled by A20 in mouse dendritic cells
    Bangxing Hong
    Department of Molecular Microbiology and Immunology, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California 90033, USA
    J Clin Invest 121:739-51. 2011
    ..In this study, we found that the ubiquitin-editing enzyme A20--an inducible feedback inhibitor of the TNFR, RIG-I, and TLR signaling pathways that broadly controls the ..
  78. ncbi Lymphoid expression and regulation of A20, an inhibitor of programmed cell death
    M Tewari
    Graduate Program in Cellular and Molecular Biology, University of Michigan Medical School, Ann Arbor 48109
    J Immunol 154:1699-706. 1995
    b>A20 is a cytokine-inducible primary response gene that encodes a protein that inhibits apoptosis. We cloned and characterized a murine A20 cDNA and mapped the gene to mouse chromosome 10, 3.5 centimorgans proximal to the c-myb locus...
  79. pmc A phenotype-sensitizing Apoe-deficient genetic background reveals novel atherosclerosis predisposition loci in the mouse
    Hayes M Dansky
    Laboratory of Biochemical Genetics and Metabolism, The Rockefeller University, New York, New York 10021, USA
    Genetics 160:1599-608. 2002
    ..In summary, two independently performed crosses between C57BL/6 and FVB/N Apoe-deficient mice have revealed several previously unreported atherosclerosis susceptibility loci that are distinct from loci linked to lipoprotein levels...