Tnf

Summary

Gene Symbol: Tnf
Description: tumor necrosis factor
Alias: DIF, TNF-a, TNF-alpha, TNFSF2, TNFalpha, Tnfa, Tnfsf1a, Tnlg1f, tumor necrosis factor, cachectin, tumor necrosis factor ligand 1f, tumor necrosis factor ligand superfamily member 2, tumor necrosis factor-alpha
Species: mouse

Top Publications

  1. ncbi Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-alpha
    M L Moss
    Department of Molecular Biochemistry, Glaxo Wellcome Research and Development Inc, Research Triangle Park, North Carolina 27709, USA
    Nature 385:733-6. 1997
  2. ncbi Tumor necrosis factor-alpha is required in the protective immune response against Mycobacterium tuberculosis in mice
    J L Flynn
    Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pennsylvania 15261, USA
    Immunity 2:561-72. 1995
  3. ncbi Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components
    O Takeuchi
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Japan
    Immunity 11:443-51. 1999
  4. ncbi Mast cell modulation of neutrophil influx and bacterial clearance at sites of infection through TNF-alpha
    R Malaviya
    Department of Pathology, Barnes Jewish Hospital, St Louis, Missouri 63110, USA
    Nature 381:77-80. 1996
  5. ncbi A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells
    R A Black
    Immunex Corporation, Seattle, Washington 98101, USA
    Nature 385:729-33. 1997
  6. pmc TNF-alpha is a critical negative regulator of type 1 immune activation during intracellular bacterial infection
    Anna Zganiacz
    Infectious Diseases Division, Centre for Gene Therapeutics, and Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    J Clin Invest 113:401-13. 2004
  7. pmc Characterization of tumor necrosis factor-deficient mice
    M W Marino
    Ludwig Institute for Cancer Research, New York Branch at Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 94:8093-8. 1997
  8. pmc Transcriptional activation of the NF-kappaB p65 subunit by mitogen- and stress-activated protein kinase-1 (MSK1)
    Linda Vermeulen
    Department of Molecular Biology, University of Gent VIB, K L Ledeganckstraat 35, B 9000 Gent, Belgium
    EMBO J 22:1313-24. 2003
  9. pmc Initiation of liver growth by tumor necrosis factor: deficient liver regeneration in mice lacking type I tumor necrosis factor receptor
    Y Yamada
    Department of Pathology, University of Washington, Seattle 98195, USA
    Proc Natl Acad Sci U S A 94:1441-6. 1997
  10. ncbi Mice deficient in tumor necrosis factor-alpha are resistant to skin carcinogenesis
    R J Moore
    Biological Therapy Laboratory, Imperial Cancer Research Fund, London, UK
    Nat Med 5:828-31. 1999

Research Grants

  1. Defending Against Systemic Mycoses
    GEORGE DEEPE; Fiscal Year: 2008
  2. PROTECTIVE ANTIGENS FROM HISTOPLASMA CAPSULATUM
    GEORGE DEEPE; Fiscal Year: 2007
  3. Zinc inhibition of endotoxemia in alcoholic liver injury
    Zhanxiang Zhou; Fiscal Year: 2010
  4. Zinc and Alcohol-Induced Oxidative Liver Injury
    Zhanxiang Zhou; Fiscal Year: 2009
  5. CD4+ T CELLS PROMOTE EARLY ATHEROSCLEROSIS
    Sally Huber; Fiscal Year: 2002
  6. T reg Cells in Myocarditis
    Sally A Huber; Fiscal Year: 2010
  7. Sex in Viral Myocarditis
    Sally Huber; Fiscal Year: 2004
  8. Metallothionein in Chronic Alcoholic Liver Injury
    Zhanxiang Zhou; Fiscal Year: 2004
  9. Sex in Myocarditis
    Sally Huber; Fiscal Year: 2008
  10. CDI and Gamma Delta+ in Viral Myocarditis
    Sally Huber; Fiscal Year: 2005

Detail Information

Publications203 found, 100 shown here

  1. ncbi Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-alpha
    M L Moss
    Department of Molecular Biochemistry, Glaxo Wellcome Research and Development Inc, Research Triangle Park, North Carolina 27709, USA
    Nature 385:733-6. 1997
    Tumour-necrosis factor-alpha (TNF-alpha) is a cytokine that contributes to a variety of inflammatory disease states...
  2. ncbi Tumor necrosis factor-alpha is required in the protective immune response against Mycobacterium tuberculosis in mice
    J L Flynn
    Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pennsylvania 15261, USA
    Immunity 2:561-72. 1995
    ..We have examined the extent to which tumor necrosis factor-alpha (TNF alpha) contributes to this disease using murine models in which the action of TNF alpha is ..
  3. ncbi Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components
    O Takeuchi
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Japan
    Immunity 11:443-51. 1999
    ..These results demonstrate that TLR2 and TLR4 recognize different bacterial cell wall components in vivo and TLR2 plays a major role in Gram-positive bacterial recognition...
  4. ncbi Mast cell modulation of neutrophil influx and bacterial clearance at sites of infection through TNF-alpha
    R Malaviya
    Department of Pathology, Barnes Jewish Hospital, St Louis, Missouri 63110, USA
    Nature 381:77-80. 1996
    ..The mast-cell chemoattractant TNF-alpha was implicated in the neutrophil response because TNF-alpha was locally released only in +/+ and W/Wv+MC mice,..
  5. ncbi A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells
    R A Black
    Immunex Corporation, Seattle, Washington 98101, USA
    Nature 385:729-33. 1997
    ..The release of soluble tumour-necrosis factor-alpha (TNF-alpha) from its membrane-bound precursor is one of the most intensively studied shedding events because this ..
  6. pmc TNF-alpha is a critical negative regulator of type 1 immune activation during intracellular bacterial infection
    Anna Zganiacz
    Infectious Diseases Division, Centre for Gene Therapeutics, and Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
    J Clin Invest 113:401-13. 2004
    b>TNF-alpha has long been regarded as a proimmune cytokine involved in antimicrobial type 1 immunity. However, the precise role of TNF-alpha in antimicrobial type 1 immunity remains poorly understood...
  7. pmc Characterization of tumor necrosis factor-deficient mice
    M W Marino
    Ludwig Institute for Cancer Research, New York Branch at Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 94:8093-8. 1997
    Although tumor necrosis factor (TNF) initially came to prominence because of its anti-tumor activity, most attention is now focused on its proinflammatory actions...
  8. pmc Transcriptional activation of the NF-kappaB p65 subunit by mitogen- and stress-activated protein kinase-1 (MSK1)
    Linda Vermeulen
    Department of Molecular Biology, University of Gent VIB, K L Ledeganckstraat 35, B 9000 Gent, Belgium
    EMBO J 22:1313-24. 2003
    ..as well as a potent mitogen- and stress- activated protein kinase-1 (MSK1) inhibitor H89, counteract tumor necrosis factor (TNF)-mediated stimulation of p65 transactivation capacity...
  9. pmc Initiation of liver growth by tumor necrosis factor: deficient liver regeneration in mice lacking type I tumor necrosis factor receptor
    Y Yamada
    Department of Pathology, University of Washington, Seattle 98195, USA
    Proc Natl Acad Sci U S A 94:1441-6. 1997
    ..growth, we studied the regeneration of the liver after partial hepatectomy (PH) in mice lacking type I tumor necrosis factor receptor (TNFR-I)...
  10. ncbi Mice deficient in tumor necrosis factor-alpha are resistant to skin carcinogenesis
    R J Moore
    Biological Therapy Laboratory, Imperial Cancer Research Fund, London, UK
    Nat Med 5:828-31. 1999
    ..cancer, we studied susceptibility to skin carcinogenesis in mice deficient for the pro-inflammatory cytokine TNF-alpha (refs. 5,6)...
  11. ncbi Murine hepatocyte apoptosis induced in vitro and in vivo by TNF-alpha requires transcriptional arrest
    M Leist
    Faculty of Biology, University of Konstanz, Germany
    J Immunol 153:1778-88. 1994
    Freshly isolated mouse hepatocytes were essentially insensitive to TNF-alpha cytotoxicity...
  12. ncbi An essential role for NF-kappaB in preventing TNF-alpha-induced cell death
    A A Beg
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 274:782-4. 1996
    ..In particular, the RelA (p65) subunit is required for induction of tumor necrosis factor-alpha (TNF-alpha)-dependent genes...
  13. pmc Immune and inflammatory responses in TNF alpha-deficient mice: a critical requirement for TNF alpha in the formation of primary B cell follicles, follicular dendritic cell networks and germinal centers, and in the maturation of the humoral immune response
    M Pasparakis
    Department of Molecular Genetics, Hellenic Pasteur Institute, Athens, Greece
    J Exp Med 184:1397-411. 1996
    To investigate the role of TNF alpha in the development of in vivo immune response we have generated TNF alpha-deficient mice by gene targeting...
  14. ncbi TNF-alpha induction by LPS is regulated posttranscriptionally via a Tpl2/ERK-dependent pathway
    C D Dumitru
    Kimmel Cancer Center, Department of Microbiology and Immunology, Thomas Jefferson University, 233 S 10th Street, Philadelphia, PA 19107, USA
    Cell 103:1071-83. 2000
    Tpl2 knockout mice produce low levels of TNF-alpha when exposed to lipopolysaccharide (LPS) and they are resistant to LPS/D-Galactosamine-induced pathology...
  15. ncbi Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU-rich elements: implications for joint and gut-associated immunopathologies
    D Kontoyiannis
    Laboratory of Molecular Genetics, Hellenic Pasteur Institute, Athens, Greece
    Immunity 10:387-98. 1999
    We addressed the impact of deleting TNF AU-rich elements (ARE) from the mouse genome on the regulation of TNF biosynthesis and the physiology of the host...
  16. ncbi Suppression of TNF-alpha-induced apoptosis by NF-kappaB
    D J Van Antwerp
    Laboratory of Genetics, Salk Institute, La Jolla, CA 92037, USA Jolla Institute for Allergy and Immu
    Science 274:787-9. 1996
    b>Tumor necrosis factor alpha (TNF-alpha) signaling gives rise to a number of events, including activation of transcription factor NF-kappaB and programmed cell death (apoptosis)...
  17. ncbi TRAF2 deficiency results in hyperactivity of certain TNFR1 signals and impairment of CD40-mediated responses
    L T Nguyen
    Department of Immunology, University of Toronto, Ontario, Canada
    Immunity 11:379-89. 1999
    b>Tumor necrosis factor (TNF) receptor-associated factor 2 (TRAF2) can interact with various members of the TNF receptor family. Previously, we reported that TRAF2-deficient mice die prematurely and have elevated serum TNF levels...
  18. pmc Lymph nodal prion replication and neuroinvasion in mice devoid of follicular dendritic cells
    Marco Prinz
    Institute of Neuropathology, University Hospital of Zurich, Schmelzbergstrasse 12, CH 8091 Zurich, Switzerland
    Proc Natl Acad Sci U S A 99:919-24. 2002
    ..Follicular dendritic cells (FDCs), whose development and maintenance in germinal centers depends on tumor necrosis factor (TNF) and lymphotoxin (LT) signaling, are thought to be indispensable for extraneural prion pathogenesis...
  19. ncbi Impaired fracture healing in the absence of TNF-alpha signaling: the role of TNF-alpha in endochondral cartilage resorption
    L C Gerstenfeld
    Orthopaedics Research Laboratory, Department of Orthopaedic Surgery, Boston University Medical Center, Boston, Massachusetts 02118, USA
    J Bone Miner Res 18:1584-92. 2003
    b>TNF-alpha is a major inflammatory factor that is induced in response to injury, and it contributes to the normal regulatory processes of bone resorption...
  20. ncbi Endogenous TNFalpha lowers maximum peak bone mass and inhibits osteoblastic Smad activation through NF-kappaB
    Yan Li
    Division of Endocrinology and Metabolism and Lipids, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Bone Miner Res 22:646-55. 2007
    Endogenous TNFalpha prevents the attainment of maximum achievable peak bone mass in vivo. In vitro, TNFalpha suppresses BMP-2- and TGFbeta-mediated Smad activation through induction of NF-kappaB...
  21. doi An essential role for transmembrane TNF in the resolution of the inflammatory lesion induced by Leishmania major infection
    Cindy Allenbach
    WHO Immunology Research and Training Center, Department of Biochemistry, University of Lausanne, Epalinges, Switzerland
    Eur J Immunol 38:720-31. 2008
    b>TNF is an essential player in infections with Leishmania major, contributing to the control of the inflammatory lesion and, to a lesser degree, to parasite killing...
  22. pmc Inhibition of soluble TNF signaling in a mouse model of Alzheimer's disease prevents pre-plaque amyloid-associated neuropathology
    Fiona E McAlpine
    Department of Physiology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9040, USA
    Neurobiol Dis 34:163-77. 2009
    ..Elevated levels of the pro-inflammatory cytokine tumor necrosis factor (TNF) have been reported in serum and post-mortem brains of patients with AD, but its role in progression ..
  23. pmc Transmembrane TNF-alpha: structure, function and interaction with anti-TNF agents
    Takahiko Horiuchi
    Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
    Rheumatology (Oxford) 49:1215-28. 2010
    Transmembrane TNF-alpha, a precursor of the soluble form of TNF-alpha, is expressed on activated macrophages and lymphocytes as well as other cell types...
  24. pmc Expression of a tumor necrosis factor-alpha transgene in murine lung causes lymphocytic and fibrosing alveolitis. A mouse model of progressive pulmonary fibrosis
    Y Miyazaki
    Department of Pathology, University of Geneva, Switzerland
    J Clin Invest 96:250-9. 1995
    The murine TNF-alpha gene was expressed under the control of the human surfactant protein SP-C promoter in transgenic mice. A number of the SP-C TNF-alpha mice died at birth or after a few weeks with very severe lung lesions...
  25. ncbi Structural deficiencies in granuloma formation in TNF gene-targeted mice underlie the heightened susceptibility to aerosol Mycobacterium tuberculosis infection, which is not compensated for by lymphotoxin
    A G Bean
    Centenary Institute of Cancer Medicine and Cell Biology, Newtown, Australia
    J Immunol 162:3504-11. 1999
    b>TNF and lymphotoxin-alpha (LT alpha) may act at various stages of the host response to Mycobacterium tuberculosis...
  26. pmc Interferon gamma contributes to initiation of uterine vascular modification, decidual integrity, and uterine natural killer cell maturation during normal murine pregnancy
    A A Ashkar
    Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada N1G 2W1
    J Exp Med 192:259-70. 2000
    ....
  27. pmc TNF-alpha drives remodeling of blood vessels and lymphatics in sustained airway inflammation in mice
    Peter Baluk
    Cardiovascular Research Institute, Comprehensive Cancer Center, and Department of Anatomy, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
    J Clin Invest 119:2954-64. 2009
    ..Here, we sought to determine whether TNF-alpha drives the changes in blood vessels and lymphatics in M. pulmonis-infected mice...
  28. pmc Mast cells control neutrophil recruitment during T cell-mediated delayed-type hypersensitivity reactions through tumor necrosis factor and macrophage inflammatory protein 2
    T Biedermann
    Department of Dermatology and Allergology, Ludwig Maximilians University Munich, 80337 Munich, Germany
    J Exp Med 192:1441-52. 2000
    ..the skin, we found that mast cells determine the T cell-dependent PMN recruitment through two mediators, tumor necrosis factor (TNF) and the CXC chemokine macrophage inflammatory protein 2 (MIP-2), the functional analogue of human ..
  29. pmc Fatal Mycobacterium tuberculosis infection despite adaptive immune response in the absence of MyD88
    Cecile M Fremond
    CNRS, Molecular Immunology and Embryology, 3B rue de la Ferollerie, 45071 Orleans, France
    J Clin Invest 114:1790-9. 2004
    ..While primary MyD88(-/-) macrophages and DCs are defective in TNF, IL-12, and NO production in response to mycobacterial stimulation, the upregulation of costimulatory molecules ..
  30. ncbi Syntaxin 6 and Vti1b form a novel SNARE complex, which is up-regulated in activated macrophages to facilitate exocytosis of tumor necrosis Factor-alpha
    Rachael Z Murray
    Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia 4072
    J Biol Chem 280:10478-83. 2005
    A key function of activated macrophages is to secrete proinflammatory cytokines such as TNFalpha; however, the intracellular pathway and machinery responsible for cytokine trafficking and secretion is largely undefined...
  31. pmc High tumor necrosis factor alpha (TNF-alpha) production in Trypanosoma cruzi-infected pregnant mice and increased TNF-alpha gene transcription in their offspring
    M T Rivera
    Laboratoire de Parasitologie, Faculte de Medecine, Universite Libre de Bruxelles, Belgium
    Infect Immun 63:591-5. 1995
    Since tumor necrosis factor alpha (TNF-alpha) is known to be involved in the feto-maternal relationship, this cytokine was studied in Trypanosoma cruzi-infected pregnant BALB/c mice and their fetuses and offspring...
  32. pmc Protection by alpha 1-acid glycoprotein against tumor necrosis factor-induced lethality
    C Libert
    Laboratory of Molecular Biology, University of Gent, Belgium
    J Exp Med 180:1571-5. 1994
    ..that alpha 1-acid glycoprotein, a typical acute phase protein, protects mice from lethal shock induced by tumor necrosis factor (TNF) or endotoxin. The protection is observed both in normal and in galactosamine-sensitized mice...
  33. ncbi TNF-alpha- and IFN-gamma-mediated signal transduction pathways: effects on glial cell gene expression and function
    E N Benveniste
    Department of Cell Biology, University of Alabama at Birmingham 35294 0005, USA
    FASEB J 9:1577-84. 1995
    ..This article focuses on the biological role of two cytokines, namely: tumor necrosis factor alpha (TNF-alpha), and interferon-gamma (IFN-gamma), in the progression of neurologic disorders such as ..
  34. ncbi Classic ischemic but not pharmacologic preconditioning is abrogated following genetic ablation of the TNFalpha gene
    Robert M Smith
    Hatter Institute for Cardiology Research, MRC Inter University Cape Heart Group, University of Cape Town Medical School, Observatory 7925, South Africa
    Cardiovasc Res 55:553-60. 2002
    b>Tumor necrosis factor alpha (TNFalpha) is known to mimic ischemic preconditioning (IP). However, it is not known whether TNFalpha-preconditioning is mediated by 'established' preconditioning signaling or via novel signaling cascades...
  35. ncbi Tumor necrosis factor (TNF) ligand and TNF receptor deficiency affects sleep and the sleep EEG
    Tom Deboer
    Institute of Pharmacology and Toxicology, CH 8057, Switzerland
    J Neurophysiol 88:839-46. 2002
    b>Tumor necrosis factor (TNF) and lymphotoxin-alpha (LT-alpha) are proinflammatory cytokines involved in host defense and pathogenesis of various diseases. In addition, there is evidence that TNF is involved in sleep...
  36. ncbi Requirement for tumor necrosis factor-receptor 2 in alveolar chemokine expression depends upon the form of the ligand
    Jun Liu
    Department of Medicine, Yale University School of Medicine, New Haven, Connecticut, USA
    Am J Respir Cell Mol Biol 33:463-9. 2005
    ..antigen recognition by CD8+ T lymphocytes results in significant injury that is critically dependent upon tumor necrosis factor (TNF)-alpha expressed by the CD8+ T cells and is largely dependent upon TNF-receptor 1 expression on the ..
  37. ncbi Epithelial NEMO links innate immunity to chronic intestinal inflammation
    Arianna Nenci
    Institute for Genetics, University of Cologne, Zulpicher Strasse 47, 50674 Cologne, Germany
    Nature 446:557-61. 2007
    ..Furthermore, NEMO deficiency sensitized epithelial cells to tumour-necrosis factor (TNF)-induced apoptosis, whereas TNF receptor-1 inactivation inhibited intestinal inflammation, demonstrating that TNF ..
  38. ncbi Tumor necrosis factor-alpha is toxic via receptor 1 and protective via receptor 2 in a murine model of myocardial infarction
    Yoshiya Monden
    Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, 3 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Am J Physiol Heart Circ Physiol 293:H743-53. 2007
    b>Tumor necrosis factor (TNF)-alpha induced in damaged myocardium has been considered to be cardiotoxic. TNF-alpha initiates its biological effects by binding two distinct receptors: R1 (p55) and R2 (p75)...
  39. doi Anti-tumor necrosis factor therapy inhibits pancreatic tumor growth and metastasis
    Jan Hendrik Egberts
    Division of Molecular Oncology, Department of General Surgery and Thoracic Surgery, University Hospital of Schleswig Holstein, Campus Kiel, Kiel, Germany
    Cancer Res 68:1443-50. 2008
    ..In the present work, we investigated the role of the major proinflammatory cytokine tumor necrosis factor alpha (TNFalpha) in the malignancy of PDAC cells in vitro and in vivo...
  40. doi Microglia protect neurons against ischemia by synthesis of tumor necrosis factor
    Kate Lykke Lambertsen
    Medical Biotechnology Center, University of Southern Denmark, 5000 Odense, Denmark
    J Neurosci 29:1319-30. 2009
    Microglia and infiltrating leukocytes are considered major producers of tumor necrosis factor (TNF), which is a crucial player in cerebral ischemia and brain inflammation...
  41. doi TNF-α/Fas-RIP-1-induced cell death signaling separates murine hematopoietic stem cells/progenitors into 2 distinct populations
    Yechen Xiao
    Oncology Institute, Cardinal Bernardin Cancer Center, Loyola University Medical Center, Maywood, IL 60153, USA
    Blood 118:6057-67. 2011
    We studied the effects of TNF-α and Fas-induced death signaling in hematopoietic stem and progenitor cells (HSPCs) by examining their contributions to the development of bone marrow failure syndromes in Tak1-knockout mice (Tak1(-/-))...
  42. pmc In autoimmune diabetes the transition from benign to pernicious insulitis requires an islet cell response to tumor necrosis factor alpha
    S V Pakala
    Center for Immunology and Department of Pathology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Exp Med 189:1053-62. 1999
    ..Of these, interleukin 1beta, tumor necrosis factor (TNF)-alpha, and interferon (IFN)-gamma are perhaps the most important...
  43. ncbi Role of tumor necrosis factor-alpha in Mycobacterium-induced granuloma formation in tumor necrosis factor-alpha-deficient mice
    H Kaneko
    Department of Molecular Pathology, The Research Institute of Tuberculosis, Kiyose, Tokyo, Japan
    Lab Invest 79:379-86. 1999
    To study the role of TNF-alpha in mycobacterial infection, we generated TNF-alpha-knockout (KO) mice, in which the third and fourth exons of the TNF-alpha gene were disrupted...
  44. ncbi Fatal Mycobacterium bovis BCG infection in TNF-LT-alpha-deficient mice
    M Jacobs
    Department of Immunology, University of Cape Town, Cape Town, South Africa
    Clin Immunol 94:192-9. 2000
    Neutralization of TNF or disruption of TNF-R1 leads to fatal Mycobacterium bovis BCG infection...
  45. pmc Toll-like receptor 2-deficient mice succumb to Mycobacterium tuberculosis infection
    Michael B Drennan
    Department of Immunology, Groote Schuur Hospital, University of Cape Town, Cape Town, South Africa
    Am J Pathol 164:49-57. 2004
    ..TLR2-deficient mice after 500 mycobacterial aerosol challenge showed increased levels of interferon-gamma, tumor necrosis factor-alpha, and interleukin-12p40 as well as increased numbers of CD4(+) and CD8(+) cells...
  46. ncbi Novel anti-inflammatory role for glycogen synthase kinase-3beta in the inhibition of tumor necrosis factor-alpha- and interleukin-1beta-induced inflammatory gene expression
    Angela Vines
    Reddy US Therapeutics, Dr Reddy s Laboratories, Norcross, Georgia 30071, USA
    J Biol Chem 281:16985-90. 2006
    ..We observed that tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) treatment of primary cultures of human microvascular ..
  47. pmc Fatal hepatitis mediated by tumor necrosis factor TNFalpha requires caspase-8 and involves the BH3-only proteins Bid and Bim
    Thomas Kaufmann
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC 3052, Australia
    Immunity 30:56-66. 2009
    ..and acute liver diseases, can be a consequence of overactivation of the immune system and is often mediated by TNFalpha. Injection with lipopolysaccharide (LPS) plus the transcriptional inhibitor D(+)-galactosamine (GalN) or ..
  48. ncbi Dilated cardiomyopathy in transgenic mice with cardiac-specific overexpression of tumor necrosis factor-alpha
    T Kubota
    Cardiovascular Research Laboratories, University of Pittsburgh Medical Center, PA 15213, USA
    Circ Res 81:627-35. 1997
    The failing human heart expresses tumor necrosis factor-alpha (TNF-alpha). However, its pathophysiological significance is not clear...
  49. pmc Interplay of IKK/NF-kappaB signaling in macrophages and myofibers promotes muscle degeneration in Duchenne muscular dystrophy
    Swarnali Acharyya
    Human Cancer Genetics Program and Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University College of Medicine, Columbus, Ohio 43210, USA
    J Clin Invest 117:889-901. 2007
    ..Collectively, these results underscore the critical role of NF-kappaB in the progression of muscular dystrophy and suggest the IKK/NF-kappaB signaling pathway as a potential therapeutic target for DMD...
  50. pmc An essential role for tumor necrosis factor in natural killer cell-mediated tumor rejection in the peritoneum
    M J Smyth
    Cellular Cytotoxicity Laboratory, The Austin Research Institute, Heidelberg, Victoria 3084, Australia
    J Exp Med 188:1611-9. 1998
    ..1(+) cells. Furthermore, we demonstrate that B6 mice lacking tumor necrosis factor (TNF) are also significantly defective in their rejection of RMA-S, despite the fact that RMA-S is ..
  51. pmc Critical roles for interleukin 1 and tumor necrosis factor alpha in antibody-induced arthritis
    Hong Ji
    Section on Immunology and Immunogenetics, Joslin Diabetes Center and Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    J Exp Med 196:77-85. 2002
    ..Interleukin (IL)-1 proved absolutely necessary. Tumor necrosis factor (TNF)-alpha was also required, although seemingly less critically than IL-1, because a proportion of TNF-..
  52. ncbi Rapid production of TNF-alpha following TCR engagement of naive CD8 T cells
    Michael A Brehm
    Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Immunol 175:5043-9. 2005
    ..cells are capable of immediate effector function following TCR engagement, which stimulates the rapid production of TNF-alpha...
  53. pmc TNF-alpha is critical for antitumor but not antiviral T cell immunity in mice
    Thomas Calzascia
    The Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, Toronto, Ontario, Canada
    J Clin Invest 117:3833-45. 2007
    b>TNF-alpha antagonists are widely used in the treatment of inflammatory and autoimmune diseases, but their use is associated with reactivation of latent infections...
  54. doi TPL2-mediated activation of ERK1 and ERK2 regulates the processing of pre-TNF alpha in LPS-stimulated macrophages
    Simon Rousseau
    MRC Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dow Street, Dundee, DD1 5EH, UK
    J Cell Sci 121:149-54. 2008
    ..of the TPL2-MKK1/2-ERK1/2 signalling pathway is essential for lipopolysaccharide (LPS)-stimulated production of TNF alpha in macrophages...
  55. doi Down-regulation of the de-ubiquitinating enzyme ubiquitin-specific protease 2 contributes to tumor necrosis factor-alpha-induced hepatocyte survival
    Florian Haimerl
    Institute of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen Nuremberg, Erlangen D 91054, Germany
    J Biol Chem 284:495-504. 2009
    b>Tumor necrosis factor-alpha (TNFalpha) stimulation of hepatocytes induces either cell survival or apoptosis, which seems to be regulated by the ubiquitin-proteasome system...
  56. doi Ischaemic postconditioning protects against reperfusion injury via the SAFE pathway
    Lydia Lacerda
    Hatter Cardiovascular Research Institute, Cardioprotection Group, Department of Medicine, Faculty of Health Sciences, University of Cape Town, Observatory 7925, Cape Town, South Africa
    Cardiovasc Res 84:201-8. 2009
    ..the newly described prosurvival Survivor Activating Factor Enhancement (SAFE) pathway, which involves the activation of the cytokine tumour necrosis factor alpha (TNFalpha) and signal transducer and activator of transcription-3 (STAT-3).
  57. ncbi Membrane-bound TNF supports secondary lymphoid organ structure but is subservient to secreted TNF in driving autoimmune inflammation
    S R Ruuls
    DNAX, 901 California Avenue, Palo Alto, CA 94304, USA
    Immunity 15:533-43. 2001
    Mice without secreted TNF but with functional, normally regulated and expressed membrane-bound TNF (memTNF(Delta/Delta) mice) were created by knocking-in the uncleavable Delta 1-9,K11E TNF allele...
  58. pmc Mast cells modulate the pathogenesis of elastase-induced abdominal aortic aneurysms in mice
    Jiusong Sun
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 117:3359-68. 2007
    ..Reconstitution of KitW-sh/KitW-sh mice with bone marrow-derived mast cells from WT or TNF-alpha-/- mice, but not from IL-6-/- or IFN-gamma-/- mice, caused susceptibility to AAA formation to be regained...
  59. ncbi TNF alpha promotes proliferation of oligodendrocyte progenitors and remyelination
    H A Arnett
    Lineberger Comprehensive Cancer Center, School of Medicine CB7295, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Nat Neurosci 4:1116-22. 2001
    Here we used mice lacking tumor necrosis factor-alpha (TNF alpha) and its associated receptors to study a model of demyelination and remyelination in which these events could be carefully controlled using a toxin, cuprizone...
  60. pmc Up-regulation of TNF-producing T cells in the bone marrow: a key mechanism by which estrogen deficiency induces bone loss in vivo
    C Roggia
    Division of Bone and Mineral Diseases, Washington University School of Medicine and Barnes Jewish Hospital, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 98:13960-5. 2001
    ..In vitro, T cells from ovariectomized mice produce increased amounts of tumor necrosis factor (TNF), which augments receptor activator of NF-kappa B ligand (RANKL)-induced osteoclastogenesis...
  61. ncbi Neurodegenerative and neuroprotective effects of tumor Necrosis factor (TNF) in retinal ischemia: opposite roles of TNF receptor 1 and TNF receptor 2
    Valerie Fontaine
    Institute of Cell Biology and Immunology, University of Stuttgart, 70569 Stuttgart, Germany
    J Neurosci 22:RC216. 2002
    b>Tumor necrosis factor (TNF) is an important factor in various acute and chronic neurodegenerative disorders...
  62. ncbi Ferritin heavy chain upregulation by NF-kappaB inhibits TNFalpha-induced apoptosis by suppressing reactive oxygen species
    Can G Pham
    The Ben May Institute for Cancer Research and The University of Chicago, 924 East 57th Street, Chicago, IL 60637, USA
    Cell 119:529-42. 2004
    During inflammation, NF-kappaB transcription factors antagonize apoptosis induced by tumor necrosis factor (TNF)alpha...
  63. pmc Sleep-wake behavior and responses to sleep deprivation of mice lacking both interleukin-1 beta receptor 1 and tumor necrosis factor-alpha receptor 1
    Francesca Baracchi
    Department of Anesthesiology, University of Michigan, 7422 Medical Sciences Building I, 1150 W Medical Center Drive, Ann Arbor, MI 48109 5615, USA
    Brain Behav Immun 22:982-93. 2008
    Data indicate that interleukin (IL)-1 beta and tumor necrosis factor-alpha (TNFalpha) are involved in the regulation of non-rapid eye movement sleep (NREMS)...
  64. pmc Ectodomain shedding of EGFR ligands and TNFR1 dictates hepatocyte apoptosis during fulminant hepatitis in mice
    Aditya Murthy
    Ontario Cancer Institute, Toronto, Ontario, Canada
    J Clin Invest 120:2731-44. 2010
    ..ADAM17, and ADAM17-regulated cell surface molecules, we have found that ADAM17-mediated ectodomain shedding of TNF receptors and EGF family ligands controls activation of multiple signaling cascades in Fas-induced hepatitis...
  65. ncbi Distinct roles for lymphotoxin-alpha and tumor necrosis factor in organogenesis and spatial organization of lymphoid tissue
    H Korner
    Centenary Institute of Cancer Medicine and Cell Biology, Sydney, Australia
    Eur J Immunol 27:2600-9. 1997
    Specialized roles for the pro-inflammatory cytokines tumor necrosis factor (TNF) and lymphotoxin (LT) were characterized in TNF/LT alpha -/- and TNF -/- mice established by direct gene targeting of C57BL/6 ES cells...
  66. ncbi TNF accelerates the onset but does not alter the incidence and severity of myelin basic protein-induced experimental autoimmune encephalomyelitis
    G Kassiotis
    Laboratory of Molecular Genetics, Hellenic Pasteur Institute, Athens, Greece
    Eur J Immunol 29:774-80. 1999
    Experimental autoimmune encephalomyelitis (EAE) induction in TNF gene-targeted mice has resulted in conflicting reports in part due to the strong association of TNF with the MHC locus...
  67. ncbi Oestrogen and progesterone reduce lipopolysaccharide-induced expression of tumour necrosis factor-alpha and interleukin-18 in midbrain astrocytes
    M Kipp
    Institute of Neuroanatomy, RWTH Aachen, Aachen, Germany
    J Neuroendocrinol 19:819-22. 2007
    ..investigated the influence of oestrogen and progesterone on the expression of the cytokines tumour necrosis factor (TNF)-alpha and interleukin (IL)-18 in primary astrocytes obtained from neonatal mouse midbrain and cerebral cortex ..
  68. doi Tumor necrosis factor alpha enhances glutamatergic transmission onto spinal motoneurons
    Pengcheng Han
    Hotchkiss Brain Institute, Department of Comparative Biology and Experimental Medicine, University of Calgary, Calgary, Alberta, Canada
    J Neurotrauma 27:287-92. 2010
    ..However, glutamate release is not the only factor to consider. Inflammatory molecules like tumor necrosis factor alpha (TNFalpha), belonging to a group of cytokines initially identified and named for their ability to kill ..
  69. doi Tumor necrosis factor α sensitizes primary murine hepatocytes to Fas/CD95-induced apoptosis in a Bim- and Bid-dependent manner
    Kathrin Schmich
    Department of Pharmaceutical Biology and Biotechnology, Albert Ludwigs University of Freiburg, Freiburg, Germany
    Hepatology 53:282-92. 2011
    ..In contrast, the proinflammatory cytokine tumor necrosis factor α (TNFα) fails to provoke cell death in isolated hepatocytes but has been implicated in hepatocyte ..
  70. pmc Oligodendrocyte apoptosis and primary demyelination induced by local TNF/p55TNF receptor signaling in the central nervous system of transgenic mice: models for multiple sclerosis with primary oligodendrogliopathy
    K Akassoglou
    Department of Molecular Genetics, Hellenic Pasteur Institute, Athens, Greece
    Am J Pathol 153:801-13. 1998
    ..To evaluate the contribution of local tumor necrosis factor (TNF) ligand/receptor signaling pathways to MS immunopathogenesis we have analyzed disease pathology in ..
  71. pmc TNF-alpha mediated apoptosis plays an important role in the development of early diabetic retinopathy and long-term histopathological alterations
    Antonia M Joussen
    Department of Ophthalmology, Heinrich Heine University, Duesseldorf, Germany
    Mol Vis 15:1418-28. 2009
    ..We investigated the involvement of tumor necrosis factor alpha (TNF-alpha) in diabetes-related histopathological changes in two relevant rodent models.
  72. ncbi A novel form of TNF/cachectin is a cell surface cytotoxic transmembrane protein: ramifications for the complex physiology of TNF
    M Kriegler
    Department of Molecular Biology, Cetus Corporation, Emeryville, California 94608
    Cell 53:45-53. 1988
    b>Tumor necrosis factor (TNF) is a monocyte-derived cytotoxin that has been implicated in tumor regression, septic shock, and cachexia. The mechanism by which TNF induces these different disease states is unclear...
  73. ncbi The type I interleukin-1 receptor acts in series with tumor necrosis factor (TNF) to induce arthritis in TNF-transgenic mice
    L Probert
    Department of Molecular Genetics, Hellenic Pasteur Institute, Athens, Greece
    Eur J Immunol 25:1794-7. 1995
    The pro-inflammatory cytokines tumor necrosis factor (TNF) and interleukin-1 (IL-1) have been shown to be primary mediators in the pathogenesis of chronic inflammatory joint diseases...
  74. pmc Effect of tumor necrosis factor alpha on insulin-dependent diabetes mellitus in NOD mice. I. The early development of autoimmunity and the diabetogenic process
    X D Yang
    Department of Microbiology, Stanford University School of Medicine, California 94305
    J Exp Med 180:995-1004. 1994
    b>Tumor necrosis factor (TNF) alpha is a cytokine that has potent immune regulatory functions...
  75. ncbi Control of established experimental allergic encephalomyelitis by inhibition of tumor necrosis factor (TNF) activity within the central nervous system using monoclonal antibodies and TNF receptor-immunoglobulin fusion proteins
    D Baker
    Department of Pathology, Royal College of Surgeons of England, London
    Eur J Immunol 24:2040-8. 1994
    b>Tumor necrosis factor (TNF) activity was inhibited during the development of actively-induced, chronic relapsing experimental allergic encephalomyelitis (CREAE) in Biozzi AB/H mice, using a mouse TNF-specific (TN3.19...
  76. ncbi Unraveling function in the TNF ligand and receptor families
    B Beutler
    Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas 75235 9050
    Science 264:667-8. 1994
  77. pmc Defective Peyer's patch organogenesis in mice lacking the 55-kD receptor for tumor necrosis factor
    B Neumann
    Institute for Medical Microbiology and Hygiene, Technical University of Munich, Germany
    J Exp Med 184:259-64. 1996
    Lymphotoxin alpha (LT-alpha) may form secreted homotrimers binding to p55 and p75 tumor necrosis factor (TNF) receptors or cell surface-bound heterotrimers with LT-beta that interact with the LT-beta receptor...
  78. ncbi Predominant pathogenic role of tumor necrosis factor in experimental colitis in mice
    M F Neurath
    Laboratory of Immunology, I Medical Clinic, University of Mainz, Germany
    Eur J Immunol 27:1743-50. 1997
    Antibodies to tumor necrosis factor (TNF)-alpha have been recently proposed as effective treatment for patients with Crohn's disease...
  79. ncbi A murine transmembrane tumor necrosis factor (TNF) transgene induces arthritis by cooperative p55/p75 TNF receptor signaling
    L Alexopoulou
    Department of Molecular Genetics, Hellenic Pasteur Institute, Athens, Greece
    Eur J Immunol 27:2588-92. 1997
    The arthritogenic activities of tumor necrosis factor (TNF) and its p55TNF-receptor (R) have been well documented in experimental animal models of arthritis, and in transgenic mice expressing wild-type or mutant transmembrane human TNF ..
  80. pmc Lymphotoxin alpha/beta and tumor necrosis factor are required for stromal cell expression of homing chemokines in B and T cell areas of the spleen
    V N Ngo
    Department of Microbiology and Immunology, University of California San Francisco, San Francisco, California 94143, USA
    J Exp Med 189:403-12. 1999
    Mice deficient in the cytokines tumor necrosis factor (TNF) or lymphotoxin (LT) alpha/beta lack polarized B cell follicles in the spleen...
  81. ncbi TNF and lymphotoxin beta cooperate in the maintenance of secondary lymphoid tissue microarchitecture but not in the development of lymph nodes
    D V Kuprash
    Laboratory of Molecular Immunology, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow State University, Russia
    J Immunol 163:6575-80. 1999
    Inactivation of genes encoding members of TNF and TNF receptor families reveal their divergent roles in the formation and function of secondary lymphoid organs...
  82. ncbi Transmembrane TNF induces an efficient cell-mediated immunity and resistance to Mycobacterium bovis bacillus Calmette-Guérin infection in the absence of secreted TNF and lymphotoxin-alpha
    Maria L Olleros
    Department of Pathology, University of Geneva, Geneva, Switzerland
    J Immunol 168:3394-401. 2002
    The contribution of a transmembrane (Tm) form of TNF to protective immunity against Mycobacterium bovis bacillus Calmette-Guérin (BCG) was studied in transgenic (tg) mice expressing a noncleavable Tm TNF but lacking the TNF/lymphotoxin-..
  83. pmc Lack of tumor necrosis factor alpha induces impaired proliferation of hepatitis B virus-specific cytotoxic T lymphocytes
    Senji Kasahara
    First Department of Internal Medicine, Gifu University School of Medicine, 40 Tsukasa Machi, Gifu 500 8705, Japan
    J Virol 77:2469-76. 2003
    Recent studies have shown that tumor necrosis factor alpha (TNF-alpha) plays critical roles in not only viral clearance but also lymphoid tissue development and stem cell differentiation...
  84. ncbi JunD mediates survival signaling by the JNK signal transduction pathway
    Jennifer A Lamb
    Howard Hughes Medical Institute and Program in Molecular Medicine, Department of Biochemistry and Molecular Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Mol Cell 11:1479-89. 2003
    ..Furthermore, these data illustrate the general principal that signal transduction pathway integration is critical for the ability of cells to mount an appropriate biological response to a specific challenge...
  85. ncbi Systemic tumor necrosis factor alpha mediates an increase in peripheral CD11bhigh osteoclast precursors in tumor necrosis factor alpha-transgenic mice
    Ping Li
    University of Rochester Medical Center, Rochester, New York 14642, USA
    Arthritis Rheum 50:265-76. 2004
    To investigate the mechanisms whereby tumor necrosis factor alpha (TNFalpha) increases osteoclastogenesis in vivo.
  86. pmc TNF-alpha regulates myogenesis and muscle regeneration by activating p38 MAPK
    Shuen Ei Chen
    Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    Am J Physiol Cell Physiol 292:C1660-71. 2007
    ..reported that p38 activation, myogenesis, and regeneration in cardiotoxin-injured soleus muscle are impaired in TNF-alpha receptor double-knockout (p55(-/-)p75(-/-)) mice...
  87. pmc Tumour necrosis factor-alpha inhibits adipogenesis via a beta-catenin/TCF4(TCF7L2)-dependent pathway
    W P Cawthorn
    Department of Clinical Biochemistry, Addenbrooke s Hospital, University of Cambridge, Cambridge, UK
    Cell Death Differ 14:1361-73. 2007
    Tumour necrosis factor-alpha (TNF-alpha), a proinflammatory cytokine, is a potent negative regulator of adipocyte differentiation. However, the mechanism of TNF-alpha-mediated antiadipogenesis remains incompletely understood...
  88. doi Physiological functions of tumor necrosis factor and the consequences of its pathologic overexpression or blockade: mouse models
    Andrei A Kruglov
    Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Vavilov Street 32, Moscow 119991, Russia
    Cytokine Growth Factor Rev 19:231-44. 2008
    b>TNF is an exciting cytokine which has helped to establish many paradigms in immunology...
  89. ncbi Synthesis and granular localization of tumor necrosis factor-alpha in activated NK cells in the pregnant mouse uterus
    E L Parr
    Department of Anatomy, Southern Illinois University School of Medicine, Carbondale 62901, USA
    J Reprod Immunol 28:31-40. 1995
    The synthesis and cellular localization of tumor necrosis factor-alpha (TNF-alpha) were studied in mouse GMG cells, which are activated NK cells in uterine decidual tissue during pregnancy...
  90. pmc TNF-alpha mediates chemokine and cytokine expression and renal injury in cisplatin nephrotoxicity
    Ganesan Ramesh
    Division of Nephrology, Penn State College of Medicine, Milton S Hershey Medical Center, Hershey, Pennsylvania 17033, USA
    J Clin Invest 110:835-42. 2002
    ..We found significant upregulation of TNF-alpha, TGF-beta, RANTES, MIP-2, MCP-1, TCA3, IL-1beta, and ICAM-1 in kidneys from cisplatin-treated animals...
  91. ncbi The p55 TNF receptor mediates TNF inhibition of osteoblast differentiation independently of apoptosis
    Linda C Gilbert
    Division of Endocrinology and Metabolism, Department of Medicine, Emory University School of Medicine and Veterans Affairs Medical Center, GA 30033, USA
    Am J Physiol Endocrinol Metab 288:E1011-8. 2005
    After menopause, increased tumor necrosis factor-alpha (TNF-alpha) stimulates bone resorption while inhibiting differentiation of new bone-forming osteoblasts (OB)...
  92. ncbi Roles for C16-ceramide and sphingosine 1-phosphate in regulating hepatocyte apoptosis in response to tumor necrosis factor-alpha
    Yosuke Osawa
    Department of Medicine, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
    J Biol Chem 280:27879-87. 2005
    b>Tumor necrosis factor (TNF)-alpha signals cell death and simultaneously induces the generation of ceramide, which is metabolized to sphingosine and sphingosine 1-phosphate (S1P) by ceramidase (CDase) and sphingosine kinase...
  93. ncbi Aggravation of experimental autoimmune neuritis in TNF-alpha receptor 1 deficient mice
    Ming Ou Lu
    Division of Neurodegeneration and Neuroinflammation, Karolinska Institute, Karolinska University Hospital Huddinge, Stockholm, Sweden
    J Neuroimmunol 186:19-26. 2007
    The role of tumor necrosis factor (TNF)-alpha and its receptors in the pathogenesis of experimental autoimmune neuritis (EAN) induced by P0 peptide 180-199 in TNFR1 (p55) deficient (TNFR1-/-) mice was investigated...
  94. pmc Demonstration of inflammation-induced cancer and cancer immunoediting during primary tumorigenesis
    Jeremy B Swann
    Cancer Immunology Program, Trescowthick Laboratories, Peter MacCallum Cancer Centre, St Andrews Place, East Melbourne, Victoria 3002, Australia
    Proc Natl Acad Sci U S A 105:652-6. 2008
    ..Despite the reported role of TNF in chronic inflammation, TNF-deficient mice were significantly more susceptible to MCA-induced sarcoma than WT mice...
  95. pmc Ascorbic acid pre-treated quartz stimulates TNF-alpha release in RAW 264.7 murine macrophages through ROS production and membrane lipid peroxidation
    Sonia Scarfi
    Department of Experimental Medicine, Section of Biochemistry, University of Genova, Genova, Italy
    Respir Res 10:25. 2009
    ..7...
  96. doi FADD prevents RIP3-mediated epithelial cell necrosis and chronic intestinal inflammation
    Patrick Simon Welz
    Institute for Genetics, Centre for Molecular Medicine, University of Cologne, Zülpicher Str 47a, 50674 Cologne, Germany
    Nature 477:330-4. 2011
    ..In FADD(IEC-KO) mice, TNF deficiency ameliorated colon inflammation, whereas MYD88 deficiency and also elimination of the microbiota ..
  97. ncbi Cachectin and tumour necrosis factor as two sides of the same biological coin
    B Beutler
    Nature 320:584-8. 1986
    In response to invasive stimuli macrophages secrete cachectin, a multipotent protein. Prominent among its biological effects is the ability to induce wasting (cachexia) as well as a lethal state of shock...
  98. ncbi Generation and biological characterization of membrane-bound, uncleavable murine tumor necrosis factor
    E Decoster
    Laboratory of Molecular Biology, Gent University, Belgium
    J Biol Chem 270:18473-8. 1995
    b>Tumor necrosis factor (TNF) is produced as a membrane-bound, 26-kDa proform from which the mature, 17-kDa TNF subunit is released by proteolytic cleavage...
  99. ncbi TNF-alpha inhibits the further development of committed progenitors while stimulating multipotential progenitors in mouse long-term bone marrow cultures
    J A Rogers
    Department of Pathology, Albert Einstein College of Medicine, Bronx, NY 10461
    J Immunol 153:4694-703. 1994
    We studied simultaneously the effect of TNF on both relatively primitive and more mature hematopoietic progenitors by using a modification of the mouse long-term bone marrow culture system of Dexter...
  100. ncbi Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection
    K Pfeffer
    Department of Medical Biophysics, University of Toronto, Princess Margaret Hospital, Canada
    Cell 73:457-67. 1993
    The multiple biological activities of tumor necrosis factor (TNF) are mediated by two distinct cell surface receptors of 55 kd (TNFRp55) and 75 kd (TNFRp75). Using gene targeting, we generated a TNFRp55-deficient mouse strain...
  101. ncbi Astrocyte-specific but not neuron-specific transmembrane TNF triggers inflammation and degeneration in the central nervous system of transgenic mice
    K Akassoglou
    Department of Molecular Genetics, Hellenic Pasteur Institute, Athens, Greece
    J Immunol 158:438-45. 1997
    To study the involvement of TNF in cerebral pathology in vivo and to define cellular interactions within the central nervous system (CNS) that promote TNF signaling, we have expressed this cytokine either as a wild-type or a mutant ..

Research Grants60

  1. Defending Against Systemic Mycoses
    GEORGE DEEPE; Fiscal Year: 2008
    ..The collaborative and synergistic effort manifested by this group of investigators will provide new and exciting information regarding prevention and/or treatment of these problematic fungi. ..
  2. PROTECTIVE ANTIGENS FROM HISTOPLASMA CAPSULATUM
    GEORGE DEEPE; Fiscal Year: 2007
    ..that effect of rhsp 60 as vaccine persists for >_3 months and sustaining its durability requires tumor necrosis factor (TNF)-c_ and granulocyte-macrophage colony stimulating factor (GM-CSF) but not interleukins-10 or -12 or ..
  3. Zinc inhibition of endotoxemia in alcoholic liver injury
    Zhanxiang Zhou; Fiscal Year: 2010
    ..The results would have high potential leading to a simplistic approach to prevention/treatment of ALD. ..
  4. Zinc and Alcohol-Induced Oxidative Liver Injury
    Zhanxiang Zhou; Fiscal Year: 2009
    ..These studies will provide fundamental understanding of the role of zinc in the pathophysiology of ALD, and pave the way to novel therapeutical approaches to prevention and treatment of this disease. ..
  5. CD4+ T CELLS PROMOTE EARLY ATHEROSCLEROSIS
    Sally Huber; Fiscal Year: 2002
    ..T cells can be categorized by the types of cytokines they produce. Th1 cells make IFN, IL-2 and TNF, whereas Th2 cells make IL-4, IL-6, and IL-10...
  6. T reg Cells in Myocarditis
    Sally A Huber; Fiscal Year: 2010
    ..A major difference in H3 and H310A1 infections is that H3 virus is a potent inducer of systemic TNFa while H310A1 infection induces little of this cytokine...
  7. Sex in Viral Myocarditis
    Sally Huber; Fiscal Year: 2004
    ..These studies may provide new insights as to how viruses affect developing host defense responses and how hormones can modulate this initial response. ..
  8. Metallothionein in Chronic Alcoholic Liver Injury
    Zhanxiang Zhou; Fiscal Year: 2004
    ..These studies will provide fundamental understanding of the role and possible clinical application of MT in cytoprotection against chronic alcohol-induced liver injury, a major clinical health problem without FDA approved therapy. ..
  9. Sex in Myocarditis
    Sally Huber; Fiscal Year: 2008
    ..Estrogen suppresses systemic tumor necrosis factor-alpha (TNFa) responses which may explain the reduced pathogenicity of CVB3 in this sex...
  10. CDI and Gamma Delta+ in Viral Myocarditis
    Sally Huber; Fiscal Year: 2005
    ..abstract_text> ..
  11. Transport of TNFalpha across the BBB
    Weihong Pan; Fiscal Year: 2008
    ..static or physically passive, but undergoes dynamic changes, to regulate the availability of the cytokine tumor necrosis factor a (TNFa) from blood to the CNS...
  12. T Cell Response to Dengue Virus
    Sujan Shresta; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  13. Induction of immunological paralysis by CpG DNA
    Ae Kyung Yi; Fiscal Year: 2008
    ..abstract_text> ..
  14. 2008 Biology of Acute Respiratory Infections Gordon Research Conference
    JOSEPH MIZGERD; Fiscal Year: 2007
    ..End of Abstract) [unreadable] [unreadable] [unreadable]..
  15. Role of Macrophage Arginase in Anti-Bacterial Immunity
    Peter Murray; Fiscal Year: 2009
    ..The outcomes of the proposed studies will reveal new elements of Arg I function and provide rationale for approaching Arg I as a target in inflammatory diseases. ..
  16. FASEB Summer Conference on: The Biology of Calpains in Health and Disease
    Melissa Spencer; Fiscal Year: 2007
    ..The proposed program will provide the forum by which the momentum in this field may be maintained. [unreadable] [unreadable] [unreadable] [unreadable]..
  17. Proteasomal regulation of TNF-mediated local bone loss
    Lianping Xing; Fiscal Year: 2007
    ..bone loss that is largely due to the effects of increased production of pro-inflammatory cytokines, IL-1, IL-6, and TNF. These cytokines cause enhanced osteoclastogenesis, and reduced osteoblast activity and survival...
  18. Mast Cells and IBD Pathogenesis
    LAURA HALE; Fiscal Year: 2007
    ..They are unique among inflammatory cells in their ability to release pre-stored TNF when stimulated in addition to de novo cytokine production...
  19. Neoadjuvant Cytokine Immunotherapy by PLA Microspheres
    Michael Sabel; Fiscal Year: 2007
    ..I will pursue this area of investigation as a full-time faculty member, with full commitment from the Department of General Surgery and the Division of Surgical Oncology at the University of Michigan Medical Center. ..
  20. Role of prohibitin in intestinal inflammation
    ARIANNE THEISS; Fiscal Year: 2008
    ..Thus, studies on PHB will lead to a better understanding of inflammation-induced oxidative stress and may lead to novel therapies for intestinal inflammatory disorders. [unreadable] [unreadable] [unreadable]..
  21. Matrix metalloproteinases as biomarkers of neurodegeneration
    Veronica Shubayev; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  22. IMMUNE PROMOTION OF REMYELINATION
    Moses Rodriguez; Fiscal Year: 2008
    ..Our findings are expected to provide new insights into the enhancement of remyelination in diseases such as multiple sclerosis. [unreadable] [unreadable]..
  23. Differential Processing/Activation of HSF1 During Fever
    Ishwar Singh; Fiscal Year: 2007
    ..Our previous studies support a central role for HSF1 as the central mediator of FRT-induced tumor necrosis factor alpha gene repression...
  24. DIETARY LIPIDS AND EXPERIMENTAL IGA NEPHROPATHY
    James Pestka; Fiscal Year: 2009
    ..abstract_text> ..
  25. Cell Cycle Inhibition in Systemic Autoimmunity
    DWIGHT KONO; Fiscal Year: 2009
    ..These studies should yield important new insights into the significance and role of p21 in systemic autoimmunity and in host response to foreign antigens. ..
  26. PATHOGENESIS OF MURINE SYSTEMIC LUPUS ERYTHEMATOSUS
    DWIGHT KONO; Fiscal Year: 2009
    ..Identification of the susceptibility genes and elucidation of their roles in the induction of lupus should provide significant insights into the etiopathogenesis of genetically-determined autoimmune diseases. ..
  27. T cell Function in Murine Model of Multiple Sclerosis
    Moses Rodriguez; Fiscal Year: 2010
    ..The findings are expected to provide new insights into the pathogenesis of axonal and neuronal injury in demyelinating disorders such as multiple sclerosis. ..
  28. Mechanisms of Reperfusion-induced Endothelial Injury
    Cuihua Zhang; Fiscal Year: 2010
    ..We propose that endothelial dysfunction during myocardial I/R injury is caused by over-expression of tumor necrosis factor-alpha (TNF-alpha)...
  29. Prevent HIV protease inhibitor-induced atherosclerosis by Berberine
    HUIPING ROSE ZHOU; Fiscal Year: 2010
    ..studies also indicate that BBR strongly inhibits HIV Pi-induced UPR activation, foam cell formation, and TNF-a and IL-6 release in macrophages...
  30. Glial Interactions in Premyelinating Oligodendrocyte Destruction
    Jianrong Li; Fiscal Year: 2010
    ..from a peroxynitrite- dependent mechanism to a mechanism dependent upon the proinflammatory cytokine, tumor necrosis factor 1 (TNF1)...
  31. Chemoprevention of IBD-Associated Colon Cancer
    Laura P Hale; Fiscal Year: 2010
    ..The proposed studies will further elucidate mechanisms that can lead to novel interventions to prevent IBD-associated colon cancers, providing great benefit to IBD patients and their families. ..
  32. Epo-dependent JAK2 Signaling in Painful Neuropathy
    WENDY CAMPANA; Fiscal Year: 2006
    ..The experiments will provide new information on the basic mechanisms of nerve injury and pain, and there from, new rationale for development of novel neuroprotective strategies for preventing chronic neuropathic pain. ..
  33. TUMOR NECROSIS FACTOR INVOLVEMENT IN FUMONISIN TOXICITY
    RAGHUBIR SHARMA; Fiscal Year: 2001
    ..B1 produced apoptotic cells in liver and kidney, the effect was associated with increased production of tumor necrosis factor-alpha (TNF) by systemic macrophages...
  34. HYDROXYNONENAL MODIFICATION OF SUPEROXIDE DISMUTASE
    Kenneth Hensley; Fiscal Year: 2002
    ..abstract_text> ..
  35. ENDOTOXIN AND SUSCEPTIBILITY TO TRICHOTHECENE MYCOTOXINS
    James Pestka; Fiscal Year: 2002
    ..of mice to small doses of LPS and the trichothecene vomitoxin (VT), mRNA expression and serum concentrations of TNF-alpha are greatly elevated as compared to mice receiving LPS or VT alone...
  36. MEDIATORS OF BLOOD-RETINAL BARRIER BREAKDOWN
    STANLEY VINORES; Fiscal Year: 2002
    ....
  37. ROLE OF PKD IN LEUKOCYTE ACTIVATION BY CPG DNA
    Ae Kyung Yi; Fiscal Year: 2002
    ..CpG motifs in bacterial DNA (CpG DNA) induce leukocytes to produce various cytokines such as TNF-a, IL-6, and IL-12, which have been implicated in arthritis...
  38. Role of SOCS proteins in host-pathogen responses
    Peter Murray; Fiscal Year: 2003
    ..PERFORMANCE SITE (S) (organization, city, state) St. Jude Children's Research Hospital, Memphis, TN . ..
  39. Magnesium Deficiency: Effect on Bone and Mineral
    Robert Rude; Fiscal Year: 2004
    ..We will therefore measure serum substance P, TNFalpha, IL1beta, and IL6 in the Mg deficient rat and perform immunohistochemical staining of bone for these cytokines...
  40. NEUTROPHIL RECRUITMENT IN LPS-INDUCED AIRWAY DISEASE
    Jessica Moreland; Fiscal Year: 2004
    ....
  41. Heavy Metal-Induced Autoimmunity
    DWIGHT KONO; Fiscal Year: 2005
    ....
  42. Role of cytokines in retroviral neuropathogenesis
    Karin Peterson; Fiscal Year: 2005
    ..Increased expression of several host genes, including the proinflammatory cytokine TNF alpha and chemokines MCP-1, MIP-1 alpha, MIP-1 beta, and RANTES, have been shown to correlate with neurological ..
  43. Mechanisms of Energy Balance in the Adipocyte
    Richard Bradley; Fiscal Year: 2005
    ..abstract_text> ..
  44. Bromelain as a Biologically-Based Therapy for IBD
    LAURA HALE; Fiscal Year: 2005
    ..This research will thus strengthen the biomedical research knowledge base needed to inform the practice of complementary and alternative medicine. ..
  45. Novel Oral Adjuvant for Dental Vaccines
    LAURA HALE; Fiscal Year: 2005
    ..abstract_text> ..
  46. Modulation of intestinal inflammation by A2b receptor
    Vasantha Kolachala; Fiscal Year: 2007
    ..In the second specific aim, the effect of Th-1 cytokines, IFN-gamma and TNF-alpha, on the regulation of A2bR expression, trafficking and signaling will be studied...
  47. Monocyte Biology and Biodefense
    DOUGLAS DREVETS; Fiscal Year: 2005
    ..These data will then catalyze development of rational therapies to improve host defenses against severe and overwhelming infection by category A and B intracellular bacterial pathogens. ..
  48. Bromelain Proteinase Activity in IBD
    LAURA HALE; Fiscal Year: 2006
    ..They will thus strengthen the scientific knowledge base needed to inform the practice of complementary and alternative medicine. ..
  49. Tolerance Induction for Primate Islet Transplantation
    Maria Koulmanda; Fiscal Year: 2006
    ..abstract_text> ..
  50. ORPHAN NUCLEAR RORgammat IN THYMOCYTE DIFFERENTIATION
    You Wen He; Fiscal Year: 2006
    ..In addition, results from this application will also provide insights for the role of ROR-gamma-t in tumorigenesis. ..
  51. THERAPEUTIC APPROACHES FOR MUSCULAR DYSTROPHY
    Melissa Spencer; Fiscal Year: 2006
    ..Collectively, these findings can provide the basis for design of immune interventions to reduce the pathology of dystrophin deficient muscle. ..
  52. Extracellular Matrix Protein in Innate Immunity
    You Wen He; Fiscal Year: 2007
    ..Results from this proposal will provide novel insights on the mechanisms of the innate immune response and may have implication for clinical treatment of septic shock and other microbe caused diseases. [unreadable] [unreadable]..
  53. Pattern Recognition Molecule Mindin As Adjuvant
    You Wen He; Fiscal Year: 2007
    ..Third, Mindin fused DNA plasmids will be examined for their efficacy in protecting influenza virus infection. [unreadable] [unreadable]..
  54. Transport of neurotrophic cytokines after spinal cord injury
    Weihong Pan; Fiscal Year: 2007
    ..Understanding the mechanisms of cytokine transport at this regulatory interface would help in the design of new approaches to treat SCI. ..
  55. Role of CIC-3 channels in regulation of cell volume and shape in neutrophils
    Jessica Moreland; Fiscal Year: 2007
    ..The studies proposed will advance our fundamental knowledge of the function of neutrophils in the maintenance of normal immune system function. [unreadable] [unreadable] [unreadable]..
  56. ACUTE RENAL FAILURE--IMPACT OF FLUORINATED ANESTHETICS
    RICHARD ZAGER; Fiscal Year: 2001
    ....
  57. HIV Protease Inhibitors, the Unfolded Protein Response and Atherosclerosis
    Huiping Zhou; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  58. Iron Therapy in Renal Disease: Potential Toxicities
    RICHARD ZAGER; Fiscal Year: 2008
    ..Potential reasons for these differences will be assessed, with the ultimate goal of defining the safest way of administering parenteral irons to renal disease patients. ..