Tmod1

Summary

Gene Symbol: Tmod1
Description: tropomodulin 1
Alias: E-Tmod, Tmod, tropomodulin-1, erythrocyte tropomodulin
Species: mouse

Top Publications

  1. ncbi Cytoplasmic nuclear transfer of the actin-capping protein tropomodulin
    Kimi Y Kong
    Institute for Genetic Medicine and Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    J Biol Chem 279:30856-64. 2004
  2. ncbi Cloning of tropomodulin cDNA and localization of gene transcripts during mouse embryogenesis
    M Ito
    Institute for Genetic Medicine, University of Southern California School of Medicine, Los Angeles 90033
    Dev Biol 167:317-28. 1995
  3. pmc Pointed-end capping by tropomodulin modulates actomyosin crossbridge formation in skeletal muscle fibers
    Julien Ochala
    1Centre of Human and Aerospace Physiological Sciences, School of Biomedical Sciences, King s College London, Rm 3 3, Shepherd s House, Guy s Campus, London SE1 1UL, UK
    FASEB J 28:408-15. 2014
  4. pmc Tropomodulin 1 constrains fiber cell geometry during elongation and maturation in the lens cortex
    Roberta B Nowak
    The Scripps Research Institute, La Jolla, CA 92037, USA
    J Histochem Cytochem 60:414-27. 2012
  5. pmc Cytoplasmic gamma-actin and tropomodulin isoforms link to the sarcoplasmic reticulum in skeletal muscle fibers
    David S Gokhin
    Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Cell Biol 194:105-20. 2011
  6. pmc Tropomodulin 1-null mice have a mild spherocytic elliptocytosis with appearance of tropomodulin 3 in red blood cells and disruption of the membrane skeleton
    Jeannette D Moyer
    The Scripps Research Institute, La Jolla, CA 92037, USA
    Blood 116:2590-9. 2010
  7. pmc Tropomodulin isoforms regulate thin filament pointed-end capping and skeletal muscle physiology
    David S Gokhin
    Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Cell Biol 189:95-109. 2010
  8. pmc Tropomodulin1 is required in the heart but not the yolk sac for mouse embryonic development
    Caroline R McKeown
    The Scripps Research Institute, Department of Cell Biology, La Jolla, CA 92037, USA
    Circ Res 103:1241-8. 2008
  9. ncbi Mouse erythrocyte tropomodulin in the brain reported by lacZ knocked-in downstream from the E1 promoter
    Weijuan Yao
    Department of Bioengineering and Center for Molecular Genetics, University of California, San Diego, La Jolla, CA 92093 0412, USA
    Gene Expr Patterns 8:36-46. 2007
  10. ncbi Disruption in the tropomodulin1 (Tmod1) gene compromises cardiomyocyte development in murine embryonic stem cells by arresting myofibril maturation
    Yasuko Ono
    Department of Cell Biology and Anatomy, University of Arizona, 1501 N Campbell Avenue LSN 455, Tucson, AZ 85724, USA
    Dev Biol 282:336-48. 2005

Scientific Experts

  • Julien Ochala
  • David S Gokhin
  • M A Sussman
  • C A Conley
  • Roberta B Nowak
  • Velia M Fowler
  • Weijuan Yao
  • Caroline R McKeown
  • Lanping Amy Sung
  • Carol C Gregorio
  • Toshikazu Suzuki
  • Xin Chu
  • Malgorzata Boczkowska
  • Catherine Cheng
  • Christopher T Pappas
  • Baiyin Yuan
  • Zhenhua Sui
  • Laurent Guillaud
  • Nancy E Kim
  • Heejei Yoon
  • Jeannette D Moyer
  • Luanne L Peters
  • Raymond F Robledo
  • Sangmoon Yun
  • Robert S Fischer
  • Yasuko Ono
  • Kimi Y Kong
  • Katsuhiro Uzawa
  • Kimberly L Fritz-Six
  • Hideki Tanzawa
  • Masashi Shiiba
  • Tomoaki Saito
  • Atsushi Kasamatsu
  • Isao Miyamoto
  • Yosuke Endo-Sakamoto
  • Morihiro Higo
  • Pak Kin Wong
  • Cathleen Cover
  • Miensheng Chu
  • Pekka Lappalainen
  • Richard T Mathias
  • Henk L Granzier
  • Rachel M Mayfield
  • Xiurong Sun
  • Grzegorz Rebowski
  • Woo kuen Lo
  • Christine Henderson
  • Nima JamilPour
  • Elena Kremneva
  • Zachary Hernandez
  • Jose M Valdez
  • Junyuan Gao
  • Kirk R Hutchinson
  • Roberto Dominguez
  • Sondip K Biswas
  • Ki Hwan Nam
  • Caroline Pantazis
  • Jiong Chen
  • Andrea Bacconi
  • Shuangshuang Lu
  • Kevin T Gray
  • Yunshan Cao
  • Ping Wan
  • Xiu Li An
  • Hui Liu
  • Natalia Moroz
  • Amittha Wickrema
  • Jie Li
  • Alla S Kostyukova
  • Zhongzhou Yang
  • Dandan Chu
  • Edward Pate
  • Junwei Nie
  • Wen Luo
  • Dong Jin Lee
  • Myoung Hee Kim
  • Jinwoong Bok
  • Frans A Kuypers
  • X Chu
  • Sandra K Larkin
  • John Hartwig
  • Jerome R Kuszak
  • Rebecca K Zoltoski
  • Jeannette Moyer
  • Babette Gwynn
  • Diana M Gilligan
  • Kenneth E Sahr
  • Narla Mohandas
  • Steven L Ciciotte
  • Jason Nathanson

Detail Information

Publications36

  1. ncbi Cytoplasmic nuclear transfer of the actin-capping protein tropomodulin
    Kimi Y Kong
    Institute for Genetic Medicine and Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    J Biol Chem 279:30856-64. 2004
    Tropomodulin (Tmod) is a cytoskeletal actin-capping protein that interacts with tropomyosin at the pointed end of actin filaments. E-Tmod is an isoform that expresses predominantly in cardiac cells and slow skeletal muscle fibers...
  2. ncbi Cloning of tropomodulin cDNA and localization of gene transcripts during mouse embryogenesis
    M Ito
    Institute for Genetic Medicine, University of Southern California School of Medicine, Los Angeles 90033
    Dev Biol 167:317-28. 1995
    Tropomodulin (Tmod) is a tropomyosin-binding protein involved in the structuring of actin filaments...
  3. pmc Pointed-end capping by tropomodulin modulates actomyosin crossbridge formation in skeletal muscle fibers
    Julien Ochala
    1Centre of Human and Aerospace Physiological Sciences, School of Biomedical Sciences, King s College London, Rm 3 3, Shepherd s House, Guy s Campus, London SE1 1UL, UK
    FASEB J 28:408-15. 2014
    In skeletal muscle, thick and thin filaments are arranged in a myofibrillar lattice. Tropomodulin 1 (Tmod1) is a pointed-end capping and tropomyosin-binding protein that controls thin-filament assembly, stability, and lengths...
  4. pmc Tropomodulin 1 constrains fiber cell geometry during elongation and maturation in the lens cortex
    Roberta B Nowak
    The Scripps Research Institute, La Jolla, CA 92037, USA
    J Histochem Cytochem 60:414-27. 2012
    Lens fiber cells exhibit a high degree of hexagonal packing geometry, determined partly by tropomodulin 1 (Tmod1), which stabilizes the spectrin-actin network on lens fiber cell membranes...
  5. pmc Cytoplasmic gamma-actin and tropomodulin isoforms link to the sarcoplasmic reticulum in skeletal muscle fibers
    David S Gokhin
    Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Cell Biol 194:105-20. 2011
    ..In this paper, we use a genetic targeting approach to examine the effect of Tmod1 deletion on the organization of cytoplasmic γ-actin (γ(cyto)-actin) in the SR of skeletal muscle...
  6. pmc Tropomodulin 1-null mice have a mild spherocytic elliptocytosis with appearance of tropomodulin 3 in red blood cells and disruption of the membrane skeleton
    Jeannette D Moyer
    The Scripps Research Institute, La Jolla, CA 92037, USA
    Blood 116:2590-9. 2010
    The short actin filaments in the red blood cell (RBC) membrane skeleton are capped at their pointed ends by tropomodulin 1 (Tmod1) and coated with tropomyosin (TM) along their length...
  7. pmc Tropomodulin isoforms regulate thin filament pointed-end capping and skeletal muscle physiology
    David S Gokhin
    Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Cell Biol 189:95-109. 2010
    ..In this study, we use a genetic targeting approach to explore the effects of deleting Tmod1 from skeletal muscle...
  8. pmc Tropomodulin1 is required in the heart but not the yolk sac for mouse embryonic development
    Caroline R McKeown
    The Scripps Research Institute, Department of Cell Biology, La Jolla, CA 92037, USA
    Circ Res 103:1241-8. 2008
    ..Targeted deletion of mouse Tmod1 leads to defects in cardiac development, fragility of primitive erythroid cells, and an absence of yolk sac ..
  9. ncbi Mouse erythrocyte tropomodulin in the brain reported by lacZ knocked-in downstream from the E1 promoter
    Weijuan Yao
    Department of Bioengineering and Center for Molecular Genetics, University of California, San Diego, La Jolla, CA 92093 0412, USA
    Gene Expr Patterns 8:36-46. 2007
    b>Erythrocyte tropomodulin (E-Tmod, Tmod1) is a tropomyosin-binding protein that caps the slow-growing end of actin filaments. In erythrocytes, it may favor the formation of short actin protofilaments needed for elastic cell deformation...
  10. ncbi Disruption in the tropomodulin1 (Tmod1) gene compromises cardiomyocyte development in murine embryonic stem cells by arresting myofibril maturation
    Yasuko Ono
    Department of Cell Biology and Anatomy, University of Arizona, 1501 N Campbell Avenue LSN 455, Tucson, AZ 85724, USA
    Dev Biol 282:336-48. 2005
    ..To decipher the significance of Tmod1 functions during de novo myofibrillogenesis, we generated Tmod1 null embryonic stem (ES) cells and studied their ..
  11. ncbi E-Tmod capping of actin filaments at the slow-growing end is required to establish mouse embryonic circulation
    Xin Chu
    Department of Bioengineering, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0412, USA
    Am J Physiol Heart Circ Physiol 284:H1827-38. 2003
    Tropomodulins are a family of proteins that cap the slow-growing end of actin filaments. Erythrocyte tropomodulin (E-Tmod) stabilizes short actin protofilaments in erythrocytes and caps longer sarcomeric actin filaments in striated ..
  12. ncbi Leiomodins: larger members of the tropomodulin (Tmod) gene family
    C A Conley
    Space Life Sciences, MS 239 11, NASA Ames Research Center, Moffett Field, CA 94035 1000, USA
    Genomics 73:127-39. 2001
    ..D1 or 1D, first identified as a potential autoantigen in Graves' disease, is similar to the tropomodulin (Tmod) family of actin filament pointed end-capping proteins...
  13. ncbi Genomic organization of mouse and human erythrocyte tropomodulin genes encoding the pointed end capping protein for the actin filaments
    X Chu
    Department of Bioengineering and Center for Molecular Genetics, University of California, San Diego, La Jolla, CA 92093 0412, USA
    Gene 256:271-81. 2000
    b>Erythrocyte tropomodulin (E-Tmod), a globular protein of 359 residues, is highly expressed in the erythrocyte, heart and skeletal muscle...
  14. ncbi N-tropomodulin: a novel isoform of tropomodulin identified as the major binding protein to brain tropomyosin
    A Watakabe
    Cold Spring Harbor Laboratory, NY 11724, USA
    J Cell Sci 109:2299-310. 1996
    ..The neuron-specific expression of N-tropomodulin strongly suggests specialized roles of this TM-binding protein in neurons...
  15. pmc Aberrant myofibril assembly in tropomodulin1 null mice leads to aborted heart development and embryonic lethality
    Kimberly L Fritz-Six
    Department of Cell Biology, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    J Cell Biol 163:1033-44. 2003
    Tropomodulin1 (Tmod1) caps thin filament pointed ends in striated muscle, where it controls filament lengths by regulating actin dynamics. Here, we investigated myofibril assembly and heart development in a Tmod1 knockout mouse...
  16. pmc Tropomodulin1 is required for membrane skeleton organization and hexagonal geometry of fiber cells in the mouse lens
    Roberta B Nowak
    Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Cell Biol 186:915-28. 2009
    ..skeleton consists of spectrin tetramers linked to actin filaments (F-actin), which are capped by tropomodulin1 (Tmod1) and stabilized by tropomyosin (TM)...
  17. doi Overexpression of TMOD1 is associated with enhanced regional lymph node metastasis in human oral cancer
    Toshikazu Suzuki
    Department of Oral Science, Graduate School of Medicine, Chiba University, Chuo Ku, Chiba, Japan
    Int J Oncol 48:607-12. 2016
    Tropomodulin1 (TMOD1), which regulates the length and depolymerization of actin filaments by binding to the pointed end of the actin filament, has been reported to be a powerful diagnostic marker for ALK-negative anaplastic large-cell ..
  18. pmc Tropomodulin 1 directly controls thin filament length in both wild-type and tropomodulin 4-deficient skeletal muscle
    David S Gokhin
    Department of Cell and Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Development 142:4351-62. 2015
    The sarcomeric tropomodulin (Tmod) isoforms Tmod1 and Tmod4 cap thin filament pointed ends and functionally interact with the leiomodin (Lmod) isoforms Lmod2 and Lmod3 to control myofibril organization, thin filament lengths, and ..
  19. pmc Knockout of Lmod2 results in shorter thin filaments followed by dilated cardiomyopathy and juvenile lethality
    Christopher T Pappas
    Department of Cellular and Molecular Medicine, University of Arizona, Tucson, AZ 85721 Sarver Molecular Cardiovascular Research Program, University of Arizona, Tucson, AZ 85721
    Proc Natl Acad Sci U S A 112:13573-8. 2015
    ....
  20. pmc How Leiomodin and Tropomodulin use a common fold for different actin assembly functions
    Malgorzata Boczkowska
    Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Nat Commun 6:8314. 2015
    ..The WH2 domain plays only an auxiliary role in nucleation. ..
  21. pmc Lens ion homeostasis relies on the assembly and/or stability of large connexin 46 gap junction plaques on the broad sides of differentiating fiber cells
    Catherine Cheng
    Department of Cell and Molecular Biology, The Scripps Research Institute, La Jolla, California
    Am J Physiol Cell Physiol 308:C835-47. 2015
    ..We measured lens impedance in mice lacking tropomodulin 1 (Tmod1, an actin pointed-end capping protein), CP49 (a lens-specific intermediate filament protein), or both ..
  22. doi Cell type-restricted expression of erythrocyte tropomodulin Isoform41 in exon 1 knockout/LacZ knock-in heterozygous mice
    Weijuan Yao
    Department of Bioengineering, University of California, 9500 Gilman Drive, La Jolla, San Diego, CA 92093 0412, United States
    Gene Expr Patterns 17:45-55. 2015
    Full-length erythrocyte tropomodulin (E-Tmod or Tmod1) isoform of 41 kDa is an actin nucleation protein and caps the pointed end of tropomyosin-coated actin filaments...
  23. doi A cardiomyocyte-specific Wdr1 knockout demonstrates essential functional roles for actin disassembly during myocardial growth and maintenance in mice
    Baiyin Yuan
    MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing Biomedical Research Institute, Nanjing University, Nanjing, China
    Am J Pathol 184:1967-80. 2014
    ..Taken together, these results demonstrate that AIP1-regulated actin dynamics play essential roles in heart function in mice...
  24. pmc Role of tropomodulin's leucine rich repeat domain in the formation of neurite-like processes
    Laurent Guillaud
    Cellular and Molecular Synaptic Function Unit, OIST Graduate University, 1919 1 Tancha, Onna Son, Okinawa 904 0495, Japan
    Biochemistry 53:2689-700. 2014
    ..Tropomodulins (Tmod) make up a family of actin pointed end-capping proteins. Of the four known isoforms, Tmod1-Tmod3 are expressed in brain cells...
  25. pmc Tropomyosin is required for cardiac morphogenesis, myofibril assembly, and formation of adherens junctions in the developing mouse embryo
    Caroline R McKeown
    Department of Cell and Molecular Biology, The Scripps Research Institute, La Jolla, California
    Dev Dyn 243:800-17. 2014
    ..We explored a function for tropomyosin (TM) in mammalian myofibril assembly and cardiac development by analyzing a deletion in the mouse TPM1 gene targeting αTM1, the major striated muscle TM isoform...
  26. pmc Calpain-mediated proteolysis of tropomodulin isoforms leads to thin filament elongation in dystrophic skeletal muscle
    David S Gokhin
    Department of Cell and Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037 Sanford Children s Health Research Center, Sanford Burnham Medical Research Institute, La Jolla, CA 92037
    Mol Biol Cell 25:852-65. 2014
    ..Here we identify the two sarcomeric tropomodulin (Tmod) isoforms, Tmod1 and Tmod4, as novel proteolytic targets of m-calpain, with Tmod1 exhibiting ∼10-fold greater sensitivity to ..
  27. pmc Tropomodulin3-null mice are embryonic lethal with anemia due to impaired erythroid terminal differentiation in the fetal liver
    Zhenhua Sui
    The Scripps Research Institute, La Jolla, CA
    Blood 123:758-67. 2014
    Tropomodulin (Tmod) is a protein that binds and caps the pointed ends of actin filaments in erythroid and nonerythoid cell types. Targeted deletion of mouse tropomodulin3 (Tmod3) leads to embryonic lethality at E14.5-E18...
  28. pmc Tmod1 and CP49 synergize to control the fiber cell geometry, transparency, and mechanical stiffness of the mouse lens
    David S Gokhin
    Department of Cell Biology, The Scripps Research Institute, La Jolla, California, United States of America
    PLoS ONE 7:e48734. 2012
    ..interconnecting short, tropomyosin-coated actin filaments, which are stabilized by pointed-end capping by tropomodulin 1 (Tmod1) and structurally disrupted in the absence of Tmod1...
  29. ncbi The tropomodulin (Tmod) gene maps to chromosome 4, closely linked to Mup1
    R A White
    Section of Genetics, Children s Mercy Hospital, Kansas City, Missouri 64108, USA
    Mamm Genome 6:332-3. 1995
  30. ncbi Molecular diversity of myofibrillar proteins: gene regulation and functional significance
    S Schiaffino
    Department of Biomedical Sciences, University of Padova, Padua, Italy
    Physiol Rev 76:371-423. 1996
    ..Both myosin and troponin isoforms contribute to the differences in the resistance to fatigue of muscle fibers...
  31. pmc Identification of genes concordantly expressed with Atoh1 during inner ear development
    Heejei Yoon
    Department of Anatomy, Brain Korea 21 Project for Medical Science, College of Medicine, Yonsei University, Seoul, Korea
    Anat Cell Biol 44:69-78. 2011
    ..Here, by reanalyzing archived genetic profiling data, we identified a list of novel genes possibly involved in hair cell differentiation...
  32. pmc Erythrocyte tropomodulin isoforms with and without the N-terminal actin-binding domain
    Weijuan Yao
    Department of Bioengineering, University of California, San Diego, California 92093 0412, USA
    J Biol Chem 285:31408-17. 2010
    b>Erythrocyte tropomodulin (E-Tmod or Tmod1) of 41 kDa is a tropomyosin (TM)-binding protein that caps the slow-growing end of the actin filaments. Its N-terminal half is flexible, whereas the C-terminal half has a single domain structure...
  33. pmc Pathogenesis of dilated cardiomyopathy: molecular, structural, and population analyses in tropomodulin-overexpressing transgenic mice
    M A Sussman
    Division of Molecular Cardiovascular Biology, Children s Hospital and Research Foundation, Cincinnati, Ohio 45229, USA
    Am J Pathol 155:2101-13. 1999
    ....
  34. ncbi Specific expression of E-Tmod (Tmod1) in horizontal cells: implications in neuronal cell mechanics and glaucomatous retina
    Weijuan Yao
    Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093 0412, USA
    Mol Cell Biomech 6:71-82. 2009
    b>Erythrocyte tropomodulin (E-Tmod) is a tropomyosin-binding and actin capping protein at the point end of the filaments...
  35. pmc Targeted deletion of alpha-adducin results in absent beta- and gamma-adducin, compensated hemolytic anemia, and lethal hydrocephalus in mice
    Raymond F Robledo
    The Jackson Laboratory, Bar Harbor, ME, USA
    Blood 112:4298-307. 2008
    ..These data indicate that adducin plays a role in RBC membrane stability and in cerebrospinal fluid homeostasis...
  36. ncbi Induced expression of the transcription of tropomodulin 1 by Wnt5a and characterization of the tropomodulin 1 promoter
    Sangmoon Yun
    Department of Life Science, The University of Seoul, 90 Jeonnong dong, Dongdaemun Gu, Seoul 130 743, Republic of Korea
    Biochem Biophys Res Commun 363:727-32. 2007
    ..We found that Tmod1, known as an actin-capping protein, is up-regulated by Wnt5a, while gelsolin, known as an actin-severing protein, ..