Gene Symbol: Tmem173
Description: transmembrane protein 173
Alias: 2610307O08Rik, ERIS, MPYS, Mita, STING, stimulator of interferon genes protein, endoplasmic reticulum interferon stimulator, mediator of IRF3 activation, mitochondrial mediator of IRF3 activation
- STING is a direct innate immune sensor of cyclic di-GMPDara L Burdette
Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA
Nature 478:515-8. 2011..In addition, a transmembrane protein called STING (stimulator of IFN genes; also known as MITA, ERIS, MPYS and TMEM173) functions as an essential signalling adaptor, linking the cytosolic detection of DNA to the TBK1-IRF3 signalling ..
- Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNAJiaxi Wu
Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Science 339:826-30. 2013..This DNA signaling pathway requires the adaptor protein STING and the transcription factor IRF3, but the mechanism of DNA sensing is unclear...
- The innate immune DNA sensor cGAS produces a noncanonical cyclic dinucleotide that activates human STINGElie J Diner
Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
Cell Rep 3:1355-61. 2013..cGAMP activates an interferon response by binding to a downstream receptor called STING. Here, we identify natural variants of human STING (hSTING) that are poorly responsive to cGAMP yet, unexpectedly,..
- cGAS produces a 2'-5'-linked cyclic dinucleotide second messenger that activates STINGAndrea Ablasser
Institute for Clinical Chemistry and Clinical Pharmacology, University Hospital, University of Bonn, 53127 Bonn, Germany
Nature 498:380-4. 2013..The endoplasmic-reticulum-resident protein STING is critically required for the initiation of type I interferon signalling upon detection of cytosolic DNA of both ..
- Structure-function analysis of STING activation by c[G(2',5')pA(3',5')p] and targeting by antiviral DMXAAPu Gao
Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
Cell 154:748-62. 2013..triggers formation of the metazoan second messenger c[G(2',5')pA(3',5')p], which binds the signaling protein STING with subsequent activation of the interferon (IFN) pathway...
- Structure of STING bound to cyclic di-GMP reveals the mechanism of cyclic dinucleotide recognition by the immune systemChang Shu
Department of Biochemistry and Biophysics, Texas A and M University, College Station, Texas, USA
Nat Struct Mol Biol 19:722-4. 2012b>STING (stimulator of interferon genes) is an innate immune sensor of cyclic dinucleotides that regulates the induction of type I interferons...
- Autoimmunity initiates in nonhematopoietic cells and progresses via lymphocytes in an interferon-dependent autoimmune diseaseAlevtina Gall
Department of Immunology, University of Washington School of Medicine, Seattle, 98195, USA
Immunity 36:120-31. 2012..Here, we demonstrate that Trex1 is an essential negative regulator of the STING-dependent antiviral response...
- Pivotal roles of cGAS-cGAMP signaling in antiviral defense and immune adjuvant effectsXiao Dong Li
Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9148, USA
Science 341:1390-4. 2013..cGas(-/-) mice were more susceptible to lethal infection with herpes simplex virus 1 (HSV1) than wild-type mice. We also show that cGAMP is an adjuvant that boosts antigen-specific T cell activation and antibody production in mice. ..
- Activation of STAT6 by STING is critical for antiviral innate immunityHuihui Chen
State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking University, Beijing, China
Cell 147:436-46. 2011..Viruses or cytoplasmic nucleic acids trigger STING (also named MITA/ERIS) to recruit STAT6 to the endoplasmic reticulum, leading to STAT6 phosphorylation on Ser(407) ..
- Activation of autophagy by α-herpesviruses in myeloid cells is mediated by cytoplasmic viral DNA through a mechanism dependent on stimulator of IFN genesSimon B Rasmussen
Department of Biomedicine, University of Aarhus, DK 8000 Aarhus C, Denmark
J Immunol 187:5268-76. 2011..Thus, our data suggest that HSV-1 genomic DNA induces autophagy in nonpermissive cells in a stimulator of IFN gene-dependent manner...
- The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cellsZhiqiang Zhang
Department of Immunology, Center for Cancer Immunology Research, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
Nat Immunol 12:959-65. 2011..Overexpression of both DDX41 and the membrane-associated adaptor STING together had a synergistic effect in promoting Ifnb promoter activity...
- Innate immune recognition of an AT-rich stem-loop DNA motif in the Plasmodium falciparum genomeShruti Sharma
Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
Immunity 35:194-207. 2011..Rather, AT-rich DNA sensing involved an unknown receptor that coupled to the STING, TBK1 and IRF3-IRF7 signaling pathway...
- Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune responseTatsuya Saitoh
Laboratory of Host Defense, WPI Immunology Frontier Research Center, Osaka University, 3 1 Yamada oka, Suita, Osaka 565 0871, Japan
Proc Natl Acad Sci U S A 106:20842-6. 2009..Here we show that the translocation and assembly of the essential signal transducers, stimulator of IFN genes (STING) and TANK-binding kinase 1 (TBK1), are required for dsDNA-triggered innate immune responses...
- STING is an endoplasmic reticulum adaptor that facilitates innate immune signallingHiroki Ishikawa
Department of Medicine and Sylvester Comprehensive Cancer Center, University of Miami School of Medicine, Miami, Florida 33136, USA
Nature 455:674-8. 2008..Here we report the identification, following expression cloning, of a molecule (STING; stimulator of interferon genes) that appears essential for effective innate immune signalling processes...
- The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activationBo Zhong
College of Life Sciences, Wuhan University, Wuhan 430072, China
Immunity 29:538-50. 2008..Here, we identified MITA as a critical mediator of virus-triggered type I IFN signaling by expression cloning...
- ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerizationWenxiang Sun
The Education Ministry Key Laboratory of Cell Proliferation and Differentiation, School of Life Sciences, Peking University, Beijing 100871, China
Proc Natl Acad Sci U S A 106:8653-8. 2009..ERIS (also known as STING or MITA) resided exclusively on ER membrane...
- STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunityHiroki Ishikawa
Department of Medicine and Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
Nature 461:788-92. 2009..Here we show that STING (stimulator of interferon genes) is critical for the induction of IFN by non-CpG intracellular DNA species ..
- MPYS is required for IFN response factor 3 activation and type I IFN production in the response of cultured phagocytes to bacterial second messengers cyclic-di-AMP and cyclic-di-GMPLei Jin
Integrated Department of Immunology, University of Colorado Denver School of Medicine, Denver, CO 80206, USA
J Immunol 187:2595-601. 2011..IL-6, but not TNF, in response to cyclic-di-AMP and cyclic-di-GMP requires MPYS (also known as STING, MITA, and TMEM173)...
- Stimulator of IFN gene is critical for induction of IFN-beta during Chlamydia muridarum infectionDaniel Prantner
Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
J Immunol 184:2551-60. 2010..Independently, small interfering RNA-mediated knockdown of the stimulator of IFN gene (STING) protein in HeLa cells and mouse oviduct epithelial cells significantly decreased IFN-beta mRNA expression, ..
- Absent in melanoma 2 is required for innate immune recognition of Francisella tularensisJonathan W Jones
Department of Microbiology and Immunology, Stanford School of Medicine, Stanford University, Stanford, CA 94305, USA
Proc Natl Acad Sci U S A 107:9771-6. 2010..was reduced in infected macrophages lacking either the IFN-I receptor or stimulator of interferon genes (STING). Finally, AIM2-deficient mice displayed increased susceptibility to F...
- IFI16 is an innate immune sensor for intracellular DNALeonie Unterholzner
School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland
Nat Immunol 11:997-1004. 2010..IFI16 directly associated with IFN-β-inducing viral DNA motifs. STING, a critical mediator of IFN-β responses to DNA, was recruited to IFI16 after DNA stimulation...
- MPYS, a novel membrane tetraspanner, is associated with major histocompatibility complex class II and mediates transduction of apoptotic signalsLei Jin
Integrated Department of Immunology, University of Colorado School of Medicine and National Jewish Medical and Research Center, Denver, CO 80206, USA
Mol Cell Biol 28:5014-26. 2008..Here we describe a novel plasma membrane tetraspanner (MPYS) that is associated with MHC-II and mediates its transduction of death signals...
- The N-ethyl-N-nitrosourea-induced Goldenticket mouse mutant reveals an essential function of Sting in the in vivo interferon response to Listeria monocytogenes and cyclic dinucleotidesJohn Demian Sauer
Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720 3200, USA
Infect Immun 79:688-94. 2011..The transmembrane signaling adaptor Sting (Tmem173, Mita, Mpys, Eris) has recently been implicated in the induction of type I IFNs in response to cytosolic DNA and/..
- Age-enhanced endoplasmic reticulum stress contributes to increased Atg9A inhibition of STING-mediated IFN-β production during Streptococcus pneumoniae infectionDana N Mitzel
Animal Biosafety Level 3 Management Support, Lovelace Respiratory Research Institute, Albuquerque, NM 87108
J Immunol 192:4273-83. 2014..pneumoniae, and provide a possible mechanism to enhance these responses, thereby decreasing morbidity and mortality in this population...
- STING-dependent type I IFN production inhibits cell-mediated immunity to Listeria monocytogenesKristina A Archer
Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California, United States of America
PLoS Pathog 10:e1003861. 2014..monocytogenes secretes cyclic diadenosine monophosphate (c-di-AMP) which activates the innate immune sensor STING leading to the expression of IFN-β and co-regulated genes...
- NLRC3, a member of the NLR family of proteins, is a negative regulator of innate immune signaling induced by the DNA sensor STINGLu Zhang
Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA Department of Oral Biology, School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
Immunity 40:329-41. 2014Stimulator of interferon genes (STING, also named MITA, MYPS, or ERIS) is an intracellular DNA sensor that induces type I interferon through its interaction with TANK-binding kinase 1 (TBK1)...
- Activation of the STING adaptor attenuates experimental autoimmune encephalitisHenrique Lemos
Cancer Immunology, Inflammation and Tolerance Program, Cancer Center, Georgia Regents University, Augusta, GA 30912
J Immunol 192:5571-8. 2014Cytosolic DNA sensing activates the stimulator of IFN genes (STING) adaptor to induce IFN type I (IFN-αβ) production. Constitutive DNA sensing to induce sustained STING activation incites tolerance breakdown, leading to autoimmunity...
- Conventional but not plasmacytoid dendritic cells foster the systemic virus-induced type I IFN response needed for efficient CD8 T cell primingSandra Hervas-Stubbs
Division of Immunology and Immunotherapy, Center for Applied Medical Research, University of Navarra, Pamplona 31008, Spain
J Immunol 193:1151-61. 2014..involved in the virus-triggered IFN-I response is dependent on TLR9/MyD88 in pDCs and on stimulator of IFN genes (STING) in cDCs...
- Inflammation-driven carcinogenesis is mediated through STINGJeonghyun Ahn
Department of Cell Biology and Sylvester Comprehensive Cancer Center, University of Miami School of Medicine, Miami, Florida 33136, USA
Nat Commun 5:5166. 2014..etoposide induce nuclear DNA leakage into the cytosol that intrinsically activates stimulator of interferon genes (STING)-dependent cytokine production...
- STING contributes to antiglioma immunity via triggering type I IFN signals in the tumor microenvironmentTakayuki Ohkuri
Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania Department of Brain Tumor, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania
Cancer Immunol Res 2:1199-208. 2014..CD11b(+) brain-infiltrating leukocytes (BIL) are the main source of type I IFNs that are induced partially in a STING (stimulator of IFN genes)-dependent manner...
- STING-dependent cytosolic DNA sensing mediates innate immune recognition of immunogenic tumorsSeng Ryong Woo
Department of Pathology, The University of Chicago, 929 E57th Street GCIS W423H, Chicago, IL 60637, USA
Immunity 41:830-42. 2014..CD8(+) T cell priming against tumors was defective in mice lacking stimulator of interferon genes complex (STING), but not other innate signaling pathways, suggesting involvement of a cytosolic DNA sensing pathway...
- STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic TumorsLiufu Deng
Department of Radiation and Cellular Oncology, University of Chicago, Chicago, IL 60637, USA The Ludwig Center for Metastasis Research, University of Chicago, Chicago, IL 60637, USA
Immunity 41:843-52. 2014..Here, we demonstrate that adaptor protein STING, but not MyD88, is required for type I IFN-dependent antitumor effects of radiation...
- The Hippo Pathway Kinases LATS1/2 Suppress Cancer ImmunityToshiro Moroishi
Department of Pharmacology and Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA
Cell 167:1525-1539.e17. 2016..Our observations uncover a key role of the Hippo pathway in modulating tumor immunogenicity and demonstrate a proof of concept for targeting LATS1/2 in cancer immunotherapy...
- MAVS, cGAS, and endogenous retroviruses in T-independent B cell responsesMing Zeng
Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 8502, USA
Science 346:1486-92. 2014..signaling protein (MAVS)-dependent RNA sensing pathway or reverse-transcribed and detected via the cGAS-cGAMP-STING pathway, triggering a second, sustained wave of signaling that promotes specific immunoglobulin M production...
- DNA damage primes the type I interferon system via the cytosolic DNA sensor STING to promote anti-microbial innate immunityAnetta Hartlova
Laboratory for Molecular Infection Medicine Sweden, Umea University, 90 187 Umeå, Sweden Department of Molecular Biology, Umea University, 90 187 Umeå, Sweden Umeå Centre for Microbial Research, Umea University, 90 187 Umeå, Sweden
Immunity 42:332-43. 2015..system by DNA damage involved release of DNA into the cytoplasm where it activated the cytosolic DNA sensing STING-mediated pathway, which in turn enhanced responses to innate stimuli by activating the expression of Toll-like ..
- PPM1A regulates antiviral signaling by antagonizing TBK1-mediated STING phosphorylation and aggregationZexing Li
State Key Laboratory of Biomembrane and Membrane Biotechnology, Chinese Academy of Sciences, Chaoyang District, Beijing, China
PLoS Pathog 11:e1004783. 2015Stimulator of interferon genes (STING, also known as MITA and ERIS) is critical in protecting the host against DNA pathogen invasion. However, the molecular mechanism underlying the regulation of STING remains unclear...
- STING Negatively Regulates Double-Stranded DNA-Activated JAK1-STAT1 Signaling via SHP-1/2 in B CellsGuanjun Dong
The State Key Laboratory of Pharmaceutical Biotechnology, Division of Immunology, Medical School, Nanjing University, Nanjing 210093, China
Mol Cells 38:441-51. 2015..The stimulator of interferon genes protein (STING) has been demonstrated to be a critical hub of type I IFN induction in cytosolic DNA-..
- Cutting Edge: cGAS Is Required for Lethal Autoimmune Disease in the Trex1-Deficient Mouse Model of Aicardi-Goutières SyndromeElizabeth E Gray
Department of Immunology, University of Washington School of Medicine, Seattle, WA 98195
J Immunol 195:1939-43. 2015..These findings implicate cGAS as a key driver of autoimmune disease and suggest that cGAS inhibitors may be useful therapeutics for Aicardi-Goutières syndrome and related autoimmune diseases...
- Cytosolic Nuclease TREX1 Regulates Oligosaccharyltransferase Activity Independent of Nuclease Activity to Suppress Immune ActivationMaroof Hasan
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Immunity 43:463-74. 2015..This function of the TREX1 C terminus suggests a potential therapeutic option for TREX1-fs mutant-associated diseases. ..
- Isoforms of RNA-Editing Enzyme ADAR1 Independently Control Nucleic Acid Sensor MDA5-Driven Autoimmunity and Multi-organ DevelopmentKathleen Pestal
Department of Immunology, University of Washington School of Medicine, Seattle, WA 98195, USA
Immunity 43:933-44. 2015..Our findings delineate genetically separable roles for both ADAR1 isoforms in vivo, with implications for the human diseases caused by ADAR mutations. ..
- Rat and human STINGs profile similarly towards anticancer/antiviral compoundsHeng Zhang
State Key Laboratory of Protein and Plant Gene Research, and Biodynamic Optical Imaging Center BIOPIC, School of Life Sciences, Peking University, Beijing 100871, China
Sci Rep 5:18035. 2015Cyclic dinucleotides (CDNs) and antitumor/antiviral agents (DMXAA and CMA) trigger STING-dependent innate immunity activation...
- Cutting Edge: Novel Tmem173 Allele Reveals Importance of STING N Terminus in Trafficking and Type I IFN ProductionGuy Surpris
Program in Immunology, Tufts University, Boston, MA 02111
J Immunol 196:547-52. 2016With the stimulator of IFN genes (STING) C terminus being extensively studied, the role of the N-terminal domain (NTD) of STING remains an important subject of investigation...
- Influenza A virus targets a cGAS-independent STING pathway that controls enveloped RNA virusesChristian K Holm
Department of Biomedicine, Aarhus University, Aarhus 8000, Denmark
Nat Commun 7:10680. 2016Stimulator of interferon genes (STING) is known be involved in control of DNA viruses but has an unexplored role in control of RNA viruses...
- Antagonism of the STING Pathway via Activation of the AIM2 Inflammasome by Intracellular DNALeticia Corrales
Department of Pathology, The University of Chicago, Chicago, IL 60637
J Immunol 196:3191-8. 2016Recent evidence has indicated that innate immune sensing of cytosolic DNA in dendritic cells via the host STING pathway is a major mechanism leading to spontaneous T cell responses against tumors...
- NLRX1 Sequesters STING to Negatively Regulate the Interferon Response, Thereby Facilitating the Replication of HIV-1 and DNA VirusesHaitao Guo
Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
Cell Host Microbe 19:515-28. 2016..NLRX1 sequesters the DNA-sensing adaptor STING from interaction with TANK-binding kinase 1 (TBK1), which is a requisite for IFN-1 induction in response to DNA...
- The AIM2-like Receptors Are Dispensable for the Interferon Response to Intracellular DNAElizabeth E Gray
Department of Immunology, University of Washington School of Medicine, Seattle, WA, 98195, USA
Immunity 45:255-66. 2016Detection of intracellular DNA triggers activation of the STING-dependent interferon-stimulatory DNA (ISD) pathway, which is essential for antiviral responses...
- Adenovirus detection by the cGAS/STING/TBK1 DNA sensing cascadeEric Lam
Weill Medical College of Cornell University, Department of Microbiology and Immunology, Molecular Biology Graduate Program, New York, New York, USA
J Virol 88:974-81. 2014..GMP-AMP synthase (cGAS), a DNA sensor that produces a cyclic guanine-adenine dinucleotide (cGAMP) inducer of STING, has been examined to determine its role in generating an antiadenoviral response...
- STING-IRF3 pathway links endoplasmic reticulum stress with hepatocyte apoptosis in early alcoholic liver diseaseJan Petrasek
Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605
Proc Natl Acad Sci U S A 110:16544-9. 2013..induced ER stress and triggered the association of IRF3 with the ER adaptor, stimulator of interferon genes (STING), as well as subsequent phosphorylation of IRF3...
- Cutting edge: DNA sensing via the STING adaptor in myeloid dendritic cells induces potent tolerogenic responsesLei Huang
Cancer Immunology, Inflammation and Tolerance Program, Cancer Center, Augusta, GA 30912
J Immunol 191:3509-13. 2013Cytosolic DNA sensing via the stimulator of IFN genes (STING) adaptor incites autoimmunity by inducing type I IFN (IFN-αβ). In this study, we show that DNA is also sensed via STING to suppress immunity by inducing IDO...
- Species-specific detection of the antiviral small-molecule compound CMA by STINGTaner Cavlar
Unit for Clinical Biochemistry, Institute for Clinical Chemistry and Clinical Pharmacology, University Hospital, University of Bonn, Bonn, Germany
EMBO J 32:1440-50. 2013..Here we demonstrate that CMA mediates a cell-intrinsic type I IFN response, depending on the ER-resident protein STING. CMA directly binds to STING and triggers a strong antiviral response through the TBK1/IRF3 route...
- The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I interferon immune responseKislay Parvatiyar
Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, California, USA
Nat Immunol 13:1155-61. 2012..cyclic di-GMP (c-di-GMP) or cyclic di-AMP (c-di-AMP) is dependent on a signaling axis that involves the adaptor STING, the kinase TBK1 and the transcription factor IRF3...
- Innate immune response induced by baculovirus attenuates transgene expression in mammalian cellsChikako Ono
Department of Molecular Virology, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan
J Virol 88:2157-67. 2014..transduction by the recombinant baculovirus was achieved in MEFs deficient for stimulator of interferon genes (STING), TANK binding kinase 1 (TBK1), IFN regulatory factor 3 (IRF3), or IFN-β promoter stimulator 1 (IPS-1), but not ..
- STING manifests self DNA-dependent inflammatory diseaseJeonghyun Ahn
Department of Cell Biology and Sylvester Comprehensive Cancer Center, University of Miami School of Medicine, Miami, FL 33136, USA
Proc Natl Acad Sci U S A 109:19386-91. 2012..However, we report here that Stimulator of IFN Genes (STING) is responsible for inflammation-related embryonic death in DNase II defective mice initiated by self DNA...
- Streptococcus pneumoniae stimulates a STING- and IFN regulatory factor 3-dependent type I IFN production in macrophages, which regulates RANTES production in macrophages, cocultured alveolar epithelial cells, and mouse lungsUwe Koppe
Department of Internal Medicine Infectious Diseases and Pulmonary Medicine, Charite University Medicine Berlin, 13353 Berlin, Germany
J Immunol 188:811-7. 2012..toxin pneumolysin and appeared to be mediated by a cytosolic DNA-sensing pathway involving the adapter molecule STING and the transcription factor IFN regulatory factor 3...
- Virus-cell fusion as a trigger of innate immunity dependent on the adaptor STINGChristian K Holm
Department of Biomedicine, Aarhus University, Aarhus, Denmark
Nat Immunol 13:737-43. 2012..The fusion-dependent response was dependent on the stimulator of interferon genes STING but was independent of DNA, RNA and viral capsid...
- LSm14A is a processing body-associated sensor of viral nucleic acids that initiates cellular antiviral response in the early phase of viral infectionYing Li
State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China
Proc Natl Acad Sci U S A 109:11770-5. 2012..We further found that LSm14A-mediated IFN-β induction requires RIG-I-VISA or MITA after RNA or DNA virus infection, respectively, and viral infection causes translocation of LSm14A to peroxisomes, ..
- TRIF licenses caspase-11-dependent NLRP3 inflammasome activation by gram-negative bacteriaVijay A K Rathinam
Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
Cell 150:606-19. 2012..The identification of TRIF as a regulator of caspase-11 underscores the importance of TLRs as master regulators of inflammasomes during Gram-negative bacterial infection...
- Crystallization studies of the murine c-di-GMP sensor protein STINGYi Che Su
Institute of Biochemistry, National Chung Hsing University, Taichung 40227, Taiwan
Acta Crystallogr Sect F Struct Biol Cryst Commun 68:906-10. 2012..Recently, the mammalian ER membrane protein STING (stimulator of IFN genes; also known as MITA, ERIS, MPYS and TMEM173) has been found to be the master regulator linking the detection of cytosolic DNA to TANK-binding kinase 1 (TBK1) ..
- 5,6-Dimethylxanthenone-4-acetic acid (DMXAA) activates stimulator of interferon gene (STING)-dependent innate immune pathways and is regulated by mitochondrial membrane potentialDaniel Prantner
Department of Microbiology and Immunology, University of Maryland, School of Medicine UMB, Baltimore, Maryland 21201, USA
J Biol Chem 287:39776-88. 2012..in response to DMXAA in mouse macrophages requires the mitochondrial and endoplasmic reticulum resident protein STING. Addition of the antioxidant diphenylene iodonium (DPI) diminished DMXAA-induced IFN-β, but this decrease was ..
- Endoplasmic reticulum stress regulates the innate immunity critical transcription factor IRF3Yi Ping Liu
Department of Pediatrics, School of Medicine and Public Health, University of Wisconsin, Madison, WI 53792, USA
J Immunol 189:4630-9. 2012..Our results also suggest certain types of ER stress accomplish IRF3 phosphorylation by co-opting existing innate immune pathogen response pathways. These data have implications for diseases involving ER stress and type I IFN...
- Extensive evolutionary and functional diversity among mammalian AIM2-like receptorsRebecca L Brunette
Department of Immunology, University of Washington School of Medicine, Seattle, WA 98195, USA
J Exp Med 209:1969-83. 2012..Detection of intracellular DNA activates STING-dependent type I interferons (IFNs) and the ASC-dependent inflammasome...
- DENV inhibits type I IFN production in infected cells by cleaving human STINGSebastian Aguirre
Department of Microbiology and the Global Health and Emerging Pathogens Institute, Mount Sinai School of Medicine, New York City, New York, United States of America
PLoS Pathog 8:e1002934. 2012..In the present report we identify the human adaptor molecule STING as a target of the NS2B3 protease complex...
- DNA-PK is a DNA sensor for IRF-3-dependent innate immunityBrian J Ferguson
Department of Virology, Imperial College London, London, United Kingdom Department of Pathology, University of Cambridge, Cambridge, United Kingdom
elife 1:e00047. 2012..dependent on IFN regulatory factor 3 (IRF-3), TANK-binding kinase 1 (TBK1) and stimulator of interferon genes (STING)...
- STING/MPYS mediates host defense against Listeria monocytogenes infection by regulating Ly6C(hi) monocyte migrationLei Jin
Integrated Department of Immunology, University of Colorado Denver School of Medicine and National Jewish Health, Denver, CO 80206, USA
J Immunol 190:2835-43. 2013MPYS (also known as STING, MITA, and TMEM173) is a type I IFN stimulator that is essential for host defense against DNA virus infection and appears important in defense against certain bacteria...
- DNA damage sensor MRE11 recognizes cytosolic double-stranded DNA and induces type I interferon by regulating STING traffickingTakeshi Kondo
Laboratory of Host Defense, World Premier International Research Center Initiative WPI Immunology Frontier Research Center, Osaka University, Osaka 565 0871, Japan
Proc Natl Acad Sci U S A 110:2969-74. 2013..physically interacted with dsDNA in the cytoplasm and was required for activation of stimulator of IFN genes (STING) and IRF3...
- Interferon-γ and granulocyte/monocyte colony-stimulating factor production by natural killer cells involves different signaling pathways and the adaptor stimulator of interferon genes (STING)Fernando Souza-Fonseca-Guimarães
Institut Pasteur, Unit of Cytokines and Inflammation, Department Infection et Epidémiologie, 28 rue du Dr Roux, F 75015 Paris, France
J Biol Chem 288:10715-21. 2013..IFN-γ production was found to be MyD88- and TLR9-dependent, whereas GM-CSF was TLR9-independent but dependent on STING (stimulator of interferon genes), a cytosolic adaptor recently described for DNA sensing...
- Novel c-di-GMP recognition modes of the mouse innate immune adaptor protein STINGKo Hsin Chin
Agricultural Biotechnology Center, National Chung Hsing University, Taichung 40227, Taiwan
Acta Crystallogr D Biol Crystallogr 69:352-66. 2013The mammalian ER protein STING (stimulator of interferon genes; also known as MITA, ERIS, MPYS or TMEM173) is an adaptor protein that links the detection of cytosolic dsDNA to the activation of TANK-binding kinase 1 (TBK1) and its ..
- Mouse, but not human STING, binds and signals in response to the vascular disrupting agent 5,6-dimethylxanthenone-4-acetic acidJoseph Conlon
Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
J Immunol 190:5216-25. 2013..In this study, we identify stimulator of IFN gene (STING) as a direct receptor for DMXAA leading to TANK-binding kinase 1 and IFN regulatory factor 3 signaling...
- MyD88 and STING signaling pathways are required for IRF3-mediated IFN-β induction in response to Brucella abortus infectionLeonardo A de Almeida
Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte Minas Gerais, Brazil
PLoS ONE 6:e23135. 2011..a mechanism dependent on RNA polymerase III to be sensed probably by an unknown receptor via the adaptor molecule STING. Finally, we have demonstrated that IFN-αβR KO mice are more resistant to infection suggesting that type I IFN ..
- Cellular reactive oxygen species inhibit MPYS induction of IFNβLei Jin
Integrated Department of Immunology, University of Colorado Denver School of Medicine and National Jewish Health, Denver, Colorado, United States of America
PLoS ONE 5:e15142. 2010..Here we report that MPYS, a.k.a. STING, which was recently shown to mediate activation of IFNβ expression during infection, is a ROS sensor...
- The ubiquitin ligase TRIM56 regulates innate immune responses to intracellular double-stranded DNATetsuo Tsuchida
Laboratory of Host Defense, WPI Immunology Frontier Research Center, Osaka University, Osaka 565 0871, Japan
Immunity 33:765-76. 2010..TRIM56 interacted with STING and targeted it for lysine 63-linked ubiquitination...
- NF-kB activating genePatent Number: WO03048202-A2; Date:2003-06-12