Tmem173

Summary

Gene Symbol: Tmem173
Description: transmembrane protein 173
Alias: 2610307O08Rik, ERIS, MPYS, Mita, STING, stimulator of interferon genes protein, endoplasmic reticulum interferon stimulator, mediator of IRF3 activation, mitochondrial mediator of IRF3 activation
Species: mouse

Top Publications

  1. pmc STING is a direct innate immune sensor of cyclic di-GMP
    Dara L Burdette
    Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA
    Nature 478:515-8. 2011
  2. pmc Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA
    Jiaxi Wu
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Science 339:826-30. 2013
  3. pmc The innate immune DNA sensor cGAS produces a noncanonical cyclic dinucleotide that activates human STING
    Elie J Diner
    Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
    Cell Rep 3:1355-61. 2013
  4. pmc cGAS produces a 2'-5'-linked cyclic dinucleotide second messenger that activates STING
    Andrea Ablasser
    Institute for Clinical Chemistry and Clinical Pharmacology, University Hospital, University of Bonn, 53127 Bonn, Germany
    Nature 498:380-4. 2013
  5. pmc Structure-function analysis of STING activation by c[G(2',5')pA(3',5')p] and targeting by antiviral DMXAA
    Pu Gao
    Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Cell 154:748-62. 2013
  6. pmc Structure of STING bound to cyclic di-GMP reveals the mechanism of cyclic dinucleotide recognition by the immune system
    Chang Shu
    Department of Biochemistry and Biophysics, Texas A and M University, College Station, Texas, USA
    Nat Struct Mol Biol 19:722-4. 2012
  7. pmc Autoimmunity initiates in nonhematopoietic cells and progresses via lymphocytes in an interferon-dependent autoimmune disease
    Alevtina Gall
    Department of Immunology, University of Washington School of Medicine, Seattle, 98195, USA
    Immunity 36:120-31. 2012
  8. pmc Pivotal roles of cGAS-cGAMP signaling in antiviral defense and immune adjuvant effects
    Xiao Dong Li
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9148, USA
    Science 341:1390-4. 2013
  9. doi Activation of STAT6 by STING is critical for antiviral innate immunity
    Huihui Chen
    State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking University, Beijing, China
    Cell 147:436-46. 2011
  10. pmc Activation of autophagy by α-herpesviruses in myeloid cells is mediated by cytoplasmic viral DNA through a mechanism dependent on stimulator of IFN genes
    Simon B Rasmussen
    Department of Biomedicine, University of Aarhus, DK 8000 Aarhus C, Denmark
    J Immunol 187:5268-76. 2011

Patents

  1. NF-kB activating gene

Scientific Experts

  • Sandra Hervas-Stubbs
  • Glen N Barber
  • Katherine A Fitzgerald
  • Lei Jin
  • Shruti Sharma
  • Daniel B Stetson
  • Christian K Holm
  • Dara L Burdette
  • Yoshihiro Hayakawa
  • Tatsuya Saitoh
  • Elizabeth E Gray
  • Hiroki Ishikawa
  • Zhijian J Chen
  • Xiao Dong Li
  • Lu Zhang
  • Jeonghyun Ahn
  • Søren R Paludan
  • Russell E Vance
  • Delia Gutman
  • Taro Kawai
  • Shizuo Akira
  • Daniel Prantner
  • John C Cambier
  • Leticia Corrales
  • Seng Ryong Woo
  • Thomas F Gajewski
  • Veit Hornung
  • Henrique Lemos
  • Lei Huang
  • Taner Cavlar
  • Andrea Ablasser
  • Jiaxi Wu
  • Ko Hsin Chin
  • Yi Che Su
  • Vijay A K Rathinam
  • Mamoru Hyodo
  • Kathryn M Monroe
  • Zhiqiang Zhang
  • Simon B Rasmussen
  • Hong Bing Shu
  • Kristy A Horan
  • Søren B Jensen
  • Ying Li
  • Huihui Chen
  • Wenxiang Sun
  • Toshiro Moroishi
  • Guy Surpris
  • Haitao Guo
  • Jessica M Snyder
  • Zhigang Zhang
  • Jenny P Y Ting
  • Zexing Li
  • Piper M Treuting
  • Joseph A Duncan
  • Blossom Damania
  • Kathleen Pestal
  • Guanjun Dong
  • Heng Zhang
  • Maroof Hasan
  • Haitao Wen
  • Anetta Hartlova
  • Jinyao Mo
  • Alex Petrucelli
  • Mikayla Thompson
  • Chikako Ono
  • Liufu Deng
  • Kristina A Archer
  • Eric Lam
  • Dana N Mitzel
  • Takayuki Ohkuri
  • Ming Zeng
  • Martin R Jakobsen
  • David H Munn
  • Ken J Ishii
  • Jennie Chan
  • Andrew L Mellor
  • Gabriela Pacholczyk
  • Lingqian Li
  • Phillip R Chandler
  • Yan Jiang
  • Elie J Diner
  • Joshua J Woodward
  • Tobias Deimling
  • Pu Gao
  • Lijun Sun
  • Songying Ouyang
  • Takeshi Kondo
  • Joseph Conlon
  • Karl Peter Hopfner
  • Jan Petrasek

Detail Information

Publications72

  1. pmc STING is a direct innate immune sensor of cyclic di-GMP
    Dara L Burdette
    Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA
    Nature 478:515-8. 2011
    ..In addition, a transmembrane protein called STING (stimulator of IFN genes; also known as MITA, ERIS, MPYS and TMEM173) functions as an essential signalling adaptor, linking the cytosolic detection of DNA to the TBK1-IRF3 signalling ..
  2. pmc Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA
    Jiaxi Wu
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Science 339:826-30. 2013
    ..This DNA signaling pathway requires the adaptor protein STING and the transcription factor IRF3, but the mechanism of DNA sensing is unclear...
  3. pmc The innate immune DNA sensor cGAS produces a noncanonical cyclic dinucleotide that activates human STING
    Elie J Diner
    Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
    Cell Rep 3:1355-61. 2013
    ..cGAMP activates an interferon response by binding to a downstream receptor called STING. Here, we identify natural variants of human STING (hSTING) that are poorly responsive to cGAMP yet, unexpectedly,..
  4. pmc cGAS produces a 2'-5'-linked cyclic dinucleotide second messenger that activates STING
    Andrea Ablasser
    Institute for Clinical Chemistry and Clinical Pharmacology, University Hospital, University of Bonn, 53127 Bonn, Germany
    Nature 498:380-4. 2013
    ..The endoplasmic-reticulum-resident protein STING is critically required for the initiation of type I interferon signalling upon detection of cytosolic DNA of both ..
  5. pmc Structure-function analysis of STING activation by c[G(2',5')pA(3',5')p] and targeting by antiviral DMXAA
    Pu Gao
    Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Cell 154:748-62. 2013
    ..triggers formation of the metazoan second messenger c[G(2',5')pA(3',5')p], which binds the signaling protein STING with subsequent activation of the interferon (IFN) pathway...
  6. pmc Structure of STING bound to cyclic di-GMP reveals the mechanism of cyclic dinucleotide recognition by the immune system
    Chang Shu
    Department of Biochemistry and Biophysics, Texas A and M University, College Station, Texas, USA
    Nat Struct Mol Biol 19:722-4. 2012
    b>STING (stimulator of interferon genes) is an innate immune sensor of cyclic dinucleotides that regulates the induction of type I interferons...
  7. pmc Autoimmunity initiates in nonhematopoietic cells and progresses via lymphocytes in an interferon-dependent autoimmune disease
    Alevtina Gall
    Department of Immunology, University of Washington School of Medicine, Seattle, 98195, USA
    Immunity 36:120-31. 2012
    ..Here, we demonstrate that Trex1 is an essential negative regulator of the STING-dependent antiviral response...
  8. pmc Pivotal roles of cGAS-cGAMP signaling in antiviral defense and immune adjuvant effects
    Xiao Dong Li
    Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9148, USA
    Science 341:1390-4. 2013
    ..cGas(-/-) mice were more susceptible to lethal infection with herpes simplex virus 1 (HSV1) than wild-type mice. We also show that cGAMP is an adjuvant that boosts antigen-specific T cell activation and antibody production in mice. ..
  9. doi Activation of STAT6 by STING is critical for antiviral innate immunity
    Huihui Chen
    State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, Peking University, Beijing, China
    Cell 147:436-46. 2011
    ..Viruses or cytoplasmic nucleic acids trigger STING (also named MITA/ERIS) to recruit STAT6 to the endoplasmic reticulum, leading to STAT6 phosphorylation on Ser(407) ..
  10. pmc Activation of autophagy by α-herpesviruses in myeloid cells is mediated by cytoplasmic viral DNA through a mechanism dependent on stimulator of IFN genes
    Simon B Rasmussen
    Department of Biomedicine, University of Aarhus, DK 8000 Aarhus C, Denmark
    J Immunol 187:5268-76. 2011
    ..Thus, our data suggest that HSV-1 genomic DNA induces autophagy in nonpermissive cells in a stimulator of IFN gene-dependent manner...
  11. pmc The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells
    Zhiqiang Zhang
    Department of Immunology, Center for Cancer Immunology Research, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    Nat Immunol 12:959-65. 2011
    ..Overexpression of both DDX41 and the membrane-associated adaptor STING together had a synergistic effect in promoting Ifnb promoter activity...
  12. pmc Innate immune recognition of an AT-rich stem-loop DNA motif in the Plasmodium falciparum genome
    Shruti Sharma
    Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
    Immunity 35:194-207. 2011
    ..Rather, AT-rich DNA sensing involved an unknown receptor that coupled to the STING, TBK1 and IRF3-IRF7 signaling pathway...
  13. pmc Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response
    Tatsuya Saitoh
    Laboratory of Host Defense, WPI Immunology Frontier Research Center, Osaka University, 3 1 Yamada oka, Suita, Osaka 565 0871, Japan
    Proc Natl Acad Sci U S A 106:20842-6. 2009
    ..Here we show that the translocation and assembly of the essential signal transducers, stimulator of IFN genes (STING) and TANK-binding kinase 1 (TBK1), are required for dsDNA-triggered innate immune responses...
  14. pmc STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling
    Hiroki Ishikawa
    Department of Medicine and Sylvester Comprehensive Cancer Center, University of Miami School of Medicine, Miami, Florida 33136, USA
    Nature 455:674-8. 2008
    ..Here we report the identification, following expression cloning, of a molecule (STING; stimulator of interferon genes) that appears essential for effective innate immune signalling processes...
  15. doi The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation
    Bo Zhong
    College of Life Sciences, Wuhan University, Wuhan 430072, China
    Immunity 29:538-50. 2008
    ..Here, we identified MITA as a critical mediator of virus-triggered type I IFN signaling by expression cloning...
  16. pmc ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization
    Wenxiang Sun
    The Education Ministry Key Laboratory of Cell Proliferation and Differentiation, School of Life Sciences, Peking University, Beijing 100871, China
    Proc Natl Acad Sci U S A 106:8653-8. 2009
    ..ERIS (also known as STING or MITA) resided exclusively on ER membrane...
  17. pmc STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity
    Hiroki Ishikawa
    Department of Medicine and Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    Nature 461:788-92. 2009
    ..Here we show that STING (stimulator of interferon genes) is critical for the induction of IFN by non-CpG intracellular DNA species ..
  18. pmc MPYS is required for IFN response factor 3 activation and type I IFN production in the response of cultured phagocytes to bacterial second messengers cyclic-di-AMP and cyclic-di-GMP
    Lei Jin
    Integrated Department of Immunology, University of Colorado Denver School of Medicine, Denver, CO 80206, USA
    J Immunol 187:2595-601. 2011
    ..IL-6, but not TNF, in response to cyclic-di-AMP and cyclic-di-GMP requires MPYS (also known as STING, MITA, and TMEM173)...
  19. pmc Stimulator of IFN gene is critical for induction of IFN-beta during Chlamydia muridarum infection
    Daniel Prantner
    Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    J Immunol 184:2551-60. 2010
    ..Independently, small interfering RNA-mediated knockdown of the stimulator of IFN gene (STING) protein in HeLa cells and mouse oviduct epithelial cells significantly decreased IFN-beta mRNA expression, ..
  20. pmc Absent in melanoma 2 is required for innate immune recognition of Francisella tularensis
    Jonathan W Jones
    Department of Microbiology and Immunology, Stanford School of Medicine, Stanford University, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 107:9771-6. 2010
    ..was reduced in infected macrophages lacking either the IFN-I receptor or stimulator of interferon genes (STING). Finally, AIM2-deficient mice displayed increased susceptibility to F...
  21. pmc IFI16 is an innate immune sensor for intracellular DNA
    Leonie Unterholzner
    School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland
    Nat Immunol 11:997-1004. 2010
    ..IFI16 directly associated with IFN-β-inducing viral DNA motifs. STING, a critical mediator of IFN-β responses to DNA, was recruited to IFI16 after DNA stimulation...
  22. pmc MPYS, a novel membrane tetraspanner, is associated with major histocompatibility complex class II and mediates transduction of apoptotic signals
    Lei Jin
    Integrated Department of Immunology, University of Colorado School of Medicine and National Jewish Medical and Research Center, Denver, CO 80206, USA
    Mol Cell Biol 28:5014-26. 2008
    ..Here we describe a novel plasma membrane tetraspanner (MPYS) that is associated with MHC-II and mediates its transduction of death signals...
  23. pmc The N-ethyl-N-nitrosourea-induced Goldenticket mouse mutant reveals an essential function of Sting in the in vivo interferon response to Listeria monocytogenes and cyclic dinucleotides
    John Demian Sauer
    Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720 3200, USA
    Infect Immun 79:688-94. 2011
    ..The transmembrane signaling adaptor Sting (Tmem173, Mita, Mpys, Eris) has recently been implicated in the induction of type I IFNs in response to cytosolic DNA and/..
  24. pmc Age-enhanced endoplasmic reticulum stress contributes to increased Atg9A inhibition of STING-mediated IFN-β production during Streptococcus pneumoniae infection
    Dana N Mitzel
    Animal Biosafety Level 3 Management Support, Lovelace Respiratory Research Institute, Albuquerque, NM 87108
    J Immunol 192:4273-83. 2014
    ..pneumoniae, and provide a possible mechanism to enhance these responses, thereby decreasing morbidity and mortality in this population...
  25. pmc STING-dependent type I IFN production inhibits cell-mediated immunity to Listeria monocytogenes
    Kristina A Archer
    Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California, United States of America
    PLoS Pathog 10:e1003861. 2014
    ..monocytogenes secretes cyclic diadenosine monophosphate (c-di-AMP) which activates the innate immune sensor STING leading to the expression of IFN-β and co-regulated genes...
  26. pmc NLRC3, a member of the NLR family of proteins, is a negative regulator of innate immune signaling induced by the DNA sensor STING
    Lu Zhang
    Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA Department of Oral Biology, School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Immunity 40:329-41. 2014
    Stimulator of interferon genes (STING, also named MITA, MYPS, or ERIS) is an intracellular DNA sensor that induces type I interferon through its interaction with TANK-binding kinase 1 (TBK1)...
  27. pmc Activation of the STING adaptor attenuates experimental autoimmune encephalitis
    Henrique Lemos
    Cancer Immunology, Inflammation and Tolerance Program, Cancer Center, Georgia Regents University, Augusta, GA 30912
    J Immunol 192:5571-8. 2014
    Cytosolic DNA sensing activates the stimulator of IFN genes (STING) adaptor to induce IFN type I (IFN-αβ) production. Constitutive DNA sensing to induce sustained STING activation incites tolerance breakdown, leading to autoimmunity...
  28. pmc Conventional but not plasmacytoid dendritic cells foster the systemic virus-induced type I IFN response needed for efficient CD8 T cell priming
    Sandra Hervas-Stubbs
    Division of Immunology and Immunotherapy, Center for Applied Medical Research, University of Navarra, Pamplona 31008, Spain
    J Immunol 193:1151-61. 2014
    ..involved in the virus-triggered IFN-I response is dependent on TLR9/MyD88 in pDCs and on stimulator of IFN genes (STING) in cDCs...
  29. pmc Inflammation-driven carcinogenesis is mediated through STING
    Jeonghyun Ahn
    Department of Cell Biology and Sylvester Comprehensive Cancer Center, University of Miami School of Medicine, Miami, Florida 33136, USA
    Nat Commun 5:5166. 2014
    ..etoposide induce nuclear DNA leakage into the cytosol that intrinsically activates stimulator of interferon genes (STING)-dependent cytokine production...
  30. pmc STING contributes to antiglioma immunity via triggering type I IFN signals in the tumor microenvironment
    Takayuki Ohkuri
    Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania Department of Brain Tumor, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania
    Cancer Immunol Res 2:1199-208. 2014
    ..CD11b(+) brain-infiltrating leukocytes (BIL) are the main source of type I IFNs that are induced partially in a STING (stimulator of IFN genes)-dependent manner...
  31. pmc STING-dependent cytosolic DNA sensing mediates innate immune recognition of immunogenic tumors
    Seng Ryong Woo
    Department of Pathology, The University of Chicago, 929 E57th Street GCIS W423H, Chicago, IL 60637, USA
    Immunity 41:830-42. 2014
    ..CD8(+) T cell priming against tumors was defective in mice lacking stimulator of interferon genes complex (STING), but not other innate signaling pathways, suggesting involvement of a cytosolic DNA sensing pathway...
  32. pmc STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors
    Liufu Deng
    Department of Radiation and Cellular Oncology, University of Chicago, Chicago, IL 60637, USA The Ludwig Center for Metastasis Research, University of Chicago, Chicago, IL 60637, USA
    Immunity 41:843-52. 2014
    ..Here, we demonstrate that adaptor protein STING, but not MyD88, is required for type I IFN-dependent antitumor effects of radiation...
  33. doi The Hippo Pathway Kinases LATS1/2 Suppress Cancer Immunity
    Toshiro Moroishi
    Department of Pharmacology and Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA
    Cell 167:1525-1539.e17. 2016
    ..Our observations uncover a key role of the Hippo pathway in modulating tumor immunogenicity and demonstrate a proof of concept for targeting LATS1/2 in cancer immunotherapy...
  34. pmc MAVS, cGAS, and endogenous retroviruses in T-independent B cell responses
    Ming Zeng
    Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 8502, USA
    Science 346:1486-92. 2014
    ..signaling protein (MAVS)-dependent RNA sensing pathway or reverse-transcribed and detected via the cGAS-cGAMP-STING pathway, triggering a second, sustained wave of signaling that promotes specific immunoglobulin M production...
  35. doi DNA damage primes the type I interferon system via the cytosolic DNA sensor STING to promote anti-microbial innate immunity
    Anetta Hartlova
    Laboratory for Molecular Infection Medicine Sweden, Umea University, 90 187 Umeå, Sweden Department of Molecular Biology, Umea University, 90 187 Umeå, Sweden Umeå Centre for Microbial Research, Umea University, 90 187 Umeå, Sweden
    Immunity 42:332-43. 2015
    ..system by DNA damage involved release of DNA into the cytoplasm where it activated the cytosolic DNA sensing STING-mediated pathway, which in turn enhanced responses to innate stimuli by activating the expression of Toll-like ..
  36. pmc PPM1A regulates antiviral signaling by antagonizing TBK1-mediated STING phosphorylation and aggregation
    Zexing Li
    State Key Laboratory of Biomembrane and Membrane Biotechnology, Chinese Academy of Sciences, Chaoyang District, Beijing, China
    PLoS Pathog 11:e1004783. 2015
    Stimulator of interferon genes (STING, also known as MITA and ERIS) is critical in protecting the host against DNA pathogen invasion. However, the molecular mechanism underlying the regulation of STING remains unclear...
  37. pmc STING Negatively Regulates Double-Stranded DNA-Activated JAK1-STAT1 Signaling via SHP-1/2 in B Cells
    Guanjun Dong
    The State Key Laboratory of Pharmaceutical Biotechnology, Division of Immunology, Medical School, Nanjing University, Nanjing 210093, China
    Mol Cells 38:441-51. 2015
    ..The stimulator of interferon genes protein (STING) has been demonstrated to be a critical hub of type I IFN induction in cytosolic DNA-..
  38. pmc Cutting Edge: cGAS Is Required for Lethal Autoimmune Disease in the Trex1-Deficient Mouse Model of Aicardi-Goutières Syndrome
    Elizabeth E Gray
    Department of Immunology, University of Washington School of Medicine, Seattle, WA 98195
    J Immunol 195:1939-43. 2015
    ..These findings implicate cGAS as a key driver of autoimmune disease and suggest that cGAS inhibitors may be useful therapeutics for Aicardi-Goutières syndrome and related autoimmune diseases...
  39. pmc Cytosolic Nuclease TREX1 Regulates Oligosaccharyltransferase Activity Independent of Nuclease Activity to Suppress Immune Activation
    Maroof Hasan
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Immunity 43:463-74. 2015
    ..This function of the TREX1 C terminus suggests a potential therapeutic option for TREX1-fs mutant-associated diseases. ..
  40. pmc Isoforms of RNA-Editing Enzyme ADAR1 Independently Control Nucleic Acid Sensor MDA5-Driven Autoimmunity and Multi-organ Development
    Kathleen Pestal
    Department of Immunology, University of Washington School of Medicine, Seattle, WA 98195, USA
    Immunity 43:933-44. 2015
    ..Our findings delineate genetically separable roles for both ADAR1 isoforms in vivo, with implications for the human diseases caused by ADAR mutations. ..
  41. pmc Rat and human STINGs profile similarly towards anticancer/antiviral compounds
    Heng Zhang
    State Key Laboratory of Protein and Plant Gene Research, and Biodynamic Optical Imaging Center BIOPIC, School of Life Sciences, Peking University, Beijing 100871, China
    Sci Rep 5:18035. 2015
    Cyclic dinucleotides (CDNs) and antitumor/antiviral agents (DMXAA and CMA) trigger STING-dependent innate immunity activation...
  42. pmc Cutting Edge: Novel Tmem173 Allele Reveals Importance of STING N Terminus in Trafficking and Type I IFN Production
    Guy Surpris
    Program in Immunology, Tufts University, Boston, MA 02111
    J Immunol 196:547-52. 2016
    With the stimulator of IFN genes (STING) C terminus being extensively studied, the role of the N-terminal domain (NTD) of STING remains an important subject of investigation...
  43. pmc Influenza A virus targets a cGAS-independent STING pathway that controls enveloped RNA viruses
    Christian K Holm
    Department of Biomedicine, Aarhus University, Aarhus 8000, Denmark
    Nat Commun 7:10680. 2016
    Stimulator of interferon genes (STING) is known be involved in control of DNA viruses but has an unexplored role in control of RNA viruses...
  44. pmc Antagonism of the STING Pathway via Activation of the AIM2 Inflammasome by Intracellular DNA
    Leticia Corrales
    Department of Pathology, The University of Chicago, Chicago, IL 60637
    J Immunol 196:3191-8. 2016
    Recent evidence has indicated that innate immune sensing of cytosolic DNA in dendritic cells via the host STING pathway is a major mechanism leading to spontaneous T cell responses against tumors...
  45. pmc NLRX1 Sequesters STING to Negatively Regulate the Interferon Response, Thereby Facilitating the Replication of HIV-1 and DNA Viruses
    Haitao Guo
    Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Cell Host Microbe 19:515-28. 2016
    ..NLRX1 sequesters the DNA-sensing adaptor STING from interaction with TANK-binding kinase 1 (TBK1), which is a requisite for IFN-1 induction in response to DNA...
  46. pmc The AIM2-like Receptors Are Dispensable for the Interferon Response to Intracellular DNA
    Elizabeth E Gray
    Department of Immunology, University of Washington School of Medicine, Seattle, WA, 98195, USA
    Immunity 45:255-66. 2016
    Detection of intracellular DNA triggers activation of the STING-dependent interferon-stimulatory DNA (ISD) pathway, which is essential for antiviral responses...
  47. pmc Adenovirus detection by the cGAS/STING/TBK1 DNA sensing cascade
    Eric Lam
    Weill Medical College of Cornell University, Department of Microbiology and Immunology, Molecular Biology Graduate Program, New York, New York, USA
    J Virol 88:974-81. 2014
    ..GMP-AMP synthase (cGAS), a DNA sensor that produces a cyclic guanine-adenine dinucleotide (cGAMP) inducer of STING, has been examined to determine its role in generating an antiadenoviral response...
  48. pmc STING-IRF3 pathway links endoplasmic reticulum stress with hepatocyte apoptosis in early alcoholic liver disease
    Jan Petrasek
    Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605
    Proc Natl Acad Sci U S A 110:16544-9. 2013
    ..induced ER stress and triggered the association of IRF3 with the ER adaptor, stimulator of interferon genes (STING), as well as subsequent phosphorylation of IRF3...
  49. pmc Cutting edge: DNA sensing via the STING adaptor in myeloid dendritic cells induces potent tolerogenic responses
    Lei Huang
    Cancer Immunology, Inflammation and Tolerance Program, Cancer Center, Augusta, GA 30912
    J Immunol 191:3509-13. 2013
    Cytosolic DNA sensing via the stimulator of IFN genes (STING) adaptor incites autoimmunity by inducing type I IFN (IFN-αβ). In this study, we show that DNA is also sensed via STING to suppress immunity by inducing IDO...
  50. pmc Species-specific detection of the antiviral small-molecule compound CMA by STING
    Taner Cavlar
    Unit for Clinical Biochemistry, Institute for Clinical Chemistry and Clinical Pharmacology, University Hospital, University of Bonn, Bonn, Germany
    EMBO J 32:1440-50. 2013
    ..Here we demonstrate that CMA mediates a cell-intrinsic type I IFN response, depending on the ER-resident protein STING. CMA directly binds to STING and triggers a strong antiviral response through the TBK1/IRF3 route...
  51. pmc The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I interferon immune response
    Kislay Parvatiyar
    Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, Los Angeles, California, USA
    Nat Immunol 13:1155-61. 2012
    ..cyclic di-GMP (c-di-GMP) or cyclic di-AMP (c-di-AMP) is dependent on a signaling axis that involves the adaptor STING, the kinase TBK1 and the transcription factor IRF3...
  52. pmc Innate immune response induced by baculovirus attenuates transgene expression in mammalian cells
    Chikako Ono
    Department of Molecular Virology, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan
    J Virol 88:2157-67. 2014
    ..transduction by the recombinant baculovirus was achieved in MEFs deficient for stimulator of interferon genes (STING), TANK binding kinase 1 (TBK1), IFN regulatory factor 3 (IRF3), or IFN-β promoter stimulator 1 (IPS-1), but not ..
  53. pmc STING manifests self DNA-dependent inflammatory disease
    Jeonghyun Ahn
    Department of Cell Biology and Sylvester Comprehensive Cancer Center, University of Miami School of Medicine, Miami, FL 33136, USA
    Proc Natl Acad Sci U S A 109:19386-91. 2012
    ..However, we report here that Stimulator of IFN Genes (STING) is responsible for inflammation-related embryonic death in DNase II defective mice initiated by self DNA...
  54. doi Streptococcus pneumoniae stimulates a STING- and IFN regulatory factor 3-dependent type I IFN production in macrophages, which regulates RANTES production in macrophages, cocultured alveolar epithelial cells, and mouse lungs
    Uwe Koppe
    Department of Internal Medicine Infectious Diseases and Pulmonary Medicine, Charite University Medicine Berlin, 13353 Berlin, Germany
    J Immunol 188:811-7. 2012
    ..toxin pneumolysin and appeared to be mediated by a cytosolic DNA-sensing pathway involving the adapter molecule STING and the transcription factor IFN regulatory factor 3...
  55. pmc Virus-cell fusion as a trigger of innate immunity dependent on the adaptor STING
    Christian K Holm
    Department of Biomedicine, Aarhus University, Aarhus, Denmark
    Nat Immunol 13:737-43. 2012
    ..The fusion-dependent response was dependent on the stimulator of interferon genes STING but was independent of DNA, RNA and viral capsid...
  56. pmc LSm14A is a processing body-associated sensor of viral nucleic acids that initiates cellular antiviral response in the early phase of viral infection
    Ying Li
    State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China
    Proc Natl Acad Sci U S A 109:11770-5. 2012
    ..We further found that LSm14A-mediated IFN-β induction requires RIG-I-VISA or MITA after RNA or DNA virus infection, respectively, and viral infection causes translocation of LSm14A to peroxisomes, ..
  57. pmc TRIF licenses caspase-11-dependent NLRP3 inflammasome activation by gram-negative bacteria
    Vijay A K Rathinam
    Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Cell 150:606-19. 2012
    ..The identification of TRIF as a regulator of caspase-11 underscores the importance of TLRs as master regulators of inflammasomes during Gram-negative bacterial infection...
  58. pmc Crystallization studies of the murine c-di-GMP sensor protein STING
    Yi Che Su
    Institute of Biochemistry, National Chung Hsing University, Taichung 40227, Taiwan
    Acta Crystallogr Sect F Struct Biol Cryst Commun 68:906-10. 2012
    ..Recently, the mammalian ER membrane protein STING (stimulator of IFN genes; also known as MITA, ERIS, MPYS and TMEM173) has been found to be the master regulator linking the detection of cytosolic DNA to TANK-binding kinase 1 (TBK1) ..
  59. pmc 5,6-Dimethylxanthenone-4-acetic acid (DMXAA) activates stimulator of interferon gene (STING)-dependent innate immune pathways and is regulated by mitochondrial membrane potential
    Daniel Prantner
    Department of Microbiology and Immunology, University of Maryland, School of Medicine UMB, Baltimore, Maryland 21201, USA
    J Biol Chem 287:39776-88. 2012
    ..in response to DMXAA in mouse macrophages requires the mitochondrial and endoplasmic reticulum resident protein STING. Addition of the antioxidant diphenylene iodonium (DPI) diminished DMXAA-induced IFN-β, but this decrease was ..
  60. pmc Endoplasmic reticulum stress regulates the innate immunity critical transcription factor IRF3
    Yi Ping Liu
    Department of Pediatrics, School of Medicine and Public Health, University of Wisconsin, Madison, WI 53792, USA
    J Immunol 189:4630-9. 2012
    ..Our results also suggest certain types of ER stress accomplish IRF3 phosphorylation by co-opting existing innate immune pathogen response pathways. These data have implications for diseases involving ER stress and type I IFN...
  61. pmc Extensive evolutionary and functional diversity among mammalian AIM2-like receptors
    Rebecca L Brunette
    Department of Immunology, University of Washington School of Medicine, Seattle, WA 98195, USA
    J Exp Med 209:1969-83. 2012
    ..Detection of intracellular DNA activates STING-dependent type I interferons (IFNs) and the ASC-dependent inflammasome...
  62. pmc DENV inhibits type I IFN production in infected cells by cleaving human STING
    Sebastian Aguirre
    Department of Microbiology and the Global Health and Emerging Pathogens Institute, Mount Sinai School of Medicine, New York City, New York, United States of America
    PLoS Pathog 8:e1002934. 2012
    ..In the present report we identify the human adaptor molecule STING as a target of the NS2B3 protease complex...
  63. pmc DNA-PK is a DNA sensor for IRF-3-dependent innate immunity
    Brian J Ferguson
    Department of Virology, Imperial College London, London, United Kingdom Department of Pathology, University of Cambridge, Cambridge, United Kingdom
    elife 1:e00047. 2012
    ..dependent on IFN regulatory factor 3 (IRF-3), TANK-binding kinase 1 (TBK1) and stimulator of interferon genes (STING)...
  64. pmc STING/MPYS mediates host defense against Listeria monocytogenes infection by regulating Ly6C(hi) monocyte migration
    Lei Jin
    Integrated Department of Immunology, University of Colorado Denver School of Medicine and National Jewish Health, Denver, CO 80206, USA
    J Immunol 190:2835-43. 2013
    MPYS (also known as STING, MITA, and TMEM173) is a type I IFN stimulator that is essential for host defense against DNA virus infection and appears important in defense against certain bacteria...
  65. pmc DNA damage sensor MRE11 recognizes cytosolic double-stranded DNA and induces type I interferon by regulating STING trafficking
    Takeshi Kondo
    Laboratory of Host Defense, World Premier International Research Center Initiative WPI Immunology Frontier Research Center, Osaka University, Osaka 565 0871, Japan
    Proc Natl Acad Sci U S A 110:2969-74. 2013
    ..physically interacted with dsDNA in the cytoplasm and was required for activation of stimulator of IFN genes (STING) and IRF3...
  66. pmc Interferon-γ and granulocyte/monocyte colony-stimulating factor production by natural killer cells involves different signaling pathways and the adaptor stimulator of interferon genes (STING)
    Fernando Souza-Fonseca-Guimarães
    Institut Pasteur, Unit of Cytokines and Inflammation, Department Infection et Epidémiologie, 28 rue du Dr Roux, F 75015 Paris, France
    J Biol Chem 288:10715-21. 2013
    ..IFN-γ production was found to be MyD88- and TLR9-dependent, whereas GM-CSF was TLR9-independent but dependent on STING (stimulator of interferon genes), a cytosolic adaptor recently described for DNA sensing...
  67. doi Novel c-di-GMP recognition modes of the mouse innate immune adaptor protein STING
    Ko Hsin Chin
    Agricultural Biotechnology Center, National Chung Hsing University, Taichung 40227, Taiwan
    Acta Crystallogr D Biol Crystallogr 69:352-66. 2013
    The mammalian ER protein STING (stimulator of interferon genes; also known as MITA, ERIS, MPYS or TMEM173) is an adaptor protein that links the detection of cytosolic dsDNA to the activation of TANK-binding kinase 1 (TBK1) and its ..
  68. pmc Mouse, but not human STING, binds and signals in response to the vascular disrupting agent 5,6-dimethylxanthenone-4-acetic acid
    Joseph Conlon
    Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    J Immunol 190:5216-25. 2013
    ..In this study, we identify stimulator of IFN gene (STING) as a direct receptor for DMXAA leading to TANK-binding kinase 1 and IFN regulatory factor 3 signaling...
  69. pmc MyD88 and STING signaling pathways are required for IRF3-mediated IFN-β induction in response to Brucella abortus infection
    Leonardo A de Almeida
    Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte Minas Gerais, Brazil
    PLoS ONE 6:e23135. 2011
    ..a mechanism dependent on RNA polymerase III to be sensed probably by an unknown receptor via the adaptor molecule STING. Finally, we have demonstrated that IFN-αβR KO mice are more resistant to infection suggesting that type I IFN ..
  70. pmc Cellular reactive oxygen species inhibit MPYS induction of IFNβ
    Lei Jin
    Integrated Department of Immunology, University of Colorado Denver School of Medicine and National Jewish Health, Denver, Colorado, United States of America
    PLoS ONE 5:e15142. 2010
    ..Here we report that MPYS, a.k.a. STING, which was recently shown to mediate activation of IFNβ expression during infection, is a ROS sensor...
  71. doi The ubiquitin ligase TRIM56 regulates innate immune responses to intracellular double-stranded DNA
    Tetsuo Tsuchida
    Laboratory of Host Defense, WPI Immunology Frontier Research Center, Osaka University, Osaka 565 0871, Japan
    Immunity 33:765-76. 2010
    ..TRIM56 interacted with STING and targeted it for lysine 63-linked ubiquitination...

Patents1

  1. NF-kB activating gene
    Patent Number: WO03048202-A2; Date:2003-06-12