Tlr8

Summary

Gene Symbol: Tlr8
Description: toll-like receptor 8
Alias: toll-like receptor 8
Species: mouse

Top Publications

  1. pmc A five-amino-acid motif in the undefined region of the TLR8 ectodomain is required for species-specific ligand recognition
    Jin Liu
    Immunology Program, Sidney Kimmel Cancer Center, San Diego, CA 92121, USA
    Mol Immunol 47:1083-90. 2010
  2. ncbi High-throughput engineering of the mouse genome coupled with high-resolution expression analysis
    David M Valenzuela
    Regeneron Pharmaceuticals, Inc, 777 Old Saw Mill Road, Tarrytown, New York 10591, USA
    Nat Biotechnol 21:652-9. 2003
  3. pmc TLR8 deficiency leads to autoimmunity in mice
    Olivier Demaria
    Centre d immunologie de Marseille Luminy, Universite de la Mediterranee, Marseille, France
    J Clin Invest 120:3651-62. 2010
  4. pmc Toll-like receptor 8-mediated activation of murine plasmacytoid dendritic cells by vaccinia viral DNA
    Jennifer Martinez
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 107:6442-7. 2010
  5. doi Recognition of nucleic acid and nucleic acid analogs by Toll-like receptors 7, 8 and 9
    Stefan Bauer
    Institut fur Immunology, Philipps Universitat Marburg, BMFZ, Hans Meerweinstr 2, 35043 Marburg, Germany
    Immunobiology 213:315-28. 2008
  6. ncbi Identification of RNA sequence motifs stimulating sequence-specific TLR8-dependent immune responses
    Alexandra Forsbach
    Coley Pharmaceutical GmbH, Dusseldorf, Germany
    J Immunol 180:3729-38. 2008
  7. pmc Toll-like receptor 8 functions as a negative regulator of neurite outgrowth and inducer of neuronal apoptosis
    Yinghua Ma
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
    J Cell Biol 175:209-15. 2006
  8. ncbi Cutting edge: activation of murine TLR8 by a combination of imidazoquinoline immune response modifiers and polyT oligodeoxynucleotides
    Keith K B Gorden
    Department of Pharmacology, 3M Pharmaceuticals, St Paul, MN 55144, USA
    J Immunol 177:6584-7. 2006
  9. ncbi Human TLR7 or TLR8 independently confer responsiveness to the antiviral compound R-848
    Marion Jurk
    Nat Immunol 3:499. 2002
  10. ncbi Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8
    Florian Heil
    Institute of Medical Microbiology, Immunology and Hygiene, Technische Universitat Munchen, Trogerstr 9, D 81675 Munich, Germany
    Science 303:1526-9. 2004

Scientific Experts

  • Holly R Chinnery
  • L Alexopoulou
  • P Dasari
  • Stefan Bauer
  • Fei Mao
  • Weiwen Jiang
  • Olivier Demaria
  • Tingting Li
  • Hermann Wagner
  • Stephanie Jung
  • J J Ignatz-Hoover
  • Ngoc Lan Tran
  • Leonhard X Heinz
  • Benjamin R Umiker
  • Soroush T Sarvestani
  • Saleh Al-Quraishy
  • William T Festuccia
  • Jessica M Snyder
  • Junpei Kimura
  • Benoit Desnues
  • Alfred C Aplin
  • Sung Chun Tang
  • Mayte Suárez-Fariñas
  • David M Valenzuela
  • Hsin Yu Liu
  • Takahiro Asami
  • Melissa A Cunningham
  • David Kaul
  • Gavin W Porter
  • Jia Qi
  • Kathrin Kastenmüller
  • Min Du
  • Marion Jurk
  • Mattias Enoksson
  • Florian Heil
  • Daniel Mitchell
  • Jin Liu
  • Juliana Bessa
  • Jennifer Martinez
  • Scott M Vanderwerf
  • Alexandra Forsbach
  • Andrew J Murphy
  • George D Yancopoulos
  • Yinghua Ma
  • Jinzhong Qin
  • Keith K B Gorden
  • Jianyong Wang
  • Shizuo Akira
  • Arthur M Krieg
  • Jorg Vollmer
  • Guohua Chen
  • Xiaobing He
  • Shuang Zeng
  • Grayson Lipford
  • Huaijie Jia
  • Qiwang Jin
  • Yongxiang Fang
  • Zhizhong Jing
  • Christoph L Baumann
  • Berend Snijder
  • Jacques Colinge
  • Giulio Superti-Furga
  • Florian P Breitwieser
  • Marie Laure Santiago-Raber
  • K Sun
  • Omar Sharif
  • Manuele Rebsamen
  • Thomas Karonitsch
  • Andreas Pichlmair
  • Marielle S Köberlin
  • K Gupta
  • Tina von Thülen
  • D N Wald
  • Céline Manzin-Lorenzi
  • Stephanie Pigisch
  • Manuela Bruckner
  • Andreas Kaufmann
  • A Chakrabarti
  • Keiryn L Bennett
  • Viktoria Laukemper
  • Sylvia Knapp
  • Guanghou Shui
  • André C Müller
  • Markus R Wenk
  • M K Agarwal
  • Stephan Blüml
  • Irene M Aspalter
  • Riem Gawish
  • Richard K Kandasamy
  • H Wang

Detail Information

Publications44

  1. pmc A five-amino-acid motif in the undefined region of the TLR8 ectodomain is required for species-specific ligand recognition
    Jin Liu
    Immunology Program, Sidney Kimmel Cancer Center, San Diego, CA 92121, USA
    Mol Immunol 47:1083-90. 2010
    Toll-like receptors play important roles in regulating immunity against microbial infections. Toll-like receptor 8 (TLR8) belongs to a subfamily comprising TLR7, TLR8 and TLR9...
  2. ncbi High-throughput engineering of the mouse genome coupled with high-resolution expression analysis
    David M Valenzuela
    Regeneron Pharmaceuticals, Inc, 777 Old Saw Mill Road, Tarrytown, New York 10591, USA
    Nat Biotechnol 21:652-9. 2003
    ..5-1.0% of the entire genome. We also provide dozens of informative expression patterns involving cells in the nervous system, immune system, vasculature, skeleton, fat and other tissues...
  3. pmc TLR8 deficiency leads to autoimmunity in mice
    Olivier Demaria
    Centre d immunologie de Marseille Luminy, Universite de la Mediterranee, Marseille, France
    J Clin Invest 120:3651-62. 2010
    ..However, the function of TLR8 is largely unknown. In the current study, we investigated the role of TLR8 signaling in immunity in mice...
  4. pmc Toll-like receptor 8-mediated activation of murine plasmacytoid dendritic cells by vaccinia viral DNA
    Jennifer Martinez
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 107:6442-7. 2010
    ..Using HEK293 cells transfected with murine TLR7 or TLR8 and a NF-kappaB luciferase reporter, we demonstrated that stimulation of TLR8-, but not TLR7-, transfected cells ..
  5. doi Recognition of nucleic acid and nucleic acid analogs by Toll-like receptors 7, 8 and 9
    Stefan Bauer
    Institut fur Immunology, Philipps Universitat Marburg, BMFZ, Hans Meerweinstr 2, 35043 Marburg, Germany
    Immunobiology 213:315-28. 2008
    ..However, a role in the generation or perpetuation of autoimmune diseases such as systemic lupus erythematosus (SLE) has also been suggested...
  6. ncbi Identification of RNA sequence motifs stimulating sequence-specific TLR8-dependent immune responses
    Alexandra Forsbach
    Coley Pharmaceutical GmbH, Dusseldorf, Germany
    J Immunol 180:3729-38. 2008
    ..single-stranded RNA sequences containing defined sequence motifs that either preferentially activate human TLR8-mediated as opposed to TLR7- or TLR7/8-mediated immune responses...
  7. pmc Toll-like receptor 8 functions as a negative regulator of neurite outgrowth and inducer of neuronal apoptosis
    Yinghua Ma
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA
    J Cell Biol 175:209-15. 2006
    ..We report that TLR8 is dynamically expressed during mouse brain development and localizes to neurons and axons...
  8. ncbi Cutting edge: activation of murine TLR8 by a combination of imidazoquinoline immune response modifiers and polyT oligodeoxynucleotides
    Keith K B Gorden
    Department of Pharmacology, 3M Pharmaceuticals, St Paul, MN 55144, USA
    J Immunol 177:6584-7. 2006
    Synthetic immune response modifiers (IRM) such as imidazoquinolines can selectively activate human TLR7 or TLR8. Although these endosomal TLRs are close relatives, TLR7-deficient mice are unresponsive to TLR8 agonist IRMs...
  9. ncbi Human TLR7 or TLR8 independently confer responsiveness to the antiviral compound R-848
    Marion Jurk
    Nat Immunol 3:499. 2002
  10. ncbi Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8
    Florian Heil
    Institute of Medical Microbiology, Immunology and Hygiene, Technische Universitat Munchen, Trogerstr 9, D 81675 Munich, Germany
    Science 303:1526-9. 2004
    ..By using Toll-like receptor (TLR)-deficient mice and genetic complementation, we show that murine TLR7 and human TLR8 mediate species-specific recognition of GU-rich ssRNA...
  11. doi Regulation of angiogenesis, mural cell recruitment and adventitial macrophage behavior by Toll-like receptors
    Alfred C Aplin
    Department of Pathology, University of Washington, Seattle, WA, USA
    Angiogenesis 17:147-61. 2014
    ..These results suggest that the TLR system participates in the angiogenic response of the vessel wall to injury and may play an important role in the regulation of inflammatory angiogenesis in reactive and pathologic processes. ..
  12. pmc Modulation of murine macrophage TLR7/8-mediated cytokine expression by mesenchymal stem cell-conditioned medium
    Takahiro Asami
    Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Mediators Inflamm 2013:264260. 2013
    ..is known about the effect of MSCs or their secretions on the ligand response of Toll-like receptor (TLR) 7 and TLR8, receptors that recognize viral single-stranded RNA (ssRNA)...
  13. doi Evidence for a detrimental role of TLR8 in ischemic stroke
    Sung Chun Tang
    Stroke Center, Department of Neurology, National Taiwan University Hospital, Taipei, Taiwan
    Exp Neurol 250:341-7. 2013
    ..However, relatively little is known about the role of TLR8 in ischemic stroke...
  14. pmc Inosine-mediated modulation of RNA sensing by Toll-like receptor 7 (TLR7) and TLR8
    Soroush T Sarvestani
    Centre for Cancer Research, Monash Institute of Medical Research, Monash University, Clayton, Victoria, Australia
    J Virol 88:799-810. 2014
    ..Our results suggest a novel function of A-to-I RNA editing, which is to facilitate TLR7/8 sensing of phagocytosed viral RNA. ..
  15. pmc Suppression of molecular inflammatory pathways by Toll-like receptor 7, 8, and 9 antagonists in a model of IL-23-induced skin inflammation
    Mayte Suárez-Fariñas
    Laboratory for Investigative Dermatology, The Rockefeller University, New York, New York, United States of America Center for Clinical and Translational Science, The Rockefeller University, New York, New York, United States of America
    PLoS ONE 8:e84634. 2013
    ....
  16. pmc TLR8 on dendritic cells and TLR9 on B cells restrain TLR7-mediated spontaneous autoimmunity in C57BL/6 mice
    Benoit Desnues
    Centre d immunologie de Marseille Luminy, Aix Marseille University UM 2, 13288 Marseille, France
    Proc Natl Acad Sci U S A 111:1497-502. 2014
    ..Toll-like receptor (TLR)7, TLR8, and TLR9 sense microbial or endogenous nucleic acids and are implicated in the development of SLE...
  17. pmc Dosage of X-linked Toll-like receptor 8 determines gender differences in the development of systemic lupus erythematosus
    Benjamin R Umiker
    Program in Immunology, Sackler School of Graduate Biomedical Sciences, Tufts University School of Medicine, Boston, MA, USA Department of Integrative Physiology and Pathobiology, Tufts University School of Medicine, Boston, MA, USA
    Eur J Immunol 44:1503-16. 2014
    ..Autoantibody was produced in mice with single deletions of Tlr7, Tlr8, or Tlr9 or combined deletions of Tlr7 and Tlr9...
  18. pmc Myeloid-specific Rictor deletion induces M1 macrophage polarization and potentiates in vivo pro-inflammatory response to lipopolysaccharide
    William T Festuccia
    Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, Brazil
    PLoS ONE 9:e95432. 2014
    ..These observations suggest that approaches aimed at modulating mTORC2 activity may represent a possible therapeutic approach for diseases linked to excessive inflammation...
  19. doi Testosterone persistently dysregulates hepatic expression of Tlr6 and Tlr8 induced by Plasmodium chabaudi malaria
    Saleh Al-Quraishy
    Department of Zoology, College of Science, King Saud University, P O Box 2455, Riyadh, 11451, Saudi Arabia
    Parasitol Res 113:3609-20. 2014
    ..Our data reveal that T induces a 9.1-fold downregulation of Tlr6 mRNA and 6.3-fold upregulation of Tlr8 mRNA...
  20. pmc Humanized TLR7/8 expression drives proliferative multisystemic histiocytosis in C57BL/6 mice
    Jessica M Snyder
    Department of Comparative Medicine, University of Washington, Seattle, Washington, United States of America Comparative Pathology Program, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 9:e107257. 2014
    A humanized TLR7/TLR8 transgenic mouse line was engineered for studies using TLR7/8 ligands as vaccine adjuvants...
  21. pmc Molecular cloning and functional characterization of murine toll‑like receptor 8
    Tingting Li
    State Key Laboratory of Veterinary Etiological Biology, Key Laboratory of Veterinary Public Health of Ministry of Agriculture, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu 730046, P R China
    Mol Med Rep 13:1119-26. 2016
    ..b>TLR8 is a member of several endosome nucleic acid-sensing TLRs; however little attention has been paid to murine TLR8 (..
  22. pmc The role of TLR8 signaling in acute myeloid leukemia differentiation
    J J Ignatz-Hoover
    Department of Pathology, Case Western Reserve University, Cleveland, OH, USA
    Leukemia 29:918-26. 2015
    ..We present evidence that the TLR8 activation promotes AML differentiation and growth inhibition in a TLR8/MyD88/p38-dependent manner...
  23. doi TLR9 and TLR7/8 activation induces formation of keratic precipitates and giant macrophages in the mouse cornea
    Holly R Chinnery
    Department of Optometry and Vision Sciences, University of Melbourne, Victoria, Australia Department of Anatomy and Developmental Biology, Monash University, Victoria, Australia School of Molecular Sciences, Department of Biochemistry, La Trobe Institute for Molecular Science, La Trobe University, Bundoora, Australia Department of Ophthalmology, Institute of Medical Sciences, University of Aberdeen, United Kingdom and Ocular Immunology Program, Centre for Ophthalmology and Visual Science, The University of Western Australia, Perth, Australia
    J Leukoc Biol 97:103-10. 2015
    ..We suggest that giant cell formation, which is a characteristic feature of granuloma formation in many tissues, may be a unique feature of TLR9- and TLR7/8-mediated macrophage activation. ..
  24. pmc Toll-like receptor 8 deletion accelerates autoimmunity in a mouse model of lupus through a Toll-like receptor 7-dependent mechanism
    Ngoc Lan Tran
    Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Geneva, Switzerland
    Immunology 145:60-70. 2015
    ..In contrast, very little is known about endogenous TLR8 activation in mice. We therefore tested whether TLR8 could affect autoimmune responses in a murine model of lupus...
  25. pmc Overexpression of Toll-like receptor 8 correlates with the progression of podocyte injury in murine autoimmune glomerulonephritis
    Junpei Kimura
    Laboratory of Anatomy, Department of Biomedical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan
    Sci Rep 4:7290. 2014
    ..In particular, the expression of Tlr8 and its downstream cytokines was markedly increased...
  26. pmc The Lipid-Modifying Enzyme SMPDL3B Negatively Regulates Innate Immunity
    Leonhard X Heinz
    CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, 1090 Vienna, Austria
    Cell Rep 11:1919-28. 2015
    ..Taken together, our results identify the membrane-modulating enzyme SMPDL3B as a negative regulator of TLR signaling that functions at the interface of membrane biology and innate immunity...
  27. pmc A single naturally occurring 2'-O-methylation converts a TLR7- and TLR8-activating RNA into a TLR8-specific ligand
    Stephanie Jung
    Institut fur Immunologie, Philipps Universitat Marburg, BMFZ, Marburg, Germany
    PLoS ONE 10:e0120498. 2015
    TLR7 and TLR8 recognize RNA from pathogens and lead to subsequent immune stimulation...
  28. doi A Toll-like receptor 7, 8, and 9 antagonist inhibits Th1 and Th17 responses and inflammasome activation in a model of IL-23-induced psoriasis
    Weiwen Jiang
    Idera Pharmaceuticals, Cambridge, Massachusetts 02139, USA
    J Invest Dermatol 133:1777-84. 2013
    ..The antagonist has the potential for the treatment of psoriasis and other autoimmune diseases...
  29. doi TLR7 negatively regulates dendrite outgrowth through the Myd88-c-Fos-IL-6 pathway
    Hsin Yu Liu
    Graduate Institute of Life Sciences, National Defense Medical Center, Taipei 114, Taiwan, Republic of China
    J Neurosci 33:11479-93. 2013
    ..Although both TLR7 and TLR8 recognize single-stranded RNA (ssRNA), the results of quantitative reverse transcription-PCR suggested that TLR7 is ..
  30. pmc Expression of Toll-like receptors in the developing brain
    David Kaul
    Department of Neurology, Charite Universitaetsmedizin Berlin, Berlin, Germany
    PLoS ONE 7:e37767. 2012
    ..In contrast, expression of TLR1-6, TLR8, MyD88, and TRIF mRNA displayed no significant changes in the different phases of brain development...
  31. pmc Estrogen receptor alpha modulates Toll-like receptor signaling in murine lupus
    Melissa A Cunningham
    Medical University of South Carolina, Division of Rheumatology and Immunology and Ralph H Johnson Veterans Affairs Hospital, Charleston, SC 29425, USA
    Clin Immunol 144:1-12. 2012
    ....
  32. doi [Toll-like receptor 8: the awkward TLR]
    Lena Alexopoulou
    Centre d immunologie de Marseille Luminy, Aix Marseille Universite, Case 906, 13288 Marseille Cedex 9, France
    Med Sci (Paris) 28:96-102. 2012
    ..TLR1 to TLR9 are common in mice and humans and recognize similar ligands in both species, with the exception of TLR8. Human TLR7 and TLR8 and mouse TLR7 detect viral single-stranded RNA and imidazoquinoline compounds, while mouse ..
  33. pmc TLR agonists downregulate H2-O in CD8alpha- dendritic cells
    Gavin W Porter
    Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    J Immunol 187:4151-60. 2011
    ....
  34. ncbi TLR8-mediated NF-kappaB and JNK activation are TAK1-independent and MEKK3-dependent
    Jinzhong Qin
    Department of Immunology, Cleveland Clinic Foundation, Ohio 44195, USA
    J Biol Chem 281:21013-21. 2006
    b>TLR8-mediated NF-kappaB and IRF7 activation are abolished in human IRAK-deficient 293 cells and IRAK4-deficient fibroblast cells...
  35. ncbi The functional effects of physical interactions among Toll-like receptors 7, 8, and 9
    Jianyong Wang
    Department of Pharmacology, 3M Pharmaceutical Division, St Paul, Minnesota 55144, USA
    J Biol Chem 281:37427-34. 2006
    ..The other TLRs that are evolutionarily closely related and highly homologous are TLR7, TLR8, and TLR9...
  36. ncbi Toll-like receptors
    P Dasari
    Child Health Research Institute, Women s and Children s Hospital, Adelaide, Australia
    J Biol Regul Homeost Agents 22:17-26. 2008
    ..Some of ten toll-like receptors identified in humans are able to recognise several pathogen-associated molecular patterns...
  37. ncbi [The expression of Toll-like receptor 8 and cytokines in rheumatoid arthritis mice induced by chicken II collogen]
    Fei Mao
    School of Medical Science and Laboratory Medicine, Jiangsu University, Zhenjiang 212013, China
    Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 25:312-4, 318. 2009
    To explore the expression of Toll-like receptor 8(TLR8)in rheumatoid arthritis induced by chicken II collogen in mice and analyze the relation of TLR8 to IL-10, IL-17A and IL-1beta.
  38. pmc TLR8-dependent TNF-(alpha) overexpression in Fanconi anemia group C cells
    Scott M Vanderwerf
    Department of Biochemistry and Molecular Biology, Oregon Health and Science University, Portland, OR 97239, USA
    Blood 114:5290-8. 2009
    ..Finding that Toll-like receptor 8 (TLR8) was one of the proteins ubiquitinylated only in mutant cells, we confirmed that TLR8 (or a TLR8-associated protein)..
  39. doi Cutting edge: IL-21 and TLR signaling regulate germinal center responses in a B cell-intrinsic manner
    Juliana Bessa
    Cytos Biotechnology, Wagistrasse 25, Schlieren 8952, Switzerland
    J Immunol 184:4615-9. 2010
    ..Hence, IL-21 acts directly on B cells and cooperates with TLR signaling for optimal B cell responses...
  40. doi Regulation of Toll-like receptor-induced chemokine production in murine dendritic cells by mitogen-activated protein kinases
    Daniel Mitchell
    The Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Brisbane, Queensland 4029, Australia
    Mol Immunol 47:2065-73. 2010
    ..The chemokine response of DCs induced by TLR agonists appears complex and could have important implications for vaccine design...
  41. doi Mast cells as sensors of cell injury through IL-33 recognition
    Mattias Enoksson
    Clinical Immunology and Allergy Unit, Department of Medicine, Karolinska Institute, SE 171 76 Stockholm, Sweden
    J Immunol 186:2523-8. 2011
    ..Our findings identify IL-33 as a key danger signal released by necrotic structural cells capable of activating mast cells, thus providing novel insights concerning the role of mast cells as sensors of cell injury...
  42. pmc Painful pathways induced by TLR stimulation of dorsal root ganglion neurons
    Jia Qi
    Laboratory of Molecular Immunoregulation, Cancer and Inflammatory Program, Center for Cancer Research, National Cancer Institute Frederick, Frederick, MD 21702, USA
    J Immunol 186:6417-26. 2011
    ..Taken together, these data indicate that stimulation of peripheral neurons by TLR ligands can induce nerve pain...
  43. pmc Protective T cell immunity in mice following protein-TLR7/8 agonist-conjugate immunization requires aggregation, type I IFN, and multiple DC subsets
    Kathrin Kastenmüller
    Vaccine Research Center and Cellular Immunology Section, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USA
    J Clin Invest 121:1782-96. 2011
    ....
  44. pmc Poly-thymidine oligonucleotides mediate activation of murine glial cells primarily through TLR7, not TLR8
    Min Du
    Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, Montana, United States of America
    PLoS ONE 6:e22454. 2011
    The functional role of murine TLR8 in the inflammatory response of the central nervous system (CNS) remains unclear. Murine TLR8 does not appear to respond to human TLR7/8 agonists, due to a five amino acid deletion in the ectodomain...