Genomes and Genes
Gene Symbol: Tlr2
Description: toll-like receptor 2
Alias: Ly105, toll-like receptor 2
Publications209 found, 100 shown here
- Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4Masahiro Yamamoto
Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Japan Science and Technology Corporation, 3 1 Yamada oka, Suita, Osaka 565 0871, Japan
Nature 420:324-9. 2002..genes and the maturation of dendritic cells is observed in these mice; they also show defective response to TLR2 ligands, but not to stimuli that activate TLR3, TLR7 or TLR9...
- A mechanism for neurodegeneration induced by group B streptococci through activation of the TLR2/MyD88 pathway in microgliaSeija Lehnardt
Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
J Immunol 177:583-92. 2006..proteinaceous factor from GBS (GBS-F) induce neuronal apoptosis via the activation of murine microglia through a TLR2-dependent and MyD88-dependent pathway in vitro...
- Toll-like receptor (TLR)-2 and TLR-4 regulate inflammation, gliosis, and myelin sparing after spinal cord injuryKristina A Kigerl
Integrated Biomedical Science Graduate Program, College of Medicine, Ohio State University, Columbus, Ohio, USA
J Neurochem 102:37-50. 2007..Recent data suggest that non-pathogenic molecules released by trauma also can trigger inflammation via TLR2 and TLR4...
- Toll-like receptor 2 ligands on the staphylococcal cell wall downregulate superantigen-induced T cell activation and prevent toxic shock syndromeThu A Chau
FOCIS Centre for Clinical Immunology and Immunotherapeutics, Robarts Research Institute, London, Ontario, Canada
Nat Med 15:641-8. 2009....
- Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasisSeth Rakoff-Nahoum
Howard Hughes Medical Institute and Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06510, USA
Cell 118:229-41. 2004..These findings reveal a novel function of TLRs-control of intestinal epithelial homeostasis and protection from injury-and provide a new perspective on the evolution of host-microbial interactions...
- Microglia initiate central nervous system innate and adaptive immune responses through multiple TLRsJulie K Olson
Department of Microbiology Immunology and Interdepartmental Immunobiology Program, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
J Immunol 173:3916-24. 2004..Furthermore, stimulation of quiescent microglia with various TLR agonists, including LPS (TLR4), peptidoglycan (TLR2), polyinosinic-polycytidylic acid (TLR3), CpG DNA (TLR9), and infection with viable Theiler's murine ..
- Pivotal role for neuronal Toll-like receptors in ischemic brain injury and functional deficitsSung Chun Tang
Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD 21224, USA
Proc Natl Acad Sci U S A 104:13798-803. 2007..We now report that neurons express several TLRs, and that the levels of TLR2 and -4 are increased in neurons in response to IFN-gamma stimulation and energy deprivation...
- Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8Florian Heil
Institute of Medical Microbiology, Immunology and Hygiene, Technische Universitat Munchen, Trogerstr 9, D 81675 Munich, Germany
Science 303:1526-9. 2004..These data suggest that ssRNA represents a physiological ligand for TLR7 and TLR8...
- The matrix component biglycan is proinflammatory and signals through Toll-like receptors 4 and 2 in macrophagesLiliana Schaefer
Department of Medicine D, Interdisciplinary Center of Clinical Research, Muenster, University of Muenster, Muenster, Germany
J Clin Invest 115:2223-33. 2005..Here we show that biglycan acts in macrophages as an endogenous ligand of TLR4 and TLR2, which mediate innate immunity, leading to rapid activation of p38, ERK, and NF-kappaB and thereby stimulating the ..
- Hepatitis C core and nonstructural 3 proteins trigger toll-like receptor 2-mediated pathways and inflammatory activationAngela Dolganiuc
Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
Gastroenterology 127:1513-24. 2004..The aim of this study was to investigate the role of TLRs in innate immune cell activation by core and NS3 proteins...
- Toll-like receptor 2 controls mucosal inflammation by regulating epithelial barrier functionE Cario
Division of Gastroenterology and Hepatology, University Hospital of Essen and Medical School University of Duisburg Essen, Essen, Germany
Gastroenterology 132:1359-74. 2007..The aim of this study was to determine the functional relevance of TLR2 to control tight junction (TJ)-associated intestinal epithelial barrier integrity to balance mucosal homeostasis ..
- Collaborative induction of inflammatory responses by dectin-1 and Toll-like receptor 2Benjamin N Gantner
Department of Immunology, University of Washington, Seattle, 98103, USA
J Exp Med 197:1107-17. 2003..The data demonstrate that collaborative recognition of distinct microbial components by different classes of innate immune receptors is crucial in orchestrating inflammatory responses...
- Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall componentsO Takeuchi
Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Japan
Immunity 11:443-51. 1999..To investigate in vivo roles of TLR2, we generated TLR2-deficient mice...
- Herpes simplex virus 1 interaction with Toll-like receptor 2 contributes to lethal encephalitisEvelyn A Kurt-Jones
Department of Medicine, University of Massachusetts Medical Center, 364 Plantation Street, Lazare Research Building, Worcester, MA 01605, USA
Proc Natl Acad Sci U S A 101:1315-20. 2004..Here, we demonstrate that TLR2 mediates the inflammatory cytokine response to HSV-1 by using both transfected cell lines and knockout mice...
- Syk kinase is required for collaborative cytokine production induced through Dectin-1 and Toll-like receptorsKevin M Dennehy
Institute of Infectious Disease and Molecular Medicine, Clinical Laboratory Sciences Division of Immunology, University of Cape Town, Cape Town, South Africa
Eur J Immunol 38:500-6. 2008..fungal beta-glucan receptor, Dectin-1, which collaborates through an undefined mechanism with Toll-like receptor 2 (TLR2) to induce optimal cytokine responses in macrophages...
- Toll-like receptor 2 suppresses immunity against Candida albicans through induction of IL-10 and regulatory T cellsMihai G Netea
Department of Medicine, University Medical Center St Radboud, Nijmegen, The Netherlands
J Immunol 172:3712-8. 2004Toll-like receptor (TLR) 2 and TLR4 play a pivotal role in recognition of Candida albicans. We demonstrate that TLR2(-/-) mice are more resistant to disseminated Candida infection, and this is associated with increased chemotaxis and ..
- Regulation of lung injury and repair by Toll-like receptors and hyaluronanDianhua Jiang
Department of Medicine, Section of Pulmonary and Critical Care Medicine, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06520, USA
Nat Med 11:1173-9. 2005..Here we report that hyaluronan degradation products require MyD88 and both Toll-like receptor (TLR)4 and TLR2 in vitro and in vivo to initiate inflammatory responses in acute lung injury...
- Toll-like receptors modulate adult hippocampal neurogenesisAsya Rolls
Department of Neurobiology, The Weizmann Institute of Science, 76100 Rehovot, Israel
Nat Cell Biol 9:1081-8. 2007..We show that TLR2 and TLR4 are found on adult neural stem/progenitor cells (NPCs) and have distinct and opposing functions in NPC ..
- Cutting edge: Toll-like receptor (TLR)2- and TLR4-mediated pathogen recognition in resistance to airborne infection with Mycobacterium tuberculosisNorbert Reiling
Division of Molecular Infection Biology, Research Center Borstel, Borstel, Germany
J Immunol 169:3480-4. 2002..tuberculosis infection has remained unexplored in vivo. To address this issue, we infected mice defective in CD14, TLR2, or TLR4 with M. tuberculosis by aerosol...
- The role of toll-like receptor (TLR) 2 and TLR4 in the host defense against disseminated candidiasisMihai G Netea
Department of Medicine, Division of General Internal Medicine, University Medical Center St Radboud, Nijmegen, The Netherlands
J Infect Dis 185:1483-9. 2002..and IL-1beta production by human peripheral blood mononuclear cells was significantly inhibited by blocking anti-TLR2 antibodies in vitro. In conclusion, TLR4-defective C3H/HeJ mice are more susceptible to C...
- The contribution of the Toll-like/IL-1 receptor superfamily to innate and adaptive immunity to fungal pathogens in vivoSilvia Bellocchio
Microbiology Section, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy
J Immunol 172:3059-69. 2004..of the MyD88 adapter may occur through signaling by distinct members of the IL-1R/TLR superfamily, including IL-1R, TLR2, TLR4, and TLR9, with the proportional role of the individual receptors varying depending on fungal species, fungal ..
- Toll-like receptor 2 deficiency delays pneumococcal phagocytosis and impairs oxidative killing by granulocytesMaryse Letiembre
Division of Infectious Diseases, Department of Research, University Hospital, Hebelstrasse 20, CH 4031 Basel, Switzerland
Infect Immun 73:8397-401. 2005..and killing of Streptococcus pneumoniae was compared in blood-derived wild-type (WT) and Toll-like receptor 2 (TLR2)-deficient (TLR2-/-) polymorphonuclear leukocytes (PMN)...
- Toll-like receptor 2 controls expansion and function of regulatory T cellsRoger P M Sutmuller
Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
J Clin Invest 116:485-94. 2006..We have recently shown the CD4CD25 Treg subset in TLR2 mice to be significantly reduced in number compared with WT littermate control mice, indicating a link between ..
- Mannose-binding lectin enhances Toll-like receptors 2 and 6 signaling from the phagosomeW K Eddie Ip
Laboratory of Developmental Immunology, Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
J Exp Med 205:169-81. 2008..Furthermore, we demonstrate that this cooperation occurs within the phagosome, emphasizing the importance of engulfment in providing the appropriate cellular environment to facilitate the synergy between these defense pathways...
- Role of Toll-like receptor 4 in induction of cell-mediated immunity and resistance to Brucella abortus infection in miceMarco A Campos
Department of Biochemistry and Immunology, Biological Sciences Institute, Federal University of Minas Gerais, Belo Horizonte, Brazil
Infect Immun 72:176-86. 2004..CHO reporter cell lines transfected with CD14 and TLRs showed that B. abortus triggers both TLR2 and TLR4...
- TLR2 mediates neuroinflammation and neuronal damageOlaf Hoffmann
Department of Neurology, Center for Anatomy, Charite Universitatsmedizin Berlin, Germany
J Immunol 178:6476-81. 2007..In the case of Gram-positive bacteria, binding of bacterial lipopeptides to TLR2 is currently regarded as an important mechanism...
- Cutting edge: Immune stimulation by neisserial porins is toll-like receptor 2 and MyD88 dependentPaola Massari
Department of Medicine, Division of Infectious Diseases, Boston University School of Medicine, Boston, MA 02118, USA
J Immunol 168:1533-7. 2002..on MyD88 and Toll-like receptor (TLR)2 expression, as demonstrated by a lack of a response by B cells from MyD88 or TLR2 knockout mice to the porins...
- MyD88 mediates neutrophil recruitment initiated by IL-1R but not TLR2 activation in immunity against Staphylococcus aureusLloyd S Miller
Division of Dermatology, David Geffen School of Medicine at UCLA, 52 121 CHS, 10833 Le Conte Avenue, Los Angeles, California 90095, USA
Immunity 24:79-91. 2006MyD88 is an important signaling adaptor for both TLR and IL-1R family members. Here, we evaluated the role of TLR2/MyD88 and IL-1R/MyD88 signaling in host defense against S...
- Regulation of chemokine receptor by Toll-like receptor 2 is critical to neutrophil migration and resistance to polymicrobial sepsisJose C Alves-Filho
Department of Pharmacology, School of Medicine of Ribeirao Preto, University of Sao Paulo, 14049 900 Ribeirao Preto, Brazil
Proc Natl Acad Sci U S A 106:4018-23. 2009..Here we identify a key role of Toll-like receptor 2 (TLR2) in the regulation of neutrophil migration and resistance during polymicrobial sepsis...
- Toll-like receptor 2-deficient mice are highly susceptible to Streptococcus pneumoniae meningitis because of reduced bacterial clearing and enhanced inflammationHakim Echchannaoui
Division of Infectious Diseases, Department of Research, University Hospital, Zurich, Switzerland
J Infect Dis 186:798-806. 2002Toll-like receptor-2 (TLR2) mediates host responses to gram-positive bacterial wall components. TLR2 function was investigated in a murine Streptococcus pneumoniae meningitis model in wild-type (wt) and TLR2-deficient (TLR2(-/-)) mice...
- A critical role of toll-like receptor 2 in nerve injury-induced spinal cord glial cell activation and pain hypersensitivityDongHoon Kim
Program in Molecular and Cellular Neuroscience, Dental Research Institute, BK21, and Department of Oral Physiology, School of Dentistry, Seoul National University, Seoul 110 749, Korea
J Biol Chem 282:14975-83. 2007..These data demonstrate that toll-like receptor 2 contributes to the nerve injury-induced spinal cord glial cell activation and subsequent pain hypersensitivity...
- TLR-mediated stimulation of APC: Distinct cytokine responses of B cells and dendritic cellsTom A Barr
Institute of Immunology and Infection Research, School of Biological Science, University of Edinburgh, Edinburgh, UK
Eur J Immunol 37:3040-53. 2007..IL-10 was elicited by T-dependent activation or stimulation through TLR2, 4 or 9. This pattern of cytokine expression contrasts with that elicited from dendritic cells...
- Toll-like receptor 2 mediates CNS injury in focal cerebral ischemiaSeija Lehnardt
Center for Anatomy, Institute of Cell Biology and Neurobiology, Germany
J Neuroimmunol 190:28-33. 2007..We show here that TLR2-deficient mice develop a decreased CNS injury compared to wild type mice in a model of focal cerebral ischemia...
- Porphyromonas gingivalis lipopolysaccharide contains multiple lipid A species that functionally interact with both toll-like receptors 2 and 4Richard P Darveau
Department of Periodontics, University of Washington, Health Sciences Center, Box 357444, Seattle, WA 98195, USA
Infect Immun 72:5041-51. 2004..gingivalis is unusual in that different studies have reported that it can be an agonist for Toll-like receptor 2 (TLR2) as well as an antagonist or agonist for TLR4. In this report it is shown that P...
- TLR2 and MyD88 contribute to Lactobacillus casei extract-induced focal coronary arteritis in a mouse model of Kawasaki diseaseMargalit E Rosenkranz
Pediatric Rheumatology, Hospital for Special Surgery, Weill Medical College of Cornell University, New York, NY, USA
Circulation 112:2966-73. 2005....
- Yellow fever vaccine YF-17D activates multiple dendritic cell subsets via TLR2, 7, 8, and 9 to stimulate polyvalent immunityTroy Querec
Emory Vaccine Center, Emory University, Atlanta, GA 30329, USA
J Exp Med 203:413-24. 2006..control the Th1/Th2 balance; thus, whilst MyD88-deficient mice show a profound impairment of Th1 cytokines, TLR2-deficient mice show greatly enhanced Th1 and Tc1 responses to YF-17D...
- Differential recognition of TLR-dependent microbial ligands in human bronchial epithelial cellsAnja K Mayer
Department of Medical Microbiology and Hygiene, University Heidelberg, Im Neuenheimer Feld 324, Heidelberg, Germany
J Immunol 178:3134-42. 2007..Although it was observed that TLR2 ligands dependent on heterodimeric signaling either with TLR1 or TLR6 were functional, other ligands like ..
- The Triacylated ATP Binding Cluster Transporter Substrate-binding Lipoprotein of Staphylococcus aureus Functions as a Native Ligand for Toll-like Receptor 2Kenji Kurokawa
National Research Laboratory of Defense Proteins, College of Pharmacy, Pusan National University, Busan 609 735, Korea
J Biol Chem 284:8406-11. 2009..in addition to native lipoproteins derived from both Gram-negative bacteria and mycoplasmas, are known to activate TLR2 (Toll-like receptor 2)...
- Murine toll-like receptor 2 activation induces type I interferon responses from endolysosomal compartmentsNicole Dietrich
Molecular Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany
PLoS ONE 5:e10250. 2010..The TLR2 subfamily of TLRs (TLR1, TLR2, TLR6) form heterodimers with each other and are thus able to recognize a broad range ..
- Herpes simplex virus immediate-early ICP0 protein inhibits Toll-like receptor 2-dependent inflammatory responses and NF-kappaB signalingAllison L van Lint
Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
J Virol 84:10802-11. 2010..Our studies have demonstrated that Toll-like receptor 2 (TLR2) activation by HSV results in NF-κB activation with concomitant inflammatory cytokine production and that TLR2 ..
- Streptococcus pneumoniae stimulates a STING- and IFN regulatory factor 3-dependent type I IFN production in macrophages, which regulates RANTES production in macrophages, cocultured alveolar epithelial cells, and mouse lungsUwe Koppe
Department of Internal Medicine Infectious Diseases and Pulmonary Medicine, Charite University Medicine Berlin, 13353 Berlin, Germany
J Immunol 188:811-7. 2012..In conclusion, we identified an immune sensing pathway detecting S. pneumoniae that triggers a type I IFN response and positively regulates RANTES production...
- Toll-like receptor 2 is required for control of pulmonary infection with Francisella tularensisMeenakshi Malik
Center for Immunology and Microbial Disease, Albany Medical College, 47 New Scotland Avenue, MC151, ME205B, Albany, NY 12208 3479, USA
Infect Immun 74:3657-62. 2006Toll-like receptor 2 (TLR2) deficiency enhances murine susceptibility to infection by Francisella tularensis as indicated by accelerated mortality, higher bacterial burden, and greater histopathology...
- Toll-like receptor 2-mediated signaling requirements for Francisella tularensis live vaccine strain infection of murine macrophagesLeah E Cole
Department of Microbiology and Immunology, University of Maryland, Baltimore, 660 West Redwood Street, Room 324, Baltimore, MD 21201, USA
Infect Immun 75:4127-37. 2007..live vaccine strain (LVS) elicited strong, dose-dependent NF-kappaB reporter activity in Toll-like receptor 2 (TLR2)-expressing HEK293T cells and proinflammatory gene expression in primary murine macrophages...
- Role of Toll-like receptors 2 and 4 in pulmonary inflammation and injury induced by pneumolysin in miceMark C Dessing
Center for Infection and Immunity Amsterdam, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
PLoS ONE 4:e7993. 2009..The primary objective of the present study was to determine the role of TLR2 and TLR4 in lung inflammation induced by intrapulmonary delivery of PLN.
- TLR-2-activated B cells suppress Helicobacter-induced preneoplastic gastric immunopathology by inducing T regulatory-1 cellsAyca Sayi
Institute of Molecular Cancer Research, University of Zurich, Zurich 8057, Switzerland
J Immunol 186:878-90. 2011....
- Macrophages exposed continuously to lipopolysaccharide and other agonists that act via toll-like receptors exhibit a sustained and additive activation stateD A Hume
Institute for Molecular Bioscience, University of Queensland, Brisbane, Q4072, Australia
BMC Immunol 2:11. 2001..In this paper we examine whether the signal from Toll-like receptors [TLRs] is sustained for as long as the ligand is present, and whether responses to different TLR agonists are additive...
- Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteinsOsamu Takeuchi
Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Suita, Japan
J Immunol 169:10-4. 2002..b>TLR2 is essential for the signaling of a variety of PAMPs, including bacterial lipoprotein/lipopeptides, peptidoglycan, ..
- Toll-like receptor 4 mediates mitochondrial DNA damage and biogenic responses after heat-inactivated E. coliHagir B Suliman
Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA
FASEB J 19:1531-3. 2005..In wild-type (Wt) mice injected with heat-inactivated E. coli, hepatic TLR4 and TLR2 proteins were up-regulated with TLR-dependent increases in transcript levels for tumor necrosis factor (TNF-alpha), ..
- Rab5 activation by Toll-like receptor 2 is required for Trypanosoma cruzi internalization and replication in macrophagesElena Maganto-Garcia
Centro de Biologia Molecular Severo Ochoa, CSIC UAM, Universidad Autonoma de Madrid, Cantoblanco, 28049 Madrid, Spain
Traffic 9:1299-315. 2008..Moreover, using macrophages from knockout mice, we found that activation of Rab5, fusion of early endosomes and phagocytosis induced by T. cruzi infection involved Toll-like receptor (TLR)2 but were independent of TLR4 receptors...
- Signalling through TLR2/MyD88 induces differentiation of murine bone marrow stem and progenitor cells to functional phagocytes in response to Candida albicansAlberto Yáñez
Departamento de Microbiologia y Ecologia, Universitat de Valencia, Burjassot, Spain
Cell Microbiol 12:114-28. 2010..In this work, we have found that this process is mainly mediated by TLR2, and that expanding cells express myeloid and not lymphoid markers...
- Induction of cross-tolerance by lipopolysaccharide and highly purified lipoteichoic acid via different Toll-like receptors independent of paracrine mediatorsM D Lehner
Biochemical Pharmacology, University of Konstanz, Konstanz, Germany
J Immunol 166:5161-7. 2001..also inhibits responses to the other stimulus ("cross-tolerance"), suggesting that signaling pathways shared by TLR2 and TLR4 are impaired during tolerance...
- Toll-like receptor 2 plays a role in the early inflammatory response to murine pneumococcal pneumonia but does not contribute to antibacterial defenseSylvia Knapp
Laboratory of Experimental Internal Medicine, Department of Pathology, Tropical Medicine and AIDS, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
J Immunol 172:3132-8. 2004Toll-like receptors (TLR) are crucial pattern recognition receptors in innate immunity. The importance of TLR2 in host defense against Gram-positive bacteria has been suggested by the fact that this receptor recognizes major Gram-positive ..
- NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responsesTomohiro Watanabe
Mucosal Immunity Section, Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 10 Room 11N238, 10 Center Drive, Bethesda, Maryland 20892, USA
Nat Immunol 5:800-8. 2004..Thus, CARD15 mutations may lead to disease by causing excessive T(H)1 responses...
- Tamm-Horsfall glycoprotein links innate immune cell activation with adaptive immunity via a Toll-like receptor-4-dependent mechanismMarcus D Saemann
Department of Internal Medicine III, Division of Nephrology and Dialysis, Medical University Vienna, Vienna, Austria
J Clin Invest 115:468-75. 2005..marrow-derived macrophages from TLR4- and MyD88-deficient mice were nonresponsive to THP in contrast to those from TLR2- and TLR9-deficient mice. In vivo THP-driven TNF-alpha production was evident in WT but not in Tlr4-/- mice...
- TLRs regulate the gatekeeping functions of the intestinal follicle-associated epitheliumSophie Chabot
Department of Pediatrics, Harvard Medical School, GI Cell Biology Laboratory, Children s Hospital Boston and Harvard Digestive Diseases Center, Boston, MA 02115, USA
J Immunol 176:4275-83. 2006..We show that TLR2 is expressed in both FAE and villus epithelium, but TLR2 activation by peptidoglycan or Pam(3)Cys injected into the ..
- TLR2 engagement on CD8 T cells lowers the threshold for optimal antigen-induced T cell activationAnne Cottalorda
Laboratory of Homéostasie Lymphocytaire, INSERM, U503, IFR Biosciences Lyon Gerland, Universite Claude Bernard Lyon I, Lyon, France
Eur J Immunol 36:1684-93. 2006..Here, we report that murine T cells express TLR1, TLR2, TLR6, TLR7 and TLR9 mRNA...
- A critical role for direct TLR2-MyD88 signaling in CD8 T-cell clonal expansion and memory formation following vaccinia viral infectionMichael Quigley
Department of Medicine, Duke University Medical Center, Durham, NC, USA
Blood 113:2256-64. 2009..In this study, we showed that direct TLR2-myeloid differentiating factor 88 (MyD88) signaling in CD8 T cells was also required for their efficient clonal ..
- Exacerbation of murine ileitis by Toll-like receptor 4 mediated sensing of lipopolysaccharide from commensal Escherichia coliM M Heimesaat
Institut für Mikrobiologie und Hygiene, Charite, Universitatsmedizin Berlin, Campus Charite Mitte, Dorotheenstr 96, D 10117 Berlin, Germany
Gut 56:941-8. 2007..In the course of inflammatory bowel diseases (IBD) and acute murine ileitis following peroral Toxoplasma gondii infection, commensal Escherichia coli accumulate at inflamed mucosal sites and aggravate small intestinal immunopathology...
- TLR2 - promiscuous or specific? A critical re-evaluation of a receptor expressing apparent broad specificityUlrich Zahringer
Division of Immunochemistry, Research Center Borstel, Leibniz Center for Medicine and Biosciences, Parkallee 1 40, 23845 Borstel, Germany
Immunobiology 213:205-24. 2008Of all pattern recognition receptors (PRR) in innate immunity, Toll-like receptor 2 (TLR2) recognizes the structurally broadest range of different bacterial compounds known as pathogen-associated molecular patterns (PAMPs)...
- Toll-like receptor 2 controls the gamma interferon response to Francisella tularensis by mouse liver lymphocytesKee Jong Hong
Department of Microbiology, Molecular Genetics and Immunology, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160, USA
Infect Immun 75:5338-45. 2007..tularensis challenge, only DC secreted large quantities of IL-12p70. DC from both IL-12p35-deficient and TLR2-deficient mice failed to produce IL-12p70 and did not costimulate liver lymphocytes for IFN-gamma production in ..
- Lipoproteins in Staphylococcus aureus mediate inflammation by TLR2 and iron-dependent growth in vivoMathias Schmaler
Department of Biomedicine, Division Infection Biology, University Hospital Basel, Basel, Switzerland
J Immunol 182:7110-8. 2009Lipoproteins (Lpp) are ligands of TLR2 and signal by the adaptor MyD88. As part of the bacterial cell envelope, Lpp are mainly involved in nutrient acquisition for Staphylococcus aureus. The impact of Lpp on TLR2-MyD88 activation for S...
- Toll-like receptor-mediated activation of B cells and macrophages by polysaccharide isolated from cell culture of Acanthopanax senticosusS B Han
Biopotency Evaluation Laboratory, Korea Research Institute of Bioscience and Biotechnology KRIBB, 52 Oundong, Yusong, Taejon 305 333, South Korea
Int Immunopharmacol 3:1301-12. 2003..of ASP on B cells and macrophages were significantly reduced by treating the cells with antibodies to TLR4 and TLR2 prior to ASP, suggesting that both of them are the possible receptors of ASP...
- Dectin-1 and TLRs permit macrophages to distinguish between different Aspergillus fumigatus cellular statesGeoffrey M Gersuk
Fred Hutchinson Cancer Research Center, University of Washington, 1100 Fairview Avenue North, Seattle, WA 98109, USA
J Immunol 176:3717-24. 2006..Dectin-1 binding to germ tubes augments, but is not required for, TLR2-mediated inflammatory cytokine secretion...
- Differential involvement of TLR2 and TLR4 in host survival during pulmonary infection with Chlamydia pneumoniaeNuria Rodriguez
Institute of Medical Microbiology, Immunology and Hygiene, Technical University of Munich, Munich, Germany
Eur J Immunol 36:1145-55. 2006The relevance of TLR2 and TLR4 for recognizing Chlamydia pneumoniae in vivo during pulmonary infection and to survive the infection was explored. We found that early immune responses triggered by C...
- Trif is not required for immune complex glomerulonephritis: dying cells activate mesangial cells via Tlr2/Myd88 rather than Tlr3/TrifJulia Lichtnekert
Medizinische Poliklinik, Klinikum der Universität Innenstadt, Pettenkoferstr 8a, 80336 Munich, Germany
Am J Physiol Renal Physiol 296:F867-74. 2009..Because Tlr2-deficient mice were recently found to have attenuated nephrotoxic serum nephritis (NSN), we hypothesized that ..
- Distinct roles for MyD88 and Toll-like receptor 2 during Leishmania braziliensis infection in miceDiego A Vargas-Inchaustegui
Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas 77555 1070, USA
Infect Immun 77:2948-56. 2009..To address this issue, we generated bone marrow-derived DCs from MyD88(-/-) and TLR2(-/-) mice and examined their responsiveness to parasite infection...
- Recipient Toll-like receptors contribute to chronic graft dysfunction by both MyD88- and TRIF-dependent signalingShijun Wang
Department of Cellular and Molecular Pathology, German Cancer Research Center, D 69120 Heidelberg, Germany
Dis Model Mech 3:92-103. 2010..Potential endogenous renal TLR ligands, specifically for TLR2 and TLR4, have now been detected by a significant upregulation of glucose regulated protein (GRP)-94, fibrinogen, ..
- Preconditioning by toll-like receptor 2 agonist Pam3CSK4 reduces CXCL1-dependent leukocyte recruitment in murine myocardial ischemia/reperfusion injuryJan Mersmann
Clinic of Anesthesiology, Intensive Care Medicine, and Pain Management, JW Goethe University, Frankfurt, Germany
Crit Care Med 38:903-9. 2010..To test whether preconditioning with a toll-like receptor (TLR) 2 agonist protects against myocardial ischemia and reperfusion by interfering with chemokine CXCL1 release from cardiomyocytes...
- TLR2 mediates recognition of live Staphylococcus epidermidis and clearance of bacteremiaTobias Strunk
School of Paediatrics and Child Health, University of Western Australia, Perth, Australia
PLoS ONE 5:e10111. 2010..SE-derived soluble components engage TLR2; but additional signaling pathways have also been implicated, and TLR2 can play complex, at times detrimental, ..
- TLR2 activation inhibits embryonic neural progenitor cell proliferationEitan Okun
Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, Maryland 21224, USA
J Neurochem 114:462-74. 2010..To address the possibility that TLR2 heterodimer activation could affect progenitor cells in the developing brain, we analyzed the expression of TLR2 ..
- Mycobacterial infection in TLR2 and TLR6 knockout miceIsamu Sugawara
Department of Molecular Pathology, The Research Institute of Tuberculosis, Kiyose, Tokyo 204 0022, Japan
Microbiol Immunol 47:327-36. 2003To investigate the role of TLR in the development of murine tuberculosis in vivo, TLR2 and TLR6 knockout (KO) mice were infected with Mycobacterium tuberculosis by placing them in the exposure chamber of an airborne infection apparatus...
- Potent inhibition of macrophage responses to IFN-gamma by live virulent Mycobacterium tuberculosis is independent of mature mycobacterial lipoproteins but dependent on TLR2Niaz Banaiee
Department of Medicine, Division of Infectious Diseases, New York University School of Medicine, New York, NY 10016, USA
J Immunol 176:3019-27. 2006..tuberculosis 19-kDa lipoprotein inhibits induction of selected IFN-gamma-responsive genes through a TLR2-dependent pathway, whereas peptidoglycan inhibits responses to IFN-gamma by a TLR2-independent pathway...
- Mycobacterium tuberculosis 19-kDa lipoprotein inhibits IFN-gamma-induced chromatin remodeling of MHC2TA by TLR2 and MAPK signalingMeghan E Pennini
Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA
J Immunol 176:4323-30. 2006..Mtb 19-kDa lipoprotein did not inhibit histone acetylation in TLR2(-/-) macrophages...
- Limited contribution of Toll-like receptor 2 and 4 to the host response to a fungal infectious pathogen, Cryptococcus neoformansKiwamu Nakamura
Department of Medicine and Therapeutics, Control and Prevention of Infectious Diseases, Faculty of Medicine, University of the Ryukyus, Okinawa, Japan
FEMS Immunol Med Microbiol 47:148-54. 2006..Both TLR2 knockout (KO) and TLR4KO mice produced interleukin-1beta (IL-1beta), IL-6, IL-12p40 and tumor necrosis factor-alpha ..
- Innate immune response to Francisella tularensis is mediated by TLR2 and caspase-1 activationHanfen Li
Department of Molecular Sciences, University of Tennessee Health Science Center, Memphis, TN 38163, USA
J Leukoc Biol 80:766-73. 2006..Using cells derived from TLR2-deficient mice and in vitro transfection assays, we demonstrated that this response was mediated by TLR2 and did ..
- Acylation determines the toll-like receptor (TLR)-dependent positive versus TLR2-, mannose receptor-, and SIGNR1-independent negative regulation of pro-inflammatory cytokines by mycobacterial lipomannanEmilie Doz
Orleans University and CNRS, Molecular Immunology and Embryology, UMR6218, 45071 Orleans, France
J Biol Chem 282:26014-25. 2007..BCG LM was shown both to induce macrophage activation and pro-inflammatory cytokines through Toll-like receptor 2 (TLR2) and to inhibit pro-inflammatory cytokine production by lipopolysaccharide (LPS)-activated macrophages through a ..
- Both TLR2 and TLR4 are required for the effective immune response in Staphylococcus aureus-induced experimental murine brain abscessWerner Stenzel
Department of Neuropathology, University of Cologne, Joseph Stelzmann Strasse 9, D 50931 Köln, Germany
Am J Pathol 172:132-45. 2008..Lipoproteins and lipopolysaccharides are specifically recognized by TLR2 and TLR4, respectively...
- Lipoteichoic acid-induced lung inflammation depends on TLR2 and the concerted action of TLR4 and the platelet-activating factor receptorSylvia Knapp
Center for Experimental and Molecular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
J Immunol 180:3478-84. 2008..In vitro data indicate roles for TLR2, platelet-activating factor receptor (PAFR), CD14, and LPS-binding protein (LBP) in cellular responsiveness to LTA, ..
- Group A streptococcus activates type I interferon production and MyD88-dependent signaling without involvement of TLR2, TLR4, and TLR9Nina Gratz
Max F Perutz Laboratories, Department of Microbiology and Immunobiology, University of Vienna, Vienna, Austria
J Biol Chem 283:19879-87. 2008..the extracellular Gram-positive human pathogen group A streptococcus (GAS; Streptococcus pyogenes) does not require TLR2, a receptor implicated in sensing of Gram-positive bacteria, or TLR4 and TLR9...
- PGLYRP-2 and Nod2 are both required for peptidoglycan-induced arthritis and local inflammationSukumar Saha
Indiana University School of Medicine Northwest, Gary, IN 46408, USA
Cell Host Microbe 5:137-50. 2009..Our results demonstrate that PGRPs, Nod2, and TLR4, representing three different types of pattern-recognition molecules, play interdependent in vivo roles in local inflammation...
- Chitin is a size-dependent regulator of macrophage TNF and IL-10 productionCarla A Da Silva
Section of Pulmonary and Critical Care Medicine, Yale University School of Medicine, New Haven, CT 06519, USA
J Immunol 182:3573-82. 2009..The effects of intermediate-sized chitin were mediated by pathways that involve TLR2, dectin-1, and NF-kappaB...
- Differential roles of TLR2 and TLR4 in acute focal cerebral ischemia/reperfusion injury in miceFang Hua
Department of Surgery, East Tennessee State University, Johnson City, TN 37614, USA
Brain Res 1262:100-8. 2009..This study was to investigate the role of TLR2 and TLR4 in acute focal cerebral I/R injury...
- Discrimination of bacterial lipoproteins by Toll-like receptor 6O Takeuchi
Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Suita, Japan
Int Immunol 13:933-40. 2001Bacterial lipoproteins (BLP) trigger immune responses via Toll-like receptor 2 (TLR2) and their immunostimulatory properties are attributed to the presence of a lipoylated N-terminus...
- Toll-like receptor 2 signaling modulates the functions of CD4+ CD25+ regulatory T cellsHaiying Liu
Division of Immunology, Infection, and Inflammation, University of Glasgow, Glasgow G11 6NT, United Kingdom
Proc Natl Acad Sci U S A 103:7048-53. 2006..Synthetic bacterial lipoprotein (BLP) Pam3Cys-SK4 is a TLR2 agonist that is capable of modulating T cell immune responses...
- Codominance of TLR2-dependent and TLR2-independent modulation of MHC class II in Mycobacterium tuberculosis infection in vivoEleanor Z Kincaid
Division of Infectious Diseases, Department of Medicine, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
J Immunol 179:3187-95. 2007..tuberculosis cell envelope, acting as agonists for TLR2, inhibit IFN-gamma induction of MHC class II. In addition, M...
- Innate immune responses in murine pleural mesothelial cells: Toll-like receptor-2 dependent induction of beta-defensin-2 by staphylococcal peptidoglycanTajamul Hussain
Division of Pulmonary Critical Care and Sleep Medicine, HSC Room M452, College of Medicine, Univ of Florida, Gainesville, Florida 32610, USA
Am J Physiol Lung Cell Mol Physiol 295:L461-70. 2008..Taken together, these data indicate that PMCs may contribute to host innate immune defense upon exposure to gram-positive bacteria or their products within the pleural space by upregulating TLR-2 and mBD-2 expression...
- Phagosomal retention of Francisella tularensis results in TIRAP/Mal-independent TLR2 signalingLeah E Cole
Department of Microbiology and Immunology, University of Maryland, Baltimore, Baltimore, MD 21201, USA
J Leukoc Biol 87:275-81. 2010b>TLR2 plays a central role in the activation of innate immunity in response to Ft, the causative agent of tularemia...
- Chlamydia pneumoniae stimulates IFN-gamma synthesis through MyD88-dependent, TLR2- and TLR4-independent induction of IL-18 releaseMihai G Netea
Department of Medicine, University Medical Center Nijmegen, The Netherlands
J Immunol 173:1477-82. 2004..pneumoniae was mediated through TLR2-dependent pathways. In contrast, C...
- Enhancement of macrophage stimulation by lipoteichoic acid and the costimulant hemoglobin is dependent on Toll-like receptors 2 and 4Kathleen H Cox
Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, 800 Madison Avenue, Memphis, Tennessee 38163, USA
Infect Immun 75:2638-41. 2007Macrophage stimulation by lipoteichoic acid (LTA) and hemoglobin (Hb) requires Toll-like receptors 2 and 4 (TLR2 and -4). There are two distinct temporal phases of interleukin-6 (IL-6) production...
- Control of Pseudomonas aeruginosa in the lung requires the recognition of either lipopolysaccharide or flagellinReuben Ramphal
Unité de Défense Innée et Inflammation, Institut Pasteur, Paris, France
J Immunol 181:586-92. 2008..We previously demonstrated that TLR2,4-/- mice were not hypersusceptible to infection by a wild-type P. aeruginosa strain...
- Endogenous ligands for TLR2 and TLR4 are not involved in renal injury following ureteric obstructionParamit Chowdhury
Department of Nephrology and Transplantation, King s College London, Guy s Hospital, London, UK
Nephron Exp Nephrol 115:e122-30. 2010..Those described for TLR2 and TLR4 include molecules released following tissue injury including heat shock proteins and matrix proteins...
- Cutting edge: TLR2-deficient and MyD88-deficient mice are highly susceptible to Staphylococcus aureus infectionO Takeuchi
Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan Core Research for Evolutional Science and Technology of Japan Science and Technology Corporation, Osaka, Japan
J Immunol 165:5392-6. 2000..We previously showed that TLR2 recognizes Gram-positive bacterial components whereas TLR4 recognizes LPS, a component of Gram-negative bacteria...
- Leptospiral lipopolysaccharide activates cells through a TLR2-dependent mechanismC Werts
Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
Nat Immunol 2:346-52. 2001..both these leptospiral outer membrane constituents activate macrophages through CD14 and the Toll-like receptor 2 (TLR2)...
- Hemagglutinin protein of wild-type measles virus activates toll-like receptor 2 signalingKaren Bieback
Institute for Virology and Immunobiology, University of Wurzburg, D 97078 Wurzburg, Germany
J Virol 76:8729-36. 2002..We report that wild-type measles virus but not vaccine strains activate cells via both human and murine TLR2, and this is a property of the hemagglutinin (H) protein...
- Yersinia V-antigen exploits toll-like receptor 2 and CD14 for interleukin 10-mediated immunosuppressionAndreas Sing
Max von Pettenkofer Institut fur Hygiene und Medizinische Mikrobiologie, Ludwig Maximilians Universitat Munchen, Pettenkoferstrasse 9a, Germany
J Exp Med 196:1017-24. 2002..Here we report that recombinant LcrV signals in a CD14- and toll-like receptor 2 (TLR2)-dependent fashion leading to immunosuppression by interleukin 10 induction...
- Cooperation between toll-like receptor 2 and 4 in the brain of mice challenged with cell wall components derived from gram-negative and gram-positive bacteriaNathalie Laflamme
Laboratory of Molecular Endocrinology, CHUL Research Center, Quebec, Canada
Eur J Immunol 33:1127-38. 2003In this study we investigated whether induction of toll-like receptor 2 (TLR2) amplifies the effect of a cell wall component derived from gram-positive bacteria, namely peptidoglycan (PGN)...
- Candida albicans phospholipomannan is sensed through toll-like receptorsThierry Jouault
Laboratoire de Mycologie Fondamentale et Appliquée, Inserm EMI0360, Universite de Lille II, Lille, France
J Infect Dis 188:165-72. 2003..Deletion of the TLR2 gene completely abolished the cell response. Surface expression of PLM is a phylogenic trait of C...
- Toll-like receptor 2-deficient mice succumb to Mycobacterium tuberculosis infectionMichael B Drennan
Department of Immunology, Groote Schuur Hospital, University of Cape Town, Cape Town, South Africa
Am J Pathol 164:49-57. 2004..tuberculosis infection. After aerosol infection with either 100 or 500 live mycobacteria, TLR2-deficient mice display reduced bacterial clearance, a defective granulomatous response, and develop chronic ..
- Impaired production of proinflammatory cytokines and host resistance to acute infection with Trypanosoma cruzi in mice lacking functional myeloid differentiation factor 88Marco A Campos
Department of Biochemistry and Immunology, Instituto de Ciencias Biologicas, and School of Pharmacy, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
J Immunol 172:1711-8. 2004..Here, we evaluated the impact of TLR2 and myeloid differentiation factor 88 (MyD88) deficiencies in host resistance to infection with T. cruzi...
- Saturated fatty acid activates but polyunsaturated fatty acid inhibits Toll-like receptor 2 dimerized with Toll-like receptor 6 or 1Joo Y Lee
Western Human Nutrition Research Center, The Agricultural Research Service United States Department of Agriculture, and Department of Nutrition, University of California Davis, Davis, California 95616, USA
J Biol Chem 279:16971-9. 2004Toll-like receptor 4 (TLR4) and TLR2 agonists from bacterial origin require acylated saturated fatty acids in their molecules...
- Expression of functional TLR4 confers proinflammatory responsiveness to Trypanosoma cruzi glycoinositolphospholipids and higher resistance to infection with T. cruziAna Carolina Oliveira
Instituto de Microbiologia Prof Paulo de Goes, Rio de Janeiro, Brazil
J Immunol 173:5688-96. 2004..In contrast, in TLR2 knockout mice, neutrophil chemoattraction did not differ significantly from that seen in wild-type controls...
- Macrophage defense againt M. tuberculosisJennifer Wang; Fiscal Year: 2008..abstract_text> ..
- Role of cockroach proteases in airway inflammationKristen Page; Fiscal Year: 2009..Finally, we will investigate the role of endogenous TNF alpha in the airways using a TNF alpha neutralizing antibody and TNF alpha knockout mice. ..
- Innate immune responses in lymphatic filariasisAMY HISE; Fiscal Year: 2007..abstract_text> ..
- Heat Shock Proteins and Helicobacter Pylori PathogenesisEvelyn Kurt Jones; Fiscal Year: 2006..Specifically, we will use in vitro and in vivo approaches to investigate the role of heat shock proteins in H. pylori infection and pathogenesis and development of tumors. ..
- Forward Genetic Analysis of the Innate Immune Contribution to MCMV ResistanceBruce Beutler; Fiscal Year: 2006..unreadable] [unreadable] [unreadable]..
- KERATINOCYTE GALVANOTAXIS AND WOUND HEALINGRivkah Isseroff; Fiscal Year: 2006..abstract_text> ..
- Immunological Basis for H. Pylori-Related MalignanciesMarygorret Obonyo; Fiscal Year: 2006..Under this award, the candidate will be able to develop this work into a productive project that will gain independent funding. ..
- Mutagenic analysis of LPS responsesBruce Beutler; Fiscal Year: 2006..In the case of mutations that abolish LPS tolerance, we will attempt to determine the net impact on host resistance to infection. ..
- TLR4 as an LPS sendor and susceptibility locusBruce Beutler; Fiscal Year: 2007..The new mutations that are found--and those that have already been found in preliminary efforts--will be isolated by positional cloning. ..
- Cross-Priming Mechanisms Induced by Microbial ProductsSandip Datta; Fiscal Year: 2007....
- P. gingivalis lipid A species modulation of endothelial cell gene activation progRichard Darveau; Fiscal Year: 2007..gingivalis interactions with TLR4 or other novel LPS receptors. Furthermore, the microarray analysis results will be made public by deposition at the European Bioinformatics Institute Array Express database. [unreadable] [unreadable]..
- MECHANISMS OF NOVEL ANTI-INFLAMMATORY ACTIONS OF SLPIAihao Ding; Fiscal Year: 2007..unreadable] [unreadable]..
- FORMATION AND SURVIVAL OF RED BLOOD CELLSErnest Beutler; Fiscal Year: 2001..Should these point mutations fail to alter gene transcription, a search will be made for other potential mutations in linkage disequilibrium with the known -5,-8 and -24 polymorphisms, by sequencing upstream through the promotor. ..
- Hepatitis C Virus, Alcohol and Host DefenseGyongyi Szabo; Fiscal Year: 2007..Based on our preliminary results, we propose that the pattern recognition receptor, toll-like receptor 2 (TLR2), mediates cellular activation by HCV core and NS3 proteins...
- Investigation of Nod2: Implications for UveitisHolly Rosenzweig; Fiscal Year: 2008..Together, these studies will provide valuable new information on how Nod2 is involved in autoimmunity and the pathogeneis of uveitis. ..
- Toll Receptors in AtherosclerosisLinda Curtiss; Fiscal Year: 2008..We discovered that TLR2-mediated inflammation influences disease progression in low density lipoprotein receptor-deficient (LDLr-/-) mice...
- IMMUNOCHEMICAL STRUCTURE/FUNCTION OF APOLIPOPROTEIN A-ILinda Curtiss; Fiscal Year: 2008..We propose that core lipid reduction by triglyceride hydrolysis and remodeling by PLTP and CETP release lipid-poor apoAI from HDL to facilitate efflux from Mphi foam cells within atherosclerotic lesions. ..
- Ethanols role in mediation of monocyte suppressionGyongyi Szabo; Fiscal Year: 2009..Investigation of the modulation of IL-10 and IL-12 by alcohol in dendritic cell function may identify biomarkers of alcohol-induced immune depression and reveal potential targets for therapy. ..
- B1B lymphocytes generate T cell-independent memoryKISHORE ALUGUPALLI; Fiscal Year: 2009..Understanding the basis for the longevity of the Tl protective responses conferred by B1b cells will provide novel approaches to generate effective vaccines against pathogens expressing Tl antigens. ..
- Mycoplasma Superantigen & RA MHC Susceptibility AllelesBARRY COLE; Fiscal Year: 2006..arthritidis in these "humanized" mice and determine strategies to overcome the effect of the superantigen MAM in initiating disease pathogenesis by modification of the cytokine milieu. ..
- GENETIC ANALYSIS OF CHLAMYDIAL VIRULENCECATHERINE O CONNELL; Fiscal Year: 2002..In addition, we anticipate identifying at least one MoPn gene that contributes to the virulence of this strain. ..
- Pharmacology of 4F Cytochrome P450's (Supplement)ROY SOBERMAN; Fiscal Year: 2003..Luciferase reporter constructs, DNase I footprinting, EMSA, and mutagenesis will identify promoter elements determining the expression of CYP4F3 in hematopoetic and liver cells. ..
- Competition Among Bacterial Resiratory PathogensJeffrey Weiser; Fiscal Year: 2004..Future strategies to decrease disease burden by reducing carriage could result from a greater understanding of interactions between species. ..
- ANTITUMOR IMMUNITY INDUCED BY FUSION CELLS VACCINATIONJianlin Gong; Fiscal Year: 2003..3). To assess the effectiveness of fusion cell vaccines in the prevention and treatment of spontaneous breast carcinoma in transgenic mice. ..
- Interaction of HSV-1 LAT Gene & Dendritic Cells FunctionLbachir BenMohamed; Fiscal Year: 2004..a)Determine if LAT modulates cytokine and chemokine secretion by DC and chemokine-receptor expression on DC, all of which are involved in migratory activity of DC. (b)Determine if LAT changes the observed migratory activity of DC. ..
- Studies on Macrophage Resistance to Anthrax Lethal ToxinMolly Hughes; Fiscal Year: 2004..Successful completion of these studies will yield a fundamental understanding of mechanisms of macrophage resistance to LT. ..
- HOST DEFENSE AGAINST INTRACELLULAR INFECTION OF THE LUNGShawn Skerrett; Fiscal Year: 2005..This aim will test the hypothesis that bacterial dot/icm genes direct macrophage uptake of L. pneumophila by a pathway that results in diminished cellular activation in comparison bacteria deficient in these loci. ..
- LBP/CD14 interactions with bacterial componentsRichard Darveau; Fiscal Year: 2005..These studies will provide further insight into how the innate host defense system recognizes and responds to different bacteria, a key component of both oral health and disease. ..
- A Mouse Model of Gaucher DiseaseErnest Beutler; Fiscal Year: 2005..In particular, electron microscopy and light microscopy will be used to attempt to demonstrate the development of Gaucher cells in the chimeric mice. ..
- HOST IMMUNOREGULATION OF ANTILEISHMANIAL CHEMOTHERAPYHenry Murray; Fiscal Year: 2005..And Aim 3: Characterize immunostimulation in AmB's efficacy, and in recrudescent infection following AmB therapy, pinpoint the likely cytokine-driven T cell mechanism which prevents post-treatment relapse. ..
- Mechanisms of Alcohol Mediated Organ and Tissue DamageGyongyi Szabo; Fiscal Year: 2005..3. Increase the involvement of young investigators in the study of alcohol research. 4. Provide an educational forum to participants. ..
- ASM Conf. on Beneficial Microbial Symbionts in AnimalsRichard Darveau; Fiscal Year: 2005..It is an intellectually stimulating subject that attracts pioneering graduate students and post-doctoral fellows who will benefit from participation in a focused and dynamic conference; ..
- Atherosclerosis in Beige(Lyst) MutantLinda Curtiss; Fiscal Year: 2006..The power of comparing LDLr- /-bg with LDLr-/- mice will allow us to focus on those cellular activities that are physiologically relevant and participate in vivo in a very complex and still poorly understood disease process. ..
- Genes that Mediate Tolerance to the Placental AllograftBruce Beutler; Fiscal Year: 2006..Fourth, circumvention of the toleragenic mechanism might be used to prevent normal gestation, leading to termination of pregnancy within a few days following implantation of the blastocyst. ..
- Host Immunoregulation of Response to Antileishmanial ChemotherapyHenry Murray; Fiscal Year: 2007..abstract_text> ..
- Functional role of Angiopoietin-2 in diabetic heartJian xiong Chen; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- Toll-like Receptors and the Innate Immune ResponseTHOMAS HAWN; Fiscal Year: 2003..The aims of this proposal are to examine the effects of TLR2 in MTh and Leishmania major mouse infection models and to characterize TLR-dependent inflammatory signaling ..
- BACTERIAL PHOSPHORYLCHOLINE AND PATHOGENESISJeffrey Weiser; Fiscal Year: 2009..Aim 3 will determine the effects of the immune response to ChoP on colonization, where our findings demonstrate that expression of ChoP is most important to pathogenesis. ..
- TLR5 and Pulmonary Innate ImmunityTHOMAS HAWN; Fiscal Year: 2009..The immunogenetic models derived from these studies will illuminate the molecular basis of why individuals have different susceptibility to flagellated bacterial infections and hopefully culminate in novel insights for future therapies. ..
- Oral Commensal Bacterial Modulation of the Periodontal Innate Host ResponseRICHARD PETERS DARVEAU; Fiscal Year: 2010..n Specific Aim 3 changes in gingival epithelial cell TLR2 and TLR4 expression levels that may alter commensal homeostasis with the host will be determined...
- Identification of E. histolytica virulence factorsMolly Hughes; Fiscal Year: 2004..Successful completion of these studies will yield a fundamental understanding of amebic proteins that interact with the E. histolytica GalNAc lectin and their role in pathogenicity. ..
- MYCOPLASMA SUPERANTIGEN MAM IN DISEASE AND AUTOIMMUNITYHong Hua Mu; Fiscal Year: 2003..Specifically the investigator shall define the role played by SAg-induced cytokines and protection against disease using the MAM vaccines described earlier. ..