Tlr1

Summary

Gene Symbol: Tlr1
Description: toll-like receptor 1
Alias: toll-like receptor 1, TIL, toll/interleukin-1 receptor-like protein
Species: mouse

Top Publications

  1. ncbi Toll-like receptors 1 and 6 are involved in TLR2-mediated macrophage activation by hepatitis C virus core and NS3 proteins
    Serena Chang
    Department of Medicine, University of Massachusetts Medical School, LRB 215, 364 Plantation Street, Worcester, MA 01605 2324, USA
    J Leukoc Biol 82:479-87. 2007
  2. pmc Toll-like receptors 1 and 2 heterodimers alter Borrelia burgdorferi gene expression in mice and ticks
    Erol Fikrig
    Section of Infectious Diseases, Department of Internal Medicine, 2Howard Hughes Medical Institute, and 3Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut
    J Infect Dis 200:1331-40. 2009
  3. pmc The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors
    A Ozinsky
    Department of Immunology, University of Washington, H 574 Health Sciences, Box 357650, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 97:13766-71. 2000
  4. ncbi Cutting edge: functional interactions between toll-like receptor (TLR) 2 and TLR1 or TLR6 in response to phenol-soluble modulin
    A M Hajjar
    Department of Immunology, University of Washington, Seattle, WA 98195, USA
    J Immunol 166:15-9. 2001
  5. pmc A specific role for TLR1 in protective T(H)17 immunity during mucosal infection
    R William DePaolo
    Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    J Exp Med 209:1437-44. 2012
  6. ncbi Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins
    Osamu Takeuchi
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Suita, Japan
    J Immunol 169:10-4. 2002
  7. ncbi Hyporesponsiveness to vaccination with Borrelia burgdorferi OspA in humans and in TLR1- and TLR2-deficient mice
    Lena Alexopoulou
    Section of Immunobiology and The Howard Hughes Medical Institute, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA
    Nat Med 8:878-84. 2002
  8. pmc Toll-like receptor 2 is required for inflammatory responses to Francisella tularensis LVS
    Jannet Katz
    Department of Pediatric Dentistry, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Infect Immun 74:2809-16. 2006
  9. ncbi TLR1- and TLR6-independent recognition of bacterial lipopeptides
    Ute Buwitt-Beckmann
    Department of Immunology and Cell Biology, Research Center Borstel, 23845 Borstel, Germany
    J Biol Chem 281:9049-57. 2006
  10. ncbi Role of TLR1 and TLR6 in the host defense against disseminated candidiasis
    Mihai G Netea
    Department of Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    FEMS Immunol Med Microbiol 52:118-23. 2008

Research Grants

  1. Atherosclerosis in Beige(Lyst) Mutant
    Linda Curtiss; Fiscal Year: 2006
  2. Toll Receptors in Atherosclerosis
    Linda Curtiss; Fiscal Year: 2008
  3. IMMUNOCHEMICAL STRUCTURE/FUNCTION OF APOLIPOPROTEIN A-I
    Linda Curtiss; Fiscal Year: 2008
  4. Genes that Mediate Tolerance to the Placental Allograft
    Bruce Beutler; Fiscal Year: 2006
  5. Forward Genetic Analysis of the Innate Immune Contribution to MCMV Resistance
    Bruce Beutler; Fiscal Year: 2006
  6. Mutagenic analysis of LPS responses
    Bruce Beutler; Fiscal Year: 2006
  7. TLR4 as an LPS sendor and susceptibility locus
    Bruce Beutler; Fiscal Year: 2007
  8. B1B lymphocytes generate T cell-independent memory
    KISHORE ALUGUPALLI; Fiscal Year: 2009

Scientific Experts

  • Jannet Katz
  • R William DePaolo
  • Linda Curtiss
  • M G Netea
  • BRUCE A BEUTLER
  • KISHORE ALUGUPALLI
  • De Yang
  • S Ribes
  • Michael B Drennan
  • Barbara Albiger
  • Shizuo Akira
  • Chun Jen Chen
  • Koichiro Takahashi
  • Takaaki Doi
  • Douglas Golenbock
  • Mikael M Martino
  • Elisha de Valle
  • Surya Prakash Pandey
  • Osamu Takeuchi
  • Erol Fikrig
  • Egest J Pone
  • Yun Kyoung Ryu
  • Yuji Motoi
  • Alfred C Aplin
  • Ali M Saeed
  • Fumito Hanihara-Tatsuzawa
  • Dalia E Gaddis
  • Thimoteus Speer
  • Y Sugiura
  • Hejiang Zhou
  • David Kaul
  • Ivana Rubino
  • Mattias Enoksson
  • Marije Oosting
  • Socorro Miranda-Hernandez
  • A Phillip West
  • Yi Zhang
  • Linnea Stridh
  • Kensuke Miyake
  • Takuma Shibata
  • Edward A Medina
  • Eitan Okun
  • Tracie A Seimon
  • Chih Hsiang Leng
  • Ian R Morris
  • Michael T Berton
  • Sunhwa Kim
  • Allison L Abplanalp
  • Himanshu Kumar
  • Michael G Drage
  • Matthew R Murawski
  • Torsten G Loof
  • Hooman Izadi
  • Dieudonnée Togbe
  • David Vallois
  • Milena Bogunovic
  • Serena Chang
  • Kenneth L Rock
  • George Reed
  • Yaya Wang
  • A M Hajjar
  • Ute Buwitt-Beckmann
  • A Ozinsky
  • Sabine Tötemeyer
  • Dianhua Jiang
  • O Takeuchi
  • Juan Anguita
  • Joo Y Lee
  • Yoshiko Mizukawa
  • Yoshimi Yamazaki
  • Tetsuo Shiohara
  • Ruslan Medzhitov
  • Yurie Shimoda
  • Ajithkumar Vasanthakumar
  • Ashish Banerjee
  • Simon N Willis
  • Ralph Muller
  • George Grigoriadis
  • Kenta Maruyama
  • Mark A Febbraio
  • Kirsten A Fairfax
  • Jasper K S Cornish
  • Fabienne Mackay
  • Gisela A Kuhn
  • Raffi Gugasyan
  • Lorraine A O'Reilly
  • Axel Kallies
  • Marc Pellegrini
  • Takashi Satoh
  • Evelyn Tsantikos

Detail Information

Publications64

  1. ncbi Toll-like receptors 1 and 6 are involved in TLR2-mediated macrophage activation by hepatitis C virus core and NS3 proteins
    Serena Chang
    Department of Medicine, University of Massachusetts Medical School, LRB 215, 364 Plantation Street, Worcester, MA 01605 2324, USA
    J Leukoc Biol 82:479-87. 2007
    ..TLR2 activation requires homo- or heterodimerization with TLR1 or TLR6...
  2. pmc Toll-like receptors 1 and 2 heterodimers alter Borrelia burgdorferi gene expression in mice and ticks
    Erol Fikrig
    Section of Infectious Diseases, Department of Internal Medicine, 2Howard Hughes Medical Institute, and 3Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut
    J Infect Dis 200:1331-40. 2009
    ..burgdorferi gene expression in murine skin showed that several genes were altered in TLR1/2-deficient animals compared with wild-type mice. For example, expression of bbe21 (a gene involved in B...
  3. pmc The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors
    A Ozinsky
    Department of Immunology, University of Washington, H 574 Health Sciences, Box 357650, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 97:13766-71. 2000
    ..We show that the cytoplasmic domain of TLR2 can form functional pairs with TLR6 or TLR1, and this interaction leads to cytokine induction...
  4. ncbi Cutting edge: functional interactions between toll-like receptor (TLR) 2 and TLR1 or TLR6 in response to phenol-soluble modulin
    A M Hajjar
    Department of Immunology, University of Washington, Seattle, WA 98195, USA
    J Immunol 166:15-9. 2001
    ..The TLR2-mediated response to this modulin was enhanced by TLR6 but inhibited by TLR1, indicating a functional interaction between these receptors...
  5. pmc A specific role for TLR1 in protective T(H)17 immunity during mucosal infection
    R William DePaolo
    Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    J Exp Med 209:1437-44. 2012
    ..Furthermore, induction of T(H)17 immunity during oral infection is dependent on TLR1 and results from the combinatorial effect of TLR2/TLR1-induced IL-6 and IL-23 and the presence of TGF-β in the ..
  6. ncbi Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins
    Osamu Takeuchi
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Suita, Japan
    J Immunol 169:10-4. 2002
    ..TLR6 associates with TLR2 and recognizes diacylated mycoplasmal lipopeptide along with TLR2. We report here that TLR1 associates with TLR2 and recognizes the native mycobacterial 19-kDa lipoprotein along with TLR2...
  7. ncbi Hyporesponsiveness to vaccination with Borrelia burgdorferi OspA in humans and in TLR1- and TLR2-deficient mice
    Lena Alexopoulou
    Section of Immunobiology and The Howard Hughes Medical Institute, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA
    Nat Med 8:878-84. 2002
    ..After OspA immunization, mice genetically deficient in either TLR2 (TLR2(-/-)) or TLR1 (TLR1(-/-)) produced low titers of antibodies against OspA...
  8. pmc Toll-like receptor 2 is required for inflammatory responses to Francisella tularensis LVS
    Jannet Katz
    Department of Pediatric Dentistry, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Infect Immun 74:2809-16. 2006
    ..TLR6, not TLR1, was shown to be involved in mediating the inflammatory response to F...
  9. ncbi TLR1- and TLR6-independent recognition of bacterial lipopeptides
    Ute Buwitt-Beckmann
    Department of Immunology and Cell Biology, Research Center Borstel, 23845 Borstel, Germany
    J Biol Chem 281:9049-57. 2006
    ..Triacylated lipopeptides are assumed to be recognized by TLR2/TLR1-, whereas diacylated lipopeptides use TLR2/TLR6 heteromers for signaling...
  10. ncbi Role of TLR1 and TLR6 in the host defense against disseminated candidiasis
    Mihai G Netea
    Department of Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    FEMS Immunol Med Microbiol 52:118-23. 2008
    Toll-like receptor-1 (TLR1) and TLR6 are receptors of the TLR family that form heterodimers with TLR2. The role of TLR1 and TLR6 for the recognition of the fungal pathogen Candida albicans was investigated...
  11. pmc The oxidative stress product carboxyethylpyrrole potentiates TLR2/TLR1 inflammatory signaling in macrophages
    Ali M Saeed
    Sheila and David Fuente Program in Cancer Biology, University of Miami Miller School of Medicine, Miami, Florida, United States of America
    PLoS ONE 9:e106421. 2014
    ..Moreover, CEP selectively augments TLR2/TLR1-signaling instead of TLR2/TLR6-signaling...
  12. doi Importance of Water Content of the Stratum Corneum in Mouse Models for Contact Hypersensitivity
    Takaaki Doi
    Department of Dermatology, Kyorin University School of Medicine, Mitaka, Tokyo, Japan
    J Invest Dermatol 137:151-158. 2017
    ..These findings indicate that increased levels of water in the stratum corneum serve to ameliorate the CHS beyond the genetic effects...
  13. pmc Control of Toll-like receptor-mediated T cell-independent type 1 antibody responses by the inducible nuclear protein IκB-ζ
    Fumito Hanihara-Tatsuzawa
    From the Laboratory of Cell Recognition and Response, Department of Developmental Biology and Neurosciences, Graduate School of Life Sciences, Tohoku University, Sendai, Miyagi 980 8578
    J Biol Chem 289:30925-36. 2014
    ..These results indicate that IκB-ζ regulates TLR-mediated CSR by inducing AID. Moreover, IκB-ζ defines differences in the transcriptional regulation of different antibody responses. ..
  14. doi Lipopeptides are signaled by Toll-like receptor 1, 2 and 6 in endolysosomes
    Yuji Motoi
    Division of Innate Immunity, The Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Minatoku, Tokyo 108 8639, Japan
    Int Immunol 26:563-73. 2014
    ..TLR-dependent responses are greatly influenced by the site of pathogen sensing. TLR heterodimers TLR1/TLR2 and TLR2/TLR6 recognize tri- or diacylated microbial lipopeptides, respectively...
  15. pmc c-Jun N-terminal kinase 1 is required for Toll-like receptor 1 gene expression in macrophages
    Hooman Izadi
    Department of Veterinary and Animal Sciences, University of Massachusetts Amherst, MA 01003, USA
    Infect Immun 75:5027-34. 2007
    ..We demonstrate a mechanism of control of murine macrophage responses mediated by TLR1/2 heterodimers through c-Jun N-terminal kinase 1 (JNK1) activity...
  16. doi Regulation of angiogenesis, mural cell recruitment and adventitial macrophage behavior by Toll-like receptors
    Alfred C Aplin
    Department of Pathology, University of Washington, Seattle, WA, USA
    Angiogenesis 17:147-61. 2014
    ..b>TLR1, 3, and 6 are transiently upregulated at 24 h whereas TLR2, 4, and 8 expression peaks at 24 h but remains ..
  17. pmc TLR1-induced chemokine production is critical for mucosal immunity against Yersinia enterocolitica
    Y Sugiura
    Department of Biomedical Sciences, Midwestern University, Downers Grove, Illinois, USA
    Mucosal Immunol 6:1101-9. 2013
    ..Here we demonstrate that activation of Toll-like receptor 1 (TLR1) in the epithelium leads to the upregulation of the chemokine CCL20 during oral infection with Yersinia ..
  18. pmc Atherosclerosis induced by endogenous and exogenous toll-like receptor (TLR)1 or TLR6 agonists
    Linda K Curtiss
    Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA, USA
    J Lipid Res 53:2126-32. 2012
    ..TLR2 forms heterodimers with TLR1 or TLR6 to enable inflammatory responses in the presence of distinct ligands...
  19. doi Species-specific recognition of Aspergillus fumigatus by Toll-like receptor 1 and Toll-like receptor 6
    Ivana Rubino
    Department of Medicine, University of Lausanne, Switzerland
    J Infect Dis 205:944-54. 2012
    ..Innate immune detection of A. fumigatus involves Toll-like receptor (TLR) 4 and TLR2, which forms a heterodimer with either TLR1 or TLR6. The role of those coreceptors in Aspergillus sensing is unknown.
  20. doi γ-Irradiated cancer cells promote tumor growth by activation of Toll-like receptor 1-mediated inducible nitric oxide synthase in macrophages
    Yun Kyoung Ryu
    Department of Bioscience and Biotechnology, Sejong University, Seoul, Korea and Molecular Imaging Research Center, Korea Institute of Radiological and Medical Science, Seoul, Korea
    J Leukoc Biol 97:711-21. 2015
    ..Although iNOS activity was reduced by inhibiting TLR1 expression with TLR1-siRNA, it was enhanced by TLR1 overexpression...
  21. ncbi Structural basis for signal transduction by the Toll/interleukin-1 receptor domains
    Y Xu
    Department of Biological Sciences, Columbia University, New York, New York 10027, USA
    Nature 408:111-5. 2000
    ..Here we report the crystal structures of the TIR domains of human TLR1 and TLR2 and of the Pro681His mutant of TLR2...
  22. pmc NFκB1 is essential to prevent the development of multiorgan autoimmunity by limiting IL-6 production in follicular B cells
    Elisha de Valle
    Burnet Institute, Melbourne, VIC 3004, Australia Immunology, Central Clinical School, Monash University, Melbourne, VIC 3004, Australia
    J Exp Med 213:621-41. 2016
    ..Collectively, our findings identify a previously unrecognized role for NFκB1 in preventing multiorgan autoimmunity through its negative regulation of Il-6 gene expression in Fo B cells...
  23. ncbi Saturated fatty acid activates but polyunsaturated fatty acid inhibits Toll-like receptor 2 dimerized with Toll-like receptor 6 or 1
    Joo Y Lee
    Western Human Nutrition Research Center, The Agricultural Research Service United States Department of Agriculture, and Department of Nutrition, University of California Davis, Davis, California 95616, USA
    J Biol Chem 279:16971-9. 2004
    ..A saturated fatty acid, lauric acid, induced NFkappaB activation when TLR2 was co-transfected with TLR1 or TLR6 in 293T cells, but not when TLR1, 2, 3, 5, 6, or 9 was transfected individually...
  24. pmc Sublethal infection of C57BL/6 mice with Salmonella enterica Serovar Typhimurium leads to an increase in levels of Toll-like receptor 1 (TLR1), TLR2, and TLR9 mRNA as well as a decrease in levels of TLR6 mRNA in infected organs
    Sabine Tötemeyer
    Centre for Veterinary Science, Department of Clinical Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 0ES, United Kingdom
    Infect Immun 73:1873-8. 2005
    ..enterica serovar Typhimurium infection. During infection, the Toll-lie receptor 1 (TLR1), TLR2, and TLR9 mRNA levels increased, while TLR6 mRNA expression decreased.
  25. pmc Inhibition of IL-1R1/MyD88 signalling promotes mesenchymal stem cell-driven tissue regeneration
    Mikael M Martino
    WPI Immunology Frontier Research Center, Osaka University, 3 1 Yamada oka, Suita, Osaka 565 0871, Japan
    Nat Commun 7:11051. 2016
    ..Using this strategy, we considerably improve MSC-based bone regeneration in the mouse, demonstrating that this approach may be useful in regenerative medicine applications. ..
  26. ncbi The induction of a type 1 immune response following a Trypanosoma brucei infection is MyD88 dependent
    Michael B Drennan
    Immunology of Infectious Disease Medical Research Council University of Cape Town Unit, Institute of Infectious Disease and Molecular Medicine, Health Science Faculty, University of Cape Town, Cape Town, South Africa
    J Immunol 175:2501-9. 2005
    ..brucei infections. These results implicate the mammalian TLR family and MyD88 signaling in the innate immune recognition of T. brucei...
  27. doi TLR9-deficiency reduces TLR1, TLR2 and TLR3 expressions in Leishmania major-infected macrophages
    Surya Prakash Pandey
    National Centre for Cell Science, Ganeshkhind, Pune 411007, India Electronic address
    Exp Parasitol 154:82-6. 2015
    The parasite Leishmania major counteractively modulates TLR2 and TLR9 expression and their functions. Although TLR1, TLR3, TLR4, and TLR7 are also implicated in Leishmania infection, whether their expression was altered in TLR2 or TLR9 ..
  28. ncbi Association of beta-arrestin and TRAF6 negatively regulates Toll-like receptor-interleukin 1 receptor signaling
    Yaya Wang
    Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, People s Republic of China
    Nat Immunol 7:139-47. 2006
    ..Thus, beta-arrestins are essential negative regulators of innate immune activation via TLR-IL-1R signaling...
  29. pmc MyD88-dependent IL-1 receptor signaling is essential for gouty inflammation stimulated by monosodium urate crystals
    Chun Jen Chen
    Department of Pathology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Clin Invest 116:2262-71. 2006
    ..The MyD88-dependent TLR1, -2, -4, -6, -7, -9, and -11 and IL-18 receptor (IL-18R) are not essential for MSU-induced inflammation...
  30. pmc B cell TLR1/2, TLR4, TLR7 and TLR9 interact in induction of class switch DNA recombination: modulation by BCR and CD40, and relevance to T-independent antibody responses
    Egest J Pone
    Institute for Immunology, University of California, Irvine, CA, USA
    Autoimmunity 48:1-12. 2015
    ..In the presence of BCR crosslinking, LPS synergized with a TLR1/2 ligand (Pam3CSK4) in CSR induction, but much less efficiently with a TLR7 (R-848) or TLR9 (CpG) ligand...
  31. doi Abnormal high-density lipoprotein induces endothelial dysfunction via activation of Toll-like receptor-2
    Thimoteus Speer
    Cardiovascular Center, Cardiology, University Hospital Zurich and Cardiovascular Research, Institute of Physiology, University of Zurich, Zurich, Switzerland
    Immunity 38:754-68. 2013
    ....
  32. pmc Role of TLR2-dependent IL-10 production in the inhibition of the initial IFN-γ T cell response to Porphyromonas gingivalis
    Dalia E Gaddis
    University of Alabama at Birmingham, 845 19th Street South, Birmingham, AL 35294 2170, USA
    J Leukoc Biol 93:21-31. 2013
    ..g. exposure and suggest multiple inhibitory mechanisms potentially used by P.g. to evade the host's immune response, thus allowing its persistence in the host...
  33. doi The interactions between pristine graphene and macrophages and the production of cytokines/chemokines via TLR- and NF-κB-related signaling pathways
    Hejiang Zhou
    National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China
    Biomaterials 33:6933-42. 2012
    ..Further research is needed to systematically assess the biological responses of graphene, both to improve its safety and to contribute to the design of new biological applications...
  34. pmc Expression of Toll-like receptors in the developing brain
    David Kaul
    Department of Neurology, Charite Universitaetsmedizin Berlin, Berlin, Germany
    PLoS ONE 7:e37767. 2012
    ..use of real-time PCR, in situ hybridization, and immunohistochemistry we systematically examined the expression of TLR1-9 and the intracellular adaptor molecules MyD88 and TRIF during development of the mouse brain...
  35. pmc TLR2 and its co-receptors determine responses of macrophages and dendritic cells to lipoproteins of Mycobacterium tuberculosis
    Michael G Drage
    Department of Pathology, Case Western Reserve University School of Medicine University Hospitals Case Medical Center, Cleveland, OH 44106, USA
    Cell Immunol 258:29-37. 2009
    ..We studied Mtb lipoprotein-induced responses in TLR2(-/-), TLR1(-/-), TLR6(-/-), CD14(-/-) and CD36(-/-) macrophages...
  36. pmc TLR1/TLR2 heterodimers play an important role in the recognition of Borrelia spirochetes
    Marije Oosting
    Department of Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    PLoS ONE 6:e25998. 2011
    ..While TLR2 is the main recognition receptor for Borrelia spp., little is known about the role of TLR1 and TLR6, which both can form functionally active heterodimers with TLR2...
  37. doi Role for MyD88, TLR2 and TLR9 but not TLR1, TLR4 or TLR6 in experimental autoimmune encephalomyelitis
    Socorro Miranda-Hernandez
    Comparative Genomics Centre, James Cook University, Townsville, Queensland 4811, Australia
    J Immunol 187:791-804. 2011
    ..In this study, we examined the effects of targeted deletions of TLR1, TLR2, TLR4, TLR6, TLR9, and MyD88 on the induction of myelin oligodendrocyte glycoprotein 35-55 (MOG(35-55)) ..
  38. pmc Regulation of toll-like receptor 1 and -2 in neonatal mice brains after hypoxia-ischemia
    Linnea Stridh
    Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Sweden
    J Neuroinflammation 8:45. 2011
    ..Toll-like receptors (TLRs), which are key components of the innate immune system, are believed to play a role in adult cerebral ischemic injury. The expression of TLRs in the neonatal brain and their regulation after HI is unknown...
  39. pmc TLR signalling augments macrophage bactericidal activity through mitochondrial ROS
    A Phillip West
    Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Nature 472:476-80. 2011
    ..Here we demonstrate that engagement of a subset of Toll-like receptors (TLR1, TLR2 and TLR4) results in the recruitment of mitochondria to macrophage phagosomes and augments mROS production...
  40. doi Mast cells as sensors of cell injury through IL-33 recognition
    Mattias Enoksson
    Clinical Immunology and Allergy Unit, Department of Medicine, Karolinska Institute, SE 171 76 Stockholm, Sweden
    J Immunol 186:2523-8. 2011
    ..Our findings identify IL-33 as a key danger signal released by necrotic structural cells capable of activating mast cells, thus providing novel insights concerning the role of mast cells as sensors of cell injury...
  41. pmc Eosinophil-derived neurotoxin acts as an alarmin to activate the TLR2-MyD88 signal pathway in dendritic cells and enhances Th2 immune responses
    De Yang
    Basic Research Program, SAIC Frederick, Inc, MD, USA
    J Exp Med 205:79-90. 2008
    ..EDN activates TLR2 independently of TLR1 or TLR6...
  42. ncbi Host resistance to infection: genetic control of lipopolysaccharide responsiveness by TOLL-like receptor genes
    S T Qureshi
    Department of Medicine, McGill University, Montreal, Quebec, Canada H3G 1Y6
    Trends Genet 15:291-4. 1999
    ..Tlr4 is a member of an ancient gene family that regulates antimicrobial host defense in plants, invertebrates and mammals...
  43. ncbi Novel engagement of CD14 and multiple toll-like receptors by group B streptococci
    P Henneke
    Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    J Immunol 167:7069-76. 2001
    ..In addition to TLR2, TLR6 and CD14 expression were essential for GBS-F responses, whereas TLR1 and TLR4 or MD-2 did not appear to be involved...
  44. ncbi The Toll-like receptors: analysis by forward genetic methods
    Bruce Beutler
    The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, 92037, USA
    Immunogenetics 57:385-92. 2005
    ..These include the development of fever, shock, and tissue injury, but also the activation of innate and adaptive effector mechanisms that lead to the elimination of microbes...
  45. ncbi Regulation of lung injury and repair by Toll-like receptors and hyaluronan
    Dianhua Jiang
    Department of Medicine, Section of Pulmonary and Critical Care Medicine, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06520, USA
    Nat Med 11:1173-9. 2005
    ..Hyaluronan-TLR2 and hyaluronan-TLR4 interactions provide signals that initiate inflammatory responses, maintain epithelial cell integrity and promote recovery from acute lung injury...
  46. ncbi Toll-like receptor 9 acts at an early stage in host defence against pneumococcal infection
    Barbara Albiger
    Swedish Institute for Infectious Disease Control and Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Nobels Väg 18, SE 171 82 Solna, Sweden
    Cell Microbiol 9:633-44. 2007
    ..Here, we show that mice deficient in TLR9 but not in TLR1, TLR2, TLR4 and TLR6 or IL-1R/IL-18R are more susceptible to a respiratory tract bacterial infection caused by ..
  47. ncbi MyD88- and Bruton's tyrosine kinase-mediated signals are essential for T cell-independent pathogen-specific IgM responses
    Kishore R Alugupalli
    Department of Microbiology and Immunology and Kimmel Cancer Center, Thomas Jefferson University, 233 South 10th Street, Philadelphia, PA 19107, USA
    J Immunol 178:3740-9. 2007
    ..B. hermsii contains putative ligands for TLRs, and we found that mice deficient in TLR1, TLR2, or the TLR adaptor MyD88 generated anti-B...
  48. pmc Enteroendocrine cells express functional Toll-like receptors
    Milena Bogunovic
    Div of Gastroenterology and Hepatology, Univ of North Carolina School of Medicine, 103 Mason Farm Rd, Campus Box 7032, 7341C MBRB, Chapel Hill, NC 27599 7032, USA
    Am J Physiol Gastrointest Liver Physiol 292:G1770-83. 2007
    ..b>TLR1, TLR2, and TLR4 are coexpressed on a subpopulation of human and murine IECs that reside predominantly in the ..
  49. pmc Murine cerebral malaria development is independent of toll-like receptor signaling
    Dieudonnée Togbe
    Molecular Immunology and Embryology, Centre National de la Recherche Scientifique, and University of Orleans, Transgenose Institute, Orleans, France
    Am J Pathol 170:1640-8. 2007
    ..To exclude the role of other members of the TLR family in PbA recognition, we infected mice deficient for single TLR1, -2, -3, -4, -6, -7, or -9 and their adapter proteins MyD88, TIRAP, and TRIF...
  50. ncbi Identification of a key pathway required for the sterile inflammatory response triggered by dying cells
    Chun Jen Chen
    Department of Pathology, University of Massachusetts Medical School, 55 Lake Avenue North, Room S2 109, Worcester, Massachusetts 01655, USA
    Nat Med 13:851-6. 2007
    ..reduction in mice doubly deficient in Toll-like receptor 2 (Tlr2) and Tlr4 and normal responses in mice lacking Tlr1, Tlr3, Tlr6, Tlr7, Tlr9, Tlr11 or the interleukin-18 receptor (IL-18R)...
  51. ncbi The type 1 diabetes locus Idd6 controls TLR1 expression
    David Vallois
    Unité de Génétique Moléculaire Murine Centre National de la Recherche Scientifique, Unité de Recherche Associée 2578, Institut Pasteur, Paris, France
    J Immunol 179:3896-903. 2007
    ..C3H-congenic mouse strains exhibit a constitutive and specific down-regulation of Toll-like receptor 1 (Tlr1) gene expression compared with diabetes prone NOD mice...
  52. pmc A protein associated with Toll-like receptor (TLR) 4 (PRAT4A) is required for TLR-dependent immune responses
    Koichiro Takahashi
    Division of Infectious Genetics, The Institute of Medical Science, The University of Tokyo, Minato ku, Tokyo 108 8639, Japan
    J Exp Med 204:2963-76. 2007
    ..PRAT4A resides in the endoplasmic reticulum, and PRAT4A knockdown inhibited trafficking of TLR1 and TLR4 to the cell surface and ligand-induced trafficking of TLR9 to lysosomes...
  53. doi TLR1/TLR2 agonist induces tumor regression by reciprocal modulation of effector and regulatory T cells
    Yi Zhang
    Department of Immunology, Shanghai Medical College, Key Laboratory of Molecular Medicine of Ministry of Education, Fudan University, Shanghai 200032, People s Republic of China
    J Immunol 186:1963-9. 2011
    ..In this study, we report a general immunotherapeutic activity of a synthetic bacterial lipoprotein (BLP), a TLR1/TLR2 agonist, on established lung carcinoma, leukemia, and melanoma in mice...
  54. pmc Immune recognition of Streptococcus pyogenes by dendritic cells
    Torsten G Loof
    Infection Immunology Research Group, Department of Microbial Pathogenesis, Helmholtz Center for Infection Research, Inhoffenstrasse 7, 38124 Braunschweig, Germany
    Infect Immun 76:2785-92. 2008
    ..in signaling through each of the TLRs reported as potential receptors for gram-positive cell components, such as TLR1, TLR2, TLR4, TLR9, and TLR2/6, were not impaired in the secretion of proinflammatory cytokines and the up-..
  55. pmc Toll-like receptor prestimulation increases phagocytosis of Escherichia coli DH5alpha and Escherichia coli K1 strains by murine microglial cells
    Sandra Ribes
    Department of Neurology, University of Gottingen, Robert Koch Str 40, D 37075 Gottingen, Germany
    Infect Immun 77:557-64. 2009
    ..coli. Here, murine microglial cultures were stimulated with the TLR agonists Pam(3)CSK(4) (TLR1/TLR2), lipopolysaccharide (TLR4), and CpG oligodeoxynucleotide (TLR9) for 24 h...
  56. pmc Respiratory syncytial virus activates innate immunity through Toll-like receptor 2
    Matthew R Murawski
    Department of Medicine, University of Massachusetts Medical Center, 364 Plantation Street, Lazare Research Building, Worcester, Massachusetts 01605, USA
    J Virol 83:1492-500. 2009
    ..Additionally, TLR2 interactions with RSV promoted neutrophil migration and dendritic cell activation within the lung. Collectively, these studies indicate that TLR2 is involved in RSV recognition and subsequent innate immune activation...
  57. pmc Carcinoma-produced factors activate myeloid cells through TLR2 to stimulate metastasis
    Sunhwa Kim
    Department of Pharmacology and Cancer Center, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093 0723, USA
    Nature 457:102-6. 2009
    ..These results explain how advanced cancer cells usurp components of the host innate immune system, including bone-marrow-derived myeloid progenitors, to generate an inflammatory microenvironment hospitable for metastatic growth...
  58. ncbi TLR6: A novel member of an expanding toll-like receptor family
    O Takeuchi
    Department of Biochemistry, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya, Hyogo 663 8501, Japan
    Gene 231:59-65. 1999
    ..The TLR6 gene, as well as the TLR1 gene, mapped to the proximal region of murine chromosome 5 within 1.7cM of each other...
  59. doi Pathogen recognition in the innate immune response
    Himanshu Kumar
    Laboratory of Host Defense, WPI Immunology Frontier Research Center, Osaka University, 3 1 Yamada oka, Suita, Osaka 565 0871, Japan
    Biochem J 420:1-16. 2009
    ..In the present review, we will discuss the recent progress in the study of pathogen recognition by TLRs, RLRs and NLRs and their signalling pathways...
  60. pmc TLR-dependent control of Francisella tularensis infection and host inflammatory responses
    Allison L Abplanalp
    Department of Microbiology and Immunology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America
    PLoS ONE 4:e7920. 2009
    ..tularensis PAMPs are predominantly recognized by TLR2/TLR1 or TLR2/TLR6...
  61. pmc TLR2 activation inhibits embryonic neural progenitor cell proliferation
    Eitan Okun
    Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, Maryland 21224, USA
    J Neurochem 114:462-74. 2010
    ..TLR2-mediated inhibition of NPC proliferation may therefore be a mechanism by which infection, ischemia, and inflammation adversely affect brain development...
  62. doi A recombinant lipoprotein containing an unsaturated fatty acid activates NF-kappaB through the TLR2 signaling pathway and induces a differential gene profile from a synthetic lipopeptide
    Chih Hsiang Leng
    Vaccine Research and Development Center, National Health Research Institutes, Taiwan
    Mol Immunol 47:2015-21. 2010
    ..After analyzing the co-receptor usage of TLR2 using TLR1(-/-) or TLR6(-/-) mice, the TLR2 signaling triggered by rlipo-D1E3 and Pam3 could use either TLR1 or TLR6 as a co-..
  63. pmc Atherogenic lipids and lipoproteins trigger CD36-TLR2-dependent apoptosis in macrophages undergoing endoplasmic reticulum stress
    Tracie A Seimon
    Department of Medicine, Columbia University, New York, NY 10032, USA
    Cell Metab 12:467-82. 2010
    ..These findings provide insight into how atherogenic lipoproteins trigger macrophage apoptosis in the setting of ER stress and how TLR activation might promote macrophage apoptosis and plaque necrosis in advanced atherosclerosis...
  64. doi Phosphatidylinositol 3-kinase activation attenuates the TLR2-mediated macrophage proinflammatory cytokine response to Francisella tularensis live vaccine strain
    Edward A Medina
    Department of Microbiology and Immunology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    J Immunol 185:7562-72. 2010
    ..This TLR2-independent inhibitory pathway may be an important mechanism by which Francisella suppresses the host's innate immune response...

Research Grants8

  1. Atherosclerosis in Beige(Lyst) Mutant
    Linda Curtiss; Fiscal Year: 2006
    ..The power of comparing LDLr- /-bg with LDLr-/- mice will allow us to focus on those cellular activities that are physiologically relevant and participate in vivo in a very complex and still poorly understood disease process. ..
  2. Toll Receptors in Atherosclerosis
    Linda Curtiss; Fiscal Year: 2008
    ..We will identify candidate endogenous proatherogenic agonists and define the role of the TLR2 co-receptors, TLR1, TLR6, CD14 and and CD36, in TLR2 signaling. In Aim 2 we will study exogenous agonists of TLR2...
  3. IMMUNOCHEMICAL STRUCTURE/FUNCTION OF APOLIPOPROTEIN A-I
    Linda Curtiss; Fiscal Year: 2008
    ..We propose that core lipid reduction by triglyceride hydrolysis and remodeling by PLTP and CETP release lipid-poor apoAI from HDL to facilitate efflux from Mphi foam cells within atherosclerotic lesions. ..
  4. Genes that Mediate Tolerance to the Placental Allograft
    Bruce Beutler; Fiscal Year: 2006
    ..Fourth, circumvention of the toleragenic mechanism might be used to prevent normal gestation, leading to termination of pregnancy within a few days following implantation of the blastocyst. ..
  5. Forward Genetic Analysis of the Innate Immune Contribution to MCMV Resistance
    Bruce Beutler; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  6. Mutagenic analysis of LPS responses
    Bruce Beutler; Fiscal Year: 2006
    ..In the case of mutations that abolish LPS tolerance, we will attempt to determine the net impact on host resistance to infection. ..
  7. TLR4 as an LPS sendor and susceptibility locus
    Bruce Beutler; Fiscal Year: 2007
    ..The new mutations that are found--and those that have already been found in preliminary efforts--will be isolated by positional cloning. ..
  8. B1B lymphocytes generate T cell-independent memory
    KISHORE ALUGUPALLI; Fiscal Year: 2009
    ..Understanding the basis for the longevity of the Tl protective responses conferred by B1b cells will provide novel approaches to generate effective vaccines against pathogens expressing Tl antigens. ..