Gene Symbol: Tigd4
Description: tigger transposable element derived 4
Alias: C130063O11Rik, Gm418, tigger transposable element-derived protein 4
- FBXW7 mutations typically found in human cancers are distinct from null alleles and disrupt lung developmentHayley Davis
Molecular and Population Genetics Laboratory, Wellcome Trust Centre for Human Genetics, Oxford University, Roosevelt Drive, Oxford OX3 7BN, UK
J Pathol 224:180-9. 2011..Fbxw7(R482Q) alleles are not functionally equivalent to heterozygous or homozygous null alleles, and we propose that they are selected in tumourigenesis because they cause a selective or partial loss of FBXW7 function...