Ticam2

Summary

Gene Symbol: Ticam2
Description: toll-like receptor adaptor molecule 2
Alias: B430113A10, TICAM-2, TRAM, Tirp, Trif, TIR domain-containing adapter molecule 2, TIR domain-containing adapter protein, TRIF-related adapter molecule TRAM, TRIF-related adaptor molecule, Toll-interleukin I receptor domain (TIR)-containing adaptor molecule (TICAM) 2, toll/interleukin-1 receptor domain-containing protein
Species: mouse

Top Publications

  1. ncbi Regulation of lipopolysaccharide-inducible genes by MyD88 and Toll/IL-1 domain containing adaptor inducing IFN-beta
    Tomonori Hirotani
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamada oka, Suita, Osaka 565 0871, Japan
    Biochem Biophys Res Commun 328:383-92. 2005
  2. pmc Lipopolysaccharide potentiates effector T cell accumulation into nonlymphoid tissues through TRIF
    Jeremy P McAleer
    Department of Immunology, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    J Immunol 182:5322-30. 2009
  3. doi Akt contributes to activation of the TRIF-dependent signaling pathways of TLRs by interacting with TANK-binding kinase 1
    Sun Myung Joung
    School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju, Korea
    J Immunol 186:499-507. 2011
  4. pmc LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF
    Katherine A Fitzgerald
    Division of Infectious Disease and Immunology, Department of Medicine, The University of Massachusetts Medical School, Worcester, MA 01605, USA
    J Exp Med 198:1043-55. 2003
  5. pmc Host innate recognition of an intestinal bacterial pathogen induces TRIF-dependent protective immunity
    John Sotolongo
    Division of Gastroenterology, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    J Exp Med 208:2705-16. 2011
  6. pmc DDX1, DDX21, and DHX36 helicases form a complex with the adaptor molecule TRIF to sense dsRNA in dendritic cells
    Zhiqiang Zhang
    Department of Immunology, Center for Cancer Immunology Research, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Immunity 34:866-78. 2011
  7. pmc HMBG1 mediates ischemia-reperfusion injury by TRIF-adaptor independent Toll-like receptor 4 signaling
    Qing wu Yang
    Department of Neurology, Daping Hospital, The Third Military Medical University, Yuzhong District, Chongqing, China
    J Cereb Blood Flow Metab 31:593-605. 2011
  8. pmc TRIF modulates TLR5-dependent responses by inducing proteolytic degradation of TLR5
    Yoon Jeong Choi
    Division of Digestive Diseases, David Geffen School of Medicine, UCLA, Los Angeles, California 90095, USA
    J Biol Chem 285:21382-90. 2010
  9. pmc Both TRIF- and MyD88-dependent signaling contribute to host defense against pulmonary Klebsiella infection
    Shanshan Cai
    Department of Pathobiological Sciences, Louisiana State University, Baton Rouge, LA 70803, USA
    J Immunol 183:6629-38. 2009
  10. pmc TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta
    Jonathan C Kagan
    Howard Hughes Medical Institute and Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Nat Immunol 9:361-8. 2008

Research Grants

  1. Donor Antigen-Induced Peripheral Tolerance
    Dianne McKay; Fiscal Year: 2006
  2. Innate immune responses in lymphatic filariasis
    AMY HISE; Fiscal Year: 2007
  3. B1B lymphocytes generate T cell-independent memory
    KISHORE ALUGUPALLI; Fiscal Year: 2009

Scientific Experts

  • Hidenori Ohnishi
  • Willem J Wiersinga
  • Qing wu Yang
  • Dianne McKay
  • AMY HISE
  • KISHORE ALUGUPALLI
  • Jonathan C Kagan
  • Anke Leichtle
  • Subhra K Biswas
  • Hang Zhao
  • Shizuo Akira
  • Carmelo Biondo
  • Katherine A Fitzgerald
  • Masahiro Yamamoto
  • Jose Ruiz
  • Giuseppe Teti
  • Giuseppe Mancuso
  • Concetta Beninati
  • Roberta Galbo
  • Angelina Midiri
  • Alessandro Costa
  • Douglas T Golenbock
  • Vijay A K Rathinam
  • Do Wan Shim
  • Ji Won Han
  • Saravana Kanagavelu
  • Masayuki Fukata
  • Silvia Bozza
  • Antonio Malara
  • Giacomo Signorino
  • Daniel C Rowe
  • Nastaran Mohammadi
  • Sushruta Koppula
  • Tae Bong Kang
  • Brian G Monks
  • Laura Romero
  • S Kanagavelu
  • Claudia Flores
  • Reldy Riveron
  • J M Termini
  • Shuang Zhang
  • Kwang Ho Lee
  • Tae Hyoun Kim
  • Osamu Takeuchi
  • Eicke Latz
  • Joseph P Kolb
  • Anne F McGettrick
  • Su Yu Tsai
  • Qiang Guo
  • Patrizia Loi
  • Kurt Schesser
  • Anna M Lundberg
  • Amy C Wollish
  • Wenji Piao
  • Maria Pihlgren
  • Eric B Brandt
  • Joel D Schilling
  • Elena Tonti
  • Sen Lin
  • Agostinho Carvalho
  • Luigina Romani
  • Salvatore Papasergi
  • Francesco Cardile
  • Michael T Berton
  • Stefanie N Vogel
  • Ian R Morris
  • Miriam H P van Lieshout
  • Camille Aubry
  • Eric D Abston
  • Shahla Abdollahi-Roodsaz
  • Keri B Vartanian
  • Zhaohui Xu
  • John Sotolongo
  • Zhiqiang Zhang
  • Nicholas Arpaia
  • Sara M Hoffman
  • Julia Reis
  • Sun Myung Joung
  • Sergey S Seregin
  • Timothy E Sweeney
  • Sheila Donnelly
  • Antonella De Luca
  • Chiquita Palha De Sousa
  • Petra Gais
  • Tatyana Lysakova-Devine
  • Yoon Jeong Choi
  • Shijun Wang
  • Daniel M Appledorn
  • Bettina M Buchholz
  • Andrea Amalfitano

Detail Information

Publications88

  1. ncbi Regulation of lipopolysaccharide-inducible genes by MyD88 and Toll/IL-1 domain containing adaptor inducing IFN-beta
    Tomonori Hirotani
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamada oka, Suita, Osaka 565 0871, Japan
    Biochem Biophys Res Commun 328:383-92. 2005
    ..via TIR domain containing adaptor molecules, MyD88, and Toll/IL-1 domain containing adaptor inducing IFN-beta (TRIF)...
  2. pmc Lipopolysaccharide potentiates effector T cell accumulation into nonlymphoid tissues through TRIF
    Jeremy P McAleer
    Department of Immunology, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    J Immunol 182:5322-30. 2009
    ..survival and Th1 differentiation by stimulating MyD88 and Toll/IL-1R domain-containing adaptor-inducing IFN-beta (TRIF) signaling pathways...
  3. doi Akt contributes to activation of the TRIF-dependent signaling pathways of TLRs by interacting with TANK-binding kinase 1
    Sun Myung Joung
    School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju, Korea
    J Immunol 186:499-507. 2011
    Toll/IL-1R domain-containing adaptor inducing IFN-β (TRIF) is an adaptor molecule that is recruited to TLR3 and -4 upon agonist stimulation and triggers activation of IFN regulatory factor 3 (IRF3) and expression of type 1 IFNs, which ..
  4. pmc LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF
    Katherine A Fitzgerald
    Division of Infectious Disease and Immunology, Department of Medicine, The University of Massachusetts Medical School, Worcester, MA 01605, USA
    J Exp Med 198:1043-55. 2003
    Toll-IL-1-resistance (TIR) domain-containing adaptor-inducing IFN-beta (TRIF)-related adaptor molecule (TRAM) is the fourth TIR domain-containing adaptor protein to be described that participates in Toll receptor signaling...
  5. pmc Host innate recognition of an intestinal bacterial pathogen induces TRIF-dependent protective immunity
    John Sotolongo
    Division of Gastroenterology, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    J Exp Med 208:2705-16. 2011
    ..differentiation factor 88 (MyD88) and toll/interleukin 1 receptor domain-containing adapter inducing IFN-β (TRIF), is required for protection against Gram-negative bacteria...
  6. pmc DDX1, DDX21, and DHX36 helicases form a complex with the adaptor molecule TRIF to sense dsRNA in dendritic cells
    Zhiqiang Zhang
    Department of Immunology, Center for Cancer Immunology Research, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Immunity 34:866-78. 2011
    ..identification of a viral sensor, consisting of RNA helicases DDX1, DDX21, and DHX36, and the adaptor molecule TRIF, by isolation and sequencing of poly I:C-binding proteins in myeloid dendritic cells (mDCs)...
  7. pmc HMBG1 mediates ischemia-reperfusion injury by TRIF-adaptor independent Toll-like receptor 4 signaling
    Qing wu Yang
    Department of Neurology, Daping Hospital, The Third Military Medical University, Yuzhong District, Chongqing, China
    J Cereb Blood Flow Metab 31:593-605. 2011
    ..model with Toll/interleukin-1 receptor domain-containing adaptor-inducing interferon-β knockout mice (TRIF(-/-)) and evaluated the activity and expression of TRIF pathway-related kinases...
  8. pmc TRIF modulates TLR5-dependent responses by inducing proteolytic degradation of TLR5
    Yoon Jeong Choi
    Division of Digestive Diseases, David Geffen School of Medicine, UCLA, Los Angeles, California 90095, USA
    J Biol Chem 285:21382-90. 2010
    ..Here we show that the TIR domain containing adaptor-inducing interferon-beta (TRIF), an adaptor molecule mediating TLR3 signaling and MyD88-independent signaling of TLR4, plays an inhibitory role in ..
  9. pmc Both TRIF- and MyD88-dependent signaling contribute to host defense against pulmonary Klebsiella infection
    Shanshan Cai
    Department of Pathobiological Sciences, Louisiana State University, Baton Rouge, LA 70803, USA
    J Immunol 183:6629-38. 2009
    Klebsiella pneumoniae causes extensive lung damage. TLR signaling involves adaptors TRIF and MyD88. However, the relative contribution of TRIF and MyD88 signaling in host defense against pulmonary K...
  10. pmc TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta
    Jonathan C Kagan
    Howard Hughes Medical Institute and Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Nat Immunol 9:361-8. 2008
    Toll-like receptor 4 (TLR4) induces two distinct signaling pathways controlled by the TIRAP-MyD88 and TRAM-TRIF pairs of adaptor proteins, which elicit the production of proinflammatory cytokines and type I interferons, respectively...
  11. doi Roles for LPS-dependent interaction and relocation of TLR4 and TRAM in TRIF-signaling
    Natsuko Tanimura
    Department of Microbiology and Immunology, Division of Infectious Genetics, The Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Minatoku, Tokyo 108 8639, Japan
    Biochem Biophys Res Commun 368:94-9. 2008
    ..MyD88 and TIRAP/Mal are essential adaptor molecules for the former but not for the latter pathway. In contrast, TRIF/TICAM-1 and TRAM/TICAM-2 are essential for both...
  12. ncbi Role for MyD88-independent, TRIF pathway in lipid A/TLR4-induced endotoxin tolerance
    Subhra K Biswas
    Singapore Immunology Network, Biomedical Sciences Institutes, Agency for Science, Technology and Research, Immunos
    J Immunol 179:4083-92. 2007
    ..We investigated the role of the TRIF/IFN-beta pathway in TLR4-induced endotoxin tolerance...
  13. ncbi Selective use of TRAM in lipopolysaccharide (LPS) and lipoteichoic acid (LTA) induced NF-kappaB activation and cytokine production in primary human cells: TRAM is an adaptor for LPS and LTA signaling
    Sandra M Sacre
    Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College of Science, Technology and Medicine, London, United Kingdom
    J Immunol 178:2148-54. 2007
    ..One of these adaptors, Toll-IL-1R domain-containing adaptor inducing IFN-beta-related adaptor molecule (TRAM), has been shown to be essential for TLR4 signaling in TRAM(-/-) mice and cell lines...
  14. ncbi TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling
    Liang Hua Bin
    Department of Immunology, National Jewish Medical and Research Center, University of Colorado Health Sciences Center, Denver 80206, USA
    J Biol Chem 278:24526-32. 2003
    ..In this report, we identified a novel TIR domain-containing adapter protein designated as TIRP. Co-immunoprecipitation experiments suggest that TIRP is associated with IL-1 receptors...
  15. ncbi TIR-containing adapter molecule (TICAM)-2, a bridging adapter recruiting to toll-like receptor 4 TICAM-1 that induces interferon-beta
    Hiroyuki Oshiumi
    Department of Immunology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Higashinari ku, Osaka 537 8511, Japan
    J Biol Chem 278:49751-62. 2003
    ..TICAM-1/TRIF was identified as an adapter that facilitates activation of IRF-3 followed by expression of interferon (IFN)-beta ..
  16. ncbi TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway
    Masahiro Yamamoto
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamada oka, Suita Osaka 565 0871, Japan
    Nat Immunol 4:1144-50. 2003
    ..pathways mediated by Toll-interleukin 1 receptor (TIR) domain-containing adaptors such as MyD88, TIRAP and TRIF. MyD88 is a common adaptor that is essential for proinflammatory cytokine production, whereas TRIF mediates the ..
  17. pmc Trif-related adapter molecule is phosphorylated by PKC{epsilon} during Toll-like receptor 4 signaling
    Anne F McGettrick
    School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland
    Proc Natl Acad Sci U S A 103:9196-201. 2006
    ..Mal), Toll/IL-1R domain-containing adapter inducing IFN-beta (Trif), and Trif-related adapter molecule (TRAM). Here we show that TRAM is transiently phosphorylated by PKCepsilon on serine-16 in an LPS-dependent manner...
  18. ncbi RIP1 is an essential mediator of Toll-like receptor 3-induced NF-kappa B activation
    Etienne Meylan
    Department of Biochemistry, University of Lausanne, BIL Biomedical Research Center, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Nat Immunol 5:503-7. 2004
    ..innate immune responses through Toll-interleukin 1 receptor (TIR) domain-containing adaptors such as MyD88 and Trif. Analysis of Trif-deficient mice has shown that TLR3-dependent activation of the transcription factor NF-kappa B by ..
  19. pmc The myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transduction
    Daniel C Rowe
    Division of Infectious Disease and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Proc Natl Acad Sci U S A 103:6299-304. 2006
    b>TRIF-related adaptor molecule (TRAM) is the fourth Toll/IL-1 resistance domain-containing adaptor to be described that participates in Toll-like receptor (TLR) signaling. TRAM functions exclusively in the TLR4 pathway...
  20. pmc Neutrophils Directly Recognize Group B Streptococci and Contribute to Interleukin-1β Production during Infection
    Nastaran Mohammadi
    Department of Clinical and Experimental Medicine, University of Messina, 98125, Messina, Italy
    PLoS ONE 11:e0160249. 2016
    ..These cells directly recognize GBS by means of endosomal TLRs and cytosolic sensors, leading to activation of the caspase-1 inflammasome. ..
  21. doi A novel synthetic derivative of melatonin, 5-hydroxy-2'-isobutyl-streptochlorin (HIS), inhibits inflammatory responses via regulation of TRIF-dependent signaling and inflammasome activation
    Do Wan Shim
    Department of Biotechnology, Research Institute of Inflammatory Disease, Konkuk University, Chungju, Republic of Korea
    Toxicol Appl Pharmacol 284:227-35. 2015
    ..effects of HIS were mediated through the regulation of the TIR domain-containing, adaptor-inducing, interferon-β (TRIF)-dependent signaling pathway from toll-like receptors...
  22. pmc Type I interferon signaling contributes to the bias that Toll-like receptor 4 exhibits for signaling mediated by the adaptor protein TRIF
    Joseph P Kolb
    Department of Microbiology and Immunology, University of Louisville School of Medicine, 570 South Preston Street, Louisville, KY 40202, USA Institute for Cellular Therapeutics, University of Louisville School of Medicine, Louisville, KY 40202, USA
    Sci Signal 7:ra108. 2014
    ..marker 88 (MyD88) or Toll-interleukin-1 (IL-1) receptor (TIR) domain-containing adaptor inducing interferon-β (TRIF)...
  23. pmc TIR-domain-containing adapter-inducing interferon-β (TRIF) regulates Th17-mediated intestinal immunopathology in colitis
    S Kanagavelu
    1 Division of Gastroenterology, Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida, USA 2 Division of Gastroenterology, Department of Medicine, F Widjaja Foundation, Inflammatory Bowel and Immunology Research Institute, Cedars Sinai Medical Center, Los Angeles, California, USA
    Mucosal Immunol 8:296-306. 2015
    ..Here we show that innate TRIF signaling regulates intestinal Th17-cell generation and plasticity during colitis...
  24. doi PTX3 binds MD-2 and promotes TRIF-dependent immune protection in aspergillosis
    Silvia Bozza
    Department of Experimental Medicine, University of Perugia, Perugia 06132, Italy
    J Immunol 193:2340-8. 2014
    ..fumigatus infection. ..
  25. doi Toll-like receptor 3 and 4 signalling through the TRIF and TRAM adaptors in haematopoietic cells promotes atherosclerosis
    Anna M Lundberg
    Center for Molecular Medicine, Department of Medicine at Karolinska University Hospital Solna, Karolinska Institutet, Stockholm SE 17176, Sweden
    Cardiovasc Res 99:364-73. 2013
    ..in immune cells are pro-atherogenic, we analysed the role of the TLR-specific adaptors MyD88 adaptor-like (MAL), TRIF-related adaptor molecule (TRAM), and TIR-domain-containing adaptor-inducing interferon-β (TRIF) in atherosclerosis.
  26. pmc TLR signaling is required for Salmonella typhimurium virulence
    Nicholas Arpaia
    Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720 3200, USA
    Cell 144:675-88. 2011
    ..Our results indicate that S. typhimurium requires cues from the innate immune system to regulate virulence genes necessary for intracellular survival, growth, and systemic infection...
  27. pmc MyD88-dependent IL-1 receptor signaling is essential for gouty inflammation stimulated by monosodium urate crystals
    Chun Jen Chen
    Department of Pathology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Clin Invest 116:2262-71. 2006
    ..In contrast, other TIR adaptor molecules, TIRAP/Mal, TRIF, and TRAM, are not required for this process...
  28. pmc Systemic Activation of TLR3-Dependent TRIF Signaling Confers Host Defense against Gram-Negative Bacteria in the Intestine
    Jose Ruiz
    Division of Gastroenterology, Department of Medicine, University of Miami Miller School of Medicine Miami, FL, USA
    Front Cell Infect Microbiol 5:105. 2015
    Recognition of Gram-negative bacteria by toll-like receptor (TLR)4 induces MyD88 and TRIF mediated responses. We have shown that TRIF-dependent responses play an important role in intestinal defense against Gram-negative enteropathogens...
  29. pmc Annexin A2 binds to endosomes and negatively regulates TLR4-triggered inflammatory responses via the TRAM-TRIF pathway
    Shuang Zhang
    Department of Basic Sciences, University of North Dakota, Grand Forks, North Dakota 58203 9037, USA
    Sci Rep 5:15859. 2015
    ..It activated the TRAM-dependent endosomal signaling, leading to the release of anti-inflammatory cytokines...
  30. pmc TIR Domain-Containing Adapter-Inducing Beta Interferon (TRIF) Mediates Immunological Memory against Bacterial Pathogens
    Saravana Kanagavelu
    Division of Gastroenterology, Department of Medicine, Inflammatory Bowel and Immunobiology Research Institute, Cedars Sinai Medical Center, Los Angeles, California, USA
    Infect Immun 83:4404-15. 2015
    ..in which innate and adaptive immunity are linked by TIR domain-containing adapter-inducing beta interferon (TRIF) during establishment and reactivation of memory T cells against Gram-negative enteropathogens...
  31. doi Syneilesis palmata (Thunb.) Maxim. extract attenuates inflammatory responses via the regulation of TRIF-dependent signaling and inflammasome activation
    Ji Won Han
    Department of Biotechnology, College of Biomedical and Health Science, Research Institute of Inflammatory Diseases, Konkuk University, Chungju, South Korea
    J Ethnopharmacol 166:1-4. 2015
    ..This study provides the scientific basis for the anti-inflammatory effects of S. palmata extract (SP) in both in vitro and in vivo experimental models...
  32. doi Critical role of TRIF and MyD88 in Mycobacterium tuberculosis Hsp70-mediated activation of dendritic cells
    Tae Hyoun Kim
    Laboratory Animal Medicine, College of Veterinary Medicine, Seoul University, Seoul 151 742, Republic of Korea
    Cytokine 71:139-44. 2015
    ..In this study, we examined whether TRIF and MyD88, the core adaptor molecules for TLRs signaling, regulate Mtb Hsp70-induced DCs activation...
  33. pmc DAMP molecule S100A9 acts as a molecular pattern to enhance inflammation during influenza A virus infection: role of DDX21-TRIF-TLR4-MyD88 pathway
    Su Yu Tsai
    Department of Microbiology and Immunology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America
    PLoS Pathog 10:e1003848. 2014
    ..Genetic studies showed that the DDX21-TRIF signaling pathway is required for S100A9 gene expression/production during infection...
  34. pmc Recruitment of TLR adapter TRIF to TLR4 signaling complex is mediated by the second helical region of TRIF TIR domain
    Wenji Piao
    Departments of Microbiology and Immunology, Medicine, and Microbiology and Immunology, and Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD 21201
    Proc Natl Acad Sci U S A 110:19036-41. 2013
    ..Immunoprecipitation assays demonstrated that TF4 binds to TLR4 but not TRIF-related adaptor molecule (TRAM), whereas TF5 binds to TRAM strongly and TLR4 to a lesser extent...
  35. pmc Bisphosphonates target B cells to enhance humoral immune responses
    Elena Tonti
    Division of Immunology, Transplantation and Infectious Diseases, San Raffaele Scientific Institute, 20132 Milan, Italy Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA
    Cell Rep 5:323-30. 2013
    ..Rather, bisphosphonates target directly B cells and enhance B cell expansion and antibody production upon antigen encounter. These data establish bisphosphonates as an additional class of adjuvants that boost humoral immune responses...
  36. pmc Exacerbation of allergen-induced eczema in TLR4- and TRIF-deficient mice
    Eric B Brandt
    Division of Asthma Research, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229
    J Immunol 191:3519-25. 2013
    ..MyD88, TLR4, or Toll-IL-1R domain-containing adapter-inducing IFN-β (TRIF)-deficient and wild-type mice were epicutaneously exposed to Aspergillus fumigatus allergen over 3 wk...
  37. pmc TRIF licenses caspase-11-dependent NLRP3 inflammasome activation by gram-negative bacteria
    Vijay A K Rathinam
    Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Cell 150:606-19. 2012
    ..Here, we identify a TRIF pathway that licenses NLRP3 inflammasome activation by all Gram-negative bacteria...
  38. pmc LPS preconditioning redirects TLR signaling following stroke: TRIF-IRF3 plays a seminal role in mediating tolerance to ischemic injury
    Keri B Vartanian
    Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, 97239, USA
    J Neuroinflammation 8:140. 2011
    ..Here we define several molecular mediators of the primary signaling cascades induced by LPS preconditioning that give rise to the reprogrammed response to cerebral ischemia and confer the neuroprotective phenotype...
  39. doi Recognition of fungal RNA by TLR7 has a nonredundant role in host defense against experimental candidiasis
    Carmelo Biondo
    The Elie Metchnikoff Department, University of Messina, Messina, Italy
    Eur J Immunol 42:2632-43. 2012
    ..This pathway differs from those involved in IL-23 or TNF-α responses, which we show here to be independent from translocation of intracellular TLRs, phagocytosis, or phagosomal acidification...
  40. pmc TRAM is involved in IL-18 signaling and functions as a sorting adaptor for MyD88
    Hidenori Ohnishi
    Department of Pediatrics, Graduate School of Medicine, Gifu University, Gifu, Japan
    PLoS ONE 7:e38423. 2012
    ..In this study, a direct interaction between MyD88-TIR and another membrane-sorting adaptor, TRAM/TICAM-2, was demonstrated in vitro...
  41. pmc Both TLR2 and TRIF contribute to interferon-β production during Listeria infection
    Camille Aubry
    Institut Pasteur, Unité des Interactions Bactéries Cellules, Paris, France
    PLoS ONE 7:e33299. 2012
    ..Induction of IFN-β was independent of the Mal/TIRAP adaptor protein but required TRIF and the transcription factors IRF3 and IRF7. These pathways were stimulated to a lesser degree by wild-type L...
  42. pmc Microglial TIR-domain-containing adapter-inducing interferon-β (TRIF) deficiency promotes retinal ganglion cell survival and axon regeneration via nuclear factor-κB
    Sen Lin
    Department of Neurobiology, Chongqing Key Laboratory of Neurobiology, Third Military Medical University, Chongqing 400038, PR China
    J Neuroinflammation 9:39. 2012
    TIR-domain-containing adapter-inducing interferon-β (TRIF) is the sole downstream adaptor of Toll-like receptor (TLR)3, which is one of the major signaling pathways in immune cells leading to neuroinflammation in the central nervous ..
  43. pmc Activation of the NLRP3 inflammasome by group B streptococci
    Alessandro Costa
    Elie Metchnikoff Department, University of Messina, Messina I 98125, Italy
    J Immunol 188:1953-60. 2012
    ..Our data link the production of a major virulence factor by GBS with the activation of a highly effective anti-GBS response triggered by the NLRP3 inflammasome...
  44. doi Destructive role of myeloid differentiation factor 88 and protective role of TRIF in interleukin-17-dependent arthritis in mice
    Shahla Abdollahi-Roodsaz
    Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Arthritis Rheum 64:1838-47. 2012
    ..of the two signaling pathways used by TLRs, which are mediated by myeloid differentiation factor 88 (MyD88) and TRIF, remains unclear...
  45. pmc Th2 regulation of viral myocarditis in mice: different roles for TLR3 versus TRIF in progression to chronic disease
    Eric D Abston
    Department of Environmental Health Sciences, Johns Hopkins University Bloomberg School of Public Health, 615 N Wolfe Street, Baltimore, MD 21205, USA
    Clin Dev Immunol 2012:129486. 2012
    ..Here, we investigated the role of virus-activated Toll-like receptor (TLR)3 and its adaptor TRIF on the development of autoimmune coxsackievirus B3 (CVB3) myocarditis in mice...
  46. doi Conditional transgenic expression of TIR-domain-containing adaptor-inducing interferon-β (TRIF) in the adult mouse heart is protective in acute viral myocarditis
    Zhaohui Xu
    Department of Pediatrics, Baylor College of Medicine and Texas Children s Hospital, 1102 Bates Street, FC 430 09, Houston, TX 77030, USA
    Basic Res Cardiol 106:1159-71. 2011
    TIR-domain-containing adaptor-inducing interferon-β (TRIF) plays a major role in Toll-like receptor 3 (TLR3) mediated signaling...
  47. doi Differential roles of MyD88 and TRIF in hematopoietic and resident cells during murine gram-negative pneumonia
    Miriam H P van Lieshout
    Center of Infection and Immunity, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Infect Dis 206:1415-23. 2012
    ..differentiation primary response gene (88) (MyD88) and TIR-domain-containing adaptor-inducing interferon-β (TRIF)...
  48. doi Interferon regulatory factor 3 deficiency leads to interleukin-17-mediated liver ischemia-reperfusion injury
    Patrizia Loi
    Institut d Immunologie Médicale, Universite Libre de Bruxelles, Gosselies, Belgium
    Hepatology 57:351-61. 2013
    ....
  49. pmc An attenuating mutation in a neurovirulent Sindbis virus strain interacts with the IPS-1 signaling pathway in vivo
    Amy C Wollish
    Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Virology 435:269-80. 2013
    ..b>TRIF dependent signaling played a modest role in protecting against disease by both S300 and nsP1 T538I, but did not ..
  50. doi TLR4- and TRIF-dependent stimulation of B lymphocytes by peptide liposomes enables T cell-independent isotype switch in mice
    Maria Pihlgren
    AC Immune SA, Parc Scientifique EPFL B, Swiss Federal Institute of Technology EPFL, Lausanne, Switzerland
    Blood 121:85-94. 2013
    ..Surprisingly, the IgG class switch was mediated by TIR-domain-containing adapter inducing interferon-β (TRIF), but not by MyD88...
  51. pmc TLR4 activation under lipotoxic conditions leads to synergistic macrophage cell death through a TRIF-dependent pathway
    Joel D Schilling
    Diabetic Cardiovascular Disease Center, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 190:1285-96. 2013
    ..Instead, we uncovered a macrophage death pathway that required TLR4 signaling via TRIF but was independent of NF-κB, MAPKs, and IRF3...
  52. ncbi MyD88- and Bruton's tyrosine kinase-mediated signals are essential for T cell-independent pathogen-specific IgM responses
    Kishore R Alugupalli
    Department of Microbiology and Immunology and Kimmel Cancer Center, Thomas Jefferson University, 233 South 10th Street, Philadelphia, PA 19107, USA
    J Immunol 178:3740-9. 2007
    ..These results suggest that MyD88 specifically promotes T cell-independent BCR signaling and that, in the absence of Btk, this TLR-mediated stimulation is a required component of this signal...
  53. ncbi Vesicular stomatitis virus glycoprotein G activates a specific antiviral Toll-like receptor 4-dependent pathway
    Philippe Georgel
    Department of Immunology, The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, CA 92037, USA
    Virology 362:304-13. 2007
    ..essential for the induction of a previously unrecognized CD14/TLR4-dependent response pathway in which the adapter TRAM has predominant importance, absent any need for MyD88 or Mal, and with only a partial requirement for TRIF...
  54. ncbi Simultaneous deletion of MyD88 and Trif delays major histocompatibility and minor antigen mismatch allograft rejection
    Dianne McKay
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Eur J Immunol 36:1994-2002. 2006
    ..Using mice with deletions of the proximal TLR adapter proteins MyD88 or Trif, and those with simultaneous deletions of both MyD88 and Trif, we demonstrated that absence of both MyD88 and Trif ..
  55. pmc Type I interferon signaling is required for activation of the inflammasome during Francisella infection
    Thomas Henry
    Department of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA
    J Exp Med 204:987-94. 2007
    ..This connection underscores the importance of the cytosolic recognition of pathogens and highlights how multiple innate immunity pathways interact before commitment to critical host responses...
  56. ncbi Innate immune responses to endosymbiotic Wolbachia bacteria in Brugia malayi and Onchocerca volvulus are dependent on TLR2, TLR6, MyD88, and Mal, but not TLR4, TRIF, or TRAM
    Amy G Hise
    Center for Global Health and Diseases and Department of Ophthalmology, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA
    J Immunol 178:1068-76. 2007
    ..These results establish that the innate inflammatory pathways activated by endosymbiotic Wolbachia in B. malayi and O. volvulus filaria are dependent on TLR2-TLR6 interactions and are mediated by adaptor molecules MyD88 and TIRAP/Mal...
  57. ncbi Virulence factors of Yersinia pestis are overcome by a strong lipopolysaccharide response
    Sara W Montminy
    Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Nat Immunol 7:1066-73. 2006
    ..pestis virulence. Evading TLR4 activation by lipid A alteration may contribute to the virulence of various Gram-negative bacteria...
  58. pmc A toll-like receptor 2 pathway regulates the Ppargc1a/b metabolic co-activators in mice with Staphylococcal aureus sepsis
    Timothy E Sweeney
    Department of Pathology, Duke University Medical Center, Durham, North Carolina, United States of America
    PLoS ONE 6:e25249. 2011
    ..and MAL-deficient mice expressed hepatic Ppargc1a and Ppargc1b normally, but that neither gene was activated in TRAM-deficient mice...
  59. doi TRIF signaling stimulates translation of TNF-alpha mRNA via prolonged activation of MK2
    Petra Gais
    Department of Surgery, Technical University of Munich, Munich, Germany
    J Immunol 184:5842-8. 2010
    The adapter protein TRIF mediates signal transduction through TLR3 and TLR4, inducing production of type I IFNs and inflammatory cytokines...
  60. pmc MyD88 dependent signaling contributes to protective host defense against Burkholderia pseudomallei
    W Joost Wiersinga
    Center for Infection and Immunity Amsterdam CINIMA, Academic Medical Center, Amsterdam, The Netherlands
    PLoS ONE 3:e3494. 2008
    ..differentiation primary-response gene 88 (MyD88) and TIR-domain-containing adaptor protein inducing IFNbeta (TRIF) are regarded as the key signaling adaptor proteins for TLRs...
  61. pmc The RNA-activated protein kinase enhances the induction of interferon-beta and apoptosis mediated by cytoplasmic RNA sensors
    Christopher S McAllister
    Department of Molecular, Cellular and Developmental Biology, University of California, Santa Barbara, California 93106, USA
    J Biol Chem 284:1644-51. 2009
    ..IPS-1 adaptor cytosolic pathway and the Toll-like receptor 3 and TIR domain-containing adaptor-inducing IFN-beta (TRIF) adaptor membrane-associated pathway, both of which activate IFN regulatory factor 3 (IRF3)...
  62. pmc Campylobacter jejuni-induced activation of dendritic cells involves cooperative signaling through Toll-like receptor 4 (TLR4)-MyD88 and TLR4-TRIF axes
    Vijay A K Rathinam
    Comparative Enteric Diseases Laboratory, National Food Safety and Toxicology Center, Michigan State University, East Lansing, MI 48824, USA
    Infect Immun 77:2499-507. 2009
    ..88 (MyD88) and/or Toll-interleukin 1 (IL-1) receptor domain-containing adaptor-inducing beta interferon (IFN-beta) (TRIF) is critical in inducing immunity against pathogens...
  63. doi MAPPIT (mammalian protein-protein interaction trap) analysis of early steps in toll-like receptor signalling
    Peter Ulrichts
    Department of Medical Protein Research, Ghent University VIB, Ghent, Belgium
    Methods Mol Biol 517:133-44. 2009
    ..In the subsequent protocol, we describe the use of MAPPIT to study early events in Toll-like receptor (TLR) signalling. We here demonstrate a "signalling interaction cascade" from TLR4 to IRAK-1...
  64. ncbi The RNA helicase Lgp2 inhibits TLR-independent sensing of viral replication by retinoic acid-inducible gene-I
    Simon Rothenfusser
    Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    J Immunol 175:5260-8. 2005
    ..Toll-IL-1 resistance domain containing adapters MyD88, Mal, Toll/IL-1R domain-containing adaptor inducing IFN-beta (TRIF), and TRIF-related adaptor molecule TLR3, or the E3 ubiquitin ligase, TNFR-associated factor 6...
  65. pmc Mycobacterial phosphatidylinositol mannosides negatively regulate host Toll-like receptor 4, MyD88-dependent proinflammatory cytokines, and TRIF-dependent co-stimulatory molecule expression
    Emilie Doz
    Orleans University and CNRS, Molecular Immunology and Embryology, UMR6218, France
    J Biol Chem 284:23187-96. 2009
    ..PIM also reduced the LPS-induced MyD88-independent, TIR domain-containing adaptor protein inducing interferon beta (TRIF)-mediated expression of co-stimulatory receptors. PIM inhibited LPS/TLR4-induced NFkappaB translocation...
  66. pmc Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression
    Franz G Bauernfeind
    Department of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    J Immunol 183:787-91. 2009
    ..Signals provided by NF-kappaB activators are necessary but not sufficient for NLRP3 activation, and a second stimulus such as ATP or crystal-induced damage is required for NLRP3 activation...
  67. pmc Selective expansion of the monocytic lineage directed by bacterial infection
    Natalya V Serbina
    Infectious Disease Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, Immunology Program, Sloan Kettering Institute, New York, NY 10021, USA
    J Immunol 183:1900-10. 2009
    ..Although MyD88/Trif-mediated signaling is not required for early emigration of the mature monocyte population from the bone marrow, ..
  68. pmc Lipopolysaccharide-driven Th2 cytokine production in macrophages is regulated by both MyD88 and TRAM
    Sumanta Mukherjee
    Department of Medicine, University of Toledo Medical Center, Toledo, Ohio 43614, USA
    J Biol Chem 284:29391-8. 2009
    ..Silencing of myeloid differentiation protein (MyD88) and TRIF-related adaptor molecule (TRAM), using small interfering RNA abolished IL-4 induction induced by LPS whereas ..
  69. pmc The toll-Like receptor adaptor TRIF contributes to otitis media pathogenesis and recovery
    Anke Leichtle
    Department of Surgery Otolaryngology University of California, San Diego, 9500 Gilman Avenue, La Jolla, California 92093, USA
    BMC Immunol 10:45. 2009
    ..effects; MyD88 (Myeloid differentiation primary response gene 88) inducing primarily interleukin expression and TRIF (Tir-domain-containing adaptor inducing interferon beta) mediating type I interferon (IFN) expression...
  70. pmc TRIF and IRF-3 binding to the TNF promoter results in macrophage TNF dysregulation and steatosis induced by chronic ethanol
    Xue Jun Zhao
    Department of Pediatrics, Children s Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Immunol 181:3049-56. 2008
    ..As IRF-3 is downstream from the TLR4 adaptor TIR-domain-containing adapter-inducing IFN-beta (Trif), we demonstrate that macrophages from Trif-/- mice are resistant to this dysregulation of TNF-alpha transcription ..
  71. pmc Helminth cysteine proteases inhibit TRIF-dependent activation of macrophages via degradation of TLR3
    Sheila Donnelly
    Institute for the Biotechnology of Infectious Diseases, University of Technology Sydney, Level 6, Building 4, Corner of Thomas and Harris Street, Ultimo, Sydney, New South Wales 2007, Australia
    J Biol Chem 285:3383-92. 2010
    ..The proteases specifically block the MyD88-independent TRIF-dependent signaling pathway of Toll-like receptor (TLR)4 and TLR3...
  72. doi Recipient Toll-like receptors contribute to chronic graft dysfunction by both MyD88- and TRIF-dependent signaling
    Shijun Wang
    Department of Cellular and Molecular Pathology, German Cancer Research Center, D 69120 Heidelberg, Germany
    Dis Model Mech 3:92-103. 2010
    ..In a genetic approach to define the contribution of TLR2 and TLR4, and their adaptor proteins MyD88 and TRIF [Toll/interleukin (IL)-1 receptor domain-containing adaptor-protein inducing interferon beta], to CAD, kidney ..
  73. doi TLR4 is a negative regulator in noninfectious lung inflammation
    Hang Zhao
    Pulmonary and Critical Care Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    J Immunol 184:5308-14. 2010
    ..These data provide a molecular level explanation for the function of TLR4 in LMW HA (200 kDa)-induced lung inflammation, as inhibition of the beta form of pro-IL-1 promotes an anti-inflammatory response...
  74. pmc Stimulation of Toll-like receptor 3 and 4 induces interleukin-1beta maturation by caspase-8
    Jonathan Maelfait
    Unit of Molecular Signal Transduction in Inflammation, Department for Molecular Biomedical Research, VIB, B 9052 Ghent, Belgium
    J Exp Med 205:1967-73. 2008
    ..These results implicate a novel role for caspase-8 in the production of biologically active IL-1beta in response to TLR3 and TLR4 stimulation...
  75. pmc MyD88 but not TRIF is essential for osteoclastogenesis induced by lipopolysaccharide, diacyl lipopeptide, and IL-1alpha
    Nobuaki Sato
    Dept of Biochemistry, Matsumoto Dental University, 1780 Gobara, Hiro oka, Shiojiri, Nagano 399 0781, Japan
    J Exp Med 200:601-11. 2004
    ..Toll-IL-1 receptor domain-containing adaptor inducing interferon-beta (TRIF)-mediated signals are involved in lipopolysaccharide (LPS)-induced MyD88-independent pathways...
  76. pmc Dominant role of the MyD88-dependent signaling pathway in mediating early endotoxin-induced murine ileus
    Bettina M Buchholz
    Dept of Medicine Gastroenterology Univ of Pittsburgh, Pennsylvania 15261, USA
    Am J Physiol Gastrointest Liver Physiol 299:G531-8. 2010
    ..primary response gene 88 (MyD88) and Toll-IL-1-resistance (TIR) domain-containing adaptor-inducing IFN-beta (TRIF)...
  77. doi Platelet-derived growth factor receptor regulates salivary gland morphogenesis via fibroblast growth factor expression
    Shinya Yamamoto
    Division of Oral Health, Growth and Development, Faculty of Dental Science, Kyushu University, Fukuoka 812 8582, Japan
    J Biol Chem 283:23139-49. 2008
    ..Thus, PDGF signaling is a possible mechanism involved in the interaction between epithelial and neural crest-derived mesenchyme...
  78. doi Viral inhibitory peptide of TLR4, a peptide derived from vaccinia protein A46, specifically inhibits TLR4 by directly targeting MyD88 adaptor-like and TRIF-related adaptor molecule
    Tatyana Lysakova-Devine
    Immunology Research Centre, School of Biochemistry and Immunology, Trinity College Dublin, Ireland
    J Immunol 185:4261-71. 2010
    ..directly interacted with the TLR4 adaptor proteins MyD88 adaptor-like (Mal) and TRIF-related adaptor molecule (TRAM). Viral proteins target host proteins using evolutionary optimized binding surfaces...
  79. pmc Non-hematopoietic cells contribute to protective tolerance to Aspergillus fumigatus via a TRIF pathway converging on IDO
    Antonella De Luca
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy
    Cell Mol Immunol 7:459-70. 2010
    ..occurred through a Toll-like receptor 3/Toll/IL-1 receptor domain-containing adaptor-inducing interferon (TLR3/TRIF)-dependent pathway converging on indoleamine 2,3-dioxygenase (IDO) via non-canonical nuclear factor-κB activation...
  80. pmc Murine mammary carcinoma cells and CD11c(+) dendritic cells elicit distinct responses to lipopolysaccharide and exhibit differential expression of genes required for TLR4 signaling
    Chiquita Palha De Sousa
    Department of Biology, Lafayette College, Easton, PA 18042, USA
    Cell Immunol 266:67-75. 2010
    ..A potential reason for differential responsiveness was that DC expressed greater levels of TLR4, CD14, Myd88, and TRAM. Despite the low level of TLR signaling proteins, the carcinoma were able to elicit a range of responses contingent ..
  81. pmc Helicobacter infection alters MyD88 and Trif signalling in response to intestinal ischaemia-reperfusion
    Sara M Hoffman
    Kansas State University, Division of Biology, Manhattan, KS 66506, USA
    Exp Physiol 96:104-13. 2011
    ..DAF mRNA expression in uninfected wild-type, MyD88(-/-) or TIR-domain-containing adaptor-inducing interferon-β (Trif)-deficient mice...
  82. doi Phosphatidylinositol 3-kinase activation attenuates the TLR2-mediated macrophage proinflammatory cytokine response to Francisella tularensis live vaccine strain
    Edward A Medina
    Department of Microbiology and Immunology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    J Immunol 185:7562-72. 2010
    ..This TLR2-independent inhibitory pathway may be an important mechanism by which Francisella suppresses the host's innate immune response...
  83. ncbi MyD88 functions as a negative regulator of TLR3/TRIF-induced corneal inflammation by inhibiting activation of c-Jun N-terminal kinase
    Angela C Johnson
    Department of Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Biol Chem 283:3988-96. 2008
    ..Toll-like receptors except TLR3 and a subset of TLR4 signaling events, which are mediated by the adaptor molecule TRIF. To determine the role of TRIF in host inflammatory responses, corneal epithelium of C57BL/6, TLR3(-/-), TRIF(-/-), ..
  84. ncbi The histone methyltransferase Suv39h1 increases class switch recombination specifically to IgA
    Sean P Bradley
    Immunology and Virology Program, Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Immunol 177:1179-88. 2006
    ..Taken together, our results suggest that Suv39h1 activity inhibits the activity of a sequence-specific DNA-binding protein that represses switch recombination to IgA...
  85. pmc The immunoproteasomes regulate LPS-induced TRIF/TRAM signaling pathway in murine macrophages
    Julia Reis
    Department of Basic Medical Science, School of Medicine, Shock Trauma Research Center, University of Missouri, Kansas City, MO 64108, USA
    Cell Biochem Biophys 60:119-26. 2011
    ..The recent studies suggest that the TRIF/TRAM pathway is defective in LMP knockouts which may explain why iNOS/NO are not robustly induced in LPS-treated ..
  86. doi Recognition of yeast nucleic acids triggers a host-protective type I interferon response
    Carmelo Biondo
    The Elie Metchnikoff Department, University of Messina, Messina, Italy
    Eur J Immunol 41:1969-79. 2011
    ..These data suggest that recognition of yeast nucleic acids by TLR7 and TLR9 triggers a host-protective IFN-α/β response...
  87. pmc Salmonella-induced SipB-independent cell death requires Toll-like receptor-4 signalling via the adapter proteins Tram and Trif
    Pamela Cook
    Centre for Veterinary Science, Department of Veterinary Medicine, University of Cambridge, Cambridge, UK
    Immunology 122:222-9. 2007
    ..Gram-negative bacteria and is recognized by Toll-like receptor 4, signalling via the adapter proteins Mal, MyD88, Tram and Trif. Here we show that S...
  88. pmc TRIF is a critical negative regulator of TLR agonist mediated activation of dendritic cells in vivo
    Sergey S Seregin
    Department of Microbiology and Molecular Genetics, College of Osteopathic Medicine, Michigan State University, East Lansing, Michigan, United States of America
    PLoS ONE 6:e22064. 2011
    ..Surprisingly, we also found that the TRIF adaptor protein acts as a potent negative regulator of TLR agonist-triggered immune responses...

Research Grants3

  1. Donor Antigen-Induced Peripheral Tolerance
    Dianne McKay; Fiscal Year: 2006
    ..We believe that intracellular signaling alterations that lead to alloantigen-induced tolerance may provide novel targets for a new generation of tolerizing immunosuppressive agents. ..
  2. Innate immune responses in lymphatic filariasis
    AMY HISE; Fiscal Year: 2007
    ..abstract_text> ..
  3. B1B lymphocytes generate T cell-independent memory
    KISHORE ALUGUPALLI; Fiscal Year: 2009
    ..Understanding the basis for the longevity of the Tl protective responses conferred by B1b cells will provide novel approaches to generate effective vaccines against pathogens expressing Tl antigens. ..