Ticam1

Summary

Gene Symbol: Ticam1
Description: toll-like receptor adaptor molecule 1
Alias: AW046014, AW547018, TICAM-1, TRIF, TIR domain-containing adapter molecule 1, TIR domain-containing adapter protein inducing IFN-beta, TIR domain-containing adaptor inducing interferon-beta, toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta
Species: mouse

Top Publications

  1. ncbi Identification of a TLR4- and TRIF-dependent activation program of dendritic cells
    Heike Weighardt
    Department of Surgery, Technical University Munich, Munich, Germany
    Eur J Immunol 34:558-64. 2004
  2. pmc Caspase-1 independent IL-1beta production is critical for host resistance to mycobacterium tuberculosis and does not require TLR signaling in vivo
    Katrin D Mayer-Barber
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 184:3326-30. 2010
  3. ncbi Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses
    Hiroki Kato
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan
    Nature 441:101-5. 2006
  4. pmc Toll-like receptors activate programmed necrosis in macrophages through a receptor-interacting kinase-3-mediated pathway
    Sudan He
    Cyrus Tang Hematology Center, Jiangsu Institute of Hematology, First Affiliated Hospital, Soochow University, Suzhou 215123, China
    Proc Natl Acad Sci U S A 108:20054-9. 2011
  5. pmc MyD88 and Trif target Beclin 1 to trigger autophagy in macrophages
    Chong Shan Shi
    B Cell Molecular Immunology Section, Laboratory of Immunoregulation, NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 283:33175-82. 2008
  6. pmc Slc15a4, AP-3, and Hermansky-Pudlak syndrome proteins are required for Toll-like receptor signaling in plasmacytoid dendritic cells
    Amanda L Blasius
    Department of Genetics, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 107:19973-8. 2010
  7. doi Phosphatidylinositol 3-kinase activation attenuates the TLR2-mediated macrophage proinflammatory cytokine response to Francisella tularensis live vaccine strain
    Edward A Medina
    Department of Microbiology and Immunology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    J Immunol 185:7562-72. 2010
  8. pmc Interferon response factors 3 and 7 protect against Chikungunya virus hemorrhagic fever and shock
    Penny A Rudd
    Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    J Virol 86:9888-98. 2012
  9. pmc Dynamic regulation of pro- and anti-inflammatory cytokines by MAPK phosphatase 1 (MKP-1) in innate immune responses
    Hongbo Chi
    Section of Immunobiology, Department of Pharmacology, and Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 103:2274-9. 2006
  10. pmc A novel IFN regulatory factor 3-dependent pathway activated by trypanosomes triggers IFN-beta in macrophages and fibroblasts
    Anne Danielle C Chessler
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    J Immunol 181:7917-24. 2008

Research Grants

  1. PAIN EVOKED RELEASE OF AMINO ACIDS AND PROSTANOIDS
    Tony Yaksh; Fiscal Year: 2005
  2. SIGNIFICANCE OF IMMUNOLOGICAL SEQUESTRATION IN THE EYE
    DALE SANNES GREGERSON; Fiscal Year: 2010
  3. Local Retinal Antigen Presentation
    DALE SANNES GREGERSON; Fiscal Year: 2010
  4. PATHOGENESIS OF MURINE SYSTEMIC LUPUS ERYTHEMATOSUS
    DWIGHT KONO; Fiscal Year: 2009
  5. Pain Mechanisms and the Development of Analgesics
    Tony Yaksh; Fiscal Year: 2006
  6. NEUROBIOLOGY OF PAIN
    Tony Yaksh; Fiscal Year: 2005
  7. Spinal Galanin and its Receptors in Pain Processing
    Tony Yaksh; Fiscal Year: 2005
  8. TOLL RECEPTORS AND CONTROL OF MAMMALIAN IMMUNITY
    Ruslan Medzhitov; Fiscal Year: 2005
  9. CORNEAL ENDOTHELIAL CELL IMMUNOREGULATORY FACTORS
    DALE GREGERSON; Fiscal Year: 2003
  10. Donor Antigen-Induced Peripheral Tolerance
    Dianne McKay; Fiscal Year: 2006

Scientific Experts

Detail Information

Publications144 found, 100 shown here

  1. ncbi Identification of a TLR4- and TRIF-dependent activation program of dendritic cells
    Heike Weighardt
    Department of Surgery, Technical University Munich, Munich, Germany
    Eur J Immunol 34:558-64. 2004
    ..pathway, TLR4 engages the adaptor protein Toll/IL-1 receptor (TIR)-domain-containing adaptor inducing IFN-beta (TRIF), leading to interferon regulatory factor 3 (IRF-3) activation and type I interferon production...
  2. pmc Caspase-1 independent IL-1beta production is critical for host resistance to mycobacterium tuberculosis and does not require TLR signaling in vivo
    Katrin D Mayer-Barber
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 184:3326-30. 2010
    ..tuberculosis infection in MyD88, TRIF/MyD88, IL-1R1, and IL-1beta-deficient mice...
  3. ncbi Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses
    Hiroki Kato
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan
    Nature 441:101-5. 2006
    ..Together, our data show that RIG-I and MDA5 distinguish different RNA viruses and are critical for host antiviral responses...
  4. pmc Toll-like receptors activate programmed necrosis in macrophages through a receptor-interacting kinase-3-mediated pathway
    Sudan He
    Cyrus Tang Hematology Center, Jiangsu Institute of Hematology, First Affiliated Hospital, Soochow University, Suzhou 215123, China
    Proc Natl Acad Sci U S A 108:20054-9. 2011
    ..An adaptor protein, Toll/IL-1 receptor domain-containing adapter inducing IFN-β (TRIF/TICAM-1), which is dispensable for TNF-α-induced necrosis, forms a complex with RIP3 upon TLR3/TLR4 activation and ..
  5. pmc MyD88 and Trif target Beclin 1 to trigger autophagy in macrophages
    Chong Shan Shi
    B Cell Molecular Immunology Section, Laboratory of Immunoregulation, NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 283:33175-82. 2008
    ..that not only TLR4, but also other TLR family members induce autophagy in macrophages, which is inhibited by MyD88, Trif, or Beclin 1 shRNA expression...
  6. pmc Slc15a4, AP-3, and Hermansky-Pudlak syndrome proteins are required for Toll-like receptor signaling in plasmacytoid dendritic cells
    Amanda L Blasius
    Department of Genetics, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 107:19973-8. 2010
    ..These proteins are not necessary for TLR7 or TLR9 signaling in conventional DCs and thus comprise a membrane trafficking pathway uniquely required for endosomal TLR signaling in pDCs...
  7. doi Phosphatidylinositol 3-kinase activation attenuates the TLR2-mediated macrophage proinflammatory cytokine response to Francisella tularensis live vaccine strain
    Edward A Medina
    Department of Microbiology and Immunology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    J Immunol 185:7562-72. 2010
    ..This TLR2-independent inhibitory pathway may be an important mechanism by which Francisella suppresses the host's innate immune response...
  8. pmc Interferon response factors 3 and 7 protect against Chikungunya virus hemorrhagic fever and shock
    Penny A Rudd
    Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    J Virol 86:9888-98. 2012
    ..IPS-1- and TRIF-dependent pathways were primarily responsible for IFN-α/β induction, with IRF7 being upregulated >100-fold in ..
  9. pmc Dynamic regulation of pro- and anti-inflammatory cytokines by MAPK phosphatase 1 (MKP-1) in innate immune responses
    Hongbo Chi
    Section of Immunobiology, Department of Pharmacology, and Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 103:2274-9. 2006
    ..mediated by both myeloid differentiation factor 88 (MyD88) and TIR domain-containing adaptor inducing IFN-beta (TRIF)...
  10. pmc A novel IFN regulatory factor 3-dependent pathway activated by trypanosomes triggers IFN-beta in macrophages and fibroblasts
    Anne Danielle C Chessler
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    J Immunol 181:7917-24. 2008
    ..cruzi-mediated expression of IFN-beta. The TLR adaptors MyD88 and TRIF, as well as TLR4 and TLR3, were found to be dispensable, demonstrating that T...
  11. pmc The major component in schistosome eggs responsible for conditioning dendritic cells for Th2 polarization is a T2 ribonuclease (omega-1)
    Svenja Steinfelder
    Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 206:1681-90. 2009
    ..Th2-promoting activity of omega-1 was found to be sensitive to ribonuclease inhibition and did not require MyD88/TRIF signaling in DCs...
  12. ncbi Cell type-specific involvement of RIG-I in antiviral response
    Hiroki Kato
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Osaka 565 0871, Japan
    Immunity 23:19-28. 2005
    ..In contrast, plasmacytoid DCs, which produce large amounts of IFN-alpha, use the TLR system rather than RIG-I for viral detection. Taken together, RIG-I and the TLR system exert antiviral responses in a cell type-specific manner...
  13. ncbi Natural killer T cells recognize diacylglycerol antigens from pathogenic bacteria
    Yuki Kinjo
    Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology, La Jolla, California 92037, USA
    Nat Immunol 7:978-86. 2006
    ....
  14. pmc TRIF and IRF-3 binding to the TNF promoter results in macrophage TNF dysregulation and steatosis induced by chronic ethanol
    Xue Jun Zhao
    Department of Pediatrics, Children s Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Immunol 181:3049-56. 2008
    ..As IRF-3 is downstream from the TLR4 adaptor TIR-domain-containing adapter-inducing IFN-beta (Trif), we demonstrate that macrophages from Trif-/- mice are resistant to this dysregulation of TNF-alpha transcription ..
  15. pmc Signalling mechanisms for Toll-like receptor-activated neutrophil exocytosis: key roles for interleukin-1-receptor-associated kinase-4 and phosphatidylinositol 3-kinase but not Toll/IL-1 receptor (TIR) domain-containing adaptor inducing IFN-beta (TRIF)
    Agnieszka A Brzezinska
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, USA
    Immunology 127:386-97. 2009
    ..kinase (IRAK)-4- and Toll/IL-1 receptor (TIR) domain-containing adaptor inducing IFN-beta (TRIF)-deficient mice, we dissected the signalling pathways that control exocytosis...
  16. doi IFN regulatory factor 3 contributes to the host response during Pseudomonas aeruginosa lung infection in mice
    Svetlana O Carrigan
    Department of Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia, Canada
    J Immunol 185:3602-9. 2010
    ..aeruginosa infection. Thus, IRF3 is an integral component in the host defense against P. aeruginosa lung infection...
  17. pmc The toll-like receptor 3-mediated antiviral response is important for protection against poliovirus infection in poliovirus receptor transgenic mice
    Yuko Abe
    Neurovirology Project, Tokyo Metropolitan Institute of Medical Science, 2 1 6 Kamikitazawa, Setagaya Ku, Tokyo 156 8506, Japan
    J Virol 86:185-94. 2012
    ..nonneural tissues and mortality rates were both markedly higher in TIR domain-containing adaptor-inducing IFN-β (TRIF)-deficient and TLR3-deficient mice than in wild-type mice...
  18. pmc Toll-like receptor 3 signaling converts tumor-supporting myeloid cells to tumoricidal effectors
    Hiroaki Shime
    Department of Microbiology and Immunology, Graduate School of Medicine, Hokkaido University, Kita ku, Sapporo 060 8638, Japan
    Proc Natl Acad Sci U S A 109:2066-71. 2012
    ....
  19. pmc Bacterial RNA mediates activation of caspase-1 and IL-1β release independently of TLRs 3, 7, 9 and TRIF but is dependent on UNC93B
    Tatjana Eigenbrod
    Department of Infectious Diseases, Medical Microbiology and Hygiene, University of Heidelberg, 69120 Heidelberg, Germany
    J Immunol 189:328-36. 2012
    ..and IL-1β production by transfected bacterial RNA were absent in MyD88-deficient cells but independent of TRIF. Thus, our data indicate the presence of a yet unidentified intracellular nucleic acid receptor involved in ..
  20. pmc Distinct roles for Dectin-1 and TLR4 in the pathogenesis of Aspergillus fumigatus keratitis
    Sixto M Leal
    Department of Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, Ohio, United States of America
    PLoS Pathog 6:e1000976. 2010
    ..We also found that TRIF(-/-) and TIRAP(-/-) mice exhibited no fungal-killing defects, but that MyD88(-/-) and IL-1R1(-/-) mice were unable ..
  21. doi Identification of oxidative stress and Toll-like receptor 4 signaling as a key pathway of acute lung injury
    Yumiko Imai
    IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Dr Bohrgasse 3, A 1030 Vienna, Austria
    Cell 133:235-49. 2008
    ..We show that TLR4-TRIF-TRAF6 signaling is a key disease pathway that controls the severity of ALI...
  22. ncbi Polyinosinic acid is a ligand for toll-like receptor 3
    Stuart Marshall-Clarke
    Department of Human Anatomy and Cell Biology, The University of Liverpool, Liverpool L69 3GE, United Kingdom
    J Biol Chem 282:24759-66. 2007
    ..responses are dependent on the expression of both TLR3 and the adaptor molecule, Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF). We therefore conclude that TLR3 is able to sense both single-stranded RNA and dsRNA.
  23. doi TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines
    Ken J Ishii
    Exploratory Research for Advanced Technology ERATO, Japan Science and Technology Agency JST
    Nature 451:725-9. 2008
    ..These data suggest that TBK1 is a key signalling molecule for DNA-vaccine-induced immunogenicity, by differentially controlling DNA-activated innate immune signalling through haematopoietic and non-haematopoietic cells...
  24. pmc TANK-binding kinase-1 plays an important role during in vitro and in vivo type I IFN responses to DNA virus infections
    Andrea K Miyahira
    Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, CA 90095, USA
    J Immunol 182:2248-57. 2009
    ..Finally, we demonstrate the requirement for the TBK1-IFN regulatory factor-3 pathway in host defense against a DNA virus infection in vivo...
  25. doi Critical role of the IFN-stimulated gene factor 3 complex in TLR-mediated IL-27p28 gene expression revealing a two-step activation process
    Céline Molle
    Institute for Medical Immunology, Universite Libre de Bruxelles, Brussels, Belgium
    J Immunol 184:1784-92. 2010
    ..These results highlight the complex molecular interplay between TLRs and type I IFNs for the control of IL-27 synthesis...
  26. pmc The Lyme disease spirochete Borrelia burgdorferi utilizes multiple ligands, including RNA, for interferon regulatory factor 3-dependent induction of type I interferon-responsive genes
    Jennifer C Miller
    Department of Pathology, University of Utah, Salt Lake City, Utah 84112, USA
    Infect Immun 78:3144-53. 2010
    ..burgdorferi-stimulated BMDMs occurs independently of the adapter TRIF and of the cytoplasmic sensor NOD2. In contrast, B...
  27. ncbi Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-kappa B and IFN-regulatory factor-3, in the Toll-like re
    Shintaro Sato
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Suita, Japan
    J Immunol 171:4304-10. 2003
    ..reported a new Toll/IL-1R (TIR)-containing molecule, named TIR domain-containing adaptor inducing IFN-beta (TRIF)...
  28. ncbi ASC is essential for LPS-induced activation of procaspase-1 independently of TLR-associated signal adaptor molecules
    Masatatsu Yamamoto
    Department of Molecular Oncology Division of Molecular and Cellular Biology Institute on Ageing and Adaptation, Shinshu University Graduate School of Medicine, 3 1 1 Asahi, Matsumoto 390 8621, Japan
    Genes Cells 9:1055-67. 2004
    ..adaptor molecule, myeloid differentiation factor 88 (MyD88) and/or TIR domain-containing adaptor inducing-IFN-beta (Trif), to induce various pro-inflammatory cytokines for microbial eradication...
  29. ncbi Efficient T cell activation via a Toll-Interleukin 1 Receptor-independent pathway
    Edith Janssen
    Department of Developmental Immunology, La Jolla Institute for Allergy and Immunology, San Diego, California 92121, USA
    Immunity 24:787-99. 2006
    ....
  30. pmc MyD88-dependent IL-1 receptor signaling is essential for gouty inflammation stimulated by monosodium urate crystals
    Chun Jen Chen
    Department of Pathology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Clin Invest 116:2262-71. 2006
    ..In contrast, other TIR adaptor molecules, TIRAP/Mal, TRIF, and TRAM, are not required for this process...
  31. ncbi Nonredundant roles of TIRAP and MyD88 in airway response to endotoxin, independent of TRIF, IL-1 and IL-18 pathways
    Dieudonnée Togbe
    Molecular Immunology and Embryology, CNRS UMR6218, Transgenose Institute, Orleans, France
    Lab Invest 86:1126-35. 2006
    ..However, the relative roles of the TLR4 adaptor proteins TIRAP and TRIF and of the MyD88-dependent IL-1 and IL-18 receptor pathways in this response are unclear...
  32. ncbi Pannexin-1-mediated recognition of bacterial molecules activates the cryopyrin inflammasome independent of Toll-like receptor signaling
    Thirumala Devi Kanneganti
    Department of Pathology, Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Immunity 26:433-43. 2007
    ..These results provide evidence for cytosolic delivery and sensing of bacterial molecules as a unifying model for caspase-1 activation and position pannexin-1 as a mechanistic link between bacterial stimuli and the cryopyrin inflammasome...
  33. doi Stimulation of dendritic cells via the dectin-1/Syk pathway allows priming of cytotoxic T-cell responses
    Salome Leibundgut-Landmann
    Immunobiology Laboratory, Cancer Research UK, London Research Institute, Lincoln s Inn Fields Laboratories, London, United Kingdom
    Blood 112:4971-80. 2008
    ..These data highlight the ability of non-TLR receptors to bridge innate and adaptive immunity and suggest that dectin-1 agonists may constitute useful adjuvants for immunotherapy and vaccination...
  34. doi Bacterial endotoxin induces the release of high mobility group box 1 via the IFN-beta signaling pathway
    Ju Hyun Kim
    Department of Pathology, Hallym University College of Medicine, Chuncheon, Korea
    J Immunol 182:2458-66. 2009
    ..Our results suggest that HMGB1 release in sepsis is dependent on the IFN-beta signaling axis; thus, therapeutic agents that selectively inhibit IFN-beta signaling could be beneficial in the treatment of sepsis...
  35. pmc Virus binding to a plasma membrane receptor triggers interleukin-1 alpha-mediated proinflammatory macrophage response in vivo
    Nelson C Di Paolo
    Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, WA 98195, USA
    Immunity 31:110-21. 2009
    ..Thus, these data identify IL-1 alpha-IL-1RI as a key pathway allowing for the activation of proinflammatory responses to the virus, independently of its genomic nucleic acid recognition...
  36. ncbi TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-beta induction
    Hiroyuki Oshiumi
    Department of Immunology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Higashinari ku, Japan
    Nat Immunol 4:161-7. 2003
    ..Thus, dsRNA-TLR3-dependent production of IFN-beta is mediated mainly by TICAM-1. This TICAM-1-dependent pathway may have a role in other TLR-IFN-beta pathways, which form part of the MyD88-independent cellular immune response...
  37. ncbi Identification of Lps2 as a key transducer of MyD88-independent TIR signalling
    K Hoebe
    Department of Immunology, IMM 31, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Nature 424:743-8. 2003
    ..Lps2 mutation: a distal frameshift error in a Toll/interleukin-1 receptor/resistance (TIR) adaptor protein known as Trif or Ticam-1...
  38. ncbi RIP1 is an essential mediator of Toll-like receptor 3-induced NF-kappa B activation
    Etienne Meylan
    Department of Biochemistry, University of Lausanne, BIL Biomedical Research Center, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Nat Immunol 5:503-7. 2004
    ..innate immune responses through Toll-interleukin 1 receptor (TIR) domain-containing adaptors such as MyD88 and Trif. Analysis of Trif-deficient mice has shown that TLR3-dependent activation of the transcription factor NF-kappa B by ..
  39. ncbi Signaling of apoptosis through TLRs critically involves toll/IL-1 receptor domain-containing adapter inducing IFN-beta, but not MyD88, in bacteria-infected murine macrophages
    Klaus Ruckdeschel
    Max von Pettenkofer Institute for Hygiene and Medical Microbiology, Munich, Germany
    J Immunol 173:3320-8. 2004
    ..Experiments using murine macrophages defective for MyD88 or Toll/IL-1R domain-containing adapter inducing IFN-beta (TRIF) revealed that deficiency of TRIF, but not of MyD88, provides protection against Yersinia-mediated cell death...
  40. ncbi The MyD88-dependent, but not the MyD88-independent, pathway of TLR4 signaling is important in clearing nontypeable haemophilus influenzae from the mouse lung
    Catharina W Wieland
    Laboratory of Experimental Internal Medicine, University of Amsterdam, Amsterdam, The Netherlands
    J Immunol 175:6042-9. 2005
    ..on the common TLR adaptor MyD88 and one that is mediated by Toll/IL-1R domain-containing adaptor-inducing IFN-beta (TRIF)...
  41. ncbi Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6
    Hans Hacker
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA
    Nature 439:204-7. 2006
    ..TRAF3 is also recruited to the adaptor TRIF (Toll/IL-1 receptor domain-containing adaptor-inducing IFN-beta) and is required for marshalling the protein kinase ..
  42. ncbi Recognition of cytosolic DNA activates an IRF3-dependent innate immune response
    Daniel B Stetson
    Howard Hughes Medical Institute, Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Immunity 24:93-103. 2006
    ..These findings define an innate immune response to DNA linked to type I interferon production...
  43. ncbi Innate immune activation and CD4+ T cell priming during respiratory fungal infection
    Amariliz Rivera
    Infectious Diseases Service, Immunology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 9, New York, New York 10021, USA
    Immunity 25:665-75. 2006
    ....
  44. ncbi TLR-dependent induction of IFN-beta mediates host defense against Trypanosoma cruzi
    Ritsuko Koga
    Department of Molecular Genetics, Medical Institute of Bioregulation, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Immunol 177:7059-66. 2006
    ..cruzi by focusing on innate immunity. Macrophages and dendritic cells (DCs) from MyD88(-/-)TRIF(-/-) mice, in which TLR-dependent activation of innate immunity was abolished, were defective in the clearance of T...
  45. pmc Antitumor NK activation induced by the Toll-like receptor 3-TICAM-1 (TRIF) pathway in myeloid dendritic cells
    Takashi Akazawa
    Department of Immunology, Osaka Medical Center for Cancer, Nakamichi 1 3 2, Higashinari ku, Osaka 537 8511, Japan
    Proc Natl Acad Sci U S A 104:252-7. 2007
    ..Here, we show that the TLR adaptor TICAM-1 (TRIF) participates in mDC-derived antitumor NK activation. In a syngeneic mouse tumor implant model (C57BL/6 vs...
  46. ncbi Vesicular stomatitis virus glycoprotein G activates a specific antiviral Toll-like receptor 4-dependent pathway
    Philippe Georgel
    Department of Immunology, The Scripps Research Institute, 10550 N Torrey Pines Rd, La Jolla, CA 92037, USA
    Virology 362:304-13. 2007
    ..adapter TRAM has predominant importance, absent any need for MyD88 or Mal, and with only a partial requirement for TRIF. Downstream of TRAM, IRF7 activation leads to a type I IFN response...
  47. ncbi MyD88-dependent activation of B220-CD11b+LY-6C+ dendritic cells during Brucella melitensis infection
    Richard Copin
    Unité de Recherche en Biologie Moléculaire, Laboratoire d Immunologie et de Microbiologie, Faculté Universitaire Notre Dame de la Paix, Namur, Belgium
    J Immunol 178:5182-91. 2007
    ..Taken together, our results provide new insight into how immune responses fight Brucella infection...
  48. pmc MyD88-dependent expansion of an immature GR-1(+)CD11b(+) population induces T cell suppression and Th2 polarization in sepsis
    Matthew J Delano
    Department of Surgery, University of Florida College of Medicine, Gainesville, FL 32610, USA
    J Exp Med 204:1463-74. 2007
    ..GR-1(+)CD11b(+) cells contribute to sepsis-induced T cell suppression and preferential Th2 polarization...
  49. ncbi Role for MyD88-independent, TRIF pathway in lipid A/TLR4-induced endotoxin tolerance
    Subhra K Biswas
    Singapore Immunology Network, Biomedical Sciences Institutes, Agency for Science, Technology and Research, Immunos
    J Immunol 179:4083-92. 2007
    ..We investigated the role of the TRIF/IFN-beta pathway in TLR4-induced endotoxin tolerance...
  50. ncbi MyD88 functions as a negative regulator of TLR3/TRIF-induced corneal inflammation by inhibiting activation of c-Jun N-terminal kinase
    Angela C Johnson
    Department of Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Biol Chem 283:3988-96. 2008
    ..Toll-like receptors except TLR3 and a subset of TLR4 signaling events, which are mediated by the adaptor molecule TRIF. To determine the role of TRIF in host inflammatory responses, corneal epithelium of C57BL/6, TLR3(-/-), TRIF(-/-), ..
  51. ncbi Cutting edge: cooperation of IPS-1- and TRIF-dependent pathways in poly IC-enhanced antibody production and cytotoxic T cell responses
    Himanshu Kumar
    Laboratory of Host Defense, WPI Immunology Frontier Research Center, Osaka University, Osaka, Japan
    J Immunol 180:683-7. 2008
    ..gene 5 (Mda5), which signal through the adaptors Toll/IL-1R domain-containing adaptor inducing IFN-beta (TRIF) and IFN-beta promoter stimulator-1 (IPS-1), respectively...
  52. ncbi Neutrophil chemokines KC and macrophage-inflammatory protein-2 are newly synthesized by tissue macrophages using distinct TLR signaling pathways
    Katia De Filippo
    Leukocyte Adhesion Laboratory, Cancer Research United Kingdom, London Research Institute, London, United Kingdom
    J Immunol 180:4308-15. 2008
    ..The major and alternative TLR signaling pathways are characterized by the adaptor proteins MyD88 or TRIF, respectively. KC and MIP-2 are both produced by signaling through MyD88...
  53. pmc The type I IFN induction pathway constrains Th17-mediated autoimmune inflammation in mice
    Beichu Guo
    Department of Microbiology, Immunology, and Molecular Genetics, 8 240 Factor Building, University of California, 10833 Le Conte Avenue, Los Angeles, California 90095, USA
    J Clin Invest 118:1680-90. 2008
    ..of autoimmune disease is constrained by Toll-IL-1 receptor domain-containing adaptor inducing IFN-beta-dependent (TRIF-dependent) type I IFN production and its downstream signaling pathway...
  54. pmc A critical link between Toll-like receptor 3 and type II interferon signaling pathways in antiviral innate immunity
    Hideo Negishi
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Proc Natl Acad Sci U S A 105:20446-51. 2008
    ..Taken together, our results indicate a critical cooperation of the RIG-I/MDA5-type I IFN and the TLR3-type II IFN signaling axes for efficient innate antiviral immune responses...
  55. doi TLR2 and TLR4 signaling shapes specific antibody responses to Salmonella typhi antigens
    Luisa Cervantes-Barragan
    Medical Research Unit on Immunochemistry, Specialties Hospital of the National Medical Centre Siglo XXI, Mexican Institute for Social Security, Mexico City, Mexico
    Eur J Immunol 39:126-35. 2009
    ..Taken together, S. typhi porins represent not only a suitable B-cell antigen for vaccination, but exhibit potent TLR-dependent stimulatory functions on B cells and DC, which help to further enhance and shape the antibody response...
  56. pmc Campylobacter jejuni-induced activation of dendritic cells involves cooperative signaling through Toll-like receptor 4 (TLR4)-MyD88 and TLR4-TRIF axes
    Vijay A K Rathinam
    Comparative Enteric Diseases Laboratory, National Food Safety and Toxicology Center, Michigan State University, East Lansing, MI 48824, USA
    Infect Immun 77:2499-507. 2009
    ..88 (MyD88) and/or Toll-interleukin 1 (IL-1) receptor domain-containing adaptor-inducing beta interferon (IFN-beta) (TRIF) is critical in inducing immunity against pathogens...
  57. pmc Lipopolysaccharide potentiates effector T cell accumulation into nonlymphoid tissues through TRIF
    Jeremy P McAleer
    Department of Immunology, University of Connecticut Health Center, Farmington, Connecticut 06030, USA
    J Immunol 182:5322-30. 2009
    ..survival and Th1 differentiation by stimulating MyD88 and Toll/IL-1R domain-containing adaptor-inducing IFN-beta (TRIF) signaling pathways...
  58. doi Poly I:C-induced activation of NK cells by CD8 alpha+ dendritic cells via the IPS-1 and TRIF-dependent pathways
    Tohru Miyake
    Laboratory of Host Defense
    J Immunol 183:2522-8. 2009
    ..adaptor molecules, IFN-promoter stimulator-1 (IPS-1) and Toll/IL-1R domain-containing adaptor inducing IFN-beta (TRIF), respectively. However, it remains unclear how NK cells are activated by poly I:C in vivo...
  59. pmc Innate and adaptive immunity cooperate flexibly to maintain host-microbiota mutualism
    Emma Slack
    Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, ON L8S 4L8, Canada
    Science 325:617-20. 2009
    ..Spontaneous hyper-activation of adaptive immunity against the intestinal microbiota, secondary to innate immune deficiency, may clarify the underlying mechanisms of inflammatory diseases where immune dysfunction is implicated...
  60. pmc Caspase-8 deficiency in epidermal keratinocytes triggers an inflammatory skin disease
    Andrew Kovalenko
    Department of Biological Chemistry, The Weizmann Institute of Science, Rehovot 76100, Israel
    J Exp Med 206:2161-77. 2009
    ..depend on TNF, IL-1, dermal macrophage function, or expression of the toll-like receptor adapter proteins MyD88 or TRIF. Both interferon regulatory factor (IRF) 3 and TANK-binding kinase were constitutively phosphorylated in the ..
  61. doi Induction of an IL7-R(+)c-Kit(hi) myelolymphoid progenitor critically dependent on IFN-gamma signaling during acute malaria
    Nikolai N Belyaev
    Division of Molecular Immunology, Medical Research Council National Institute for Medical Research, London, UK
    Nat Immunol 11:477-85. 2010
    ..Thus, IFN-gamma is a key modulator of hematopoiesis and innate and adaptive immunity during acute malaria infection...
  62. pmc IFI16 is an innate immune sensor for intracellular DNA
    Leonie Unterholzner
    School of Biochemistry and Immunology, Trinity College Dublin, Dublin, Ireland
    Nat Immunol 11:997-1004. 2010
    ..IFI16 (p204) is the first PYHIN protein to our knowledge shown to be involved in IFN-β induction. Thus, the PYHIN proteins IFI16 and AIM2 form a new family of innate DNA sensors we call 'AIM2-like receptors' (ALRs)...
  63. doi TRIF is a critical survival factor in viral cardiomyopathy
    Alexander Riad
    Department of Cardiology and Pulmology, University of Griefswald, 17475 Greifswald, Germany
    J Immunol 186:2561-70. 2011
    b>TRIF is a member of the innate immune system known to be involved in viral recognition and type I IFN activation...
  64. doi Absence of TRIF signaling in lipopolysaccharide-stimulated murine mast cells
    Simone Keck
    Max Planck Institute of Immunobiology and Epigenetics, D 79108 Freiburg, Germany
    J Immunol 186:5478-88. 2011
    In macrophages, two signaling pathways, dependent on MyD88 or TIR domain-containing adaptor-inducing IFN-β (TRIF) signaling, emanate from the LPS receptor TLR4/MD-2...
  65. pmc Myocardial ischemia activates an injurious innate immune signaling via cardiac heat shock protein 60 and Toll-like receptor 4
    Yan Li
    Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Biol Chem 286:31308-19. 2011
    ..artery occlusion induced a rapid myocardial IRAK-1 activation within 30 min in wild-type (WT), TLR2(-/-), or Trif(-/-) mice, but not in TLR4(def) or MyD88(-/-) mice...
  66. doi Evidence for a gender-specific protective role of innate immune receptors in a model of perinatal brain injury
    Pedro M Pimentel-Coelho
    Neuroscience Laboratory, Centre Hospitalier Universitaire de Québec Research Center and Department of Molecular Medicine, Faculty of Medicine, Laval University, Quebec, Canada
    J Neurosci 33:11556-72. 2013
    ..in the TLR adaptor proteins Toll/interleukin-1 receptor-domain-containing adaptor protein inducing interferon β (TRIF) or myeloid differentiation factor-88 (MyD88) and CX3CR1 knock-out (KO) mice were subjected to hypoxia-ischemia at ..
  67. pmc Toll-like receptor-3 activation increases the vulnerability of the neonatal brain to hypoxia-ischemia
    Linnea Stridh
    Department of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, S 40530 Gothenburg, Sweden
    J Neurosci 33:12041-51. 2013
    ..TLR-3 pathway because mice deficient in the TLR-3 adaptor protein Toll/IL-1R domain-containing adaptor molecule-1 (TRIF) did not develop larger brain damage...
  68. ncbi Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway
    Masahiro Yamamoto
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamada oka, Suita Osaka 565 0871, Japan
    Science 301:640-3. 2003
    ..Here we disrupted the gene encoding a Toll/IL-1 receptor (TIR) domain-containing adaptor, TRIF. TRIF-deficient mice were defective in both TLR3- and TLR4-mediated expression of IFN-beta and activation of IRF-3...
  69. pmc LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF
    Katherine A Fitzgerald
    Division of Infectious Disease and Immunology, Department of Medicine, The University of Massachusetts Medical School, Worcester, MA 01605, USA
    J Exp Med 198:1043-55. 2003
    Toll-IL-1-resistance (TIR) domain-containing adaptor-inducing IFN-beta (TRIF)-related adaptor molecule (TRAM) is the fourth TIR domain-containing adaptor protein to be described that participates in Toll receptor signaling...
  70. ncbi TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway
    Masahiro Yamamoto
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamada oka, Suita Osaka 565 0871, Japan
    Nat Immunol 4:1144-50. 2003
    ..pathways mediated by Toll-interleukin 1 receptor (TIR) domain-containing adaptors such as MyD88, TIRAP and TRIF. MyD88 is a common adaptor that is essential for proinflammatory cytokine production, whereas TRIF mediates the ..
  71. ncbi Upregulation of costimulatory molecules induced by lipopolysaccharide and double-stranded RNA occurs by Trif-dependent and Trif-independent pathways
    Kasper Hoebe
    The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Nat Immunol 4:1223-9. 2003
    ..b>Trif, an adapter protein that transduces signals from Toll-like receptor 4 (TLR4) and TLR3, permits the induction of ..
  72. ncbi TLR4 and Toll-IL-1 receptor domain-containing adapter-inducing IFN-beta, but not MyD88, regulate Escherichia coli-induced dendritic cell maturation and apoptosis in vivo
    Carl De Trez
    Laboratory of Animal Physiology, Institut de Biologie et de Médecine Moléculaire, Universite Libre de Bruxelles, Gosselies, Belgium
    J Immunol 175:839-46. 2005
    ..this model, DC maturation is impaired in TLR2(-/-), TLR4(-/-) and TIR domain-containing adapter-inducing IFN-beta (TRIF)(-/-) mice. In contrast, DC apoptosis is reduced only in TLR4(-/-) and TRIF(-/-) mice...
  73. ncbi A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA
    Ken J Ishii
    Exploratory Research for Advanced Technology, Japan Science and Technology Agency, Research Institute for Microbial Diseases, Osaka University, Osaka 565 0871, Japan
    Nat Immunol 7:40-8. 2006
    ..These results suggest that both TBK1 and IKKi are required for innate immune activation by B-DNA, which might be important in antiviral innate immunity and other DNA-associated immune disorders...
  74. pmc Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus
    Leonid Gitlin
    Division of Infectious Diseases, Department of Medicine, Washington University School of Medicine, Campus Box 8118, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 103:8459-64. 2006
    ..Moreover, mda-5-/- mice exhibited a selectively impaired antiviral response to encephalomyocarditis picornavirus, indicating functional specialization of mda-5 in vivo...
  75. pmc Adjuvant-enhanced antibody responses in the absence of toll-like receptor signaling
    Amanda L Gavin
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037 USA
    Science 314:1936-8. 2006
    ..This may have important implications in the use and development of vaccine adjuvants...
  76. ncbi A role of Toll-IL-1 receptor domain-containing adaptor-inducing IFN-beta in the host response to Pseudomonas aeruginosa lung infection in mice
    Melanie R Power
    Department of Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia, Canada
    J Immunol 178:3170-6. 2007
    Toll-IL-1R domain-containing adaptor-inducing IFN-beta (TRIF) is an adaptor molecule that mediates a distinct TLR signaling pathway...
  77. ncbi Tumor immunotherapy using bone marrow-derived dendritic cells overexpressing Toll-like receptor adaptors
    Takashi Akazawa
    Department of Immunology, Osaka Medical Center for Cancer, Nakamichi 1 3 2, Higashinari ku, Osaka 537 8511, Japan
    FEBS Lett 581:3334-40. 2007
    ..TLR agonists work as adjuvants to modulate the function of mDCs. In TLR signaling, MyD88 and TRIF/TICAM-1 are major TLR adaptor molecules, which when overexpressed are able to transduce downstream signals without ..
  78. pmc TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta
    Jonathan C Kagan
    Howard Hughes Medical Institute and Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Nat Immunol 9:361-8. 2008
    Toll-like receptor 4 (TLR4) induces two distinct signaling pathways controlled by the TIRAP-MyD88 and TRAM-TRIF pairs of adaptor proteins, which elicit the production of proinflammatory cytokines and type I interferons, respectively...
  79. pmc Toll-like receptor-4 coordinates the innate immune response of the kidney to renal ischemia/reperfusion injury
    Wilco P Pulskens
    Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    PLoS ONE 3:e3596. 2008
    ..role of TLR4 and the relative contribution of its two downstream signaling cascades, the MyD88-dependent and TRIF-dependent cascades in renal damage by using TLR4-/-, MyD88-/- and TRIF-mutant mice that were subjected to renal ..
  80. doi Innate immune recognition of infected apoptotic cells directs T(H)17 cell differentiation
    Miriam Beer Torchinsky
    Immunology Institute, Department of Medicine, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, New York 10029, USA
    Nature 458:78-82. 2009
    ..Because T(H)17 cells have been correlated with autoimmune diseases, investigation of the pathways of innate recognition of infected apoptotic cells might lead to improved understanding of the causative defects in autoimmunity...
  81. pmc Selective expansion of the monocytic lineage directed by bacterial infection
    Natalya V Serbina
    Infectious Disease Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, Immunology Program, Sloan Kettering Institute, New York, NY 10021, USA
    J Immunol 183:1900-10. 2009
    ..Although MyD88/Trif-mediated signaling is not required for early emigration of the mature monocyte population from the bone marrow, ..
  82. pmc Both TRIF- and MyD88-dependent signaling contribute to host defense against pulmonary Klebsiella infection
    Shanshan Cai
    Department of Pathobiological Sciences, Louisiana State University, Baton Rouge, LA 70803, USA
    J Immunol 183:6629-38. 2009
    Klebsiella pneumoniae causes extensive lung damage. TLR signaling involves adaptors TRIF and MyD88. However, the relative contribution of TRIF and MyD88 signaling in host defense against pulmonary K...
  83. pmc CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer
    Cameron R Stewart
    Lipid Metabolism Unit, Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA
    Nat Immunol 11:155-61. 2010
    ....
  84. pmc Stimulator of IFN gene is critical for induction of IFN-beta during Chlamydia muridarum infection
    Daniel Prantner
    Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    J Immunol 184:2551-60. 2010
    ..In this study, we demonstrate that mouse macrophages lacking TLR3, TRIF, TLR7, or TLR9 individually or both TLR4 and MyD88, still induce IFN-beta equivalent to wild type controls, leading ..
  85. pmc Cutting edge: bacterial infection induces hematopoietic stem and progenitor cell expansion in the absence of TLR signaling
    Philip O Scumpia
    Department of Surgery, University of Florida College of Medicine, Gainesville, FL 32610 0286, USA
    J Immunol 184:2247-51. 2010
    ..treatment in vivo induces TLR4, MyD88, and Toll/IL-1 resistance domain-containing adaptor-inducing IFN-beta (TRIF)-dependent expansion of BM HSPCs...
  86. doi TRIF signaling stimulates translation of TNF-alpha mRNA via prolonged activation of MK2
    Petra Gais
    Department of Surgery, Technical University of Munich, Munich, Germany
    J Immunol 184:5842-8. 2010
    The adapter protein TRIF mediates signal transduction through TLR3 and TLR4, inducing production of type I IFNs and inflammatory cytokines...
  87. pmc Memory CD4+ T cells induce innate responses independently of pathogen
    Tara M Strutt
    Trudeau Institute, Saranac Lake, New York, USA
    Nat Med 16:558-64, 1p following 564. 2010
    ..This represents a previously undescribed mechanism by which memory CD4(+) T cells induce an early innate response that enhances immune protection against pathogens...
  88. pmc Disruption of downstream MyD88 or TRIF Toll-like receptor signaling does not protect against cerebral ischemia
    Bolanle M Famakin
    Stroke Branch, National Institutes of Neurological Disorders and Stroke, National Institutes of Health, 10 Center Drive, Building 10, Rm 5B06, MSC 1401, Bethesda, MD 20892 1401, USA
    Brain Res 1388:148-56. 2011
    ..We thereby investigated involvement of the MyD88-dependent (MyD88) and MyD88-independent (TRIF) TLR signaling pathways in 2 in vitro and 2 in vivo models of cerebral ischemia...
  89. pmc Innate immune recognition of an AT-rich stem-loop DNA motif in the Plasmodium falciparum genome
    Shruti Sharma
    Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
    Immunity 35:194-207. 2011
    ..Collectively, these observations implicate AT-rich DNA sensing via STING, TBK1 and IRF3-IRF7 in P. falciparum malaria...
  90. pmc Toll/interleukin-1 receptor domain-containing adapter inducing interferon-β mediates microglial phagocytosis of degenerating axons
    Suneil Hosmane
    Departments of Biomedical Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    J Neurosci 32:7745-57. 2012
    ..and genetic disruption of Toll/interleukin-1 receptor domain-containing adapter inducing interferon-β (TRIF), a Toll-like receptor adapter protein, blocks induction of the interferon response and inhibits microglial ..
  91. pmc TRIF is required for TLR4 mediated adjuvant effects on T cell clonal expansion
    Siva K Gandhapudi
    Institute for Cellular Therapeutics, University of Louisville School of Medicine, Louisville, Kentucky, United States of America
    PLoS ONE 8:e56855. 2013
    ..TLR4 by its ligands is mediated by engagement of the adapter proteins MyD88 (myeloid differentiation factor 88) and TRIF (Toll-interleukin 1 receptor domain-containing adapter inducing interferon-beta)...
  92. pmc Role of extracellular RNA and TLR3-Trif signaling in myocardial ischemia-reperfusion injury
    Chan Chen
    Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital
    J Am Heart Assoc 3:e000683. 2014
    ..This study examined the role of exRNA and TLR3 signaling in myocardial infarction (MI), apoptosis, inflammation, and cardiac dysfunction during ischemia-reperfusion (I/R) injury...
  93. pmc Chlamydia muridarum infection elicits a beta interferon response in murine oviduct epithelial cells dependent on interferon regulatory factor 3 and TRIF
    Wilbert A Derbigny
    Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Infect Immun 75:1280-90. 2007
    ..in the infected epithelial cell secretion of IFN-beta, we examined the roles of its downstream signaling molecules TRIF and IFN regulatory factor 3 (IRF-3) using a dominant-negative TRIF molecule and siRNA specific for TRIF and IRF-3...
  94. ncbi Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF)-mediated signaling contributes to innate immune responses in the lung during Escherichia coli pneumonia
    Samithamby Jeyaseelan
    Division of Respiratory Infections, Department of Medicine, National Jewish Medical and Research Center, 1400 Jackson Street Neustadt D 403, Denver, CO 80206, USA
    J Immunol 178:3153-60. 2007
    ..Toll/IL-1R domain-containing adaptor inducing IFN-beta (TRIF) is an adaptor for TLR3 and TLR4, and is associated with the MyD88-independent cascade...
  95. pmc Type I interferon signaling is required for activation of the inflammasome during Francisella infection
    Thomas Henry
    Department of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA
    J Exp Med 204:987-94. 2007
    ..This connection underscores the importance of the cytosolic recognition of pathogens and highlights how multiple innate immunity pathways interact before commitment to critical host responses...
  96. ncbi TLR2 is constitutively expressed within the kidney and participates in ischemic renal injury through both MyD88-dependent and -independent pathways
    Alana A Shigeoka
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunol 178:6252-8. 2007
    ..through one of two proximal adapter proteins, MyD88 or Toll/IL-1R domain-containing adaptor-inducing IFN-beta (Trif)...
  97. ncbi IL-27 synthesis induced by TLR ligation critically depends on IFN regulatory factor 3
    Céline Molle
    Institute for Medical Immunology, Universite Libre de Bruxelles, 8 rue Adrienne Bolland, B 6041 Charleroi Gosselies, Belgium
    J Immunol 178:7607-15. 2007
    ..Furthermore, chromatin immunoprecipitation studies demonstrate that IRF3 is recruited to the endogenous p28 promoter in TLR4-stimulated human DCs. We conclude that IRF3 activation is a master switch for IL-27 synthesis...
  98. pmc Innate immunity induced by composition-dependent RIG-I recognition of hepatitis C virus RNA
    Takeshi Saito
    Department of Immunology, University of Washington School of Medicine, Seattle, Washington 98195 7650, USA
    Nature 454:523-7. 2008
    ....
  99. ncbi Mycobacterium paratuberculosis is recognized by Toll-like receptors and NOD2
    Gerben Ferwerda
    Department of Internal Medicine and Nijmegen University Center for Infectious Diseases, Radboud University Nijmegen Medical Center, Geert Grooteplein Zuid 8, 6525 GA Nijmegen, The Netherlands
    J Leukoc Biol 82:1011-8. 2007
    ..and IL-10 production is mediated through MyD88, whereas Toll-IL-1R domain-containing adaptor inducing IFN-beta (TRIF) promoted the release of IL-1beta...
  100. doi Kinetic of RelA activation controls magnitude of TLR-mediated IL-12p40 induction
    Konrad A Bode
    Department of Medical Microbiology and Hygiene, University of Heidelberg, Heidelberg, Germany
    J Immunol 182:2176-84. 2009
    ..It is suggested that differences in the kinetics of a common TLR signaling module affect the biological response patterns of various TLRs, with IL-12p40 being a gene that needs prolonged NF-kappaB activation...
  101. doi Cutting edge: priming of CD8 T cell immunity to herpes simplex virus type 1 requires cognate TLR3 expression in vivo
    Gayle M Davey
    Department of Microbiology and Immunology, The University of Melbourne, Parkville, 3010, Victoria, Australia
    J Immunol 184:2243-6. 2010
    ..These data imply that a cognate linkage between TLR3 and MHC class I is required for efficient CTL priming to HSV-1...

Research Grants17

  1. PAIN EVOKED RELEASE OF AMINO ACIDS AND PROSTANOIDS
    Tony Yaksh; Fiscal Year: 2005
    ....
  2. SIGNIFICANCE OF IMMUNOLOGICAL SEQUESTRATION IN THE EYE
    DALE SANNES GREGERSON; Fiscal Year: 2010
    ..Aim II examines the possibility that local antigen presenting cells are limiting, in number and/or function, thus contributing to retinal immune ignorance and privilege. ..
  3. Local Retinal Antigen Presentation
    DALE SANNES GREGERSON; Fiscal Year: 2010
    ..dendritic cells;or 2. MHC class II on subsets of immune cells in the retina. The ability of circulating antigen presenting cells, or their precursors, to replace these deficiencies in antigen presentation will be tested. ..
  4. PATHOGENESIS OF MURINE SYSTEMIC LUPUS ERYTHEMATOSUS
    DWIGHT KONO; Fiscal Year: 2009
    ..Identification of the susceptibility genes and elucidation of their roles in the induction of lupus should provide significant insights into the etiopathogenesis of genetically-determined autoimmune diseases. ..
  5. Pain Mechanisms and the Development of Analgesics
    Tony Yaksh; Fiscal Year: 2006
    ..g. COX2 inhibitors, GABApentin, ziconotide) and failures (NK1 antagonist). [unreadable] [unreadable] [unreadable]..
  6. NEUROBIOLOGY OF PAIN
    Tony Yaksh; Fiscal Year: 2005
    ..The complexity of the problems and the diversity of the training approaches emphasize that the training received by these fellows will provide a broad base of knowledge relevant to wide areas of neurobiology. ..
  7. Spinal Galanin and its Receptors in Pain Processing
    Tony Yaksh; Fiscal Year: 2005
    ..We believe the outcome of these studies will provide direct evidence for the role played by this spinal peptidergic system in pain and point to the development of novel anti-hyperpathic agents. ..
  8. TOLL RECEPTORS AND CONTROL OF MAMMALIAN IMMUNITY
    Ruslan Medzhitov; Fiscal Year: 2005
    ..Our ultimate goal is to understand whether activation of different TLRs results in the induction of distinct cellular and immune responses. ..
  9. CORNEAL ENDOTHELIAL CELL IMMUNOREGULATORY FACTORS
    DALE GREGERSON; Fiscal Year: 2003
    ..identify the activity(s) to learn if it is a known factor(s); and 3. if the activity has not already been described, continue characterization of the factor(s) and mechanism of action. ..
  10. Donor Antigen-Induced Peripheral Tolerance
    Dianne McKay; Fiscal Year: 2006
    ..We believe that intracellular signaling alterations that lead to alloantigen-induced tolerance may provide novel targets for a new generation of tolerizing immunosuppressive agents. ..
  11. MECHANISMS OF NOVEL ANTI-INFLAMMATORY ACTIONS OF SLPI
    Aihao Ding; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  12. Ehrilchiacidal Mechanisms In Leukocytes
    Yasuko Rikihisa; Fiscal Year: 2009
    ..The results may point to a potential target for new treatment and prevention of HME and HGE. ..
  13. Comparison of Human Ehrlichiosis Agent Genomes
    Yasuko Rikihisa; Fiscal Year: 2010
    ..chaffeensis virulence determinants and their pathogenic mechanisms. The results may point to potential chemotherapy, chemopreventive and/or vaccine candidates for treatment and prevention of human ehrlichiosis. ..
  14. Innate immune responses in lymphatic filariasis
    AMY HISE; Fiscal Year: 2007
    ..abstract_text> ..
  15. Cell Cycle Inhibition in Systemic Autoimmunity
    DWIGHT KONO; Fiscal Year: 2009
    ..These studies should yield important new insights into the significance and role of p21 in systemic autoimmunity and in host response to foreign antigens. ..
  16. B1B lymphocytes generate T cell-independent memory
    KISHORE ALUGUPALLI; Fiscal Year: 2009
    ..Understanding the basis for the longevity of the Tl protective responses conferred by B1b cells will provide novel approaches to generate effective vaccines against pathogens expressing Tl antigens. ..
  17. Heavy Metal-Induced Autoimmunity
    DWIGHT KONO; Fiscal Year: 2005
    ....