Thrb

Summary

Gene Symbol: Thrb
Description: thyroid hormone receptor beta
Alias: Nr1a2, T3R[b], T3Rbeta, Thrb1, Thrb2, c-erbAbeta, thyroid hormone receptor beta, TR beta, c-erbA-2, c-erbA-beta, nuclear receptor subfamily 1 group A member 2
Species: mouse

Top Publications

  1. ncbi Regulation of fibroblast growth factor receptor-1 (FGFR1) by thyroid hormone: identification of a thyroid hormone response element in the murine Fgfr1 promoter
    Patrick J O'Shea
    Gene Regulation Section, Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 4264, USA
    Endocrinology 148:5966-76. 2007
  2. pmc Expression of uncoupling protein 1 in mouse brown adipose tissue is thyroid hormone receptor-beta isoform specific and required for adaptive thermogenesis
    Miriam O Ribeiro
    Molecular Endocrinology Laboratory, Veterans Affairs Greater Los Angeles Healthcare System, 11301 Wilshire Boulevard, Los Angeles, California 90073, USA
    Endocrinology 151:432-40. 2010
  3. ncbi Both thyroid hormone receptor (TR)beta 1 and TR beta 2 isoforms contribute to the regulation of hypothalamic thyrotropin-releasing hormone
    Sandrine M Dupré
    Museum national d histoire naturelle, Unité Scientifique du Muséum 501 Département Régulation, Developpement et Diversite Moleculaire, Centre National de la Recherche Scientifique, Unite Mixte de Recherche, 5166, 75231 Paris Cedex 05, France
    Endocrinology 145:2337-45. 2004
  4. ncbi Distinct tissue-specific roles for thyroid hormone receptors beta and alpha1 in regulation of type 1 deiodinase expression
    L L Amma
    Department of Human Genetics, Mount Sinai School of Medicine New York, New York 10029, USA
    Mol Endocrinol 15:467-75. 2001
  5. ncbi Thyroid hormone receptor-beta (TR beta 1) impairs cell proliferation by the transcriptional inhibition of cyclins D1, E and A2
    E Porlan
    Instituto de Investigaciones Biomedicas Alberto Sols, Consejo Superior de Investigaciones Cientificas Universidad Autonoma de Madrid, Madrid, Spain
    Oncogene 27:2795-800. 2008
  6. ncbi Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor
    A J Hörlein
    Howard Hughes Medical Institute, University of California, San Diego, La Jolla 92093 0648, USA
    Nature 377:397-404. 1995
  7. pmc Recessive resistance to thyroid hormone in mice lacking thyroid hormone receptor beta: evidence for tissue-specific modulation of receptor function
    D Forrest
    Mount Sinai Medical Center, Department of Human Genetics, NY 10029, USA
    EMBO J 15:3006-15. 1996
  8. ncbi Thyroid hormone receptor beta is essential for development of auditory function
    D Forrest
    Mount Sinai School of Medicine, Department of Human Genetics, New York, New York 10029, USA
    Nat Genet 13:354-7. 1996
  9. pmc Constitutive activation of gene expression by thyroid hormone receptor results from reversal of p53-mediated repression
    J S Qi
    Department of Pharmacology, New York University Medical Center, New York 10016, USA
    Mol Cell Biol 17:7195-207. 1997
  10. ncbi Thyroid hormone action on liver, heart, and energy expenditure in thyroid hormone receptor beta-deficient mice
    R E Weiss
    Department of Medicine, The University of Chicago, Illinois 60637, USA
    Endocrinology 139:4945-52. 1998

Research Grants

  1. Human Retinal Progenitor Cells
    Meredithe Applebury; Fiscal Year: 2004
  2. Thyroid Hormone Receptor Isoforms & Coactivators In Vivo
    Roy Weiss; Fiscal Year: 2005
  3. Nuclear cofactors in Human Thyroid Disease
    Roy Weiss; Fiscal Year: 2007
  4. THYROID ACTION IN THE HEART
    Wolfgang Dillmann; Fiscal Year: 2006
  5. Targeting Antioxidant Therapy to Cardiac Mitochondria
    EVAN ABEL; Fiscal Year: 2006
  6. Insulin Signaling and the Heart in Diabetes
    EVAN ABEL; Fiscal Year: 2007
  7. Heart Failure and Thyroid Hormone
    Wolfgang H Dillmann; Fiscal Year: 2010
  8. Insulin resistance and cardiac dysfunction in obesity
    EVAN ABEL; Fiscal Year: 2007
  9. CARDIAC ISCHEMIA AND HSPS
    Wolfgang Dillmann; Fiscal Year: 2008
  10. CARDIAC HYPERTROPHY AND SERCA2 GENE EXPRESSION
    Wolfgang Dillmann; Fiscal Year: 2008

Scientific Experts

Detail Information

Publications114 found, 100 shown here

  1. ncbi Regulation of fibroblast growth factor receptor-1 (FGFR1) by thyroid hormone: identification of a thyroid hormone response element in the murine Fgfr1 promoter
    Patrick J O'Shea
    Gene Regulation Section, Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 4264, USA
    Endocrinology 148:5966-76. 2007
    ..Thus, in addition to indirect regulation of FGFR1 expression by T(3) reported previously, T(3) also activates the Fgfr1 promoter directly via a thyroid hormone response element located at positions -279/-264...
  2. pmc Expression of uncoupling protein 1 in mouse brown adipose tissue is thyroid hormone receptor-beta isoform specific and required for adaptive thermogenesis
    Miriam O Ribeiro
    Molecular Endocrinology Laboratory, Veterans Affairs Greater Los Angeles Healthcare System, 11301 Wilshire Boulevard, Los Angeles, California 90073, USA
    Endocrinology 151:432-40. 2010
    ..Our previous studies with a thyroid hormone receptor-beta (TR beta) isoform-selective agonist demonstrated that after TR beta stimulation alone, adaptive thermogenesis was markedly ..
  3. ncbi Both thyroid hormone receptor (TR)beta 1 and TR beta 2 isoforms contribute to the regulation of hypothalamic thyrotropin-releasing hormone
    Sandrine M Dupré
    Museum national d histoire naturelle, Unité Scientifique du Muséum 501 Département Régulation, Developpement et Diversite Moleculaire, Centre National de la Recherche Scientifique, Unite Mixte de Recherche, 5166, 75231 Paris Cedex 05, France
    Endocrinology 145:2337-45. 2004
    ..This study thus provides functional in vivo data showing that both TRbeta1 and TRbeta2 isoforms have specific roles in regulating TRH transcription...
  4. ncbi Distinct tissue-specific roles for thyroid hormone receptors beta and alpha1 in regulation of type 1 deiodinase expression
    L L Amma
    Department of Human Genetics, Mount Sinai School of Medicine New York, New York 10029, USA
    Mol Endocrinol 15:467-75. 2001
    ..Physiologically, these findings suggest a critical role for TRbeta in regulating the thyroid hormone status through D1-mediated metabolism...
  5. ncbi Thyroid hormone receptor-beta (TR beta 1) impairs cell proliferation by the transcriptional inhibition of cyclins D1, E and A2
    E Porlan
    Instituto de Investigaciones Biomedicas Alberto Sols, Consejo Superior de Investigaciones Cientificas Universidad Autonoma de Madrid, Madrid, Spain
    Oncogene 27:2795-800. 2008
    ..In summary, we propose that apo-TRbeta1 exerts its antiproliferative action through a mechanism that could constitute a model by which other nuclear receptors may control cell division...
  6. ncbi Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor
    A J Hörlein
    Howard Hughes Medical Institute, University of California, San Diego, La Jolla 92093 0648, USA
    Nature 377:397-404. 1995
    ....
  7. pmc Recessive resistance to thyroid hormone in mice lacking thyroid hormone receptor beta: evidence for tissue-specific modulation of receptor function
    D Forrest
    Mount Sinai Medical Center, Department of Human Genetics, NY 10029, USA
    EMBO J 15:3006-15. 1996
    ..is normally suppressed by increased levels of thyroid hormone, was present at elevated levels in homozygous mutant (Thrb-/-) mice...
  8. ncbi Thyroid hormone receptor beta is essential for development of auditory function
    D Forrest
    Mount Sinai School of Medicine, Department of Human Genetics, New York, New York 10029, USA
    Nat Genet 13:354-7. 1996
    ..Two T3 receptor genes, Tr alpha and Tr beta are differentially expressed, although in overlapping patterns, during development...
  9. pmc Constitutive activation of gene expression by thyroid hormone receptor results from reversal of p53-mediated repression
    J S Qi
    Department of Pharmacology, New York University Medical Center, New York 10016, USA
    Mol Cell Biol 17:7195-207. 1997
    ....
  10. ncbi Thyroid hormone action on liver, heart, and energy expenditure in thyroid hormone receptor beta-deficient mice
    R E Weiss
    Department of Medicine, The University of Chicago, Illinois 60637, USA
    Endocrinology 139:4945-52. 1998
    ..However, their relative roles in the regulation of specific gene expression remain unknown. The TR beta knockout mouse, which lacks both TR beta1 and TR beta2 isoforms, provides a model to examine the role of these ..
  11. pmc Mice devoid of all known thyroid hormone receptors are viable but exhibit disorders of the pituitary-thyroid axis, growth, and bone maturation
    S Gothe
    Laboratory of Developmental Biology, CMB, Karolinska Institute, Stockholm, S 17 177, Sweden
    Genes Dev 13:1329-41. 1999
    ..These distinctions suggest that T3-independent actions of T3 receptors, demonstrated previously in vitro, may be a significant function in vivo...
  12. pmc Mice with a targeted mutation in the thyroid hormone beta receptor gene exhibit impaired growth and resistance to thyroid hormone
    M Kaneshige
    Laboratory of Molecular Biology, National Cancer Institute, and Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 97:13209-14. 2000
    Patients with mutations in the thyroid hormone receptor beta (TRbeta) gene manifest resistance to thyroid hormone (RTH), resulting in a constellation of variable phenotypic abnormalities...
  13. ncbi Patterns of liver gene expression governed by TRbeta
    Amilcar Flores-Morales
    Department of Molecular Medicine, Karolinska Institute, Stockholm 17176, Sweden
    Mol Endocrinol 16:1257-68. 2002
    ....
  14. ncbi Mice with a mutation in the thyroid hormone receptor beta gene spontaneously develop thyroid carcinoma: a mouse model of thyroid carcinogenesis
    Hideyo Suzuki
    Gene Regulation Section, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892 4264, USA
    Thyroid 12:963-9. 2002
    ....
  15. pmc Effects of ligand and thyroid hormone receptor isoforms on hepatic gene expression profiles of thyroid hormone receptor knockout mice
    Paul M Yen
    Molecular Regulation and Neuroendocrinology Section, Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases NIH, Room 8D12, Building 10, Bethesda, MD 20892, USA
    EMBO Rep 4:581-7. 2003
    ..We used 48 complementary DNA microarrays to examine hepatic gene expression profiles of wild-type and Thra and Thrb knockout mice under different Th conditions: no treatment, treatment with 3,3',5-triiodothyronine (T(3)), Th-..
  16. ncbi Alterations in genomic profiles during tumor progression in a mouse model of follicular thyroid carcinoma
    Hao Ying
    Laboratory of Molecular Biology, National Cancer Institute, Winston Salem, NC 27157 1072, USA
    Carcinogenesis 24:1467-79. 2003
    ..We have recently created a mutant mouse by targeting a mutation (PV) into the thyroid hormone receptor beta gene (TRbetaPV mouse)...
  17. ncbi Mutant thyroid hormone receptor beta represses the expression and transcriptional activity of peroxisome proliferator-activated receptor gamma during thyroid carcinogenesis
    Hao Ying
    Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892 4264, USA
    Cancer Res 63:5274-80. 2003
    ....
  18. ncbi AKT activation promotes metastasis in a mouse model of follicular thyroid carcinoma
    Caroline S Kim
    Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, 37 Convent Drive, Room 5128, Bethesda, Maryland 20892 4264, USA
    Endocrinology 146:4456-63. 2005
    ..Thus, TRbeta(PV/PV) mice could be used to further dissect the detailed pathways underlying the progression and metastasis of follicular thyroid carcinoma...
  19. ncbi Retinoid X receptor (gamma) is necessary to establish the S-opsin gradient in cone photoreceptors of the developing mouse retina
    Melanie R Roberts
    Graduate Program in Neurobiology and Behavior, University of Washington, Seattle, WA, USA
    Invest Ophthalmol Vis Sci 46:2897-904. 2005
    ..Thyroid hormone receptors often regulate gene transcription as heterodimeric complexes with RXRs...
  20. pmc Activation of phosphatidylinositol 3-kinase signaling by a mutant thyroid hormone beta receptor
    Fumihiko Furuya
    Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 4264, USA
    Proc Natl Acad Sci U S A 103:1780-5. 2006
    ..Importantly, the present study unveils a mechanism by which a mutant TR acts to activate PI3K activity via protein-protein interactions...
  21. ncbi Transgenic mice expressing a human mutant beta1 thyroid receptor are hyperactive, impulsive, and inattentive
    W B Siesser
    Program in Neuroscience, Vanderbilt University, Nashville, TN 37232 0325, USA
    Genes Brain Behav 5:282-97. 2006
    ..This suggests that even transient perturbations in developmental thyroid homeostasis can have long-lasting behavioral and cognitive consequences, including producing the full spectrum of symptoms of ADHD...
  22. pmc Making the gradient: thyroid hormone regulates cone opsin expression in the developing mouse retina
    Melanie R Roberts
    Graduate Program in Neurobiology and Behavior and Department of Biological Structure, University of Washington, Box 357420, Seattle, WA 98195 7420, USA
    Proc Natl Acad Sci U S A 103:6218-23. 2006
    ..These results also suggest that the ratio and patterning of cone types may be determined by TH availability during retinal development...
  23. pmc Aberrant accumulation of PTTG1 induced by a mutated thyroid hormone beta receptor inhibits mitotic progression
    Hao Ying
    Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
    J Clin Invest 116:2972-84. 2006
    ..The loss of this regulatory function in PV led to an aberrant accumulation of PTTG1 disrupting mitotic progression that could contribute to thyroid carcinogenesis...
  24. ncbi The pituitary tumor-transforming gene promotes angiogenesis in a mouse model of follicular thyroid cancer
    Caroline S Kim
    Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, 37 Convent Drive, Room 5128, Bethesda, MD 20892 4264, USA
    Carcinogenesis 28:932-9. 2007
    ..The separation of the pathways regulating cell proliferation, tumor initiation and tumor progression should direct future therapeutic options...
  25. ncbi Gelsolin: a novel thyroid hormone receptor-beta interacting protein that modulates tumor progression in a mouse model of follicular thyroid cancer
    Caroline S Kim
    Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, 37 Convent Drive, Bethesda, MD 20892 4264, USA
    Endocrinology 148:1306-12. 2007
    ..Thus, the present study uncovered a novel PV-mediated oncogenic pathway that could contribute to the local tumor progression and metastatic potential of thyroid carcinogenesis...
  26. pmc Nuclear receptor corepressor is a novel regulator of phosphatidylinositol 3-kinase signaling
    Fumihiko Furuya
    Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 37 Convent Dr, Room 5128, Bethesda, MD 20892 4264, USA
    Mol Cell Biol 27:6116-26. 2007
    ..Taken together, these results indicate that NCoR, via protein-protein interaction, is a novel regulator of PI3K signaling and could serve to modulate thyroid tumor progression...
  27. ncbi Inhibition of phosphatidylinositol 3-kinase delays tumor progression and blocks metastatic spread in a mouse model of thyroid cancer
    Fumihiko Furuya
    Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Carcinogenesis 28:2451-8. 2007
    ..This TRbeta(PV/PV) mouse harbors a knockin mutant thyroid hormone receptor beta gene (TRbetaPV mutant) that spontaneously develops thyroid cancer and distant metastasis similar to ..
  28. doi Thyroid hormone action is required for normal cone opsin expression during mouse retinal development
    Cristiano N Pessôa
    Instituto de Biofisica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, CCS, Cidade Universitaria, Ilha do Fundao, Rio de Janeiro, Brazil
    Invest Ophthalmol Vis Sci 49:2039-45. 2008
    ....
  29. pmc Regulation of beta-catenin by a novel nongenomic action of thyroid hormone beta receptor
    Celine J Guigon
    Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 4264, USA
    Mol Cell Biol 28:4598-608. 2008
    We previously created a knock-in mutant mouse harboring a dominantly negative mutant thyroid hormone receptor beta (TRbeta(PV/PV) mouse) that spontaneously develops a follicular thyroid carcinoma similar to human thyroid cancer...
  30. doi Retinoic acid receptor-related orphan receptor alpha regulates a subset of cone genes during mouse retinal development
    Hiroki Fujieda
    Department of Anatomy, School of Medicine, Tokyo Women s Medical University, Tokyo, Japan
    J Neurochem 108:91-101. 2009
    ..Our data suggest that RORalpha plays a crucial role in cone development by directly regulating multiple cone genes...
  31. pmc The nuclear corepressor, NCoR, regulates thyroid hormone action in vivo
    Inna Astapova
    Division of Endocrinology, Metabolism and Diabetes, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 105:19544-9. 2008
    ..Interestingly, NCoR recruitment to LXR is also impaired in this model, leading to activation of LXR-target genes, further demonstrating that NCoR recruitment regulates multiple nuclear receptor signaling pathways...
  32. pmc Growth activation alone is not sufficient to cause metastatic thyroid cancer in a mouse model of follicular thyroid carcinoma
    Changxue Lu
    Laboratory of Molecular Biology, National Cancer Institute, 37 Convent Drive, Room 5128, Bethesda, Maryland 20892 4264, USA
    Endocrinology 151:1929-39. 2010
    ..These in vivo findings provide new insights in understanding carcinogenesis of the human thyroid...
  33. pmc Inhibition of mTORC1 signaling reduces tumor growth but does not prevent cancer progression in a mouse model of thyroid cancer
    Celine J Guigon
    Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892 4264, USA
    Carcinogenesis 31:1284-91. 2010
    ..In conclusion, our work underscores that in the treatment of FTC patients, RAD001 can only be used in combination with drugs and therapies inducing tumor shrinkage and blocking metastasis...
  34. pmc Pias3-dependent SUMOylation controls mammalian cone photoreceptor differentiation
    Akishi Onishi
    Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Nat Neurosci 13:1059-65. 2010
    ....
  35. pmc The thyroid hormone receptors as modulators of skin proliferation and inflammation
    Constanza Contreras-Jurado
    Instituto de Investigaciones Biomédicas de Madrid, Consejo Superior de Investigaciones Cientificas, and Universidad Autónoma de Madrid, 28029 Madrid, Spain
    J Biol Chem 286:24079-88. 2011
    ....
  36. pmc The thyroid hormone receptors modulate the skin response to retinoids
    Laura García-Serrano
    Instituto de Investigaciones Biomedicas, Consejo Superior de Investigaciones Cientificas and Universidad Autonoma de Madrid, Madrid, Spain
    PLoS ONE 6:e23825. 2011
    ....
  37. pmc Resistance to thyroid hormone is modulated in vivo by the nuclear receptor corepressor (NCOR1)
    Laura Fozzatti
    Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 108:17462-7. 2011
    ..To test this hypothesis in vivo, we crossed Thrb(PV) mice (a model of RTH) expressing a human TRβ mutant (PV) with mice expressing a mutant Ncor1 allele (Ncor1(Δ..
  38. ncbi Functions of thyroid hormone receptors in mice
    D Forrest
    Department of Human Genetics, Mount Sinai School of Medicine, New York, New York 10029, USA
    Thyroid 10:41-52. 2000
    ..The TR-deficient mouse models have allowed investigation of the TR pathways underlying many functions of thyroid hormone and provide a unique perspective on receptor-mediated mechanisms of biological control...
  39. ncbi A thyroid hormone receptor that is required for the development of green cone photoreceptors
    L Ng
    Department of Human Genetics, Box 1498, Mount Sinai School of Medicine, New York, New York, USA
    Nat Genet 27:94-8. 2001
    ..b>Thyroid hormone receptor beta 2 (TR beta 2) is a ligand-activated transcription factor that is expressed in the outer nuclear layer ..
  40. ncbi Transient expression of thyroid hormone nuclear receptor TRbeta2 sets S opsin patterning during cone photoreceptor genesis
    M L Applebury
    The Howe Laboratory, Harvard Medical School and Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
    Dev Dyn 236:1203-12. 2007
    ..TR beta 2, the nuclear thyroid hormone receptor beta isoform 2, regulates dorsal repression...
  41. ncbi GH substitution reverses the growth phenotype but not the defective ossification in thyroid hormone receptor alpha 1-/-beta-/- mice
    J M Kindblom
    Research Center of Endocrinology and Metabolism, Department of Internal Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden
    J Endocrinol 171:15-22. 2001
    ..Our data suggest that TRs are of importance both for the regulation of the GH/IGF-I axis and for direct effects on cartilage...
  42. ncbi Specificity of thyroid hormone receptor subtype and steroid receptor coactivator-1 on thyroid hormone action
    Peter M Sadow
    Departments of Medicine and Pathology, University of Chicago, Illinois 60637, USA
    Am J Physiol Endocrinol Metab 284:E36-46. 2003
    ....
  43. ncbi A mouse model of resistance to thyroid hormone produced by somatic gene transfer of a mutant thyroid hormone receptor
    Y Hayashi
    Department of Medicine, University of Chicago, Illinois 60637, USA
    Mol Endocrinol 10:100-6. 1996
    ..characterized by hyposensitivity to thyroid hormone caused by mutations in the thyroid hormone receptor-beta (TR beta) gene...
  44. ncbi Involvement of T3Ralpha- and beta-receptor subtypes in mediation of T3 functions during postnatal murine intestinal development
    M Plateroti
    INSERM Unite 381, Strasbourg, France
    Gastroenterology 116:1367-78. 1999
    ..Their effects are mediated by nuclear receptors, which are transcriptional regulators activated upon binding of triiodothyronine. The aim of this study was to define the involvement of the receptor subtypes during intestinal development...
  45. ncbi Cardiovascular phenotype and temperature control in mice lacking thyroid hormone receptor-beta or both alpha1 and beta
    C Johansson
    Department of Physiology and Pharmacology, Karolinska Institute, S 171 77 Stockholm, Sweden
    Am J Physiol 276:H2006-12. 1999
    ..Our present and previous results support the hypothesis that TR-alpha1 has a major role in determining heart rate under baseline conditions and body temperature and that TR-beta mediates a hormone-induced increase in heart rate...
  46. ncbi Expression of peptides and other neurochemical markers in hypothalamus and olfactory bulb of mice devoid of all known thyroid hormone receptors
    L Calza
    Department of Veterinary Morphophysiology and Animal Production DIMORFIPA, University of Bologna, Via Tolara di Sopra 50, 40064 Ozzano Emilia, Bologna, Italy
    Neuroscience 101:1001-12. 2000
    ..Together these studies reveal many regional and neurochemically selective alterations in neuronal phenotype of mice devoid of all known thyroid hormone receptors...
  47. ncbi Cardiac ion channel expression and contractile function in mice with deletion of thyroid hormone receptor alpha or beta
    B Gloss
    Division of Endocrinology and Metabolism, University of California, San Diego, La Jolla, California 92093, USA
    Endocrinology 142:544-50. 2001
    ..We conclude that the cardiac phenotype regulated by T(3) is predominantly mediated by T(3)Ralpha and that the lack of T(3)Ralpha cannot be compensated by T(3)Rss in the heart...
  48. ncbi Thyroid hormone receptor-specific interactions with steroid receptor coactivator-1 in the pituitary
    Peter M Sadow
    Department of Medicine, University of Chicago, Illinois, USA
    Mol Endocrinol 17:882-94. 2003
    ..We conclude that SRC-1 action in the pituitary mediates TH action via specific TR subtypes...
  49. ncbi A thyrotoxic skeletal phenotype of advanced bone formation in mice with resistance to thyroid hormone
    Patrick J O'Shea
    Molecular Endocrinology Group, Division of Medicine and Medical Research Council Clinical Sciences Centre, Faculty of Medicine, Imperial College London, Hammersmith Hospital, United Kingdom
    Mol Endocrinol 17:1410-24. 2003
    ..Thus, the skeleton in TRbetaPV/PV mice is thyrotoxic and displays phenotypic features typical of juvenile hyperthyroidism...
  50. ncbi Modulation by steroid receptor coactivator-1 of target-tissue responsiveness in resistance to thyroid hormone
    Yuji Kamiya
    Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892 4264, USA
    Endocrinology 144:4144-53. 2003
    Mutations in the thyroid hormone receptor-beta gene (TR beta) cause resistance to thyroid hormone. How the action of mutant thyroid hormone nuclear receptors (TRs) is regulated in vivo is not clear...
  51. pmc Distinct dysregulation of lipid metabolism by unliganded thyroid hormone receptor isoforms
    O Araki
    Laboratory of Molecular Biology, National Cancer Institute, 37 Convent Drive, Room 5128, Bethesda, Maryland 20892 4264, USA
    Mol Endocrinol 23:308-15. 2009
    ..These results indicate that apo-TRbeta and apo-TRalpha1 had different effects on lipid metabolism and that both TR isoforms contribute to the pathogenesis of lipid metabolism in hypothyroidism...
  52. doi Thyroid hormone receptor β mediates acute illness-induced alterations in central thyroid hormone metabolism
    A Boelen
    Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, The Netherlands
    J Neuroendocrinol 21:465-72. 2009
    ..Our results suggest that TRβ is involved in suppression of the central component of the hypothalamic-pituitary-thyroid axis in acute illness...
  53. doi Wnt/Lef1 signaling acts via Pitx2 to regulate somite myogenesis
    Muhammad Abu-Elmagd
    University of East Anglia, School of Biological Sciences, Norwich, NR4 7TJ Earlham Road, UK
    Dev Biol 337:211-9. 2010
    ....
  54. pmc Temporal requirement of the protein tyrosine phosphatase Shp2 in establishing the neuronal fate in early retinal development
    Zhigang Cai
    Department of Medical and Molecular Genetics, Stark Neuroscience Institute, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Neurosci 30:4110-9. 2010
    ..Together, these results demonstrate that Shp2 mediates FGF-Ras signaling to control retinal progenitor cell fate...
  55. pmc Loss of thyroid hormone receptor β is associated with increased progenitor proliferation and NeuroD positive cell number in the adult hippocampus
    Richa Kapoor
    Department of Biological Sciences, Tata Institute of Fundamental Research, Mumbai 400005, India
    Neurosci Lett 487:199-203. 2011
    ..Taken together, our results provide novel evidence for a role of TRβ in modulating hippocampal progenitor cell division, and implicate this receptor in the effects of thyroid hormone on adult hippocampal neurogenesis...
  56. pmc NCoR1 regulates thyroid hormone receptor isoform-dependent adipogenesis
    Xu Guang Zhu
    Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Center for Cancer Research, 37 Convent Drive, Room 5128, Bethesda, Marryland 20892 4264, USA
    J Mol Endocrinol 46:233-44. 2011
    ....
  57. pmc Diet-induced obesity increases tumor growth and promotes anaplastic change in thyroid cancer in a mouse model
    Won Gu Kim
    Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892 4264, USA
    Endocrinology 154:2936-47. 2013
    ..of diet-induced obesity on thyroid carcinogenesis in a mouse model that spontaneously develops thyroid cancer (Thrb(PV/PV)Pten(+/-) mice)...
  58. pmc FoxO1 deacetylation regulates thyroid hormone-induced transcription of key hepatic gluconeogenic genes
    Brijesh Kumar Singh
    From the Laboratory of Hormonal Regulation, Cardiovascular and Metabolic Disorders Program, Duke NUS Graduate Medical School, Singapore 169857
    J Biol Chem 288:30365-72. 2013
    ..In summary, our results show that TH-dependent deacetylation of a second metabolically regulated transcription factor represents a novel mechanism for transcriptional integration of nuclear hormone action with cellular energy status. ..
  59. pmc The thyroid hormone receptor β induces DNA damage and premature senescence
    Alberto Zambrano
    Instituto de Investigaciones Biomedicas Alberto Sols, Consejo Superior de Investigaciones Cientificas and Universidad Autonoma de Madrid, 28029 Madrid, Spain
    J Cell Biol 204:129-46. 2014
    ..In this paper, we demonstrate that binding of TH T3 (triiodothyronine) to THRB induces senescence and deoxyribonucleic acid (DNA) damage in cultured cells and in tissues of young hyperthyroid ..
  60. doi Thyroid hormone receptor regulates most genes independently of fibroblast growth factor 21 in liver
    Aijun Zhang
    Houston Methodist Research InstituteGenomic Medicine Program, 6670 Bertner Ave, Houston, Texas 77030, USACollege of Arts and SciencesChemistry Department, Indiana University Bloomington, Bloomington, Indiana, USADepartments of PaediatricsOncology, and Physiology and Pharmacology, University of Western Ontario, London, Ontario, CanadaChildren s Health Research InstituteLondon, Ontario, CanadaDepartment of Molecular Physiology and BiophysicsBaylor College of Medicine, Houston, Texas, USAThe Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhou, China
    J Endocrinol 224:289-301. 2015
    ..Our findings indicate that T3 regulates the genes involved in classical hepatic metabolic responses independently of FGF21. ..
  61. pmc Thyroid hormones inhibit TGF-β signaling and attenuate fibrotic responses
    Elvira Alonso-Merino
    Instituto de Investigaciones Biomedicas Alberto Sols, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, 20829 Madrid, Spain
    Proc Natl Acad Sci U S A 113:E3451-60. 2016
    ..These findings define an important function of the thyroid hormone receptors and suggest TR ligands could have beneficial effects to block the progression of fibrotic diseases...
  62. pmc Thyroid hormone receptor isoform-specific modification by small ubiquitin-like modifier (SUMO) modulates thyroid hormone-dependent gene regulation
    Yan Yun Liu
    Molecular Endocrinology Laboratory, Department of Medicine, Veterans Affairs Greater Los Angeles Healthcare System and David Geffen School of Medicine at UCLA, Los Angeles, California 90073, USA
    J Biol Chem 287:36499-508. 2012
    ..These findings demonstrate that conjugation of SUMO to TR has a TR-isoform preference and is important for T3-dependent gene induction and repression...
  63. ncbi Negative regulation of the gene for the preprothyrotropin-releasing hormone from the mouse by thyroid hormone requires additional factors in conjunction with thyroid hormone receptors
    T Satoh
    First Department of Internal Medicine, Gunma University School of Medicine, 3 39 15 Showa Machi, Maebashi 371, Japan
    J Biol Chem 271:27919-26. 1996
    ..These results indicate that the negative regulation of murine ppTRH gene by T3 might be mediated by the cooperation of T3R monomers with unknown factor(s) interacting with the element downstream of the TSS...
  64. ncbi Thyrotropin regulation by thyroid hormone in thyroid hormone receptor beta-deficient mice
    R E Weiss
    Department of Medicine, The University of Chicago, Illinois 60637, USA
    Endocrinology 138:3624-9. 1997
    ..alpha and beta genes are expressed in the pituitary gland, it is unclear what the relative roles of TR alpha and TR beta are in TSH regulation. Experiments using over expression of artificial genes have yielded conflicting results...
  65. ncbi Regulation of the mouse cellular retinoic acid-binding protein-I gene by thyroid hormone and retinoids in transgenic mouse embryos and P19 cells
    L N Wei
    Department of Pharmacology, University of Minnesota Medical School, Minneapolis 55455, USA
    J Endocrinol 155:35-46. 1997
    ..A role of thyroid hormones in CRABP-I gene expression and vitamin A metabolism in animals is discussed...
  66. ncbi Differential gene expression at gestational days 14 and 16 in normal and nitrogen-induced hypoplastic murine fetal lungs with coexistent diaphragmatic hernia
    R A Causak
    Department of Surgery, Pennsylvania State University College of Medicine, Hershey 17033, USA
    Pediatr Pulmonol 26:301-11. 1998
    ..Our results may shed some light on regulatory aspects of lung development and open avenues for treatment of hypoplastic lungs and other respiratory problems in human neonates...
  67. pmc Thyroid hormone receptor beta-dependent expression of a potassium conductance in inner hair cells at the onset of hearing
    A Rusch
    Physiologisches Institut, Gmelinstrasse 5, and Sektion Sensorische Biophysik, Hals Nasen Ohren Klinik, Röntgenweg 11, Universität T ubingen, D 72076 Tubingen, Germany
    Proc Natl Acad Sci U S A 95:15758-62. 1998
    ..These results establish that the physiological differentiation of IHCs depends on a TRbeta-mediated pathway. When defective, this may contribute to deafness in congenital thyroid diseases...
  68. pmc Different functions for the thyroid hormone receptors TRalpha and TRbeta in the control of thyroid hormone production and post-natal development
    K Gauthier
    CNRS UMR 49 INRA LA 913, Ecole Normale Superieure, 46 allee d Italie, 69364 Lyon, France
    EMBO J 18:623-31. 1999
    ..We conclude that each of the two families of proteins mediate specific functions of triiodothyronin (T3), and that redundancy is only partial and concerns a limited number of functions...
  69. pmc Increased sensitivity to thyroid hormone in mice with complete deficiency of thyroid hormone receptor alpha
    P E Macchia
    Department of Medicine, University of Chicago, MC 3090, 5841 South Maryland Avenue, Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 98:349-54. 2001
    ..This is an in vivo demonstration that a TR deficiency can enhance sensitivity to TH. This effect is likely due to the abrogation of the constitutive "silencing" effect of TRalpha2 in tissues expressing the TRbeta isoforms...
  70. ncbi Audiogenic seizure susceptibility in thyroid hormone receptor beta-deficient mice
    L Ng
    Department of Human Genetics, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, NY 10029, USA
    Neuroreport 12:2359-62. 2001
    ..hypothyroidism produces audiogenic seizure susceptibility (AGS) in rodents, the role of TR alpha 1 and TR beta thyroid hormone receptors in AGS was investigated...
  71. ncbi Suppression of the deafness and thyroid dysfunction in Thrb-null mice by an independent mutation in the Thra thyroid hormone receptor alpha gene
    L Ng
    Department of Human Genetics, Box 1498, Mount Sinai School of Medicine, 1425 Madison Avenue, New York, NY 10029, USA
    Hum Mol Genet 10:2701-8. 2001
    Deletion of thyroid hormone receptor beta (TR beta), a ligand-dependent transcription factor encoded by the Thrb gene, causes deafness and thyroid hyperactivity in Thrb-null (Thrb(tm1/tm1)) mice and in a recessive form of the human ..
  72. ncbi Biallelic inactivation of the thyroid hormone receptor beta1 gene in early stage breast cancer
    Zheng Li
    Geraldine Brush Cancer Research Institute, California Pacific Medical Center, San Francisco, California 94115, USA
    Cancer Res 62:1939-43. 2002
    ..The observation of early, frequent, and multiple mechanisms of TRbeta1 inactivation suggests a potential role for this gene in the suppression of breast tumorigenesis...
  73. pmc Retardation of post-natal development caused by a negatively acting thyroid hormone receptor alpha1
    Alexander Tinnikov
    Department of Cell and Molecular Biology, Department of Physiology and Pharmacology, Microbiology and Tumour Biology Center, Karolinska Institute, S 177 71 Stockholm, Sweden
    EMBO J 21:5079-87. 2002
    Most patients with the syndrome resistance to thyroid hormone (RTH) express a mutant thyroid hormone receptor beta (TRbeta) with transdominant negative transcriptional effects...
  74. ncbi Thyroid hormone receptor-beta mutations conferring hormone resistance and reduced corepressor release exhibit decreased stability in the N-terminal ligand-binding domain
    B Russell Huber
    Graduate Group in Biophysics, University of California, San Francisco, California 94143 0448, USA
    Mol Endocrinol 17:107-16. 2003
    ..Thus, these structural analyses provide mechanistic insight into the etiology of RTH disease in human TRbeta mutants that exhibit hormone binding with decreased ligand-dependent corepressor release...
  75. pmc Isometric force and endurance in skeletal muscle of mice devoid of all known thyroid hormone receptors
    Catarina Johansson
    Department of Physiology and Pharmacology, Karolinska Institute, S 171 77 Stockholm, Sweden
    J Physiol 547:789-96. 2003
    ..Thus, in skeletal muscle there seems to be functional overlap between TRalpha1 and TRbeta, so that the lack of one of the receptors to some extent can be compensated for by the presence of the other...
  76. ncbi Thyroid hormone receptors: lessons from knockout and knock-in mutant mice
    Frederic Flamant
    Laboratoire de Biologie Moléculaire et Cellulaire de l Ecole Normale Supérieure de Lyon UMR CNRS 5665 LA INRA 913, 46 Allée d Italie 69364 Lyon CEDEX07, France
    Trends Endocrinol Metab 14:85-90. 2003
    ....
  77. ncbi Microarray analysis of knockout mice identifies cyclin D2 as a possible mediator for the action of thyroid hormone during the postnatal development of the cerebellum
    Anne Lise Poguet
    Laboratoire de Biologie Moléculaire et Cellulaire de l Ecole Normale Supérieure de Lyon UMR CNRS 5665 LA INRA913, 46 Allée d ltalie 69364 Lyon CEDEX07France
    Dev Biol 254:188-99. 2003
    ....
  78. pmc Thyroid hormone action in the absence of thyroid hormone receptor DNA-binding in vivo
    Nobuyuki Shibusawa
    Department of Medicine, University of Chicago, 5841 S Maryland Avenue, MC1027, Chicago, Illinois 60637, USA
    J Clin Invest 112:588-97. 2003
    ..Inner ear development, although not completely normal, can occur in the absence of TR DNA-binding, suggesting that an alternative and perhaps novel thyroid hormone-signaling pathway may mediate these effects...
  79. ncbi Thyroid hormone resistance in the heart: role of the thyroid hormone receptor beta isoform
    Tania M Ortiga-Carvalho
    Department of Medicine, Pritzker School of the Medicine, The University of Chicago, Illinois 60637, USA
    Endocrinology 145:1625-33. 2004
    ..In contrast, HR in KS-mut animals did not change after either treatment. Except for cardiac hypertrophy, the presence of a germline TR-beta mutation had surprisingly little effect on cardiac function...
  80. ncbi Mixed lineage kinase 2 enhances trans-repression of Alien and nuclear receptors
    Maren Eckey
    Genetic Institute, Justus Liebig University, Heinrich Buff Ring 58 62, D 35392 Giessen, Germany
    Mol Cell Endocrinol 213:71-8. 2003
    ..This novel cross-talk may represent a link between MLK2-mediated signaling and transcriptional repression of target genes during neuronal differentiation processes...
  81. ncbi A tumor suppressor role for thyroid hormone beta receptor in a mouse model of thyroid carcinogenesis
    Yasuhito Kato
    Laboratory of Molecular Biology, National Cancer Institute, 37 Convent Drive, Room 5128, Bethesda, Maryland 20892 4264, USA
    Endocrinology 145:4430-8. 2004
    We have created a knockin mutant mouse by targeting a mutation (PV) into the thyroid hormone receptor beta gene (TRbetaPV mouse). TRbetaPV/PV mice, but not TRbetaPV/+ mice, spontaneously develop follicular thyroid carcinoma...
  82. ncbi Cardiac glucose utilization in mice with mutated alpha- and beta-thyroid hormone receptors
    Takanori Esaki
    Laboratory of Cerebral Metabolism, National Institute of Mental Health, Bldg no 36, Rm 1A 07, 36 Convent Drive MSC 4030, Bethesda, MD 20892, USA
    Am J Physiol Endocrinol Metab 287:E1149-53. 2004
    ....
  83. ncbi Unliganded thyroid hormone receptor beta1 inhibits proliferation of murine fibroblasts by delaying the onset of the G1 cell-cycle signals
    Eva Porlan
    Instituto de Investigaciones Biomedicas Alberto Sols, Consejo Superior de Investigaciones Cientificas Universidad Autonoma de Madrid, Arturo Duperier, 4, Madrid 28029, Spain
    Oncogene 23:8756-65. 2004
    ..The unliganded TRbeta1 impairs the normal induction of the G1/S cycle regulators preventing progression into the S phase...
  84. ncbi Contrasting skeletal phenotypes in mice with an identical mutation targeted to thyroid hormone receptor alpha1 or beta
    Patrick J O'Shea
    Molecular Endocrinology Group, 5th Floor Clinical Research Building, Medical Research Council Clinical Sciences Centre, Hammersmith Hospital, Du Cane Road, London W12 0NN, United Kingdom
    Mol Endocrinol 19:3045-59. 2005
    ..These studies provide a new understanding of the complex relationship between central and peripheral thyroid status...
  85. pmc Thyroid hormone receptor beta mutants: Dominant negative regulators of peroxisome proliferator-activated receptor gamma action
    Osamu Araki
    Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 4264, USA
    Proc Natl Acad Sci U S A 102:16251-6. 2005
    ....
  86. ncbi PPARgamma insufficiency promotes follicular thyroid carcinogenesis via activation of the nuclear factor-kappaB signaling pathway
    Y Kato
    Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 4264, USA
    Oncogene 25:2736-47. 2006
    ..Mice harboring a knock-in dominantly negative mutant thyroid hormone receptor beta (TRbetaPV/PV mouse) spontaneously develop follicular thyroid carcinoma similar to human thyroid cancer...
  87. ncbi The dominant negative thyroid hormone receptor beta-mutant {Delta}337T alters PPAR{alpha} signaling in heart
    Norman E Buroker
    Division of Cardiology, Children s Hospital and Regional Medical Center, 4800 Sand Point Way N E, Seattle, WA 98105, USA
    Am J Physiol Endocrinol Metab 292:E453-60. 2007
    ..These results indicate that therapeutic response to PPARalpha ligands may be determined by thyroid hormone state and TR function...
  88. ncbi Genetic alterations in thyroid cancer: the role of mouse models
    K A B Knostman
    Department of Veterinary Biosciences, Ohio State University, 1925 Coffey Road, Columbus, Ohio 43210, USA
    Vet Pathol 44:1-14. 2007
    ..Limitations of each model are presented, and the need for additional models to better recapitulate certain aspects of the human disease is discussed...
  89. ncbi Adeno-associated virus-mediated expression of thyroid hormone receptor isoforms-alpha1 and -beta1 improves contractile function in pressure overload-induced cardiac hypertrophy
    Darrell D Belke
    Department of Medicine, 5063 Basic Sciences Building, University of California San Diego, La Jolla, CA 92093 0618, USA
    Endocrinology 148:2870-7. 2007
    ..These results demonstrate that increasing TR expression in the hypertrophied heart is associated with an improvement in contractile function and increased SERCA expression...
  90. ncbi Thyroid hormone excess rather than thyrotropin deficiency induces osteoporosis in hyperthyroidism
    J H Duncan Bassett
    Molecular Endocrinology Group, Division of Medicine and Medical Research Council MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital, London W12 0NN, United Kingdom
    Mol Endocrinol 21:1095-107. 2007
    ..These studies demonstrate that bone loss in thyrotoxicosis is independent of circulating TSH levels and mediated predominantly by TRalpha, thus identifying TRalpha as a novel drug target in the prevention and treatment of osteoporosis...
  91. ncbi The steroid receptor coactivator-3 is a tumor promoter in a mouse model of thyroid cancer
    H Ying
    Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 4264, USA
    Oncogene 27:823-30. 2008
    ..Taken together, SRC-3 could play important roles through regulating multiple target genes and signaling pathways during thyroid carcinogenesis, understanding of which should direct future therapeutic options for thyroid cancer...
  92. pmc Hypermetabolism in mice caused by the central action of an unliganded thyroid hormone receptor alpha1
    Maria Sjogren
    Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden
    EMBO J 26:4535-45. 2007
    ..Furthermore, the data demonstrate that a nuclear hormone receptor affecting sympathetic signaling can override its autonomous effects in peripheral tissues...
  93. doi NeuroD1 regulates expression of thyroid hormone receptor 2 and cone opsins in the developing mouse retina
    Hong Liu
    Clinical Endocrinology Branch, National Institute of Diabetes and Digestive and Kidney Diseases National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 28:749-56. 2008
    ..These results thus connect the proneural pathway with opsin selection to ensure correct cone patterning during retinal development...
  94. pmc A comprehensive negative regulatory program controlled by Brn3b to ensure ganglion cell specification from multipotential retinal precursors
    Feng Qiu
    Center for Advanced Biotechnology and Medicine and Department of Pediatrics, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, New Jersey 08854, USA
    J Neurosci 28:3392-403. 2008
    ..Our data suggest that Brn3b specifies the RGC fate from multipotential precursors not only by promoting RGC differentiation but also by suppressing non-RGC differentiation programs as a safeguard mechanism...
  95. pmc Cardioselective dominant-negative thyroid hormone receptor (Delta337T) modulates myocardial metabolism and contractile efficiency
    Outi M Hyyti
    Children s Hospital and Regional Medical Center MSW 4841, 4800 Sand Point Way NE, Seattle, WA 98105, USA
    Am J Physiol Endocrinol Metab 295:E420-7. 2008
    ..Some of these changes are heart rate dependent, indicating that the substrate shift may represent an accommodation to altered contractile protein kinetics, which can be disrupted by pacing stress...
  96. pmc PTEN deficiency accelerates tumour progression in a mouse model of thyroid cancer
    C J Guigon
    Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA
    Oncogene 28:509-17. 2009
    ..Mice harbouring a dominant-negative mutant thyroid hormone receptor beta (TRbeta(PV/PV) mice) spontaneously develop follicular thyroid carcinoma and distant metastases similar ..
  97. pmc Dual requirement for Pax6 in retinal progenitor cells
    Varda Oron-Karni
    Sackler Faculty of Medicine, Human Molecular Genetics and Biochemistry, Tel Aviv University, Ramat Aviv 69978, Tel Aviv, Israel
    Development 135:4037-47. 2008
    ..Together, these data suggest an intricate dual role for Pax6 in retinal neurogenesis, while pointing to the cryptic divergence of RPCs into distinct progenitor pools...
  98. pmc Thyroid hormone receptor-beta is associated with coronary angiogenesis during pathological cardiac hypertrophy
    Ayako Makino
    Department of Medicine, Division of Endocrinology and Metabolism, University of California, San Diego, La Jolla, California 92093 0618, USA
    Endocrinology 150:2008-15. 2009
    ..These data suggest that TRbeta in the coronary ECs regulates capillary density during cardiac development, and down-regulation of TRbeta results in coronary microvascular rarefaction during pathological hypertrophy...
  99. doi The skeletal phenotypes of TRalpha and TRbeta mutant mice
    J H Duncan Bassett
    Molecular Endocrinology Group, Division of Medicine, Imperial College London, MRC Clinical Sciences Centre, Hammersmith Hospital, London, UK
    J Mol Endocrinol 42:269-82. 2009
    ..Detailed future analysis of the molecular mechanisms of T(3) action in bone will enhance our understanding of this emerging field and has the potential to identify novel strategies for the prevention and treatment of osteoporosis...
  100. pmc Deafness in TRbeta mutants is caused by malformation of the tectorial membrane
    Harald Winter
    Department of Otorhinolaryngology, Tübingen Hearing Research Center, University of Tubingen, 72076 Tubingen, Germany
    J Neurosci 29:2581-7. 2009
    b>Thyroid hormone receptor beta (TRbeta) dysfunction leads to deafness in humans and mice...

Research Grants10

  1. Human Retinal Progenitor Cells
    Meredithe Applebury; Fiscal Year: 2004
    ..abstract_text> ..
  2. Thyroid Hormone Receptor Isoforms & Coactivators In Vivo
    Roy Weiss; Fiscal Year: 2005
    ..Such information would generate important leads in understanding the specific mechanistic aspects of TH action. ..
  3. Nuclear cofactors in Human Thyroid Disease
    Roy Weiss; Fiscal Year: 2007
    ..3) Determine the cause for hypersensitivity to TH. This will allow clinicians to better identify factors influencing thyroid function. ..
  4. THYROID ACTION IN THE HEART
    Wolfgang Dillmann; Fiscal Year: 2006
    ..TR) knockout (KO) mice indicate that TR alpha KO mice have decreased contractile function and heart rate but TR beta KO mice have normal cardiac function...
  5. Targeting Antioxidant Therapy to Cardiac Mitochondria
    EVAN ABEL; Fiscal Year: 2006
    ..Once efficacy is determined, promising reagents can then be subjected to pharmacokinetic and toxicological analysis following systemic administration. ..
  6. Insulin Signaling and the Heart in Diabetes
    EVAN ABEL; Fiscal Year: 2007
    ..These studies will shed important insight into the regulation of cardiac function and metabolism by insulin and the role of impaired insulin signaling in the pathogenesis of diabetic cardiomyopathy. [unreadable] [unreadable]..
  7. Heart Failure and Thyroid Hormone
    Wolfgang H Dillmann; Fiscal Year: 2010
    ..findings indicate that altering TR action in CH/HF markedly influences fatty acid oxidation, exerted through a TR beta specific mechanism...
  8. Insulin resistance and cardiac dysfunction in obesity
    EVAN ABEL; Fiscal Year: 2007
    ..These studies will provide a detailed and comprehensive analysis of the role that abnormal myocardial insulin signaling plays in the pathogenesis of cardiac dysfunction in obesity. ..
  9. CARDIAC ISCHEMIA AND HSPS
    Wolfgang Dillmann; Fiscal Year: 2008
    ..Results obtained from these investigations of protective effects of specific HSPs against Ism-Reper induced myocardial injury may lead in the future to new treatment strategies for ischemic heartdisease. ..
  10. CARDIAC HYPERTROPHY AND SERCA2 GENE EXPRESSION
    Wolfgang Dillmann; Fiscal Year: 2008
    ..In addition, we will determine if HF induces changes in Mito Ca handling is correlated with diminished high-energy phosphate production and can be reverted towards normal. [unreadable] [unreadable] [unreadable] [unreadable]..