Tgfb1

Summary

Gene Symbol: Tgfb1
Description: transforming growth factor, beta 1
Alias: TGF-beta1, TGFbeta1, Tgfb, Tgfb-1, transforming growth factor beta-1
Species: mouse

Top Publications

  1. doi Brain area-specific effect of TGF-beta signaling on Wnt-dependent neural stem cell expansion
    Sven Falk
    Institute of Cell Biology, ETH Honggerberg, CH 8093 Zurich, Switzerland
    Cell Stem Cell 2:472-83. 2008
  2. ncbi T cell-produced transforming growth factor-beta1 controls T cell tolerance and regulates Th1- and Th17-cell differentiation
    Ming O Li
    Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Immunity 26:579-91. 2007
  3. pmc Transcriptional regulation of SM22alpha by Wnt3a: convergence with TGFbeta(1)/Smad signaling at a novel regulatory element
    Shawn L Shafer
    Washington University School of Medicine, Center for Cardiovascular Research, Internal Medicine BMD, Campus Box 8301, 660 South Euclid Ave, St Louis, MO 63110, USA
    J Mol Cell Cardiol 46:621-35. 2009
  4. ncbi Mesenchymal-epithelial interactions and transforming growth factor-beta expression during mouse prostate morphogenesis
    T L Timme
    Scott Department of Urology, Baylor College of Medicine, Houston, Texas 77030
    Endocrinology 134:1039-45. 1994
  5. ncbi Autoimmune manifestations in the transforming growth factor-beta 1 knockout mouse
    L Yaswen
    Molecular and Medical Genetics Section, National Institute of Neurological Disorders and Stroke, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 87:1439-45. 1996
  6. ncbi Transforming growth factor-beta controls development, homeostasis, and tolerance of T cells by regulatory T cell-dependent and -independent mechanisms
    Ming O Li
    Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Immunity 25:455-71. 2006
  7. ncbi Transforming growth factor-beta induces development of the T(H)17 lineage
    Paul R Mangan
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294 2170, USA
    Nature 441:231-4. 2006
  8. ncbi TGF-beta signalling from cell membrane to nucleus through SMAD proteins
    C H Heldin
    Ludwig Institute for Cancer Research, Biomedical Centre, Uppsala, Sweden
    Nature 390:465-71. 1997
  9. ncbi TGF-beta signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia
    Neil A Bhowmick
    Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Science 303:848-51. 2004
  10. doi TGF-beta is required to maintain the pool of immature Langerhans cells in the epidermis
    Junda M Kel
    Department of Immunology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
    J Immunol 185:3248-55. 2010

Research Grants

Detail Information

Publications204 found, 100 shown here

  1. doi Brain area-specific effect of TGF-beta signaling on Wnt-dependent neural stem cell expansion
    Sven Falk
    Institute of Cell Biology, ETH Honggerberg, CH 8093 Zurich, Switzerland
    Cell Stem Cell 2:472-83. 2008
    ..Thus, TGF-beta signaling controls the size of a specific brain area, the dorsal midbrain, by antagonizing canonical Wnt signaling and negatively regulating self-renewal of neuroepithelial stem cells...
  2. ncbi T cell-produced transforming growth factor-beta1 controls T cell tolerance and regulates Th1- and Th17-cell differentiation
    Ming O Li
    Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Immunity 26:579-91. 2007
    ..Here, we show that mice with a T cell-specific deletion of the Tgfb1 gene developed lethal immunopathology in multiple organs, and this development was associated with enhanced T cell ..
  3. pmc Transcriptional regulation of SM22alpha by Wnt3a: convergence with TGFbeta(1)/Smad signaling at a novel regulatory element
    Shawn L Shafer
    Washington University School of Medicine, Center for Cardiovascular Research, Internal Medicine BMD, Campus Box 8301, 660 South Euclid Ave, St Louis, MO 63110, USA
    J Mol Cell Cardiol 46:621-35. 2009
    ..RNAi "knockdown" of beta-catenin inhibited Wnt3a induction of SM22alpha. Thus, Wnt/beta-catenin signaling interacts with TGFbeta/Smad pathways to control SM22alpha gene transcription...
  4. ncbi Mesenchymal-epithelial interactions and transforming growth factor-beta expression during mouse prostate morphogenesis
    T L Timme
    Scott Department of Urology, Baylor College of Medicine, Houston, Texas 77030
    Endocrinology 134:1039-45. 1994
    ....
  5. ncbi Autoimmune manifestations in the transforming growth factor-beta 1 knockout mouse
    L Yaswen
    Molecular and Medical Genetics Section, National Institute of Neurological Disorders and Stroke, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 87:1439-45. 1996
    ..Our results describe autoimmune activity that ensues when the TGF-beta 1 cytokine is absent...
  6. ncbi Transforming growth factor-beta controls development, homeostasis, and tolerance of T cells by regulatory T cell-dependent and -independent mechanisms
    Ming O Li
    Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Immunity 25:455-71. 2006
    ..This study reveals pleiotropic functions of TGF-beta signaling in T cells that may ensure a diverse and self-tolerant T cell repertoire in vivo...
  7. ncbi Transforming growth factor-beta induces development of the T(H)17 lineage
    Paul R Mangan
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294 2170, USA
    Nature 441:231-4. 2006
    ..The action of TGF-beta on naive T cells is antagonized by interferon-gamma and IL-4, thus providing a mechanism for divergence of the T(H)1, T(H)2 and T(H)17 lineages...
  8. ncbi TGF-beta signalling from cell membrane to nucleus through SMAD proteins
    C H Heldin
    Ludwig Institute for Cancer Research, Biomedical Centre, Uppsala, Sweden
    Nature 390:465-71. 1997
    ..Inhibitory SMADs have been identified that block the activation of these pathway-restricted SMADs...
  9. ncbi TGF-beta signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia
    Neil A Bhowmick
    Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Science 303:848-51. 2004
    ..Thus, TGF-beta signaling in fibroblasts modulates the growth and oncogenic potential of adjacent epithelia in selected tissues...
  10. doi TGF-beta is required to maintain the pool of immature Langerhans cells in the epidermis
    Junda M Kel
    Department of Immunology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
    J Immunol 185:3248-55. 2010
    ..In conclusion, TGF-beta inhibits in vivo LC maturation and migratory phenotype, identifying TGF-beta as a critical factor controlling LC homeostasis in the steady state...
  11. ncbi Characterization of latent TGF-beta activation by murine peritoneal macrophages
    I Nunes
    Department of Cell Biology, New York University Medical Center, New York 10016, USA
    J Immunol 155:1450-9. 1995
    ..TGF-beta formed within the initial 24 h modulated the plasminogen activator system by down-regulating uPA, suggesting that TGF-beta temporally modulated its own formation by regulating cell-associated uPA...
  12. ncbi The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms
    D M Kingsley
    Department of Developmental Biology, Stanford University, California 94305 5427
    Genes Dev 8:133-46. 1994
  13. ncbi Dysregulation of TGF-beta activation contributes to pathogenesis in Marfan syndrome
    Enid R Neptune
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nat Genet 33:407-11. 2003
    ..These data indicate that matrix sequestration of cytokines is crucial to their regulated activation and signaling and that perturbation of this function can contribute to the pathogenesis of disease...
  14. pmc TGF-beta1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory T cells
    Julien C Marie
    Department of Immunology, University of Washington, Seattle, WA 98195, USA
    J Exp Med 201:1061-7. 2005
    ..Thus, our results establish an essential link between TGF-beta1 signaling in peripheral T reg cells and T reg cell maintenance in vivo...
  15. ncbi Activity-dependent release of transforming growth factor-beta in a neuronal network in vitro
    A Lacmann
    Department of Neuroanatomy, Center for Anatomy, Georg August University Gottingen, Kreuzbergring 36, D 37075 Gottingen, Germany
    Neuroscience 150:647-57. 2007
    ..Together, these results suggest an activity-dependent release and gene transcription of TGF-beta from mouse hippocampal neurons in vitro as well as subsequent autocrine functions of the released TGF-beta within the hippocampal network...
  16. pmc Tgf-Beta isoform specific regulation of airway inflammation and remodelling in a murine model of asthma
    Stephen E Bottoms
    Lung Pathobiology Group, Centre for Respiratory Research, University College London, London, United Kingdom
    PLoS ONE 5:e9674. 2010
    ....
  17. pmc Heart and liver defects and reduced transforming growth factor beta2 sensitivity in transforming growth factor beta type III receptor-deficient embryos
    Kaye L Stenvers
    Ludwig Institute for Cancer Research, Royal Melbourne Hospital, Victoria 3050, Australia
    Mol Cell Biol 23:4371-85. 2003
    ..These data indicate that TbetaRIII is an important modulator of TGFbeta2 function in embryonic fibroblasts and that reduced sensitivity to TGFbeta2 may underlie aspects of the TbetaRIII mutant phenotype...
  18. ncbi Mechanisms underlying TGF-beta1-induced expression of VEGF and Flk-1 in mouse macrophages and their implications for angiogenesis
    Seong Hyun Jeon
    Department of Molecular Bioscience, School of Bioscience and Biotechnology, Kangwon National University, Chunchon, Korea
    J Leukoc Biol 81:557-66. 2007
    ..The results from the present study indicate that TGF-beta1 can activate mouse macrophages to express angiogenic mediators such as VEGF, MMP-9, and Flk-1...
  19. doi Smad2 and Smad3 are redundantly essential for the TGF-beta-mediated regulation of regulatory T plasticity and Th1 development
    Tomohito Takimoto
    Department of Microbiology and Immunology, Keio University School of Medicine, Shinjyuku ku, Tokyo, Japan
    J Immunol 185:842-55. 2010
    ..However, TGF-beta-mediated induction of RORgamma t, a master regulator of Th17 cell, was independent of both Smad2 and Smad3, suggesting that TGF-beta regulates Th17 development through Smad2/3-dependent and -independent mechanisms...
  20. ncbi B cells activated by lipopolysaccharide, but not by anti-Ig and anti-CD40 antibody, induce anergy in CD8+ T cells: role of TGF-beta 1
    Vrajesh V Parekh
    National Center for Cell Science, Pune, Maharashtra, India School of Biotechnology, Devi Ahilya Vishwavidyalaya, Indore, Madhya Pradesh, India
    J Immunol 170:5897-911. 2003
    ..Therefore, this study, for the first time, provides a novel mechanism of B cell surface TGF-beta1-mediated hyporesponsiveness leading to anergy of CD8(+) T cells...
  21. ncbi Naturally occurring lung CD4(+)CD25(+) T cell regulation of airway allergic responses depends on IL-10 induction of TGF-beta
    Anthony Joetham
    Department of Pediatrics, Division of Cell Biology, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Immunol 178:1433-42. 2007
    ..By analogy, anti-TGF-beta treatment reduced regulatory T cell activity. These data identify naturally occurring lung CD4(+)CD25(+) T cells as capable of regulating lung allergic responses in an IL-10- and TGF-beta-dependent manner...
  22. ncbi TGF-beta1/SMAD signaling induces astrocyte fate commitment in vitro: implications for radial glia development
    Joice Stipursky
    Departamento de Anatomia, Instituto de Ciencias Biomedicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
    Glia 55:1023-33. 2007
    ..neurons activate the promoter of the astrocyte maturation marker GFAP in astrocytes by secretion of transforming growth factor beta 1 (TGF-beta1) in vitro...
  23. ncbi Transforming growth factor-beta expression and natural killer cell responses during virus infection of normal, nude, and SCID mice
    H C Su
    Division of Biology and Medicine, Brown University, Providence, RI 02912
    J Immunol 151:4874-90. 1993
    ..Treatment with active TGF-beta 1 reduced the numbers of NK cells per spleen in infected nude mice to the levels found in infected littermate controls.(ABSTRACT TRUNCATED AT 400 WORDS)..
  24. pmc A role for TGFbeta1 in langerhans cell biology. Further characterization of the epidermal Langerhans cell defect in TGFbeta1 null mice
    T A Borkowski
    Dermatology Branch, National Cancer Institute, Bethesda, Maryland 20892, USA
    J Clin Invest 100:575-81. 1997
    Previous studies of TGFbeta1 null (-/-) mice indicated that the epidermis was devoid of Langerhans cells (LC) and that the LC deficiency was not secondary to the inflammation that is the dominant feature of the -/- phenotype (Borkowski, T...
  25. pmc A role for TGFbeta signaling in the pathogenesis of psoriasis
    Gangwen Han
    Department of Pathology, University of Colorado Denver, Aurora, Colorado 80045, USA
    J Invest Dermatol 130:371-7. 2010
    ..Our recent study using a keratin 5 promoter (K5.TGFbeta1(wt)) showed that transgenic mice expressing wild-type TGFbeta1 in the epidermis developed severe skin ..
  26. pmc Transforming growth factor-beta signaling curbs thymic negative selection promoting regulatory T cell development
    Weiming Ouyang
    Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Immunity 32:642-53. 2010
    ..These findings reveal a critical function for TGF-beta in control of autoreactive T cell fates with important implications for understanding T cell self-tolerance mechanisms...
  27. ncbi CD28 disruption exacerbates inflammation in Tgf-beta1-/- mice: in vivo suppression by CD4+CD25+ regulatory T cells independent of autocrine TGF-beta1
    Mizuko Mamura
    Laboratory of Cell Regulation and Carcinogenesis, National Cancer Institute, National Institutes of Health, Bldg 41, 41 Library Drive MSC 5055, Bethesda, MD 20892 5055, USA
    Blood 103:4594-601. 2004
    ....
  28. ncbi Coexpression of TGF-beta1 and IL-10 enables regulatory T cells to completely suppress airway hyperreactivity
    Katrin Presser
    Department of Medicine, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    J Immunol 181:7751-8. 2008
    ..In conclusion, modulation of cytokine expression by Treg may have therapeutic potential for the treatment of AHR in asthma. The mechanisms of the effects of Treg on airway inflammation require further clarification...
  29. pmc Modulation of TGF-β signaling by endoglin in murine hemangioblast development and primitive hematopoiesis
    Liying Zhang
    Department of Medicine, Lillehei Heart Institute, University of Minnesota, Minneapolis, MN, USA
    Blood 118:88-97. 2011
    ..We propose that endoglin regulates primitive hematopoiesis by modulating the activity of the Smad1/5 signaling pathway in early stages of development...
  30. doi Transforming growth factor-beta regulates house dust mite-induced allergic airway inflammation but not airway remodeling
    Ramzi Fattouh
    Department of Pathology and Molecular Medicine, Head, Division of Respiratory Diseases and Allergy, MDCL 4013, McMaster University, 1200 Main Street West, Hamilton, ON, Canada
    Am J Respir Crit Care Med 177:593-603. 2008
    ..Transforming growth factor (TGF)-beta is a powerful regulator of both the tissue repair and inflammatory responses, and numerous experimental and clinical studies suggest that it may play an integral role in the pathogenesis of asthma...
  31. ncbi Thrombospondin-1 is a major activator of TGF-beta1 in vivo
    S E Crawford
    Robert H Lurie Cancer Center, Department of Pathology, Northwestern University Medical School, Chicago, Illinois 60611, USA
    Cell 93:1159-70. 1998
    ....
  32. pmc IL-23 promotes the production of IL-17 by antigen-specific CD8 T cells in the absence of IL-12 and type-I interferons
    Meredith M Curtis
    Department of Immunology, University of Washington School of Medicine, Seattle, 98195, USA
    J Immunol 183:381-7. 2009
    ..Thus, CD8 T cells retain sufficient plasticity to respond to environmental cues and can acquire additional effector functions in response to their environmental context...
  33. pmc Arkadia amplifies TGF-beta superfamily signalling through degradation of Smad7
    Daizo Koinuma
    Department of Biochemistry, the Cancer Institute of the Japanese Foundation for Cancer Research JFCR, Toshima ku, Tokyo, Japan
    EMBO J 22:6458-70. 2003
    ..Arkadia may thus play an important role as an amplifier of TGF-beta superfamily signalling under both physiological and pathological conditions...
  34. pmc Disruption of LTBP-4 function reduces TGF-beta activation and enhances BMP-4 signaling in the lung
    Katri Koli
    Department of Virology, Haartman Institute and Helsinki University Hospital, University of Helsinki, 00014 Helsinki, Finland
    J Cell Biol 167:123-33. 2004
    ..Treatment with active TGF-beta1 rescued BMP-4 and gremlin expression to wild-type levels. Our results indicate that the lack of LTBP-4-mediated targeting and activation of TGF-beta1 leads to enhanced BMP-4 signaling in mouse lung...
  35. ncbi Transforming growth factor-beta1 is a new form of tumor suppressor with true haploid insufficiency
    B Tang
    Laboratory of Cell Regulation and Carcinogenesis formerly Laboratory of Chemoprevention, National Cancer Institute, Bethesda, Maryland 20892 5055, USA
    Nat Med 4:802-7. 1998
    ....
  36. pmc Disruption of the gene encoding the latent transforming growth factor-beta binding protein 4 (LTBP-4) causes abnormal lung development, cardiomyopathy, and colorectal cancer
    Anja Sterner-Kock
    Laboratory for Molecular Hematology, University of Frankfurt Medical School, 60596 Frankfurt am Main, Germany
    Genes Dev 16:2264-73. 2002
    ..This phenotype supports the predicted dual role of LTBP-4 as a structural component of the extracellular matrix and as a local regulator of TGF-beta tissue deposition and signaling...
  37. ncbi Immune dysregulation in TGF-beta 1-deficient mice
    M Christ
    Cellular Immunology Section, Laboratory of Immunology, National Institute of Dental Research, National Institutes of Health, Bethesda, MD 20892
    J Immunol 153:1936-46. 1994
    ..The mechanism leading to T cell anergy remains unclear; however, these data confirm the essential role for TGF-beta 1 in maintaining normal immune function...
  38. pmc Interleukin-12 (IL-12) and IL-23 induction of substance p synthesis in murine T cells and macrophages is subject to IL-10 and transforming growth factor beta regulation
    Arthur Blum
    Division of Gastroenterology 233, Tufts New England Medical Center, Boston, MA 02111, USA
    Infect Immun 76:3651-6. 2008
    ..Hemokinin is another tachykinin with homology to substance P. Macrophages and T cells make hemokinin, but hemokinin production is not subject to IL-12 or IL-23 regulation...
  39. doi The gep oncogenes, Galpha(12) and Galpha(13), upregulate the transforming growth factor-beta1 gene
    S J Lee
    Innovative Drug Research Center for Metabolic and Inflammatory Disease, College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Kwanak gu, Seoul, Korea
    Oncogene 28:1230-40. 2009
    Transforming growth factor-beta1 (TGFbeta1) plays a role in neoplastic transformation and transdifferentiation. Galpha(12) and Galpha(13), referred to as the gep oncogenes, stimulate mitogenic pathways...
  40. pmc TGF-beta/Smad3 signals repress chondrocyte hypertrophic differentiation and are required for maintaining articular cartilage
    X Yang
    Genetics of Development and Disease Branch, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Cell Biol 153:35-46. 2001
    ..Without these inhibition signals, chondrocytes break quiescent state and undergo abnormal terminal differentiation, ultimately leading to osteoarthritis...
  41. pmc TGF-beta inhibits muscle differentiation through functional repression of myogenic transcription factors by Smad3
    D Liu
    Department of Growth and Development, University of California at San Francisco, 94143, USA
    Genes Dev 15:2950-66. 2001
    ..Together, these results reveal a model for how TGF-beta, through Smad3-mediated transcriptional repression, inhibits myogenic differentiation...
  42. ncbi Disruption of anterior segment development by TGF-beta1 overexpression in the eyes of transgenic mice
    Cassandra Flügel-Koch
    Department of Anatomy, Molecular Anatomy and Embryology, University of Erlangen Nurnberg, Erlangen, Germany
    Dev Dyn 225:111-25. 2002
    ....
  43. ncbi The TGF-beta response to Leishmania chagasi in the absence of IL-12
    Mary E Wilson
    Veterans Affairs Medical Center, Department of Internal Medicine, University of Iowa, Iowa City 52242, USA
    Eur J Immunol 32:3556-65. 2002
    ..chagasi has an inherent propensity to elicit a prominent TGF-beta response that either suppresses, or is suppressed by, a type 1 response. We propose this be termed a "type 3" immune response, which can antagonize a type 1 response...
  44. pmc Endogenous TGF-beta signaling suppresses maturation of osteoblastic mesenchymal cells
    Shingo Maeda
    Department of Biochemistry, The Cancer Institute of the Japanese Foundation for Cancer Research, Tokyo
    EMBO J 23:552-63. 2004
    ....
  45. pmc Overexpression of cathepsin K during silica-induced lung fibrosis and control by TGF-beta
    Sybille van den Brule
    Universite Catholique de Louvain, Clos Chapelle aux Champs, 30 54, 1200 Brussels, Brussels, Belgium
    Respir Res 6:84. 2005
    ..To examine whether cathepsin(s) (Cat) are important in the development of pulmonary fibrosis, we assessed the expression of four Cat known for their collagenolytic activity in a model of silica-induced lung fibrosis...
  46. ncbi Emilin1 links TGF-beta maturation to blood pressure homeostasis
    Luca Zacchigna
    Developmental Signaling Laboratory, Department of Histology Microbiology and Medical Biotechnologies, University of Padua, viale Colombo 3, 35121 Padua, Italy
    Cell 124:929-42. 2006
    ..This study highlights the importance of modulation of TGF-beta availability in the pathogenesis of hypertension...
  47. ncbi Suppression of atherogenesis by delivery of TGFbeta1ACT using adeno-associated virus type 2 in LDLR knockout mice
    Dayuan Li
    Gene Therapy Program, Division of Cardiovascular Medicine, University of Arkansas for Medical Sciences, VA Medical Center, Little Rock, AR 72205, USA
    Biochem Biophys Res Commun 344:701-7. 2006
    ..These findings suggest a novel view of TGFbeta(1) in atherogenesis and a potential new gene therapy for treatment of atherosclerosis...
  48. pmc Autophagy promotes intracellular degradation of type I collagen induced by transforming growth factor (TGF)-β1
    Sung Il Kim
    Renal Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 287:11677-88. 2012
    ..Our findings suggest a novel role of autophagy as a cytoprotective mechanism to negatively regulate and prevent excess collagen accumulation in the kidney...
  49. ncbi The TGF-beta2 isoform is both a required and sufficient inducer of murine hair follicle morphogenesis
    K Foitzik
    Cutaneous Biology Research Center, Massachussetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, 02129, USA
    Dev Biol 212:278-89. 1999
    ..Thus, the TGF-beta2 isoform plays a specific role, not shared by the other TGF-beta isoforms, as an inducer of hair follicle morphogenesis and is both required and sufficient to promote this process...
  50. ncbi Transforming growth factor beta and atherosclerosis: so far, so good for the protective cytokine hypothesis
    David J Grainger
    Department of Medicine, University of Cambridge, Box 157, Addenbrooke s Hospital, Cambridge, CB2 2QQ, UK
    Arterioscler Thromb Vasc Biol 24:399-404. 2004
    ..First, is the role of TGF-beta in vascular biology similar in humans and in mice? Secondly, how important, compared with defects in thrombosis or lipoprotein metabolism, is the protective role of TGF-beta during atherogenesis?..
  51. ncbi TGF-beta 1 plays an important role in the mechanism of CD4+CD25+ regulatory T cell activity in both humans and mice
    Kazuhiko Nakamura
    Mucosal Immunity Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 10, Room 11N238, 10 Center Drive, Bethesda, MD 20892, USA
    J Immunol 172:834-42. 2004
    ..Together, these studies demonstrate that TGF-beta1 produced by CD4+CD25+ T cells is involved in the suppressor activity of these cells, particularly in their ability to regulate intestinal inflammation...
  52. ncbi Cell intrinsic TGF-beta 1 regulation of B cells
    Marilyn J Gros
    Aix Marseille Universite, Faculte des Sciences de Luminy, Centre d immunologie de Marseille Luminy, Institut National de la Santé et de la Recherche Médicale U631, Marseille, France
    J Immunol 180:8153-8. 2008
    ..The analysis of T cell-deficient, TGF-beta1 knockout mice and the production of chimeras in which B but not T cells lacked TGF-beta1 allowed us to show that B cells are controlled in part by cell autonomous production of TGF-beta1...
  53. pmc Hepatic expression of mature transforming growth factor beta 1 in transgenic mice results in multiple tissue lesions
    N Sanderson
    Laboratory of Experimental Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 92:2572-6. 1995
    Aberrant expression of transforming growth factor beta 1 (TGF-beta 1) has been implicated in a number of disease processes, particularly those involving fibrotic and inflammatory lesions...
  54. ncbi The effects of retinoid status on TGF beta expression during mouse embryogenesis
    R Mahmood
    Laboratory of Chemoprevention, National Institutes of Health, Bethesda, MD 20892, USA
    Anat Embryol (Berl) 192:21-33. 1995
    ..The long-term nature of the effects of transient exposure to RA excess suggests that the mechanisms of RA-TGF beta interaction may be indirect...
  55. ncbi Interactions between the transforming growth factor beta (TGF beta) and retinoic acid signal transduction pathways in murine embryonic palatal cells
    P Nugent
    Department of Anatomy and Developmental Biology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107
    Differentiation 58:149-55. 1994
    ..These data constitute the first demonstration of an effect of TGF-beta on the expression of CRABP-I and CRABP-II and provide further evidence for cross-talk between RA and TGF-beta signal transduction pathways...
  56. pmc TGF-β induces surface LAP expression on murine CD4 T cells independent of Foxp3 induction
    Takatoku Oida
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    PLoS ONE 5:e15523. 2010
    ..Murine CD4 Foxp3(+) Tregs have also been reported to express surface LAP, but these studies have been hampered by the lack of suitable anti-mouse LAP mAbs...
  57. pmc Conditional epidermal expression of TGFbeta 1 blocks neonatal lethality but causes a reversible hyperplasia and alopecia
    X Liu
    Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Cancer Institute, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 98:9139-44. 2001
    To study the role of transforming growth factor type beta1 (TGFbeta1) in epidermal growth control and disease, we have generated a conditional expression system by using the bovine keratin 5 promoter to drive expression of the ..
  58. ncbi Embryonic gene expression patterns of TGF beta 1, beta 2 and beta 3 suggest different developmental functions in vivo
    F A Millan
    Duncan Guthrie Institute of Medical Genetics, University of Glasgow, UK
    Development 111:131-43. 1991
    ..Finally both TGF beta 1 and beta 2 transcripts are seen in regions actively undergoing cardiac septation and valve formation, suggesting some interaction of these growth factors in this developmental process...
  59. pmc Transforming Growth Factor {beta} Can Stimulate Smad1 Phosphorylation Independently of Bone Morphogenic Protein Receptors
    Katharine H Wrighton
    Michael E DeBakey Department of Surgery and Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 284:9755-63. 2009
    ..Thus, TGFbeta-mediated Smad1 phosphorylation appears to occur via different receptor complexes in a cell type-specific manner...
  60. pmc Transforming growth factor-beta 3 is required for secondary palate fusion
    G Proetzel
    Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Ohio 45267, USA
    Nat Genet 11:409-14. 1995
    ..No craniofacial abnormalities were observed. This result demonstrates that TGF-beta 3 affects palatal shelf fusion by an intrinsic, primary mechanism rather than by effects secondary to craniofacial defects...
  61. ncbi RNA and protein localisations of TGF beta 2 in the early mouse embryo suggest an involvement in cardiac development
    M C Dickson
    Department of Medical Genetics, Glasgow University, Yorkhill, UK
    Development 117:625-39. 1993
    ..5 days post coitum. The results are discussed in terms of a potential role of TGF beta 2 in controlling cardiomyogenesis and in inductive interactions leading to cardiac cushion tissue formation...
  62. ncbi TGF-beta 1 influences the relative development of the exocrine and endocrine pancreas in vitro
    F Sanvito
    Department of Morphology, University of Geneva Medical School, Switzerland
    Development 120:3451-62. 1994
    ..More generally, they are compatible with the notion that, during organogenesis, cytokines act as paracrine factors responsible for the development and maintenance of appropriate proportions of different tissue constituents...
  63. ncbi Maternal rescue of transforming growth factor-beta 1 null mice
    J J Letterio
    Laboratory of Chemoprevention, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892
    Science 264:1936-8. 1994
    ..These results suggest an important role for maternal sources of TGF-beta 1 during development and, more generally, provide evidence for maternal rescue of targeted gene disruption in the fetus...
  64. pmc Transforming growth factor beta 1 (TGF-beta 1) controls expression of major histocompatibility genes in the postnatal mouse: aberrant histocompatibility antigen expression in the pathogenesis of the TGF-beta 1 null mouse phenotype
    A G Geiser
    Laboratory of Chemoprevention, National Cancer Institute, Bethesda, MD 20892
    Proc Natl Acad Sci U S A 90:9944-8. 1993
    The phenotype of the transforming growth factor beta 1 (TGF-beta 1) null mouse has been previously described and is characterized by inflammatory infiltrates in multiple organs leading to a wasting syndrome and death as early as 3 weeks ..
  65. ncbi TGF-beta 1 overexpression in murine pancreas induces chronic pancreatitis and, together with TNF-alpha, triggers insulin-dependent diabetes
    F Sanvito
    Département de Morphologie, Centre Medical Universitaire, Geneve 4, Switzerland
    Biochem Biophys Res Commun 217:1279-86. 1995
    ....
  66. pmc Spontaneously increased production of nitric oxide and aberrant expression of the inducible nitric oxide synthase in vivo in the transforming growth factor beta 1 null mouse
    Y Vodovotz
    Laboratory of Chemoprevention, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Exp Med 183:2337-42. 1996
    b>Transforming growth factor beta 1 null mice (TGF-beta 1-/-) suffer from multifocal inflammation and die by 3-4 wk of age...
  67. ncbi Transforming growth factor beta is essential for spindle cell conversion of mouse skin carcinoma in vivo: implications for tumor invasion
    G Portella
    Department of Medical Oncology, Glasgow University, United Kingdom
    Cell Growth Differ 9:393-404. 1998
    ....
  68. ncbi TGF-beta1 alters APC preference, polarizing islet antigen responses toward a Th2 phenotype
    C King
    Department of Immunology, Scripps Research Institute, La Jolla, California 92037, USA
    Immunity 8:601-13. 1998
    ..This study describes a novel mechanism in which expression of TGF-beta1 in the context of self-antigen shifts APC preference, deviating T cell responses to a Th2 phenotype, preventing IDDM...
  69. pmc Engagement of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) induces transforming growth factor beta (TGF-beta) production by murine CD4(+) T cells
    W Chen
    Oral Infection and Immunity Branch, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Exp Med 188:1849-57. 1998
    ..CTLA-4, through TGF-beta, may serve as a counterbalance for CD28 costimulation of IL-2 and CD4(+) T cell activation...
  70. ncbi Genetic events and the role of TGF beta in epithelial tumour progression
    R J Akhurst
    Onyx Pharmaceuticals, Richmond, CA 94806, USA
    J Pathol 187:82-90. 1999
    ..It is this latter effect which may be clinically more significant, since many human tumours overexpress TGF beta, yet the majority still retain the intracellular signaling systems necessary for the cell to respond to this growth factor...
  71. ncbi TGF-beta1 promotes microglial amyloid-beta clearance and reduces plaque burden in transgenic mice
    T Wyss-Coray
    Gladstone Institute of Neurological Disease, University of California, San Francisco, California, USA
    Nat Med 7:612-8. 2001
    ..These results demonstrate that TGF-beta1 is an important modifier of amyloid deposition in vivo and indicate that TGF-beta1 might promote microglial processes that inhibit the accumulation of Abeta in the brain parenchyma...
  72. pmc CD4(+)CD25(+) regulatory T cells can mediate suppressor function in the absence of transforming growth factor beta1 production and responsiveness
    Ciriaco A Piccirillo
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 1892, USA
    J Exp Med 196:237-46. 2002
    ..Collectively, these results demonstrate that CD4(+)CD25(+) suppressor function can occur independently of TGF-beta1...
  73. ncbi Loss of integrin alpha(v)beta6-mediated TGF-beta activation causes Mmp12-dependent emphysema
    David G Morris
    Lung Biology Center, Department of Medicine, San Francisco General Hospital, San Francisco, California 94143, USA
    Nature 422:169-73. 2003
    ..Furthermore, we show that a functional alteration in the TGF-beta activation pathway affects susceptibility to this disease...
  74. ncbi TGF-beta 1 regulates lymphocyte homeostasis by preventing activation and subsequent apoptosis of peripheral lymphocytes
    Ramireddy Bommireddy
    Department of Molecular Genetics, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    J Immunol 170:4612-22. 2003
    ..Here we demonstrate that unlike wild-type splenic lymphocytes, those from Tgfb1(-/-) mice are hyporesponsive to receptor-mediated mitogenic stimulation, as evidenced by diminished proliferation ..
  75. ncbi TGF-beta-induced SOCS3 expression augments TNF-alpha-induced osteoclast formation
    Alison C Lovibond
    Department of Cellular Pathology, St George s Hospital Medical School, London SW17 0RE, UK
    Biochem Biophys Res Commun 309:762-7. 2003
    ..This suggests that TGF-beta-induced expression of SOCS3 may represent a crucial mechanism by which TGF-beta antagonizes specific anti-osteoclastic JAK/STAT signals, priming precursors for resorption rather than inflammatory functions...
  76. ncbi Cutting edge: TGF-beta induces a regulatory phenotype in CD4+CD25- T cells through Foxp3 induction and down-regulation of Smad7
    Massimo C Fantini
    Laboratory of Immunology, I Medical Clinic, Johannes Gutenberg University of Mainz, Mainz, Germany
    J Immunol 172:5149-53. 2004
    ..In summary, we demonstrate that TGF-beta induces a regulatory phenotype in CD4(+)CD25(-) T cells through the induction of Foxp3 and a positive autoregulatory loop of TGF-beta signaling due to the absence of Smad7...
  77. ncbi Reduced expression of transforming growth factor beta 1 exacerbates pathology in an experimental asthma model
    Wiebke Scherf
    Department of Pediatrics, Division of Allergy and Pulmonology, Martin Luther University Halle Wittenberg, D 06120 Halle, Germany
    Eur J Immunol 35:198-206. 2005
    ....
  78. pmc T cells that cannot respond to TGF-beta escape control by CD4(+)CD25(+) regulatory T cells
    Linda Fahlén
    Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, England, UK
    J Exp Med 201:737-46. 2005
    ..Importantly, the function of TGF-beta1(-/-) T reg cells was abrogated by anti-TGF-beta monoclonal antibody, indicating that functional TGF-beta can be provided by a non-T reg cell source...
  79. ncbi Manipulation of allergen-induced airway remodeling by treatment with anti-TGF-beta antibody: effect on the Smad signaling pathway
    Sarah J McMillan
    Leukocyte Biology Section, Division of Biomedical Sciences, Faculty of Medicine Imperial College, London, United Kingdom
    J Immunol 174:5774-80. 2005
    ..Moreover, the molecular mechanism behind this effect may involve regulation of active TGF-beta signaling...
  80. ncbi Transforming growth factor-beta2 enhances differentiation of cardiac myocytes from embryonic stem cells
    Dinender Kumar Singla
    Department of Medicine, University of Vermont, Burlington, VT 05446, USA
    Biochem Biophys Res Commun 332:135-41. 2005
    ..In conclusion, TGF-beta2 but not TGF-beta1, or -beta3 promotes cardiac myocyte differentiation from ES cells...
  81. ncbi IL-13 signaling through the IL-13alpha2 receptor is involved in induction of TGF-beta1 production and fibrosis
    Stefan Fichtner-Feigl
    Mucosal Immunity Section, Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 10 CRC 5W3864, 10 Center Drive, Bethesda, Maryland 20892, USA
    Nat Med 12:99-106. 2006
    ..signaling through IL-13Ralpha(2) to activate an AP-1 variant containing c-jun and Fra-2, which then activates the TGFB1 promoter...
  82. pmc Smad4 is required for maintaining normal murine postnatal bone homeostasis
    Xiaohong Tan
    Genetic Laboratory of Development and Disease, Institute of Biotechnology, Beijing 100071, PR China
    J Cell Sci 120:2162-70. 2007
    ..This correlated with reduced bone resorption possibly caused by downregulation of TGFbeta1 and alteration of the ligand receptor activator of NF-kappaB (RANKL)-osteoprotegerin (OPG) axis...
  83. doi Generation of mice with conditionally activated transforming growth factor beta signaling through the TbetaRI/ALK5 receptor
    Laurent Bartholin
    INSERM, U590, INSERM Avenirgroup, Oncogenèse et progression tumorale, Centre Leon Berard, 28 rue Laennec, Lyon Cedex 08, France
    Genesis 46:724-31. 2008
    ..In addition to the information provided on TGFbeta effects on T-cell biology, LSL-TbetaRI(CA) mouse constitutes an attractive tool to address the effect of TGFbeta signaling upregulation in any cell type expressing the cre-recombinase...
  84. pmc Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease
    M M Shull
    Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati College of Medicine, Ohio 45267 0524
    Nature 359:693-9. 1992
    ..TGF-beta 1-deficient mice may be valuable models for human immune and inflammatory disorders, including autoimmune diseases, transplant rejection and graft versus host reactions...
  85. ncbi Defective haematopoiesis and vasculogenesis in transforming growth factor-beta 1 knock out mice
    M C Dickson
    Department of Medical Genetics, University of Glasgow, Duncan Guthrie Institute, Yorkhill, UK
    Development 121:1845-54. 1995
    b>Transforming growth factor beta 1 (TGF beta 1) is shown here to be required for yolk sac haematopoiesis and endothelial differentiation...
  86. ncbi SLE-like autoantibodies and Sjögren's syndrome-like lymphoproliferation in TGF-beta knockout mice
    H Dang
    Audie L Murphy Memorial Veterans Hospital, San Antonio, Texas, USA
    J Immunol 155:3205-12. 1995
    ..Our results support the concept that TGF-beta 1 is an important naturally occurring immunosuppressive cytokine whose absence can lead to a systemic autoimmune disease...
  87. ncbi Targeted deletion of the TGF-beta 1 gene causes rapid progression to squamous cell carcinoma
    A B Glick
    Laboratory of Cellular Carcinogenesis and Tumor Promotion, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892
    Genes Dev 8:2429-40. 1994
    ..The lack of paracrine inhibition of tumor cell progression appears to result from the inability of tumor cells to localize host-derived TGF-beta 1 by a mechanism that operates in normal cells...
  88. pmc Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death
    A B Kulkarni
    Molecular Medical Genetics Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892
    Proc Natl Acad Sci U S A 90:770-4. 1993
    To delineate specific developmental roles of transforming growth factor beta 1 (TGF-beta 1) we have disrupted its cognate gene in mouse embryonic stem cells by homologous recombination to generate TGF-beta 1 null mice...
  89. pmc Early-onset multifocal inflammation in the transforming growth factor beta 1-null mouse is lymphocyte mediated
    R J Diebold
    Department of Molecular Genetics, University of Cincinnati College of Medicine, OH 45267, USA
    Proc Natl Acad Sci U S A 92:12215-9. 1995
    b>Transforming growth factor beta 1 (TGF beta 1)-null mice die fro complications due to an early-onset multifocal inflammatory disorder...
  90. ncbi Transforming growth factor-beta fails to inhibit allograft rejection or virus-induced autoimmune diabetes in transgenic mice
    M S Lee
    Department of Neuropharmacology, The Scripps research Insititute, La Jolla, California 92037, USA
    Transplantation 61:1112-5. 1996
    ..These results suggest that local TGF-beta1 does not serve as an immunosuppressive agent for allograft rejection or virus-mediated autoimmune diabetes...
  91. pmc Extracellular fibrillar structure of latent TGF beta binding protein-1: role in TGF beta-dependent endothelial-mesenchymal transformation during endocardial cushion tissue formation in mouse embryonic heart
    Y Nakajima
    Department of Anatomy, Saitama Medical School, Japan
    J Cell Biol 136:193-204. 1997
    ..These results suggest that LTBP-1 exists as an extracellular fibrillar structure and plays a role in the storage of TGF beta as a large latent TGF beta complex...
  92. pmc Lens-specific expression of transforming growth factor beta1 in transgenic mice causes anterior subcapsular cataracts
    Y Srinivasan
    Department of Cell Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    J Clin Invest 101:625-34. 1998
    ..The corneal opacities were associated with increased exfoliation of the squamous layer of the corneal epithelium and increased DNA replication in the basal epithelium...
  93. ncbi Phenotypic consequences of transforming growth factor beta1 gene ablation in murine embryonic fibroblasts: autocrine control of cell proliferation and extracellular matrix biosynthesis
    C Sudarshan
    Department of Biochemistry, College of Medicine, University of Tennessee, Memphis, USA
    J Cell Physiol 176:67-75. 1998
    ..Thus, our results are consistent with the hypothesis that TGF-beta1 acts as a negative autocrine regulator of growth and a positive autocrine regulator of ECM biosynthesis in embryonic fibroblasts...
  94. ncbi Decreased bone mass and bone elasticity in mice lacking the transforming growth factor-beta1 gene
    A G Geiser
    Endocrine Division of Lilly Research Labs, Eli Lilly and Company, Indianapolis, IN 46285, USA
    Bone 23:87-93. 1998
    ..These data show that longitudinal growth and total mineral content are affected in mice lacking TGF-beta1, as well as the elastic properties of the bone, consistent with an important role for TGF-beta1 in bone modeling and bone quality...
  95. ncbi Effects of TGF-beta on the immune system: implications for cancer immunotherapy
    K E de Visser
    Cancer Immunology Program, Cardinal Bernardin Cancer Center, Loyola University Chicago, Maywood, IL 60153, USA
    Leukemia 13:1188-99. 1999
    ....
  96. ncbi Myocardial fibrosis in transforming growth factor beta(1)heterozygous mice
    W W Brooks
    The Department of Veterans Affairs Medical Center, Boston, MA 02130, USA
    J Mol Cell Cardiol 32:187-95. 2000
    ..Thus, loss of one TGF- beta(1)allele appears to ameliorate age associated myocardial fibrosis and improve LV compliance, which may contribute to increased survival over the life span of these mice...
  97. ncbi Enhanced tumorigenesis and reduced transforming growth factor-beta type II receptor in lung tumors from mice with reduced gene dosage of transforming growth factor-beta1
    Y Kang
    Medicine Branch, National Cancer Institute, Rockville, Maryland 20850, USA
    Mol Carcinog 29:112-26. 2000
    ....
  98. pmc Requirement for transforming growth factor beta1 in controlling T cell apoptosis
    W Chen
    Cellular Immunology Section, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Exp Med 194:439-53. 2001
    ..These findings may have broad implications not only for T cell selection and death in immune responses and in the generation of tolerance, but also for defining the mechanisms of programmed cell death in general...
  99. ncbi Nuclear factor I-B (Nfib) deficient mice have severe lung hypoplasia
    Albert Gründer
    Institut fur Biologie III, Albert Ludwigs Universitat, Freiburg, Germany
    Mech Dev 112:69-77. 2002
    ..Heterozygotes do survive, but exhibit delayed pulmonary differentiation. Expression of transforming growth factor beta 1 (TGF-beta1) and sonic hedgehog (Shh) is not down-regulated in mutant lung epithelium at late stages ..
  100. pmc TGF-beta1 mediates the hypertrophic cardiomyocyte growth induced by angiotensin II
    Jo El J Schultz
    Department of Molecular Genetics, Biochemistry, and Microbiology, Cincinnati College of Medicine, 231 Albert Sabin Way, ML 0575, Cincinnati, OH 45267, USA
    J Clin Invest 109:787-96. 2002
    Angiotensin II (Ang II), a potent hypertrophic stimulus, causes significant increases in TGFb1 gene expression. However, it is not known whether there is a causal relationship between increased levels of TGF-beta1 and cardiac hypertrophy...
  101. ncbi Necroinflammatory liver disease in BALB/c background, TGF-beta 1-deficient mice requires CD4+ T cells
    Lynnie A Rudner
    Department of Pathology, Dartmouth Medical School, Lebanon, NH 03756, USA
    J Immunol 170:4785-92. 2003
    ..Furthermore, TGF-beta1 has a critical role in homeostatic regulation of the hepatic immune system, inhibiting the development or expansion of hepatic cytolytic CD4(+) T cells...

Research Grants35

  1. Glutathione deficiency & immune dysfunction during aging
    Rui Ming Liu; Fiscal Year: 2006
    ....
  2. Organ-specific migration of CD4+CD25+ regulatory T cells
    Chang Kim; Fiscal Year: 2006
    ..These studies have the potential to provide important information on organ or tissue-specific trafficking of CD4+CD25+ suppressor T cells and its impact on immune tolerance. ..
  3. Negative regulation of platelet activity
    DEBRA KAY NEWMAN; Fiscal Year: 2010
    ..We expect that information derived from this investigation has the potential to lead to improved diagnosis and treatment of bleeding disorders, myocardial infarction and stroke. ..
  4. Thymic Influence on Ocular Immunoregulation
    Robert E Cone; Fiscal Year: 2010
    ....
  5. Collaborative Development of a Vaccine against Cutaneous and Visceral Leishmanias
    MARY EDYTHE WILSON; Fiscal Year: 2010
    ..Through a coordinated approach in the three laboratories, we will systematically perform pre-clinical testing against several Leishmania species, with the goal of developing a pan-leishmania protective vaccine. ..
  6. ROLE OF TGF-B INDUCIBLE EARLY GENE IN OSTEOCLASTOGENESIS
    Merry Jo Oursler; Fiscal Year: 2010
    ..These studies will add to this knowledge and increase our understanding of osteoclast-mediated bone loss. Further, these studies should provide key information on the molecular mechanisms of osteoclast differentiation. ..
  7. Liver Biology, Development and Disease
    KLAUS KAESTNER; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  8. FUNCTIONAL GENOMICS OF THE BETA-CELL
    KLAUS KAESTNER; Fiscal Year: 2007
    ..The new resources generated through this project will be made available to the NIDDK-funded biotechnology centers and the diabetes research community at large. ..
  9. Specificity of Calcineurin Signaling in the Kidney
    JENNIFER GOOCH; Fiscal Year: 2007
    ..The goal of these experiments is to distinguish mechanisms of calcineurin-mediated regulation of ECM in glomeruli from calcineurin action that contributes to CsA-nephrotoxicity. ..
  10. TGF BETA Regulation of Osteoclast Apoptosis
    MERRY OURSLER; Fiscal Year: 2007
    ..Understanding osteoclast apoptosis regulation may provide important avenues for therapies to slow bone degradation during pathological bone loss. ..
  11. Isoform-specific inhibition of calcineurin to prevent nephrotoxicity
    JENNIFER GOOCH; Fiscal Year: 2007
    ..Using a well-characterized skin transplant model, we will then test the hypothesis that selective inhibition of calcineurin isoforms results in immune suppression with fewer side-effects. [unreadable] [unreadable] [unreadable]..
  12. Transgenic Cytokines in COPD
    Tao Zheng; Fiscal Year: 2007
    ..3) Characterize the expression and roles of IL-13 and/or IFN-gamma in murine CS-induced emphysema. ..
  13. Genetic Linkage Analysis of Liver Disease in Mice
    JAMES GORHAM; Fiscal Year: 2006
    ..This will have important implications for understanding the genetic basis of autoimmune hepatitis, and of hepatocellular damage in the settings of HCV infection. ..
  14. The stress of dry eye on corneal barrier function
    CINTIA DE PAIVA; Fiscal Year: 2006
    ..TJ and LEP expression will be evaluated by laser scanning confocal microscopy and immunostaining. Pro inflammatory mediator expression will be evaluated by Western Blot, ELISA and the Luminex Multiplex Assay. [unreadable] [unreadable]..
  15. Expression profiling of human islets
    KLAUS KAESTNER; Fiscal Year: 2006
    ....
  16. Stromal TGFbeta in tumor progression
    Nikki Cheng; Fiscal Year: 2006
    ....
  17. MATERNAL IMMUNE TOLERANCE TO THE ALLOGENEIC FETUS
    Adrian Erlebacher; Fiscal Year: 2003
    ..Genes will be isolated by cDNA representational difference analysis and DNA microchip array analysis. and will be functionally evaluated by their ability to modulate tumor immunogenicity in vivo. ..
  18. Mechanisms of TGFbeta-mediated fibroblastic transition
    Andrei Bakin; Fiscal Year: 2006
    ..The proposed research will help to define the TGFbeta signaling network and will facilitate the design of novel selective inhibition of TGFbeta's tumor promoting activity. ..
  19. Mechanisms of liver disease in a mouse model of AIH
    JAMES GORHAM; Fiscal Year: 2006
    ..The final aim is to analyze the genetics, mechanisms, and specificity of hepatic BALB/c-TGF-b1(-/-) effector cytotoxic T lymphocytes. ..
  20. Characterization of Corneal Epithelial Stem Cells
    Mary Ann Stepp; Fiscal Year: 2005
    ..Discovering specific molecular markers for the limbal stem cells will aid in the development of treatments for stem cell deficiency diseases of the ocular surface in humans. ..
  21. Immunogenetics of Leishmania chagasi Infection
    Mary Wilson; Fiscal Year: 2005
    ..chagasi infection, and to identify specific alleles that influence human immune responses and thereby modify the course of disease. ..
  22. The Major Surface Protease of Trypanosomatid Protozoa
    Mary Wilson; Fiscal Year: 2003
    ..chagasi whose coding sequences predict they lack the usual GPI anchor, and to contrast the amino acid sequences that regulate the intracellular trafficking of these unusual MSPs with the MSPs that possess a GPI membrane anchor. ..
  23. CELLULAR PATHWAYS OF OCULAR IMMUNOREGULATION
    ROBERT CONE; Fiscal Year: 2003
    ..Understanding of this axis could impact on the management o f inflammatory eye disease, organ transplants (e.g. cornea), ocular tumors and autoimmune disease. ..
  24. FUNCTION OF A GROWTH INDUCED GENE IN LIVER REGENERATION
    KLAUS KAESTNER; Fiscal Year: 2003
    ....
  25. SHIP-2 influence on macrophage Fc receptor function
    Susheela Tridandapani; Fiscal Year: 2009
    ..The proposed work holds promise for a better understanding of the IC-mediated inflammatory diseases at the molecular level, and paves the way for novel therapeutic targets. ..
  26. Signaling Mechanisms Regulating Cardiac Remodeling
    STEVEN KUBALAK; Fiscal Year: 2009
    ..2) To determine how retinoic acid signaling regulates TGFbeta2-induced apoptosis and remodeling in the outflow tract. 3) To determine if RXRalpha directly interacts with Smad signaling in the outflow tract. ..
  27. Signaling Pathways in Pathogenesis of Renal Fibrosis
    JOSEPH GRANDE; Fiscal Year: 2004
    ..If successful, these interventions may retard progression of tissue injury to end-stage disease. ..
  28. ROLE OF NF-KB IN TGF-B1 INDUCED APOPTOSIS OF HEPATOCYTES
    Marcello Arsura; Fiscal Year: 2005
    ..Furthermore, these findings will provide important insights into the role of NF- kappaB/Rel factors in the control of apoptosis of normal and transformed hepatocytes of potential clinical relevance. ..
  29. Ocular Regulation of Autoimmunity
    ROBERT CONE; Fiscal Year: 2009
    ..The results of this study could aid our understanding of the systemic basis for the ocular regulation of autoimmunity and develop procedures for the modulation of active autoimmune disease. ..
  30. CARDIOVASCULAR REMODELING MEDIATED BY RXRa RECEPTORS
    STEVEN KUBALAK; Fiscal Year: 2003
    ..III) To test the hypothesis that disruption of RXRalpha expression during cardiogenesis results in cardiac defects that are TGFbeta2 dependent. ..
  31. CELLULAR SIGNALING IN RENAL PATHOPHYSIOLOGY
    JOSEPH GRANDE; Fiscal Year: 2008
    ..abstract_text> ..
  32. Development of C57BL/6 ES cell technology for high thoughput use.
    KLAUS KAESTNER; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  33. TGF-beta Signaling in Mesenchymal Chondroprogenitors
    Anna Spagnoli; Fiscal Year: 2007
    ..Understanding the role of TGF-beta in MCC biology will provide a framework for therapeutic manipulations to optimize the use of MCC in cartilage diseases. ..
  34. GP63 EXPRESSION IN LEISHMANIA CHAGASI
    Mary Wilson; Fiscal Year: 2001
    ..They will also provide a model for differential expression of tandemly linked genes in this group of protozoa. ..
  35. A novel inbred mouse model of autoimmune hepatitis
    JAMES GORHAM; Fiscal Year: 2002
    ..The proposal seeks to understand mechanisms that regulate the development of inflammation in the liver, so as to gain insights into the pathogenic mechanisms of AIH and other hepatic inflammatory diseases. ..