tenascin C

Summary

Gene Symbol: tenascin C
Description: tenascin C
Alias: AI528729, C130033P17Rik, Hxb, TN-C, Ten, cytotactin, tenascin-C, tenascin, hexabrachion, tnc
Species: mouse

Top Publications

  1. ncbi Migration of dopaminergic neurons in the embryonic mesencephalon of mice
    H Kawano
    Department of Anatomy, School of Medicine, Keio University, Tokyo, Japan
    Brain Res Dev Brain Res 86:101-13. 1995
  2. ncbi Analysis of tenascin mRNA expression in the murine mammary gland from embryogenesis to carcinogenesis: an in situ hybridization study
    I Kalembey
    Second Department of Surgery, Mie University School of Medicine, Tsu, Japan
    Int J Dev Biol 41:569-73. 1997
  3. ncbi Pax6 controls radial glia differentiation in the cerebral cortex
    M Gotz
    Department of Molecular Cell Biology, Max Planck Institute of Biophysical Chemistry, Gottingen, Federal Republic of Germany
    Neuron 21:1031-44. 1998
  4. ncbi Knockout mice reveal a contribution of the extracellular matrix molecule tenascin-C to neural precursor proliferation and migration
    E Garcion
    Department of Medical Genetics and Cambridge Center for Brain Repair, University of Cambridge, UK
    Development 128:2485-96. 2001
  5. ncbi Tenascin-C upregulates matrix metalloproteinase-9 in breast cancer cells: direct and synergistic effects with transforming growth factor beta1
    Ilunga Kalembeyi
    Department of Pathology, Mie University School of Medicine, Tsu, Mie, Japan
    Int J Cancer 105:53-60. 2003
  6. ncbi Alternatively spliced variants of protocadherin 8 exhibit distinct patterns of expression during mouse development
    Helen Makarenkova
    The Neurosciences Institute, 10640 John Jay Hopkins Drive, San Diego, CA 92121, USA
    Biochim Biophys Acta 1681:150-6. 2005
  7. ncbi Expression of the integrin subunit alpha 9 in the murine embryo
    A Wang
    Lung Biology Center, San Francisco General Hospital, University of California 94143, USA
    Dev Dyn 204:421-31. 1995
  8. ncbi Upregulation of alpha 9 integrin and tenascin during epithelial regeneration after debridement in the cornea
    M A Stepp
    Department of Anatomy, George Washington University Medical Center, Washington, DC 20037, USA
    J Histochem Cytochem 45:189-201. 1997
  9. ncbi Mice develop normally without tenascin
    Y Saga
    Laboratory of Cell Biology, Tsukuba Life Science Center, Institute of Physical and Chemical Research RIKEN, Ibaraki, Japan
    Genes Dev 6:1821-31. 1992
  10. pmc Tenascin during gut development: appearance in the mesenchyme, shift in molecular forms, and dependence on epithelial-mesenchymal interactions
    E Aufderheide
    Friederich Miescher Laboratorium der Max Planck Gesellschaft, Tubingen, Federal Republic of Germany
    J Cell Biol 107:2341-9. 1988

Research Grants

  1. RUNX2 AND PPAR-GAMMA IN CHONDROCYTE FUNCTION
    Masahiro Iwamoto; Fiscal Year: 2009
  2. Development of the primary olfactory pathway
    Helen Treloar; Fiscal Year: 2005
  3. Characterization of Corneal Epithelial Stem Cells
    Mary Ann Stepp; Fiscal Year: 2005
  4. Is non-canonical Wnt signaling required in cardiac neural crest cells?
    Ethan David Cohen; Fiscal Year: 2008
  5. Development of the primary olfactory pathway
    Helen Treloar; Fiscal Year: 2009

Scientific Experts

Detail Information

Publications131 found, 100 shown here

  1. ncbi Migration of dopaminergic neurons in the embryonic mesencephalon of mice
    H Kawano
    Department of Anatomy, School of Medicine, Keio University, Tokyo, Japan
    Brain Res Dev Brain Res 86:101-13. 1995
    ..The expression of tenascin was transiently seen on radial glial processes between E10 and E13 coincident with the period of the ventral ..
  2. ncbi Analysis of tenascin mRNA expression in the murine mammary gland from embryogenesis to carcinogenesis: an in situ hybridization study
    I Kalembey
    Second Department of Surgery, Mie University School of Medicine, Tsu, Japan
    Int J Dev Biol 41:569-73. 1997
    The expression of tenascin gene during murine mammary gland development was analyzed by in situ hybridization with non-radioactive cRNA probes. The aim was to identify whether cells that synthesize tenascin are mesenchymal or epithelial...
  3. ncbi Pax6 controls radial glia differentiation in the cerebral cortex
    M Gotz
    Department of Molecular Cell Biology, Max Planck Institute of Biophysical Chemistry, Gottingen, Federal Republic of Germany
    Neuron 21:1031-44. 1998
    ..In Pax6-deficient mice, cortical radial glia cells were altered in their morphology, number, tenascin-C (TN-C) expression, and cell cycle...
  4. ncbi Knockout mice reveal a contribution of the extracellular matrix molecule tenascin-C to neural precursor proliferation and migration
    E Garcion
    Department of Medical Genetics and Cambridge Center for Brain Repair, University of Cambridge, UK
    Development 128:2485-96. 2001
    The extracellular matrix glycoprotein tenascin-C is widely expressed in the vertebrate central nervous system (CNS) during development and repair...
  5. ncbi Tenascin-C upregulates matrix metalloproteinase-9 in breast cancer cells: direct and synergistic effects with transforming growth factor beta1
    Ilunga Kalembeyi
    Department of Pathology, Mie University School of Medicine, Tsu, Mie, Japan
    Int J Cancer 105:53-60. 2003
    b>Tenascin-C (TN-C) and matrix metalloproteinases (MMPs) are highly expressed in cancer tissues and probably promote cell migration during cancer progression...
  6. ncbi Alternatively spliced variants of protocadherin 8 exhibit distinct patterns of expression during mouse development
    Helen Makarenkova
    The Neurosciences Institute, 10640 John Jay Hopkins Drive, San Diego, CA 92121, USA
    Biochim Biophys Acta 1681:150-6. 2005
    ..The differential expression of two alternative cytoplasmic domain variants suggests that Pcdh8 may regulate cell adhesion in a variety of developmental processes, and that this may involve different intracellular interactions...
  7. ncbi Expression of the integrin subunit alpha 9 in the murine embryo
    A Wang
    Lung Biology Center, San Francisco General Hospital, University of California 94143, USA
    Dev Dyn 204:421-31. 1995
    ..far, only a single alpha 9-containing integrin has been identified (alpha 9 beta 1) and only a single ligand (tenascin) has been found for this integrin...
  8. ncbi Upregulation of alpha 9 integrin and tenascin during epithelial regeneration after debridement in the cornea
    M A Stepp
    Department of Anatomy, George Washington University Medical Center, Washington, DC 20037, USA
    J Histochem Cytochem 45:189-201. 1997
    ..9 beta b1 is one of the newer members of the integrin beta family and has been recently shown to function as a tenascin receptor...
  9. ncbi Mice develop normally without tenascin
    Y Saga
    Laboratory of Cell Biology, Tsukuba Life Science Center, Institute of Physical and Chemical Research RIKEN, Ibaraki, Japan
    Genes Dev 6:1821-31. 1992
    b>Tenascin, an extracellular matrix protein, is expressed in an unusually restricted pattern during embryogenesis and has been implicated in a variety of morphogenetic phenomena...
  10. pmc Tenascin during gut development: appearance in the mesenchyme, shift in molecular forms, and dependence on epithelial-mesenchymal interactions
    E Aufderheide
    Friederich Miescher Laboratorium der Max Planck Gesellschaft, Tubingen, Federal Republic of Germany
    J Cell Biol 107:2341-9. 1988
    b>Tenascin, an extracellular matrix protein, is expressed in the mesenchyme around growing epithelia in the embryo. We therefore investigated whether epithelial cells can stimulate expression of tenascin in embryonic mesenchyme...
  11. ncbi Tenascin-C expression in dystrophin-related muscular dystrophy
    D L Settles
    Department of Cell Biology, Duke University, Durham, North Carolina 27710, USA
    Muscle Nerve 19:147-54. 1996
    ..We investigated whether regenerating mdx skeletal muscle contains the extracellular matrix protein tenascin-C (TN-C), which is expressed in wound healing and nerve regeneration...
  12. ncbi Tenascin-C and the development of articular cartilage
    M Pacifici
    Department of Anatomy and Histology, School of Dental Medicine, University of Pennsylvania, Philadelphia, USA
    Matrix Biol 14:689-98. 1995
    ..this minireview, we summarize recent studies from our laboratory suggesting that the extracellular matrix protein tenascin-C is involved in the genesis and function of articular chondrocytes...
  13. ncbi Bergmann glial development in the mouse cerebellum as revealed by tenascin expression
    S Yuasa
    Laboratory of Neural Information, National Institute for Physiological Sciences, Okazaki, Japan
    Anat Embryol (Berl) 194:223-34. 1996
    b>Tenascin, an astroglia-derived extracellular matrix molecule, is also expressed by radial glia of the embryonic mouse cerebellum...
  14. ncbi The peripheral nerve and the neuromuscular junction are affected in the tenascin-C-deficient mouse
    C Cifuentes-Diaz
    Laboratoire Neuromodulations Interactives et Neuropathologies, INSERM, Paris, France
    Cell Mol Biol (Noisy-le-grand) 44:357-79. 1998
    A thorough examination of the structure and plasticity of the neuromuscular system was performed in tenascin-C mutant mice deficient in tenascin-C. The study of the peripheral nerve revealed a number of abnormal features...
  15. ncbi Effect of tenascin-C deficiency on chemically induced dermatitis in the mouse
    Y Koyama
    Division of Experimental Animal Research, Tsukuba Life Science Center, The Institute of Physical and Chemical Research RIKEN, Ibaraki, Japan
    J Invest Dermatol 111:930-5. 1998
    b>Tenascin-C is a large extracellular matrix glycoprotein characterized by its spatiotemporal expression during embryogenesis, carcinogenesis, and wound healing...
  16. ncbi Parathyroid hormone-related protein signaling is necessary for sexual dimorphism during embryonic mammary development
    M E Dunbar
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520 8020, USA
    Development 126:3485-93. 1999
    ..In addition, the expression of tenascin C, another marker of the mammary mesenchyme, is also dependent on PTHrP...
  17. ncbi Fetal lungs of tenascin-C-deficient mice grow well, but branch poorly in organ culture
    Matthias Roth-Kleiner
    Institute of Anatomy, University of Bern, Buehlstrasse 26, CH 3000 Bern 9, Switzerland
    Am J Respir Cell Mol Biol 30:360-6. 2004
    b>Tenascin-C (TNC) is a multidomain extracellular matrix protein that contributes to organogenesis and tumorgenesis...
  18. ncbi Murine tenascin-W: a novel mammalian tenascin expressed in kidney and at sites of bone and smooth muscle development
    A Scherberich
    Friedrich Miescher Institute for Biomedical Research, Novartis Research Foundation, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
    J Cell Sci 117:571-81. 2004
    We cloned and characterized a novel member of the tenascin family of extracellular matrix proteins--the murine orthologue of zebrafish tenascin-W. Full-length recombinant tenascin-W was expressed and purified from mammalian cell cultures...
  19. ncbi Deficiency of tenascin C attenuates allergen-induced bronchial asthma in the mouse
    Hiroki Nakahara
    Department of Pulmonary and Critical Care Medicine, Mie University Graduate School of Medicine, Tsu City, Japan
    Eur J Immunol 36:3334-45. 2006
    b>Tenascin C (TN-C) is an extracellular matrix glycoprotein whose expression is increased in several inflammatory diseases of the lung, including bronchial asthma...
  20. ncbi The adult mouse subependymal zone regenerates efficiently in the absence of tenascin-C
    Ilias Kazanis
    Department of Pathology, University of Cambridge, Cambridge CB2 1QP, United Kingdom
    J Neurosci 27:13991-6. 2007
    ..b>Tenascin-C is a large extracellular matrix glycoprotein present in the SEZ that has been shown to regulate the development ..
  21. doi Tenascin-C is an endogenous activator of Toll-like receptor 4 that is essential for maintaining inflammation in arthritic joint disease
    Kim Midwood
    Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College of Science, Technology and Medicine, London, UK
    Nat Med 15:774-80. 2009
    ..b>Tenascin-C (encoded by Tnc) is an extracellular matrix glycoprotein specifically expressed at areas of inflammation and ..
  22. doi Tenascin-C triggers fibrin accumulation by downregulation of tissue plasminogen activator
    Florence Brellier
    Friedrich Miescher Institute for Biomedical Research, Novartis Research Foundation, Basel, Switzerland
    FEBS Lett 585:913-20. 2011
    We explored novel functions of tenascin-C by comparing mouse embryonic fibroblasts (MEFs) proficient or deficient in tenascin-C expression...
  23. doi The transcriptional regulator megakaryoblastic leukemia-1 mediates serum response factor-independent activation of tenascin-C transcription by mechanical stress
    Maria B Asparuhova
    Friedrich Miescher Institute for Biomedical Research, Novartis Research Foundation, Maulbeerstrasse 66, 4058 Basel, Switzerland
    FASEB J 25:3477-88. 2011
    The extracellular matrix protein tenascin-C (TNC) is up-regulated in processes influenced by mechanical stress, such as inflammation, tissue remodeling, wound healing, and tumorigenesis...
  24. doi Tenascin-C is expressed in abdominal aortic aneurysm tissue with an active degradation process
    Taizo Kimura
    Department of Molecular Cardiovascular Biology, Yamaguchi University School of Medicine, Kurume, Japan
    Pathol Int 61:559-64. 2011
    ..Currently no biomarkers have been established to indicate the disease status of AAA. Tenascin-C (TN-C) is a matricellular protein that is synthesized under pathological conditions...
  25. pmc Parathyroid hormone-related protein activates Wnt signaling to specify the embryonic mammary mesenchyme
    Minoti Hiremath
    Department of Biological Sciences, Boise State University, Boise, ID 83725, USA
    Development 139:4239-49. 2012
    ..Therefore, we conclude that a mesenchymal, canonical Wnt pathway mediates the PTHrP-dependent specification of the mammary mesenchyme...
  26. ncbi Murine tenascin: cDNA cloning, structure and temporal expression of isoforms
    Y Saga
    Laboratory of Cell Biology, Tsukuba Life Science Center, Ibaraki, Japan
    Gene 104:177-85. 1991
    Mouse tenascin (TN)-encoding cDNA clones were isolated from a cDNA library of the 2H6GR mammary tumor cell line...
  27. pmc Skin wounds and severed nerves heal normally in mice lacking tenascin-C
    E Forsberg
    Max Planck Institute for Biochemistry, Martinsried, Germany
    Proc Natl Acad Sci U S A 93:6594-9. 1996
    A large number of functions have been demonstrated for tenascin-C by antibody perturbation assays and in vitro cell culture experiments...
  28. pmc Multiple promoter elements differentially regulate the expression of the mouse tenascin gene
    D W Copertino
    Department of Neurobiology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 94:1846-51. 1997
    b>Tenascin (TN) is an extracellular matrix glycoprotein that is expressed in a characteristic spatiotemporal pattern during development and is up-regulated in the adult during tumorigenesis, wound healing, and nerve regeneration...
  29. ncbi The tenascin-C knockout revisited
    E J Mackie
    School of Veterinary Science, University of Melbourne, Parkville, Victoria, Australia
    J Cell Sci 112:3847-53. 1999
    In the past seven years, two groups have independently produced tenascin-C-knockout mice. These mice are born alive and, originally, were described as showing no abnormalities...
  30. ncbi The dynamic expression of tenascin-C and tenascin-X during early heart development in the mouse
    Kyoko Imanaka-Yoshida
    Department of Pathology, Mie University School of Medicine, 2 174 Edobashi, Tsu, Mie 514 8507 Japan
    Differentiation 71:291-8. 2003
    One of a family of extracellular matrix proteins, tenascin-C (TNC) is expressed in a spatiotemporally restricted pattern associated with tissue remodeling during embryonic development, wound healing, cancer invasion and tissue ..
  31. ncbi Deficiency of tenascin-C attenuates liver fibrosis in immune-mediated chronic hepatitis in mice
    A El-Karef
    Department of Pathology and Matrix Biology, Graduate School of Medicine, Mie University, Mie, Japan
    J Pathol 211:86-94. 2007
    b>Tenascin-C (TNC), an extracellular matrix glycoprotein, is upregulated in chronic liver disease...
  32. pmc Bone ridge patterning during musculoskeletal assembly is mediated through SCX regulation of Bmp4 at the tendon-skeleton junction
    Einat Blitz
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel
    Dev Cell 17:861-73. 2009
    ..This study establishes a mechanistic basis for tendon-skeleton regulatory interactions during musculoskeletal assembly and bone secondary patterning...
  33. pmc Tenascin-C deficiency attenuates TGF-ß-mediated fibrosis following murine lung injury
    William A Carey
    Cardiovascular Research Institute, University of California, San Francisco, USA
    Am J Physiol Lung Cell Mol Physiol 299:L785-93. 2010
    b>Tenascin-C (TNC) is an extracellular matrix glycoprotein of unknown function that is highly expressed in adult lung parenchyma following acute lung injury (ALI)...
  34. pmc Spatial and temporal expression of molecular markers and cell signals during normal development of the mouse patellar tendon
    Chia Feng Liu
    Division of Developmental Biology, Cincinnati Children s Hospital Research Foundation, Cincinnati, OH 45229, USA
    Tissue Eng Part A 18:598-608. 2012
    ..We found that collagen I, fibromodulin, and tenomodulin were expressed throughout the tendon, whereas tenascin-C, biglycan, and cartilage oligomeric protein were concentrated in the insertion site during this period...
  35. ncbi Corneal wound healing in tenascin knockout mouse
    A Matsuda
    Department of Ophthalmology, Hokkaido University School of Medicine, Sapporo, Japan
    Invest Ophthalmol Vis Sci 40:1071-80. 1999
    b>Tenascin (TN) is a large hexameric extracellular matrix glycoprotein that is expressed in developing organs and tumors. It has also been reported that TN is expressed in the embryonic cornea and during corneal wound healing...
  36. ncbi Neural stem/progenitor cells express 20 tenascin C isoforms that are differentially regulated by Pax6
    Alexander von Holst
    Department of Cell Morphology and Molecular Neurobiology, Ruhr University Bochum, D 44780 Bochum, Germany
    J Biol Chem 282:9172-81. 2007
    b>Tenascin C (Tnc) is an alternatively spliced, multimodular extracellular matrix glycoprotein present in the ventricular zone of the developing brain. Pax6-deficient small eye (sey) mouse mutants show an altered Tnc expression pattern...
  37. doi Tenascin-C induction by cyclic strain requires integrin-linked kinase
    Silke Maier
    Friedrich Miescher Institute for Biomedical Research, Novartis Research Foundation, CH 4058 Basel, Switzerland
    Biochim Biophys Acta 1783:1150-62. 2008
    Induction of tenascin-C mRNA by cyclic strain in fibroblasts depends on RhoA and Rho dependent kinase (ROCK). Here we show that integrin-linked kinase (ILK) is required upstream of this pathway...
  38. doi Specific glial populations regulate hippocampal morphogenesis
    Guy Barry
    The University of Queensland, Queensland Brain Institute, and School of Biomedical Sciences, Brisbane, 4067, Australia
    J Neurosci 28:12328-40. 2008
    ..These data demonstrate a role for Nfib in hippocampal fissure and dentate gyrus formation, and that distinct glial bundles are critical for correct hippocampal morphogenesis...
  39. ncbi Tenascin mRNA isoforms in the developing mouse brain
    U Dörries
    Department of Neurobiology, Swiss Federal Institute of Technology, Zurich
    J Neurosci Res 37:336-47. 1994
    The extracellular matrix glycoprotein tenascin is expressed in the developing mouse cerebellum as a group of four protein species of different molecular weights...
  40. ncbi The tenascin gene family
    R Chiquet-Ehrismann
    Friedrich Miescher Institute, Basel, Switzerland
    Perspect Dev Neurobiol 2:3-7. 1994
    ..the family of tenascin-like genes and we review in this article the structures of the original tenascin/cytotactin (tenascin-C), restrictin/J-160/180 (tenascin-R), and the tenascin-like gene present in the major ..
  41. ncbi Tyrosine hydroxylase activity and its mRNA level in dopaminergic neurons of tenascin gene knockout mouse
    F Fukamauchi
    Department of Molecular Medical Science, Tokyo Medical and Dental University, Japan
    Biochem Biophys Res Commun 231:356-9. 1997
    We have recently demonstrated that some tenascin (TN) gene-knockout mice display abnormal behaviors, and that these abnormal behaviors stem from a low level of dopamine transmission in the brain...
  42. ncbi Suppression of hematopoietic activity in tenascin-C-deficient mice
    M Ohta
    Division of Biochemistry, Cancer Institute, Hokkaido University, School of Medicine, Sapporo, Japan
    Blood 91:4074-83. 1998
    b>Tenascin-C (TN-C), a member of the extracellular matrix (ECM) glycoprotein family, is expressed on the surface of stromal cells in the hematopoietic system or lymphoid organs...
  43. ncbi Myelination and behaviour of tenascin-C null transgenic mice
    B W Kiernan
    Wellcome CRC Institute of Developmental Biology and Cancer, Cambridge, UK
    Eur J Neurosci 11:3082-92. 1999
    The extracellular matrix glycoprotein tenascin-C is widely expressed during development and repair, making it surprising that few abnormalities have been found in transgenic mice lacking this molecule...
  44. ncbi Loss of cortical and thalamic neuronal tenascin-C expression in a transgenic mouse expressing exon 1 of the human Huntington disease gene
    M Kusakabe
    Division of Experimental Animal Research, RIKEN, Tsukuba, Japan
    J Comp Neurol 430:485-500. 2001
    ..The present study has found that expression of the extracellular matrix glycoprotein tenascin-C appears to be unaffected in astroglial cells in wild-type and R6/2 transgenic mice that express the mutant ..
  45. ncbi Neural bHLH genes control the neuronal versus glial fate decision in cortical progenitors
    M Nieto
    Institut de Génétique et de Biologie Moléculaire, et Cellulaire, CNRS, INSERM, Universite, Louis Pasteur, Boite Postale 163, 67404 Illkirch Cedex, Communauté urbaine de, Strasbourg, France
    Neuron 29:401-13. 2001
    ..Together, these results demonstrate that proneural genes are involved in lineage restriction of cortical progenitors, promoting the acquisition of the neuronal fate and inhibiting the astrocytic fate...
  46. ncbi Localization of extracellular matrix receptors in ICGN mice, a strain of mice with hereditary nephrotic syndrome
    K Uchio-Yamada
    Unit of Anatomy and Cell Biology, Department of Animal Sciences, Kyoto University, Japan
    J Vet Med Sci 63:1171-8. 2001
    ..Marked deposition of type I collagen and tenascin was seen only in the glomeruli of ICGN mice but not in those of ICR mice as normal controls...
  47. ncbi Expression of NG2 proteoglycan during endochondral and intramembranous ossification
    Jun ichi Fukushi
    The Burnham Institute, La Jolla, California 92037, USA
    Dev Dyn 228:143-8. 2003
    ..chondrocytes, NG2 was up-regulated during primary ossification, colocalizing with alkaline phosphatase and tenascin C. In the epiphyseal growth plates of newborn mouse tibia, NG2 and alkaline phosphatase exhibited overlapping ..
  48. ncbi Development of heart valve leaflets and supporting apparatus in chicken and mouse embryos
    Joy Lincoln
    Division of Molecular Cardiovascular Biology, Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    Dev Dyn 230:239-50. 2004
    ..characteristics of chondrogenesis and tendon development, identified by scleraxis, type II collagen, and tenascin expression...
  49. pmc An Nkx2-5/Bmp2/Smad1 negative feedback loop controls heart progenitor specification and proliferation
    Owen W J Prall
    Victor Chang Cardiac Research Institute, Sydney 2010, Australia
    Cell 128:947-59. 2007
    ....
  50. pmc Recruitment and maintenance of tendon progenitors by TGFbeta signaling are essential for tendon formation
    Brian A Pryce
    Shriners Hospital for Children, Research Division, Portland, OR 97239, USA
    Development 136:1351-61. 2009
    ....
  51. pmc Tenascin-C is an inhibitory boundary molecule in the developing olfactory bulb
    Helen B Treloar
    Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut 06520 8082, USA
    J Neurosci 29:9405-16. 2009
    We recently described the boundary-like expression pattern of the extracellular matrix molecule tenascin-C (Tnc) in the developing mouse olfactory bulb (OB) (Shay et al., 2008)...
  52. pmc Wnt signaling regulates smooth muscle precursor development in the mouse lung via a tenascin C/PDGFR pathway
    Ethan David Cohen
    Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Clin Invest 119:2538-49. 2009
    ..the effect on Pdgfr expression was, in part, mediated by direct transcriptional regulation of the ECM protein tenascin C (Tnc), which was necessary and sufficient for Pdgfralpha/beta expression in lung explants...
  53. pmc Talin 1 and 2 are required for myoblast fusion, sarcomere assembly and the maintenance of myotendinous junctions
    Francesco J Conti
    The Scripps Research Institute, Department of Cell Biology and Institute of Childhood and Neglected Diseases, La Jolla, CA 92037, USA
    Development 136:3597-606. 2009
    ..We conclude that talin 1 and 2 are crucial for skeletal muscle development, where they regulate myoblast fusion, sarcomere assembly and the maintenance of MTJs...
  54. doi Tenascin-C may aggravate left ventricular remodeling and function after myocardial infarction in mice
    Tomohiro Nishioka
    Dept of Pathology and Matrix Biology, Mie Univ Graduate School of Medicine, Tsu, Japan
    Am J Physiol Heart Circ Physiol 298:H1072-8. 2010
    b>Tenascin-C (TN-C) is an extracellular matrix glycoprotein with high bioactivity. It is expressed at low levels in normal adult heart, but upregulated under pathological conditions, such as myocardial infarction (MI). Recently, we (Ref...
  55. doi Novel function of tenascin-C, a matrix protein relevant to atherosclerosis, in platelet recruitment and activation under flow
    Mathieu Schaff
    Inserm Unité Mixte de Recherche S949, Etablissement Français du Sang Alsace 10, Strasbourg Cedex, France
    Arterioscler Thromb Vasc Biol 31:117-24. 2011
    ..In this context, we explored platelet adhesion and activation to tenascin-C (TN-C), a matrix protein preferentially found within atheroma.
  56. doi Impaired angiogenic response in the cornea of mice lacking tenascin C
    Takayoshi Sumioka
    Department of Ophthalmology, Wakayama Medical University, 811 1 Kimiidera, Wakayama, 641 0012, Japan
    Invest Ophthalmol Vis Sci 52:2462-7. 2011
    This study investigated the effects of loss of tenascin C (TNC) in the development of neovascularization in a corneal stroma in mice...
  57. pmc Extracellular matrix protein tenascin-C is required in the bone marrow microenvironment primed for hematopoietic regeneration
    Ayako Nakamura-Ishizu
    Department of Cell Differentiation, The Sakaguchi Laboratory, School of Medicine, Keio University, Tokyo, Japan
    Blood 119:5429-37. 2012
    ..Of the many ECM proteins, the expression of tenascin-C (TN-C) was found to be dramatically up-regulated during hematopoietic recovery after myeloablation...
  58. doi Tenascin C regulates proliferation and differentiation processes during embryonic retinogenesis and modulates the de-differentiation capacity of Müller glia by influencing growth factor responsiveness and the extracellular matrix compartment
    Manuela Besser
    Department of Cell Morphology and Molecular Neurobiology, Faculty of Biology and Biotechnology, Ruhr University Bochum, Germany
    Dev Biol 369:163-76. 2012
    ..This study focused on the functional analysis of the extracellular matrix (ECM) molecule Tenascin C (Tnc) in the retinal stem/progenitor cell environment...
  59. pmc Increased tenascin C and Toll-like receptor 4 levels in visceral adipose tissue as a link between inflammation and extracellular matrix remodeling in obesity
    Victoria Catalan
    Metabolic Research Laboratory, Department of Surgery, Clinica Universidad de Navarra, Avenuda Pío XII, 36, 31008 Pamplona, Spain
    J Clin Endocrinol Metab 97:E1880-9. 2012
    Obesity is associated with an altered inflammatory and extracellular matrix (ECM) profile. Tenascin C (TNC) is an ECM glycoprotein with proinflammatory effects.
  60. pmc Mesenchymal condensation-dependent accumulation of collagen VI stabilizes organ-specific cell fates during embryonic tooth formation
    Tadanori Mammoto
    Vascular Biology Program, Boston Children s Hospital and Harvard Medical School, Boston, Massachusetts
    Dev Dyn 244:713-23. 2015
    ..However, the mechanism by which cell compaction is stabilized over time to ensure correct organ-specific cell fate switching remains unknown...
  61. doi Deficiency of tenascin-C and attenuation of blood-brain barrier disruption following experimental subarachnoid hemorrhage in mice
    Masashi Fujimoto
    Departments of 1 Neurosurgery and
    J Neurosurg 124:1693-702. 2016
    OBJECT Tenascin-C (TNC), a matricellular protein, is induced in the brain following subarachnoid hemorrhage (SAH). The authors investigated if TNC causes brain edema and blood-brain barrier (BBB) disruption following experimental SAH...
  62. pmc Deletion of tenascin-C gene exacerbates atherosclerosis and induces intraplaque hemorrhage in Apo-E-deficient mice
    Lai Wang
    Oppenheimer Atherosclerosis Research Center and the Division of Cardiology, Cedars Sinai Heart Institute, Los Angeles, CA 90048, USA
    Cardiovasc Pathol 21:398-413. 2012
    b>Tenascin-C (TNC), a matricellular protein, is up-regulated in atherosclerotic plaques. We investigated whether the deletion of TNC gene affects the development of atherosclerosis in a murine model.
  63. doi Molecular profiling of synovial joints: use of microarray analysis to identify factors that direct the development of the knee and elbow
    Dorothy E Pazin
    Department of Developmental Biology, Harvard School of Dental Medicine, 188 Longwood Avenue, Boston, MA 02115, USA
    Dev Dyn 241:1816-26. 2012
    ..Here, we use microarray analysis to compare knee and elbow formation to identify factors involved in the development of specific joints...
  64. pmc Putative functions of extracellular matrix glycoproteins in secondary palate morphogenesis
    Rocca d'Amaro
    Department of Orthodontics and Dentofacial Orthopedics, School of Dental Medicine, University of Bern Bern, Switzerland
    Front Physiol 3:377. 2012
    ..In addition, we observed that tenascin-W (but not tenascin-C) was misexpressed in palatal shelves of Bmp7-deficient mouse embryos...
  65. doi Adult interfollicular tumour-initiating cells are reprogrammed into an embryonic hair follicle progenitor-like fate during basal cell carcinoma initiation
    Khalil Kass Youssef
    IRIBHM, Universite Libre de Bruxelles ULB, 808 Route de Lennik, 1070 Brussels, Belgium
    Nat Cell Biol 14:1282-94. 2012
    ..Deletion of β-catenin in adult SmoM2-expressing cells prevents EHFP reprogramming and tumour initiation. Finally, human basal cell carcinomas also express genes of the Wnt signalling and EHFP signatures...
  66. doi Primary hippocampal neurons, which lack four crucial extracellular matrix molecules, display abnormalities of synaptic structure and function and severe deficits in perineuronal net formation
    Maren Geissler
    Department of Cell Morphology and Molecular Neurobiology, Ruhr University, D 44780 Bochum, Germany
    J Neurosci 33:7742-55. 2013
    ..studied a mouse mutant that lacks four ECM components highly enriched in the developing brain: the glycoproteins tenascin-C and tenascin-R and the chondroitin sulfate proteoglycans brevican and neurocan...
  67. pmc Perichondrium phenotype and border function are regulated by Ext1 and heparan sulfate in developing long bones: a mechanism likely deranged in Hereditary Multiple Exostoses
    Julianne Huegel
    Division of Orthopaedic Surgery, The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Dev Biol 377:100-12. 2013
    ..Alterations in these mechanisms may contribute to exostosis formation in HME, particularly at the expense of regions rich in progenitor cells including the groove of Ranvier...
  68. ncbi In situ localization of tenascin mRNA in developing mouse teeth
    R P Tucker
    Department of Neurobiology and Anatomy, Bowman Gray School of Medicine, Wake Forest University, Winston Salem, NC 27157
    Arch Oral Biol 38:1025-9. 1993
    b>Tenascin is a large extracellular-matrix glycoprotein found in developing connective tissue...
  69. pmc The distribution of tenascin-X is distinct and often reciprocal to that of tenascin-C
    K Matsumoto
    Friedrich Miescher Institute, Basel, Switzerland
    J Cell Biol 125:483-93. 1994
    We have isolated a cDNA encoding mouse tenascin-X (TN-X), a new member of the family of tenascin genes. The TN-X gene lies in the major histocompatibility complex (MHC) class III region, as it is the case for its human counterpart...
  70. ncbi Tenascin glycoproteins in developing neural tissues: only decoration?
    A Faissner
    Department of Neurobiology, University of Heidelberg, Germany
    Perspect Dev Neurobiol 2:53-66. 1994
    b>Tenascin glycoproteins constitute a growing family of extracellular matrix molecules that are transiently expressed by astrocytes during the development of the central nervous system (CNS)...
  71. ncbi Tenascin-C inhibits extracellular matrix-dependent gene expression in mammary epithelial cells. Localization of active regions using recombinant tenascin fragments
    P L Jones
    Life Sciences Division, Lawrence Berkeley Laboratory, Berkeley, CA 94720, USA
    J Cell Sci 108:519-27. 1995
    The physiological role of tenascin in vivo has remained obscure. Although tenascin is regulated in a stage and tissue-dependent manner, knock-out mice appear normal...
  72. ncbi Receptor tyrosine kinase specific for the skeletal muscle lineage: expression in embryonic muscle, at the neuromuscular junction, and after injury
    D M Valenzuela
    Regeneron Pharmaceuticals, Inc, Tarrytown, New York 10591, USA
    Neuron 15:573-84. 1995
    ..Identification of MuSK introduces a novel receptor-factor system that seems sure to play an important and selective role in many aspects of skeletal muscle development and function...
  73. ncbi Tenascin-C, tenascin-R and tenascin-X: a family of talented proteins in search of functions
    H P Erickson
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710
    Curr Opin Cell Biol 5:869-76. 1993
    Mice develop normally without tenascin", was a shock to biologists studying the extracellular matrix. Could tenascin be a useless protein? This seems most improbable, as it is conserved in every vertebrate species...
  74. ncbi Linkage analysis of the whirler deafness gene on mouse chromosome 4
    J Fleming
    MRC Institute of Hearing Research, Nottingham, United Kingdom
    Genomics 21:42-8. 1994
    ..has positioned the wi locus in the interval between the genes for delta-aminolevulinate dehydratase (Lv) and hexabrachion (Hxb). The human homologues of these genes, ALAD and HXB, both lie on human chromosome 9q32-q34...
  75. ncbi Differential regulation of fibulin, tenascin-C, and nidogen expression during wound healing of normal and glucocorticoid-treated mice
    R Fassler
    Max Planck Institut fur Biochemie, Martinsried, Federal Republic of Germany
    Exp Cell Res 222:111-6. 1996
    Expression and distribution of fibulins, nidogen, and tenascin-C were analyzed in healing skin wounds of normal and dexamethasone-treated mice...
  76. ncbi Characterization of monoclonal antibodies against tenascin-C: no apparent effect on kidney development in vitro
    J F Talts
    Department of Animal Physiology, Uppsala University, Sweden
    Int J Dev Biol 41:39-48. 1997
    b>Tenascin-C is an extracellular matrix glycoprotein found in embryonic mesenchyme. The precise biological function of tenascin-C is unknown, but different parts of the molecule have effects on cell adhesion and other cellular activities...
  77. pmc The c-Jun-induced transformation process involves complex regulation of tenascin-C expression
    A Mettouchi
    Institut de Recherche sur le Cancer, CNRS UPR9079, Villejuif, France
    Mol Cell Biol 17:3202-9. 1997
    ..We identified c-Jun-upregulated cDNA clones homologous to the tenascin-C gene by differential screening of a cDNA library from REF...
  78. pmc Accumulation of muscle ankyrin repeat protein transcript reveals local activation of primary myotube endcompartments during muscle morphogenesis
    A Baumeister
    Friedrich Miescher Institute, P O Box 2543, CH 4002 Basel, Switzerland
    J Cell Biol 139:1231-42. 1997
    ....
  79. ncbi A single cysteine, Cys-64, is essential for assembly of tenascin-C hexabrachions
    J A Luczak
    Department of Molecular Biology, Princeton University, New Jersey 08544 1014, USA
    J Biol Chem 273:2073-7. 1998
    ..It is secreted from cells as a hexamer of six identical chains called a hexabrachion. Disulfide bonding among tenascin subunits mediates intracellular assembly into hexamers...
  80. ncbi Organization and reorganization of neuromuscular junctions in mice lacking neural cell adhesion molecule, tenascin-C, or fibroblast growth factor-5
    L M Moscoso
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 18:1465-77. 1998
    ..membrane-associated adhesion molecule, neural cell adhesion molecule (N-CAM), an extracellular matrix component, tenascin-C, and a soluble growth factor, fibroblast growth factor-5 (FGF-5)...
  81. ncbi A potential role for the OTX2 homeoprotein in creating early 'highways' for axon extension in the rostral brain
    K T Nguyen Ba-Charvet
    Institut Alfred Fessard, CNRS UPR 2212, Avenue de la Terrasse, France
    Development 125:4273-82. 1998
    ..Among the molecules upregulated with increasing levels of OTX2 are NCAM, tenascin-C and DSD-1-PG, which also in situ colocalize with zones of OTX2 expression at boundaries...
  82. ncbi YAC complementation shows a requirement for Wt1 in the development of epicardium, adrenal gland and throughout nephrogenesis
    A W Moore
    MRC Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh EH4 2XU, UK
    Development 126:1845-57. 1999
    ..These data demonstrate a variety of new functions for WT1 and suggest a general requirement for this protein in the formation of organs derived from the intermediate mesoderm...
  83. pmc Skeletal malformations caused by overexpression of Cbfa1 or its dominant negative form in chondrocytes
    C Ueta
    Department of Molecular Medicine, Osaka University Medical School, Suita, Osaka 565 0871, Japan
    J Cell Biol 153:87-100. 2001
    ..These data show that temporally and spatially regulated expression of Cbfa1 in chondrocytes is required for skeletogenesis, including formation of joints, permanent cartilages, and endochondral bones...
  84. ncbi Tenascin-C in developing mouse teeth: expression of splice variants and stimulation by TGFbeta and FGF
    C Sahlberg
    Institute of Biotechnology, Viikki Biocenter, University of Helsinki, Finland
    Eur J Oral Sci 109:114-24. 2001
    b>Tenascin-C is a protein of the extracellular matrix which has been suggested to regulate organogenesis. We have analysed the expression of tenascin-C mRNA during mouse tooth development...
  85. ncbi Pod1 is required in stromal cells for glomerulogenesis
    Shiying Cui
    The Samuel Lunenfeld Research Institute, Mt Sinai Hospital, Toronto, Ontario, Canada
    Dev Dyn 226:512-22. 2003
    ..Most strikingly, the glomerulogenesis defect was rescued by the presence of wild-type stromal cells, suggesting a non-cell autonomous role for Pod1 in this cell population...
  86. pmc Coregulation of fibronectin signaling and matrix contraction by tenascin-C and syndecan-4
    Kim S Midwood
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544 1014, USA
    Mol Biol Cell 15:5670-7. 2004
    ..b>Tenascin-C is an extracellular matrix protein that regulates cell response to fibronectin within the provisional matrix...
  87. ncbi Extracellular matrix alterations in brains lacking four of its components
    Uwe Rauch
    Department of Experimental Pathology, University Hospital, Lunds University, Lund, Sweden
    Biochem Biophys Res Commun 328:608-17. 2005
    ..were reported from several mouse strains lacking components of this matrix such as neurocan, brevican, tenascin-R, and tenascin-C...
  88. ncbi Vascular tenascin-C regulates cardiac endothelial phenotype and neovascularization
    Victoria L T Ballard
    Department of Medicine, Weill Medical College of Cornell University, New York, New York 10021, USA
    FASEB J 20:717-9. 2006
    ..pathways, in vivo bone marrow/cardiac phage display biopanning was performed and led to the identification of tenascin-C as a candidate protein...
  89. pmc Osteopontin is a novel marker of pancreatic ductal tissues and of undifferentiated pancreatic precursors in mice
    Gamze Kilic
    Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Dev Dyn 235:1659-67. 2006
    ..Finally, the maintenance of Opn expression in pancreatic tissues of adults argues for a possible function of this protein in injury and pathologic responses...
  90. ncbi Relevance of tenascin-C and matrix metalloproteinases in vascular abnormalities in murine hypoplastic lungs
    Mala R Chinoy
    Lung Development Research Program, Department of Surgery, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Biol Neonate 90:185-96. 2006
    b>Tenascin-C (TN-C), an extracellular matrix glycoprotein, is crucial to cell-migration, proliferation, apoptosis and remodeling of tissues, with a potential role in pathobiology of pulmonary hypertension...
  91. pmc Transcription factor ERG and joint and articular cartilage formation during mouse limb and spine skeletogenesis
    Masahiro Iwamoto
    Department of Orthopaedic Surgery, Thomas Jefferson University College of Medicine, Philadelphia, PA 19107, USA
    Dev Biol 305:40-51. 2007
    ..composed of chondrocytes actively expressing collagen IX and aggrecan as well as articular markers such as tenascin-C...
  92. ncbi Differential expression of phosphacan/RPTPbeta isoforms in the developing mouse visual system
    Alice Klausmeyer
    Department of Cellmorphology and Molecular Neurobiology, Ruhr University Bochum, 44801 Bochum, Germany
    J Comp Neurol 504:659-79. 2007
    ..In situ hybridization experiments support the conclusion that at least one of the phosphacan/RPTPbeta isoforms in the retina is expressed by neurons...
  93. pmc SM22alpha-targeted deletion of bone morphogenetic protein receptor 1A in mice impairs cardiac and vascular development, and influences organogenesis
    Nesrine El-Bizri
    Cardiopulmonary Research Program, Vera Moulton Wall Center for Pulmonary Vascular Disease, Stanford University School of Medicine, Stanford, California, CA, USA
    Development 135:2981-91. 2008
    ..Thus, loss of Bmpr1a, by decreasing MMP2 and/or MMP9 activity, can account for vascular dilatation and persistence of brain microvessels, leading to the impaired organogenesis documented in the brain...
  94. pmc Scleraxis is required for cell lineage differentiation and extracellular matrix remodeling during murine heart valve formation in vivo
    Agata K Levay
    Department of Molecular and Cellular Pharmacology, Leonard M Miller School of Medicine, University of Miami, Miami, FL 33101, USA
    Circ Res 103:948-56. 2008
    ..Collectively, our studies have identified an in vivo requirement for scx during valvulogenesis and demonstrate its role in cell lineage differentiation and matrix distribution in remodeling valve structures...
  95. doi Role of stromal tenascin-C in mouse prostatic development and epithelial cell differentiation
    Kenichiro Ishii
    Department of Nephro Urologic Surgery and Andrology, Mie University Graduate School of Medicine, 2 174 Edobashi, Tsu, Mie 514 8507, Japan
    Dev Biol 324:310-9. 2008
    ..Expression of tenascin-C (TN-C), an extracellular matrix (ECM) glycoprotein, is reportedly higher in BPH and PCa as compared with normal ..
  96. doi Implantation of dedifferentiated fat cells ameliorates habu snake venom-induced chronic renal dysfunction in tenascin-C-deficient mice
    Renaguli Nur
    Division of Nephrology, Hypertension and Endocrinology, Department of Medicine, Nihon University School of Medicine, Nihon University, Tokyo, Japan
    Nephron Exp Nephrol 110:e91-8. 2008
    ..In this study, we evaluated the effect of implantation of DFAT cells on habu snake venom (HSV)-induced renal dysfunction in tenascin-C knockout (TC-KO) mice.
  97. ncbi Role of fibrillar Tenascin-C in metastatic pancreatic cancer
    Jian Chen
    Hepatobiliary Surgery Institute, Southwest Hospital, Third Military Medical University, Chongqing, P R China
    Int J Oncol 34:1029-36. 2009
    ..In the tumor, upregulation of Tenascin-C (Tn-C) expression potentially can alter tumor behavior...
  98. doi Tenascin-C stimulates contactin-dependent neurite outgrowth via activation of phospholipase C
    Melanie Michele
    Department of Cell Morphology and Molecular Neurobiology, Ruhr University Bochum, Building ND 05 593, Universitatsstrabetae 150, D 44801 Bochum, Germany
    Mol Cell Neurosci 41:397-408. 2009
    b>Tenascin-C (Tnc) is transiently expressed during neural development...
  99. pmc Defective pulmonary vascular remodeling in Smad8 mutant mice
    Zheng Huang
    Institute of Biosciences and Technology, Texas A and M System Health Science Center, 2121 W Holcombe Blvd, Houston, TX 77030, USA
    Hum Mol Genet 18:2791-801. 2009
    ..pulmonary vasculature had upregulated Activin/Tgfbeta signaling and pathologic remodeling with aberrant Prx1 and Tenascin-C expression...

Research Grants5

  1. RUNX2 AND PPAR-GAMMA IN CHONDROCYTE FUNCTION
    Masahiro Iwamoto; Fiscal Year: 2009
    ..abstract_text> ..
  2. Development of the primary olfactory pathway
    Helen Treloar; Fiscal Year: 2005
    ..We have examined the expression patterns of four ECM molecules, tenascin, laminin, perlecan, and chondroitin sulfate proteoglycans (CSPGs)...
  3. Characterization of Corneal Epithelial Stem Cells
    Mary Ann Stepp; Fiscal Year: 2005
    ..Discovering specific molecular markers for the limbal stem cells will aid in the development of treatments for stem cell deficiency diseases of the ocular surface in humans. ..
  4. Is non-canonical Wnt signaling required in cardiac neural crest cells?
    Ethan David Cohen; Fiscal Year: 2008
    ..This.information may lead to new detection or treatment strategies. [unreadable] [unreadable] [unreadable]..
  5. Development of the primary olfactory pathway
    Helen Treloar; Fiscal Year: 2009
    ..We have identified members of the tenascin and chondroitin sulfate proteoglycans (CSPGs) as good candidates for the inhibitory cues that regulate axon ..