Tdgf1

Summary

Gene Symbol: Tdgf1
Description: teratocarcinoma-derived growth factor 1
Alias: CR1, cripto, teratocarcinoma-derived growth factor, TERATOCARCINOMA-DERIVED GROWTH FACTOR PRECURSOR (EPIDERMAL GROWTH FACTOR-LIKE CRIPTO PROTEIN) (CRIPTO GROWTH FACTOR), cripto growth factor, epidermal growth factor-like Cripto protein
Species: mouse

Top Publications

  1. ncbi Identification and biological characterization of an epidermal growth factor-related protein: cripto-1
    R Brandt
    Tumor Growth Factor Section, Laboratory of Tumor Immunology and Biology, NCI, National Institutes of Health, Bethesda, Maryland 20892
    J Biol Chem 269:17320-8. 1994
  2. ncbi Netrin-1 regulates invasion and migration of mouse mammary epithelial cells overexpressing Cripto-1 in vitro and in vivo
    Luigi Strizzi
    Mammary Biology and Tumorigenesis Laboratory, NCI CCR, 37 Convent Drive, Building 37, Bethesda, MD 20892, USA
    J Cell Sci 118:4633-43. 2005
  3. pmc Overexpression of human Cripto-1 in transgenic mice delays mammary gland development and differentiation and induces mammary tumorigenesis
    Youping Sun
    Tumor Growth Factor Section, Mammary Biology and Tumorigenesis Laboratory, National Cancer Institute, Bethesda, MD 20892, USA
    Am J Pathol 167:585-97. 2005
  4. ncbi Cripto in tumors and embryo development
    M G Persico
    International Institute of Genetics and Biophysics, CNR, Via G Marconi 12, 80125 Naples, Italy
    Biochim Biophys Acta 1552:87-93. 2001
  5. ncbi Cripto: a tumor growth factor and more
    Eileen D Adamson
    La Jolla Cancer Research Center, The Burnham Institute, La Jolla, California 92037, USA
    J Cell Physiol 190:267-78. 2002
  6. ncbi Role of the EGF-CFC gene cripto in cell differentiation and embryo development
    Gabriella Minchiotti
    International Institute of Genetics and Biophysics, CNR, Via Marconi 12, 80125 Naples, Italy
    Gene 287:33-7. 2002
  7. pmc Dual roles of Cripto as a ligand and coreceptor in the nodal signaling pathway
    Yu Ting Yan
    Center for Advanced Biotechnology and Medicine and Department of Pediatric, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    Mol Cell Biol 22:4439-49. 2002
  8. ncbi The Foxh1-dependent autoregulatory enhancer controls the level of Nodal signals in the mouse embryo
    Dominic P Norris
    Department of Molecular and Cellular Biology, Harvard University, The Biological Laboratories, Cambridge, MA 02138, USA
    Development 129:3455-68. 2002
  9. pmc Nodal-dependent Cripto signaling promotes cardiomyogenesis and redirects the neural fate of embryonic stem cells
    Silvia Parisi
    Institute of Genetics and Biophysics, Adriano Buzzati Traverso, Consiglio Naziolale delle Ricerche, Naples, Italy
    J Cell Biol 163:303-14. 2003
  10. ncbi Anterior neural plate regionalization in cripto null mutant mouse embryos in the absence of node and primitive streak
    Giovanna L Liguori
    Institute of Genetics and Biophysics A Buzzati Traverso, CNR, Via Guglielmo Marconi 12, 80125 Naples, Italy
    Dev Biol 264:537-49. 2003

Research Grants

  1. Mechanisms of activin antagonism
    Peter Gray; Fiscal Year: 2004
  2. The role of cell polarity in vertebrate limb outgrowth
    Jeffery Barrow; Fiscal Year: 2007

Scientific Experts

  • Kenichi Miharada
  • E N Olson
  • Eileen Adamson
  • M G Persico
  • PETER R GRAY
  • Jeffery R Barrow
  • A Chambery
  • Caterina Bianco
  • M M Shen
  • David R C Natale
  • G Minchiotti
  • Elizabeth J Robertson
  • Giovanna L Liguori
  • Daniel B Constam
  • Luigi Strizzi
  • David S Salomon
  • Daniela D'Andrea
  • Jixiang Ding
  • Daniel Mesnard
  • Marie Hélène Blanchet
  • Jianhua Chu
  • J Ann Le Good
  • Janet Rossant
  • Chiharu Kimura-Yoshida
  • Christian Wechselberger
  • Annamaria Liguoro
  • Youping Sun
  • Mario Mancino
  • Hiroshi Hamada
  • Olov Andersson
  • Shilpi Minocha
  • Katsuyoshi Takaoka
  • E Tian
  • Martyn Donnison
  • Nadia P Castro
  • Nicola Normanno
  • Robert Callahan
  • Emilia Giorgio
  • Ahmed Raafat
  • Jiu Zhen Jin
  • Sonja Nowotschin
  • Morihisa Hirota
  • Isao Matsuo
  • Shinichi Aizawa
  • Ombretta Guardiola
  • Canhe Chen
  • Tadahiro Nagaoka
  • G Liguori
  • Vittorio Sebastiano
  • Enza Lonardo
  • Masayuki Uehara
  • Gidi Shani
  • Sebastian J Arnold
  • Judith Klumperman
  • Nikolas Uez
  • Axel Schweickert
  • Monica Gonzales
  • Anjali Shukla
  • Kazuhide Watanabe
  • Yu Ting Yan
  • Akihiko Ishimura
  • Peter L Pfeffer
  • Viola Oorschot
  • Stéphane Baflast
  • Masamichi Yamamoto
  • Yu Liu
  • Aida Di-Gregorio
  • C Xu
  • Luisa Izzi
  • Shinya Oki
  • Alla A Bondareva
  • Yukio Saijoh
  • Shin Hamada
  • Salvador Martinez
  • Nadav Ben-Haim
  • Hiroshi Nakano
  • Andrew S Rakeman
  • Claire Chazaud
  • Pantelis Georgiades
  • Diego Echevarria
  • Xin Wang
  • N Gotoh
  • Yuji Mishina
  • Jeffrey L Wrana
  • Maki Wakamiya
  • Elizabeth K Bikoff
  • Kai Christian Sonntag
  • Kathryn V Anderson
  • Nicholas Kenney
  • Qinghua Tao

Detail Information

Publications95

  1. ncbi Identification and biological characterization of an epidermal growth factor-related protein: cripto-1
    R Brandt
    Tumor Growth Factor Section, Laboratory of Tumor Immunology and Biology, NCI, National Institutes of Health, Bethesda, Maryland 20892
    J Biol Chem 269:17320-8. 1994
    The human and mouse cripto-1 (CR-1) genes can code for proteins related in structure to epidermal growth factor (EGF)...
  2. ncbi Netrin-1 regulates invasion and migration of mouse mammary epithelial cells overexpressing Cripto-1 in vitro and in vivo
    Luigi Strizzi
    Mammary Biology and Tumorigenesis Laboratory, NCI CCR, 37 Convent Drive, Building 37, Bethesda, MD 20892, USA
    J Cell Sci 118:4633-43. 2005
    ..Human and mouse Cripto-1 induce proliferation, migration, invasion and colony formation by epithelial cells in 3D matrices...
  3. pmc Overexpression of human Cripto-1 in transgenic mice delays mammary gland development and differentiation and induces mammary tumorigenesis
    Youping Sun
    Tumor Growth Factor Section, Mammary Biology and Tumorigenesis Laboratory, National Cancer Institute, Bethesda, MD 20892, USA
    Am J Pathol 167:585-97. 2005
    Overexpression of Cripto-1 has been reported in several types of human cancers including breast cancer...
  4. ncbi Cripto in tumors and embryo development
    M G Persico
    International Institute of Genetics and Biophysics, CNR, Via G Marconi 12, 80125 Naples, Italy
    Biochim Biophys Acta 1552:87-93. 2001
  5. ncbi Cripto: a tumor growth factor and more
    Eileen D Adamson
    La Jolla Cancer Research Center, The Burnham Institute, La Jolla, California 92037, USA
    J Cell Physiol 190:267-78. 2002
    b>Cripto, a growth factor with an EGF-like domain, and the first member of the EGF-CFC family of genes to be sequenced and characterized, contributes to deregulated growth of cancer cells...
  6. ncbi Role of the EGF-CFC gene cripto in cell differentiation and embryo development
    Gabriella Minchiotti
    International Institute of Genetics and Biophysics, CNR, Via Marconi 12, 80125 Naples, Italy
    Gene 287:33-7. 2002
    ..b>Cripto is the founder member of the EGF-CFC family initially related to the epidermal growth factor (EGF); its expression ..
  7. pmc Dual roles of Cripto as a ligand and coreceptor in the nodal signaling pathway
    Yu Ting Yan
    Center for Advanced Biotechnology and Medicine and Department of Pediatric, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    Mol Cell Biol 22:4439-49. 2002
    The EGF-CFC gene Cripto encodes an extracellular protein that has been implicated in the signaling pathway for the transforming growth factor beta (TGF beta) ligand Nodal...
  8. ncbi The Foxh1-dependent autoregulatory enhancer controls the level of Nodal signals in the mouse embryo
    Dominic P Norris
    Department of Molecular and Cellular Biology, Harvard University, The Biological Laboratories, Cambridge, MA 02138, USA
    Development 129:3455-68. 2002
    ..The feedback loop is thus essential for maintenance of Nodal signals that selectively regulate target gene expression in a temporally and spatially controlled fashion in the mouse embryo...
  9. pmc Nodal-dependent Cripto signaling promotes cardiomyogenesis and redirects the neural fate of embryonic stem cells
    Silvia Parisi
    Institute of Genetics and Biophysics, Adriano Buzzati Traverso, Consiglio Naziolale delle Ricerche, Naples, Italy
    J Cell Biol 163:303-14. 2003
    ..We have investigated the role of Cripto, an EGF-CFC factor, in the earliest stages of cardiomyogenesis...
  10. ncbi Anterior neural plate regionalization in cripto null mutant mouse embryos in the absence of node and primitive streak
    Giovanna L Liguori
    Institute of Genetics and Biophysics A Buzzati Traverso, CNR, Via Guglielmo Marconi 12, 80125 Naples, Italy
    Dev Biol 264:537-49. 2003
    ..Mouse embryos homozygous for null mutation in the cripto gene die at about 9.0 days postcoitum (d.p.c.) and fail to gastrulate and to form the node (the primary organizer)...
  11. ncbi Maternal wnt11 activates the canonical wnt signaling pathway required for axis formation in Xenopus embryos
    Qinghua Tao
    Division of Developmental Biology, Cincinnati Children s Research Foundation, 3333 Burnet Avenue, Cincinnati, Ohio 45229, USA
    Cell 120:857-71. 2005
    ..Second, we show that activation requires the glycosyl transferase X.EXT1. Third, we find that the EGF-CFC protein, FRL1, is also essential and interacts with Wnt11 to activate canonical Wnt signaling...
  12. ncbi Human Cripto-1 overexpression in the mouse mammary gland results in the development of hyperplasia and adenocarcinoma
    Christian Wechselberger
    Tumor Growth Factor Section, Mammary Biology and Tumorigenesis Laboratory, National Cancer Institute, Bethesda, MD 20892, USA
    Oncogene 24:4094-105. 2005
    Human Cripto-1 (CR-1) is overexpressed in approximately 80% of human breast, colon and lung carcinomas. Mouse Cr-1 upregulation is also observed in a number of transgenic (Tg) mouse mammary tumors...
  13. ncbi Forebrain and midbrain regions are deleted in Otx2-/- mutants due to a defective anterior neuroectoderm specification during gastrulation
    D Acampora
    International Institute of Genetics and Biophysics CNR, Naples, Italy
    Development 121:3279-90. 1995
    ....
  14. ncbi Non-cell-autonomous role for Cripto in axial midline formation during vertebrate embryogenesis
    Jianhua Chu
    Center for Advanced Biotechnology and Medicine and Departments of Pediatrics, UMDNJ Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    Development 132:5539-51. 2005
    ..co-receptors for Nodal; by contrast, cell culture data have suggested that the mammalian EGF-CFC protein Cripto can act as a secreted signaling factor...
  15. ncbi The Vg1-related protein Gdf3 acts in a Nodal signaling pathway in the pre-gastrulation mouse embryo
    Canhe Chen
    Center for Advanced Biotechnology and Medicine and Department of Pediatrics, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    Development 133:319-29. 2006
    ..Thus, in cell culture, Gdf3 signaling requires the EGF-CFC co-receptor Cripto and can be inhibited by Lefty antagonists...
  16. pmc Cripto binds transforming growth factor beta (TGF-beta) and inhibits TGF-beta signaling
    Peter C Gray
    Clayton Foundation Laboratories for Peptide Biology, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Mol Cell Biol 26:9268-78. 2006
    b>Cripto is a developmental oncoprotein and a member of the epidermal growth factor-Cripto, FRL-1, Cryptic family of extracellular signaling molecules...
  17. ncbi Distinct and cooperative roles of mammalian Vg1 homologs GDF1 and GDF3 during early embryonic development
    Olov Andersson
    Division of Molecular Neurobiology, Department of Neuroscience, Karolinska Institutet, S 17177 Stockholm, Sweden
    Dev Biol 311:500-11. 2007
    ..signaling can be mediated by the type I receptor ALK4, type II receptors ActRIIA and ActRIIB, and the co-receptor Cripto to activate Smad-dependent reporter genes...
  18. pmc GRP78 and Cripto form a complex at the cell surface and collaborate to inhibit transforming growth factor beta signaling and enhance cell growth
    Gidi Shani
    Clayton Foundation Laboratories for Peptide Biology, The Salk Institute, La Jolla, CA, 92037, USA
    Mol Cell Biol 28:666-77. 2008
    b>Cripto is a multifunctional cell surface protein with important roles in vertebrate embryogenesis and the progression of human tumors...
  19. doi Cripto-independent Nodal signaling promotes positioning of the A-P axis in the early mouse embryo
    Giovanna L Liguori
    IBB Institute for Biotechnology and Bioengineering, Centro de Biomedicina Molecular e Estrutural, Universidade do Algarve, Campus de Gambelas, 8005 135 Faro, Portugal
    Dev Biol 315:280-9. 2008
    ..However, the extent to which Nodal activity depends on EGF-CFC proteins is still debated. Cripto is the earliest EGF-CFC gene expressed during mouse embryogenesis and is involved in both A-P axis orientation and ..
  20. doi Characterization of the functional properties of the neuroectoderm in mouse Cripto(-/-) embryos showing severe gastrulation defects
    Giovanna L Liguori
    Institute of Genetics and Biophysics A Buzzati Traverso, CNR, Via Pietro Castellino 111, Naples 80131, Italy
    Int J Dev Biol 53:549-57. 2009
    ..Mouse Cripto(-/-) embryos could potentially help settle this debate because they lack almost all embryonic endoderm and ..
  21. ncbi Nodal signalling in the epiblast patterns the early mouse embryo
    J Brennan
    Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, Massachusetts 02138, USA
    Nature 411:965-9. 2001
    ..Our experiments show that proximal-distal and subsequent anterior-posterior polarity of the pregastrulation embryo result from reciprocal cell-cell interactions between the epiblast and the two extra-embryonic tissues...
  22. ncbi Nodal signals to Smads through Cripto-dependent and Cripto-independent mechanisms
    C Yeo
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Mol Cell 7:949-57. 2001
    ..We have investigated the role of Cripto, an EGF-CFC factor, in Nodal signaling...
  23. ncbi Abrogation of the Cripto gene in mouse leads to failure of postgastrulation morphogenesis and lack of differentiation of cardiomyocytes
    C Xu
    The Burnham Institute, La Jolla Cancer Research Center, N Torrey Pines Road, La Jolla, CA 92037, USA
    Development 126:483-94. 1999
    b>Cripto-1(Cr1) protein encoded by the tdgf1 gene, is a secreted growth factor that is expressed early in embryonic development and is re-expressed in some tumors of the breast and colon...
  24. ncbi Cripto is required for correct orientation of the anterior-posterior axis in the mouse embryo
    J Ding
    Center for Advanced Biotechnology and Medicine and Dept of Pediatrics, UMDNJ Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    Nature 395:702-7. 1998
    ..Here we show that correct localization of both head- and trunk-organizing centres requires Cripto, a putative signalling molecule that is a member of the EGF-CFC gene family...
  25. ncbi A differential display strategy identifies Cryptic, a novel EGF-related gene expressed in the axial and lateral mesoderm during mouse gastrulation
    M M Shen
    Department of Genetics, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA, USA
    Development 124:429-42. 1997
    ..We named this gene Cryptic, based on its predicted protein sequence similarity with Cripto, which encodes an EGF-related growth factor...
  26. pmc Molecular characterization of a gene of the 'EGF family' expressed in undifferentiated human NTERA2 teratocarcinoma cells
    A Ciccodicola
    International Institute of Genetics and Biophysics, CNR, Naples, Italy
    EMBO J 8:1987-91. 1989
    ..Introduction of the cDNA under the control of a viral LTR induces transformation of NIH3T3 cells...
  27. ncbi Membrane-anchorage of Cripto protein by glycosylphosphatidylinositol and its distribution during early mouse development
    G Minchiotti
    International Institute of Genetics and Biophysics, CNR, Via G Marconi 12, 80125, Naples, Italy
    Mech Dev 90:133-42. 2000
    b>cripto is the original member of the family of EGF-CFC genes, recently recognized as novel extracellular factors essential for vertebrate development...
  28. ncbi The murine cripto gene: expression during mesoderm induction and early heart morphogenesis
    R Dono
    International Institute of Genetics and Biophysics, CNR, Naples, Italy
    Development 118:1157-68. 1993
    The murine cripto gene encodes a 171-aminoacid epidermal growth factor-related protein, with 93% similarity to its human counterpart in the 'EGF-like' domain...
  29. ncbi Specific arrest of cardiogenesis in cultured embryonic stem cells lacking Cripto-1
    C Xu
    Burnham Institute, La Jolla Cancer Research Center, California 92037, USA
    Dev Biol 196:237-47. 1998
    ..Here we describe the involvement of a growth factor with an EGF-like domain, Cripto-1 (Cr-1), in cardiac differentiation...
  30. ncbi The nodal precursor acting via activin receptors induces mesoderm by maintaining a source of its convertases and BMP4
    Nadav Ben-Haim
    Ecole Polytechnique Fédérale de Lausanne EPFL ISREC, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Dev Cell 11:313-23. 2006
    ..Based on mathematical modeling, we discuss how these sequential loops control cell fate...
  31. ncbi Context-dependent neuronal differentiation and germ layer induction of Smad4-/- and Cripto-/- embryonic stem cells
    Kai Christian Sonntag
    Udall Parkinson s Disease Research Center of Excellence, McLean Hospital Harvard Medical School, Belmont, MA 02478, USA
    Mol Cell Neurosci 28:417-29. 2005
    ..differentiated mouse embryonic stem (ES) cells with deletion of the TGF-beta pathway-related factors Smad4 or Cripto exhibited increased numbers of neurons...
  32. doi Epiblast-specific loss of HCF-1 leads to failure in anterior-posterior axis specification
    Shilpi Minocha
    Center for Integrative Genomics, Genopode, University of Lausanne, 1015 Lausanne, Switzerland
    Dev Biol 418:75-88. 2016
    ..We note that the pattern of Hcfc1(epiKO/Y) lethality displays many similarities to loss of β-catenin function. These results reveal essential new roles for HCF-1 in early embryonic cell proliferation and development. ..
  33. pmc Foxh1 recruits Gsc to negatively regulate Mixl1 expression during early mouse development
    Luisa Izzi
    Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada
    EMBO J 26:3132-43. 2007
    ..As Gsc is itself induced in a Foxh1-dependent manner, we propose that Foxh1 initiates positive and negative transcriptional circuits to refine cell fate decisions during gastrulation...
  34. ncbi Detection and location of amphiregulin and Cripto-1 expression in the developing postnatal mouse mammary gland
    N J Kenney
    La Jolla Cancer Research Foundation, California 92037, USA
    Mol Reprod Dev 41:277-86. 1995
    Amphiregulin (Ar) and Cripto-1 (Cr-1) are growth promoting peptides that share amino acid sequence homology with epidermal growth factor (EGF)...
  35. ncbi Regulation of human Cripto-1 gene expression by TGF-beta1 and BMP-4 in embryonal and colon cancer cells
    Mario Mancino
    Tumor Growth Factor Section, Mammary Biology and Tumorigenesis Laboratory, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20832, USA
    J Cell Physiol 215:192-203. 2008
    Human Cripto-1 (CR-1) is a cell membrane protein that is overexpressed in several different types of human carcinomas. In the present study we investigated the mechanisms that regulate the expression of CR-1 gene in cancer cells...
  36. doi Pivotal roles for eomesodermin during axis formation, epithelium-to-mesenchyme transition and endoderm specification in the mouse
    Sebastian J Arnold
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
    Development 135:501-11. 2008
    ..Collectively, our experiments establish that Eomes is a key regulator of anteroposterior axis formation, EMT and definitive endoderm specification in the mouse...
  37. doi Cripto-1 alters keratinocyte differentiation via blockade of transforming growth factor-beta1 signaling: role in skin carcinogenesis
    Anjali Shukla
    Laboratory of Cancer Biology and Genetics, National Cancer Institute, Bethesda, Maryland, USA
    Mol Cancer Res 6:509-16. 2008
    b>Cripto-1 is an epidermal growth factor-Cripto/FRL1/Cryptic family member that plays a role in early embryogenesis as a coreceptor for Nodal and is overexpressed in human tumors...
  38. pmc The microenvironment patterns the pluripotent mouse epiblast through paracrine Furin and Pace4 proteolytic activities
    Daniel Mesnard
    Ecole Polytechnique Fédérale de Lausanne EPFL SV ISREC, CH 1015 Lausanne, Switzerland
    Genes Dev 25:1871-80. 2011
    ..Adding cell-cell communication to the pleiotropic portfolio of these proteases provides a new framework to study proprotein processing also in other relevant contexts...
  39. doi Cripto regulates hematopoietic stem cells as a hypoxic-niche-related factor through cell surface receptor GRP78
    Kenichi Miharada
    Department for Molecular Medicine and Gene Therapy, Lund Strategic Center for Stem Cell Biology, Lund University, Sweden
    Cell Stem Cell 9:330-44. 2011
    ..Here we demonstrate that Cripto and its receptor GRP78 are important regulators of HSCs in the niche...
  40. pmc The T-box transcription factor Eomesodermin is essential for AVE induction in the mouse embryo
    Sonja Nowotschin
    Developmental Biology Program, Sloan Kettering Institute, New York, New York 10065, USA
    Genes Dev 27:997-1002. 2013
    ..Thus, Eomes function in the visceral endoderm (VE) initiates an instructive transcriptional program controlling AP identity...
  41. doi Analysis of Cripto expression during mouse cardiac myocyte differentiation
    Jiu Zhen Jin
    Department of Molecular, Cellular and Craniofacial Biology and Birth Defects Center, University of Louisville, Louisville, KY, USA
    Int J Dev Biol 57:793-7. 2013
    ..In this study, we have examined the expression of the mouse Cripto gene and the lineage of Cripto-expressing cells, focusing on its relationship with cardiac myocyte differentiation...
  42. pmc Cripto haploinsufficiency affects in vivo colon tumor development
    Emilia Giorgio
    Institute of Genetics and Biophysics Adriano Buzzati Traverso IGB, Consiglio Nazionale delle Ricerche CNR, 80131 Naples, Italy
    Int J Oncol 45:31-40. 2014
    ..b>Cripto (also called Teratocarcinoma-derived growth factor), the original member of the vertebrate EGF-CFC family, plays a ..
  43. pmc Cripto-1 as a novel therapeutic target for triple negative breast cancer
    Nadia P Castro
    Tumor Growth Factor Section, Mouse Cancer Genetics Program, National Cancer Institute, Frederick, MD, USA
    Oncotarget 6:11910-29. 2015
    ..b>Cripto-1, an embryonic stem cell marker, was present in spindle-like areas and its promoter showed activity in primary ..
  44. ncbi Conversion of threonine 757 to valine enhances Stat5a transactivation potential
    P M Gowri
    Graduate Center for Toxicology, University of Kentucky, Lexington 40536 0305, USA
    J Biol Chem 276:10485-91. 2001
    ..The results suggest that Thr(757) modulates the transactivation potential of Stat5 by a mechanism(s) that is dependent on the formation of Stat5 dimers and/or their nuclear translocation...
  45. ncbi Visceral endoderm mediates forebrain development by suppressing posteriorizing signals
    C Kimura
    Department of Morphogenesis, Institute of Molecular Embryology and Genetics, Kumamoto University, Honjo 2 2 1, Kumamoto, 860 0811, Japan
    Dev Biol 225:304-21. 2000
    ..These results suggest that distal visceral endoderm cells move to the future anterior side to generate a prospective forebrain territory indirectly, by preventing posteriorizing signals...
  46. ncbi Mutation of the novel gene Tmie results in sensory cell defects in the inner ear of spinner, a mouse model of human hearing loss DFNB6
    Kristina L Mitchem
    Department of Otolaryngology Kresge Hearing Research Institute, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Hum Mol Genet 11:1887-98. 2002
    ..The spinner mutant is thus a valuable model for insight into mechanisms of human deafness and development of sensory cell function...
  47. pmc Cripto regulates skeletal muscle regeneration and modulates satellite cell determination by antagonizing myostatin
    Ombretta Guardiola
    Stem Cell Fate Laboratory, Institute of Genetics and Biophysics Adriano Buzzati Traverso, Consiglio Nazionale delle Ricerche, 80131 Naples, Italy
    Proc Natl Acad Sci U S A 109:E3231-40. 2012
    ..Here, we show that Cripto, a regulator of early embryogenesis, is a novel regulator of muscle regeneration and satellite cell progression ..
  48. pmc Removal of maternal retinoic acid by embryonic CYP26 is required for correct Nodal expression during early embryonic patterning
    Masayuki Uehara
    Developmental Genetics Group, Graduate School of Frontier Biosciences, Osaka University, Osaka, Japan
    Genes Dev 23:1689-98. 2009
    ..These observations suggest that maternal RA must be removed by embryonic CYP26 for correct Nodal expression during embryonic patterning...
  49. ncbi Whole-embryo culture of E5.5 mouse embryos: development to the gastrulation stage
    Shigeto Miura
    Molecular Developmental Biology Section, Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Genesis 37:38-43. 2003
    ..Although cultured embryos tended to grow a larger extraembryonic portion, more than 80% of them developed the primitive streak and induce mesoderm, which corresponds to the mid-streak stage...
  50. ncbi Mesd encodes an LRP5/6 chaperone essential for specification of mouse embryonic polarity
    Jen Chih Hsieh
    Department of Biochemistry and Cell Biology, Center for Developmental Genetics, State University of New York, Stony Brook, Stony Brook, NY 11794, USA
    Cell 112:355-67. 2003
    ....
  51. ncbi Wnt3 signaling in the epiblast is required for proper orientation of the anteroposterior axis
    Jeffery R Barrow
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Dev Biol 312:312-20. 2007
    ....
  52. ncbi Expression of epidermal growth factor family gene members in early mouse development
    S E Johnson
    Wistar Institute, Philadelphia, Pennsylvania 19104
    Dev Dyn 201:216-26. 1994
    Transcription of four members of the epidermal growth factor (EGF) family, EGF, TGF-alpha, Amphiregulin, and Cripto, was investigated in the ovulated unfertilized egg and preimplantation embryo using cDNA libraries...
  53. pmc Cripto promotes A-P axis specification independently of its stimulatory effect on Nodal autoinduction
    Daniela D'Andrea
    Stem Cell Fate Laboratory, Institute of Genetics and Biophysics A Buzzati Traverso, Consiglio Nazionale delle Ricerche, 80131 Naples, Italy
    J Cell Biol 180:597-605. 2008
    The EGF-CFC gene cripto governs anterior-posterior (A-P) axis specification in the vertebrate embryo. Existing models suggest that Cripto facilitates binding of Nodal to an ActRII-activin-like kinase (ALK) 4 receptor complex...
  54. ncbi Extraembryonic proteases regulate Nodal signalling during gastrulation
    Séverine Beck
    Developmental Biology Group, Swiss Institute for Experimental Cancer Research ISREC, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Nat Cell Biol 4:981-5. 2002
    ..growth factor-beta (TFG-beta) that is expressed in the epiblast and visceral endoderm, and its co-receptor Cripto, which is induced downstream of Nodal...
  55. doi Man1, an inner nuclear membrane protein, regulates left-right axis formation by controlling nodal signaling in a node-independent manner
    Akihiko Ishimura
    The 21st Century Center of Excellence COE Program, Akita University, Akita, Japan
    Dev Dyn 237:3565-76. 2008
    ..These results suggest that Man1 regulates LR asymmetry by controlling Nodal signaling in a node-independent manner...
  56. pmc Cripto recruits Furin and PACE4 and controls Nodal trafficking during proteolytic maturation
    Marie Hélène Blanchet
    Ecole Polytechnique Federale de Lausanne EPFL, Swiss Institute for Experimental Cancer Research ISREC, Epalinges, Switzerland
    EMBO J 27:2580-91. 2008
    The glycosylphosphatidylinositol (GPI)-anchored proteoglycan Cripto binds Nodal and its type I receptor Alk4 to activate Smad2,3 transcription factors, but a role during Nodal precursor processing has not been described...
  57. doi Cripto localizes Nodal at the limiting membrane of early endosomes
    Marie Hélène Blanchet
    Swiss Institute for Experimental Cancer Research ISREC, School of Life Sciences, Ecole Polytechnique Federale de Lausanne EPFL, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Sci Signal 1:ra13. 2008
    b>Cripto is a glycosylphosphatidylinositol (GPI)-anchored co-receptor of Nodal and several other transforming growth factor-beta (TGF-beta) family ligands...
  58. doi Qualitative and quantitative proteomic profiling of cripto(-/-) embryonic stem cells by means of accurate mass LC-MS analysis
    Angela Chambery
    Dipartimento di Scienze della Vita, Seconda Universita di Napoli, I 81100 Caserta, Italy
    J Proteome Res 8:1047-58. 2009
    b>Cripto is one of the key regulators of embryonic stem cells (ESCs) differentiation into cardiomyocites vs neuronal fate...
  59. ncbi Inhibition of excess nodal signaling during mouse gastrulation by the transcriptional corepressor DRAP1
    Rabah Iratni
    Howard Hughes Medical Institute and Department of Biochemistry, Division of Nucleic Acids Enzymology, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    Science 298:1996-9. 2002
    ..We propose that DRAP1 limits the spread of a morphogenetic signal by down-modulating the response to the Nodal autoregulatory loop...
  60. doi Activin promotes differentiation of cultured mouse trophoblast stem cells towards a labyrinth cell fate
    David R C Natale
    Department of Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine, The University of Calgary, Calgary, AB, Canada T2N 4N1
    Dev Biol 335:120-31. 2009
    ..Our current studies indicate that TS cells do not express the Nodal co-receptor, Cripto, and do not respond directly to active Nodal in culture...
  61. pmc Functional redundancy of EGF-CFC genes in epiblast and extraembryonic patterning during early mouse embryogenesis
    Jianhua Chu
    Department of Medicine, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY 10032, USA
    Dev Biol 342:63-73. 2010
    ..We have investigated the double null mutant phenotypes for the EGF-CFC genes Cripto and Cryptic, which encode co-receptors for Nodal, and have found that they have partially redundant functions in ..
  62. doi Oct1 regulates trophoblast development during early mouse embryogenesis
    Vittorio Sebastiano
    Max Planck Institute for Molecular Biomedicine, Department of Cell and Developmental Biology, Röntgenstrasse, 20 48149 Münster, Germany
    Development 137:3551-60. 2010
    ..Our data also suggest that Oct1 is required in the embryo proper from late gastrulation stages onwards...
  63. pmc Erk5 null mice display multiple extraembryonic vascular and embryonic cardiovascular defects
    Christopher P Regan
    Vertex Pharmaceuticals, Department of Biology, 130 Waverly Street, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 99:9248-53. 2002
    ..Together, these data define an essential role for Erk5 in cardiovascular development. Moreover, the inability of Erk5-deficient mice to form a complex vasculature suggests that Erk5 may play an important role in controlling angiogenesis...
  64. ncbi BMP type II receptor is required for gastrulation and early development of mouse embryos
    H Beppu
    Department of Biochemistry, The Cancer Institute of the Japanese Foundation for Cancer Research, Research for the Future Program, Japan Society for the Promotion of Science, 1 37 1 Kami Ikebukuro, Toshima ku, Tokyo, 170 8455, Japan
    Dev Biol 221:249-58. 2000
    ..Our results suggest that the function of BMPR-II is essential for epiblast differentiation and mesoderm induction during early mouse development...
  65. ncbi Otx2 is required for visceral endoderm movement and for the restriction of posterior signals in the epiblast of the mouse embryo
    A Perea-Gomez
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM Universite Louis Pasteur, BP163, 67404 Illkirch Cedex, C U de Strasbourg, France
    Development 128:753-65. 2001
    ....
  66. ncbi Detection and localization of Cripto-1 binding in mouse mammary epithelial cells and in the mouse mammary gland using an immunoglobulin-cripto-1 fusion protein
    Caterina Bianco
    Tumor Growth Factor Section, Basic Research Laboratory, National Cancer Institute NIH, Bldg 10, Rm 5B39, 9000 Rockville Pike, Bethesda, MD 20892, USA
    J Cell Physiol 190:74-82. 2002
    Human Cripto-1 (CR-1), a member of the epidermal growth factor-CFC (EGF-CFC) family of peptides, is expressed in the developing mouse mammary gland and can modulate mammary epithelial cell migration, branching morphogenesis and milk ..
  67. ncbi Disruption of early proximodistal patterning and AVE formation in Apc mutants
    Claire Chazaud
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, 600 University Avenue, Toronto, Ontario, M5G 1X5, Canada
    Development 133:3379-87. 2006
    ..In addition, we found that nuclear beta-catenin and other molecular markers are asymmetrically expressed by 4.5 days...
  68. ncbi Multiple roles for Nodal in the epiblast of the mouse embryo in the establishment of anterior-posterior patterning
    Cindy C Lu
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Dev Biol 273:149-59. 2004
    ....
  69. pmc The docking protein FRS2alpha is an essential component of multiple fibroblast growth factor responses during early mouse development
    N Gotoh
    Department of Pharmacology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
    Mol Cell Biol 25:4105-16. 2005
    ..These experiments underscore the critical role of FRS2alpha in mediating multiple processes during embryonic development and reveal a potential new link between FGF and Bmp4 signaling pathways in early embryogenesis...
  70. ncbi Tcf3: a transcriptional regulator of axis induction in the early embryo
    Bradley J Merrill
    Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY 10021, USA
    Development 131:263-74. 2004
    ..Taken together, these data reveal a unique requirement for Tcf3 repressor function in restricting induction of the anterior-posterior axis...
  71. ncbi Canonical Wnt signaling and its antagonist regulate anterior-posterior axis polarization by guiding cell migration in mouse visceral endoderm
    Chiharu Kimura-Yoshida
    Vertebrate Body Plan Group, RIKEN Center for Developmental Biology CDB, 2 2 3 Minatojima minami cho, Chuou ku Kobe, Hyogo 650 0047, Japan
    Dev Cell 9:639-50. 2005
    ..We propose that Wnt/beta-catenin signaling mediates A-P axis polarization by guiding cell migration toward the prospective anterior in the pregastrula mouse embryo...
  72. ncbi Dual role of the basic helix-loop-helix transcription factor scleraxis in mesoderm formation and chondrogenesis during mouse embryogenesis
    D Brown
    Department of Molecular Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75235 9148, USA
    Development 126:4317-29. 1999
    ..These results reveal an essential early role for scleraxis in mesoderm formation, as well as a later role in formation of somite-derived chondrogenic lineages, and suggest that scleraxis target genes mediate these processes...
  73. ncbi Cripto enhances the tyrosine phosphorylation of Shc and activates mitogen-activated protein kinase (MAPK) in mammary epithelial cells
    S Kannan
    Tumor Growth Factor Section, Laboratory of Tumor Immunology and Biology, NIC, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 272:3330-5. 1997
    b>Cripto-1 (CR-1), a recently discovered protein of the epidermal growth factor (EGF) family, was found to interact with a high affinity, saturable binding site(s) on HC-11 mouse mammary epithelial cells and on several different human ..
  74. ncbi Ets2 is necessary in trophoblast for normal embryonic anteroposterior axis development
    Pantelis Georgiades
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada
    Development 133:1059-68. 2006
    ..This study provides new insights about the genetic and cellular basis of the patterning role and development of the early trophoblast...
  75. ncbi The mouse embryo autonomously acquires anterior-posterior polarity at implantation
    Katsuyoshi Takaoka
    Developmental Genetics Group, Graduate School of Frontier Biosciences, Osaka University and Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation, 1 3 Yamada oka, Suita, Osaka 565 0871, Japan
    Dev Cell 10:451-9. 2006
    ..This asymmetry in molecular patterning of the mouse embryo pushes back the origin of the A-P body axis to the peri-implantation stage...
  76. ncbi Axis specification and morphogenesis in the mouse embryo require Nap1, a regulator of WAVE-mediated actin branching
    Andrew S Rakeman
    Developmental Biology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10021, USA
    Development 133:3075-83. 2006
    ..Thus, the Nap1 mutant phenotypes define the crucial roles of Nap1/WAVE-mediated actin regulation in tissue organization and establishment of the body plan of the mammalian embryo...
  77. pmc Crucial roles of Foxa2 in mouse anterior-posterior axis polarization via regulation of anterior visceral endoderm-specific genes
    Chiharu Kimura-Yoshida
    Department of Molecular Embryology, Osaka Medical Center and Research Institute for Maternal and Child Health, Osaka Prefectural Hospital Organization, Murodo cho, Izumi, Osaka 594 1101, Japan
    Proc Natl Acad Sci U S A 104:5919-24. 2007
    ..These findings provide profound insights into conserved roles of Foxa2 transcription factors in anterior specification throughout the evolution of the chordate body plan...
  78. ncbi Sulfated glycosaminoglycans are necessary for Nodal signal transmission from the node to the left lateral plate in the mouse embryo
    Shinya Oki
    Developmental Genetics Group, Graduate School of Frontier Biosciences, Osaka University, and CREST, Japan Science and Technology Corporation JST Yamada oka, Suita, Osaka 565 0871, Japan
    Development 134:3893-904. 2007
    ..Inhibition of sulfated GAG biosynthesis prevents Nodal expression in the LPM. These data suggest that Nodal produced at the node might travel directly to the LPM via interaction with sulfated GAGs...
  79. ncbi BMP signalling inhibits premature neural differentiation in the mouse embryo
    Aida Di-Gregorio
    Molecular Embryology Group, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London W12 ONN, UK
    Development 134:3359-69. 2007
    ..Together, our results demonstrate that inhibition of BMP signalling has a central role during neural induction in mammals and suggest that FGFs do not act as neural inducers in the post-implantation mouse embryo...
  80. ncbi Beta-catenin regulates Cripto- and Wnt3-dependent gene expression programs in mouse axis and mesoderm formation
    Markus Morkel
    Max Delbrueck Center for Molecular Medicine, Robert Roessle Strasse 10, 13125 Berlin, Germany
    Development 130:6283-94. 2003
    Gene expression profiling of beta-catenin, Cripto and Wnt3 mutant mouse embryos has been used to characterise the genetic networks that regulate early embryonic development...
  81. pmc Sox17 is essential for the specification of cardiac mesoderm in embryonic stem cells
    Yu Liu
    Center for Cardiovascular Development, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 104:3859-64. 2007
    ..Sox17 short-hairpin RNA blocks cardiac myogenesis non-cell autonomously and impairs the induction of Hex, a homeodomain transcription factor that is known to be required for the production of endoderm-derived heart-inducing factors...
  82. ncbi Characterization of the mouse Tdgf1 gene and Tdgf pseudogenes
    G Liguori
    International Institute of Genetics and Biophysics, CNR, Via Marconi 10, 80125 Naples, Italy
    Mamm Genome 7:344-8. 1996
    b>Cripto protein is a member of the "EGF family" of growth factors present in colon tumors and in human and mouse undifferentiated teratocarcinoma cells...
  83. pmc Control of early anterior-posterior patterning in the mouse embryo by TGF-beta signalling
    Elizabeth J Robertson
    Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
    Philos Trans R Soc Lond B Biol Sci 358:1351-7; discussion 1357. 2003
    ....
  84. pmc Netrin-1 can affect morphogenesis and differentiation of the mouse mammary gland
    Luigi Strizzi
    Mammary Biology and Tumorigenesis Laboratory, National Cancer Institute, Bethesda, Maryland 20892, USA
    J Cell Physiol 216:824-34. 2008
    Netrin-1 has been shown to regulate the function of the EGF-like protein Cripto-1 (Cr-1) and affect mammary gland development...
  85. pmc Cripto-1 is required for hypoxia to induce cardiac differentiation of mouse embryonic stem cells
    Caterina Bianco
    Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA
    Am J Pathol 175:2146-58. 2009
    b>Cripto-1 is a membrane-bound protein that is highly expressed in embryonic stem cells and in human tumors...
  86. pmc Activation of a Nodal-independent signaling pathway by Cripto-1 mutants with impaired activation of a Nodal-dependent signaling pathway
    Caterina Bianco
    Mammary Biology and Tumorigenesis Laboratory, NCI NIH, 37 Convent Drive, Building 37 room 1112, Bethesda, MD 20892, USA
    FEBS Lett 582:3997-4002. 2008
    b>Cripto-1, a co-receptor for Nodal, can activate Nodal-dependent and Nodal-independent signaling pathways...
  87. ncbi Mapping of the mouse Tdgf1 gene and Tdgf pseudogenes
    G Liguori
    International Institute of Genetics and Biophysics, CNR, Via Guglielmo Marconi, 12, 80125 Naples, Italy
    Mamm Genome 8:502-5. 1997
    Teratocarcinoma-derived growth factor-1 (Tdgf1), a member of the "EGF family" of growth factors, is expressed during mouse gastrulation in the forming mesoderm and later in the truncus arteriosus of the developing heart...
  88. pmc Targeted deletion of mek5 causes early embryonic death and defects in the extracellular signal-regulated kinase 5/myocyte enhancer factor 2 cell survival pathway
    Xin Wang
    University of Manchester, The Michael Smith Building, Oxford Road, Manchester M13 9PT, United Kingdom
    Mol Cell Biol 25:336-45. 2005
    ..Overall, this is the first study to rigorously establish the role of MEK5 in vivo as an activator of ERK5 and as an essential regulator of cell survival that is required for normal embryonic development...
  89. pmc Ecsit is required for Bmp signaling and mesoderm formation during mouse embryogenesis
    Changchun Xiao
    Section of Immunobiology, Howard Hughes Medical Institute, New Haven, CT 06520, USA
    Genes Dev 17:2933-49. 2003
    ..Therefore, these results show that Ecsit functions as an essential component in two important signal transduction pathways and establishes a novel role for Ecsit as a cofactor for Smad proteins in the Bmp signaling pathway...
  90. ncbi Loss of the extraembryonic ectoderm in Elf5 mutants leads to defects in embryonic patterning
    Martyn Donnison
    AgResearch Crown Research Institute, Ruakura Campus, East Street, Hamilton 2001, New Zealand
    Development 132:2299-308. 2005
    ..Embryos without ExE tissue are able to form the anterior visceral endoderm but fail to undergo gastrulation, demonstrating an essential role for the ExE in embryonic patterning during a defined window of development...
  91. ncbi Otx2 is required to respond to signals from anterior neural ridge for forebrain specification
    E Tian
    Department of Morphogenesis, Kumamoto University, Honjo 2 2 1, Kumamoto, 860 0811, Japan
    Dev Biol 242:204-23. 2002
    ..These results further suggest that Otx2 dosage may be crucial in the neural plate with respect to response to inductive signals primarily from the ANR for forebrain specification...
  92. doi Left-asymmetric expression of Galanin in the linear heart tube of the mouse embryo is independent of the nodal co-receptor gene cryptic
    Axel Schweickert
    University of Hohenheim, Institute of Zoology, Stuttgart, Germany
    Dev Dyn 237:3557-64. 2008
    ..Surprisingly, Pitx2c was found to be expressed in 50% of cryptic mutant hearts as well, suggesting that some aspects of asymmetric gene expression in the heart are independent of cryptic...
  93. pmc Effects of thioredoxin reductase-1 deletion on embryogenesis and transcriptome
    Alla A Bondareva
    VMB, Molecular Biosciences, 960 Technology Blvd, Montana State University, Bozeman, MT 59718, USA
    Free Radic Biol Med 43:911-23. 2007
    ..Conserved responses to Txnrd1 disruption likely allowed proliferation and limited differentiation of the mutant embryo cells...
  94. ncbi Inhibition of activin signaling induces pancreatic epithelial cell expansion and diminishes terminal differentiation of pancreatic beta-cells
    You Qing Zhang
    Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
    Diabetes 53:2024-33. 2004
    ..Interestingly, the expression of endogenous cellular inhibitors of activin signaling, follistatin and Cripto, were also found to be augmented...
  95. doi Sall4 isoforms act during proximal-distal and anterior-posterior axis formation in the mouse embryo
    Nikolas Uez
    Helmholtz Center Munich, Institute of Developmental Genetics, Ingolstaedter Landstrasse 1, Munich, Neuherberg, Germany
    Genesis 46:463-77. 2008
    ..This observation was supported through genetic interaction with beta-catenin mutants, since compound heterozygous mutants recapitulated the defects of Wnt3a mutants in posterior development...

Research Grants3

  1. Mechanisms of activin antagonism
    Peter Gray; Fiscal Year: 2004
    ..Together, these experiments will further elucidate mechanisms of activating antagonism to provide a basis for the development of tools and reagents to treat pituitary and reproductive disorders. ..
  2. The role of cell polarity in vertebrate limb outgrowth
    Jeffery Barrow; Fiscal Year: 2007
    ..Furthermore he will examine the epistatic relationship between Fgf and Wnt/PCP signaling in regulating cell polarity. [unreadable] [unreadable] [unreadable]..