Genomes and Genes
Gene Symbol: Tcrb
Description: T cell receptor beta chain
Alias: TCRbeta, Tib
Publications131 found, 100 shown here
- Onset of TCR-beta gene rearrangement and role of TCR-beta expression during CD3-CD4-CD8- thymocyte differentiationD I Godfrey
DNAX Research Institute, Palo Alto, CA 94304
J Immunol 152:4783-92. 1994....
- Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15-deficient miceM K Kennedy
Immunex Corporation, Seattle, Washington 98101, USA
J Exp Med 191:771-80. 2000..Moreover, the ability to rescue lymphoid defects in IL-15(-/-) mice by IL-15 administration represents a powerful means by which to further elucidate the biological roles of this cytokine...
- Mature follicular dendritic cell networks depend on expression of lymphotoxin beta receptor by radioresistant stromal cells and of lymphotoxin beta and tumor necrosis factor by B cellsR Endres
Institute of Medical Microbiology, Immunology and Hygiene, Technical University of Munich, D 81675 Munich, Germany
J Exp Med 189:159-68. 1999..Thus, development of splenic FDC networks depends on expression of LTbeta and TNF by B lymphocytes and LTbetaR by radioresistant stromal cells...
- The CD3gamma chain is essential for development of both the TCRalphabeta and TCRgammadelta lineagesM C Haks
Division of Immunology, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Huis, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
EMBO J 17:1871-82. 1998..selectively lacking expression of CD3gamma, in which expression of CD3delta, CD3epsilon, CD3zeta, pTalpha and TCRbeta remained undisturbed. Thus, all components for composing a pre-TCR are available, with the exception of CD3gamma...
- CD3 epsilon-mediated signals rescue the development of CD4+CD8+ thymocytes in RAG-2-/- mice in the absence of TCR beta chain expressionY Shinkai
Howard Hughes Medical Institute, Boston, MA
Int Immunol 6:995-1001. 1994..Together, these data strongly indicate that TCR beta chain-mediated developmental signals are transduced by CD3 components and provide potential insights into mechanisms by which TCR beta chain expression may effect this process...
- Id2-, RORgammat-, and LTbetaR-independent initiation of lymphoid organogenesis in ocular immunityTakahiro Nagatake
Division of Mucosal Immunology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Minato ku, Tokyo 108 8639, Japan
J Exp Med 206:2351-64. 2009..Thus, TALT shares immunological features with MALT but has a distinct tissue genesis mechanism and plays a key role in ocular immunity...
- Functions of TCR and pre-TCR subunits: lessons from gene ablationB Malissen
Centre d Immunologie, INSERM CNRS de Marseille Luminy, France
Curr Opin Immunol 8:383-93. 1996..By activating intracellular effectors, the CD3 subunits probably modulate gene expression profiles and drive the maturing alpha beta T cells through a precise developmental sequence...
- Structure and function of the pre-T cell receptorH von Boehmer
Institut Necker, INSERM 373, Paris, France
Annu Rev Immunol 15:433-52. 1997..The function of the pre-TCR cannot be fully assumed by an alpha beta TCR that is expressed abnormally early in T cell development...
- Alternative and classical NF-kappa B signaling retain autoreactive B cells in the splenic marginal zone and result in lupus-like diseaseThomas Enzler
Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA
Immunity 25:403-15. 2006..Thus, both classical and alternative NF-kappaB signaling are important for development of lupus-like disease associated with BAFF overproduction. The same mechanisms may be involved in the pathogenesis of human SLE...
- Foxp3-dependent programme of regulatory T-cell differentiationMarc A Gavin
Department of Immunology, University of Washington, Seattle, Washington 98195, USA
Nature 445:771-5. 2007..This adaptation includes Foxp3-dependent repression of cyclic nucleotide phosphodiesterase 3B, affecting genes responsible for Tr cell homeostasis...
- Mutations in T-cell antigen receptor genes alpha and beta block thymocyte development at different stagesP Mombaerts
Howard Hughes Medical Institute, Center for Cancer Research, Cambridge, Massachusetts
Nature 360:225-31. 1992..TCR-alpha is irrelevant in these developmental processes. The development of gamma delta T cells does not depend on either TCR-alpha or TCR-beta...
- Creation of a large genomic deletion at the T-cell antigen receptor beta-subunit locus in mouse embryonic stem cells by gene targetingP Mombaerts
Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge 02139
Proc Natl Acad Sci U S A 88:3084-7. 1991....
- Induction by antigen of intrathymic apoptosis of CD4+CD8+TCRlo thymocytes in vivoK M Murphy
Department of Pathology, Washington University School of Medicine, St Louis, MO 63110
Science 250:1720-3. 1990..Apoptosis of cortical thymocytes can be seen within 20 hours of treatment. These results provide direct evidence for the in vivo role of apoptosis in the development of antigen-induced tolerance...
- Tolerance induction in double specific T-cell receptor transgenic mice varies with antigenH Pircher
Department of Experimental Pathology, University Hospital, Zurich, Switzerland
Nature 342:559-61. 1989..Thus the same transgenic TCR-expressing T cells may be tolerized at different stages of their maturation and at different locations in the thymus depending on the antigen involved...
- Incomplete T cell receptor V beta allelic exclusion and dual V beta-expressing cellsD Balomenos
Department of Immunology, Scripps Research Institute, La Jolla, CA 92037, USA
J Immunol 155:3308-12. 1995..These findings may have important implications for TCR selection and specificity, age-related repertoire changes, and autoimmune disease pathogenesis...
- Analysis and expression of a cloned pre-T cell receptor geneC Saint-Ruf
Unité INSERM 373, Institut Necker, Paris, France
Science 266:1208-12. 1994..Identification of the pT alpha gene represents an essential step in the structure-function analysis of the pre-TCR complex...
- Spontaneous development of inflammatory bowel disease in T cell receptor mutant miceP Mombaerts
Howard Hughes Medical Institute, Department of Biology Massachusetts Institute of Technology Cambridge 02139
Cell 75:274-82. 1993..IBD in the mutant mice has some of the features of the human disease ulcerative colitis. Based on these results, we suggest that dysfunction of the mucosal immune system may underly the pathogenesis of some types of IBD in humans...
- Deletion of the mouse T-cell receptor beta gene enhancer blocks alphabeta T-cell developmentG Bouvier
Centre d immunologie de Marseille Luminy, Institut National de la Santé et de la Recherche Médicale Centre National de la Recherche Scientifique, France
Proc Natl Acad Sci U S A 93:7877-81. 1996..These data formally establish the critical role played by Ebeta in cis-activation of the TCR beta locus for V(D)J recombination during alphabeta T-cell development...
- A motif within the T cell receptor alpha chain constant region connecting peptide domain controls antigen responsivenessB T Backstrom
Basel Institute for Immunology, Switzerland
Immunity 5:437-47. 1996..This conserved alpha chain connecting peptide motif might mediate the transfer of signals from the alphabeta heterodimer to the CD3/zeta complex...
- Signaling capacity of the T cell antigen receptor is negatively regulated by the PTP1C tyrosine phosphataseG Pani
Department of Medicine, University of Toronto, Ontario, Canada
J Exp Med 184:839-52. 1996....
- T cell-mediated elimination of B7.2 transgenic B cellsS Fournier
Department of Molecular and Cellular Biology, University of California at Berkeley, 94720, USA
Immunity 6:327-39. 1997..2 transgenic B cells are not eliminated, but proliferate and differentiate normally. Our findings suggest that, in the absence of high affinity ligand for the TCR, the CD28-B7.2 system participates in the regulation of B cell homeostasis...
- Early alpha beta T cell development in the thymus of normal and genetically altered miceH J Fehling
Basel Institute for Immunology, Switzerland
Curr Opin Immunol 9:263-75. 1997..Recent studies of pre-TCR function have led to a better understanding of the molecular events in early thymocyte development...
- CD3 delta deficiency arrests development of the alpha beta but not the gamma delta T cell lineageV P Dave
Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
EMBO J 16:1360-70. 1997..Absence of CD3 delta specifically blocks the thymic selection processes that mediate the transition from the double-positive to single-positive stages of development...
- Deficient positive selection of CD4 T cells in mice displaying altered repertoires of MHC class II-bound self-peptidesC E Grubin
Department of Immunology, University of Washington, Seattle 98195, USA
Immunity 7:197-208. 1997..In addition, the data suggest that T cell receptor repertoires selected in wild-type mice and in mice displaying limited spectra of self-peptides are distinct...
- B lymphocytes induce the formation of follicular dendritic cell clusters in a lymphotoxin alpha-dependent fashionY X Fu
Department of Laboratory Medicine Pathology, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Exp Med 187:1009-18. 1998..Thus, B cells themselves provide an essential signal that induces and maintains the lymphoid microenvironment essential for GC formation and class-switched Ig responses...
- Regulation of Vbeta germline transcription in RAG-deficient mice by the CD3epsilon-mediated signals: implication of Vbeta transcriptional regulation in TCR beta allelic exclusionM Senoo
Department of Molecular Oncology, Nippon Roche Research Center, Kamakura City, Kanagawa, Japan
Int Immunol 10:553-60. 1998..These data indicate that the regulation of Vbeta germline transcription by the signals through the pre-TCR complex may reflect the modulation of Vbeta accessibility to the VDJ recombinase, which contributes to TCR beta allelic exclusion...
- A mouse carrying genetic defect in the choice between T and B lymphocytesY Tokoro
Department of Immunology, University of Tsukuba, Tennodai, Japan
J Immunol 161:4591-8. 1998..Thus, tg epsilon26 mice provide a novel mouse model in that lineage choice between T and B lymphocytes is genetically defective...
- CD5 expression is developmentally regulated by T cell receptor (TCR) signals and TCR avidityH S Azzam
Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
J Exp Med 188:2301-11. 1998..Taken together, these observations suggest that the developmental regulation of CD5 in response to TCR signaling and TCR avidity represents a mechanism for fine tuning of the TCR signaling response...
- Lymphotoxin alpha/beta and tumor necrosis factor are required for stromal cell expression of homing chemokines in B and T cell areas of the spleenV N Ngo
Department of Microbiology and Immunology, University of California San Francisco, San Francisco, California 94143, USA
J Exp Med 189:403-12. 1999..Together these findings indicate that LTalpha1beta2 and TNF are required for the development and function of B and T zone stromal cells that make chemokines necessary for lymphocyte compartmentalization in the spleen...
- Organogenic role of B lymphocytes in mucosal immunityT V Golovkina
Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
Science 286:1965-8. 1999..The lack of M cells abrogated infection with a milk-borne retrovirus. Thus, in addition to secretion of antibodies and presentation of antigens, B cells are important for organogenesis of the mucosal immune barriers...
- Recombination signal sequences restrict chromosomal V(D)J recombination beyond the 12/23 ruleC H Bassing
Howard Hughes Medical Institute, Children s Hospital and Department of Genetics, Harvard Medical School and The Center for Blood Research, Boston, Massachusetts 02115, USA
Nature 405:583-6. 2000..This targeting is precise and position-independent. This additional restriction on V(D)J recombination has important implications for the regulation of variable region gene assembly and repertoire development...
- A primitive T cell-independent mechanism of intestinal mucosal IgA responses to commensal bacteriaA J MacPherson
Institute of Experimental Immunology, Universitatsspital, Schmelzbergstrasse 12, CH8091, Zurich, Switzerland
Science 288:2222-6. 2000....
- Development of dendritic epidermal T cells with a skewed diversity of gamma delta TCRs in V delta 1-deficient miceH Hara
Department of Immunology, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
J Immunol 165:3695-705. 2000....
- Innate immunity to viruses: control of vaccinia virus infection by gamma delta T cellsL K Selin
Department of Pathology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
J Immunol 166:6784-94. 2001..Thus, gammadelta T cells can be mediators of innate immunity to viruses, having a significant impact on virus replication early in infection in the presence or absence of the adaptive immune response...
- Autoreactive diabetogenic T-cells in NOD mice can efficiently expand from a greatly reduced precursor poolD V Serreze
The Jackson Laboratory, Bar Harbor, Maine 04609, USA
Diabetes 50:1992-2000. 2001..This might allow diabetogenic T-cells in NOD mice to undergo an efficient expansion before encountering antigen, which would represent an important and previously unconsidered aspect of pathogenesis...
- Comparative genomics of the human and mouse T cell receptor lociG Glusman
The Institute for Systems Biology, 4225 Roosevelt Way NE, Seattle, WA 98105, USA
Immunity 15:337-49. 2001..The genomic landscape of the TCR loci provides fundamental insights into TCR evolution as highly localized and tightly regulated gene families...
- Resident skin-specific gammadelta T cells provide local, nonredundant regulation of cutaneous inflammationMichael Girardi
Department of Dermatology and the Yale Skin Diseases Research Core Center, Yale University, New Haven, CT 06520, USA
J Exp Med 195:855-67. 2002....
- Conserved T cell receptor usage in primary and recall responses to an immunodominant influenza virus nucleoprotein epitopeKatherine Kedzierska
Department of Microbiology and Immunology, University of Melbourne, Parkville 3010, Australia
Proc Natl Acad Sci U S A 101:4942-7. 2004..Based on the length and amino acid sequences of the complementarity-determining region 3 of TCRbeta (CDR3beta) loop and associated Jbeta usage, the same dominant TCRbeta signatures were found in the blood, the ..
- Obligatory role for cooperative signaling by pre-TCR and Notch during thymocyte differentiationMaria Ciofani
Department of Immunology, University of Toronto, Sunnybrook and Women s College Health Sciences Centre, Toronto, Ontario, Canada
J Immunol 172:5230-9. 2004..Collectively, our results demonstrate an essential role for Notch receptor-ligand interactions in enabling the autonomous signaling capacity of the pre-TCR complex...
- Regulatory T cell lineage specification by the forkhead transcription factor foxp3Jason D Fontenot
Department of Immunology, University of Washington, Seattle, Washington 98195, USA
Immunity 22:329-41. 2005..Analysis of Foxp3 expression during thymic development suggests that this mechanism is not hard-wired but is dependent on TCR/MHC ligand interactions...
- Spontaneous atopic dermatitis in mice expressing an inducible thymic stromal lymphopoietin transgene specifically in the skinJane Yoo
Department of Immunology, University of Washington School of Medicine, Seattle, WA 98101, USA
J Exp Med 202:541-9. 2005..These transgenic mice demonstrate that TSLP can initiate a cascade of allergic inflammation in the skin and provide a valuable animal model for future study of this common disease...
- Regulated costimulation in the thymus is critical for T cell development: dysregulated CD28 costimulation can bypass the pre-TCR checkpointJoy A Williams
Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
J Immunol 175:4199-207. 2005..levels extremely low on immature thymocytes but increasing dramatically as CD4- CD8- cells initiate expression of TCRbeta. B7-1 and B7-2, the ligands for CD28, have a restricted distribution in the thymic cortex where immature ..
- Perisinusoidal B cells in the bone marrow participate in T-independent responses to blood-borne microbesAnnaiah Cariappa
Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02129, USA
Immunity 23:397-407. 2005..The bone marrow represents a unique type of secondary lymphoid organ in which mature B cells are strategically positioned in the path of circulating microbes...
- Cell surface recycling of internalized antigen permits dendritic cell priming of B cellsAmy Bergtold
Integrated Program in Cellular, Molecular, and Biophysical Studies, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
Immunity 23:503-14. 2005..Thus dendritic cells are equipped with both non-degradative and degradative antigen uptake pathways to facilitate antigen presentation to both B and T cells...
- Expression of rearranged TCRgamma genes in natural killer cells suggests a minor thymus-dependent pathway of lineage commitmentLinnea Lora Veinotte
Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, British Columbia, Canada, V5Z 1L3
Blood 107:2673-9. 2006..5% of neonatal and 1% of adult mouse splenic NK cells, and similar levels are detected in NK cells from TCRbeta,delta double-knockout mice, excluding the possibility of T-cell contamination...
- Stoichiometry of the murine gammadelta T cell receptorSandra M Hayes
Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
J Exp Med 203:47-52. 2006..Our results support a model of murine gammadeltaTCR stoichiometry in which there are two CD3gammaepsilon dimers for every TCRgammadelta heterodimer...
- Cutting edge: enhancement of antibody responses through direct stimulation of B and T cells by type I IFNAgnes Le Bon
The Edward Jenner Institute for Vaccine Research, Compton, Newbury, Berkshire, UK
J Immunol 176:2074-8. 2006..These results indicate that IFN-alphabetaR signaling in both B and T cells plays an important role in the stimulation of Ab responses by IFN-alphabeta...
- Local increase in thymic stromal lymphopoietin induces systemic alterations in B cell developmentAlexander Astrakhan
Department of Immunology, University of Washington School of Medicine Seattle, Washington 98195, USA
Nat Immunol 8:522-31. 2007..These observations suggest that signals mediating localized TSLP expression may modulate systemic B cell development and promote humoral autoimmunity...
- Role of CXCR5 and CCR7 in follicular Th cell positioning and appearance of a programmed cell death gene-1high germinal center-associated subpopulationNicole M Haynes
Howard Hughes Medical Institute, University of California, San Francisco, CA 94143, USA
J Immunol 179:5099-108. 2007....
- Protein kinase C theta plays a fundamental role in different types of chronic colitisKiyotaka Nagahama
Department of Pathology, Experimental Pathology, Massachusetts General Hospital, Boston, Massachusetts, USA
Gastroenterology 134:459-69. 2008..A key molecule associated with the IS is protein kinase C (PKC) theta. However, the role of PKCtheta in the pathogenesis of colitis has not fully been defined...
- Requirement for lymphoid tissue-inducer cells in isolated follicle formation and T cell-independent immunoglobulin A generation in the gutMasayuki Tsuji
Laboratory for Mucosal Immunity, Research Center for Allergy and Immunology, RIKEN Yokohama 1 7 22, Tsurumi, Yokohama, 230 0045, Japan
Immunity 29:261-71. 2008..These findings provide insight into the crosstalk between bacteria, ROR gamma t(+)LTi cells, SCs, DCs, and B cells required for ILF formation and establish a critical role of ILFs in T cell-independent IgA synthesis in gut...
- Functional overlap in the cis-acting regulation of the V(D)J recombination at the TCRbeta locusBernard Khor
Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
Mol Immunol 46:321-6. 2009..In the TCRbeta locus, accessibility of the Dbeta1-Jbeta1 gene segment cluster relies on the function of an enhancer, Ebeta, and ..
- Th17-polarized immune response in a murine model of hypersensitivity pneumonitis and lung fibrosisPhilip L Simonian
Department of Medicine, University of Colorado Denver, Denver, CO 80262, USA
J Immunol 182:657-65. 2009..In the absence of alphabeta T cells, TCRbeta(-/-) mice exposed to S...
- The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammationMeghan A Koch
Benaroya Research Institute, Seattle, Washington, USA
Nat Immunol 10:595-602. 2009....
- T cells dampen innate immune responses through inhibition of NLRP1 and NLRP3 inflammasomesGreta Guarda
Department of Biochemistry, University of Lausanne, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
Nature 460:269-73. 2009....
- The requirement for pre-TCR during thymic differentiation enforces a developmental pause that is essential for V-DJβ rearrangementKaren S Hathcock
Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
PLoS ONE 6:e20639. 2011..However, the requirement for pre-TCR signals and the exclusion of alternative stimuli such as CD28 enforce a developmental "pause" in early DN3 cells that is essential for productive TCRβ rearrangement to occur...
- Follicular regulatory T cells expressing Foxp3 and Bcl-6 suppress germinal center reactionsYeonseok Chung
Department of Immunology, Center for Cancer Immunology Research, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
Nat Med 17:983-8. 2011..These results unveil a Bcl-6-CXCR5 axis in T(reg) cells that drives the development of follicular regulatory T (T(FR)) cells that function to inhibit the germinal center reactions...
- Pathogen-specific Treg cells expand early during mycobacterium tuberculosis infection but are later eliminated in response to Interleukin-12Shahin Shafiani
Seattle Biomedical Research Institute, Seattle, WA 98109, USA
Immunity 38:1261-70. 2013..These findings have important implications for the prevention and treatment of tuberculosis and other chronic diseases in which antigen-specific Treg cells restrict immunity...
- Mouse T-cell receptor variable gene segment familiesB Arden
Paul Ehrlich Institute, Langen, Germany
Immunogenetics 42:501-30. 1995..In the mouse, most V gene segments can be grouped into subfamilies of closely related genes with significantly less similarity between different subfamilies...
- The induction of a protective response in Leishmania major-infected BALB/c mice with anti-CD40 mAbW G Ferlin
Department of Immunobiology, DNAX Research Institute, Palo Alto, CA, USA
Eur J Immunol 28:525-31. 1998..major infection and raises the possibility of utilizing this approach for vaccination strategies...
- Negative regulation of airway responsiveness that is dependent on gammadelta T cells and independent of alphabeta T cellsM Lahn
Division of Basic Immunology, Department of Medicine, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, Colorado 80206, USA
Nat Med 5:1150-6. 1999..This function of gammadelta T cells differs from previously described immune-dependent mechanisms and may reflect their interaction with innate systems of host defense...
- T cell development in TCR beta enhancer-deleted mice: implications for alpha beta T cell lineage commitment and differentiationI Leduc
Centre d immunologie de Marseille Luminy, Institut National de la Santé et de la Recherche Médicale Centre National de la Recherche Scientifique, Marseille, France
J Immunol 165:1364-73. 2000..We discuss these data with respect to the functional role of E beta in driving alpha beta T cell differentiation and the mechanism of alpha beta T lineage commitment...
- Cutting edge: germinal centers can be induced in the absence of T cellsV M Lentz
Kimmel Cancer Center and Department of Microbiology and Immunology, Jefferson Medical College, Philadelphia, PA 19107, USA
J Immunol 167:15-20. 2001..Therefore, T cells may be required for B cell differentiation processes associated with the intermediate and latter stages of the GC reaction, but they are dispensable for the induction and initial development of this response...
- Peripheral lymphoid development and function in TCR mutant miceP Mombaerts
Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge 02139
Int Immunol 6:1061-70. 1994..Natural killer cell function is not impaired in any of the mutant mice. TCR mutant mice will prove useful in dissecting differential functions of alpha beta and gamma delta T cells in vivo...
- 'Coreceptor tuning': cytokine signals transcriptionally tailor CD8 coreceptor expression to the self-specificity of the TCRJung Hyun Park
Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
Nat Immunol 8:1049-59. 2007..This dynamic interplay induces individual CD8+ T cells to express CD8 in quantities appropriate for the self-specificity of their TCR, promoting the engagement of self ligands, yet avoiding autoreactivity...
- Different composition of the human and the mouse gammadelta T cell receptor explains different phenotypes of CD3gamma and CD3delta immunodeficienciesGabrielle M Siegers
Max Planck Institute of Immunobiology and University of Freiburg, 79108 Freiburg, Germany
J Exp Med 204:2537-44. 2007..Collectively, our results indicate that the different gammadelta T cell phenotypes between CD3gamma-deficient humans and mice can be explained by differences in their gammadelta TCR composition...
- T cell receptor-alpha beta lacking the beta-chain V domain can be expressed at the cell surface but prohibits T cell maturationF Ossendorp
Division of Immunology, The Netherlands Cancer Institute, Amsterdam
J Immunol 148:3714-22. 1992....
- Restoration of early thymocyte differentiation in T-cell receptor beta-chain-deficient mutant mice by transmembrane signaling through CD3 epsilonC N Levelt
Max Planck Institut fur Immunbiologie, Freiburg, Germany
Proc Natl Acad Sci U S A 90:11401-5. 1993..The data are consistent with the notion that in wild-type mice the DP stage is induced by transmembrane signaling through an immature CD3-TCR beta-chain complex, which can be bypassed by crosslinking of CD3 epsilon alone...
- Stringent V beta requirement for the development of NK1.1+ T cell receptor-alpha/beta+ cells in mouse liverT Ohteki
Ludwig Institute for Cancer Research, University of Lausanne, Switzerland
J Exp Med 183:1277-82. 1996..Collectively, our data indicate that liver NK1+T cells have a stringent requirement for expression of TCR-Vbeta8.2, Vbeta7, or Vbeta2 for their development...
- Oncogenic potential of a pre-T cell receptor lacking the TCR beta variable domainH Jacobs
Division of Molecular Genetics, The Netherlands Cancer Institute, Amsterdam
Oncogene 12:2089-99. 1996In transgenic mice expressing a mutated T cell receptor (TCR) beta chain lacking the variable domain (DeltaV-TCRbeta) T cell differentiation is arrested at the CD4+ CD8+ thymocyte stage...
- A tumor-suppressor function for Fas (CD95) revealed in T cell-deficient miceS L Peng
Section of Rheumatology, Yale University School of Medicine, New Haven, Connecticut, USA
J Exp Med 184:1149-54. 1996..These data indicate that Fas functions as a tumor suppressor, and identifies roles for both alpha beta T cells and gamma delta T cells in Fas-independent tumor regulation...
- T cell receptor beta chain lacking the large solvent-exposed Cbeta FG loop supports normal alpha/beta T cell development and function in transgenic miceS Degermann
Basel Institute for Immunology, CH 4005 Basel, Switzerland
J Exp Med 189:1679-84. 1999..However, functional analysis does not support the above notion, since transgene coding for TCR beta chain lacking the complete FG loop supports normal alpha/beta T cell development and function...
- Absolute requirement for the pre-T cell receptor alpha chain during NK1.1+ TCRalphabeta cell developmentG Eberl
Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne, Epalinges, Switzerland
Eur J Immunol 29:1966-71. 1999..Distinct developmental requirements for pre-TCR expression in the NKT and T cell lineages may reflect differences in the ability of the TCRalphabeta to substitute functionally for the pre-TCR in immature precursor cells...
- Impaired NK1.1 T cell development in mice transgenic for a T cell receptor beta chain lacking the large, solvent-exposed cbeta FG loopS Degermann
Basel Institute for Immunology, CH 4005 Basel, Switzerland
J Exp Med 190:1357-62. 1999..Development of NK1.1 T cells appears to need a TCR-beta conformation dependent on the presence of the Cbeta loop that is not necessarily required for assembly and function of TCRs on most alpha/beta T cells...
- TCRbeta transmembrane tyrosines are required for pre-TCR functionLisa M Spain
Jerome H Holland Laboratory for Biomedical Research, American Red Cross, 15601 Crabbs Branch Way, Rockville, MD 20855, USA
J Immunol 168:127-33. 2002The pre-TCR promotes thymocyte development in the alphabeta lineage. Productive rearrangement of the TCRbeta locus triggers the assembly of the pre-TCR, which includes the pTalpha chain and CD3 epsilongammadeltazeta subunits...
- Chromosomal localization of three vacuolar-H+ -ATPase 16 kDa subunit (ATP6V0C) genes in the murine genomeA M Simckes
Division of Pediatric Nephrology, The Children s Mercy Hospital, UMKC School of Medicine, Kansas City, MO 64108, USA
Cytogenet Genome Res 97:111-5. 2002..Atp6v0c maps to Chromosome 17, closely linked to the Tsc2 locus and D17Mit55. This region of Chromosome 17 in mouse is homologous with chromosome 16 in human where the ATP6V0C gene is localized...
- Allele-specific regulation of TCR beta variable gene segment chromatin structureAnnette M Jackson
Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
J Immunol 175:5186-91. 2005Allelic exclusion of the murine Tcrb locus is imposed at the level of recombination and restricts each cell to produce one functional VDJbeta rearrangement...
- Restriction of endogenous T cell antigen receptor beta rearrangements to Vbeta14 through selective recombination signal sequence modificationsCherry Wu
Howard Hughes Medical Institute, Children s Hospital, CBR Institute for Biomedical Research, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 104:4002-7. 2007..we generated mice whose lymphocytes contained replacement of the Vbeta1412-RS with the 3'Dbeta112-RS on a TCRbeta allele lacking Dbeta segments (the Jbeta1(M6) allele)...
- CTLA-4 on alloreactive CD4 T cells interacts with recipient CD80/86 to promote toleranceJosef Kurtz
Bone Marrow Transplantation Section, Transplantation Biology Research Center, Massachusetts General Hospital Harvard Medical School, Boston, MA 02129, USA
Blood 113:3475-84. 2009..This tolerance is independent of regulatory T cells and culminates in the deletion of directly alloreactive CD4 T cells...
- Surface expression of the beta T cell receptor (TCR) chain in the absence of other TCR or CD3 proteins on immature T cellsH Kishi
Basel Institute for Immunology, Switzerland
EMBO J 10:93-100. 1991..The introduction of the beta TCR gene into scid mice resulted in the expression of the beta TCR on the cell surface of thymocytes and induced the expression of CD4 and CD8 co-receptors as well as transcription of the alpha TCR locus...
- Junctional region sequences of T-cell receptor beta-chain genes expressed by pathogenic anti-DNA autoantibody-inducing helper T cells from lupus mice: possible selection by cationic autoantigensS Adams
Department of Medicine, New England Medical Center, Boston, MA 02111
Proc Natl Acad Sci U S A 88:11271-5. 1991..These results offer a clue regarding the nature of the primary autoantigen that may drive the pathogenic autoimmune response in lupus...
- Segregation patterns of endogenous mouse mammary tumor viruses in five recombinant inbred strain setsB K Lee
Jackson Laboratory, Bar Harbor, Maine 04609
J Virol 64:4568-72. 1990..Mtv-30 was genetically mapped to chromosome 12. Additionally, two previously identified Mtv loci, Mtv-14 and Mtv-23, were genetically mapped to chromosome 4 and chromosome 6, respectively...
- Polymorphism of T-cell receptor genes among laboratory and wild mice: diverse origins of laboratory miceH Nobuhara
Department of Maternal and Child Health, Faculty of Medicine, University of Tokyo, Japan
Immunogenetics 30:405-13. 1989..Analysis of the polymorphisms in these loci suggests that laboratory mice have inherited their genes not only from Mus musculus domesticus, but also from other subspecies, and much more than previously believed from Asian subspecies...
- Identification of two murine loci homologous to the v-cbl oncogeneD C Regnier
Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892
J Virol 63:3678-82. 1989..Analyses of Mus domesticus/M. spretus interspecific backcross mice showed that Cbl-1 maps between the immunoglobulin kappa light chain and T-cell receptor beta chain loci and that Cbl-2 is tightly linked to Thy-1...
- Structure, organization and polymorphism of murine and human T-cell receptor alpha and beta chain gene familiesR K Wilson
Division of Biology, California Institute of Technology, Pasadena 91125
Immunol Rev 101:149-72. 1988
- Isolation of cDNA clones encoding T cell-specific membrane-associated proteinsS M Hedrick
Nature 308:149-53. 1984..These characteristics suggest that it encodes one chain of the elusive antigen receptor on the surface of T lymphocytes...
- T cell receptor beta chain gene rearrangement and selection during thymocyte development in adult miceE C Dudley
Department of Biology, Yale University, New Haven, Connecticut 06511
Immunity 1:83-93. 1994....
- Immune responsiveness in mutant mice lacking T-cell receptor alpha beta+ cellsP Chandler
MRC Clinical Sciences Centre, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK
Immunology 85:531-7. 1995....
- Localization of the thyrotropin-releasing hormone gene, Trh, on mouse chromosome 6M L Roller
Department of Human Genetics, University of Michigan Medical School, Ann Arbor 48109 0618, USA
Mamm Genome 6:443-4. 1995
- Control of thymus-independent intestinal intraepithelial lymphocytes by beta 2-microglobulinO Neuhaus
Department of Immunology, University of Ulm, Germany
Eur J Immunol 25:2332-9. 1995..Regulation of self-reactive thymus-independent i-IEL through beta 2m/ MHC class I may contribute to control of autoreactive immune responses in the intestine...
- Interleukin-7: a cofactor for V(D)J rearrangement of the T cell receptor beta geneK Muegge
Biological Carcinogenesis and Development Program, Program Resources Inc DynCorp, National Cancer Institute Frederick Cancer Research and Development Center, MD 21702
Science 261:93-5. 1993..These data implicate IL-7, a cytokine that is abundantly expressed in embryonic thymus, in driving gene rearrangement during early T cell development...
- Genetic mapping of two mouse homeobox genes Tlx-1 and Tlx-2 to murine chromosomes 19 and 6X Y Wen
Division of Molecular and Developmental Biology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
Genomics 24:388-90. 1994..The proposed gene orders and genetic distances for Tlx-1 and Tlx-2 are centromere 19-Lpc-1-(25.53 cM)-Pltr-4-(5.32 cM)-Tlx-1- (3.19 cM)-Ins-1-(7.45 cM)-Xmv-18, and centromere 6-Tcrb-(12.90 cM)-Mltr-3-(10.75 cM)-Tlx-2-(18.42 cM)-Xmv-6.
- Genetic mapping in human and mouse of the locus encoding TRBP, a protein that binds the TAR region of the human immunodeficiency virus (HIV-1)C A Kozak
Laboratory of Molecular Microbiology, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Genomics 25:66-72. 1995..Western blotting indicates that despite high sequence conservation in human and mouse, the TARBP2 protein differs in apparent size in primate and rodent cells...
- Development of CD4+CD8+ thymocytes in RAG-deficient mice through a T cell receptor beta chain-independent pathwayC J Guidos
Division of Immunology and Cancer, Hospital for Sick Children Research Institute, Toronto, Canada
J Exp Med 181:1187-95. 1995..These results suggest an in vivo pathway for DP thymocyte development which is TCR beta chain independent...
- Differential expression of activation markers during tolerance induction by superantigens in T-cell receptor (beta-chain) transgenic miceD L Perkins
Laboratory of Immunogenetics and Transplantation, Brigham and Women s Hospital, Boston, Massachusetts 02115
Cell Immunol 156:310-21. 1994..However, tolerance induction in our system differs from immunity in terms of the early loss of IL-2R alpha expression, the persistent increased expression of Ly-6A/E, and the lack of development of CD45RBlo memory-type T cells...
- GHRH receptor of little mice contains a missense mutation in the extracellular domain that disrupts receptor functionP Godfrey
Department of Biochemistry, Northwestern University, Evanston, Illinois 60208
Nat Genet 4:227-32. 1993..Similar alterations in GHRHR might explain some isolated GH deficiencies in humans...
- Salmonella typhimurium aroA- infection in gene-targeted immunodeficient mice: major role of CD4+ TCR-alpha beta cells and IFN-gamma in bacterial clearance independent of intracellular locationJ Hess
Department of Immunology, University of Ulm, Germany
J Immunol 156:3321-6. 1996..typhimurium SL7207 Hlys and control strains did not differ in beta 2m-/- mutants. This finding argues against direct correlation of cytosolic location of S. typhimurium SL7207 Hlys with CD8+ T cell dependency of protection...
- T cell receptor-gamma, delta-expressing fetal mouse thymocytes are generated without T cell receptor V beta selectionE Mertsching
U 184 INSERM, Faculte de Medecine, Strasbourg, France
Eur J Immunol 26:804-10. 1996..Taken together, these phenotypic and molecular analyses suggest that fetal TCR gamma delta cells have not been subject to TCR beta selection...
- Short-term dexamethasone treatment modulates the expression of the murine TCR zeta gene locusS Ronchetti
Department of Clinical Medicine, Pathology and Pharmacology DMCPF, Perugia University Medical School, Italy
Cell Immunol 178:124-31. 1997..This newly described effect of DEX may constitute an additional molecular mechanism that contributes to its immunomodulating activity...
- The developmental fate of T cells is critically influenced by TCRgammadelta expressionJ Kang
Department of Molecular and Cell Biology and Cancer Research Laboratory, University of California at Berkeley, 94720, USA
Immunity 8:427-38. 1998..T cells from a common precursor cell depends on productive rearrangement and expression of TCRgammadelta or TCRbeta genes, but whether it is an instructive or a stochastic mechanism that is responsible for this process is unclear...
- Chromosomal localization of the human and murine orthologues of the Drosophila smoothened geneA Chidambaram
Intramural Research Support Program, SAIC Frederick, Frederick, Maryland, 21702, USA
Genomics 53:416-7. 1998
- Defending Against Systemic MycosesGEORGE DEEPE; Fiscal Year: 2008..The collaborative and synergistic effort manifested by this group of investigators will provide new and exciting information regarding prevention and/or treatment of these problematic fungi. ..
- PROTECTIVE ANTIGENS FROM HISTOPLASMA CAPSULATUMGEORGE DEEPE; Fiscal Year: 2007..abstract_text> ..
- The Basis of Functional Variation in Gamma/Delta T cellsREBECCA O BRIEN; Fiscal Year: 2009..We will also examine the importance to disease outcome of the ability of each subset to produce particular cytokines, induce the death of other cells, and undergo apoptosis. ..
- Spontaneous Corneal Inflammation in gd T cell absenceREBECCA O BRIEN; Fiscal Year: 2005..In addition, we will carryout experiments designed to examine whether the disease is autoimmune, results from bacterial infection, or stems from damage caused by a chemical released from dirty cage litter. ..
- Identifying Ligands with Soluble Gamma/Delta TCRsREBECCA O BRIEN; Fiscal Year: 2006..3 sTCR. The backup approach involves generation of ligand specific mAbs, identified by their ability to block sTCR/ligand binding, as reagents to affinity-purify the ligand. ..
- Factors that modulate thymic outputThomas Serwold; Fiscal Year: 2006..In addition, it will be directly relevant to therapies that would involve skewing of T cell development to favor T cells with desired specificities. ..
- Immunobiology of NKT cell development and functionDEREK B SANT apos ANGELO; Fiscal Year: 2010..Understanding key aspects of iNKT cell development will eventually make it possible to alter the function of these cells using gene therapy approaches in an effort to control cancer and other diseases. ..
- B1B lymphocytes generate T cell-independent memoryKISHORE ALUGUPALLI; Fiscal Year: 2009..Understanding the basis for the longevity of the Tl protective responses conferred by B1b cells will provide novel approaches to generate effective vaccines against pathogens expressing Tl antigens. ..
- 5th Comparative Medicine Resource Center Director Mtg.Stephen Barthold; Fiscal Year: 2008....
- Role of Galectin-4 in ColitisAtsushi Mizoguchi; Fiscal Year: 2008..These studies will not only enhance understanding of the pathogenic mechanisms of IBD but also provide important information to develop new therapeutic approaches for human IBD. ..
- Mechanisms of CTLA-4 FunctionJoonsoo Kang; Fiscal Year: 2007..Understanding these processes is critical for designing novel therapeutic approaches for vaccine development, autoimmune disease, and in transplant and tumor immunology. ..
- 3RD ANNUAL MUTANT MOUSE REGIONAL RESOURCE CENTER MEETINGStephen Barthold; Fiscal Year: 2003....
- Determination of Mechanism of T cell Lineage CommittmentJoonsoo Kang; Fiscal Year: 2006..The long-term objective of this application is to identify genes that determine T cell lineage fate. ..
- HELICOBACTER DIAGNOSTIC ASSAYS FOR LABORATORY MICEStephen Barthold; Fiscal Year: 2004..abstract_text> ..
- Role of Chemokines in Anthrax PathogenesisWendy Peters; Fiscal Year: 2004....
- IMMUNOBIOLOGY OF POSITIVE SELECTION ON SELF PEPTIDESDEREK SANT ANGELO; Fiscal Year: 2003..This work will give us insights into phenomenon such as immunodominance and the link between certain MHC alleles and autoimmunity. ..
- Inflammatory Bowel Disease in TCR-Mutant MiceAtul Bhan; Fiscal Year: 2006..unreadable] [unreadable] [unreadable] [unreadable] ..
- The function of membrane vesiculation in CTLA-4-mediate*Joonsoo Kang; Fiscal Year: 2005..To date there has been limited advancement on the ability to increase CTLA-4 function. The proposed model of CTLA-4 function would provide a novel means to increase CTLA-4-mediated inhibition in vivo. ..
- Chemokines and their Receptors in Anthrax InfectionWendy Peters; Fiscal Year: 2004..This information may provide a rationale for the use of chemokine/chemokine receptor antagonists in the treatment of anthrax. ..
- Regulation of T cell development by SOX13Joonsoo Kang; Fiscal Year: 2009..Collectively, the genetic program controlling T cell lineage commitment and maturation will be determined, allowing a better understanding of leukemogenesis. ..