Tcrb

Summary

Gene Symbol: Tcrb
Description: T cell receptor beta chain
Alias: TCRbeta, Tib
Species: mouse

Top Publications

  1. ncbi Onset of TCR-beta gene rearrangement and role of TCR-beta expression during CD3-CD4-CD8- thymocyte differentiation
    D I Godfrey
    DNAX Research Institute, Palo Alto, CA 94304
    J Immunol 152:4783-92. 1994
  2. pmc Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15-deficient mice
    M K Kennedy
    Immunex Corporation, Seattle, Washington 98101, USA
    J Exp Med 191:771-80. 2000
  3. pmc Mature follicular dendritic cell networks depend on expression of lymphotoxin beta receptor by radioresistant stromal cells and of lymphotoxin beta and tumor necrosis factor by B cells
    R Endres
    Institute of Medical Microbiology, Immunology and Hygiene, Technical University of Munich, D 81675 Munich, Germany
    J Exp Med 189:159-68. 1999
  4. pmc The CD3gamma chain is essential for development of both the TCRalphabeta and TCRgammadelta lineages
    M C Haks
    Division of Immunology, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Huis, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    EMBO J 17:1871-82. 1998
  5. ncbi CD3 epsilon-mediated signals rescue the development of CD4+CD8+ thymocytes in RAG-2-/- mice in the absence of TCR beta chain expression
    Y Shinkai
    Howard Hughes Medical Institute, Boston, MA
    Int Immunol 6:995-1001. 1994
  6. pmc Id2-, RORgammat-, and LTbetaR-independent initiation of lymphoid organogenesis in ocular immunity
    Takahiro Nagatake
    Division of Mucosal Immunology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Minato ku, Tokyo 108 8639, Japan
    J Exp Med 206:2351-64. 2009
  7. ncbi Functions of TCR and pre-TCR subunits: lessons from gene ablation
    B Malissen
    Centre d Immunologie, INSERM CNRS de Marseille Luminy, France
    Curr Opin Immunol 8:383-93. 1996
  8. ncbi Structure and function of the pre-T cell receptor
    H von Boehmer
    Institut Necker, INSERM 373, Paris, France
    Annu Rev Immunol 15:433-52. 1997
  9. ncbi Alternative and classical NF-kappa B signaling retain autoreactive B cells in the splenic marginal zone and result in lupus-like disease
    Thomas Enzler
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA
    Immunity 25:403-15. 2006
  10. ncbi Foxp3-dependent programme of regulatory T-cell differentiation
    Marc A Gavin
    Department of Immunology, University of Washington, Seattle, Washington 98195, USA
    Nature 445:771-5. 2007

Research Grants

  1. Defending Against Systemic Mycoses
    GEORGE DEEPE; Fiscal Year: 2008
  2. PROTECTIVE ANTIGENS FROM HISTOPLASMA CAPSULATUM
    GEORGE DEEPE; Fiscal Year: 2007
  3. The Basis of Functional Variation in Gamma/Delta T cells
    REBECCA O BRIEN; Fiscal Year: 2009
  4. Spontaneous Corneal Inflammation in gd T cell absence
    REBECCA O BRIEN; Fiscal Year: 2005
  5. Identifying Ligands with Soluble Gamma/Delta TCRs
    REBECCA O BRIEN; Fiscal Year: 2006
  6. Factors that modulate thymic output
    Thomas Serwold; Fiscal Year: 2006
  7. Immunobiology of NKT cell development and function
    DEREK B SANT apos ANGELO; Fiscal Year: 2010
  8. B1B lymphocytes generate T cell-independent memory
    KISHORE ALUGUPALLI; Fiscal Year: 2009
  9. 5th Comparative Medicine Resource Center Director Mtg.
    Stephen Barthold; Fiscal Year: 2008
  10. Role of Galectin-4 in Colitis
    Atsushi Mizoguchi; Fiscal Year: 2008

Scientific Experts

Detail Information

Publications131 found, 100 shown here

  1. ncbi Onset of TCR-beta gene rearrangement and role of TCR-beta expression during CD3-CD4-CD8- thymocyte differentiation
    D I Godfrey
    DNAX Research Institute, Palo Alto, CA 94304
    J Immunol 152:4783-92. 1994
    ....
  2. pmc Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15-deficient mice
    M K Kennedy
    Immunex Corporation, Seattle, Washington 98101, USA
    J Exp Med 191:771-80. 2000
    ..Moreover, the ability to rescue lymphoid defects in IL-15(-/-) mice by IL-15 administration represents a powerful means by which to further elucidate the biological roles of this cytokine...
  3. pmc Mature follicular dendritic cell networks depend on expression of lymphotoxin beta receptor by radioresistant stromal cells and of lymphotoxin beta and tumor necrosis factor by B cells
    R Endres
    Institute of Medical Microbiology, Immunology and Hygiene, Technical University of Munich, D 81675 Munich, Germany
    J Exp Med 189:159-68. 1999
    ..Thus, development of splenic FDC networks depends on expression of LTbeta and TNF by B lymphocytes and LTbetaR by radioresistant stromal cells...
  4. pmc The CD3gamma chain is essential for development of both the TCRalphabeta and TCRgammadelta lineages
    M C Haks
    Division of Immunology, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Huis, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    EMBO J 17:1871-82. 1998
    ..selectively lacking expression of CD3gamma, in which expression of CD3delta, CD3epsilon, CD3zeta, pTalpha and TCRbeta remained undisturbed. Thus, all components for composing a pre-TCR are available, with the exception of CD3gamma...
  5. ncbi CD3 epsilon-mediated signals rescue the development of CD4+CD8+ thymocytes in RAG-2-/- mice in the absence of TCR beta chain expression
    Y Shinkai
    Howard Hughes Medical Institute, Boston, MA
    Int Immunol 6:995-1001. 1994
    ..Together, these data strongly indicate that TCR beta chain-mediated developmental signals are transduced by CD3 components and provide potential insights into mechanisms by which TCR beta chain expression may effect this process...
  6. pmc Id2-, RORgammat-, and LTbetaR-independent initiation of lymphoid organogenesis in ocular immunity
    Takahiro Nagatake
    Division of Mucosal Immunology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Minato ku, Tokyo 108 8639, Japan
    J Exp Med 206:2351-64. 2009
    ..Thus, TALT shares immunological features with MALT but has a distinct tissue genesis mechanism and plays a key role in ocular immunity...
  7. ncbi Functions of TCR and pre-TCR subunits: lessons from gene ablation
    B Malissen
    Centre d Immunologie, INSERM CNRS de Marseille Luminy, France
    Curr Opin Immunol 8:383-93. 1996
    ..By activating intracellular effectors, the CD3 subunits probably modulate gene expression profiles and drive the maturing alpha beta T cells through a precise developmental sequence...
  8. ncbi Structure and function of the pre-T cell receptor
    H von Boehmer
    Institut Necker, INSERM 373, Paris, France
    Annu Rev Immunol 15:433-52. 1997
    ..The function of the pre-TCR cannot be fully assumed by an alpha beta TCR that is expressed abnormally early in T cell development...
  9. ncbi Alternative and classical NF-kappa B signaling retain autoreactive B cells in the splenic marginal zone and result in lupus-like disease
    Thomas Enzler
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA
    Immunity 25:403-15. 2006
    ..Thus, both classical and alternative NF-kappaB signaling are important for development of lupus-like disease associated with BAFF overproduction. The same mechanisms may be involved in the pathogenesis of human SLE...
  10. ncbi Foxp3-dependent programme of regulatory T-cell differentiation
    Marc A Gavin
    Department of Immunology, University of Washington, Seattle, Washington 98195, USA
    Nature 445:771-5. 2007
    ..This adaptation includes Foxp3-dependent repression of cyclic nucleotide phosphodiesterase 3B, affecting genes responsible for Tr cell homeostasis...
  11. ncbi Mutations in T-cell antigen receptor genes alpha and beta block thymocyte development at different stages
    P Mombaerts
    Howard Hughes Medical Institute, Center for Cancer Research, Cambridge, Massachusetts
    Nature 360:225-31. 1992
    ..TCR-alpha is irrelevant in these developmental processes. The development of gamma delta T cells does not depend on either TCR-alpha or TCR-beta...
  12. pmc Creation of a large genomic deletion at the T-cell antigen receptor beta-subunit locus in mouse embryonic stem cells by gene targeting
    P Mombaerts
    Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge 02139
    Proc Natl Acad Sci U S A 88:3084-7. 1991
    ....
  13. ncbi Induction by antigen of intrathymic apoptosis of CD4+CD8+TCRlo thymocytes in vivo
    K M Murphy
    Department of Pathology, Washington University School of Medicine, St Louis, MO 63110
    Science 250:1720-3. 1990
    ..Apoptosis of cortical thymocytes can be seen within 20 hours of treatment. These results provide direct evidence for the in vivo role of apoptosis in the development of antigen-induced tolerance...
  14. ncbi Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen
    H Pircher
    Department of Experimental Pathology, University Hospital, Zurich, Switzerland
    Nature 342:559-61. 1989
    ..Thus the same transgenic TCR-expressing T cells may be tolerized at different stages of their maturation and at different locations in the thymus depending on the antigen involved...
  15. ncbi Incomplete T cell receptor V beta allelic exclusion and dual V beta-expressing cells
    D Balomenos
    Department of Immunology, Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunol 155:3308-12. 1995
    ..These findings may have important implications for TCR selection and specificity, age-related repertoire changes, and autoimmune disease pathogenesis...
  16. ncbi Analysis and expression of a cloned pre-T cell receptor gene
    C Saint-Ruf
    Unité INSERM 373, Institut Necker, Paris, France
    Science 266:1208-12. 1994
    ..Identification of the pT alpha gene represents an essential step in the structure-function analysis of the pre-TCR complex...
  17. ncbi Spontaneous development of inflammatory bowel disease in T cell receptor mutant mice
    P Mombaerts
    Howard Hughes Medical Institute, Department of Biology Massachusetts Institute of Technology Cambridge 02139
    Cell 75:274-82. 1993
    ..IBD in the mutant mice has some of the features of the human disease ulcerative colitis. Based on these results, we suggest that dysfunction of the mucosal immune system may underly the pathogenesis of some types of IBD in humans...
  18. pmc Deletion of the mouse T-cell receptor beta gene enhancer blocks alphabeta T-cell development
    G Bouvier
    Centre d immunologie de Marseille Luminy, Institut National de la Santé et de la Recherche Médicale Centre National de la Recherche Scientifique, France
    Proc Natl Acad Sci U S A 93:7877-81. 1996
    ..These data formally establish the critical role played by Ebeta in cis-activation of the TCR beta locus for V(D)J recombination during alphabeta T-cell development...
  19. ncbi A motif within the T cell receptor alpha chain constant region connecting peptide domain controls antigen responsiveness
    B T Backstrom
    Basel Institute for Immunology, Switzerland
    Immunity 5:437-47. 1996
    ..This conserved alpha chain connecting peptide motif might mediate the transfer of signals from the alphabeta heterodimer to the CD3/zeta complex...
  20. pmc Signaling capacity of the T cell antigen receptor is negatively regulated by the PTP1C tyrosine phosphatase
    G Pani
    Department of Medicine, University of Toronto, Ontario, Canada
    J Exp Med 184:839-52. 1996
    ....
  21. ncbi T cell-mediated elimination of B7.2 transgenic B cells
    S Fournier
    Department of Molecular and Cellular Biology, University of California at Berkeley, 94720, USA
    Immunity 6:327-39. 1997
    ..2 transgenic B cells are not eliminated, but proliferate and differentiate normally. Our findings suggest that, in the absence of high affinity ligand for the TCR, the CD28-B7.2 system participates in the regulation of B cell homeostasis...
  22. ncbi Early alpha beta T cell development in the thymus of normal and genetically altered mice
    H J Fehling
    Basel Institute for Immunology, Switzerland
    Curr Opin Immunol 9:263-75. 1997
    ..Recent studies of pre-TCR function have led to a better understanding of the molecular events in early thymocyte development...
  23. pmc CD3 delta deficiency arrests development of the alpha beta but not the gamma delta T cell lineage
    V P Dave
    Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    EMBO J 16:1360-70. 1997
    ..Absence of CD3 delta specifically blocks the thymic selection processes that mediate the transition from the double-positive to single-positive stages of development...
  24. ncbi Deficient positive selection of CD4 T cells in mice displaying altered repertoires of MHC class II-bound self-peptides
    C E Grubin
    Department of Immunology, University of Washington, Seattle 98195, USA
    Immunity 7:197-208. 1997
    ..In addition, the data suggest that T cell receptor repertoires selected in wild-type mice and in mice displaying limited spectra of self-peptides are distinct...
  25. pmc B lymphocytes induce the formation of follicular dendritic cell clusters in a lymphotoxin alpha-dependent fashion
    Y X Fu
    Department of Laboratory Medicine Pathology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Exp Med 187:1009-18. 1998
    ..Thus, B cells themselves provide an essential signal that induces and maintains the lymphoid microenvironment essential for GC formation and class-switched Ig responses...
  26. ncbi Regulation of Vbeta germline transcription in RAG-deficient mice by the CD3epsilon-mediated signals: implication of Vbeta transcriptional regulation in TCR beta allelic exclusion
    M Senoo
    Department of Molecular Oncology, Nippon Roche Research Center, Kamakura City, Kanagawa, Japan
    Int Immunol 10:553-60. 1998
    ..These data indicate that the regulation of Vbeta germline transcription by the signals through the pre-TCR complex may reflect the modulation of Vbeta accessibility to the VDJ recombinase, which contributes to TCR beta allelic exclusion...
  27. ncbi A mouse carrying genetic defect in the choice between T and B lymphocytes
    Y Tokoro
    Department of Immunology, University of Tsukuba, Tennodai, Japan
    J Immunol 161:4591-8. 1998
    ..Thus, tg epsilon26 mice provide a novel mouse model in that lineage choice between T and B lymphocytes is genetically defective...
  28. pmc CD5 expression is developmentally regulated by T cell receptor (TCR) signals and TCR avidity
    H S Azzam
    Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Exp Med 188:2301-11. 1998
    ..Taken together, these observations suggest that the developmental regulation of CD5 in response to TCR signaling and TCR avidity represents a mechanism for fine tuning of the TCR signaling response...
  29. pmc Lymphotoxin alpha/beta and tumor necrosis factor are required for stromal cell expression of homing chemokines in B and T cell areas of the spleen
    V N Ngo
    Department of Microbiology and Immunology, University of California San Francisco, San Francisco, California 94143, USA
    J Exp Med 189:403-12. 1999
    ..Together these findings indicate that LTalpha1beta2 and TNF are required for the development and function of B and T zone stromal cells that make chemokines necessary for lymphocyte compartmentalization in the spleen...
  30. ncbi Organogenic role of B lymphocytes in mucosal immunity
    T V Golovkina
    Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
    Science 286:1965-8. 1999
    ..The lack of M cells abrogated infection with a milk-borne retrovirus. Thus, in addition to secretion of antibodies and presentation of antigens, B cells are important for organogenesis of the mucosal immune barriers...
  31. ncbi Recombination signal sequences restrict chromosomal V(D)J recombination beyond the 12/23 rule
    C H Bassing
    Howard Hughes Medical Institute, Children s Hospital and Department of Genetics, Harvard Medical School and The Center for Blood Research, Boston, Massachusetts 02115, USA
    Nature 405:583-6. 2000
    ..This targeting is precise and position-independent. This additional restriction on V(D)J recombination has important implications for the regulation of variable region gene assembly and repertoire development...
  32. ncbi A primitive T cell-independent mechanism of intestinal mucosal IgA responses to commensal bacteria
    A J MacPherson
    Institute of Experimental Immunology, Universitatsspital, Schmelzbergstrasse 12, CH8091, Zurich, Switzerland
    Science 288:2222-6. 2000
    ....
  33. ncbi Development of dendritic epidermal T cells with a skewed diversity of gamma delta TCRs in V delta 1-deficient mice
    H Hara
    Department of Immunology, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
    J Immunol 165:3695-705. 2000
    ....
  34. ncbi Innate immunity to viruses: control of vaccinia virus infection by gamma delta T cells
    L K Selin
    Department of Pathology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    J Immunol 166:6784-94. 2001
    ..Thus, gammadelta T cells can be mediators of innate immunity to viruses, having a significant impact on virus replication early in infection in the presence or absence of the adaptive immune response...
  35. ncbi Autoreactive diabetogenic T-cells in NOD mice can efficiently expand from a greatly reduced precursor pool
    D V Serreze
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Diabetes 50:1992-2000. 2001
    ..This might allow diabetogenic T-cells in NOD mice to undergo an efficient expansion before encountering antigen, which would represent an important and previously unconsidered aspect of pathogenesis...
  36. ncbi Comparative genomics of the human and mouse T cell receptor loci
    G Glusman
    The Institute for Systems Biology, 4225 Roosevelt Way NE, Seattle, WA 98105, USA
    Immunity 15:337-49. 2001
    ..The genomic landscape of the TCR loci provides fundamental insights into TCR evolution as highly localized and tightly regulated gene families...
  37. pmc Resident skin-specific gammadelta T cells provide local, nonredundant regulation of cutaneous inflammation
    Michael Girardi
    Department of Dermatology and the Yale Skin Diseases Research Core Center, Yale University, New Haven, CT 06520, USA
    J Exp Med 195:855-67. 2002
    ....
  38. pmc Conserved T cell receptor usage in primary and recall responses to an immunodominant influenza virus nucleoprotein epitope
    Katherine Kedzierska
    Department of Microbiology and Immunology, University of Melbourne, Parkville 3010, Australia
    Proc Natl Acad Sci U S A 101:4942-7. 2004
    ..Based on the length and amino acid sequences of the complementarity-determining region 3 of TCRbeta (CDR3beta) loop and associated Jbeta usage, the same dominant TCRbeta signatures were found in the blood, the ..
  39. ncbi Obligatory role for cooperative signaling by pre-TCR and Notch during thymocyte differentiation
    Maria Ciofani
    Department of Immunology, University of Toronto, Sunnybrook and Women s College Health Sciences Centre, Toronto, Ontario, Canada
    J Immunol 172:5230-9. 2004
    ..Collectively, our results demonstrate an essential role for Notch receptor-ligand interactions in enabling the autonomous signaling capacity of the pre-TCR complex...
  40. ncbi Regulatory T cell lineage specification by the forkhead transcription factor foxp3
    Jason D Fontenot
    Department of Immunology, University of Washington, Seattle, Washington 98195, USA
    Immunity 22:329-41. 2005
    ..Analysis of Foxp3 expression during thymic development suggests that this mechanism is not hard-wired but is dependent on TCR/MHC ligand interactions...
  41. pmc Spontaneous atopic dermatitis in mice expressing an inducible thymic stromal lymphopoietin transgene specifically in the skin
    Jane Yoo
    Department of Immunology, University of Washington School of Medicine, Seattle, WA 98101, USA
    J Exp Med 202:541-9. 2005
    ..These transgenic mice demonstrate that TSLP can initiate a cascade of allergic inflammation in the skin and provide a valuable animal model for future study of this common disease...
  42. pmc Regulated costimulation in the thymus is critical for T cell development: dysregulated CD28 costimulation can bypass the pre-TCR checkpoint
    Joy A Williams
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 175:4199-207. 2005
    ..levels extremely low on immature thymocytes but increasing dramatically as CD4- CD8- cells initiate expression of TCRbeta. B7-1 and B7-2, the ligands for CD28, have a restricted distribution in the thymic cortex where immature ..
  43. ncbi Perisinusoidal B cells in the bone marrow participate in T-independent responses to blood-borne microbes
    Annaiah Cariappa
    Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02129, USA
    Immunity 23:397-407. 2005
    ..The bone marrow represents a unique type of secondary lymphoid organ in which mature B cells are strategically positioned in the path of circulating microbes...
  44. ncbi Cell surface recycling of internalized antigen permits dendritic cell priming of B cells
    Amy Bergtold
    Integrated Program in Cellular, Molecular, and Biophysical Studies, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Immunity 23:503-14. 2005
    ..Thus dendritic cells are equipped with both non-degradative and degradative antigen uptake pathways to facilitate antigen presentation to both B and T cells...
  45. ncbi Expression of rearranged TCRgamma genes in natural killer cells suggests a minor thymus-dependent pathway of lineage commitment
    Linnea Lora Veinotte
    Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, British Columbia, Canada, V5Z 1L3
    Blood 107:2673-9. 2006
    ..5% of neonatal and 1% of adult mouse splenic NK cells, and similar levels are detected in NK cells from TCRbeta,delta double-knockout mice, excluding the possibility of T-cell contamination...
  46. pmc Stoichiometry of the murine gammadelta T cell receptor
    Sandra M Hayes
    Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 203:47-52. 2006
    ..Our results support a model of murine gammadeltaTCR stoichiometry in which there are two CD3gammaepsilon dimers for every TCRgammadelta heterodimer...
  47. ncbi Cutting edge: enhancement of antibody responses through direct stimulation of B and T cells by type I IFN
    Agnes Le Bon
    The Edward Jenner Institute for Vaccine Research, Compton, Newbury, Berkshire, UK
    J Immunol 176:2074-8. 2006
    ..These results indicate that IFN-alphabetaR signaling in both B and T cells plays an important role in the stimulation of Ab responses by IFN-alphabeta...
  48. ncbi Local increase in thymic stromal lymphopoietin induces systemic alterations in B cell development
    Alexander Astrakhan
    Department of Immunology, University of Washington School of Medicine Seattle, Washington 98195, USA
    Nat Immunol 8:522-31. 2007
    ..These observations suggest that signals mediating localized TSLP expression may modulate systemic B cell development and promote humoral autoimmunity...
  49. ncbi Role of CXCR5 and CCR7 in follicular Th cell positioning and appearance of a programmed cell death gene-1high germinal center-associated subpopulation
    Nicole M Haynes
    Howard Hughes Medical Institute, University of California, San Francisco, CA 94143, USA
    J Immunol 179:5099-108. 2007
    ....
  50. ncbi Protein kinase C theta plays a fundamental role in different types of chronic colitis
    Kiyotaka Nagahama
    Department of Pathology, Experimental Pathology, Massachusetts General Hospital, Boston, Massachusetts, USA
    Gastroenterology 134:459-69. 2008
    ..A key molecule associated with the IS is protein kinase C (PKC) theta. However, the role of PKCtheta in the pathogenesis of colitis has not fully been defined...
  51. doi Requirement for lymphoid tissue-inducer cells in isolated follicle formation and T cell-independent immunoglobulin A generation in the gut
    Masayuki Tsuji
    Laboratory for Mucosal Immunity, Research Center for Allergy and Immunology, RIKEN Yokohama 1 7 22, Tsurumi, Yokohama, 230 0045, Japan
    Immunity 29:261-71. 2008
    ..These findings provide insight into the crosstalk between bacteria, ROR gamma t(+)LTi cells, SCs, DCs, and B cells required for ILF formation and establish a critical role of ILFs in T cell-independent IgA synthesis in gut...
  52. pmc Functional overlap in the cis-acting regulation of the V(D)J recombination at the TCRbeta locus
    Bernard Khor
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Mol Immunol 46:321-6. 2009
    ..In the TCRbeta locus, accessibility of the Dbeta1-Jbeta1 gene segment cluster relies on the function of an enhancer, Ebeta, and ..
  53. pmc Th17-polarized immune response in a murine model of hypersensitivity pneumonitis and lung fibrosis
    Philip L Simonian
    Department of Medicine, University of Colorado Denver, Denver, CO 80262, USA
    J Immunol 182:657-65. 2009
    ..In the absence of alphabeta T cells, TCRbeta(-/-) mice exposed to S...
  54. pmc The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation
    Meghan A Koch
    Benaroya Research Institute, Seattle, Washington, USA
    Nat Immunol 10:595-602. 2009
    ....
  55. doi T cells dampen innate immune responses through inhibition of NLRP1 and NLRP3 inflammasomes
    Greta Guarda
    Department of Biochemistry, University of Lausanne, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Nature 460:269-73. 2009
    ....
  56. pmc The requirement for pre-TCR during thymic differentiation enforces a developmental pause that is essential for V-DJβ rearrangement
    Karen S Hathcock
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 6:e20639. 2011
    ..However, the requirement for pre-TCR signals and the exclusion of alternative stimuli such as CD28 enforce a developmental "pause" in early DN3 cells that is essential for productive TCRβ rearrangement to occur...
  57. pmc Follicular regulatory T cells expressing Foxp3 and Bcl-6 suppress germinal center reactions
    Yeonseok Chung
    Department of Immunology, Center for Cancer Immunology Research, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    Nat Med 17:983-8. 2011
    ..These results unveil a Bcl-6-CXCR5 axis in T(reg) cells that drives the development of follicular regulatory T (T(FR)) cells that function to inhibit the germinal center reactions...
  58. pmc Pathogen-specific Treg cells expand early during mycobacterium tuberculosis infection but are later eliminated in response to Interleukin-12
    Shahin Shafiani
    Seattle Biomedical Research Institute, Seattle, WA 98109, USA
    Immunity 38:1261-70. 2013
    ..These findings have important implications for the prevention and treatment of tuberculosis and other chronic diseases in which antigen-specific Treg cells restrict immunity...
  59. ncbi Mouse T-cell receptor variable gene segment families
    B Arden
    Paul Ehrlich Institute, Langen, Germany
    Immunogenetics 42:501-30. 1995
    ..In the mouse, most V gene segments can be grouped into subfamilies of closely related genes with significantly less similarity between different subfamilies...
  60. ncbi The induction of a protective response in Leishmania major-infected BALB/c mice with anti-CD40 mAb
    W G Ferlin
    Department of Immunobiology, DNAX Research Institute, Palo Alto, CA, USA
    Eur J Immunol 28:525-31. 1998
    ..major infection and raises the possibility of utilizing this approach for vaccination strategies...
  61. ncbi Negative regulation of airway responsiveness that is dependent on gammadelta T cells and independent of alphabeta T cells
    M Lahn
    Division of Basic Immunology, Department of Medicine, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, Colorado 80206, USA
    Nat Med 5:1150-6. 1999
    ..This function of gammadelta T cells differs from previously described immune-dependent mechanisms and may reflect their interaction with innate systems of host defense...
  62. ncbi T cell development in TCR beta enhancer-deleted mice: implications for alpha beta T cell lineage commitment and differentiation
    I Leduc
    Centre d immunologie de Marseille Luminy, Institut National de la Santé et de la Recherche Médicale Centre National de la Recherche Scientifique, Marseille, France
    J Immunol 165:1364-73. 2000
    ..We discuss these data with respect to the functional role of E beta in driving alpha beta T cell differentiation and the mechanism of alpha beta T lineage commitment...
  63. ncbi Cutting edge: germinal centers can be induced in the absence of T cells
    V M Lentz
    Kimmel Cancer Center and Department of Microbiology and Immunology, Jefferson Medical College, Philadelphia, PA 19107, USA
    J Immunol 167:15-20. 2001
    ..Therefore, T cells may be required for B cell differentiation processes associated with the intermediate and latter stages of the GC reaction, but they are dispensable for the induction and initial development of this response...
  64. ncbi Peripheral lymphoid development and function in TCR mutant mice
    P Mombaerts
    Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge 02139
    Int Immunol 6:1061-70. 1994
    ..Natural killer cell function is not impaired in any of the mutant mice. TCR mutant mice will prove useful in dissecting differential functions of alpha beta and gamma delta T cells in vivo...
  65. ncbi 'Coreceptor tuning': cytokine signals transcriptionally tailor CD8 coreceptor expression to the self-specificity of the TCR
    Jung Hyun Park
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Immunol 8:1049-59. 2007
    ..This dynamic interplay induces individual CD8+ T cells to express CD8 in quantities appropriate for the self-specificity of their TCR, promoting the engagement of self ligands, yet avoiding autoreactivity...
  66. pmc Different composition of the human and the mouse gammadelta T cell receptor explains different phenotypes of CD3gamma and CD3delta immunodeficiencies
    Gabrielle M Siegers
    Max Planck Institute of Immunobiology and University of Freiburg, 79108 Freiburg, Germany
    J Exp Med 204:2537-44. 2007
    ..Collectively, our results indicate that the different gammadelta T cell phenotypes between CD3gamma-deficient humans and mice can be explained by differences in their gammadelta TCR composition...
  67. ncbi T cell receptor-alpha beta lacking the beta-chain V domain can be expressed at the cell surface but prohibits T cell maturation
    F Ossendorp
    Division of Immunology, The Netherlands Cancer Institute, Amsterdam
    J Immunol 148:3714-22. 1992
    ....
  68. pmc Restoration of early thymocyte differentiation in T-cell receptor beta-chain-deficient mutant mice by transmembrane signaling through CD3 epsilon
    C N Levelt
    Max Planck Institut fur Immunbiologie, Freiburg, Germany
    Proc Natl Acad Sci U S A 90:11401-5. 1993
    ..The data are consistent with the notion that in wild-type mice the DP stage is induced by transmembrane signaling through an immature CD3-TCR beta-chain complex, which can be bypassed by crosslinking of CD3 epsilon alone...
  69. pmc Stringent V beta requirement for the development of NK1.1+ T cell receptor-alpha/beta+ cells in mouse liver
    T Ohteki
    Ludwig Institute for Cancer Research, University of Lausanne, Switzerland
    J Exp Med 183:1277-82. 1996
    ..Collectively, our data indicate that liver NK1+T cells have a stringent requirement for expression of TCR-Vbeta8.2, Vbeta7, or Vbeta2 for their development...
  70. ncbi Oncogenic potential of a pre-T cell receptor lacking the TCR beta variable domain
    H Jacobs
    Division of Molecular Genetics, The Netherlands Cancer Institute, Amsterdam
    Oncogene 12:2089-99. 1996
    In transgenic mice expressing a mutated T cell receptor (TCR) beta chain lacking the variable domain (DeltaV-TCRbeta) T cell differentiation is arrested at the CD4+ CD8+ thymocyte stage...
  71. pmc A tumor-suppressor function for Fas (CD95) revealed in T cell-deficient mice
    S L Peng
    Section of Rheumatology, Yale University School of Medicine, New Haven, Connecticut, USA
    J Exp Med 184:1149-54. 1996
    ..These data indicate that Fas functions as a tumor suppressor, and identifies roles for both alpha beta T cells and gamma delta T cells in Fas-independent tumor regulation...
  72. pmc T cell receptor beta chain lacking the large solvent-exposed Cbeta FG loop supports normal alpha/beta T cell development and function in transgenic mice
    S Degermann
    Basel Institute for Immunology, CH 4005 Basel, Switzerland
    J Exp Med 189:1679-84. 1999
    ..However, functional analysis does not support the above notion, since transgene coding for TCR beta chain lacking the complete FG loop supports normal alpha/beta T cell development and function...
  73. ncbi Absolute requirement for the pre-T cell receptor alpha chain during NK1.1+ TCRalphabeta cell development
    G Eberl
    Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne, Epalinges, Switzerland
    Eur J Immunol 29:1966-71. 1999
    ..Distinct developmental requirements for pre-TCR expression in the NKT and T cell lineages may reflect differences in the ability of the TCRalphabeta to substitute functionally for the pre-TCR in immature precursor cells...
  74. pmc Impaired NK1.1 T cell development in mice transgenic for a T cell receptor beta chain lacking the large, solvent-exposed cbeta FG loop
    S Degermann
    Basel Institute for Immunology, CH 4005 Basel, Switzerland
    J Exp Med 190:1357-62. 1999
    ..Development of NK1.1 T cells appears to need a TCR-beta conformation dependent on the presence of the Cbeta loop that is not necessarily required for assembly and function of TCRs on most alpha/beta T cells...
  75. ncbi TCRbeta transmembrane tyrosines are required for pre-TCR function
    Lisa M Spain
    Jerome H Holland Laboratory for Biomedical Research, American Red Cross, 15601 Crabbs Branch Way, Rockville, MD 20855, USA
    J Immunol 168:127-33. 2002
    The pre-TCR promotes thymocyte development in the alphabeta lineage. Productive rearrangement of the TCRbeta locus triggers the assembly of the pre-TCR, which includes the pTalpha chain and CD3 epsilongammadeltazeta subunits...
  76. ncbi Chromosomal localization of three vacuolar-H+ -ATPase 16 kDa subunit (ATP6V0C) genes in the murine genome
    A M Simckes
    Division of Pediatric Nephrology, The Children s Mercy Hospital, UMKC School of Medicine, Kansas City, MO 64108, USA
    Cytogenet Genome Res 97:111-5. 2002
    ..Atp6v0c maps to Chromosome 17, closely linked to the Tsc2 locus and D17Mit55. This region of Chromosome 17 in mouse is homologous with chromosome 16 in human where the ATP6V0C gene is localized...
  77. ncbi Allele-specific regulation of TCR beta variable gene segment chromatin structure
    Annette M Jackson
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 175:5186-91. 2005
    Allelic exclusion of the murine Tcrb locus is imposed at the level of recombination and restricts each cell to produce one functional VDJbeta rearrangement...
  78. pmc Restriction of endogenous T cell antigen receptor beta rearrangements to Vbeta14 through selective recombination signal sequence modifications
    Cherry Wu
    Howard Hughes Medical Institute, Children s Hospital, CBR Institute for Biomedical Research, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 104:4002-7. 2007
    ..we generated mice whose lymphocytes contained replacement of the Vbeta1412-RS with the 3'Dbeta112-RS on a TCRbeta allele lacking Dbeta segments (the Jbeta1(M6) allele)...
  79. pmc CTLA-4 on alloreactive CD4 T cells interacts with recipient CD80/86 to promote tolerance
    Josef Kurtz
    Bone Marrow Transplantation Section, Transplantation Biology Research Center, Massachusetts General Hospital Harvard Medical School, Boston, MA 02129, USA
    Blood 113:3475-84. 2009
    ..This tolerance is independent of regulatory T cells and culminates in the deletion of directly alloreactive CD4 T cells...
  80. pmc Surface expression of the beta T cell receptor (TCR) chain in the absence of other TCR or CD3 proteins on immature T cells
    H Kishi
    Basel Institute for Immunology, Switzerland
    EMBO J 10:93-100. 1991
    ..The introduction of the beta TCR gene into scid mice resulted in the expression of the beta TCR on the cell surface of thymocytes and induced the expression of CD4 and CD8 co-receptors as well as transcription of the alpha TCR locus...
  81. pmc Junctional region sequences of T-cell receptor beta-chain genes expressed by pathogenic anti-DNA autoantibody-inducing helper T cells from lupus mice: possible selection by cationic autoantigens
    S Adams
    Department of Medicine, New England Medical Center, Boston, MA 02111
    Proc Natl Acad Sci U S A 88:11271-5. 1991
    ..These results offer a clue regarding the nature of the primary autoantigen that may drive the pathogenic autoimmune response in lupus...
  82. pmc Segregation patterns of endogenous mouse mammary tumor viruses in five recombinant inbred strain sets
    B K Lee
    Jackson Laboratory, Bar Harbor, Maine 04609
    J Virol 64:4568-72. 1990
    ..Mtv-30 was genetically mapped to chromosome 12. Additionally, two previously identified Mtv loci, Mtv-14 and Mtv-23, were genetically mapped to chromosome 4 and chromosome 6, respectively...
  83. ncbi Polymorphism of T-cell receptor genes among laboratory and wild mice: diverse origins of laboratory mice
    H Nobuhara
    Department of Maternal and Child Health, Faculty of Medicine, University of Tokyo, Japan
    Immunogenetics 30:405-13. 1989
    ..Analysis of the polymorphisms in these loci suggests that laboratory mice have inherited their genes not only from Mus musculus domesticus, but also from other subspecies, and much more than previously believed from Asian subspecies...
  84. pmc Identification of two murine loci homologous to the v-cbl oncogene
    D C Regnier
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892
    J Virol 63:3678-82. 1989
    ..Analyses of Mus domesticus/M. spretus interspecific backcross mice showed that Cbl-1 maps between the immunoglobulin kappa light chain and T-cell receptor beta chain loci and that Cbl-2 is tightly linked to Thy-1...
  85. ncbi Structure, organization and polymorphism of murine and human T-cell receptor alpha and beta chain gene families
    R K Wilson
    Division of Biology, California Institute of Technology, Pasadena 91125
    Immunol Rev 101:149-72. 1988
  86. ncbi Isolation of cDNA clones encoding T cell-specific membrane-associated proteins
    S M Hedrick
    Nature 308:149-53. 1984
    ..These characteristics suggest that it encodes one chain of the elusive antigen receptor on the surface of T lymphocytes...
  87. ncbi T cell receptor beta chain gene rearrangement and selection during thymocyte development in adult mice
    E C Dudley
    Department of Biology, Yale University, New Haven, Connecticut 06511
    Immunity 1:83-93. 1994
    ....
  88. pmc Immune responsiveness in mutant mice lacking T-cell receptor alpha beta+ cells
    P Chandler
    MRC Clinical Sciences Centre, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK
    Immunology 85:531-7. 1995
    ....
  89. ncbi Localization of the thyrotropin-releasing hormone gene, Trh, on mouse chromosome 6
    M L Roller
    Department of Human Genetics, University of Michigan Medical School, Ann Arbor 48109 0618, USA
    Mamm Genome 6:443-4. 1995
  90. ncbi Control of thymus-independent intestinal intraepithelial lymphocytes by beta 2-microglobulin
    O Neuhaus
    Department of Immunology, University of Ulm, Germany
    Eur J Immunol 25:2332-9. 1995
    ..Regulation of self-reactive thymus-independent i-IEL through beta 2m/ MHC class I may contribute to control of autoreactive immune responses in the intestine...
  91. ncbi Interleukin-7: a cofactor for V(D)J rearrangement of the T cell receptor beta gene
    K Muegge
    Biological Carcinogenesis and Development Program, Program Resources Inc DynCorp, National Cancer Institute Frederick Cancer Research and Development Center, MD 21702
    Science 261:93-5. 1993
    ..These data implicate IL-7, a cytokine that is abundantly expressed in embryonic thymus, in driving gene rearrangement during early T cell development...
  92. ncbi Genetic mapping of two mouse homeobox genes Tlx-1 and Tlx-2 to murine chromosomes 19 and 6
    X Y Wen
    Division of Molecular and Developmental Biology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Genomics 24:388-90. 1994
    ..The proposed gene orders and genetic distances for Tlx-1 and Tlx-2 are centromere 19-Lpc-1-(25.53 cM)-Pltr-4-(5.32 cM)-Tlx-1- (3.19 cM)-Ins-1-(7.45 cM)-Xmv-18, and centromere 6-Tcrb-(12.90 cM)-Mltr-3-(10.75 cM)-Tlx-2-(18.42 cM)-Xmv-6.
  93. ncbi Genetic mapping in human and mouse of the locus encoding TRBP, a protein that binds the TAR region of the human immunodeficiency virus (HIV-1)
    C A Kozak
    Laboratory of Molecular Microbiology, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Genomics 25:66-72. 1995
    ..Western blotting indicates that despite high sequence conservation in human and mouse, the TARBP2 protein differs in apparent size in primate and rodent cells...
  94. pmc Development of CD4+CD8+ thymocytes in RAG-deficient mice through a T cell receptor beta chain-independent pathway
    C J Guidos
    Division of Immunology and Cancer, Hospital for Sick Children Research Institute, Toronto, Canada
    J Exp Med 181:1187-95. 1995
    ..These results suggest an in vivo pathway for DP thymocyte development which is TCR beta chain independent...
  95. ncbi Differential expression of activation markers during tolerance induction by superantigens in T-cell receptor (beta-chain) transgenic mice
    D L Perkins
    Laboratory of Immunogenetics and Transplantation, Brigham and Women s Hospital, Boston, Massachusetts 02115
    Cell Immunol 156:310-21. 1994
    ..However, tolerance induction in our system differs from immunity in terms of the early loss of IL-2R alpha expression, the persistent increased expression of Ly-6A/E, and the lack of development of CD45RBlo memory-type T cells...
  96. ncbi GHRH receptor of little mice contains a missense mutation in the extracellular domain that disrupts receptor function
    P Godfrey
    Department of Biochemistry, Northwestern University, Evanston, Illinois 60208
    Nat Genet 4:227-32. 1993
    ..Similar alterations in GHRHR might explain some isolated GH deficiencies in humans...
  97. ncbi Salmonella typhimurium aroA- infection in gene-targeted immunodeficient mice: major role of CD4+ TCR-alpha beta cells and IFN-gamma in bacterial clearance independent of intracellular location
    J Hess
    Department of Immunology, University of Ulm, Germany
    J Immunol 156:3321-6. 1996
    ..typhimurium SL7207 Hlys and control strains did not differ in beta 2m-/- mutants. This finding argues against direct correlation of cytosolic location of S. typhimurium SL7207 Hlys with CD8+ T cell dependency of protection...
  98. ncbi T cell receptor-gamma, delta-expressing fetal mouse thymocytes are generated without T cell receptor V beta selection
    E Mertsching
    U 184 INSERM, Faculte de Medecine, Strasbourg, France
    Eur J Immunol 26:804-10. 1996
    ..Taken together, these phenotypic and molecular analyses suggest that fetal TCR gamma delta cells have not been subject to TCR beta selection...
  99. ncbi Short-term dexamethasone treatment modulates the expression of the murine TCR zeta gene locus
    S Ronchetti
    Department of Clinical Medicine, Pathology and Pharmacology DMCPF, Perugia University Medical School, Italy
    Cell Immunol 178:124-31. 1997
    ..This newly described effect of DEX may constitute an additional molecular mechanism that contributes to its immunomodulating activity...
  100. ncbi The developmental fate of T cells is critically influenced by TCRgammadelta expression
    J Kang
    Department of Molecular and Cell Biology and Cancer Research Laboratory, University of California at Berkeley, 94720, USA
    Immunity 8:427-38. 1998
    ..T cells from a common precursor cell depends on productive rearrangement and expression of TCRgammadelta or TCRbeta genes, but whether it is an instructive or a stochastic mechanism that is responsible for this process is unclear...
  101. ncbi Chromosomal localization of the human and murine orthologues of the Drosophila smoothened gene
    A Chidambaram
    Intramural Research Support Program, SAIC Frederick, Frederick, Maryland, 21702, USA
    Genomics 53:416-7. 1998

Research Grants21

  1. Defending Against Systemic Mycoses
    GEORGE DEEPE; Fiscal Year: 2008
    ..The collaborative and synergistic effort manifested by this group of investigators will provide new and exciting information regarding prevention and/or treatment of these problematic fungi. ..
  2. PROTECTIVE ANTIGENS FROM HISTOPLASMA CAPSULATUM
    GEORGE DEEPE; Fiscal Year: 2007
    ..abstract_text> ..
  3. The Basis of Functional Variation in Gamma/Delta T cells
    REBECCA O BRIEN; Fiscal Year: 2009
    ..We will also examine the importance to disease outcome of the ability of each subset to produce particular cytokines, induce the death of other cells, and undergo apoptosis. ..
  4. Spontaneous Corneal Inflammation in gd T cell absence
    REBECCA O BRIEN; Fiscal Year: 2005
    ..In addition, we will carryout experiments designed to examine whether the disease is autoimmune, results from bacterial infection, or stems from damage caused by a chemical released from dirty cage litter. ..
  5. Identifying Ligands with Soluble Gamma/Delta TCRs
    REBECCA O BRIEN; Fiscal Year: 2006
    ..3 sTCR. The backup approach involves generation of ligand specific mAbs, identified by their ability to block sTCR/ligand binding, as reagents to affinity-purify the ligand. ..
  6. Factors that modulate thymic output
    Thomas Serwold; Fiscal Year: 2006
    ..In addition, it will be directly relevant to therapies that would involve skewing of T cell development to favor T cells with desired specificities. ..
  7. Immunobiology of NKT cell development and function
    DEREK B SANT apos ANGELO; Fiscal Year: 2010
    ..Understanding key aspects of iNKT cell development will eventually make it possible to alter the function of these cells using gene therapy approaches in an effort to control cancer and other diseases. ..
  8. B1B lymphocytes generate T cell-independent memory
    KISHORE ALUGUPALLI; Fiscal Year: 2009
    ..Understanding the basis for the longevity of the Tl protective responses conferred by B1b cells will provide novel approaches to generate effective vaccines against pathogens expressing Tl antigens. ..
  9. 5th Comparative Medicine Resource Center Director Mtg.
    Stephen Barthold; Fiscal Year: 2008
    ....
  10. Role of Galectin-4 in Colitis
    Atsushi Mizoguchi; Fiscal Year: 2008
    ..These studies will not only enhance understanding of the pathogenic mechanisms of IBD but also provide important information to develop new therapeutic approaches for human IBD. ..
  11. Mechanisms of CTLA-4 Function
    Joonsoo Kang; Fiscal Year: 2007
    ..Understanding these processes is critical for designing novel therapeutic approaches for vaccine development, autoimmune disease, and in transplant and tumor immunology. ..
  12. 3RD ANNUAL MUTANT MOUSE REGIONAL RESOURCE CENTER MEETING
    Stephen Barthold; Fiscal Year: 2003
    ....
  13. Determination of Mechanism of T cell Lineage Committment
    Joonsoo Kang; Fiscal Year: 2006
    ..The long-term objective of this application is to identify genes that determine T cell lineage fate. ..
  14. HELICOBACTER DIAGNOSTIC ASSAYS FOR LABORATORY MICE
    Stephen Barthold; Fiscal Year: 2004
    ..abstract_text> ..
  15. Role of Chemokines in Anthrax Pathogenesis
    Wendy Peters; Fiscal Year: 2004
    ....
  16. IMMUNOBIOLOGY OF POSITIVE SELECTION ON SELF PEPTIDES
    DEREK SANT ANGELO; Fiscal Year: 2003
    ..This work will give us insights into phenomenon such as immunodominance and the link between certain MHC alleles and autoimmunity. ..
  17. Inflammatory Bowel Disease in TCR-Mutant Mice
    Atul Bhan; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable] [unreadable] ..
  18. The function of membrane vesiculation in CTLA-4-mediate*
    Joonsoo Kang; Fiscal Year: 2005
    ..To date there has been limited advancement on the ability to increase CTLA-4 function. The proposed model of CTLA-4 function would provide a novel means to increase CTLA-4-mediated inhibition in vivo. ..
  19. Chemokines and their Receptors in Anthrax Infection
    Wendy Peters; Fiscal Year: 2004
    ..This information may provide a rationale for the use of chemokine/chemokine receptor antagonists in the treatment of anthrax. ..
  20. Regulation of T cell development by SOX13
    Joonsoo Kang; Fiscal Year: 2009
    ..Collectively, the genetic program controlling T cell lineage commitment and maturation will be determined, allowing a better understanding of leukemogenesis. ..