Tcp1

Summary

Gene Symbol: Tcp1
Description: t-complex protein 1
Alias: AI528772, CCT, Cct1, Ccta, TRic, Tcp-1, Tp63, c-cpn, p63, T-complex protein 1 subunit alpha, CCT-alpha, T-complex protein 1 subunit alpha A, T-complex protein 1 subunit alpha B, TCP-1-A, TCP-1-B, TCP-1-alpha, t-complex polypeptide 1, tailless complex polypeptide 1A, tailless complex polypeptide 1B
Species: mouse

Top Publications

  1. ncbi Sub-milliMorgan map of the proximal part of mouse Chromosome 17 including the hybrid sterility 1 gene
    S Gregorova
    Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Prague
    Mamm Genome 7:107-13. 1996
  2. pmc Silencing P2X7 receptor downregulates the expression of TCP-1 involved in lymphoma lymphatic metastasis
    Xudong Jiang
    Department of Clinical Biochemistry, College of Laboratory Diagnostic Medicine, Dalian Medical University, Dalian 116044, China
    Oncotarget 6:42105-17. 2015
  3. ncbi Antibody characterisation of two distinct conformations of the chaperonin-containing TCP-1 from mouse testis
    G Hynes
    CRC Centre for Cell and Molecular Biology, Institute of Cancer Research, Chester Beatty Laboratories, London, UK
    FEBS Lett 358:129-32. 1995
  4. ncbi The chaperonin containing t-complex polypeptide 1 (TCP-1). Multisubunit machinery assisting in protein folding and assembly in the eukaryotic cytosol
    H Kubota
    Cancer Research Campaign Centre for Cell and Molecular Biology, Institute of Cancer Research, Chester Beatty Laboratories, London, England
    Eur J Biochem 230:3-16. 1995
  5. ncbi Identification of six Tcp-1-related genes encoding divergent subunits of the TCP-1-containing chaperonin
    H Kubota
    Institute of Cancer Research, Chester Beatty Laboratories, London, UK
    Curr Biol 4:89-99. 1994
  6. ncbi Individual subunits of the eukaryotic cytosolic chaperonin mediate interactions with binding sites located on subdomains of beta-actin
    G M Hynes
    Institute of Cancer Research, Chester Beatty Laboratories, London SW3 6JB, United Kingdom
    J Biol Chem 275:18985-94. 2000
  7. ncbi The t complex polypeptide 1 (TCP-1) is associated with the cytoplasmic aspect of Golgi membranes
    K Willison
    Institute of Cancer Research, Chester Beatty Laboratories, London, England
    Cell 57:621-32. 1989
  8. ncbi tctex-1: a candidate gene family for a mouse t complex sterility locus
    E Lader
    Department of Zoology, University of Texas, Austin 78712
    Cell 58:969-79. 1989
  9. pmc Disruption of the chaperonin containing TCP-1 function affects protein networks essential for rod outer segment morphogenesis and survival
    Ekaterina Posokhova
    Department of Pharmacology, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Mol Cell Proteomics 10:M110.000570. 2011
  10. ncbi Genetic mapping of the t-complex region on mouse chromosome 17 including the Hybrid sterility-1 gene
    J Forejt
    Institute of Molecular Genetics, Czechoslovak Academy of Sciences, Prague
    Mamm Genome 1:84-91. 1991

Scientific Experts

  • H Kubota
  • M T Loones
  • Sylvie Soues
  • LINDA TOTH
  • Ahmed M Osman
  • Andreas Svanström
  • Xudong Jiang
  • Moses Kasembeli
  • Jinyang Zhang
  • Satyabrata Sinha
  • Louise H Slater
  • Marycharmain Belcastro
  • Maxim Sokolov
  • Matthew D Dun
  • Ekaterina Posokhova
  • Bill B Chen
  • Ralph E Vatner
  • Ross Ridsdale
  • Grant A Challen
  • N Schweifer
  • Julie Grantham
  • K R Willison
  • D P Barlow
  • Yang Song
  • Jia Zeng
  • Ying Kong
  • Shuangyi Ren
  • Yunfei Zuo
  • Ziyi Yang
  • Wenjuan Mao
  • Yi Zhang
  • Judith Frydman
  • Soung Hun Roh
  • David J Tweardy
  • Yunbin Xu
  • Chengjin Ye
  • Min Liao
  • T Kris Eckols
  • Wilson Chun Yu Lau
  • Jiyong Zhou
  • Seongjin Seo
  • Xizhen Ruan
  • Wah Chiu
  • Jie Zan
  • Poppy Datta
  • Deborah T Hung
  • Anne E Clatworthy
  • Erik C Hett
  • Kevin G Mark
  • R Zwart
  • C Li
  • Minjie Lin
  • Jennifer R Glasser
  • R John Aitken
  • Hongman Song
  • Norman A Michaud
  • Rama K Mallampalli
  • Tiffany A Coon
  • Kirill A Martemyanov
  • Nathan D Smith
  • Lauren R Bigley
  • Mark A Baker
  • Brett Nixon
  • LeeAnn Higgins
  • Martin Post
  • Irene Tseu
  • Pramod K Srivastava
  • Jinxia Wang
  • Y Feng
  • G M Hynes
  • L M Silver
  • H Lehrach
  • A K Liou
  • Gemma Martinez
  • Melissa H Little
  • Sean M Grimmond
  • Darrin F Taylor
  • Melissa J Davis
  • Mark Crowe
  • Rohan D Teasdale
  • S Gregorova
  • V Vincek
  • Y P Ding
  • J De Jong
  • H Guo
  • M Lyon
  • S Verhaagh
  • J Klein
  • X Xu
  • W Weinberg

Detail Information

Publications67

  1. ncbi Sub-milliMorgan map of the proximal part of mouse Chromosome 17 including the hybrid sterility 1 gene
    S Gregorova
    Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Prague
    Mamm Genome 7:107-13. 1996
    ..The submilliMorgan map of the T-H2 region revealed significant clustering of (CA)n loci. The clustering, if shown to be a common feature in the mouse genome, may cause gaps in the physical map of the mouse genome...
  2. pmc Silencing P2X7 receptor downregulates the expression of TCP-1 involved in lymphoma lymphatic metastasis
    Xudong Jiang
    Department of Clinical Biochemistry, College of Laboratory Diagnostic Medicine, Dalian Medical University, Dalian 116044, China
    Oncotarget 6:42105-17. 2015
    ..It indicates that TCP-1 may be a crucial downstream molecular of P2X7R and plays a novel role in lymphoid neoplasm metastasis. ..
  3. ncbi Antibody characterisation of two distinct conformations of the chaperonin-containing TCP-1 from mouse testis
    G Hynes
    CRC Centre for Cell and Molecular Biology, Institute of Cancer Research, Chester Beatty Laboratories, London, UK
    FEBS Lett 358:129-32. 1995
    We describe a panel of antibodies specific to individual subunits of the chaperonin-containing TCP-1 (CCT) and one antibody that reacts with all the subunits of CCT...
  4. ncbi The chaperonin containing t-complex polypeptide 1 (TCP-1). Multisubunit machinery assisting in protein folding and assembly in the eukaryotic cytosol
    H Kubota
    Cancer Research Campaign Centre for Cell and Molecular Biology, Institute of Cancer Research, Chester Beatty Laboratories, London, England
    Eur J Biochem 230:3-16. 1995
    ..molecular chaperone, which is abundant in the eukaryotic cytosol and is called the chaperonin containing TCP-1 (CCT), has been shown to assist the folding of some proteins in cytosol...
  5. ncbi Identification of six Tcp-1-related genes encoding divergent subunits of the TCP-1-containing chaperonin
    H Kubota
    Institute of Cancer Research, Chester Beatty Laboratories, London, UK
    Curr Biol 4:89-99. 1994
    ..These chaperonins assist the folding of proteins upon ATP hydrolysis...
  6. ncbi Individual subunits of the eukaryotic cytosolic chaperonin mediate interactions with binding sites located on subdomains of beta-actin
    G M Hynes
    Institute of Cancer Research, Chester Beatty Laboratories, London SW3 6JB, United Kingdom
    J Biol Chem 275:18985-94. 2000
    The chaperonin containing TCP-1 (CCT) of eukaryotic cytosol is composed of eight different subunit species that are proposed to have independent functions in folding its in vivo substrates, the actins and tubulins...
  7. ncbi The t complex polypeptide 1 (TCP-1) is associated with the cytoplasmic aspect of Golgi membranes
    K Willison
    Institute of Cancer Research, Chester Beatty Laboratories, London, England
    Cell 57:621-32. 1989
    The t complex polypeptide 1 (TCP-1) is a protein of unknown function expressed in large amounts during spermatogenesis...
  8. ncbi tctex-1: a candidate gene family for a mouse t complex sterility locus
    E Lader
    Department of Zoology, University of Texas, Austin 78712
    Cell 58:969-79. 1989
    ..The aberrant expression of tctex-1 is solely dependent on the t haplotype genes and occurs only in germ cells. The chromosomal location and pattern of expression of tctex-1 make it a candidate for involvement in male sterility...
  9. pmc Disruption of the chaperonin containing TCP-1 function affects protein networks essential for rod outer segment morphogenesis and survival
    Ekaterina Posokhova
    Department of Pharmacology, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Mol Cell Proteomics 10:M110.000570. 2011
    Type II Chaperonin Containing TCP-1 (CCT, also known as TCP-1 Ring Complex, TRiC) is a multi-subunit molecular machine thought to assist in the folding of ∼ 10% of newly translated cytosolic proteins in eukaryotes...
  10. ncbi Genetic mapping of the t-complex region on mouse chromosome 17 including the Hybrid sterility-1 gene
    J Forejt
    Institute of Molecular Genetics, Czechoslovak Academy of Sciences, Prague
    Mamm Genome 1:84-91. 1991
    ..The limit of resolution of the cross was 0.27 cM. The map distances have been determined for the DNA loci in the T-H-2 interval and the Hst-1 gene was mapped in close vicinity to the D17Rp17 locus...
  11. pmc The molecular chaperone CCT modulates the activity of the actin filament severing and capping protein gelsolin in vitro
    Andreas Svanström
    Department of Chemistry and Molecular Biology, University of Gothenburg, Medicinaregatan 9C, 40530, Gothenburg, Sweden
    Cell Stress Chaperones 21:55-62. 2016
    The oligomeric molecular chaperone CCT is essential for the folding of the highly abundant protein actin, which in its native state forms actin filaments that generate the traction forces required for cell motility...
  12. doi The chaperonin CCTα is required for efficient transcription and replication of rabies virus
    Jinyang Zhang
    Key Laboratory of Animal Virology of Ministry of Agriculture, Zhejiang University, Hangzhou, 310058 State Key Laboratory and Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital, Zhejiang University, Hangzhou, 310003 Research Center of Molecular Medicine of Yunnan Province, Kunming University of Science and Technology, Kunming, 650500, China
    Microbiol Immunol 58:590-9. 2014
    ..Here, it was found that chaperonin containing TCP-1 subunit alpha (CCTα) relocalizes to NBs in RABV-infected cells, and that cotransfection of nucleo- and phospho-proteins of RABV is ..
  13. pmc Essential role of the chaperonin CCT in rod outer segment biogenesis
    Satyabrata Sinha
    Department of Ophthalmology, West Virginia University, Morgantown, West Virginia, United States
    Invest Ophthalmol Vis Sci 55:3775-85. 2014
    While some evidence suggests an essential role for the chaperonin containing t-complex protein 1 (CCT) in ciliogenesis, this function remains poorly understood mechanistically...
  14. pmc Modulation of STAT3 folding and function by TRiC/CCT chaperonin
    Moses Kasembeli
    Section of Infectious Diseases, Department of Medicine, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS Biol 12:e1001844. 2014
    ..Here we show that Stat3 is a novel substrate of the ring-shaped hetero-oligomeric eukaryotic chaperonin, TRiC/CCT, which contributes to its biosynthesis and activity in vitro and in vivo...
  15. pmc CCT chaperonin complex is required for efficient delivery of anthrax toxin into the cytosol of host cells
    Louise H Slater
    Department of Molecular Biology and Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 110:9932-7. 2013
    ..The cytosolic chaperonin complex chaperonin containing t-complex protein 1 (CCT) was identified, and subsequent studies showed that CCT is required for efficient delivery of LF and related fusion ..
  16. pmc Calmodulin antagonizes a calcium-activated SCF ubiquitin E3 ligase subunit, FBXL2, to regulate surfactant homeostasis
    Bill B Chen
    The University of Pittsburgh, Pulmonary, Allergy, and Critical Care Medicine, UPMC Montefiore, NW 628, Department of Medicine, Pittsburgh, PA 15213, USA
    Mol Cell Biol 31:1905-20. 2011
    ..During Pseudomonas aeruginosa infection, SCF (FBXL2) targets the key enzyme, CCTα, for its monoubiquitination and degradation, thereby reducing synthesis of the indispensable membrane and ..
  17. ncbi A structural gene (Tcp-1) within the mouse t complex is separable from effects on tail length and lethality but may be associated with effects on spermatogenesis
    L M Silver
    Genet Res 38:115-23. 1981
  18. doi The tailless complex polypeptide-1 ring complex of the heat shock protein 60 family facilitates cross-priming of CD8 responses specific for chaperoned peptides
    Ralph E Vatner
    Center for Immunotherapy of Cancer and Infectious Diseases and Department of Immunology, University of Connecticut School of Medicine, Farmington, CT 06030 1601, USA
    J Immunol 185:6765-73. 2010
    The tailless complex polypeptide-1 ring complex (TRiC) is a eukaryotic heat shock protein 60 (hsp60) molecule that has been shown to bind N-terminally extended precursors of OVA-derived SIINFEKL in vivo...
  19. ncbi Location of the mouse mast cell protease 7 gene (Mcpt7) to chromosome 17
    M F Gurish
    Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115
    Mamm Genome 5:656-7. 1994
  20. ncbi Two acetyl-CoA acetyltransferase genes located in the t-complex region of mouse chromosome 17 partially overlap the Tcp-1 and Tcp-1x genes
    A Ashworth
    Chester Beatty Laboratories, Institute of Cancer Research, London, United Kingdom
    Genomics 18:195-8. 1993
    ..Both Acat genes appear to be transcribed in several mouse tissues. An ACAT gene also overlaps the TCP1 gene in humans, suggesting that this close linkage may have some functional significance.
  21. ncbi Assignment of the human homologue of the mTRiC-P5 gene (TRIC5) to band 1q23 by fluorescence in situ hybridization
    G Sevigny
    Institute du Cancer de Montréal, Centre de Recherche Louis Charles Simard, Montreal, Quebec, Canada
    Genomics 22:634-6. 1994
    The TCP1 ring complex (TRiC) is a molecular chaperone involved in actin and tubulin folding. Little is known about the components of this complex...
  22. ncbi Genetic maps of polymorphic DNA loci on rat chromosome 1
    Y P Ding
    Arthritis and Rheumatism Branch, National Institutes of Health, Bethesda, Maryland, 20892, USA
    Genomics 36:320-7. 1996
    ..Thirteen gene loci (Myl2, Aldoa, Tnt, Igf2, Prkcg, Cgm4, Calm3, Cgm3, Psbp1, Sa, Hbb, Ins1, and Tcp1) were previously mapped...
  23. ncbi The Lx1 gene maps to mouse chromosome 17 and codes for a protein that is homologous to glucose and polyspecific transmembrane transporters
    N Schweifer
    Research Institute of Molecular Pathology, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Mamm Genome 7:735-40. 1996
    ..Chr 6q has been previously associated with transient neonatal diabetes mellitus and breast cancer...
  24. pmc Elucidation of the subunit orientation in CCT (chaperonin containing TCP1) from the subunit composition of CCT micro-complexes
    A K Liou
    CRC Centre for Cell and Molecular Biology, Institute of Cancer Research, Chester Beatty Laboratories, London, UK
    EMBO J 16:4311-6. 1997
    A collection of chaperonin containing TCP1 (CCT) micro-complexes that are comprised of subsets of the constitutively expressed CCT subunits have been identified. These CCT micro-complexes have mol...
  25. ncbi Characterization of the C3 YAC contig from proximal mouse chromosome 17 and analysis of allelic expression of genes flanking the imprinted Igf2r gene
    N Schweifer
    The Netherlands Cancer Institute H5, Amsterdam
    Genomics 43:285-97. 1997
    ..The remaining genes in this region have previously been shown to be biallelically expressed...
  26. pmc Hsp and chaperone distribution during endochondral bone development in mouse embryo
    M T Loones
    Departement de Biologie, Unité de Génétique Moléculaire, 46 rue d Ulm, Paris, Cedex 05, F 75230, France
    Cell Stress Chaperones 3:237-44. 1998
    ..The involvement of chaperones during these important differentiation steps will be discussed...
  27. ncbi Transcriptional activation of mouse cytosolic chaperonin CCT subunit genes by heat shock factors HSF1 and HSF2
    H Kubota
    HSP Research Institute, Kyoto Research Park, 17 Chudoji Minami machi, Shimogyo ku, Kyoto, Japan
    FEBS Lett 461:125-9. 1999
    The chaperonin containing TCP-1 (CCT) is a eukaryotic molecular chaperone consisting of eight subunit species and assists in the folding of cytosolic proteins...
  28. ncbi A quantitative genetic analysis of slow-wave sleep and rapid-eye movement sleep in CXB recombinant inbred mice
    L A Toth
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Behav Genet 29:329-37. 1999
    ..Probabilities of linkage were not sufficient for declaration of a quantitative trait locus for REMS but were sufficient to warrant further analysis either with additional RI strains or with F2 panels...
  29. pmc The chaperonin containing TCP1 complex (CCT/TRiC) is involved in mediating sperm-oocyte interaction
    Matthew D Dun
    Reproductive Science Group, School of Environmental and Life Sciences, Discipline of Biological Sciences, University of Newcastle, Callaghan, New South Wales 2308, Australia
    J Biol Chem 286:36875-87. 2011
    ..Furthermore, we show that one such multimeric association, comprising the chaperonin-containing TCP1 complex (CCT/TRiC) and a zona-binding protein, zona pellucida-binding protein 2, is present on the surface of ..
  30. ncbi LIS1 regulates CNS lamination by interacting with mNudE, a central component of the centrosome
    Y Feng
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Neuron 28:665-79. 2000
    ..Moreover, misexpression of the LIS1 binding domain of mNudE in Xenopus embryos disrupts the architecture and lamination of the CNS. Thus, LIS1-mNudE interactions may regulate neuronal migration through dynamic reorganization of the MTOC...
  31. ncbi Genetic analysis of the organic cation transporter genes Orct2/Slc22a2 and Orct3/Slc22a3 reduces the critical region for the t haplotype mutant t(w73) to 200 kb
    R Zwart
    Netherlands Cancer Institute, Dept of Molecular Genetics H5, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands
    Mamm Genome 12:734-40. 2001
    ..The results eliminate both Orct2 and Orct3 as candidates and further reduce the critical region containing the t(w73) mutant from 500 kb to 200 kb...
  32. ncbi Fibroblast growth factor receptor 2 (Fgfr2) plays an important role in eyelid and skin formation and patterning
    C Li
    Genetics Development and Disease Branch, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Dev Dyn 222:471-83. 2001
    ..Notably, mutant skin remains thin with decreased hair density after transplantation to wild-type recipients. These data demonstrate an essential role of Fgfr2 in eyelid and skin formation and patterning...
  33. ncbi The cytosolic chaperonin CCT associates to cytoplasmic microtubular structures during mammalian spermiogenesis and to heterochromatin in germline and somatic cells
    Sylvie Soues
    Laboratoire de Biologie Cellulaire, Centre Universitaire des Saints Peres, Universite Rene Descartes Paris V, 45 Rue des Saints Peres, 75270 Paris Cedex 06, France
    Exp Cell Res 288:363-73. 2003
    ..Folding of alpha- and beta-tubulin is mediated by the cytoplasmic chaperonin containing TCP-1 (CCT), highly expressed in testis...
  34. ncbi Identifying the molecular phenotype of renal progenitor cells
    Grant A Challen
    Institute for Molecular Bioscience, Queensland Bioscience Precinct, 306 Carmody Road, The University of Queensland, St Lucia, Brisbane, QLD, 4072, Australia
    J Am Soc Nephrol 15:2344-57. 2004
    ..These findings may assist in the isolation and characterization of potential renal stem cells for use in cellular therapies for kidney disease...
  35. doi Proteomic analysis of mouse thymoma EL4 cells treated with bis(tri-n-butyltin)oxide (TBTO)
    Ahmed M Osman
    National Institute for Public Health and the Environment RIVM, Bilthoven, The Netherlands
    J Immunotoxicol 6:174-83. 2009
    ..We propose that the observed down-regulation of the expression level of ProTalpha in the TBTO-exposed cells could account for the previously reported anti-proliferative effect of TBTO...
  36. doi Functions of membrane binding domain of CTP:phosphocholine cytidylyltransferase in alveolar type II cells
    Ross Ridsdale
    Physiology and Experimental Medicine Program, Hospital for Sick Children Research Institute, 555 University Avenue, Toronto, ON, M5G 1X8 Canada
    Am J Respir Cell Mol Biol 43:74-87. 2010
    ..Thus, the M domain influences membrane binding, cellular distribution, and topology of CCTalpha, but the domain alone is not sufficient to confer CCT activity in alveolar type II cells in vivo.
  37. pmc Nucleotide and amino-acid sequence of human testis-derived TCP1
    C Kirchhoff
    Institute for Hormone and Fertility Research, Hamburg, FRG
    Nucleic Acids Res 18:4247. 1990
  38. ncbi Mapping of six DNA markers on mouse chromosome 17
    J Sertic
    Max Planck Institut fur Biologie, Abteilung Immungenetik, Tubingen, Germany
    Mamm Genome 2:138-42. 1992
  39. ncbi Structure and expression of the gene encoding mouse t-complex polypeptide (Tcp-1)
    H Kubota
    Department of Microbial Genetics, Osaka University, Japan
    Gene 120:207-15. 1992
    ..These results suggest that the expression of the Tcp-1 gene may be regulated spatially and temporally in embryonic and adult mice by transcriptional control or by mRNA stability...
  40. pmc Evolution of the mouse t haplotype: recent and worldwide introgression to Mus musculus
    T Morita
    Department of Microbial Genetics, Osaka University, Japan
    Proc Natl Acad Sci U S A 89:6851-5. 1992
    ..Hence, polymorphisms among t haplotypes including lethality factors have accumulated during this short time period independently in each M. musculus subspecies...
  41. ncbi Nucleotide sequence of a mouse Tcp-1 pseudogene: a nucleotide record for a t complex gene carried by an ancestor of the mouse
    H Kubota
    Department of Microbial Genetics, Osaka University, Japan
    Mamm Genome 2:246-51. 1992
    We have isolated clones of a processed pseudogene of mouse t complex polypeptide 1 (Tcp-1) and determined the nucleotide sequence of the pseudogene. The pseudogene was 1363 bp long and had no intron. The Tcp-1 pseudogene had 88.4% or 88...
  42. ncbi Chromosomal assignments of 17 structural genes and 11 related DNA fragments in rats (Rattus norvegicus) by Southern blot analysis of rat x mouse somatic cell hybrid clones
    M Yasue
    Institute of Laboratory Animals, Faculty of Medicine, Kyoto University, Japan
    Genomics 12:659-64. 1992
    ..Syntenic conservation of the genes among rats, mice, and humans is discussed...
  43. ncbi Genetic mapping of three human homologues of murine t-complex genes localizes TCP10 to 6q27, 15 cM distal to TCP1 and PLG
    H Blanche
    Centre d Etude du Polymorphisme Humain CEPH, Paris, France
    Genomics 12:826-8. 1992
    Human homologues of mouse t-complex genes have been cloned and localized physically to chromosome 6p or 6q. TCP1, TCP10, and PLG are human homologues of genes located in the proximal portion of the t-complex on mouse chromosome 17...
  44. ncbi Localization of the Mas proto-oncogene to a densely marked region of mouse chromosome 17 associated with genomic imprinting
    J A Cebra-Thomas
    Department of Molecular Biology, Princeton University, New Jersey 08544 1014
    Genomics 13:444-6. 1992
    ..The data provide further evidence for the clustering of genes in a 1-Mb region of chromosome 17, with the absence of any identified genes in a nearby region likely to be six times larger...
  45. ncbi Genetic maps of mouse chromosome 17 including 12 new anonymous DNA loci and 25 anchor loci
    J H Nadeau
    Jackson Laboratory, Bar Harbor, Maine 04609
    Genomics 9:78-89. 1991
    ....
  46. pmc Loss of heterozygosity and mitotic linkage maps in the mouse
    V Henson
    Jackson Laboratory, Bar Harbor, ME 04609
    Proc Natl Acad Sci U S A 88:6486-90. 1991
    ....
  47. ncbi The mouse insulin-like growth factor type-2 receptor is imprinted and closely linked to the Tme locus
    D P Barlow
    Research Institute for Molecular Pathology, Vienna, Austria
    Nature 349:84-7. 1991
    ..We also demonstrate that embryos express Igf2r only from the maternal chromosome, and that Tcp-1, Plg and Sod-2 are expressed from both chromosomes. Therefore Igf2r is imprinted and closely linked or identical to Tme...
  48. pmc A novel mouse chromosome 17 hybrid sterility locus: implications for the origin of t haplotypes
    S H Pilder
    Department of Molecular Biology, Princeton University, New Jersey 08544 1014
    Genetics 129:237-46. 1991
    ..domesticus background, and (2) t haplotypes would be transmitted at a ratio closer to Mendelian within the M. spretus background.(ABSTRACT TRUNCATED AT 250 WORDS)..
  49. ncbi Nucleotide sequence of mouse Tcp-1a cDNA
    H Kubota
    Department of Microbial Genetics, Osaka University, Japan
    Gene 105:269-73. 1991
    ..The aa substitution in TCP-1 has occurred at least 20 times faster between t-haplotype and wt than between mouse and human or mouse and Drosophila...
  50. ncbi Tcp-1 gene is not responsible for the maternal lethality effect of Thp mutation in mice
    A Paldi
    Institut Jacques Monod, INSERM U 257, Paris, France
    Dev Biol 143:374-7. 1991
    ..In addition, the paternal and maternal Tcp-1 alleles had identical methylation patterns. These results indicate that Tcp-1 is not responsible for the maternal lethality effect, and therefore is not located at the Tme locus...
  51. ncbi Isolation and characterization of a cDNA clone corresponding to the mouse t-complex gene Tcp-1x
    K Dudley
    Division of Biomolecular Sciences, King s College, Kensington
    Genet Res 57:147-52. 1991
    ..A search of the DNA database has failed to find any significant homology between Tcp-1x and any other sequences apart from Tcp-1...
  52. pmc Genetic and molecular analysis of the proximal region of the mouse t-complex using new molecular probes and partial t-haplotypes
    C A Howard
    Department of Zoology, University of Texas, Austin 78712 1064
    Genetics 126:1103-14. 1990
    ....
  53. ncbi Identification of a locus on mouse chromosome 17 associated with high-affinity choline uptake using BXD recombinant inbred mice and quantitative trait loci analysis
    B J Tarricone
    Department of Psychiatry and Program in Medical Neurobiology, Indiana University School of Medicine, Indianapolis 46202, USA
    Genomics 27:161-4. 1995
    ..Correlations of P < 0.00001 were found between striatal HACU and chromosome 17 markers D17Tu50 and Tcp1. Correlations of P < 0...
  54. ncbi The D17Tu5 locus in the t complex: implications for the origin of t haplotypes and inbred strains
    K Mizuno
    Max Planck Institut fur Biologie, Abteilung Immungenetik, Tubingen, Federal Republic of Germany
    Immunogenetics 30:105-11. 1989
    ..Their distribution between the two species of Mus and among the mice with T haplotypes suggests a relatively recent origin of the t haplotypes...
  55. pmc Evolution of mouse chromosome 17 and the origin of inversions associated with t haplotypes
    M F Hammer
    Department of Biology, Princeton University, NJ 08544
    Proc Natl Acad Sci U S A 86:3261-5. 1989
    ..domesticus and M. abbotti, and that the other three inversions occurred on the separate lineage leading to present-day t haplotypes. Alternative models for the evolution of t haplotypes are discussed in light of these findings...
  56. pmc Chromosomal localization of genes encoding guanine nucleotide-binding protein subunits in mouse and human
    C Blatt
    Weizmann Institute, Rehovoth, Israel
    Proc Natl Acad Sci U S A 85:7642-6. 1988
    ..These mapping assignments will be useful in defining the extent of the G alpha gene family and may help in attempts to correlate specific genetic diseases with genes corresponding to G proteins...
  57. ncbi Extent of the mouse t complex and its inversions shown by in situ hybridization
    M F Lyon
    M R C Radiobiology Unit, Chilton, Didcot, Oxon, UK
    Immunogenetics 27:375-82. 1988
    ..It may soon be possible to correlate the length of the t complex in terms of chromosomal distance with its physical length in megabases...
  58. ncbi Genetic analysis of the proximal portion of the mouse t complex: evidence for a second inversion within t haplotypes
    B Herrmann
    Cell 44:469-76. 1986
    ..This newly described proximal inversion and the previously described distal inversion provide an explanation for the suppression of recombination observed along the length of t haplotype DNA in heterozygous mice...
  59. pmc The human homologue of the mouse t-complex gene, TCP1, is located on chromosome 6 but is not near the HLA region
    K Willison
    Imperial Cancer Research Fund, London, UK
    EMBO J 6:1967-74. 1987
    ..Human TCP1 cDNA clones from both fibrosarcoma and B cell lines confirmed that there was a single expressed gene...
  60. ncbi Location of the t complex on mouse chromosome 17 by in situ hybridization with Tcp-1
    M F Lyon
    Immunogenetics 24:125-7. 1986
  61. ncbi Molecular cloning and sequence analysis of a haploid expressed gene encoding t complex polypeptide 1
    K R Willison
    Cell 44:727-38. 1986
    ..We have cloned the gene for an abundant testicular germ cell protein, t complex polypeptide 1, which has a variant form in t haplotypes, TCP-1A. A cDNA clone, pB1...
  62. ncbi An alpha globin pseudogene is located within the mouse t complex
    H S Fox
    Immunogenetics 19:125-30. 1984
    ..With the use of partial t haplotypes, the alpha-psi 4 sequence has been mapped to the distal end of the t complex. This sequence appears to be closely linked to the tufted locus in the t complex...
  63. ncbi A diversified set of testicular cell proteins specified by genes within the mouse t complex
    L M Silver
    Cell 35:35-45. 1983
    ..The accumulated data suggest a subset of TCP proteins that are most likely to be involved in t haplotype effects on germ cell differentiation and fertility...
  64. ncbi Deletion mapping of the T/t complex: evidence for a second region of critical embryonic genes
    B S Babiarz
    Dev Biol 95:342-51. 1983
    ..This interaction allows the regions of chromosome 17, containing genetic information critical to early mammalian development, to be mapped...
  65. pmc Evidence for unequal crossing over within the mouse T/t complex
    L M Silver
    Proc Natl Acad Sci U S A 77:6077-80. 1980
    ..gene located within the T/t complex on chromosome 17 of the mouse codes for a major cell surface-associated protein p63/6.9. Previously, we identified two structural alleles of this gene which specify alternate forms of the p63/6...
  66. ncbi A major testicular cell protein specified by a mouse T/t complex gene
    L M Silver
    Cell 17:275-84. 1979
  67. ncbi Linkage map of mouse chromosome 17: localization of 27 new DNA markers
    V Vincek
    Max Planck Institut fur Biologie, Abteilung Immungenetik, Tubingen, Federal Republic of Germany
    Genomics 5:773-86. 1989
    ..The distal region of MMU17, on the other hand, is populated by only a few, rather imprecisely mapped markers. Molecular maps are available for most of the H-2 complex and for parts of the t complex...

Research Grants5

  1. Facility renovation to expand mouse barrier space
    LINDA TOTH; Fiscal Year: 2005
    ..This space will not be adequate to support our anticipated continued growth in the areas of infectious disease and toxic challenge and in the need for quarantine of non-vendor rodents. ..
  2. ANALGESIC REGIMENS FOR SURGERY AND INFLAMMATION IN MICE
    LINDA TOTH; Fiscal Year: 2006
    ..The data should reveal new and practical strategies for relief of post-procedural pain in mice. ..
  3. BEHAVIORAL AND PHYSIOLOGIC PATHOBIOLOGY OF MICE
    LINDA TOTH; Fiscal Year: 2006
    ..abstract_text> ..
  4. Sleep and fatigue during renal disease in mice
    LINDA TOTH; Fiscal Year: 2008
    ..Achieving this ambitious goal is feasible given the experience of my laboratory in surveying sleep phenotypes in other studies involving large numbers of mice. [unreadable] [unreadable]..