Tbx2

Summary

Gene Symbol: Tbx2
Description: T-box 2
Alias: T-box transcription factor TBX2, T-box protein 2
Species: mouse

Top Publications

  1. ncbi Segmental expression of the T-box transcription factor, Tbx2, during early somitogenesis
    Zachary Harrelson
    Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, New York, New York, USA
    Dev Dyn 235:3080-4. 2006
  2. doi Neuregulin 1 sustains the gene regulatory network in both trabecular and nontrabecular myocardium
    Donna Lai
    Victor Chang Cardiac Research Institute, Lowy Packer Building, 405 Liverpool St, Darlinghurst 2010, Australia
    Circ Res 107:715-27. 2010
  3. ncbi Loss of Tbx4 blocks hindlimb development and affects vascularization and fusion of the allantois
    L A Naiche
    Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, 701 W 168th Street, New York, NY 10032, USA
    Development 130:2681-93. 2003
  4. ncbi TBX-3, the gene mutated in Ulnar-Mammary Syndrome, is a negative regulator of p19ARF and inhibits senescence
    Thijn R Brummelkamp
    Division of Molecular Carcinogenesis, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    J Biol Chem 277:6567-72. 2002
  5. ncbi Murine Tbx2 contains domains that activate and repress gene transcription
    Christian Paxton
    Department of Animal Science, Iowa State University, Ames, IA 50011, USA
    Gene 283:117-24. 2002
  6. pmc Lethal arrhythmias in Tbx3-deficient mice reveal extreme dosage sensitivity of cardiac conduction system function and homeostasis
    Deborah U Frank
    Department of Pediatrics, University of Utah, Salt Lake City, UT 84158, USA
    Proc Natl Acad Sci U S A 109:E154-63. 2012
  7. pmc Cooperative action of Tbx2 and Nkx2.5 inhibits ANF expression in the atrioventricular canal: implications for cardiac chamber formation
    Petra E M H Habets
    Experimental and Molecular Cardiology Group, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Genes Dev 16:1234-46. 2002
  8. pmc Identification of a Tbx1/Tbx2/Tbx3 genetic pathway governing pharyngeal and arterial pole morphogenesis
    Karim Mesbah
    Developmental Biology Institute of Marseille Luminy, Aix Marseille University, CNRS UMR6216, Marseille, France
    Hum Mol Genet 21:1217-29. 2012
  9. pmc Physical and functional interaction between PML and TBX2 in the establishment of cellular senescence
    Nadine Martin
    Department of Cell Biology and Infection, Nuclear Organisation and Oncogenesis Laboratory, Institut Pasteur, Paris, France
    EMBO J 31:95-109. 2012
  10. ncbi T-box gene products are required for mesenchymal induction of epithelial branching in the embryonic mouse lung
    Judith A Cebra-Thomas
    Department of Biology, Franklin and Marshall College, Lancaster, Pennsylvania, USA
    Dev Dyn 226:82-90. 2003

Research Grants

  1. Regulation of Key Processes in Oocyte Biology
    Martin Matzuk; Fiscal Year: 2007
  2. Defining the Mammalian Intercellular Bridge Interactome
    Martin M Matzuk; Fiscal Year: 2010
  3. ROLE OF TBX6 IN MESODERM PATTERING AND SOMITE FORMATION
    VIRGINIA PAPAIOANNOU; Fiscal Year: 2003
  4. Islet growth in NOD mice tolerant to autoimmune diabetes
    VIRGINIA PAPAIOANNOU; Fiscal Year: 2005
  5. Role of T-box Genes in Mouse Development
    VIRGINIA PAPAIOANNOU; Fiscal Year: 2006
  6. A Screen for Mouse Cardiovascular Morphogenesis Mutants
    Ivan Moskowitz; Fiscal Year: 2008
  7. T-box gene effects on left-right body axis determination
    Virginia E Papaioannou; Fiscal Year: 2010
  8. MOUSE MODELS TO STUDY GONADAL TUMOR DEVELOPMENT
    Martin M Matzuk; Fiscal Year: 2010

Scientific Experts

  • Pamela V Tran
  • Hourinaz Behesti
  • Marco Pontecorvi
  • Yi Hui Chen
  • Elizabeth J Robertson
  • Ivan Moskowitz
  • A K Voss
  • J C Sowden
  • VIRGINIA PAPAIOANNOU
  • Judith A Cebra-Thomas
  • Antonella Galli
  • Martin Matzuk
  • Hiroki Kokubo
  • Francisco Barrionuevo
  • Gerald de Haan
  • Vincent M Christoffels
  • Andreas Kispert
  • Karim Mesbah
  • Chen Leng Cai
  • Antoon F M Moorman
  • Amaal Abrahams
  • Henner F Farin
  • Robert G Kelly
  • Jianjian Zhu
  • Zachary Harrelson
  • Robert J Schwartz
  • Timo H W Lüdtke
  • Sharon Prince
  • Marianne Petry
  • Lei Yang
  • Martijn L Bakker
  • Orit Wolstein
  • Richard P Harvey
  • Loydie A Jerome-Majewska
  • Vincent Wakker
  • Lizhu Lin
  • John P Harris
  • Danielle Mc Laughlin
  • Colin R Goding
  • Mark Oliver Trowe
  • Nataki C Douglas
  • Irfan Saadi
  • Karin Schuster-Gossler
  • Maarten Van Lohuizen
  • Julia Heisig
  • Li Chen
  • Nadine Martin
  • Chun I Wu
  • Preethi Vijayaraj
  • Deborah U Frank
  • Bin Wang
  • Wenjun Zhang
  • Salma Begum
  • Marina Campione
  • Phil Barnett
  • M Sameer Rana
  • Rieko Asai
  • S W Davis
  • Eva Coppola
  • Donna Lai
  • Chantal M Mayers
  • Caroline Medioni
  • S I Agulnik
  • Susan Mackem
  • Julia Norden
  • M Iqbal Parker
  • Manabu Shirai
  • L M Silver
  • Wim T J Aanhaanen
  • Aya Nomura-Kitabayashi
  • Reena Singh
  • Michael P Feneley
  • Janynke F Brons
  • Diane Fatkin
  • Tinke L Vormer
  • D L Chapman
  • Deepak A Venkatesh
  • Kees Jan Boogerd
  • Patrick Hill
  • Edwin P Kirk
  • Sylvia M Evans
  • Wenlai Zhou
  • Sonja Nowotschin
  • Mi Ryoung Song
  • Michael G Rosenfeld
  • Klaudia M Dobrzycka
  • Xiaoxue Zhang
  • Bilada Bilican
  • Lei Bu
  • Ju Chen

Detail Information

Publications97

  1. ncbi Segmental expression of the T-box transcription factor, Tbx2, during early somitogenesis
    Zachary Harrelson
    Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, New York, New York, USA
    Dev Dyn 235:3080-4. 2006
    b>Tbx2 belongs to the T-box transcription factor gene family and is expressed in a variety of tissues and structures throughout development, although not all expression domains have been thoroughly described...
  2. doi Neuregulin 1 sustains the gene regulatory network in both trabecular and nontrabecular myocardium
    Donna Lai
    Victor Chang Cardiac Research Institute, Lowy Packer Building, 405 Liverpool St, Darlinghurst 2010, Australia
    Circ Res 107:715-27. 2010
    ..In development, the membrane-tethered signaling ligand Neuregulin (Nrg)1, expressed in endocardium, is essential for ventricular morphogenesis. In adults, Nrg1 protects against heart failure and can induce cardiomyocytes to divide...
  3. ncbi Loss of Tbx4 blocks hindlimb development and affects vascularization and fusion of the allantois
    L A Naiche
    Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, 701 W 168th Street, New York, NY 10032, USA
    Development 130:2681-93. 2003
    ..The expression of another, closely-linked, T-box gene, Tbx2, is reduced in both the hindlimb and the allantois of Tbx4-mutant embryos prior to the development of overt ..
  4. ncbi TBX-3, the gene mutated in Ulnar-Mammary Syndrome, is a negative regulator of p19ARF and inhibits senescence
    Thijn R Brummelkamp
    Division of Molecular Carcinogenesis, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    J Biol Chem 277:6567-72. 2002
    ..These data suggest that the hypoproliferative features of this genetic disorder may be caused, at least in part, by deregulated expression of p14(ARF)...
  5. ncbi Murine Tbx2 contains domains that activate and repress gene transcription
    Christian Paxton
    Department of Animal Science, Iowa State University, Ames, IA 50011, USA
    Gene 283:117-24. 2002
    ..However, little is known about the domains within Tbx proteins responsible for mediating gene transcription. While Tbx2 is known to repress gene expression, the domain(s) within Tbx2 remains poorly defined...
  6. pmc Lethal arrhythmias in Tbx3-deficient mice reveal extreme dosage sensitivity of cardiac conduction system function and homeostasis
    Deborah U Frank
    Department of Pediatrics, University of Utah, Salt Lake City, UT 84158, USA
    Proc Natl Acad Sci U S A 109:E154-63. 2012
    ..TBX3 and its regulatory targets merit investigation as candidates for human arrhythmias...
  7. pmc Cooperative action of Tbx2 and Nkx2.5 inhibits ANF expression in the atrioventricular canal: implications for cardiac chamber formation
    Petra E M H Habets
    Experimental and Molecular Cardiology Group, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Genes Dev 16:1234-46. 2002
    ..The T-box family member Tbx2, encoding a transcriptional repressor, is expressed in the embryonic myocardium in a pattern mutually exclusive to ..
  8. pmc Identification of a Tbx1/Tbx2/Tbx3 genetic pathway governing pharyngeal and arterial pole morphogenesis
    Karim Mesbah
    Developmental Biology Institute of Marseille Luminy, Aix Marseille University, CNRS UMR6216, Marseille, France
    Hum Mol Genet 21:1217-29. 2012
    ..The T-box family members Tbx2 and Tbx3 are individually required in regulating aspects of OFT and pharyngeal development...
  9. pmc Physical and functional interaction between PML and TBX2 in the establishment of cellular senescence
    Nadine Martin
    Department of Cell Biology and Infection, Nuclear Organisation and Oncogenesis Laboratory, Institut Pasteur, Paris, France
    EMBO J 31:95-109. 2012
    ..Combining gene expression profiling with chromatin-binding analyses and promoter reporter studies, we identify TBX2, a T-box transcription factor frequently overexpressed in cancer, as a novel and direct PML-repressible E2F-target ..
  10. ncbi T-box gene products are required for mesenchymal induction of epithelial branching in the embryonic mouse lung
    Judith A Cebra-Thomas
    Department of Biology, Franklin and Marshall College, Lancaster, Pennsylvania, USA
    Dev Dyn 226:82-90. 2003
    ..If FGF10 is locally replaced in these AS ODN-treated lungs, epithelial branching is restored. These studies provide evidence that the production of branching signals by the lung mesenchyme is mediated by T-box genes...
  11. ncbi Mammary gland, limb and yolk sac defects in mice lacking Tbx3, the gene mutated in human ulnar mammary syndrome
    Todd G Davenport
    Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, 701 W 168th Street, New York, NY 10032, USA
    Development 130:2263-73. 2003
    ....
  12. pmc Tbx3 is required for outflow tract development
    Karim Mesbah
    Developmental Biology Institute of Marseilles Luminy, France
    Circ Res 103:743-50. 2008
    ....
  13. ncbi Tbx2 directly represses the expression of the p21(WAF1) cyclin-dependent kinase inhibitor
    Sharon Prince
    Signalling and Development Laboratory, Marie Curie Research Institute, Oxted, Surrey, United Kingdom
    Cancer Res 64:1669-74. 2004
    ..Some T-box factors have been implicated in cancer; for example, Tbx2 and Tbx3 can suppress replicative senescence, whereas Tbx3 can cooperate with Myc and Ras in cellular ..
  14. ncbi T-box transcription factor Tbx2 represses differentiation and formation of the cardiac chambers
    Vincent M Christoffels
    Experimental and Molecular Cardiology Group, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Dev Dyn 229:763-70. 2004
    ..These regions express Tbx2, a transcriptional repressor. Here, we tested its role in chamber formation...
  15. ncbi Isl1Cre reveals a common Bmp pathway in heart and limb development
    Lei Yang
    Skaggs School of Pharmacy, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Development 133:1575-85. 2006
    ..we find that Bmp signaling in Isl1-expressing progenitors is required for expression of T-box transcription factors Tbx2 and Tbx3 in heart and limb. Tbx3 is required for heart and limb formation, and is mutated in ulnar-mammary syndrome...
  16. ncbi Tbx1 affects asymmetric cardiac morphogenesis by regulating Pitx2 in the secondary heart field
    Sonja Nowotschin
    Department of Molecular Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Development 133:1565-73. 2006
    ..5. The results presented in this study unravel a novel Tbx1-Pitx2 pathway linking Tbx1 to asymmetric cardiac morphogenesis...
  17. ncbi Tbx2 is essential for patterning the atrioventricular canal and for morphogenesis of the outflow tract during heart development
    Zachary Harrelson
    Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Development 131:5041-52. 2004
    b>Tbx2 is a member of the T-box transcription factor gene family, and is expressed in a variety of tissues and organs during embryogenesis...
  18. ncbi Bmp4 in limb bud mesoderm regulates digit pattern by controlling AER development
    Jennifer Selever
    Alkek Institute of Biosciences and Technology, Texas A and M System Health Science Center, Houston, TX 77030, USA
    Dev Biol 276:268-79. 2004
    ..Our data show that Bmp4 in limb mesoderm regulates AER induction and maturation and implicate signaling from the AER in regulation of digit number and identity...
  19. ncbi Bmp2 is essential for cardiac cushion epithelial-mesenchymal transition and myocardial patterning
    Lijiang Ma
    Institute of Biosciences and Technology, Texas A and M University System Health Science Center, 2121 West Holcombe Boulevard, Houston, TX 77030, USA
    Development 132:5601-11. 2005
    ..Lastly, we show that Bmp2 mutants failed to specify the AV myocardium with loss of Tbx2 expression uncovering a myocardial, planar signaling function for Bmp2...
  20. ncbi Tbx3, the ulnar-mammary syndrome gene, and Tbx2 interact in mammary gland development through a p19Arf/p53-independent pathway
    Loydie A Jerome-Majewska
    Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Dev Dyn 234:922-33. 2005
    The closely related T-box genes Tbx2 and Tbx3 are both expressed in the developing mammary glands of mouse embryos and both have been implicated in mammary carcinogenesis. Tbx3 is essential for induction of the mammary placodes in mice...
  21. ncbi A murine model of Holt-Oram syndrome defines roles of the T-box transcription factor Tbx5 in cardiogenesis and disease
    B G Bruneau
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Cell 106:709-21. 2001
    ....
  22. doi Transcription factor Tbx3 is required for the specification of the atrioventricular conduction system
    Martijn L Bakker
    Heart Failure Research Center, Academic Medical Center, Amsterdam, The Netherlands
    Circ Res 102:1340-9. 2008
    ..Our data suggest a mechanism in which Tbx3 represses differentiation into ventricular working myocardium, thereby imposing the conduction system phenotype on cells within its expression domain...
  23. doi Uncoupling Sonic hedgehog control of pattern and expansion of the developing limb bud
    Jianjian Zhu
    Laboratory of Pathology, National Cancer Institute, Bethesda, MD 20892, USA
    Dev Cell 14:624-32. 2008
    ..The progressive loss of digits upon successively earlier Shh removal mirrors this alternating sequence and highlights Shh's role in cell expansion to produce the normal digit complement...
  24. pmc Anchorage-independent growth of pocket protein-deficient murine fibroblasts requires bypass of G2 arrest and can be accomplished by expression of TBX2
    Tinke L Vormer
    Division of Molecular Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Mol Cell Biol 28:7263-73. 2008
    ..pocket proteins, loss of adhesion induces G(1) and G(2) arrest, which could be alleviated by overexpression of the TBX2 oncogene...
  25. ncbi Expression of the T-box family genes, Tbx1-Tbx5, during early mouse development
    D L Chapman
    Department of Genetics and Development, College of Physicans and Surgeons, Columbia University, New York, New York 10032, USA
    Dev Dyn 206:379-90. 1996
    ..expression of different genes in 2 interacting tissues, as in the lung epithelium (Tbx1) and lung mesenchyme (Tbx2-5), and in mammary buds (Tbx3) and mammary stroma (Tbx2)...
  26. pmc Evolution of mouse T-box genes by tandem duplication and cluster dispersion
    S I Agulnik
    Department of Molecular Biology, Princeton University, New Jersey 08544 1014, USA
    Genetics 144:249-54. 1996
    ..This analysis suggests that Tbx4 and Tbx5 are cognate genes that diverged apart from a common ancestral gene during early vertebrate evolution...
  27. doi The Tbx2+ primary myocardium of the atrioventricular canal forms the atrioventricular node and the base of the left ventricle
    Wim T J Aanhaanen
    Heart Failure Research Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Circ Res 104:1267-74. 2009
    ..In the chamber-forming heart, the expression of the T-box transcription factor Tbx2 is restricted to the primary myocardium...
  28. pmc Loss of Tbx2 delays optic vesicle invagination leading to small optic cups
    Hourinaz Behesti
    Developmental Biology Unit, UCL Institute of Child Health, University College London, London, WC1N 1EH, UK
    Dev Biol 333:360-72. 2009
    b>Tbx2 is a T-box transcription factor gene that is dynamically expressed in the presumptive retina during optic vesicle invagination...
  29. pmc Tbx2 controls lung growth by direct repression of the cell cycle inhibitor genes Cdkn1a and Cdkn1b
    Timo H W Lüdtke
    Institute for Molecular Biology, Medizinische Hochschule Hannover, Hannover, Germany
    PLoS Genet 9:e1003189. 2013
    ..Here, we have investigated the function of the patterning T-box transcription factor gene Tbx2 in lung development...
  30. doi Tbx20 interacts with smads to confine tbx2 expression to the atrioventricular canal
    Reena Singh
    Institut fur Molekularbiologie, OE5250, Medizinische Hochschule Hannover, Carl Neuberg Str 1, 30625 Hannover, Germany
    Circ Res 105:442-52. 2009
    ..b>Tbx2 patterns embryonic myocardial cells to form the AVC and suppresses their differentiation into chamber myocardium...
  31. ncbi Smad5 knockout mice die at mid-gestation due to multiple embryonic and extraembryonic defects
    H Chang
    Departments of Pathology, Cell Biology and Molecular and Human Genetics, and Program in Developmental Biology, Baylor College of Medicine, Houston, TX, USA
    Development 126:1631-42. 1999
    ..Despite the expression of Smad5 from gastrulation onwards, and in contrast to knockouts of Smad2 and Smad4, Smad5 only becomes essential later in extraembryonic and embryonic development...
  32. pmc T-box 2, a mediator of Bmp-Smad signaling, induced hyaluronan synthase 2 and Tgfbeta2 expression and endocardial cushion formation
    Manabu Shirai
    Department of Bioscience, National Cardiovascular Center Research Institute, 5 7 1 Fujishirodai, Suita, Osaka 565 8565, Japan
    Proc Natl Acad Sci U S A 106:18604-9. 2009
    During early heart development, Tbx2 gene expression is initiated in the cardiac crescent and then becomes restricted to the outflow tract and the atrioventricular region...
  33. doi The T-box transcription factor Tbx2: its role in development and possible implication in cancer
    Amaal Abrahams
    Faculty of Health Sciences, Department of Human Biology, University of Cape Town, Observatory, Cape Town, South Africa
    IUBMB Life 62:92-102. 2010
    b>Tbx2 is a member of the T-box family of transcription factors that are crucial in embryonic development. Recent studies suggest that T-box factors may also play a role in controlling cell cycle progression and in the genesis of cancer...
  34. ncbi Expression of chick Tbx-2, Tbx-3, and Tbx-5 genes during early heart development: evidence for BMP2 induction of Tbx2
    M Yamada
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, 77030, USA
    Dev Biol 228:95-105. 2000
    Expression patterns of Tbx2, -3, and -5 genes were analyzed during chick embryonic heart development. Transcripts of these three cTbx genes were detected in overlapping patterns in the early cardiac crescent...
  35. pmc The level of BMP4 signaling is critical for the regulation of distinct T-box gene expression domains and growth along the dorso-ventral axis of the optic cup
    Hourinaz Behesti
    Developmental Biology Unit, Institute of Child Health, University College London, 30 Guilford Street, London, WC1N 1EH, UK
    BMC Dev Biol 6:62. 2006
    ..It is not known whether the Tbx5 related genes, Tbx2 and Tbx3, are BMP4 targets in the mammalian retina and whether BMP4 acts at a distance from its site of expression...
  36. ncbi Tbx Genes Specify Posterior Digit Identity through Shh and BMP Signaling
    Takayuki Suzuki
    Graduate School of Biological Sciences, Nara Institute of Science and Technology, 8916 5 Takayama, Ikoma, Nara, 630 0101, Japan
    Dev Cell 6:43-53. 2004
    ..Using the four-digit chick leg as a model, we report here that Tbx2 and Tbx3 specify the digit identities of digits IV and III, respectively...
  37. ncbi An ancient family of embryonically expressed mouse genes sharing a conserved protein motif with the T locus
    R J Bollag
    Department of Molecular Biology, Princeton University, New Jersey 08544
    Nat Genet 7:383-9. 1994
    ..Phylogenetic analysis suggests that at least three T-box genes were present in the common ancestor to vertebrates and invertebrates. Thus, members of the T-box family could have played a role in the evolution of all metazoan organisms...
  38. ncbi T-box genes coordinate regional rates of proliferation and regional specification during cardiogenesis
    Chen Leng Cai
    Skaggs School of Pharmacy, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Development 132:2475-87. 2005
    ..Tbx20-null mice exhibit severely hypoplastic hearts and express Tbx2, which is normally restricted to outflow tract and atrioventricular canal, throughout the heart...
  39. ncbi Expression of Drosophila omb-related T-box genes in the developing human and mouse neural retina
    J C Sowden
    Developmental Biology Unit, Institute of Child Health, University College London, 30 Guilford Street, London, WC1N 1EH, United Kingdom
    Invest Ophthalmol Vis Sci 42:3095-102. 2001
    ..To examine the role of Drosophila optomotor blind (omb)-related T-box genes in development of human and mouse retina...
  40. pmc Expression of Slit and Robo genes in the developing mouse heart
    Caroline Medioni
    Institute of Developmental Biology and Cancer, CNRS UMR 6543, Faculte des Sciences, Parc Valrose Nice, France
    Dev Dyn 239:3303-11. 2010
    ..the homeobox gene Nkx2-5 is required for early ventral restriction of Slit3 and that the T-box transcription factor Tbx2 mediates repression of Slit3 in nonchamber myocardium...
  41. pmc MyoR modulates cardiac conduction by repressing Gata4
    John P Harris
    Department of Internal Medicine Cardiology Division, UT Southwestern Medical Center, Dallas, Texas, USA
    Mol Cell Biol 35:649-61. 2015
    ....
  42. doi Altered Tbx1 gene expression is associated with abnormal oesophageal development in the adriamycin mouse model of oesophageal atresia/tracheo-oesophageal fistula
    Danielle Mc Laughlin
    School of Natural Sciences, Trinity College Dublin, Dublin, Ireland
    Pediatr Surg Int 30:143-9. 2014
    ..Tbx1 and Tbx2 genes modulate pharyngeal and cardiac development, but are also expressed in the developing foregut and are known ..
  43. pmc Inhibition of Sox2-dependent activation of Shh in the ventral diencephalon by Tbx3 is required for formation of the neurohypophysis
    Mark Oliver Trowe
    Institut fur Molekularbiologie, Medizinische Hochschule Hannover, 30625 Hannover, Germany
    Development 140:2299-309. 2013
    b>Tbx2 and Tbx3 are two highly related members of the T-box transcription factor gene family that regulate patterning and differentiation of a number of tissue rudiments in the mouse...
  44. pmc Function of Wnt/β-catenin in counteracting Tcf3 repression through the Tcf3-β-catenin interaction
    Chun I Wu
    Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, IL 60607, USA
    Development 139:2118-29. 2012
    ..We propose that the Tcf/Lef circuit model provides a mechanism downstream of β-catenin stability for controlling the strength of Wnt signaling activity during embryonic development...
  45. pmc MOZ regulates the Tbx1 locus, and Moz mutation partially phenocopies DiGeorge syndrome
    Anne K Voss
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3052, Australia
    Dev Cell 23:652-63. 2012
    ..Our data reveal a molecular mechanism for a specific chromatin modification of the Tbx1 locus intersecting with an environmental determinant, modeling variability in DiGeorge syndrome...
  46. pmc The T-box transcription factors TBX2 and TBX3 in mammary gland development and breast cancer
    Nataki C Douglas
    Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Columbia University Medical Center, New York, NY 10032, USA
    J Mammary Gland Biol Neoplasia 18:143-7. 2013
    b>TBX2 and TBX3, closely related members of the T-box family of transcription factor genes, are expressed in mammary tissue in both humans and mice...
  47. pmc Msx1 and Tbx2 antagonistically regulate Bmp4 expression during the bud-to-cap stage transition in tooth development
    Irfan Saadi
    Center for Regenerative and Developmental Biology, The Forsyth Institute, Cambridge, MA 02142, USA
    Development 140:2697-702. 2013
    ..Ectopic expression of Bmp4 rescues this bud stage arrest. We have identified Tbx2 expression in the dental mesenchyme at bud stage and show that this can be induced by epithelial Bmp4...
  48. pmc Erg is a crucial regulator of endocardial-mesenchymal transformation during cardiac valve morphogenesis
    Preethi Vijayaraj
    Division of Cardiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Development 139:3973-85. 2012
    ..We show that Erg is required for the maintenance of the core EnMT regulatory factors that include Snail1 and Snail2 by binding to their promoter and intronic regions...
  49. pmc Conditional ablation of Ezh2 in murine hearts reveals its essential roles in endocardial cushion formation, cardiomyocyte proliferation and survival
    Li Chen
    Department of Stem Cell Engineering, Basic Research Laboratories, Texas Heart Institute, Houston, Texas, United States of America
    PLoS ONE 7:e31005. 2012
    ..The regulation of Hey2 expression by Ezh2 may be independent of Notch signaling activity. Our work defines an indispensible role of the chromatin remodeling factor Ezh2 in normal cardiovascular development...
  50. pmc The Rho guanine nucleotide exchange factor AKAP13 (BRX) is essential for cardiac development in mice
    Chantal M Mayers
    Program in Reproductive and Adult Endocrinology, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 285:12344-54. 2010
    ..The results suggest that AKAP13 coordinates Galpha(12) and Rho signaling to an essential transcription program in developing cardiomyocytes...
  51. pmc Target gene analysis by microarrays and chromatin immunoprecipitation identifies HEY proteins as highly redundant bHLH repressors
    Julia Heisig
    Developmental Biochemistry, Theodor Boveri Institute, Biocenter, University of Wuerzburg, Wuerzburg, Germany
    PLoS Genet 8:e1002728. 2012
    ..These data clearly establish the three HEY bHLH factors as highly redundant transcriptional repressors in vitro and in vivo, which explains the combinatorial action observed in different tissues with overlapping expression...
  52. pmc Tbx2 terminates shh/fgf signaling in the developing mouse limb bud by direct repression of gremlin1
    Henner F Farin
    Institute for Molecular Biology, Medizinische Hochschule Hannover, Hannover, Germany
    PLoS Genet 9:e1003467. 2013
    ..Here we show that, in Tbx2-deficient hindlimbs, Shh/Fgf4 signaling is prolonged, resulting in increased limb bud size and duplication of digit ..
  53. pmc The T box transcription factor TBX2 promotes epithelial-mesenchymal transition and invasion of normal and malignant breast epithelial cells
    Bin Wang
    Department of Biochemistry and Molecular Biology, Braman Family Breast Cancer Institute, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, Florida, United States of America
    PLoS ONE 7:e41355. 2012
    The T box transcription factor TBX2, a master regulator of organogenesis, is aberrantly amplified in aggressive human epithelial cancers...
  54. pmc Msx1 and Msx2 are required for endothelial-mesenchymal transformation of the atrioventricular cushions and patterning of the atrioventricular myocardium
    Yi Hui Chen
    Department of Biochemistry and Molecular Biology, USC Norris Comprehensive Cancer Center and Hospital, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089 9176, USA
    BMC Dev Biol 8:75. 2008
    ....
  55. doi Ongoing roles of Phox2 homeodomain transcription factors during neuronal differentiation
    Eva Coppola
    Institut de Biologie de l Ecole Normale Supérieure IBENS, Paris, France
    Development 137:4211-20. 2010
    ....
  56. ncbi Conservation of the T-box gene family from Mus musculus to Caenorhabditis elegans
    S I Agulnik
    Department of Molecular Biology, Princeton University, New Jersey 08544 1014, USA
    Genomics 25:214-9. 1995
    ..Phylogenetic analysis suggests that one C. elegans T-box gene may be a direct ortholog of the mouse Tbx2 and Drosophila omb genes...
  57. doi Endoglin is dispensable for angiogenesis, but required for endocardial cushion formation in the midgestation mouse embryo
    Aya Nomura-Kitabayashi
    Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada M4N 3M5
    Dev Biol 335:66-77. 2009
    ....
  58. pmc Molecular mechanisms of pituitary organogenesis: In search of novel regulatory genes
    S W Davis
    University of Michigan Medical School, Ann Arbor, MI 41809 5618, USA
    Mol Cell Endocrinol 323:4-19. 2010
    ..We identified numerous transcription factors that are members of gene families with roles in syndromic or non-syndromic pituitary hormone deficiency. This collection is a rich source for future basic and clinical studies...
  59. doi Endothelin receptor type A expression defines a distinct cardiac subdomain within the heart field and is later implicated in chamber myocardium formation
    Rieko Asai
    Department of Physiological Chemistry and Metabolism, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Development 137:3823-33. 2010
    ..hypoplasia of the ventricular wall, low mitotic activity and decreased Tbx5 expression with reciprocal expansion of Tbx2 expression...
  60. pmc Tbx20 transcription factor is a downstream mediator for bone morphogenetic protein-10 in regulating cardiac ventricular wall development and function
    Wenjun Zhang
    Riley Heart Research Center, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Biol Chem 286:36820-9. 2011
    ..Taken together, our findings demonstrate that the BMP10-Tbx20 signaling cascade is important for ventricular wall development and maturation...
  61. pmc Dynamic expression of Tbx2 and Tbx3 in developing mouse pancreas
    Salma Begum
    Department of Genetics and Development, Columbia University Medical Center, New York, NY 10032, USA
    Gene Expr Patterns 11:476-83. 2011
    b>Tbx2 and Tbx3 are closely related members of the T-box family of transcription factors that are important regulators during normal development as well as major contributors to human developmental syndromes when mutated...
  62. pmc Analysis of mutants with altered shh activity and posterior digit loss supports a biphasic model for shh function as a morphogen and mitogen
    Jianjian Zhu
    Cancer and Developmental Biology Laboratory, CCR, NCI Frederick, Frederick, Maryland, USA
    Dev Dyn 240:1303-10. 2011
    ..Eomesodermin expression, as an independent marker of posterior digit identity, confirmed that proper digit 4 specification requires only the transient phase of Shh activity...
  63. pmc Transcription factor genes Smad4 and Gata4 cooperatively regulate cardiac valve development. [corrected]
    Ivan P Moskowitz
    Department of Pediatrics, University of Chicago, Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 108:4006-11. 2011
    ..We suggest that one determinant of the phenotypic spectrum caused by human GATA4 mutations is differential effects on GATA4/SMAD4 interactions required for endocardial cushion development...
  64. ncbi The del22q11.2 candidate gene Tbx1 regulates branchiomeric myogenesis
    Robert G Kelly
    Department of Genetics and Development, Columbia University, New York, NY 10032, USA
    Hum Mol Genet 13:2829-40. 2004
    ..While no abnormalities in branchiomeric myogenesis were detected in Tbx1(+/-) mice, reduced TBX1 levels may contribute to pharyngeal hypotonia in del22q11.2 patients...
  65. ncbi Mouse thromboxane A2 receptor: cDNA cloning, expression and northern blot analysis
    T Namba
    Department of Pharmacology, Faculty of Medicine, Kyoto University, Japan
    Biochem Biophys Res Commun 184:1197-203. 1992
    ..Northern blot analysis demonstrated that thromboxane A2 receptor mRNA is expressed abundantly in thymus, spleen and lung...
  66. ncbi Cloning and mapping of a human gene (TBX2) sharing a highly conserved protein motif with the Drosophila omb gene
    C Campbell
    Department of Cancer Biology, Cleveland Clinic Foundation, Ohio 44195, USA
    Genomics 28:255-60. 1995
    We have identified and cloned a human gene (TBX2) that exhibits strong sequence homology within a putative DNA binding domain to the drosophila optomotor-blind (omb) gene and lesser homology to the DNA binding domain of the murine ..
  67. ncbi Identification, characterization, and localization to chromosome 17q21-22 of the human TBX2 homolog, member of a conserved developmental gene family
    D J Law
    Human Genome Center, University of Michigan, Ann Arbor 48109 0674, USA
    Mamm Genome 6:793-7. 1995
    ..The Tbx2-related branch includes mouse Mm-Tbx2 and Mm-Tbx3, Drosophila optomotor-blind (Dm-Omb), and Caenorhabditis elegans ..
  68. ncbi Evidence of a role for T-box genes in the evolution of limb morphogenesis and the specification of forelimb/hindlimb identity
    J J Gibson-Brown
    Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Mech Dev 56:93-101. 1996
    ..1996) Dev. Dyn., in press), and four (Tbx2-Tbx5) are represented as two cognate, linked gene pairs (Agulnik et al., (1996), Genetics, in press)...
  69. ncbi Tbx6, a mouse T-Box gene implicated in paraxial mesoderm formation at gastrulation
    D L Chapman
    Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, 701 West 168th Street, New York, New York, 10032, USA
    Dev Biol 180:534-42. 1996
    ..5 days postcoitus, indicating that the continued expression of Tbx6 is directly or indirectly dependent upon Brachyury expression...
  70. ncbi Holt-Oram syndrome is caused by mutations in TBX5, a member of the Brachyury (T) gene family
    Q Y Li
    Department of Genetics, University of Nottingham, Queen s Medical Centre, UK
    Nat Genet 15:21-9. 1997
    ..Tissue in situ hybridization studies on human embryos from days 26 to 52 of gestation reveal expression of TBX5 in heart and limb, consistent with a role in human embryonic development...
  71. ncbi T-box family reunion
    V E Papaioannou
    Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, New York, NY 10032 USA
    Trends Genet 13:212-3. 1997
  72. ncbi Tbt-1, a new T-box transcription factor induced in activated Th1 and CD8+ T cells
    P Shier
    The RW Johnson Pharmaceutical Research Institute, San Diego, CA 92121, USA
    Immunogenetics 51:771-8. 2000
    ..In addition, phylogenetic analyses indicate that Tbt-1 co-evolved with adaptive immune responses. Thus, Tbt-1 is the first T-box transcription factor shown to be specific for Th1 cell differentiation...
  73. pmc Endocardial cushion and myocardial defects after cardiac myocyte-specific conditional deletion of the bone morphogenetic protein receptor ALK3
    Vinciane Gaussin
    Center for Cardiovascular Development, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 99:2878-83. 2002
    ..Hence, ALK3 is essential, beyond just the egg cylinder stage, for myocyte-dependent functions and signals in cardiac organogenesis...
  74. ncbi Critical role of CD81 in cognate T-B cell interactions leading to Th2 responses
    Jun Deng
    Division of Oncology, Department of Medicine, Stanford University Medical Center, CA 94305, USA
    Int Immunol 14:513-23. 2002
    ..Taken together, these results indicate that CD81 expression by T cells greatly enhances cognate T-B cell interactions and greatly augments intracellular activation pathways leading to Th2 polarization...
  75. ncbi The Fused toes (Ft) mouse mutation causes anteroposterior and dorsoventral polydactyly
    Lars Grotewold
    Institut für Entwicklungs und Molekularbiologie der Tiere EMT, Heinrich Heine Universitat, 40225 Dusseldorf, Germany
    Dev Biol 251:129-41. 2002
    ..In addition, our analysis reveals a specific requirement of the genes deleted by the Ft mutation in hindlimb morphogenesis...
  76. ncbi T-box binding protein type two (TBX2) is an immediate early gene target in retinoic-acid-treated B16 murine melanoma cells
    Goran Boskovic
    Department of Biochemistry and Molecular Biology, Joan C Edwards School of Medicine, Marshall University, Huntington, WV 25704, USA
    Exp Cell Res 295:281-9. 2004
    ..One of the genes, tbx2, is a member of T-box nuclear binding proteins that are important morphogens in developing embryos...
  77. pmc Cardiovascular and hematopoietic defects associated with Notch1 activation in embryonic Tie2-expressing populations
    Deepak A Venkatesh
    Center for Molecular Medicine, Maine Medical Center Research Institute, Scarborough, ME 04074, USA
    Circ Res 103:423-31. 2008
    ..Cardiovascular lineages are sensitive to an imbalance in Notch signaling, with aberrant activation reflecting a vascular phenotype comparable to a loss-of-function Notch1 mutation...
  78. pmc A gene(s) for all-trans-retinoic acid-induced forelimb defects mapped and confirmed to murine chromosome 11
    Grace S Lee
    Molecular Toxicology Interdepartmental Program, UCLA School of Public Health, Los Angeles, California 90095, USA
    Genetics 170:345-53. 2005
    ..The human syntenic region of this locus has been previously linked to Meckel syndrome; the phenotype includes postaxial polydactyly, an ectopic digital defect hypothesized to be induced by a common molecular pathway with ectrodactyly...
  79. pmc Beta-catenin directly regulates Islet1 expression in cardiovascular progenitors and is required for multiple aspects of cardiogenesis
    Lizhu Lin
    Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 104:9313-8. 2007
    ..of a number of genes required for pharyngeal arch, outflow tract, and/or atrial septal morphogenesis, including Tbx2, Tbx3, Wnt11, Shh, and Pitx2...
  80. doi Expression of Tbx2 and Tbx3 in the developing hypothalamic-pituitary axis
    Marco Pontecorvi
    Wolfson Institute for Biomedical Research and Department of Biology, University College London, Gower Street, London WC1E 6BT, UK
    Gene Expr Patterns 8:411-7. 2008
    b>TBX2 and TBX3 are transcription factors that belong to the T-box family, members of which play important roles during mammalian embryogenesis...
  81. doi Sox9 is required for invagination of the otic placode in mice
    Francisco Barrionuevo
    Institute of Human Genetics and Anthropology, University of Freiburg, Breisacherstr 33, D 79106 Freiburg, Germany
    Dev Biol 317:213-24. 2008
    ....
  82. doi Msx1 and Msx2 are functional interacting partners of T-box factors in the regulation of Connexin43
    Kees Jan Boogerd
    Department of Anatomy and Embryology, Heart Failure Research Centre, Academic Medical Centre, University of Amsterdam, Meibergdreef 9, 1105AZ Amsterdam, The Netherlands
    Cardiovasc Res 78:485-93. 2008
    T-box factors Tbx2 and Tbx3 play key roles in the development of the cardiac conduction system, atrioventricular canal, and outflow tract of the heart...
  83. ncbi Blimp1 regulates development of the posterior forelimb, caudal pharyngeal arches, heart and sensory vibrissae in mice
    Elizabeth J Robertson
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK
    Development 134:4335-45. 2007
    ..Collectively, the present experiments demonstrate that Blimp1 requirements in diverse cell types are exquisitely dose dependent...
  84. ncbi UV-mediated regulation of the anti-senescence factor Tbx2
    Amaal Abrahams
    Divisions of Medical Biochemistry and Cell Biology, Faculty of Health Sciences, University of Cape Town, Observatory 7925, Cape Town, South Africa
    J Biol Chem 283:2223-30. 2008
    ..Importantly, the highly related T-box factors Tbx2 and Tbx3 can suppress senescence through repressing the cyclin-dependent kinase inhibitors p19(ARF) and p21(WAF1/..
  85. pmc Mutations in cardiac T-box factor gene TBX20 are associated with diverse cardiac pathologies, including defects of septation and valvulogenesis and cardiomyopathy
    Edwin P Kirk
    Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales, 2010, Australia
    Am J Hum Genet 81:280-91. 2007
    ..They provide insights into how mutation of different genes in an interactive regulatory circuit lead to diverse clinical phenotypes, with implications for diagnosis, genetic screening, and patient follow-up...
  86. ncbi The molecular basis of Pallister Hall associated polydactyly
    Patrick Hill
    Institut für Entwicklungs und Molekularbiologie der Tiere, Heinrich Heine Universitat Dusseldorf, Dusseldorf, Germany
    Hum Mol Genet 16:2089-96. 2007
    ..The presented findings help to understand the previously enigmatic emergence of Pallister-Hall associated polydactyly and thus add to the understanding of the pathogenic mode of the action of GLI3(PHS)...
  87. ncbi Hesr1 and Hesr2 regulate atrioventricular boundary formation in the developing heart through the repression of Tbx2
    Hiroki Kokubo
    Division of Mammalian Development, National Institute of Genetics, 1111 Yata, Mishima Shizuoka 411 8540, Japan
    Development 134:747-55. 2007
    ..of the AV canal are poorly defined, and the expression levels of specific markers of the AV myocardium, Bmp2 and Tbx2, are either very weak or undetectable...
  88. ncbi Cell cycle regulation of the T-box transcription factor tbx2
    Bilada Bilican
    Signalling and Development Laboratory, Marie Curie Research Institute, The Chart, Oxted, Surrey, RH8 0TL, UK
    Exp Cell Res 312:2358-66. 2006
    ..b>Tbx2 is a transcriptional repressor implicated in several developmental processes and which has also been implicated in ..
  89. ncbi Defects in pulmonary vasculature and perinatal lung hemorrhage in mice heterozygous null for the Forkhead Box f1 transcription factor
    V V Kalinichenko
    University of Illinois at Chicago, College of Medicine, Department of Molecular Genetics, 900 S Ashland Ave, Chicago, IL 60607 7170, USA
    Dev Biol 235:489-506. 2001
    ..2 (Flk-1), bone morphogenetic protein 4 (Bmp-4), and the transcription factors of the Brachyury T-Box family (Tbx2-Tbx5) and Lung Kruppel-like Factor...
  90. ncbi The forkhead transcription factor Foxf1 is required for differentiation of extra-embryonic and lateral plate mesoderm
    M Mahlapuu
    Department of Molecular Biology, Goteborg University, The Lundberg Laboratory, Medicinaregatan 9C, Box 462, S 405 30 Goteborg, Sweden
    Development 128:155-66. 2001
    ....
  91. ncbi A combined analysis of genomic and primary protein structure defines the phylogenetic relationship of new members if the T-box family
    S Wattler
    Molecular Biology Group, Lower Saxony Institute for Peptide Research GmbH, Hannover, Germany
    Genomics 48:24-33. 1998
    ..We propose a model for the phylogenetic relationships within the gene family that provides a rationale for classifying new T-box genes and facilitates interspecific comparisons...
  92. ncbi A genetic and genomic analysis identifies a cluster of genes associated with hematopoietic cell turnover
    Gerald de Haan
    Department of Stem Cell Biology, University of Groningen, A Deusinglaan 1, 9713 AV Groningen, The Netherlands
    Blood 100:2056-62. 2002
    ..Our data are consistent with the hypothesis that this isolated cell cycle QTL does not result from a mutation in a single gene but rather is a consequence of variable expression of a collection of highly linked genes...
  93. ncbi Serum response factor, an enriched cardiac mesoderm obligatory factor, is a downstream gene target for Tbx genes
    Matthew R Barron
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 280:11816-28. 2005
    ..b>Tbx2, Tbx5, and the cardiac-enriched MYST family histone acetyltransferase TIP60, were observed to be mutual interactive ..
  94. ncbi FGFR1 function at the earliest stages of mouse limb development plays an indispensable role in subsequent autopod morphogenesis
    Cuiling Li
    Genetics of Development and Disease Branch, NIDDK, NIH, 10 9N105, Bethesda, MD 20892, USA
    Development 132:4755-64. 2005
    ....
  95. ncbi The gene encoding the T-box factor Tbx2 is a target for the microphthalmia-associated transcription factor in melanocytes
    S Carreira
    Eukaryotic Transcription Laboratory, Marie Curie Research Institute, Oxted, Surrey RH8 OTL, United Kingdom
    J Biol Chem 275:21920-7. 2000
    ..Here we provide several lines of evidence to suggest that Mitf may regulate the expression of the Tbx2 transcription factor, a member of the T-box family of proteins implicated in the maintenance of cell identity...
  96. ncbi T-Box transcription factor Tbx20 regulates a genetic program for cranial motor neuron cell body migration
    Mi Ryoung Song
    Gene Expression Laboratory, The Salk Institute, La Jolla, CA 92037, USA
    Development 133:4945-55. 2006
    ..Our study suggests that Tbx20 programs a variety of hindbrain motor neurons for migration, independent of directionality, and in facial neurons is a positive regulator of the non-canonical Wnt signaling pathway...
  97. ncbi Disruption of scaffold attachment factor B1 leads to TBX2 up-regulation, lack of p19ARF induction, lack of senescence, and cell immortalization
    Klaudia M Dobrzycka
    Department of Medicine, The Breast Center, Baylor College of Medicine, Houston, TX 77030, USA
    Cancer Res 66:7859-63. 2006
    ..of two proteins involved in immortalization and escape from senescence: low levels of p19(ARF) and high levels of TBX2. Inactivation of TBX2 using a dominant-negative TBX2 resulted in up-regulation of p19(ARF) in SAFB1 knockout MEFs...

Research Grants8

  1. Regulation of Key Processes in Oocyte Biology
    Martin Matzuk; Fiscal Year: 2007
    ..Compromised fertility in knockout models lacking these oocyte-specific genes would demonstrate that these proteins are potential contraceptive targets and possibly mutated in infertile women. ..
  2. Defining the Mammalian Intercellular Bridge Interactome
    Martin M Matzuk; Fiscal Year: 2010
    ..Our proposed Specific Aims will also help us to develop additional high throughput screening assays for the identification of small molecule disruptors of the intercellular bridge. ..
  3. ROLE OF TBX6 IN MESODERM PATTERING AND SOMITE FORMATION
    VIRGINIA PAPAIOANNOU; Fiscal Year: 2003
    ..Specific Aim 4. To isolate and characterize additional members of the Tbx6 subfamily in the mouse with special emphasis on isolating the orthologs of genes known in other species to play a role in mesoderm development. ..
  4. Islet growth in NOD mice tolerant to autoimmune diabetes
    VIRGINIA PAPAIOANNOU; Fiscal Year: 2005
    ..By combining the expertise of the two Pl's to address the problems of islet autoimmunity and beta cell deficiency our proposal will test a combination strategy that may be useful in patients. ..
  5. Role of T-box Genes in Mouse Development
    VIRGINIA PAPAIOANNOU; Fiscal Year: 2006
    ..In this proposal, we focus on the Tbx2 subfamily, Tbx2, Tbx3, Tbx4, and Tbx5 because of their expression in the allantois, a new structure in evolutionary ..
  6. A Screen for Mouse Cardiovascular Morphogenesis Mutants
    Ivan Moskowitz; Fiscal Year: 2008
    ..The candidate will combine clinical expertise with research training to pursue a career as a clinician-scientist in the field of cardiovascular morphogenesis and congenital heart disease. ..
  7. T-box gene effects on left-right body axis determination
    Virginia E Papaioannou; Fiscal Year: 2010
    ..Specific Aim 3. To determine the lineage of cells of the node with respect to their prior expression of Tbx6. ..
  8. MOUSE MODELS TO STUDY GONADAL TUMOR DEVELOPMENT
    Martin M Matzuk; Fiscal Year: 2010
    ..Characterization of these mice will lead to important insights into the development of gonadal cancers in men and women and the roles of several proteins in reproductive physiology. ..