T

Summary

Gene Symbol: T
Description: brachyury
Alias: Bra, D17Mit170, Low, Tl2, Tl3, cou, me75, brachyury protein, brachyury-like 2, brachyury-like 3, low ratio, protein T
Species: mouse

Top Publications

  1. ncbi Cloning of the T gene required in mesoderm formation in the mouse
    B G Herrmann
    Laboratory of Molecular Embryology, National Institute for Medical Research, London, UK
    Nature 343:617-22. 1990
  2. ncbi The T genes in embryogenesis
    B G Herrmann
    Max Planck Institut fur Entwicklungsbiologie, Abteilung Biochemie, Tubingen, Germany
    Trends Genet 10:280-6. 1994
  3. pmc The T protein encoded by Brachyury is a tissue-specific transcription factor
    A Kispert
    Max Planck Institut fur Entwicklungsbiologie, Abteilung Biochemie, Tubingen, Germany
    EMBO J 14:4763-72. 1995
  4. ncbi Murine FGFR-1 is required for early postimplantation growth and axial organization
    C X Deng
    Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts 02115
    Genes Dev 8:3045-57. 1994
  5. ncbi Mixl1 is required for axial mesendoderm morphogenesis and patterning in the murine embryo
    Adam H Hart
    The Walter and Eliza Hall Institute of Medical Research, P O Royal Melbourne Hospital, VIC 3050, Australia
    Development 129:3597-608. 2002
  6. ncbi Mesd encodes an LRP5/6 chaperone essential for specification of mouse embryonic polarity
    Jen Chih Hsieh
    Department of Biochemistry and Cell Biology, Center for Developmental Genetics, State University of New York, Stony Brook, Stony Brook, NY 11794, USA
    Cell 112:355-67. 2003
  7. pmc T-box genes in early embryogenesis
    Chris Showell
    Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Dev Dyn 229:201-18. 2004
  8. pmc Brachyury proteins regulate target genes through modular binding sites in a cooperative fashion
    Thomas Kusch
    Institut fur Genetik, Universitat zu Koln, 50931 Koln, Germany
    Genes Dev 16:518-29. 2002
  9. ncbi Expression pattern of the mouse T gene and its role in mesoderm formation
    D G Wilkinson
    Laboratory of Eukaryotic Molecular Genetics, National Institute for Medical Research, London, UK
    Nature 343:657-9. 1990
  10. ncbi Forebrain and midbrain regions are deleted in Otx2-/- mutants due to a defective anterior neuroectoderm specification during gastrulation
    D Acampora
    International Institute of Genetics and Biophysics CNR, Naples, Italy
    Development 121:3279-90. 1995

Research Grants

Scientific Experts

Detail Information

Publications168 found, 100 shown here

  1. ncbi Cloning of the T gene required in mesoderm formation in the mouse
    B G Herrmann
    Laboratory of Molecular Embryology, National Institute for Medical Research, London, UK
    Nature 343:617-22. 1990
    The murine developmental mutation T identifies an essential gene in mesoderm formation. Embryos lacking normal gene activity fail to form the notochord, the entire posterior region and the allantois, and die at about 10 days of gestation...
  2. ncbi The T genes in embryogenesis
    B G Herrmann
    Max Planck Institut fur Entwicklungsbiologie, Abteilung Biochemie, Tubingen, Germany
    Trends Genet 10:280-6. 1994
    Since its identification in 1927, the mouse T (Brachyury) locus has been implicated in mesoderm formation and notochord differentiation...
  3. pmc The T protein encoded by Brachyury is a tissue-specific transcription factor
    A Kispert
    Max Planck Institut fur Entwicklungsbiologie, Abteilung Biochemie, Tubingen, Germany
    EMBO J 14:4763-72. 1995
    The mouse Brachyury (T) gene is required for differentiation of the notochord and formation of mesoderm during posterior development. Homozygous embryos lacking T activity do not develop a trunk and tail and die in utero...
  4. ncbi Murine FGFR-1 is required for early postimplantation growth and axial organization
    C X Deng
    Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts 02115
    Genes Dev 8:3045-57. 1994
    ..Such abnormalities are unlikely to be caused by intrinsic blocks in mesodermal differentiation, as FGFR-1-deficient ES cell lines form teratomas consisting of many mesodermal cell types...
  5. ncbi Mixl1 is required for axial mesendoderm morphogenesis and patterning in the murine embryo
    Adam H Hart
    The Walter and Eliza Hall Institute of Medical Research, P O Royal Melbourne Hospital, VIC 3050, Australia
    Development 129:3597-608. 2002
    ..Mixl1 is therefore required for the morphogenesis of axial mesoderm, the heart and the gut during embryogenesis...
  6. ncbi Mesd encodes an LRP5/6 chaperone essential for specification of mouse embryonic polarity
    Jen Chih Hsieh
    Department of Biochemistry and Cell Biology, Center for Developmental Genetics, State University of New York, Stony Brook, Stony Brook, NY 11794, USA
    Cell 112:355-67. 2003
    ..between mesd-deficient and wnt3(-)(/)(-) embryos suggest that MESD may function on related members of the low-density lipoprotein receptor (LDLR) family, whose members mediate diverse cellular processes ranging from cargo ..
  7. pmc T-box genes in early embryogenesis
    Chris Showell
    Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Dev Dyn 229:201-18. 2004
    The T-box gene family, encoding related DNA-binding transcriptional regulators, plays an essential role in controlling many aspects of embryogenesis in a wide variety of organisms...
  8. pmc Brachyury proteins regulate target genes through modular binding sites in a cooperative fashion
    Thomas Kusch
    Institut fur Genetik, Universitat zu Koln, 50931 Koln, Germany
    Genes Dev 16:518-29. 2002
    Brachyury proteins, a conserved subgroup of the T domain transcription factors, specify gut and posterior mesoderm derivatives throughout the animal kingdom...
  9. ncbi Expression pattern of the mouse T gene and its role in mesoderm formation
    D G Wilkinson
    Laboratory of Eukaryotic Molecular Genetics, National Institute for Medical Research, London, UK
    Nature 343:657-9. 1990
    ..Genetic evidence indicates that in the mouse the T gene (Brachyury) has a role in the formation and organization of mesoderm...
  10. ncbi Forebrain and midbrain regions are deleted in Otx2-/- mutants due to a defective anterior neuroectoderm specification during gastrulation
    D Acampora
    International Institute of Genetics and Biophysics CNR, Naples, Italy
    Development 121:3279-90. 1995
    ....
  11. ncbi Alterations in gene expression during mesoderm formation and axial patterning in Brachyury (T) embryos
    P Rashbass
    National Institute for Medical Research, London, United Kingdom
    Int J Dev Biol 38:35-44. 1994
    The mouse T (Brachyury) deletion causes defective mesoderm formation and notochord morphogenesis, and abnormalities in the caudal neural tube and somites...
  12. ncbi Disruption of the HNF-4 gene, expressed in visceral endoderm, leads to cell death in embryonic ectoderm and impaired gastrulation of mouse embryos
    W S Chen
    Laboratory of Molecular Cell Biology, Rockefeller University, New York, New York 10021
    Genes Dev 8:2466-77. 1994
    ..Development of embryonic structures is severely impaired. These results demonstrate that the expression of HNF-4 in the visceral endoderm is essential for embryonic ectoderm survival and normal gastrulation...
  13. ncbi Mutation watch: mouse brachyury (T), the T-box gene family, and human disease
    M H Meisler
    Department of Human Genetics, University of Michigan, Ann Arbor 48109 0618, USA
    Mamm Genome 8:799-800. 1997
  14. pmc The retinoic acid-metabolizing enzyme, CYP26A1, is essential for normal hindbrain patterning, vertebral identity, and development of posterior structures
    S Abu-Abed
    Cancer Research Labs, Queen s University, Kingston, Ontario, K7L 3N6, Canada
    Genes Dev 15:226-40. 2001
    ....
  15. ncbi Induction of the mammalian node requires Arkadia function in the extraembryonic lineages
    V Episkopou
    Mammalian Neurogenesis, MRC Clinical Science Centre, Imperial College School of Medicine, Hammersmith Hospital, London, UK
    Nature 410:825-30. 2001
    ..Furthermore, our experiments show that Arkadia interacts genetically with the transforming growth factor (TGF)beta-like factor Nodal, implying that Nodal mediates the function of Arkadia in node induction...
  16. pmc α5β1 integrin-mediated adhesion to fibronectin is required for axis elongation and somitogenesis in mice
    Amparo Girós
    Departament de Bioquimica i Biologia Molecular, Universitat de Valencia, Burjassot, Spain
    PLoS ONE 6:e22002. 2011
    ..Thus, α5β1-mediated adhesion to FN in the PSM regulates the dynamics of membrane protrusions and cell-to-cell communication essential for elongation and segmentation of the body axis...
  17. pmc Avian intervertebral disc arises from rostral sclerotome and lacks a nucleus pulposus: implications for evolution of the vertebrate disc
    Bradley J Bruggeman
    Department of Molecular Genetics and Microbiology, Genetics Institute, University of Florida, College of Medicine, Gainesville, Florida, USA
    Dev Dyn 241:675-83. 2012
    ..A histological analysis of mammalian and nonmammalian organisms suggests that nuclei pulposi are only present in mammals...
  18. ncbi Visceral endoderm-restricted translation of Otx1 mediates recovery of Otx2 requirements for specification of anterior neural plate and normal gastrulation
    D Acampora
    International Institute of Genetics and Biophysics, CNR, Via G Marconi 12, Italy
    Development 125:5091-104. 1998
    ..Moreover, our data lead us to hypothesize that the differential post-transcriptional control existing between VE and epiblast cells may potentially contribute to fundamental regulatory mechanisms required for head specification...
  19. ncbi Genetic dissection of nodal function in patterning the mouse embryo
    L A Lowe
    Experimental Immunology Branch, Division of Basic Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Development 128:1831-43. 2001
    ..We find that nodal signaling is required for correct positioning of the anteroposterior axis, normal anterior and midline patterning, and the left-right asymmetric development of the heart, vasculature, lungs and stomach...
  20. ncbi Loss of Tbx4 blocks hindlimb development and affects vascularization and fusion of the allantois
    L A Naiche
    Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, 701 W 168th Street, New York, NY 10032, USA
    Development 130:2681-93. 2003
    Tbx4 is a member of the T-box family of transcription factor genes, which have been shown to play important roles in development. We have ablated Tbx4 function using targeted mutagenesis in the mouse...
  21. ncbi The Wnt co-receptors Lrp5 and Lrp6 are essential for gastrulation in mice
    Olivia G Kelly
    Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, CA 94720 3200, USA
    Development 131:2803-15. 2004
    ..The effect of reducing, but not eliminating, Wnt signaling in Lrp5(+/-);Lrp6(-/-) mutant embryos provides important insight into the interplay between Wnt, Fgf and Nodal signals in patterning the early mouse embryo...
  22. pmc Redundant roles of Tead1 and Tead2 in notochord development and the regulation of cell proliferation and survival
    Atsushi Sawada
    Laboratory for Embryonic Induction, RIKEN Center for Developmental Biology, 2 2 3 Minatojima minamimachi, Chuo Ku, Kobe, Hyogo 650 0047, Japan
    Mol Cell Biol 28:3177-89. 2008
    ..These results suggest that Tead1 and Tead2 are functionally redundant, use YAP as a major coactivator, and support notochord maintenance as well as cell proliferation and survival in mouse development...
  23. ncbi The winged-helix transcription factor HNF-3 beta is required for notochord development in the mouse embryo
    D C Weinstein
    Laboratory of Molecular Cell Biology, Rockefeller University, New York, New York 10021
    Cell 78:575-88. 1994
    ..Endodermal cells are present but fail to form a gut tube in mutant embryos. These studies indicate that HNF-3 beta has an essential role in the development of axial mesoderm in mouse embryos...
  24. ncbi Brachyury--a gene affecting mouse gastrulation and early organogenesis
    R S Beddington
    Centre for Genome Research, Edinburgh, UK
    Dev Suppl . 1992
    Mouse embryos that are homozygous for the Brachyury (T) deletion die at mid-gestation. They have prominent defects in the notochord, the allantois and the primitive streak...
  25. ncbi The T gene is necessary for normal mesodermal morphogenetic cell movements during gastrulation
    V Wilson
    Laboratory of Mammalian Development, National Institute for Medical Research, London, UK
    Development 121:877-86. 1995
    The T (Brachyury) deletion in mouse is responsible for defective primitive streak and notochord morphogenesis, leading to a failure of the axis to elongate properly posterior to the forelimb bud...
  26. ncbi Wnt-3a regulates somite and tailbud formation in the mouse embryo
    S Takada
    Roche Institute of Molecular Biology, Roche Research Center, Nutley, New Jersey 07110
    Genes Dev 8:174-89. 1994
    ..We suggest that dysmorphology is secondary to the mesodermal and axial defects and that dorsal patterning of the CNS may be regulated by inductive signals arising from surface ectoderm...
  27. ncbi Expression of T protein in the primitive streak is necessary and sufficient for posterior mesoderm movement and somite differentiation
    V Wilson
    Human Genetics Unit, MMC, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, United Kingdom
    Dev Biol 192:45-58. 1997
    A characteristic abnormality of chimeras composed of wildtype and T/T (Brachyury) mutant embryonic stem cells is the aggregation and accumulation of mutant cells in the primitive streak and its descendant, the tail bud (V. Wilson, L...
  28. ncbi The Foxh1-dependent autoregulatory enhancer controls the level of Nodal signals in the mouse embryo
    Dominic P Norris
    Department of Molecular and Cellular Biology, Harvard University, The Biological Laboratories, Cambridge, MA 02138, USA
    Development 129:3455-68. 2002
    ..The feedback loop is thus essential for maintenance of Nodal signals that selectively regulate target gene expression in a temporally and spatially controlled fashion in the mouse embryo...
  29. ncbi Inheritance of T-associated sex reversal in mice
    L L Washburn
    Jackson Laboratory, Bar Harbor, Maine 04609
    Genet Res 56:185-91. 1990
    ..This newly identified gene may be one of the previously defined loci, tda-1 or tda-2...
  30. ncbi A role for Pax-1 as a mediator of notochordal signals during the dorsoventral specification of vertebrae
    H Koseki
    Department of Developmental Biology, Max Planck Institute of Immunobiology, Freiburg, Germany
    Development 119:649-60. 1993
    ..abnormalities in Sd coincide closely, both in time and space, with notochordal changes, as determined by whole-mount T antibody staining...
  31. ncbi Bmpr encodes a type I bone morphogenetic protein receptor that is essential for gastrulation during mouse embryogenesis
    Y Mishina
    Department of Molecular Genetics, University of Texas, M D Anderson Cancer Center, Houston 77030, USA
    Genes Dev 9:3027-37. 1995
    ....
  32. ncbi Rpx: a novel anterior-restricted homeobox gene progressively activated in the prechordal plate, anterior neural plate and Rathke's pouch of the mouse embryo
    E Hermesz
    Laboratory of Mammalian Genes and Development, NICHD, National Institutes of Health, Bethesda, MD 20892, USA
    Development 122:41-52. 1996
    ....
  33. ncbi Distinct regulatory control of the Brachyury gene in axial and non-axial mesoderm suggests separation of mesoderm lineages early in mouse gastrulation
    D Clements
    Department of Biological Sciences, University of Warwick, Coventry, UK
    Mech Dev 56:139-49. 1996
    ..Additionally, the data suggest the possibility that axial and non-axial mesoderm are distinct from the earliest stages of Brachyury expression...
  34. ncbi Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function
    C Chiang
    Laboratory of Mammalian Genes and Development, National Institute of Health, Bethesda, Maryland 20892, USA
    Nature 383:407-13. 1996
    ..Defects in all tissues extend beyond the normal sites of Shh transcription, confirming the proposed role of Shh proteins as an extracellular signal required for the tissue-organizing properties of several vertebrate patterning centres...
  35. ncbi Requirement of the transcription factor GATA4 for heart tube formation and ventral morphogenesis
    J D Molkentin
    Department of Molecular Biology and Oncology, University of Texas Southwestern Medical Center at Dallas, 75235 9148, USA
    Genes Dev 11:1061-72. 1997
    ..We propose that GATA4 is required for the migration or folding morphogenesis of the precardiogenic splanchnic mesodermal cells at the level of the AIP...
  36. ncbi Mesodermal defects and cranial neural crest apoptosis in alpha5 integrin-null embryos
    K L Goh
    Center for Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    Development 124:4309-19. 1997
    ..Mesodermal markers mox-1, Notch-1, Brachyury (T) and Sonic hedgehog (Shh) were expressed in the mutant embryos in a regionally appropriate fashion...
  37. ncbi Hex: a homeobox gene revealing peri-implantation asymmetry in the mouse embryo and an early transient marker of endothelial cell precursors
    P Q Thomas
    MRC National Institute for Medical Research, London, UK
    Development 125:85-94. 1998
    ..Comparison with flk-1 (T. P. Yamaguchi et al...
  38. ncbi Murine cerberus homologue mCer-1: a candidate anterior patterning molecule
    C Biben
    Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia
    Dev Biol 194:135-51. 1998
    ..The data suggest that mCer-1 shares structural, functional, and expression characteristics with Xcer and may participate in patterning the anterior of the embryo and nascent somite region, in part, through a BMP-inhibitory mechanism...
  39. ncbi Smad2 signaling in extraembryonic tissues determines anterior-posterior polarity of the early mouse embryo
    W R Waldrip
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Cell 92:797-808. 1998
    ..Chimera experiments demonstrate these essential activities are contributed by the extraembryonic tissues. Thus, the extraembryonic tissues play critical roles in establishing the body plan during early mouse development...
  40. ncbi Abnormalities of floor plate, notochord and somite differentiation in the loop-tail (Lp) mouse: a model of severe neural tube defects
    N D Greene
    Neural Development Unit, Institute of Child Health, University College, 30 Guilford Street, London, WC1N 1EH, UK
    Mech Dev 73:59-72. 1998
    ..Comparison with other mouse mutants suggests that the enlarged floor plate may be responsible for the failure of neural tube closure in Lp/Lp embryos...
  41. pmc Failure of egg cylinder elongation and mesoderm induction in mouse embryos lacking the tumor suppressor smad2
    M Weinstein
    Laboratory of Biochemistry and Metabolism, National Institute of Diabetes and Digestive and Kidney Diseases, 10 9N105, 10 Center Drive, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 95:9378-83. 1998
    ..Molecular analysis showed that smad2 mutant embryos did not undergo gastrulation or make mesoderm. The results demonstrate that smad2 is required for egg cylinder elongation, gastrulation, and mesoderm induction...
  42. ncbi Defects of the body plan of mutant embryos lacking Lim1, Otx2 or Hnf3beta activity
    S J Kinder
    Embryology Unit, Children s Medical Research Institute, Wentworthville, NSW, Australia
    Int J Dev Biol 45:347-55. 2001
    ..of the expression pattern of genes associated with the posterior germ layer tissues and the primitive streak (T, Wnt3 and Fgf8) and anterior endoderm (Cer1 and Sox17) revealed that the A-P axis of mutant embryos remains aligned ..
  43. pmc FoxH1 (Fast) functions to specify the anterior primitive streak in the mouse
    P A Hoodless
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada M5G 1X5
    Genes Dev 15:1257-71. 2001
    ..These results show that FoxH1 functions in an activin/nodal-Smad signaling pathway that acts upstream of Foxa2 and is required specifically for patterning the APS and node in the mouse...
  44. pmc Rescue of a Wnt mutation by an activated form of LEF-1: regulation of maintenance but not initiation of Brachyury expression
    J Galceran
    Gene Center and Institute of Biochemistry, University of Munich, Feodor Lynenstrasse 25, 81377 Munich, Germany
    Proc Natl Acad Sci U S A 98:8668-73. 2001
    ..Together, these data provide genetic evidence that Lef1 mediates the Wnt3a signal and regulates the stable maintenance of Brachyury expression during gastrulation...
  45. pmc Essential function of histone deacetylase 1 in proliferation control and CDK inhibitor repression
    Gerda Lagger
    Institute of Medical Biochemistry, Division of Molecular Biology, University of Vienna, Vienna Biocenter, Dr Bohr Gasse 9 2, A 1030 Vienna, Austria
    EMBO J 21:2672-81. 2002
    ..Our study provides the first evidence that a histone deacetylase is essential for unrestricted cell proliferation by repressing the expression of selective cell cycle inhibitors...
  46. ncbi Extraembryonic proteases regulate Nodal signalling during gastrulation
    Séverine Beck
    Developmental Biology Group, Swiss Institute for Experimental Cancer Research ISREC, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Nat Cell Biol 4:981-5. 2002
    ..A lack of Spc1 and Spc4 affects both pathways because these proteases also stimulate induction of Bmp4...
  47. pmc TGF beta 1 inhibits Ca2+-calcineurin-mediated activation in thymocytes
    Ramireddy Bommireddy
    Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0524, USA
    J Immunol 170:3645-52. 2003
    ..TGFbeta1 functions to inhibit aberrant T cell expansion by maintaining intracellular calcium concentration levels low enough to prevent a mitogenic response by Ca(2+)-independent stimulatory pathways alone...
  48. ncbi Primitive streak formation in mice is preceded by localized activation of Brachyury and Wnt3
    Jaime A Rivera-Perez
    Department of Genetics, Campus Box 7264, University of North Carolina, Chapel Hill, NC 27599 7264, USA
    Dev Biol 288:363-71. 2005
    ....
  49. ncbi Localization of Brachyury (T) in embryonic and extraembryonic tissues during mouse gastrulation
    Kimberly E Inman
    Department of Anatomy, University of Wisconsin Madison School of Medicine and Public Health, 1300 University Avenue, Madison, WI 53706, USA
    Gene Expr Patterns 6:783-93. 2006
    b>T-box gene family members have important roles during murine embryogenesis, gastrulation, and organogenesis...
  50. pmc The role of microtubule actin cross-linking factor 1 (MACF1) in the Wnt signaling pathway
    Hui Jye Chen
    Department of Pathology and Cell Biology, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Genes Dev 20:1933-45. 2006
    ..Reduction of MACF1 in Wnt-1-expressing P19 cells resulted in decreased T (Brachyury) gene expression, a DNA-binding transcription factor that is a direct target of Wnt/beta-catenin ..
  51. ncbi Axis specification and morphogenesis in the mouse embryo require Nap1, a regulator of WAVE-mediated actin branching
    Andrew S Rakeman
    Developmental Biology Program, Sloan Kettering Institute, 1275 York Avenue, New York, NY 10021, USA
    Development 133:3075-83. 2006
    ..Thus, the Nap1 mutant phenotypes define the crucial roles of Nap1/WAVE-mediated actin regulation in tissue organization and establishment of the body plan of the mammalian embryo...
  52. ncbi Wnt3a/beta-catenin signaling controls posterior body development by coordinating mesoderm formation and segmentation
    William C Dunty
    Cancer and Developmental Biology Laboratory, Center for Cancer Research, National Cancer Institute Frederick, NIH, Frederick, MD 21702, USA
    Development 135:85-94. 2008
    ..and Ripply2 in the PSM through the activation of the Notch ligand Dll1 and the mesodermal transcription factors T and Tbx6...
  53. pmc Mouse prickle1, the homolog of a PCP gene, is essential for epiblast apical-basal polarity
    Hirotaka Tao
    Division for Morphogenesis, National Institute for Basic Biology, Myodaiji, Okazaki, Aichi 444 8585, Japan
    Proc Natl Acad Sci U S A 106:14426-31. 2009
    ..Our results demonstrate a role for mpk1 in AB polarity formation rather than expected role as a PCP gene...
  54. ncbi Expression pattern of the Brachyury gene in whole-mount TWis/TWis mutant embryos
    B G Herrmann
    Max Planck Institut fur Entwicklungsbiologie, Abt Biochemie, Tubingen, Germany
    Development 113:913-7. 1991
    The murine Brachyury (T) gene is required in mesoderm formation. Mutants carrying different T alleles show a graded severity of defects correlated with gene dosage along the body axis...
  55. ncbi A cell autonomous function of Brachyury in T/T embryonic stem cell chimaeras
    P Rashbass
    AFRC Centre for Genome Research, Edinburgh, UK
    Nature 353:348-51. 1991
    Developmental genetics has shown that the Brachyury (T) gene has a key role in mesoderm formation during gastrulation in the mouse...
  56. ncbi The mouse Brachyury gene and mesoderm formation
    K Willison
    Institute of Cancer Research, Chester Beatty Laboratories, London, UK
    Trends Genet 6:104-5. 1990
  57. pmc Saturation germ line mutagenesis of the murine t region including a lethal allele at the quaking locus
    A Shedlovsky
    McArdle Laboratory for Cancer Research, University of Wisconsin, Madison 53706
    Proc Natl Acad Sci U S A 85:180-4. 1988
    ..Although the study of natural variation, including t haplotypes, has yielded some information about the function of these genes, spontaneous variants often exhibit ..
  58. pmc Genetic analysis of a mouse t complex locus that is homologous to a kidney cDNA clone
    E A Mann
    Genetics 114:993-1006. 1986
    ..A study of several t haplotypes resulted in the identification of t-specific alleles of D17Rp17 that map to the proximal half of the t ..
  59. ncbi Sex reversal in XY mice caused by dominant mutation on chromosome 17
    L L Washburn
    Nature 303:338-40. 1983
    ..We present here a third autosomal sex-determining locus. This dominantly inherited trait, tentatively named T-associated sex reversal (gene symbol Tas), is closely linked to or a part of the T/t complex on chromosome 17 of the ..
  60. ncbi Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse
    G Winnier
    Howard Hughes Medical Institute, Vanderbilt University Medical School, Nashville, Tennessee 37232 2175, USA
    Genes Dev 9:2105-16. 1995
    ..Most Bmp-4tm1blh embryos do not proceed beyond the egg cylinder stage, do not express the mesodermal marker T(Brachyury), and show little or no mesodermal differentiation...
  61. ncbi Requirement for Lim1 in head-organizer function
    W Shawlot
    Department of Molecular Genetics, University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Nature 374:425-30. 1995
    ..A partial secondary axis developed anteriorly in some mutant embryos. Lim1 is thus an essential regulator of the vertebrate head organizer...
  62. ncbi A primary requirement for nodal in the formation and maintenance of the primitive streak in the mouse
    F L Conlon
    Department of Biochemistry and Molecular Biology, Harvard University, Cambridge, MA 02138
    Development 120:1919-28. 1994
    ..Data presented in this report demonstrate the involvement of a TGF beta-related molecule in axis formation in mammals...
  63. pmc The Brachyury gene encodes a novel DNA binding protein
    A Kispert
    Max Planck Institut fur Entwicklungsbiologie, Abt Biochemie, Tubingen, Germany
    EMBO J 12:3211-20. 1993
    Brachyury (T) mutant embryos are deficient in mesoderm formation and do not complete axial development. The notochord is most strongly affected...
  64. ncbi Rescue of the tail defect of Brachyury mice
    D Stott
    Max Planck Institut fur Entwicklungsbiologie, Tubingen, Germany
    Genes Dev 7:197-203. 1993
    The mouse Brachyury (T) gene is required for normal development of axial structures. Embryos homozygous for the T mutation show severe deficiencies in mesoderm formation...
  65. ncbi A targeted mouse Otx2 mutation leads to severe defects in gastrulation and formation of axial mesoderm and to deletion of rostral brain
    S L Ang
    Institute de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM Universite Louis Pasteur, Illkirch, C U de Strasbourg, France
    Development 122:243-52. 1996
    ....
  66. ncbi Lack of beta-catenin affects mouse development at gastrulation
    H Haegel
    Max Planck Institut fur Immunbiologie, Freiburg, Germany
    Development 121:3529-37. 1995
    ..Our results demonstrate that, although beta-catenin is expressed rather ubiquitously, it is specifically required in the ectodermal cell layer...
  67. ncbi Anterior primitive endoderm may be responsible for patterning the anterior neural plate in the mouse embryo
    P Thomas
    Laboratory of Mammalian Development, National Institute for Medical Research, Mill Hill, London, UK
    Curr Biol 6:1487-96. 1996
    ....
  68. ncbi Tbx6, a mouse T-Box gene implicated in paraxial mesoderm formation at gastrulation
    D L Chapman
    Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, 701 West 168th Street, New York, New York, 10032, USA
    Dev Biol 180:534-42. 1996
    The T-box genes constitute an evolutionarily conserved family of putative transcription factors which are expressed in discrete domains during embryogenesis, suggesting that they may play roles in inductive interactions...
  69. ncbi Genetic patterning of the developing mouse tail at the time of posterior neuropore closure
    F Gofflot
    Department of Human Anatomy, University of Oxford, United Kingdom
    Dev Dyn 210:431-45. 1997
    ..These results provide a foundation for understanding the mechanisms facilitating transition from primary to secondary body axis formation, as well as the factors involved in defective spinal neurulation...
  70. pmc The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo
    C Sirard
    Amgen Institute, Toronto, Ontario M5G 2C1, Canada
    Genes Dev 12:107-19. 1998
    ..Rescued embryos show severe anterior truncations, indicating a second important role for Smad4 in anterior patterning during embryogenesis...
  71. pmc The type I activin receptor ActRIB is required for egg cylinder organization and gastrulation in the mouse
    Z Gu
    Cardiovascular Research Center, Massachusetts General Hospital East, Department of Medicine, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Genes Dev 12:844-57. 1998
    ..These results provide genetic evidence that ActRIB functions in both epiblast and extraembryonic cells to mediate signals that are required for egg cylinder organization and gastrulation...
  72. pmc The tumor suppressor SMAD4/DPC4 is essential for epiblast proliferation and mesoderm induction in mice
    X Yang
    Laboratory of Biochemistry and Metabolism, 10 9N105, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 95:3667-72. 1998
    ..Altogether, these data demonstrate that SMAD4-mediated signals are required for epiblast proliferation, egg cylinder formation, and mesoderm induction...
  73. ncbi Cripto is required for correct orientation of the anterior-posterior axis in the mouse embryo
    J Ding
    Center for Advanced Biotechnology and Medicine and Dept of Pediatrics, UMDNJ Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    Nature 395:702-7. 1998
    ..Our results indicate that Cripto signalling is essential for the conversion of a proximal-distal asymmetry into an orthogonal anterior-posterior axis...
  74. ncbi The role of the brachyury gene in heart development and left-right specification in the mouse
    T King
    Department of Anatomy and Developmental Biology, St George s Hospital Medical School, London, UK
    Mech Dev 79:29-37. 1998
    ..The mouse brachyury (T) gene encodes a transcription factor which is expressed in the developing notochord and is required for its ..
  75. pmc Targeted disruption of Fgf8 causes failure of cell migration in the gastrulating mouse embryo
    X Sun
    Department of Anatomy and Program in Developmental Biology, School of Medicine, University of California at San Francisco, San Francisco, California 94143 0452 USA
    Genes Dev 13:1834-46. 1999
    ..This study identifies Fgf8 as a gene essential for gastrulation and shows that signaling via FGF8 and/or FGF4 is required for cell migration away from the primitive streak...
  76. ncbi Requirement for Wnt3 in vertebrate axis formation
    P Liu
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Nat Genet 22:361-5. 1999
    ..These studies provide genetic proof for the requirement of Wnt3 in primary axis formation in the mouse...
  77. ncbi The type II activin receptors are essential for egg cylinder growth, gastrulation, and rostral head development in mice
    J Song
    Cardiovascular Research Center, Massachusetts General Hospital, Department of Medicine, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Dev Biol 213:157-69. 1999
    ..These results provide genetic evidence that type II activin receptors are required for egg cylinder growth, primitive streak formation, and rostral head development in mice...
  78. pmc Requirement for beta-catenin in anterior-posterior axis formation in mice
    J Huelsken
    Max Delbrueck Center for Molecular Medicine, 13125 Berlin, Germany
    J Cell Biol 148:567-78. 2000
    ..Our data demonstrate that beta-catenin function is essential in anterior-posterior axis formation in the mouse, and experiments with chimeric embryos show that this function is required in the embryonic ectoderm...
  79. ncbi Eomesodermin is required for mouse trophoblast development and mesoderm formation
    A P Russ
    Wellcome CRC Institute for Cancer and Developmental Biology, and Department of Physiology, University of Cambridge, UK
    Nature 404:95-9. 2000
    ..Here we show that the T-box gene Eomesodermin performs essential functions in both trophoblast development and gastrulation...
  80. ncbi Molecular and embryological characterization of a new transgene-induced null allele of mouse Brachyury locus
    K Abe
    Institute of Molecular Embryology and Genetics, Kumamoto University School of Medicine, Japan
    Mamm Genome 11:238-40. 2000
  81. ncbi Mesodermal patterning defect in mice lacking the Ste20 NCK interacting kinase (NIK)
    Y Xue
    New York University Medical Center, Skirball Institute of Biomolecular Medicine, Department of Pharmacology, NY, NY10016, USA
    Development 128:1559-72. 2001
    ....
  82. pmc The transcription factor FoxH1 (FAST) mediates Nodal signaling during anterior-posterior patterning and node formation in the mouse
    M Yamamoto
    Division of Molecular Biology, Institute for Molecular and Cellular Biology, Osaka University, Japan
    Genes Dev 15:1242-56. 2001
    ..These results indicate that a Nodal-FoxH1 signaling pathway plays a central role in A-P patterning and node formation in the mouse...
  83. ncbi Nodal signalling in the epiblast patterns the early mouse embryo
    J Brennan
    Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, Massachusetts 02138, USA
    Nature 411:965-9. 2001
    ..Our experiments show that proximal-distal and subsequent anterior-posterior polarity of the pregastrulation embryo result from reciprocal cell-cell interactions between the epiblast and the two extra-embryonic tissues...
  84. pmc C57BL/6J-T-associated sex reversal in mice is caused by reduced expression of a Mus domesticus Sry allele
    L L Washburn
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Genetics 158:1675-81. 2001
    C57BL/6J-T-associated sex reversal (B6-TAS) in XY mice results in ovarian development and involves (1) hemizygosity for Tas, a gene located in the region of Chromosome 17 deleted in T(hp) and T(Orl), (2) homozygosity for one or more B6-..
  85. ncbi FGF signaling regulates mesoderm cell fate specification and morphogenetic movement at the primitive streak
    B Ciruna
    Department of Molecular and Medical Genetics, University of Toronto, Ontario, Canada
    Dev Cell 1:37-49. 2001
    ..We propose that modulation of cytoplasmic beta-catenin levels, associated with FGF-induced downregulation of E-cadherin, provides a molecular link between FGF and Wnt signaling pathways at the streak...
  86. ncbi Formation of multiple hearts in mice following deletion of beta-catenin in the embryonic endoderm
    Heiko Lickert
    Department of Molecular Embryology, Max Planck Institute for Immunobiology, Stuebeweg 51, D 79108 Freiburg, Germany
    Dev Cell 3:171-81. 2002
    ..We provide evidence that ablation of beta-catenin in embryonic endoderm changes cell fate from endoderm to precardiac mesoderm, consistent with the existence of bipotential mesendodermal progenitors in mouse embryos...
  87. ncbi Nodal antagonists in the anterior visceral endoderm prevent the formation of multiple primitive streaks
    Aitana Perea-Gomez
    IGBMC CNRS INSERM, Universite Louis Pasteur, 67404 Illkirch Cedex, CU de, Strasbourg, France
    Dev Cell 3:745-56. 2002
    ..Both antagonists are also required for proper patterning of the primitive streak...
  88. ncbi Mouse Mix gene is activated early during differentiation of ES and F9 stem cells and induces endoderm in frog embryos
    Deanna Mohn
    Department of Medicine, Mount Sinai School of Medicine, New York, New York 10128, USA
    Dev Dyn 226:446-59. 2003
    ..Intriguingly, mMix mRNA is detected in a population (T+Flk1+) of cells which may contain hemangioblasts, before the onset of hematopoiesis and activation of hematopoietic ..
  89. ncbi Wnt3a plays a major role in the segmentation clock controlling somitogenesis
    Alexander Aulehla
    Abteilung Entwicklungsbiologie, Max Planck Institut fur Immunbiologie, Stubeweg 51, D 79108, Freiburg, Germany
    Dev Cell 4:395-406. 2003
    ..We propose that the segmentation clock is established by Wnt/beta-catenin signaling via a negative-feedback mechanism and that Wnt3a controls the segmentation process in vertebrates...
  90. pmc The murine Nck SH2/SH3 adaptors are important for the development of mesoderm-derived embryonic structures and for regulating the cellular actin network
    Friedhelm Bladt
    Programme in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada
    Mol Cell Biol 23:4586-97. 2003
    ..These data suggest that the Nck SH2/SH3 adaptors have important functions in the development of mesodermal structures during embryogenesis, potentially linked to a role in cell movement and cytoskeletal organization...
  91. pmc Cell fate decisions within the mouse organizer are governed by graded Nodal signals
    Stephane D Vincent
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Genes Dev 17:1646-62. 2003
    ..These findings conclusively demonstrate that graded Nodal/Smad2 signals govern allocation of the axial mesendoderm precursors that selectively give rise to the ADE and PCP mesoderm...
  92. ncbi Combinatorial activities of Smad2 and Smad3 regulate mesoderm formation and patterning in the mouse embryo
    N Ray Dunn
    Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
    Development 131:1717-28. 2004
    ..Collectively, these results demonstrate that dose-dependent Smad2 and Smad3 signals cooperatively mediate cell fate decisions in the early mouse embryo...
  93. ncbi Targeted deletion of the novel cytoplasmic dynein mD2LIC disrupts the embryonic organiser, formation of the body axes and specification of ventral cell fates
    Amer Ahmed Rana
    Division of Mammalian Development, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Development 131:4999-5007. 2004
    ....
  94. ncbi Canonical Wnt signaling and its antagonist regulate anterior-posterior axis polarization by guiding cell migration in mouse visceral endoderm
    Chiharu Kimura-Yoshida
    Vertebrate Body Plan Group, RIKEN Center for Developmental Biology CDB, 2 2 3 Minatojima minami cho, Chuou ku Kobe, Hyogo 650 0047, Japan
    Dev Cell 9:639-50. 2005
    ..We propose that Wnt/beta-catenin signaling mediates A-P axis polarization by guiding cell migration toward the prospective anterior in the pregastrula mouse embryo...
  95. pmc Dishevelled genes mediate a conserved mammalian PCP pathway to regulate convergent extension during neurulation
    Jianbo Wang
    Department of Pediatrics and Medicine, University of California, San Diego, 9500 Gilman Drive, MC 0627, La Jolla, CA 92093 0627, USA
    Development 133:1767-78. 2006
    ..These results are discussed in light of recent models on PCP and convergent extension...
  96. pmc Nanog binds to Smad1 and blocks bone morphogenetic protein-induced differentiation of embryonic stem cells
    Atsushi Suzuki
    Gene Expression Laboratory, Stem Cell Research Center, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 103:10294-9. 2006
    ..Here, we show that Nanog expression is up-regulated in mouse ES cells by the binding of T (Brachyury) and STAT3 to an enhancer element in the mouse Nanog gene...
  97. ncbi Disruption of early proximodistal patterning and AVE formation in Apc mutants
    Claire Chazaud
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, 600 University Avenue, Toronto, Ontario, M5G 1X5, Canada
    Development 133:3379-87. 2006
    ..In addition, we found that nuclear beta-catenin and other molecular markers are asymmetrically expressed by 4.5 days...
  98. ncbi The nodal precursor acting via activin receptors induces mesoderm by maintaining a source of its convertases and BMP4
    Nadav Ben-Haim
    Ecole Polytechnique Fédérale de Lausanne EPFL ISREC, Chemin des Boveresses 155, CH 1066 Epalinges, Switzerland
    Dev Cell 11:313-23. 2006
    ..Based on mathematical modeling, we discuss how these sequential loops control cell fate...
  99. ncbi Zic2 and Zic3 synergistically control neurulation and segmentation of paraxial mesoderm in mouse embryo
    Takashi Inoue
    Laboratory for Comparative Neurogenesis, RIKEN Brain Science Institute, Wako Shi, Saitama 351 0198, Japan
    Dev Biol 306:669-84. 2007
    ....
  100. pmc Expression of Msgn1 in the presomitic mesoderm is controlled by synergism of WNT signalling and Tbx6
    Lars Wittler
    Department of Developmental Genetics, Max Planck Institute for Molecular Genetics, Berlin, Germany
    EMBO Rep 8:784-9. 2007
    ..factor, which is essential for psm maturation, is regulated by synergism between WNT signalling and the T-box 6 transcription factor, involving a feed-forward control mechanism...
  101. ncbi Distinct and cooperative roles of mammalian Vg1 homologs GDF1 and GDF3 during early embryonic development
    Olov Andersson
    Division of Molecular Neurobiology, Department of Neuroscience, Karolinska Institutet, S 17177 Stockholm, Sweden
    Dev Biol 311:500-11. 2007
    ....

Research Grants19

  1. ROLE OF TBX6 IN MESODERM PATTERING AND SOMITE FORMATION
    VIRGINIA PAPAIOANNOU; Fiscal Year: 2003
    ..Specific Aim 4. To isolate and characterize additional members of the Tbx6 subfamily in the mouse with special emphasis on isolating the orthologs of genes known in other species to play a role in mesoderm development. ..
  2. Islet growth in NOD mice tolerant to autoimmune diabetes
    VIRGINIA PAPAIOANNOU; Fiscal Year: 2005
    ..By combining the expertise of the two Pl's to address the problems of islet autoimmunity and beta cell deficiency our proposal will test a combination strategy that may be useful in patients. ..
  3. Multistep Lymphomagenesis/Tumorigenesis in Transgenic Mice: Protein Kinase Ck2
    David C Seldin; Fiscal Year: 2010
    ..Since CK2 is upregulated in all human tumors that have been studied, CK2 may be a suitable target for cancer treatment. Understanding basic CK2 biology and signaling is a necessary prelude to developing novel therapeutics against it. ..
  4. Role of T-box Genes in Mouse Development
    VIRGINIA PAPAIOANNOU; Fiscal Year: 2006
    The long-term objectives of this project are to understand the evolution of the T-box family of transcription factor genes, to determine their role in embryonic development...
  5. 2008 Basement Membranes Gordon Research Conference
    JEFFREY MINER; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  6. 2006 Gordon Research Conference on Basement Membranes
    JEFFREY MINER; Fiscal Year: 2006
    ..Studies on the genetic analyses of basement membrane functions and the generation of animal models of human basement membrane disorders will be presented. [unreadable] [unreadable] [unreadable] [unreadable]..
  7. ISOLATION OF NOVEL MUTATIONS AFFECTING THE MOUSE EMBRYO
    Kathryn Anderson; Fiscal Year: 2007
    ..The signaling pathways that act in early development also have critical roles in tumor development, so it is likely that these genes identified in this study will define new steps in tumor development and progression. ..
  8. Laminin Alpha5 and Polycystic Kidney Disease
    JEFFREY MINER; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  9. The role of cell polarity in vertebrate limb outgrowth
    Jeffery Barrow; Fiscal Year: 2007
    ..Furthermore he will examine the epistatic relationship between Fgf and Wnt/PCP signaling in regulating cell polarity. [unreadable] [unreadable] [unreadable]..
  10. Mechanisms of Cell/Matrix Interactions in the Kidney
    JEFFREY MINER; Fiscal Year: 2006
    ..Together, the results of these studies will lead to a more complete understanding of cell-matrix interactions in the kidney and could reveal new avenues for diagnosis and treatment of human kidney disease. ..
  11. Epithelial Cell Structure in Vertebrate Development
    Jeffrey D Hildebrand; Fiscal Year: 2010
    ..We will continue to use in vivo studies in mice and in vitro studies in cell culture to understand the molecular mechanisms underlying human birth defects. ..
  12. T-box gene effects on left-right body axis determination
    Virginia E Papaioannou; Fiscal Year: 2010
    ..We will investigate the roles of two T-box transcription factor genes, Brachyury (T) and Tbx6...
  13. ASSEMBLY AND FUNCTION OF BASEMENT MEMBRANE PROTEINS
    JEFFREY MINER; Fiscal Year: 2008
    ..The results of these studies will lead to new information regarding the assembly and function of laminins in the in vivo setting. ..
  14. COLLAGEN IV CHAINS IN KIDNEY DEVELOPMENT AND FUNCTION
    JEFFREY MINER; Fiscal Year: 2002
    ..The results obtained under the auspices of this proposal will have important implication for the pathogenesis of Alport syndrome in man and for approaches current under development that will use gene therapy to treat the human disease. ..
  15. Recessive Mutations that Disrupt Develop of Mouse Embryo
    Kathryn Anderson; Fiscal Year: 2006
    ..All new polymorphic mapping markers and new methods will be made available to the community as electronic resources. ..
  16. Zic3 and the Control of Body Pattern Formation
    STEPHANIE WARE; Fiscal Year: 2005
    ..Through a combination of supervised research, scientific interchange, and selected coursework within this environment, the candidate will obtain the training necessary to transition to an independent investigator. ..
  17. 58TH SOCIETY FOR DEVELOPMENTAL BIOLOGY ANNUAL MEETING
    Kathryn Anderson; Fiscal Year: 2003
    ..The afternoons will be devoted to poster sessions and workshops. A special education symposium will address issues for teachers and for those interested in presenting science to the broader community. ..
  18. VASCULOGENESIS IN THE MURINE ALLANTOIS
    KAREN DOWNS; Fiscal Year: 2002
    ..Further, results of our experiments will shed light on the mechanism of formation of the endothelial cell lineage. ..