Syt1

Summary

Gene Symbol: Syt1
Description: synaptotagmin I
Alias: AW124717, G630098F17Rik, SytI, synaptotagmin-1, p65
Species: mouse

Top Publications

  1. ncbi Synaptic vesicle and synaptic membrane glycoproteins during pre- and postnatal development of mouse cerebral cortex, cerebellum and spinal cord
    C S Mayanil
    Laboratory for Oculo Cerebrospinal Investigation, Children s Memorial Medical Center, Chicago, IL 60614
    Dev Neurosci 15:133-45. 1993
  2. pmc The Janus-faced nature of the C(2)B domain is fundamental for synaptotagmin-1 function
    Mingshan Xue
    Department of Neuroscience, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Nat Struct Mol Biol 15:1160-8. 2008
  3. pmc Differential dependence of phasic transmitter release on synaptotagmin 1 at GABAergic and glutamatergic hippocampal synapses
    Angharad M Kerr
    Physiological Institute I, University of Freiburg, Hermann Herder Strasse 7, D 79104 Freiburg, Germany
    Proc Natl Acad Sci U S A 105:15581-6. 2008
  4. ncbi C-terminal ECFP fusion impairs synaptotagmin 1 function: crowding out synaptotagmin 1
    Weiping Han
    Center for Basic Neuroscience, The Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9111, USA
    J Biol Chem 280:5089-100. 2005
  5. pmc Release of FGF1 and p40 synaptotagmin 1 correlates with their membrane destabilizing ability
    Irene Graziani
    Center for Molecular Medicine, Maine Medical Center Research Institute, 81 Research Drive, Scarborough, ME 04074, USA
    Biochem Biophys Res Commun 349:192-9. 2006
  6. pmc Alcohol induces synaptotagmin 1 expression in neurons via activation of heat shock factor 1
    F P Varodayan
    Department of Neuroscience, Columbia University, 40 Haven Avenue, Room 865, New York, NY 10032, USA
    Neuroscience 193:63-71. 2011
  7. ncbi Inositol-1,3,4,5-tetrakisphosphate binding to C2B domain of IP4BP/synaptotagmin II
    M Fukuda
    Molecular Neurobiology Laboratory, Tsukuba Life Science Center, Ibaraki, Japan
    J Biol Chem 269:29206-11. 1994
  8. pmc Differential but convergent functions of Ca2+ binding to synaptotagmin-1 C2 domains mediate neurotransmitter release
    Ok Ho Shin
    Departments of Neuroscience, Molecular Genetics, Biochemistry, and Pharmacology, and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390 9111, USA
    Proc Natl Acad Sci U S A 106:16469-74. 2009
  9. ncbi SV2B regulates synaptotagmin 1 by direct interaction
    Diana R Lazzell
    WM Keck Center for Learning and Memory, Department of Neurobiology and Anatomy, University of Texas Medical School, Houston, Texas 77030, USA
    J Biol Chem 279:52124-31. 2004
  10. pmc Synaptotagmin arrests the SNARE complex before triggering fast, efficient membrane fusion in response to Ca2+
    Michael C Chicka
    Howard Hughes Medical Institute and Department of Physiology, University of Wisconsin, Madison, 1300 University Avenue, SMI 129, Madison, Wisconsin 53706, USA
    Nat Struct Mol Biol 15:827-35. 2008

Research Grants

  1. ALZHEIMER PATHOPHYSIOLOGY IN HUMAN CATARACT FORMATION
    PETER FREDERIKSE; Fiscal Year: 2002
  2. BDNF in depression, antidepressant action, and memory
    CRAIG POWELL; Fiscal Year: 2007
  3. Alzheimer disease biomarkers in lens
    Peter H Frederikse; Fiscal Year: 2010

Scientific Experts

  • C B Gundersen
  • Zhanyang Yu
  • Ralf Mohrmann
  • Uwe Ernsberger
  • Vivek Gautam
  • Peng Cao
  • PETER FREDERIKSE
  • Jakob B Sørensen
  • Thomas Voets
  • CRAIG POWELL
  • Mitsunori Fukuda
  • Maryline Beurg
  • J Lang
  • Thomas C Sudhof
  • Edwin R Chapman
  • Ok Ho Shin
  • Christian Rosenmund
  • Josep Rizo
  • Jun Xu
  • Zhiping P Pang
  • Sung E Kwon
  • Jeong Seop Rhee
  • Jun Yao
  • Min Dong
  • Anton Maximov
  • Tei ichi Nishiki
  • Mingshan Xue
  • Yu Fan Liu
  • Taulant Bacaj
  • Matthijs Verhage
  • Xiaofei Yang
  • Ellen Reisinger
  • Huisheng Liu
  • Nils Brose
  • Heidi de Wit
  • Akira Kuzuya
  • LiYi Li
  • T C Sudhof
  • Arthur P H de Jong
  • Qiangjun Zhou
  • Ning Zhang
  • Stefan H Gerber
  • Robert E Hammer
  • Alexander C Meyer
  • Jutta Stubbusch
  • Jens Rettig
  • Jiong Tang
  • Li Hua Yao
  • Xiu Lan Zhu
  • Daniel Parisotto
  • Wei Xu
  • Zhao Wang
  • Yukiko Usami
  • Jose Alfredo Mendez
  • F P Varodayan
  • George J Augustine
  • Takaaki Nishimoto
  • Jon D Gaffaney
  • Mark W Musch
  • Jia Yao
  • Jacqueline Blundell
  • Pal Stenmark
  • Hiroyasu Watanabe
  • Andrea Burgalossi
  • Chaofeng Han
  • Timothy K Craig
  • Chauying J Jen
  • Jih Ing Chuang
  • Lung Yu
  • Fong Sen Wu
  • Yu Min Kuo
  • Hsiun Ing Chen
  • Michael C Chicka
  • Jean Sébastien Schonn
  • Zhi Tao Hu
  • Angharad M Kerr
  • Jong Cheol Rah
  • Agnieszka Masztalerz
  • Michael A Fox
  • Gabor Nagy
  • J Rizo
  • Yi Lisa Lyu
  • Irene Graziani
  • Ulf Matti
  • THOMAS SUDHOF
  • Weiping Han
  • Dieter Bruns
  • Catherine R Borden
  • Massimiliano Stagi
  • Darren M Hutt

Detail Information

Publications100

  1. ncbi Synaptic vesicle and synaptic membrane glycoproteins during pre- and postnatal development of mouse cerebral cortex, cerebellum and spinal cord
    C S Mayanil
    Laboratory for Oculo Cerebrospinal Investigation, Children s Memorial Medical Center, Chicago, IL 60614
    Dev Neurosci 15:133-45. 1993
    ..The developmental expression of synaptotagmin 1, a well characterized glycoprotein of synaptic vesicle, was determined by immunoblots analysis...
  2. pmc The Janus-faced nature of the C(2)B domain is fundamental for synaptotagmin-1 function
    Mingshan Xue
    Department of Neuroscience, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Nat Struct Mol Biol 15:1160-8. 2008
    ....
  3. pmc Differential dependence of phasic transmitter release on synaptotagmin 1 at GABAergic and glutamatergic hippocampal synapses
    Angharad M Kerr
    Physiological Institute I, University of Freiburg, Hermann Herder Strasse 7, D 79104 Freiburg, Germany
    Proc Natl Acad Sci U S A 105:15581-6. 2008
    Previous studies revealed that synaptotagmin 1 is the major Ca(2+) sensor for fast synchronous transmitter release at excitatory synapses...
  4. ncbi C-terminal ECFP fusion impairs synaptotagmin 1 function: crowding out synaptotagmin 1
    Weiping Han
    Center for Basic Neuroscience, The Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9111, USA
    J Biol Chem 280:5089-100. 2005
    To allow the monitoring of synaptotagmin 1 trafficking in vivo, we generated transgenic mice expressing a synaptotagmin 1-enhanced cyan fluorescent protein (ECFP) fusion protein under control of the Thy1 promoter...
  5. pmc Release of FGF1 and p40 synaptotagmin 1 correlates with their membrane destabilizing ability
    Irene Graziani
    Center for Molecular Medicine, Maine Medical Center Research Institute, 81 Research Drive, Scarborough, ME 04074, USA
    Biochem Biophys Res Commun 349:192-9. 2006
    ..FGF1, p40 Syt1, and S100A13 induced destabilization of liposomes composed of acidic but not of zwitterionic pL...
  6. pmc Alcohol induces synaptotagmin 1 expression in neurons via activation of heat shock factor 1
    F P Varodayan
    Department of Neuroscience, Columbia University, 40 Haven Avenue, Room 865, New York, NY 10032, USA
    Neuroscience 193:63-71. 2011
    ..we investigated the effects of acute alcohol exposure (1-24 h) on the expression of the gene encoding synaptotagmin 1 (Syt1), a synaptic protein that binds calcium to directly trigger vesicle fusion...
  7. ncbi Inositol-1,3,4,5-tetrakisphosphate binding to C2B domain of IP4BP/synaptotagmin II
    M Fukuda
    Molecular Neurobiology Laboratory, Tsukuba Life Science Center, Ibaraki, Japan
    J Biol Chem 269:29206-11. 1994
    ..Our data suggest that the C2B domain of synaptotogamin is the inositol polyphosphate sensor at the synaptic vesicle and may be involved in synaptic function...
  8. pmc Differential but convergent functions of Ca2+ binding to synaptotagmin-1 C2 domains mediate neurotransmitter release
    Ok Ho Shin
    Departments of Neuroscience, Molecular Genetics, Biochemistry, and Pharmacology, and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390 9111, USA
    Proc Natl Acad Sci U S A 106:16469-74. 2009
    ....
  9. ncbi SV2B regulates synaptotagmin 1 by direct interaction
    Diana R Lazzell
    WM Keck Center for Learning and Memory, Department of Neurobiology and Anatomy, University of Texas Medical School, Houston, Texas 77030, USA
    J Biol Chem 279:52124-31. 2004
    ..Previous studies found that SV2A, but not SV2B, can interact with the cytoplasmic domain of synaptotagmin 1, a Ca2+ sensor for synaptic vesicle exocytosis...
  10. pmc Synaptotagmin arrests the SNARE complex before triggering fast, efficient membrane fusion in response to Ca2+
    Michael C Chicka
    Howard Hughes Medical Institute and Department of Physiology, University of Wisconsin, Madison, 1300 University Avenue, SMI 129, Madison, Wisconsin 53706, USA
    Nat Struct Mol Biol 15:827-35. 2008
    ..These findings demonstrate that Ca(2+) converts synaptotagmin from a clamp to a trigger for exocytosis...
  11. pmc Functional dissection of the interactions of stonin 2 with the adaptor complex AP-2 and synaptotagmin
    Kristin Walther
    Department of Biochemistry II, Zentrum für Biochemie and Molekulare Zellbiologie, University of Gottingen, Humboldtallee 23, 37073 Gottingen, Germany
    Proc Natl Acad Sci U S A 101:964-9. 2004
    ..We hypothesize that stonin 2 may function as an AP-2-dependent sorting adaptor for synaptic vesicle recycling...
  12. doi Synaptotagmin-1 docks secretory vesicles to syntaxin-1/SNAP-25 acceptor complexes
    Heidi de Wit
    Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, Vrije Universiteit Amsterdam and VU Medical Center, 1081 HV Amsterdam, The Netherlands
    Cell 138:935-46. 2009
    ....
  13. ncbi Synaptotagmins I and II act as nerve cell receptors for botulinum neurotoxin G
    Andreas Rummel
    Institutes of Biochemistry and Toxicology, Medizinische Hochschule Hannover, D 30625 Hannover, Germany
    J Biol Chem 279:30865-70. 2004
    ..In addition, we show that the carboxyl-terminal domain of the cell binding fragment of BoNT/B and BoNT/G mediates the interaction with their protein receptor...
  14. ncbi Synaptotagmin I synchronizes transmitter release in mouse hippocampal neurons
    Tei ichi Nishiki
    Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Neurosci 24:6127-32. 2004
    ..Thus, synaptotagmin I synchronizes the rapid release of neurotransmitters after Ca2+ entry into presynaptic terminals and also appears to suppress the slower, asynchronous form of transmitter release...
  15. ncbi Dual roles of the C2B domain of synaptotagmin I in synchronizing Ca2+-dependent neurotransmitter release
    Tei ichi Nishiki
    Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Neurosci 24:8542-50. 2004
    ....
  16. pmc Kinetic efficiency of endocytosis at mammalian CNS synapses requires synaptotagmin I
    Karin Nicholson-Tomishima
    Department of Biochemistry, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 101:16648-52. 2004
    ..basis of this coupling is poorly understood, numerous biochemical data point to a role for synaptotagmin I (SytI), an essential synaptic vesicle protein required for fast calcium-dependent exocytosis...
  17. pmc Conformational switch of syntaxin-1 controls synaptic vesicle fusion
    Stefan H Gerber
    Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390 9111, USA
    Science 321:1507-10. 2008
    ..Thus, the closed conformation of syntaxin-1 gates the initiation of the synaptic vesicle fusion reaction, which is then mediated by SNARE-complex/Munc18-1 assemblies...
  18. doi SNARE protein recycling by αSNAP and βSNAP supports synaptic vesicle priming
    Andrea Burgalossi
    Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, D 37075 Gottingen, Germany
    Neuron 68:473-87. 2010
    ..Our analysis of α- and βSNAP deletion mutant neurons shows that the two NSF cofactors support synaptic vesicle priming by determining the availability of free SNARE components, particularly during phases of high synaptic activity...
  19. pmc Synaptotagmin-1 and -7 are functionally overlapping Ca2+ sensors for exocytosis in adrenal chromaffin cells
    Jean Sébastien Schonn
    Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, D 37077 Gottingen, Germany
    Proc Natl Acad Sci U S A 105:3998-4003. 2008
    ....
  20. ncbi Synaptotagmin-1, -2, and -9: Ca(2+) sensors for fast release that specify distinct presynaptic properties in subsets of neurons
    Jun Xu
    Department of Neuroscience, The University of Texas Southwestern Medical Center, Dallas TX 75390, USA
    Neuron 54:567-81. 2007
    ....
  21. ncbi Synaptotagmin I and II are present in distinct subsets of central synapses
    Michael A Fox
    Department of Molecular and Cellular Biology and Center for Brain Science, Harvard University, Cambridge, Massachusetts 02138, USA
    J Comp Neurol 503:280-96. 2007
    b>Synaptotagmin 1 and 2 (syt 1, syt 2) are synaptic vesicle-associated membrane proteins that act as calcium sensors for fast neurotransmitter release from presynaptic nerve terminals...
  22. pmc v-SNAREs control exocytosis of vesicles from priming to fusion
    Maria Borisovska
    Department of Physiology, University of Saarland, Homburg Saar, Germany
    EMBO J 24:2114-26. 2005
    ..We demonstrate that dynamics of fusion pore dilation are regulated by v-SNAREs, indicating their action throughout exocytosis from priming to fusion of vesicles...
  23. pmc Synaptotagmin isoforms couple distinct ranges of Ca2+, Ba2+, and Sr2+ concentration to SNARE-mediated membrane fusion
    Akhil Bhalla
    Department of Physiology, University of Wisconsin, Madison, WI 53706, USA
    Mol Biol Cell 16:4755-64. 2005
    ..Our data demonstrate that different syt isoforms are specialized to sense different ranges of divalent cations and that PS is an essential effector of Ca2+.syt action...
  24. ncbi Autonomous function of synaptotagmin 1 in triggering synchronous release independent of asynchronous release
    Anton Maximov
    Center for Basic Neuroscience, Department of Molecular Genetics, and Howard Hughes Medical Institute, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Neuron 48:547-54. 2005
    ..Ca(2+) triggers neurotransmitter release in at least two principal modes, synchronous and asynchronous release. Synaptotagmin 1 functions as a Ca(2+) sensor for synchronous release, but its role in asynchronous release remains unclear...
  25. pmc Augmenting neurotransmitter release by enhancing the apparent Ca2+ affinity of synaptotagmin 1
    J S Rhee
    Department of Neuroscience, Baylor College of Medicine, One Baylor Plaza, Houston, TX 7703, USA
    Proc Natl Acad Sci U S A 102:18664-9. 2005
    b>Synaptotagmin 1 likely acts as a Ca2+ sensor in neurotransmitter release by Ca2+-binding to its two C2 domains...
  26. ncbi Phosphatidylinositol phosphates as co-activators of Ca2+ binding to C2 domains of synaptotagmin 1
    LiYi Li
    Department of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 281:15845-52. 2006
    Ca2+-dependent phospholipid binding to the C2A and C2B domains of synaptotagmin 1 is thought to trigger fast neurotransmitter release, but only Ca2+ binding to the C2B domain is essential for release...
  27. ncbi A gain-of-function mutation in synaptotagmin-1 reveals a critical role of Ca2+-dependent soluble N-ethylmaleimide-sensitive factor attachment protein receptor complex binding in synaptic exocytosis
    Zhiping P Pang
    Center for Basic Neuroscience, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Neurosci 26:12556-65. 2006
    ..These data establish that fast vesicle exocytosis is driven by a dual Ca2+-dependent activity of synaptotagmin-1, namely Ca2+-dependent binding both to SNARE complexes and to phospholipids...
  28. ncbi A complexin/synaptotagmin 1 switch controls fast synaptic vesicle exocytosis
    Jiong Tang
    The Center for Basic Neuroscience, UT Southwestern Medical Center, Dallas, TX 75390, USA
    Cell 126:1175-87. 2006
    Ca(2+) binding to synaptotagmin 1 triggers fast exocytosis of synaptic vesicles that have been primed for release by SNARE-complex assembly. Besides synaptotagmin 1, fast Ca(2+)-triggered exocytosis requires complexins...
  29. pmc Complexin clamps asynchronous release by blocking a secondary Ca(2+) sensor via its accessory α helix
    Xiaofei Yang
    Department of Molecular and Cellular Physiology, Stanford University, 1050 Arastradero Road, Palo Alto, CA 94304 5543, USA
    Neuron 68:907-20. 2010
    ..Thus, complexin performs mechanistically distinct activation and clamping functions that operate in conjunction with synaptotagmin-1 by controlling trans-SNARE-complex assembly...
  30. ncbi Ca(2+)-dependent and -independent activities of neural and non-neural synaptotagmins
    C Li
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas 75235, USA
    Nature 375:594-9. 1995
    ..The same C2 domains also bind syntaxin as a function of Ca2+ but the Ca(2+)-concentration dependence of Syt I, II and V (> 200 microM) differs from that of Syt III and VII (< 10 microM).(ABSTRACT TRUNCATED AT 250 WORDS)..
  31. ncbi Synaptotagmin I: a major Ca2+ sensor for transmitter release at a central synapse
    M Geppert
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas 75235
    Cell 79:717-27. 1994
    ..We propose that synaptotagmin I is the major low affinity Ca2+ sensor mediating Ca2+ regulation of synchronous neurotransmitter release in hippocampal neurons...
  32. pmc Complexin activates exocytosis of distinct secretory vesicles controlled by different synaptotagmins
    Peng Cao
    Department of Molecular and Cellular Physiology and Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, California 94305 5543, USA
    J Neurosci 33:1714-27. 2013
    ....
  33. pmc Glycosylation is dispensable for sorting of synaptotagmin 1 but is critical for targeting of SV2 and synaptophysin to recycling synaptic vesicles
    Sung E Kwon
    Howard Hughes Medical Institute, Department of Neuroscience, University of Wisconsin, Madison, Wisconsin 53706, USA
    J Biol Chem 287:35658-68. 2012
    ..For example, the three major synaptic vesicle glycoproteins, synaptotagmin 1, synaptophysin, and SV2, represent ∼30% of the total copy number of vesicle proteins...
  34. pmc Uncoupling the roles of synaptotagmin I during endo- and exocytosis of synaptic vesicles
    Jun Yao
    Howard Hughes Medical Institute and Department of Neuroscience, University of Wisconsin, Madison, Wisconsin, USA
    Nat Neurosci 15:243-9. 2011
    Synaptotagmin I (syt1) is required for normal rates of synaptic vesicle endo- and exocytosis...
  35. ncbi Synaptotagmin I functions as a calcium regulator of release probability
    R Fernandez-Chacon
    Center for Basic Neuroscience, Department of Molecular Genetics, and Howard Hughes Medical Institute, The University of Texas Southwestern Medical Center, Dallas 75390 9111, USA
    Nature 410:41-9. 2001
    ..Therefore, Ca2+ binding to synaptotagmin I participates in triggering neurotransmitter release at the synapse...
  36. pmc Intracellular calcium dependence of large dense-core vesicle exocytosis in the absence of synaptotagmin I
    T Voets
    Department of Membrane Biophysics, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37077 Gottingen, Germany
    Proc Natl Acad Sci U S A 98:11680-5. 2001
    ..Alternatively, synaptotagmin I could function as calcium sensor for the readily releasable pool, leading to the destabilization of the pool in its absence...
  37. ncbi Genetic ablation of the t-SNARE SNAP-25 distinguishes mechanisms of neuroexocytosis
    Philip Washbourne
    Department of Neurosciences, University of New Mexico Health Science Center, Albuquerque, New Mexico 87131, USA
    Nat Neurosci 5:19-26. 2002
    ..These results demonstrate that the development of neurotransmission requires the recruitment of a specialized SNARE core complex to meet the demands of regulated exocytosis...
  38. pmc Doc2 is a Ca2+ sensor required for asynchronous neurotransmitter release
    Jun Yao
    Howard Hughes Medical Institute and Department of Neuroscience, University of Wisconsin, Madison, WI 53706, USA
    Cell 147:666-77. 2011
    ..In summary, we propose that Doc2 is a Ca(2+) sensor that is kinetically tuned to regulate asynchronous neurotransmitter release...
  39. ncbi Sr2+ binding to the Ca2+ binding site of the synaptotagmin 1 C2B domain triggers fast exocytosis without stimulating SNARE interactions
    Ok Ho Shin
    Center for Basic Neuroscience, Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Neuron 37:99-108. 2003
    Sr(2+) triggers neurotransmitter release similar to Ca(2+), but less efficiently. We now show that in synaptotagmin 1 knockout mice, the fast component of both Ca(2+)- and Sr(2+)-induced release is selectively impaired, suggesting that ..
  40. pmc Synaptotagmins I and II mediate entry of botulinum neurotoxin B into cells
    Min Dong
    Department of Physiology, University of Wisconsin, Madison, Madison, WI 53706, USA
    J Cell Biol 162:1293-303. 2003
    ..Finally, we show that syt II fragments, in conjunction with gangliosides, neutralized BoNT/B in intact mice. These findings establish that syts I and II can function as protein receptors for BoNT/B...
  41. ncbi Structure/function analysis of Ca2+ binding to the C2A domain of synaptotagmin 1
    Rafael Fernandez-Chacon
    Center for Basic Neuroscience, Department of Molecular Genetics, and Howard Hughes Medical Institute, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9111, USA
    J Neurosci 22:8438-46. 2002
    b>Synaptotagmin 1, a Ca2+ sensor for fast synaptic vesicle exocytosis, contains two C2 domains that form Ca2+-dependent complexes with phospholipids...
  42. ncbi SNAP-25 and synaptotagmin 1 function in Ca2+-dependent reversible docking of granules to the plasma membrane
    Evelina Chieregatti
    Department of Anatomy and Cell Biology, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
    Traffic 3:496-511. 2002
    ..In the docking assay, addition of Ca2+ induces the formation of a SNAP-25-Synaptotagmin 1 complex...
  43. pmc Examining synaptotagmin 1 function in dense core vesicle exocytosis under direct control of Ca2+
    Jakob B Sørensen
    Max Planck Institut fur biophysikalische Chemie, Abteilung Membranbiophysik, Am Fassberg 11, D 37077 Gottingen, Germany
    J Gen Physiol 122:265-76. 2003
    We tested the long-standing hypothesis that synaptotagmin 1 is the Ca2+ sensor for fast neurosecretion by analyzing the intracellular Ca2+ dependence of large dense-core vesicle exocytosis in a mouse strain carrying a mutated ..
  44. ncbi Different effects on fast exocytosis induced by synaptotagmin 1 and 2 isoforms and abundance but not by phosphorylation
    Gabor Nagy
    Max Planck Institute for Biophysical Chemistry, D 37077 Gottingen, Germany
    J Neurosci 26:632-43. 2006
    Synaptotagmins comprise a large protein family, of which synaptotagmin 1 (Syt1) is a Ca2+ sensor for fast exocytosis, and its close relative, synaptotagmin 2 (Syt2), is assumed to serve similar functions...
  45. ncbi The alternative translation of synaptotagmin 1 mediates the non-classical release of FGF1
    C Bagala
    Center for Molecular Medicine, Maine Medical Center Research Institute, Scarborough, ME 04074, USA
    Biochem Biophys Res Commun 310:1041-7. 2003
    ..FGF1, it was not possible to identify a specific intracellular protease responsible for the processing of p65 Syt1. Surprisingly, analysis of the p65 Syt1 coding sequence revealed the presence of two potential alternative ATG ..
  46. pmc Somatodendritic dopamine release requires synaptotagmin 4 and 7 and the participation of voltage-gated calcium channels
    Jose Alfredo Mendez
    Department of Pharmacology, Groupe de Recherche sur le Système Nerveux Central, Faculty of Medicine, Universite de Montreal, Montreal, Quebec H3C 3J7, Canada
    J Biol Chem 286:23928-37. 2011
    ..of the dendritically expressed Syt4 and Syt7 severely reduced STD DA release, whereas terminal release required Syt1. Moreover, we found that although mobilization of intracellular Ca(2+) stores is inefficient, Ca(2+) influx through ..
  47. pmc Probing the functional equivalence of otoferlin and synaptotagmin 1 in exocytosis
    Ellen Reisinger
    Molecular Biology of Cochlear Neurotransmission, Department of Otolaryngology, University Medical Center Gottingen, 37099 Gottingen, Germany
    J Neurosci 31:4886-95. 2011
    ..serve as a Ca(2+) sensor in vesicle fusion in IHCs that seem to lack the classical neuronal Ca(2+) sensors synaptotagmin 1 (Syt1) and Syt2...
  48. doi Human SCAMP5, a novel secretory carrier membrane protein, facilitates calcium-triggered cytokine secretion by interaction with SNARE machinery
    Chaofeng Han
    Institute of Immunology, Tsinghua University School of Medicine, Beijing, People s Republic of China
    J Immunol 182:2986-96. 2009
    ..Our findings suggest that hSCAMP5, in cooperation with the SNARE machinery, is involved in calcium-regulated exocytosis of signal peptide-containing cytokines...
  49. pmc SNAREpin assembly by Munc18-1 requires previous vesicle docking by synaptotagmin 1
    Daniel Parisotto
    Heidelberg University Biochemistry Center, Im Neuenheimer Feld 328, 69120 Heidelberg, Germany
    J Biol Chem 287:31041-9. 2012
    ..docking, priming, and fusion of small unilamellar vesicles containing the v-SNARE VAMP2 and the Ca(2+) sensor synaptotagmin 1. In vitro assays allowed us to position Munc18-1 in the center of a sequential reaction cascade; vesicle ..
  50. pmc Synaptotagmin-1 functions as a Ca2+ sensor for spontaneous release
    Jun Xu
    Department of Molecular and Cellular Physiology, Stanford University, Palo Alto, California, USA
    Nat Neurosci 12:759-66. 2009
    ..that >95% of spontaneous release in murine cortical neurons was induced by Ca2+-binding to synaptotagmin-1 (Syt1), the Ca2+ sensor for fast synchronous neurotransmitter release...
  51. pmc Synaptic protein and pan-neuronal gene expression and their regulation by Dicer-dependent mechanisms differ between neurons and neuroendocrine cells
    Jutta Stubbusch
    Max Planck Institute for Brain Research, Deutschordenstrasse 46 D 60528, Frankfurt, Germany
    Neural Dev 8:16. 2013
    ....
  52. pmc Synaptotagmin-1 and synaptotagmin-7 trigger synchronous and asynchronous phases of neurotransmitter release
    Taulant Bacaj
    Department of Molecular and Cellular Physiology and Howard Hughes Medical Institute, Stanford University Medical School, Stanford, CA 94305, USA
    Neuron 80:947-59. 2013
    ....
  53. pmc Phosphorylation of synaptic vesicle protein 2A at Thr84 by casein kinase 1 family kinases controls the specific retrieval of synaptotagmin-1
    Ning Zhang
    Medical Research Council Protein Phosphorylation and Ubiquitylation Unit, College of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, United Kingdom, and
    J Neurosci 35:2492-507. 2015
    ....
  54. pmc Phosphorylation of synaptotagmin-1 controls a post-priming step in PKC-dependent presynaptic plasticity
    Arthur P H de Jong
    Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, VU University and VU Medical Center, Amsterdam 1081HV, The Netherlands
    Proc Natl Acad Sci U S A 113:5095-100. 2016
    ..Here, we show that a mutation in synaptotagmin-1 (Syt1(T112A)), which prevents its PKC-dependent phosphorylation, abolishes DAG-induced potentiation of synaptic ..
  55. pmc Architecture of the synaptotagmin-SNARE machinery for neuronal exocytosis
    Qiangjun Zhou
    Department of Molecular and Cellular Physiology, Howard Hughes Medical Institute, Stanford University, Stanford, California 94305, USA
    Nature 525:62-7. 2015
    ....
  56. pmc Identification of the novel activity-driven interaction between synaptotagmin 1 and presenilin 1 links calcium, synapse, and amyloid beta
    Akira Kuzuya
    MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, USA
    BMC Biol 14:25. 2016
    ....
  57. ncbi The secretory granule-associated protein CAPS2 regulates neurotrophin release and cell survival
    Tetsushi Sadakata
    Laboratory for Molecular Neurogenesis, RIKEN Brain Science Institute, Wako, Saitama 351 0198, Japan
    J Neurosci 24:43-52. 2004
    ..Thus, we suggest that CAPS2 mediates the depolarization-dependent release of NT-3 and BDNF from granule cells, leading to regulation in cell differentiation and survival during cerebellar development...
  58. ncbi Scrg1, a novel protein of the CNS is targeted to the large dense-core vesicles in neuronal cells
    Françoise Dandoy-Dron
    Laboratoire d Oncologie virale, CNRS UPR 9045, 7 rue G Môquet BP 8, 94801 Villejuif Cedex, France
    Eur J Neurosci 18:2449-59. 2003
    ..Our findings strongly suggest that Scrg1 is associated with the secretory pathway of neuronal cells...
  59. doi Synaptotagmin 1 is necessary for the Ca2+ dependence of clathrin-mediated endocytosis
    Li Hua Yao
    Department of Biological Sciences, University of Illinois at Chicago, Chicago, Illinois 60607, USA
    J Neurosci 32:3778-85. 2012
    ..that the dynamics of vesicle fission during CME is Ca²⁺ dependent but becomes Ca²⁺ independent in synaptotagmin 1 (Syt1) knock-out cells. Our results thus suggest that Syt1 is necessary for the Ca²⁺ dependence of CME.
  60. doi Synaptotagmin1 is required for spindle stability and metaphase-to-anaphase transition in mouse oocytes
    Xiu Lan Zhu
    Center for Reproductive Medicine, Department of Ob Gy, Nanfang Hospital, Southern Medical University, Guangzhou City, Guangdong Province, China
    Cell Cycle 11:818-26. 2012
    ..Here, we identified the unique localization, expression and function of Syt1 during mouse oocyte meiotic maturation by using confocal microscopy, western blotting, Morpholino-based knockdown ..
  61. pmc Reconstituted synaptotagmin I mediates vesicle docking, priming, and fusion
    Zhao Wang
    Department of Neuroscience, Howard Hughes Medical Institute, University of Wisconsin, Madison, WI 53706, USA
    J Cell Biol 195:1159-70. 2011
    ..Together, these findings reveal further convergence of reconstituted and cell-based systems...
  62. doi DJ-1 associates with synaptic membranes
    Yukiko Usami
    Department of Neurology, Juntendo University School of Medicine, Japan
    Neurobiol Dis 43:651-62. 2011
    ..These results indicate that DJ-1 associates with membranous organelles including synaptic membranes to exhibit its normal function...
  63. pmc Crystal structure of the botulinum neurotoxin type G binding domain: insight into cell surface binding
    Pal Stenmark
    Department of Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Mol Biol 397:1287-97. 2010
    ..While BoNT/G and BoNT/B are homologous to each other and both utilize Syt-I/Syt-II as their protein receptor, the precise means by which these two toxin serotypes bind to Syt appears surprisingly divergent...
  64. ncbi Synaptotagmin 3 deficiency in T cells impairs recycling of the chemokine receptor CXCR4 and thereby inhibits CXCL12 chemokine-induced migration
    Agnieszka Masztalerz
    Division of Cell Biology, The Netherlands Cancer Institute, 121 Plesmanlaan, 1066CX Amsterdam, The Netherlands
    J Cell Sci 120:219-28. 2007
    ..Migration was restored by overexpression of CXCR4. We conclude that STT3 is essential for CXCR4 recycling in T cells and thereby for the maintenance of high CXCR4 surface levels required for migration...
  65. pmc RIM1alpha and interacting proteins involved in presynaptic plasticity mediate prepulse inhibition and additional behaviors linked to schizophrenia
    Jacqueline Blundell
    Departments of Neurology and Psychiatry, The University of Texas Southwestern Medical Center, Dallas, Texas, 75390 8813, USA
    J Neurosci 30:5326-33. 2010
    ..selective to RIM1alpha-deficient mice, as mice bearing mutations in the RIM1alpha binding partners Rab3A or synaptotagmin 1 only show decreased prepulse inhibition...
  66. pmc Cotrafficking of SV2 and synaptotagmin at the synapse
    Jia Yao
    Department of Pharmacology, University of Washington, Seattle, Washington 98195, USA
    J Neurosci 30:5569-78. 2010
    ....
  67. pmc Structural and mutational analysis of functional differentiation between synaptotagmins-1 and -7
    Mingshan Xue
    Department of Neuroscience, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS ONE 5:. 2010
    ..chimera that contains the synaptotagmin-1 sequence with its C2B domain replaced by the synaptotagmin-7 C2B domain (Syt1/7)...
  68. pmc Control of exocytosis by synaptotagmins and otoferlin in auditory hair cells
    Maryline Beurg
    Equipe Neurophysiologie de la Synapse Auditive, Institut National de la Sante et de la Recherche Medicale, Unité Mixte de Récherche Scientifique 587, Université Victor Segalen and Institut des Neurosciences de Bordeaux, Centre Hospitalier Universitaire Pellegrin, 33076 Bordeaux, France
    J Neurosci 30:13281-90. 2010
    ..During this early exocytotic period, several synaptotagmins (Syts), including Syt1, Syt2 and Syt7, were detected in IHCs...
  69. doi Synaptotagmin1 synthesis induced by synaptic plasticity in mouse hippocampus through activation of nicotinic acetylcholine receptors
    Takaaki Nishimoto
    Department of Pharmaceutical Health Care, Faculty of Pharmaceutical Sciences, Himeji Dokkyo University, 7 2 1 Kamiohno, Himeji 670 8524, Japan
    Neurosci Lett 489:25-9. 2011
    ..These results suggest that new-synthesized synaptotagmin1 following synaptic plasticity may contribute to long-lasting synaptic plasticity via positive, feedfoward mechanisms...
  70. ncbi TrkB and TrkC signaling are required for maturation and synaptogenesis of hippocampal connections
    A Martinez
    Department of Animal and Plant Cell Biology, University of Barcelona, Barcelona 08028, Spain
    J Neurosci 18:7336-50. 1998
    ..The data also suggest that the genes encoding for synaptic proteins may be targets of TrkB and TrkC signaling pathways...
  71. ncbi Synaptotagmins: C2-domain proteins that regulate membrane traffic
    T C Sudhof
    Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas 75235, USA
    Neuron 17:379-88. 1996
  72. ncbi Genetic mapping of five mouse genes encoding synaptotagmins
    O J Kwon
    Laboratory of Neurochemistry, NINDS, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mamm Genome 6:880-1. 1995
  73. ncbi Synaptobrevin is essential for secretion but not for the development of synaptic processes
    G Ahnert-Hilger
    Medizinische Klinik und Poliklinik, Abt Gastroenterologie, Universitatsklinikum Benjamin Franklin, Freie Universitat Berlin, Germany
    Eur J Cell Biol 70:1-11. 1996
    ..We conclude that synaptobrevin represents a marker for early events in synaptogenesis. Its proteolysis by tetanus toxin, however, does not interfere with the formation of synaptic contacts and neuronal differentiation...
  74. ncbi Synaptotagmin genes on mouse chromosomes 1, 7, and 10 and human chromosome 19
    J M Jones
    Department of Human Genetics, University of Michigan, Ann Arbor 48109 0618, USA
    Mamm Genome 6:212-3. 1995
  75. ncbi Insertional mutation of the motor endplate disease (med) locus on mouse chromosome 15
    D C Kohrman
    Department of Human Genetics, University of Michigan, Ann Arbor 48109 0618, USA
    Genomics 26:171-7. 1995
    ..The homologous human locus MED was assigned to chromosome 12. Synaptotagmin 1 and contactin 1 were eliminated as candidate genes for the med mutation...
  76. pmc Cyclic AMP-mediated endocytosis of intestinal epithelial NHE3 requires binding to synaptotagmin 1
    Mark W Musch
    Martin Boyer Laboratories, Department of Medicine, University of Chicago, 5841 S Maryland Ave, Chicago, IL 60637, USA
    Am J Physiol Gastrointest Liver Physiol 298:G203-11. 2010
    ..The clathrin complex adaptor protein synaptotagmin 1 (Syt 1) appears to be essential to this process, but little is known about its expression in intestinal ..
  77. ncbi Synaptotagmin VI and VIII and syntaxin 2 are essential for the mouse sperm acrosome reaction
    Darren M Hutt
    Ottawa Health Research Institute, Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario K1Y 4E9, Canada
    J Biol Chem 280:20197-203. 2005
    ..Taken together, our data suggest a critical role for Syt VIII and Stx2 in membrane fusion and acrosome reaction in the sperm...
  78. doi Upregulation of hippocampal TrkB and synaptotagmin is involved in treadmill exercise-enhanced aversive memory in mice
    Yu Fan Liu
    Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan
    Neurobiol Learn Mem 90:81-9. 2008
    ..Taken together, these data suggest that the upregulation of TrkB and synaptotagmin in the hippocampus contributes to the exercise-facilitated aversive memory...
  79. doi Synaptotagmin IV regulates dense core vesicle (DCV) release in LbetaT2 cells
    Zhi Tao Hu
    Key Laboratory of Molecular Biophysics, Ministry of Education, and Joint Laboratory of Institute of Biophysics and Huazhong University of Science and Technology, Huazhong University of Science and Technology, Luoyu Road 1037, Wuhan 430074, PR China
    Biochem Biophys Res Commun 371:781-6. 2008
    ..Downregulation of Syt IV clearly reduced Ca(2+)-triggered exocytosis of dense core vesicles (DCVs) in LbetaT2 cells. Syt I silencing, however, had no effect on vesicular release...
  80. ncbi Breakdown of axonal synaptic vesicle precursor transport by microglial nitric oxide
    Massimiliano Stagi
    Neuroimmunology Group, European Neuroscience Institute Göttingen, 37073 Gottingen, Germany
    J Neurosci 25:352-62. 2005
    ..Thus, overt production of reactive NO by activated microglia blocks the axonal transport of synaptic vesicle precursors via phosphorylation of JNK and could cause axonal and synaptic dysfunction...
  81. pmc Mechanism of botulinum neurotoxin B and G entry into hippocampal neurons
    Min Dong
    Howard Hughes Medical Institute, Department of Physiology, University of Wisconsin, Madison, WI 53706, USA
    J Cell Biol 179:1511-22. 2007
    ..These data suggest that gangliosides are the shared coreceptor for BoNT/A, B, and G, supporting a double-receptor model for these three BoNTs for which the protein receptors are known...
  82. ncbi WNK1 phosphorylates synaptotagmin 2 and modulates its membrane binding
    Byung Hoon Lee
    Department of Pharmacology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Mol Cell 15:741-51. 2004
    ..These findings provide a biochemical mechanism that could lead to the retention or insertion of proteins in the plasma membrane. Interruption of this regulatory pathway may disturb membrane events that regulate ion balance...
  83. pmc Role of topoisomerase IIbeta in the expression of developmentally regulated genes
    Yi Lisa Lyu
    Department of Pharmacology, UMDNJ Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA
    Mol Cell Biol 26:7929-41. 2006
    ..Together, these results support a role of TopIIbeta in activation/repression of developmentally regulated genes at late stages of neuronal differentiation...
  84. pmc Normal development and fertility of knockout mice lacking the tumor suppressor gene LRP1b suggest functional compensation by LRP1
    Peter Marschang
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Mol Cell Biol 24:3782-93. 2004
    ..Analysis of LRP1b knockout mice may provide further insights into the role of LRP1b as a tumor suppressor and into the mechanisms of cancer development...
  85. pmc Differential effects of treadmill running and wheel running on spatial or aversive learning and memory: roles of amygdalar brain-derived neurotrophic factor and synaptotagmin I
    Yu Fan Liu
    Institute of Basic Medical Sciences, Department of Physiology, National Cheng Kung University, Tainan, Taiwan
    J Physiol 587:3221-31. 2009
    ..Therefore, our results support the notion that different forms of exercise induce neuroplasticity changes in different brain regions, and thus exert diverse effects on various forms of learning and memory...
  86. doi Involvement of Ca2+ channel synprint site in synaptic vesicle endocytosis
    Hiroyasu Watanabe
    Cellular and Molecular Synaptic Function Unit, Initial Research Project, Okinawa Institute of Science and Technology Promotion Corporation, Okinawa 904 2234, Japan
    J Neurosci 30:655-60. 2010
    ..bind the mu subunit of AP-2, an adaptor protein for clathrin-mediated endocytosis, in competition with the synaptotagmin 1 (Syt 1) C2B domain...
  87. pmc The presynaptic active zone protein RIM1alpha is critical for normal learning and memory
    Craig M Powell
    Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Neuron 42:143-53. 2004
    ..Mice with a synaptotagmin 1 mutation, which selectively lowers release probability, and mice with Rab3A deletion, which selectively ..
  88. ncbi Synaptotagmin mutants Y311N and K326/327A alter the calcium dependence of neurotransmission
    Catherine R Borden
    Molecular Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Mol Cell Neurosci 29:462-70. 2005
    ..We conclude that self-oligomerization is unlikely to play any significant role in triggering synaptic vesicle exocytosis...
  89. pmc A third synaptotagmin gene, Syt3, in the mouse
    B S Hilbush
    Roche Institute of Molecular Biology, Roche Research Center, Nutley, NJ 07110
    Proc Natl Acad Sci U S A 91:8195-9. 1994
    ..In the most highly conserved C2 domain, the mammalian synaptotagmins, SYT1 and SYT2, share 88% sequence identity, whereas SYT3 has only approximately 45% identity to either...
  90. ncbi Defective neuromuscular synaptogenesis in agrin-deficient mutant mice
    M Gautam
    Department of Anatomy and Neurobiology, Washington University Medical School St Louis, Missouri 63110, USA
    Cell 85:525-35. 1996
    ....
  91. ncbi CAPS1 regulates catecholamine loading of large dense-core vesicles
    Dina Speidel
    Max Planck Institut fur experimentelle Medizin, Abteilung Molekulare Neurobiologie, D 37075 Gottingen, Germany
    Neuron 46:75-88. 2005
    ..We conclude that CAPS1 is required for an essential step in the uptake or storage of catecholamines in LDCVs...
  92. ncbi Complexins: cytosolic proteins that regulate SNAP receptor function
    H T McMahon
    Howard Hughes Medical Institute, University of Texas Southwestern Medical School, Dallas 75235, USA
    Cell 83:111-9. 1995
    ....
  93. ncbi Synapsin and synaptic vesicle protein expression during embryonic and post-natal lens fiber cell differentiation
    Peter H Frederikse
    Department of Pharmacology and Physiology, UMDNJ New Jersey Medical School, Newark, NJ 07103, USA
    Mol Vis 10:794-804. 2004
    ..In the present study we examine lens expression and regulation of a complement of genes associated with cargo and synaptic vesicle transport in neurons...
  94. ncbi Botulinum neurotoxin A activity is dependent upon the presence of specific gangliosides in neuroblastoma cells expressing synaptotagmin I
    Brian C Yowler
    Department of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    J Biol Chem 277:32815-9. 2002
    ....
  95. pmc Calmodulin and lipid binding to synaptobrevin regulates calcium-dependent exocytosis
    Stephanie Quetglas
    Institut National de la Santé et de la Recherche Médicale Unité 464, Universite de la Mediterranee, 13916 Marseille Cedex 20, France
    EMBO J 21:3970-9. 2002
    ..The calmodulin- and phospholipid-binding domain of VAMP 2 is thus required for Ca(2+)-dependent exocytosis, possibly to regulate SNARE complex assembly...
  96. ncbi Molecular cloning, expression, and characterization of a novel class of synaptotagmin (Syt XIV) conserved from Drosophila to humans
    Mitsunori Fukuda
    Fukuda Initiative Research Unit, RIKEN The Institute of Physical and Chemical Research, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    J Biochem 133:641-9. 2003
    ....
  97. ncbi Molecular determinants of synapsin targeting to presynaptic terminals
    Daniel Gitler
    Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Neurosci 24:3711-20. 2004
    ..Domain D inhibited targeting, but this inhibition was overcome by domain E. Thus, multiple intermolecular and intramolecular interactions are required for synapsins to target to presynaptic terminals...
  98. pmc Morphogenesis of the telencephalic commissure requires scaffold protein JNK-interacting protein 3 (JIP3)
    Nyaya Kelkar
    Howard Hughes Medical Institute and Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Worcester, MA 01605, USA
    Proc Natl Acad Sci U S A 100:9843-8. 2003
    ..The central nervous system abnormalities of Jip3-/- mice may be accounted for in part by a reduction in signal transduction by RhoA and its effector ROCK...
  99. pmc Synaptotagmin IV regulates glial glutamate release
    Qi Zhang
    Department of Neuroscience, Room 215, Stemmler Hall, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 101:9441-6. 2004
    ....
  100. ncbi Quantification of synapse formation and maintenance in vivo in the absence of synaptic release
    J Bouwman
    Rudolf Magnus Institute for Neurosciences, University of Utrecht Medical Center, Utrecht, The Netherlands
    Neuroscience 126:115-26. 2004
    ..These two observations suggest that secretion of neurotransmitters and neuromodulatory substances is required for synapse maintenance, not for synaptogenesis. Multivesicular structures may develop out of unstable synapses...

Research Grants3

  1. ALZHEIMER PATHOPHYSIOLOGY IN HUMAN CATARACT FORMATION
    PETER FREDERIKSE; Fiscal Year: 2002
    ..abstract_text> ..
  2. BDNF in depression, antidepressant action, and memory
    CRAIG POWELL; Fiscal Year: 2007
    ..We also propose to make use of focal injection of Cre-expressing AAV vectors into flox-BDNF mice to assess the specific brain subregions involved with greater temporal specificity. [unreadable] [unreadable]..
  3. Alzheimer disease biomarkers in lens
    Peter H Frederikse; Fiscal Year: 2010
    ..These studies build on our earlier studies to understand the role of AbetaPP and Abeta in the lens which are already providing a new and specific conceptual basis for understanding cataract and its links with the brain. ..