Swap70

Summary

Gene Symbol: Swap70
Description: SWA-70 protein
Alias: 70kDa, AV235546, switch-associated protein 70, SWAP complex protein, 70 kDa, SWAP-70
Species: mouse

Top Publications

  1. pmc Regulatory T cells sequentially migrate from inflamed tissues to draining lymph nodes to suppress the alloimmune response
    Nan Zhang
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    Immunity 30:458-69. 2009
  2. ncbi Cellular, intracellular, and developmental expression patterns of murine SWAP-70
    T Borggrefe
    Basel Institute for Immunology, Switzerland
    Eur J Immunol 29:1812-22. 1999
  3. pmc SWAP-70 regulates erythropoiesis by controlling α4 integrin
    Tatsiana Ripich
    Institute of Physiological Chemistry, Dresden University of Technology Fiedlerstr 42, Dresden, Germany
    Haematologica 96:1743-52. 2011
  4. doi Fine tuning of IRF-4 expression by SWAP-70 controls the initiation of plasma cell development
    Michael Chopin
    Institute of Physiological Chemistry, Faculty of Medicine Carl Gustav Carus, Dresden University of Technology, Dresden, Germany
    Eur J Immunol 41:3063-74. 2011
  5. doi Sphingosine 1-phosphate-induced motility and endocytosis of dendritic cells is regulated by SWAP-70 through RhoA
    Carlos Ocaña-Morgner
    Faculty of Medicine Carl Gustav Carus, Institute of Physiological Chemistry, Dresden University of Technology, D 01307 Dresden, Germany
    J Immunol 186:5345-55. 2011
  6. pmc A mutant of SWAP-70, a phosphatidylinositoltrisphosphate binding protein, transforms mouse embryo fibroblasts, which is inhibited by sanguinarine
    Yasuhisa Fukui
    Laboratory of Signal Transduction, Hoshi University, Tokyo, Japan
    PLoS ONE 5:e14180. 2010
  7. doi SYK regulates B-cell migration by phosphorylation of the F-actin interacting protein SWAP-70
    Glen Pearce
    Institute of Physiological Chemistry, Faculty of Medicine Carl Gustav Carus, Dresden University of Technology, Fiedlerstrasse 42, Dresden, Germany
    Blood 117:1574-84. 2011
  8. doi SWAP-70 controls formation of the splenic marginal zone through regulating T1B-cell differentiation
    Michael Chopin
    Institute of Physiological Chemistry, Dresden University of Technology, Dresden, Germany
    Eur J Immunol 40:3544-56. 2010
  9. doi SWAP-70 regulates RhoA/RhoB-dependent MHCII surface localization in dendritic cells
    Carlos Ocaña-Morgner
    Institute of Physiological Chemistry, Medical Faculty Carl Gustav Carus, Dresden University of Technology, Dresden, Germany
    Blood 113:1474-82. 2009
  10. doi SWAP-70 is important for invasive phenotypes of mouse embryo fibroblasts transformed by v-Src
    Avaniyapuram Kannan Murugan
    Department of Molecular Cellular Oncology and Microbiology, Tokyo Medical and Dental University, Tokyo, Japan
    IUBMB Life 60:236-40. 2008

Scientific Experts

  • Carlos Ocaña-Morgner
  • Thomas Samson
  • Yasuhisa Fukui
  • Glen Pearce
  • Rolf Jessberger
  • Michael Chopin
  • Carlos Andrés Chacón-Martínez
  • Tatsiana Ripich
  • T Borggrefe
  • Laurence Quemeneur
  • Chung Li Shu
  • Anne Götz
  • Jacqueline H Barlow
  • Tatsiana Audzevich
  • Nooshin S Bahaie
  • Annette I Garbe
  • Partha S Biswas
  • Raja Rajeswari Sivalenka
  • M Wabl
  • R Jessberger
  • Nan Zhang
  • Avaniyapuram Kannan Murugan
  • Raja R Sivalenka
  • Pia Oberbanscheidt
  • L Masat
  • Brigitte Gross
  • - Jing-Yang-Lai
  • Oscar Fernandez-Capetillo
  • Andre Nussenzweig
  • Michael Breucha
  • Rafael Casellas
  • Nadine Kiessling
  • PETER MCKINNON
  • Gamze Günal
  • Gustavo Gutierrez-Cruz
  • Hua Tang Chen
  • Chih Pin Chuu
  • Robert B Faryabi
  • Hong Wei Sun
  • Louis Staudt
  • Liang Cheng Su
  • Thomas Müller-Reichert
  • George Wright
  • Amy Malhowski
  • Nancy Wong
  • Jan Faix
  • Elsa Callen
  • Davide F Robbiani
  • Moritz Winterhoff
  • M Reza Hosseinkhani
  • Anne Roscher
  • Govind Bhagat
  • Monika Egerbacher
  • P Sriramarao
  • Anne Helen Lutter
  • Roslynn A Stirzaker
  • Ute Hempel
  • Varsha Kumar
  • Ricardo Bernhardt
  • Xiao Na Ge
  • Sanjay Gupta
  • Theresa T Lu
  • Malcolm S Blumenthal
  • Stefan Rammelt
  • Lorenz C Hofbauer
  • Bit Na Kang
  • Reinhold G Erben
  • Martin Glösmann
  • Sung Gil Ha
  • Christiane Schüler
  • Savita P Rao
  • Alessandra B Pernis
  • Bernd Schroppel
  • Yaozhong Ding
  • Girdhari Lal
  • Jordi C Ochando
  • Jonathan S Bromberg
  • Claudia Jakubzick
  • Xia Mao
  • Dan Chen
  • Na Yin
  • Veronique Angeli
  • Nobuo Tsuchida
  • Kimio Uematsu
  • Manoj Sinha
  • Sayoko Ihara
  • Emi Tokuda
  • Martin Bähler
  • Sandra Balkow
  • Stephan Grabbe

Detail Information

Publications30

  1. pmc Regulatory T cells sequentially migrate from inflamed tissues to draining lymph nodes to suppress the alloimmune response
    Nan Zhang
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    Immunity 30:458-69. 2009
    ..These results showed that sequential migration from blood to the target tissue and to dLNs is required for Treg cells to differentiate and execute fully their suppressive function...
  2. ncbi Cellular, intracellular, and developmental expression patterns of murine SWAP-70
    T Borggrefe
    Basel Institute for Immunology, Switzerland
    Eur J Immunol 29:1812-22. 1999
    ..SWAP-70 expression is not increased by gamma or UV irradiation of spleen cells, nor does it depend on p53. These characteristics are consistent with the putative role of SWAP-70 in immunoglobulin class switching...
  3. pmc SWAP-70 regulates erythropoiesis by controlling α4 integrin
    Tatsiana Ripich
    Institute of Physiological Chemistry, Dresden University of Technology Fiedlerstr 42, Dresden, Germany
    Haematologica 96:1743-52. 2011
    ..Integrin-dependent adhesion plays important roles in erythropoiesis, but how integrins are regulated during erythropoiesis remains largely unknown...
  4. doi Fine tuning of IRF-4 expression by SWAP-70 controls the initiation of plasma cell development
    Michael Chopin
    Institute of Physiological Chemistry, Faculty of Medicine Carl Gustav Carus, Dresden University of Technology, Dresden, Germany
    Eur J Immunol 41:3063-74. 2011
    ..Thus, in a dose-dependent manner, SWAP-70 controls IRF-4 protein expression and thereby regulates the initiation of PC differentiation...
  5. doi Sphingosine 1-phosphate-induced motility and endocytosis of dendritic cells is regulated by SWAP-70 through RhoA
    Carlos Ocaña-Morgner
    Faculty of Medicine Carl Gustav Carus, Institute of Physiological Chemistry, Dresden University of Technology, D 01307 Dresden, Germany
    J Immunol 186:5345-55. 2011
    ..These data demonstrate SWAP-70 as a novel regulator of S1P signaling necessary for DC motility and endocytosis...
  6. pmc A mutant of SWAP-70, a phosphatidylinositoltrisphosphate binding protein, transforms mouse embryo fibroblasts, which is inhibited by sanguinarine
    Yasuhisa Fukui
    Laboratory of Signal Transduction, Hoshi University, Tokyo, Japan
    PLoS ONE 5:e14180. 2010
    ..These results suggest that SWAP-70-374 can activate some signaling pathways, including the ERK1/2 pathway, to transform MEFs...
  7. doi SYK regulates B-cell migration by phosphorylation of the F-actin interacting protein SWAP-70
    Glen Pearce
    Institute of Physiological Chemistry, Faculty of Medicine Carl Gustav Carus, Dresden University of Technology, Fiedlerstrasse 42, Dresden, Germany
    Blood 117:1574-84. 2011
    ..These findings demonstrate a novel requirement for SYK in migration and polarization of naive recirculating B cells and show that SWAP-70 is an important target of SYK in this pathway...
  8. doi SWAP-70 controls formation of the splenic marginal zone through regulating T1B-cell differentiation
    Michael Chopin
    Institute of Physiological Chemistry, Dresden University of Technology, Dresden, Germany
    Eur J Immunol 40:3544-56. 2010
    ..The percentage of MZB in spleen of Swap70(-/-) mice was reduced to about one-third of that found in WT mice...
  9. doi SWAP-70 regulates RhoA/RhoB-dependent MHCII surface localization in dendritic cells
    Carlos Ocaña-Morgner
    Institute of Physiological Chemistry, Medical Faculty Carl Gustav Carus, Dresden University of Technology, Dresden, Germany
    Blood 113:1474-82. 2009
    ..MHCII surface localization is known to require RhoGTPases. Surprisingly, SWAP70, hitherto known to bind F-actin and Rac, also binds RhoA-GTP...
  10. doi SWAP-70 is important for invasive phenotypes of mouse embryo fibroblasts transformed by v-Src
    Avaniyapuram Kannan Murugan
    Department of Molecular Cellular Oncology and Microbiology, Tokyo Medical and Dental University, Tokyo, Japan
    IUBMB Life 60:236-40. 2008
    ..These results suggest that v-Src and SWAP-70 act synergistically in the invasion activity of MEFs...
  11. pmc SWAP-70 deficiency causes high-affinity plasma cell generation despite impaired germinal center formation
    Laurence Quemeneur
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, NY, USA
    Blood 111:2714-24. 2008
    ..Thus, SWAP-70 deficiency uncouples GC formation from T-dependent antibody and long-lived plasma cell production and causes extrafollicular generation of high-affinity plasma cells, but does not adequately support the memory response...
  12. ncbi A B-cell-specific DNA recombination complex
    T Borggrefe
    Basel Institute for Immunology, Postfach, CH 4005 Basel, Switzerland
    J Biol Chem 273:17025-35. 1998
    ..These findings are consistent with SWAP being the long elusive "switch recombinase" and with SWAP-70 being the specific recruiting element that assembles the switch recombinase from universal components...
  13. ncbi SWAP-70 associates transiently with macropinosomes
    Pia Oberbanscheidt
    Institut fur Allgemeine Zoologie und Genetik, Westfalische Wilhelms Universitat Munster, Schlossplatz 5, D 48149 Munster, Germany
    Eur J Cell Biol 86:13-24. 2007
    ..These data identify SWAP-70 as a transient component of early macropinosomes...
  14. ncbi Impaired IgE response in SWAP-70-deficient mice
    T Borggrefe
    Basel Institute for Immunology, Basel, Switzerland
    Eur J Immunol 31:2467-75. 2001
    ..LPS-induced switching to other isotypes, however, and LPS-induced proliferation were normal. We propose that SWAP-70 serves a specific role in the CD40 signaling pathway, in particular in the IgE response...
  15. ncbi Signaling protein SWAP-70 is required for efficient B cell homing to lymphoid organs
    Glen Pearce
    Institute of Physiological Chemistry, Dresden University of Technology, 01307 Dresden, Germany
    Nat Immunol 7:827-34. 2006
    ..We noted reduced migration of Swap70-/- B cells into lymph nodes in vivo...
  16. pmc SWAP-70 regulates c-kit-induced mast cell activation, cell-cell adhesion, and migration
    Raja Rajeswari Sivalenka
    Mount Sinai School of Medicine, Department of Gene and Cell Medicine, 1425 Madison Ave, Box 1496, New York, NY 10029 6574, USA
    Mol Cell Biol 24:10277-88. 2004
    ..Together, we suggest that SWAP-70 is an important regulator of specific effector pathways in c-kit signaling, including mast cell activation, migration, and cell adhesion...
  17. ncbi SWAP-70 is required for oncogenic transformation by v-Src in mouse embryo fibroblasts
    Yasuhisa Fukui
    Division of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, University of Tokyo, Bunkyo ku, Tokyo 113 8657, Japan
    Biochem Biophys Res Commun 356:512-6. 2007
    ..The v-Src-transformed MEFs deficient in SWAP-70 were unable to grow in soft agar while those expressing SWAP70 readily formed colonies, suggesting that SWAP-70 is required for anchorage independent growth of v-Src transformed ..
  18. pmc The switch-associated protein 70 (SWAP-70) bundles actin filaments and contributes to the regulation of F-actin dynamics
    Carlos Andrés Chacón-Martínez
    From the Institute of Physiological Chemistry and
    J Biol Chem 288:28687-703. 2013
    ..Together, these findings reveal an important role of SWAP-70 in the dynamic spatiotemporal regulation of F-actin networks. ..
  19. pmc Regulation of eosinophil trafficking by SWAP-70 and its role in allergic airway inflammation
    Nooshin S Bahaie
    Laboratory of Allergic Diseases and Inflammation, Department of Veterinary and Biomedical Sciences, University of Minnesota, St Paul, MN 55108, USA
    J Immunol 188:1479-90. 2012
    ..These findings suggest that regulation of eosinophil trafficking and migration by SWAP-70 is important for the development of eosinophilic inflammation after allergen exposure...
  20. pmc SWAP-70: a new type of oncogene
    Chung Li Shu
    Institute of Cellular and System Medicine, National Health Research Institutes, Zhunan Town, Miaoli County, Taiwan, Republic of China
    PLoS ONE 8:e59245. 2013
    ..Accordingly, this may explain why SWAP-70-transformed cells have different characteristics than most transformed cells...
  21. doi SWAP-70 restricts spontaneous maturation of dendritic cells
    Carlos Ocaña-Morgner
    Institute of Physiological Chemistry, Faculty of Medicine Carl Gustav Carus, Dresden University of Technology, D 01307 Dresden, Germany
    J Immunol 190:5545-58. 2013
    ..Thus, SWAP-70 deficiency reveals two pathways that contribute to spontaneous maturation of DCs...
  22. pmc Dual regulation of IRF4 function in T and B cells is required for the coordination of T-B cell interactions and the prevention of autoimmunity
    Partha S Biswas
    Autoimmunity and Inflammation Program, Hospital for Special Surgery, New York, NY 10021, USA
    J Exp Med 209:581-96. 2012
    ..Collectively, these data provide novel insights into the mechanisms that normally couple and coordinately regulate T and B cell responses to ensure tight control of productive T-B cell interactions...
  23. doi Regulation of bone mass and osteoclast function depend on the F-actin modulator SWAP-70
    Annette I Garbe
    Institute of Physiological Chemistry, Dresden University of Technology, Dresden, Germany
    J Bone Miner Res 27:2085-96. 2012
    ..The identification of the role of SWAP-70 in promoting osteoclast function through modulating membrane-proximal F-actin rearrangements reveals a new pathway to control osteoclasts and bone homeostasis...
  24. pmc Identification of early replicating fragile sites that contribute to genome instability
    Jacqueline H Barlow
    Laboratory of Genome Integrity, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
    Cell 152:620-32. 2013
    ..Moreover, greater than 50% of recurrent amplifications/deletions in human diffuse large B cell lymphoma map to ERFSs. In summary, we have identified a source of spontaneous DNA lesions that drives instability at preferred genomic sites...
  25. pmc Dendritic cell podosome dynamics does not depend on the F-actin regulator SWAP-70
    Anne Götz
    Faculty of Medicine Carl Gustav Carus, Institute of Physiological Chemistry, Dresden University of Technology, Dresden, Germany
    PLoS ONE 8:e60642. 2013
    ..Thus, podosome formation and function in dendritic cells is independent of SWAP-70...
  26. doi Control of the STAT6-BCL6 antagonism by SWAP-70 determines IgE production
    Tatsiana Audzevich
    Institute of Physiological Chemistry, Faculty of Medicine Carl Gustav Carus, Dresden University of Technology, 01307 Dresden, Germany
    J Immunol 190:4946-55. 2013
    ..We conclude that SWAP-70 controls IgE production through regulation of the antagonistic STAT6 and BCL6 occupancy of Iε. The identification of this mechanism opens new avenues to inhibit allergic reactions triggered by IgE...
  27. ncbi SWAP-70-deficient mast cells are impaired in development and IgE-mediated degranulation
    Brigitte Gross
    Basel Institute for Immunology, Basel, Switzerland
    Eur J Immunol 32:1121-8. 2002
    ..Thus, in mast cells SWAP-70 plays a role both in establishing the initial competence to degranulate and to develop into mature mast cells...
  28. ncbi Mapping of the SWAP70 gene to mouse chromosome 7 and human chromosome 11p15
    L Masat
    Department of Microbiology and Immunology, University of California, San Francisco, CA 94143 0670, USA
    Immunogenetics 51:16-9. 2000
    ....
  29. pmc SWAP-70 regulates mast cell FcepsilonRI-mediated signaling and anaphylaxis
    Raja R Sivalenka
    Department of Gene and Cell Medicine, Mount Sinai School of Medicine, New York, NY, USA
    Eur J Immunol 38:841-54. 2008
    ..We suggest that SWAP-70 defines a new element of efficient mast cell activation upon FcepsilonRI signaling, important for the control of mast cell-dependent anaphylaxis...
  30. ncbi Def-6, a guanine nucleotide exchange factor for Rac1, interacts with the skeletal muscle integrin chain alpha7A and influences myoblast differentiation
    Thomas Samson
    Department of Cell and Developmental Biology, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Biol Chem 282:15730-42. 2007
    ..Thus, our data suggest a role for Def-6 in the fine regulation of Rac1 during myogenesis with the integrin alpha7A chain guiding this regulation in a spatio-temporal manner...