Stk11

Summary

Gene Symbol: Stk11
Description: serine/threonine kinase 11
Alias: AA408040, Lkb1, Par-4, R75140, serine/threonine-protein kinase STK11, liver kinase B1 homolog, serine/threonine-protein kinase 11, serine/threonine-protein kinase LKB1, stk11
Species: mouse

Top Publications

  1. pmc A pivotal role for endogenous TGF-beta-activated kinase-1 in the LKB1/AMP-activated protein kinase energy-sensor pathway
    Min Xie
    Center for Cardiovascular Development, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 103:17378-83. 2006
  2. ncbi Mutation of Lkb1 and p53 genes exert a cooperative effect on tumorigenesis
    Chongjuan Wei
    Department of Epidemiology, The University of Texas, MD Anderson Cancer Center, Houston, 77030, USA
    Cancer Res 65:11297-303. 2005
  3. pmc Lkb1 inactivation is sufficient to drive endometrial cancers that are aggressive yet highly responsive to mTOR inhibitor monotherapy
    Cristina M Contreras
    Department of Pathology, UT Southwestern Medical Center, UT Southwestern Medical Center, Dallas, TX 75390, USA
    Dis Model Mech 3:181-93. 2010
  4. pmc Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction
    Kei Sakamoto
    MRC Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, UK
    EMBO J 24:1810-20. 2005
  5. pmc Induction of cyclooxygenase-2 in a mouse model of Peutz-Jeghers polyposis
    Derrick J Rossi
    Haartman Institute and Helsinki University Central Hospital, Biomedicum Helsinki, P O Box 63, University of Helsinki, 00014 Helsinki, Finland
    Proc Natl Acad Sci U S A 99:12327-32. 2002
  6. ncbi Adiponectin sensitizes insulin signaling by reducing p70 S6 kinase-mediated serine phosphorylation of IRS-1
    Changhua Wang
    Department of Pharmacology, University of Texas Health Science Center, San Antonio, Texas 78229, USA
    J Biol Chem 282:7991-6. 2007
  7. pmc LKB1 is required for hepatic bile acid transport and canalicular membrane integrity in mice
    Angela Woods
    Cellular Stress Group, MRC Clinical Sciences Centre, Imperial College, London, U K
    Biochem J 434:49-60. 2011
  8. ncbi LKB1 regulates neuronal migration and neuronal differentiation in the developing neocortex through centrosomal positioning
    Naoyuki Asada
    Department of Biophysics and Biochemistry, Graduate School of Science, The University of Tokyo, Bunkyo ku, Tokyo 113 0033, Japan
    J Neurosci 27:11769-75. 2007
  9. pmc LKB1 destabilizes microtubules in myoblasts and contributes to myoblast differentiation
    Isma Mian
    Center for Molecular Medicine and University of Connecticut Health Center, Farmington, Connecticut, United States of America
    PLoS ONE 7:e31583. 2012
  10. pmc Stromal liver kinase B1 [STK11] signaling loss induces oviductal adenomas and endometrial cancer by activating mammalian Target of Rapamycin Complex 1
    Pradeep S Tanwar
    Vincent Center for Reproductive Biology, Department of Obstetrics, Gynecology, and Reproductive Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America
    PLoS Genet 8:e1002906. 2012

Scientific Experts

Detail Information

Publications118 found, 100 shown here

  1. pmc A pivotal role for endogenous TGF-beta-activated kinase-1 in the LKB1/AMP-activated protein kinase energy-sensor pathway
    Min Xie
    Center for Cardiovascular Development, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 103:17378-83. 2006
    ..of the endogenous AMPK substrate acetyl CoA carboxylase, and also interfered with activation of the AMPK kinase LKB1. Thus, by disrupting the endogenous TAK1 locus, we prove a pivotal role for TAK1 in the LKB1/AMPK signaling axis, ..
  2. ncbi Mutation of Lkb1 and p53 genes exert a cooperative effect on tumorigenesis
    Chongjuan Wei
    Department of Epidemiology, The University of Texas, MD Anderson Cancer Center, Houston, 77030, USA
    Cancer Res 65:11297-303. 2005
    ..Germ line mutations in LKB1 cause PJS. We have generated mice carrying an Lkb1 exon 2 to 8 deletion by gene targeting in embryonic stem cells...
  3. pmc Lkb1 inactivation is sufficient to drive endometrial cancers that are aggressive yet highly responsive to mTOR inhibitor monotherapy
    Cristina M Contreras
    Department of Pathology, UT Southwestern Medical Center, UT Southwestern Medical Center, Dallas, TX 75390, USA
    Dis Model Mech 3:181-93. 2010
    ..We then used this tool to generate a completely penetrant Lkb1 (also known as Stk11)-based mouse model of invasive endometrial cancer...
  4. pmc Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction
    Kei Sakamoto
    MRC Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, UK
    EMBO J 24:1810-20. 2005
    Recent studies indicate that the LKB1 tumour suppressor protein kinase is the major "upstream" activator of the energy sensor AMP-activated protein kinase (AMPK)...
  5. pmc Induction of cyclooxygenase-2 in a mouse model of Peutz-Jeghers polyposis
    Derrick J Rossi
    Haartman Institute and Helsinki University Central Hospital, Biomedicum Helsinki, P O Box 63, University of Helsinki, 00014 Helsinki, Finland
    Proc Natl Acad Sci U S A 99:12327-32. 2002
    Inactivating germ-line mutations of LKB1 lead to Peutz-Jeghers syndrome (PJS). We have generated mice heterozygous for a targeted inactivating allele of Lkb1 and found that they develop severe gastrointestinal polyposis...
  6. ncbi Adiponectin sensitizes insulin signaling by reducing p70 S6 kinase-mediated serine phosphorylation of IRS-1
    Changhua Wang
    Department of Pharmacology, University of Texas Health Science Center, San Antonio, Texas 78229, USA
    J Biol Chem 282:7991-6. 2007
    ..Rapamycin, but not adiponectin, enhanced insulin-stimulated Akt phosphorylation in HeLa cells, which lack LKB1, and exogenous expression of LKB1 in HeLa cells rescued the insulin-sensitizing effect of adiponectin...
  7. pmc LKB1 is required for hepatic bile acid transport and canalicular membrane integrity in mice
    Angela Woods
    Cellular Stress Group, MRC Clinical Sciences Centre, Imperial College, London, U K
    Biochem J 434:49-60. 2011
    b>LKB1 is a 'master' protein kinase implicated in the regulation of metabolism, cell proliferation, cell polarity and tumorigenesis. However, the long-term role of LKB1 in hepatic function is unknown...
  8. ncbi LKB1 regulates neuronal migration and neuronal differentiation in the developing neocortex through centrosomal positioning
    Naoyuki Asada
    Department of Biophysics and Biochemistry, Graduate School of Science, The University of Tokyo, Bunkyo ku, Tokyo 113 0033, Japan
    J Neurosci 27:11769-75. 2007
    ..Here we find that LKB1, the closest homolog of the Caenorhabditis elegans polarity protein Par4, is expressed in the developing neocortex...
  9. pmc LKB1 destabilizes microtubules in myoblasts and contributes to myoblast differentiation
    Isma Mian
    Center for Molecular Medicine and University of Connecticut Health Center, Farmington, Connecticut, United States of America
    PLoS ONE 7:e31583. 2012
    ..We find that microtubules in differentiated myotubes are highly stabilized, but premature microtubule stabilization blocks differentiation. Factors responsible for microtubule destabilization in myoblasts have not been identified...
  10. pmc Stromal liver kinase B1 [STK11] signaling loss induces oviductal adenomas and endometrial cancer by activating mammalian Target of Rapamycin Complex 1
    Pradeep S Tanwar
    Vincent Center for Reproductive Biology, Department of Obstetrics, Gynecology, and Reproductive Biology, Massachusetts General Hospital, Boston, Massachusetts, United States of America
    PLoS Genet 8:e1002906. 2012
    Germline mutations of the Liver Kinase b1 (LKB1/STK11) tumor suppressor gene have been linked to Peutz-Jeghers Syndrome (PJS), an autosomal-dominant, cancer-prone disorder in which patients develop neoplasms in several organs, including ..
  11. pmc LKB1 deficiency sensitizes mice to carcinogen-induced tumorigenesis
    Sushma Gurumurthy
    Massachusetts General Hospital, Massachusetts General Hospital Cancer Center, Department of Medicine, Harvard Medical School, Boston, Massachusetts 02114, USA
    Cancer Res 68:55-63. 2008
    b>Lkb1 is a central regulator of cell polarity and energy metabolism through its capacity to activate the AMP-activated protein kinase (AMPK)-related family of protein kinases...
  12. doi A novel short splice variant of the tumour suppressor LKB1 is required for spermiogenesis
    Mhairi C Towler
    Division of Molecular Physiology, School of Life Sciences, University of Dundee, Dundee, Scotland, UK
    Biochem J 416:1-14. 2008
    b>LKB1 was discovered as a tumour suppressor mutated in Peutz-Jeghers syndrome, and is a gene involved in cell polarity as well as an upstream protein kinase for members of the AMP-activated protein kinase family...
  13. pmc LKB1 is essential for the proliferation of T-cell progenitors and mature peripheral T cells
    Peter Tamas
    Division of Cell Biology and Immunology, School of Life Sciences, University of Dundee, Dundee, Scotland, United Kingdom
    Eur J Immunol 40:242-53. 2010
    The serine/threonine kinase LKB1 has a conserved role in Drosophila and nematodes to co-ordinate cell metabolism...
  14. ncbi Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell vrowth
    G P Sapkota
    Medical Research Council Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland
    J Biol Chem 276:19469-82. 2001
    ..The causative gene is a protein kinase termed LKB1, predicted to function as a tumor suppressor. The mechanism by which LKB1 is regulated in cells is not known...
  15. doi Lkb1 deficiency causes prostate neoplasia in the mouse
    Helen B Pearson
    Cardiff University, School of Biosciences, Cardiff, Wales, United Kingdom
    Cancer Res 68:2223-32. 2008
    Mutation of LKB1 is the key molecular event underlying Peutz-Jeghers syndrome, a dominantly inherited condition characterized by a predisposition to a range of malignancies, including those of the reproductive system...
  16. pmc LKB1, a novel serine/threonine protein kinase and potential tumour suppressor, is phosphorylated by cAMP-dependent protein kinase (PKA) and prenylated in vivo
    S P Collins
    Department of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109, USA
    Biochem J 345:673-80. 2000
    ..The human LKB1 (hLKB1) gene encodes a serine/threonine protein kinase that is deficient in the majority of patients with PJS...
  17. ncbi Vascular abnormalities and deregulation of VEGF in Lkb1-deficient mice
    A Ylikorkala
    Molecular and Cancer Biology Program, Haartman Institute and Biomedicum Helsinki, Post Office Box 63, University of Helsinki, Helsinki 00014, Finland
    Science 293:1323-6. 2001
    The LKB1 tumor suppressor gene, mutated in Peutz-Jeghers syndrome, encodes a serine/threonine kinase of unknown function...
  18. ncbi LIP1, a cytoplasmic protein functionally linked to the Peutz-Jeghers syndrome kinase LKB1
    D P Smith
    The Breakthrough Toby Robins Breast Cancer Research Centre, London, UK
    Hum Mol Genet 10:2869-77. 2001
    b>LKB1 is a serine/threonine kinase which is inactivated by mutation in the Peutz-Jeghers polyposis and cancer predisposition syndrome (PJS). We have identified a novel leucine-rich repeat containing protein, LIP1, that interacts with LKB1...
  19. ncbi Gastrointestinal hamartomatous polyposis in Lkb1 heterozygous knockout mice
    Hiroyuki Miyoshi
    Institute of Experimental Animal Sciences, Osaka University Medical School, Osaka 565 0871, Japan
    Cancer Res 62:2261-6. 2002
    ..Germ-line mutations of the gene encoding LKB1 (STK11), a serine/threonine kinase, are identified in most PJS patients...
  20. pmc Role of Lkb1, the causative gene of Peutz-Jegher's syndrome, in embryogenesis and polyposis
    Kou ichi Jishage
    Pharmaceutical Technology Laboratory, Chugai Pharmaceutical Co, Ltd, 1 135 Komakado, Gotemba, Shizuoka 412 8513, Japan
    Proc Natl Acad Sci U S A 99:8903-8. 2002
    ..LKB1 (STK11) serine/threonine kinase is the product of the causative gene of PJS, which has been mapped to chromosome 19p13.3...
  21. ncbi Hepatocellular carcinoma caused by loss of heterozygosity in Lkb1 gene knockout mice
    Masayuki Nakau
    Department of Pharmacology, Graduate School of Medicine, Kyoto University, Kyoto 606 8501, Japan
    Cancer Res 62:4549-53. 2002
    Germline mutations of the LKB1 gene are associated with Peutz-Jeghers syndrome, which is characterized by mucocutaneous pigmentation and gastrointestinal hamartoma with an increased risk of cancer development...
  22. ncbi Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation
    Nabeel Bardeesy
    Department of Adult Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 419:162-7. 2002
    Germline mutations in LKB1 (also known as STK11) are associated with Peutz-Jeghers syndrome (PJS), a disorder with predisposition to gastrointestinal polyposis and cancer...
  23. pmc Ionizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366
    Gopal P Sapkota
    MRC Protein Phosphorylation Unit, MSI WTB complex, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, U K
    Biochem J 368:507-16. 2002
    The serine/threonine protein kinase LKB1 functions as a tumour suppressor, and mutations in this enzyme lead to the inherited Peutz-Jeghers cancer syndrome...
  24. pmc The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress
    Reuben J Shaw
    Department of Systems Biology, Harvard Medical School, and Division of Signal Transduction, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 101:3329-35. 2004
    ..Here we present biochemical and genetic evidence indicating that the LKB1 serine/threonine kinase, the gene inactivated in the Peutz-Jeghers familial cancer syndrome, is the dominant ..
  25. ncbi Identification of the sucrose non-fermenting related kinase SNRK, as a novel LKB1 substrate
    Mahaboobi Jaleel
    MRC Protein Phosphorylation Unit, MSI WTB complex, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, UK
    FEBS Lett 579:1417-23. 2005
    Recent work has shown that the LKB1 tumour suppressor protein kinase phosphorylates and activates protein kinases belonging to the AMP activated kinase (AMPK) subfamily...
  26. ncbi LKB1 interacts with and phosphorylates PTEN: a functional link between two proteins involved in cancer predisposing syndromes
    Hamid Mehenni
    Departement de Biologie Cellulaire, Universite de Geneve, 1211 Geneve 4, Switzerland
    Hum Mol Genet 14:2209-19. 2005
    Germline mutations of the LKB1 (STK11) tumor suppressor gene lead to Peutz-Jeghers syndrome (PJS) and predisposition to cancer. LKB1 encodes a serine/threonine kinase generally inactivated in PJS patients...
  27. pmc The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin
    Reuben J Shaw
    Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA
    Science 310:1642-6. 2005
    The Peutz-Jegher syndrome tumor-suppressor gene encodes a protein-threonine kinase, LKB1, which phosphorylates and activates AMPK [adenosine monophosphate (AMP)-activated protein kinase]...
  28. pmc Deficiency of LKB1 in heart prevents ischemia-mediated activation of AMPKalpha2 but not AMPKalpha1
    Kei Sakamoto
    Medical Research Council Protein Phosphorylation Unit, School of Life Sciences, Univ of Dundee, Dow St, Dundee DD1 5EH, UK
    Am J Physiol Endocrinol Metab 290:E780-8. 2006
    Recent studies indicate that the LKB1 is a key regulator of the AMP-activated protein kinase (AMPK), which plays a crucial role in protecting cardiac muscle from damage during ischemia...
  29. pmc Skeletal muscle-selective knockout of LKB1 increases insulin sensitivity, improves glucose homeostasis, and decreases TRB3
    Ho Jin Koh
    Research Division, Joslin Diabetes Center and Department of Medicine, Harvard Medical School, Boston, MA 02215, USA
    Mol Cell Biol 26:8217-27. 2006
    b>LKB1 is a tumor suppressor that may also be fundamental to cell metabolism, since LKB1 phosphorylates and activates the energy sensing enzyme AMPK...
  30. ncbi LKB1 and SAD kinases define a pathway required for the polarization of cortical neurons
    Anthony P Barnes
    Neuroscience Center, Department of Pharmacology, University of North Carolina, Chapel Hill, NC 27599, USA
    Cell 129:549-63. 2007
    ..We show here that the serine/threonine kinase LKB1, previously implicated in the establishment of epithelial polarity and control of cell growth, is required for axon ..
  31. ncbi LKB1/STRAD promotes axon initiation during neuronal polarization
    Maya Shelly
    Division of Neurobiology, Department of Molecular and Cell Biology, Helen Wills Neuroscience Institute, University of California, Berkeley, CA 94720, USA
    Cell 129:565-77. 2007
    ..In cultured hippocampal neurons, the accumulation of LKB1 and STRAD, two interacting proteins critical for establishing epithelial polarity, in an undifferentiated neurite ..
  32. ncbi Suppression of tubulin polymerization by the LKB1-microtubule-associated protein/microtubule affinity-regulating kinase signaling
    Yasushi Kojima
    Department of Pharmacology, Graduate School of Medicine, Kyoto University, Kyoto 606 8501, Japan
    J Biol Chem 282:23532-40. 2007
    b>LKB1, a tumor suppressor gene mutated in the Peutz-Jeghers syndrome, encodes a serine/threonine protein kinase...
  33. ncbi LKB1 modulates lung cancer differentiation and metastasis
    Hongbin Ji
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Nature 448:807-10. 2007
    Germline mutation in serine/threonine kinase 11 (STK11, also called LKB1) results in Peutz-Jeghers syndrome, characterized by intestinal hamartomas and increased incidence of epithelial cancers...
  34. pmc Mechanism of action of A-769662, a valuable tool for activation of AMP-activated protein kinase
    Olga Göransson
    Division for Diabetes, Metabolism and Endocrinology, Department of Experimental Medical Science, Lund University, Lund, Sweden
    J Biol Chem 282:32549-60. 2007
    ..Phosphorylation of AMPK and ACC in response to A-769662 is also abolished in isolated mouse skeletal muscle lacking LKB1, a major upstream kinase for AMPK in this tissue...
  35. ncbi LKB1 and the regulation of malonyl-CoA and fatty acid oxidation in muscle
    D M Thomson
    Dept of Physiology and Developmental Biology, Brigham Young Univ, Provo, UT 84602, USA
    Am J Physiol Endocrinol Metab 293:E1572-9. 2007
    ..In these tissues, LKB1 is the major AMPK kinase and is therefore critical for AMPK activation...
  36. pmc Normal hypertrophy accompanied by phosphoryation and activation of AMP-activated protein kinase alpha1 following overload in LKB1 knockout mice
    Sean L McGee
    Functional Molecular Biology Lab, Division of Molecular Physiology, University of Dundee, Sir James Black Centre, Dow Street, Dundee DD1 5EH, UK
    J Physiol 586:1731-41. 2008
    ..capacity for muscle growth was determined in mice lacking the primary upstream kinase for AMPK in skeletal muscle, LKB1. Following either 1 or 4 weeks of overload, there was no difference in muscle growth between the wild type (wt) and ..
  37. pmc Pancreatic LKB1 deletion leads to acinar polarity defects and cystic neoplasms
    Aram F Hezel
    MGH Cancer Center, Simches Research Building, CPZN 4216, 185 Cambridge St, Boston, MA 02114, USA
    Mol Cell Biol 28:2414-25. 2008
    b>LKB1 is a key regulator of energy homeostasis through the activation of AMP-activated protein kinase (AMPK) and is functionally linked to vascular development, cell polarity, and tumor suppression...
  38. doi Loss of Lkb1 provokes highly invasive endometrial adenocarcinomas
    Cristina M Contreras
    Department of Pathology, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9072, USA
    Cancer Res 68:759-66. 2008
    Mutations in the LKB1 tumor suppressor gene result in the Peutz-Jeghers syndrome, an autosomal dominant condition characterized by hamartomatous polyps of the gastrointestinal tract and a dramatically increased risk of epithelial ..
  39. doi LKB1 signaling in mesenchymal cells required for suppression of gastrointestinal polyposis
    Pekka Katajisto
    Genome Scale Biology Program and Institute of Biomedicine, Biomedicum Helsinki, 00014 University of Helsinki, Finland
    Nat Genet 40:455-9. 2008
    Germline mutations in STK11 (also known as LKB1) are found in individuals with Peutz-Jeghers syndrome (PJS) manifesting with gastrointestinal polyps that contain a prominent stromal component...
  40. doi Important role of the LKB1-AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice
    Xu Huang
    MRC Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK
    Biochem J 412:211-21. 2008
    The LKB1 tumour suppressor phosphorylates and activates AMPK (AMP-activated protein kinase) when cellular energy levels are low, thereby suppressing growth through multiple pathways, including inhibiting the mTORC1 (mammalian target of ..
  41. pmc LKB1 and AMPK and the regulation of skeletal muscle metabolism
    Ho Jin Koh
    Research Division, Joslin Diabetes Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA
    Curr Opin Clin Nutr Metab Care 11:227-32. 2008
    To address the role of LKB1 and AMP-activated protein kinase (AMPK) in glucose transport, fatty acid oxidation, and metabolic adaptations in skeletal muscle.
  42. doi LKB1 and lung cancer: more than the usual suspects
    Usman Shah
    Departments of Medicine and Genetics, The Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA
    Cancer Res 68:3562-5. 2008
    ..For LKB1, a more recently identified human tumor suppressor gene, however, the problem is different...
  43. doi LKB1 in endothelial cells is required for angiogenesis and TGFbeta-mediated vascular smooth muscle cell recruitment
    Anou Londesborough
    Genome Scale Biology Program and Institute of Biomedicine, Biomedicum Helsinki, 00014 University of Helsinki, Finland
    Development 135:2331-8. 2008
    Inactivation of the tumor suppressor kinase Lkb1 in mice leads to vascular defects and midgestational lethality at embryonic day 9-11 (E9-E11)...
  44. doi Lkb1 is required for TGFbeta-mediated myofibroblast differentiation
    Kari Vaahtomeri
    Genome Scale Biology Program, Institute of Biomedicine, Biomedicum Helsinki, P O Box 63, 00014 University of Helsinki, Finland
    J Cell Sci 121:3531-40. 2008
    Inactivating mutations of the tumor-suppressor kinase gene LKB1 underlie Peutz-Jeghers syndrome (PJS), which is characterized by gastrointestinal hamartomatous polyps with a prominent smooth-muscle and stromal component...
  45. doi Characterization of an alternative splice variant of LKB1
    Fiona C Denison
    Cellular Stress Group, Medical Research Council Clinical Sciences Centre, DuCane Road, London W12 0NN, United Kingdom
    J Biol Chem 284:67-76. 2009
    b>LKB1 is an upstream activating kinase for the AMP-activated protein kinase (AMPK) and at least 12 other AMPK-related kinases...
  46. pmc Lkb1 deficiency alters goblet and paneth cell differentiation in the small intestine
    Boris Y Shorning
    Cardiff School of Biosciences, Cardiff University, Cardiff, United Kingdom
    PLoS ONE 4:e4264. 2009
    The Lkb1 tumour suppressor is a multitasking kinase participating in a range of physiological processes...
  47. pmc Uncoupling of the LKB1-AMPKalpha energy sensor pathway by growth factors and oncogenic BRAF
    Rosaura Esteve-Puig
    Animal Models and Cancer Laboratory, Medical Oncology Research Program, Vall d Hebron Research Institute VHIO, Vall d Hebron Hospital, Barcelona, Spain
    PLoS ONE 4:e4771. 2009
    ..b>LKB1 is a multi-task Ser/Thr kinase that phosphorylates AMPK controlling cell growth and apoptosis under metabolic ..
  48. pmc mTOR and HIF-1alpha-mediated tumor metabolism in an LKB1 mouse model of Peutz-Jeghers syndrome
    David B Shackelford
    Dulbecco Center for Cancer Research, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 106:11137-42. 2009
    Peutz-Jeghers syndrome (PJS) is a familial cancer disorder due to inherited loss of function mutations in the LKB1/ STK11 serine/threonine kinase...
  49. doi Conditional deletion of the Lkb1 gene in the mouse mammary gland induces tumour formation
    Afshan McCarthy
    The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, Fulham Road, London SW3 6JB, UK
    J Pathol 219:306-16. 2009
    Heterozygous germline mutations in the LKB1 (STK11) gene cause Peutz-Jeghers syndrome (PJS), an autosomal dominant disorder characterized by hamartomatous polyposis of the gastrointestinal tract and an increased risk of colorectal, ..
  50. doi Loss of Lkb1 in adult beta cells increases beta cell mass and enhances glucose tolerance in mice
    Accalia Fu
    Apoptosis Research Centre, Children s Hospital of Eastern Ontario Research Institute, Ottawa, ON K1H 8L1, Canada
    Cell Metab 10:285-95. 2009
    The Lkb1 tumor suppressor exerts its biological effects through phosphorylation and consequent activation of the AMP kinase (AMPK) family...
  51. pmc LKB1 regulates pancreatic beta cell size, polarity, and function
    Zvi Granot
    Department of Developmental Biology and Cancer Research and Molecular Biology, The Institute for Medical Research Israel Canada, The Hebrew University Hadassah Medical School, Jerusalem 91120, Israel
    Cell Metab 10:296-308. 2009
    ..We have studied the roles of LKB1, a conserved kinase implicated in the control of cell polarity and energy metabolism, in adult beta cells...
  52. doi The serine/threonine kinase LKB1 controls thymocyte survival through regulation of AMPK activation and Bcl-XL expression
    Yonghao Cao
    Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    Cell Res 20:99-108. 2010
    b>LKB1 is a serine/threonine kinase that directly activates the energy sensor AMP-activated protein kinase (AMPK) in response to bioenergetic stress, and mainly acts as a tumor suppressor that controls cell polarity and proliferation...
  53. pmc LKB1 deletion with the RIP2.Cre transgene modifies pancreatic beta-cell morphology and enhances insulin secretion in vivo
    Gao Sun
    Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Imperial College London, London, UK
    Am J Physiol Endocrinol Metab 298:E1261-73. 2010
    The tumor suppressor liver kinase B1 (LKB1), also called STK11, is a protein kinase mutated in Peutz-Jeghers syndrome. LKB1 phosphorylates AMP-activated protein kinase (AMPK) and several related protein kinases...
  54. pmc Skeletal muscle dysfunction in muscle-specific LKB1 knockout mice
    David M Thomson
    Department of Physiology and Developmental Biology, 589 WIDB, Brigham Young University, Provo, UT 84602, USA
    J Appl Physiol (1985) 108:1775-85. 2010
    Liver kinase B1 (LKB1) is a tumor-suppressing protein that is involved in the regulation of muscle metabolism and growth by phosphorylating and activating AMP-activated protein kinase (AMPK) family members...
  55. pmc Impaired gastric gland differentiation in Peutz-Jeghers syndrome
    Lina Udd
    Institute of Biotechnology and Genome Scale Biology Research Program, University of Helsinki, Helsinki, Finland
    Am J Pathol 176:2467-76. 2010
    Gastrointestinal hamartomatous polyps in the Peutz-Jeghers cancer predisposition syndrome and its mouse model (Lkb1(+/-)) are presumed to contain all cell types native to the site of their occurrence...
  56. pmc STRADalpha deficiency results in aberrant mTORC1 signaling during corticogenesis in humans and mice
    Ksenia A Orlova
    Department of Neurology, PENN Epilepsy Center, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    J Clin Invest 120:1591-602. 2010
    ..STRADalpha normally binds and exports the protein kinase LKB1 out of the nucleus, leading to suppression of the mTORC1 pathway...
  57. pmc LKB1 haploinsufficiency cooperates with Kras to promote pancreatic cancer through suppression of p21-dependent growth arrest
    Jennifer P Morton
    Beatson Institute for Cancer Research, Garscube Estate, Glasgow, UK
    Gastroenterology 139:586-97, 597.e1-6. 2010
    Patients carrying germline mutations of LKB1 have an increased risk of pancreatic cancer; however, it is unclear whether down-regulation of LKB1 is an important event in sporadic pancreatic cancer...
  58. pmc Integrative genomic and proteomic analyses identify targets for Lkb1-deficient metastatic lung tumors
    Julian Carretero
    Department of Medical Oncology, Dana Farber Cancer Institute, 44 Binney Street, Boston, MA 02115 USA
    Cancer Cell 17:547-59. 2010
    In mice, Lkb1 deletion and activation of Kras(G12D) results in lung tumors with a high penetrance of lymph node and distant metastases...
  59. pmc Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state
    Marc Foretz
    Institut Cochin, Universite Paris Descartes, CNRS UMR 8104, Paris, France
    J Clin Invest 120:2355-69. 2010
    Metformin is widely used to treat hyperglycemia in individuals with type 2 diabetes. Recently the LKB1/AMP-activated protein kinase (LKB1/AMPK) pathway was proposed to mediate the action of metformin on hepatic gluconeogenesis...
  60. pmc Sucrose nonfermenting AMPK-related kinase (SNARK) mediates contraction-stimulated glucose transport in mouse skeletal muscle
    Ho Jin Koh
    Research Division, Joslin Diabetes Center and Department of Medicine, Harvard Medical School, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 107:15541-6. 2010
    ..Muscle-specific knockout of LKB1, an upstream kinase for AMPK and AMPK-related protein kinases, significantly inhibited contraction-stimulated ..
  61. pmc Negative regulation of TGFβ signaling by the kinase LKB1 and the scaffolding protein LIP1
    Anita Morén
    Ludwig Institute for Cancer Research, Uppsala University, Box 595, Biomedical Center, Uppsala University, SE 751 24 Uppsala, Sweden
    J Biol Chem 286:341-53. 2011
    ..Previous work established a protein complex between Smad4 and the scaffolding protein LKB1-interacting protein 1 (LIP1)...
  62. doi Diet and tumor LKB1 expression interact to determine sensitivity to anti-neoplastic effects of metformin in vivo
    C Algire
    E423 Segal Cancer Centre of the Jewish General Hospital, Departments of Experimental Medicine and Oncology, McGill University, Montreal, Quebec, Canada
    Oncogene 30:1174-82. 2011
    ..We treated both tumor LKB1 expression and host diet as variables, and observed that metformin inhibited tumor growth and reduced insulin ..
  63. pmc Lkb1 regulates quiescence and metabolic homeostasis of haematopoietic stem cells
    Boyi Gan
    Belfer Institute for Applied Cancer Science, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Nature 468:701-4. 2010
    ..How energy metabolism and stem-cell homeostatic processes are coordinated is not well understood. Lkb1 acts as an evolutionarily conserved regulator of cellular energy metabolism in eukaryotic cells and functions as ..
  64. pmc RIP2-mediated LKB1 deletion causes axon degeneration in the spinal cord and hind-limb paralysis
    Gao Sun
    Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Imperial College London, London, UK
    Dis Model Mech 4:193-202. 2011
    ..Here, we show that mice deleted for the tumour suppressor LKB1 (also called STK11) in the spinal cord, some parts of the brain and in the endocrine pancreas (βLKB1KO mice) develop hind-limb ..
  65. doi Phosphorylation of E3 ligase Smurf1 switches its substrate preference in support of axon development
    Pei Lin Cheng
    Division of Neurobiology, Department of Molecular and Cell Biology, and Helen Wills Neuroscience Institute, University of California, Berkeley, CA 94720, USA
    Neuron 69:231-43. 2011
    ..Thus, PKA-dependent phosphorylation of the E3 ligase could switch its substrate preference, contributing to selective protein degradation required for localized cellular function...
  66. doi The tumor suppressor kinase LKB1: lessons from mouse models
    Saara Ollila
    Institute of Biotechnology, University of Helsinki, Viikki Biocenter, Viikinkaari 9B, FIN 00014, Helsinki, Finland
    J Mol Cell Biol 3:330-40. 2011
    Mutations in the tumor suppressor gene LKB1 are important in hereditary Peutz-Jeghers syndrome, as well as in sporadic cancers including lung and cervical cancer...
  67. pmc LKB1 is an essential regulator of spermatozoa release during spermiation in the mammalian testis
    Fiona C Denison
    Medical Research Council s Clinical Sciences Centre, Imperial College, London, United Kingdom
    PLoS ONE 6:e28306. 2011
    b>LKB1 acts as a master upstream protein kinase regulating a number of kinases involved in diverse cellular functions. Recent studies have suggested a role for LKB1 in male fertility...
  68. pmc Tumor suppressor function of Liver kinase B1 (Lkb1) is linked to regulation of epithelial integrity
    Johanna I Partanen
    Institute of Biomedicine and Genome Scale Biology Research Program, Biomedicum Helsinki, University of Helsinki, 00014 Helsinki, Finland
    Proc Natl Acad Sci U S A 109:E388-97. 2012
    ..We show that conditional deletion of tumor suppressor gene Lkb1 (Par-4) in the mammary gland compromises epithelial integrity manifested by mislocalization of cell polarity ..
  69. pmc A murine lung cancer co-clinical trial identifies genetic modifiers of therapeutic response
    Zhao Chen
    Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 483:613-7. 2012
    ..Our studies demonstrate that concomitant loss of either p53 (also known as Tp53) or Lkb1 (also known as Stk11), two clinically relevant tumour suppressors, markedly impaired the response of Kras-mutant cancers to docetaxel ..
  70. pmc Lkb1 regulates organogenesis and early oncogenesis along AMPK-dependent and -independent pathways
    Bryan Lo
    Genentech, South San Francisco, CA 94080, USA
    J Cell Biol 199:1117-30. 2012
    The tumor suppressor Lkb1/STK11/Par-4 is a key regulator of cellular energy, proliferation, and polarity, yet its mechanisms of action remain poorly defined...
  71. pmc LKB1 regulates lipid oxidation during exercise independently of AMPK
    Jacob Jeppesen
    August Krogh Centre and Molecular Physiology Group, Department of Exercise and Sport Sciences, University of Copenhagen, Copenhagen, Denmark
    Diabetes 62:1490-9. 2013
    ..Here, we show that liver kinase B1 (LKB1) muscle-specific knockout (LKB1 MKO) mice display decreased fatty acid (FA) oxidation during treadmill exercise...
  72. pmc LKB1 inactivation dictates therapeutic response of non-small cell lung cancer to the metabolism drug phenformin
    David B Shackelford
    Molecular and Cell Biology Laboratory, Dulbecco Center for Cancer Research, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Cancer Cell 23:143-58. 2013
    The LKB1 (also called STK11) tumor suppressor is mutationally inactivated in ∼20% of non-small cell lung cancers (NSCLC)...
  73. pmc Metabolic and functional genomic studies identify deoxythymidylate kinase as a target in LKB1-mutant lung cancer
    Yan Liu
    Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Cancer Discov 3:870-9. 2013
    The LKB1/STK11 tumor suppressor encodes a serine/threonine kinase, which coordinates cell growth, polarity, motility, and metabolism...
  74. pmc Terminal axon branching is regulated by the LKB1-NUAK1 kinase pathway via presynaptic mitochondrial capture
    Julien Courchet
    Dorris Neuroscience Center and Department of Molecular and Cellular Neuroscience, The Scripps Research Institute, La Jolla, CA 92037 1000, USA
    Cell 153:1510-25. 2013
    ..We identified a pathway defined by two kinases, LKB1 and NUAK1, required for cortical axon branching in vivo...
  75. pmc Lkb1 loss promotes tumor progression of BRAF(V600E)-induced lung adenomas
    Elena González-Sánchez
    Animal Models and Cancer Laboratory, Anatomy Pathology Department, Vall d Hebron Institut of Research Autonomous University of Barcelona VHIR UAB Barcelona, Barcelona, Spain
    PLoS ONE 8:e66933. 2013
    Aberrant activation of MAP kinase signaling pathway and loss of tumor suppressor LKB1 have been implicated in lung cancer development and progression...
  76. ncbi The mouse Peutz-Jeghers syndrome gene Lkb1 encodes a nuclear protein kinase
    D P Smith
    Section of Gene Function and Regulation, Chester Beatty Laboratories, Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK
    Hum Mol Genet 8:1479-85. 1999
    The protein kinase gene LKB1 has recently been identified as the gene mutated in the Peutz-Jeghers cancer predisposition syndrome...
  77. pmc Identification and characterization of four novel phosphorylation sites (Ser31, Ser325, Thr336 and Thr366) on LKB1/STK11, the protein kinase mutated in Peutz-Jeghers cancer syndrome
    Gopal P Sapkota
    MRC Protein Phosphorylation Unit, MSI WTB complex, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, UK
    Biochem J 362:481-90. 2002
    ..The causative gene encodes a nuclear-localized protein kinase, termed LKB1, which is predicted to function as a tumour suppressor...
  78. doi Regulation of LKB1 expression by sex hormones in adipocytes
    K J McInnes
    Endocrinology Unit, BHF University Centre for Cardiovascular Science, Queen s Medical Research Institute, University of Edinburgh, Edinburgh, Scotland, UK
    Int J Obes (Lond) 36:982-5. 2012
    ..The purpose of this current study was to determine the underlying mechanisms whereby androgens and oestrogens can regulate AMPK phosphorylation in adipocytes, and whether this mechanism is receptor dependent...
  79. pmc Glucagon regulates ACC activity in adipocytes through the CAMKKβ/AMPK pathway
    I Chen Peng
    Division of Biomedical Sciences, University of California, Riverside, 92521, USA
    Am J Physiol Endocrinol Metab 302:E1560-8. 2012
    ..These results indicate that CaMKKβ/AMPK signaling is an important molecular component in regulating lipid metabolism in adipocytes responding to glucagon and could be a therapeutic target for the dysregulation of energy storage...
  80. pmc Hepatoma cells from mice deficient in glycine N-methyltransferase have increased RAS signaling and activation of liver kinase B1
    Nuria Martínez-López
    CIC bioGUNE, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Technology Park of Bizkaia, Bizkaia, Spain
    Gastroenterology 143:787-98.e1-13. 2012
    ..Mice that lack GNMT develop fibrosis and hepatomas and have alterations in signaling pathways involved in carcinogenesis. We investigated the role of GNMT in human HCC cell lines and in liver carcinogenesis in mice...
  81. pmc Paracrine Hedgehog signaling drives metabolic changes in hepatocellular carcinoma
    Isaac S Chan
    Division of Gastroenterology, Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Cancer Res 72:6344-50. 2012
    ..This discovery reveals new diagnostic and therapeutic targets that might be exploited to improve the outcomes of cirrhotic patients with HCCs...
  82. doi LKB1-regulated adaptive mechanisms are essential for neuronal survival following mitochondrial dysfunction
    Marc Germain
    Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada
    Hum Mol Genet 22:952-62. 2013
    ..Here, we identified the energy metabolism kinase LKB1 as a key regulator of the compensatory mechanisms activated in neurons, following mitochondrial dysfunction...
  83. pmc PGE(2) induces macrophage IL-10 production and a regulatory-like phenotype via a protein kinase A-SIK-CRTC3 pathway
    Kirsty F MacKenzie
    Medical Research Council Protein Phosphorylation Unit, Sir James Black Centre, College of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom
    J Immunol 190:565-77. 2013
    ..In line with this, we find that either genetic or pharmacological inhibition of salt-inducible kinases mimics the effect of PGE(2) on IL-10 production...
  84. pmc The tumor suppressor kinase LKB1 activates the downstream kinases SIK2 and SIK3 to stimulate nuclear export of class IIa histone deacetylases
    Donald R Walkinshaw
    Rosalind and Morris Goodman Cancer Research Center, McGill University, Montreal, Quebec H3A 1A3, Canada
    J Biol Chem 288:9345-62. 2013
    ..Here, we report that in a PKA-sensitive manner the tumor suppressor kinase LKB1 acts through salt-inducible kinase 2 (SIK2) and SIK3 to promote nucleocytoplasmic trafficking of class IIa HDACs...
  85. ncbi Expression of LKB1 and PTEN tumor suppressor genes during mouse embryonic development
    K Luukko
    Haartman Institute and Biocentrum Helsinki, P O Box 21, 00014 University of Helsinki, Helsinki, Finland
    Mech Dev 83:187-90. 1999
    Germ-line mutations of LKB1 and PTEN tumor suppressor genes underlie the phenotypically related Peutz-Jeghers syndrome (PJS) and Cowden disease (CD), respectively...
  86. ncbi Interaction of activator of G-protein signaling 3 (AGS3) with LKB1, a serine/threonine kinase involved in cell polarity and cell cycle progression: phosphorylation of the G-protein regulatory (GPR) motif as a regulatory mechanism for the interaction of GP
    Joe B Blumer
    Chugai Pharmaceutical Co, Ltd, Tsukuba Research Laboratory, 153 2 Nagai Niihari, Ibaraki 300 4101, Japan
    J Biol Chem 278:23217-20. 2003
    ..This screen identified the serine/threonine kinase LKB1, which is involved in the regulation of cell cycle progression and polarity...
  87. pmc Simultaneous expression of COX-2 and mPGES-1 in mouse gastrointestinal hamartomas
    H Takeda
    Department of Pharmacology, Kyoto University Graduate School of Medicine, Kyoto 606 8501, Japan
    Br J Cancer 90:701-4. 2004
    ..of both COX-2 and microsomal prostaglandin E(2) synthase (mPGES)-1 in gastrointestinal hamartomas developed in Lkb1(+/-), Smad4(+/-) and Cdx2(+/-)mice...
  88. ncbi Functional analysis of Peutz-Jeghers mutations reveals that the LKB1 C-terminal region exerts a crucial role in regulating both the AMPK pathway and the cell polarity
    Christelle Forcet
    Laboratoire Génétique Moléculaire, Signalisation et Cancer, CNRS UMR 5201, Domaine Rockfeller, Lyon, France
    Hum Mol Genet 14:1283-92. 2005
    Germline mutations of the LKB1 gene are responsible for the cancer-prone Peutz-Jeghers syndrome (PJS). LKB1 encodes a serine-threonine kinase that acts as a regulator of cell cycle, metabolism and cell polarity...
  89. ncbi Function of mammalian LKB1 and Ca2+/calmodulin-dependent protein kinase kinase alpha as Snf1-activating kinases in yeast
    Seung Pyo Hong
    Department of Genetics and Development, Columbia University, 701 W 168th Street, New York, NY 10032, USA
    J Biol Chem 280:21804-9. 2005
    ..The only established mammalian AMPK kinase is LKB1. We show that LKB1 functions heterologously in yeast...
  90. ncbi LKB1/PAR4 protein is asymmetrically localized in mouse oocytes and associates with meiotic spindle
    Katarzyna Szczepanska
    Department of Embryology, Institute of Zoology, Warsaw University, Miecznikowa 1, 02 096 Warszawa, Poland
    Gene Expr Patterns 6:86-93. 2005
    ..We showed that the LKB1 kinase, a mouse homologue of Caenorhabditis elegans PAR4 protein is asymmetrically localized to the animal pole of ..
  91. ncbi Accelerated onsets of gastric hamartomas and hepatic adenomas/carcinomas in Lkb1+/-p53-/- compound mutant mice
    H Takeda
    Department of Pharmacology, Graduate School of Medicine, Kyoto University, Kyoto 606 8501, Japan
    Oncogene 25:1816-20. 2006
    Germline mutations in the LKB1 gene are responsible for Peutz-Jeghers syndrome (PJS), which is characterized by gastrointestinal hamartomas and increasing risk of cancer...
  92. ncbi LKB1, an upstream AMPK kinase, regulates glucose and lipid metabolism in cultured liver and muscle cells
    Kenta Imai
    Division of Endocrinology and Diabetes, Department of Medicine, Saitama Medical School, Iruma gun, Saitama 350 0495, Japan
    Biochem Biophys Res Commun 351:595-601. 2006
    b>LKB1 is a 50 kDa serine/threonine kinase that phosphorylates and activates the catalytic subunit of AMPK at its T-loop residue Thr 172...
  93. pmc SIRT1 regulates hepatocyte lipid metabolism through activating AMP-activated protein kinase
    Xiuyun Hou
    Vascular Biology Unit and Molecular Cardiology Unit, Whitaker Cardiovascular Institute, Boston University School of Medicine, and Section of Endocrinology, Boston University, Boston, MA 02118, USA
    J Biol Chem 283:20015-26. 2008
    ..that polyphenols, including resveratrol and the synthetic polyphenol S17834, increase SIRT1 deacetylase activity, LKB1 phosphorylation at Ser(428), and AMPK activity...
  94. pmc Resveratrol inhibits cardiac hypertrophy via AMP-activated protein kinase and Akt
    Anita Y M Chan
    Cardiovascular Research Group and the Department of Pediatrics, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada
    J Biol Chem 283:24194-201. 2008
    ..via AMPK activation and Akt inhibition, and in the case of AMPK, is dependent on the presence of the AMPK kinase, LKB1. Taken together, our data suggest that resveratrol exerts anti-hypertrophic effects by activating AMPK via LKB1 and ..
  95. doi Tumor suppression by LKB1: SIK-ness prevents metastasis
    Reuben J Shaw
    Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Sci Signal 2:pe55. 2009
    The LKB1 serine-threonine kinase is a tumor suppressor that is inactivated in a large number of sporadic human lung non-small cell carcinomas (NSCLCs) and cervical cancers...
  96. pmc Cardiac-specific deletion of LKB1 leads to hypertrophy and dysfunction
    Yasumasa Ikeda
    Molecular Cardiology Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 284:35839-49. 2009
    b>LKB1 encodes a serine/threonine kinase, which functions upstream of the AMP-activated protein kinase (AMPK) superfamily...
  97. pmc Exogenous NAD blocks cardiac hypertrophic response via activation of the SIRT3-LKB1-AMP-activated kinase pathway
    Vinodkumar B Pillai
    Department of Surgery, University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 285:3133-44. 2010
    ..blocked the activation of pro-hypertrophic Akt1 signaling, and augmented the activity of anti-hypertrophic LKB1-AMPK signaling in the heart, which prevented subsequent induction of mTOR-mediated protein synthesis...
  98. pmc Improved myocardial perfusion in chronic diabetic mice by the up-regulation of pLKB1 and AMPK signaling
    Claudia Kusmic
    CNR Institute of Clinical Physiology, Pisa, Italy
    J Cell Biochem 109:1033-44. 2010
    ..The restoration of microvascular function suggests a new therapeutic approach to even advanced cardiac microvascular derangement in diabetes...
  99. pmc LKB1 suppresses p21-activated kinase-1 (PAK1) by phosphorylation of Thr109 in the p21-binding domain
    Atsuko Deguchi
    Department of Pharmacology, Graduate School of Medicine, Kyoto University, Kyoto 606 8501, Japan
    J Biol Chem 285:18283-90. 2010
    The serine/threonine protein kinase LKB1 is a tumor suppressor gene mutated in Peutz-Jeghers syndrome patients. The mutations are found also in several types of sporadic cancer...
  100. doi LKB1-mediated spatial control of GSK3beta and adenomatous polyposis coli contributes to centrosomal forward movement and neuronal migration in the developing neocortex
    Naoyuki Asada
    Molecular Genetics Research Laboratory, Graduate School of Science, The University of Tokyo, Bunkyo ku, Tokyo 113 0033, Japan
    J Neurosci 30:8852-65. 2010
    Neuronal migration is an essential process for the development of the cerebral cortex. We have previously shown that LKB1, an evolutionally conserved polarity kinase, plays a critical role in neuronal migration in the developing neocortex...
  101. pmc Deletion of Lkb1 in pro-opiomelanocortin neurons impairs peripheral glucose homeostasis in mice
    Marc Claret
    Laboratory of Diabetes and Obesity, Endocrinology and Nutrition Unit, Institut d Investigacions Biomediques August Pi i Sunyer, Hospital Clinic de Barcelona, Barcelona, Spain
    Diabetes 60:735-45. 2011
    ..Deletion of Ampkα2 in pro-opiomelanocortin (POMC) neurons causes obesity and defective neuronal glucose sensing. LKB1, the Peutz-Jeghers syndrome gene product, and Ca(2+)-calmodulin-dependent protein kinase kinase β (CaMKKβ) are ..