Stag2

Summary

Gene Symbol: Stag2
Description: stromal antigen 2
Alias: 9230105L23Rik, B230112I07Rik, SA-2, SAP2, cohesin subunit SA-2, SCC3 homolog 2, nuclear protein SA2
Species: mouse

Top Publications

  1. pmc STAG2 and Rad21 mammalian mitotic cohesins are implicated in meiosis
    Ignacio Prieto
    Department of Immunology and Oncology, Centro Nacional de Biotecnologia CSIC, UAM Campus de Cantoblanco, Madrid E 28049, Spain
    EMBO Rep 3:543-50. 2002
  2. pmc Reduction of Nipbl impairs cohesin loading locally and affects transcription but not cohesion-dependent functions in a mouse model of Cornelia de Lange Syndrome
    Silvia Remeseiro
    Chromosome Dynamics Group, Molecular Oncology Programme, Spanish National Cancer Research Centre CNIO, Melchor Fernandez Almagro 3, 28029 Madrid, Spain
    Biochim Biophys Acta 1832:2097-102. 2013
  3. pmc STAG3-mediated stabilization of REC8 cohesin complexes promotes chromosome synapsis during meiosis
    Tomoyuki Fukuda
    Graduate School of Biological Sciences, Nara Institute of Science and Technology, Nara, Japan Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden
    EMBO J 33:1243-55. 2014
  4. pmc Quantitative analysis of cohesin complex stoichiometry and SMC3 modification-dependent protein interactions
    Chen Ding
    Center for Molecular Discovery, Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Proteome Res 10:3652-9. 2011
  5. pmc Cohesin-SA1 deficiency drives aneuploidy and tumourigenesis in mice due to impaired replication of telomeres
    Silvia Remeseiro
    Chromosome Dynamics Group, Molecular Oncology Programme, Spanish National Cancer Research Centre CNIO, Madrid, Spain
    EMBO J 31:2076-89. 2012
  6. pmc A unique role of cohesin-SA1 in gene regulation and development
    Silvia Remeseiro
    Chromosome Dynamics Group, Molecular Oncology Programme, Spanish National Cancer Research Centre CNIO, Madrid, Spain
    EMBO J 31:2090-102. 2012
  7. pmc Cohesin regulates tissue-specific expression by stabilizing highly occupied cis-regulatory modules
    Andre J Faure
    European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, United Kingdom
    Genome Res 22:2163-75. 2012
  8. ncbi SA-1, a nuclear protein encoded by one member of a novel gene family: molecular cloning and detection in hemopoietic organs
    L Carramolino
    Pharmacia and Upjohn, R and D, Madrid, Spain
    Gene 195:151-9. 1997
  9. ncbi Evidence of a transcriptional co-activator function of cohesin STAG/SA/Scc3
    Enrique Lara-Pezzi
    Unidad de Biologia Molecular, Hospital de la Princesa, Diego de Leon, 62, 28006 Madrid, Spain
    J Biol Chem 279:6553-9. 2004
  10. pmc Mediator and cohesin connect gene expression and chromatin architecture
    Michael H Kagey
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nature 467:430-5. 2010

Scientific Experts

  • Silvia Remeseiro
  • Ana Cuadrado
  • Ana Losada
  • Tomoyuki Fukuda
  • Andre J Faure
  • Chen Ding
  • Florent Le Masson
  • Jibak Lee
  • Michael H Kagey
  • Ignacio Prieto
  • Enrique Lara-Pezzi
  • Candelas Carreiro
  • Nieves Pezzi
  • Alicia Martinez
  • Isabel Barthelemy
  • Christer Hoog
  • Anna Kouznetsova
  • Abrahan Hernández-Hernández
  • Ana Agostinho
  • Nanaho Fukuda
  • Arthur D Lander
  • Shimako Kawauchi
  • Anne L Calof
  • David G Pisano
  • Stephen Watt
  • Dominic Schmidt
  • Paul Flicek
  • Marta Canamero
  • María Carretero
  • Michael D Wilson
  • Maria A Blasco
  • Robert G Ramsay
  • Huiling Xu
  • William C Drosopoulos
  • Gonzalo Gomez-Lopez
  • Paula Martinez
  • Petra C Schwalie
  • Duncan T Odom
  • Carl L Schildkraut
  • Jun Qin
  • Yi Wang
  • Howard Cooke
  • Colette Charry
  • Anna Malovannaya
  • Zak Razak
  • Mo Kaigo
  • Tatsuya Hirano
  • Yehua Li
  • Sung Yun Jung
  • Christophe Audouard
  • Beom Jun Kim
  • J Timothy Westwood
  • Elisabeth S Christians
  • Jamie J Newman
  • Richard A Young
  • Steve Bilodeau
  • Dylan J Taatjes
  • Peter B Rahl
  • Job Dekker
  • Stuart S Levine
  • Christopher C Ebmeier
  • Jesse Goossens
  • Ye Zhan
  • David A Orlando
  • Nynke L van Berkum
  • L Carramolino
  • Alejandra Maldonado-Rodríguez
  • Manuel López-Cabrera
  • Jose Luis Barbero
  • Jose L Barbero
  • Raul Fernandez
  • Leonor Kremer
  • Lucio Gomez
  • Carlos Martinez-A
  • Jose M Buesa
  • Fernando Roncal
  • Y Shav-Tal
  • G Marquez
  • I Prieto
  • M Aracil
  • I Barthelemy
  • Y Gothelf
  • A Peled
  • A Zaballos
  • P Carmi
  • B C Lee
  • G Gonzalez De Buitrago
  • J L Barbero
  • D Zipori

Detail Information

Publications12

  1. pmc STAG2 and Rad21 mammalian mitotic cohesins are implicated in meiosis
    Ignacio Prieto
    Department of Immunology and Oncology, Centro Nacional de Biotecnologia CSIC, UAM Campus de Cantoblanco, Madrid E 28049, Spain
    EMBO Rep 3:543-50. 2002
    ..Two members of this family, STAG1/SA1 and STAG2/SA2,double dagger are classified as mitotic cohesins, as they are found in human somatic cells and in Xenopus ..
  2. pmc Reduction of Nipbl impairs cohesin loading locally and affects transcription but not cohesion-dependent functions in a mouse model of Cornelia de Lange Syndrome
    Silvia Remeseiro
    Chromosome Dynamics Group, Molecular Oncology Programme, Spanish National Cancer Research Centre CNIO, Melchor Fernandez Almagro 3, 28029 Madrid, Spain
    Biochim Biophys Acta 1832:2097-102. 2013
    ..These results provide further support for the idea that developmental defects in CdLS are caused by deregulated transcription and not by malfunction of cohesion-related processes. ..
  3. pmc STAG3-mediated stabilization of REC8 cohesin complexes promotes chromosome synapsis during meiosis
    Tomoyuki Fukuda
    Graduate School of Biological Sciences, Nara Institute of Science and Technology, Nara, Japan Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden
    EMBO J 33:1243-55. 2014
    ....
  4. pmc Quantitative analysis of cohesin complex stoichiometry and SMC3 modification-dependent protein interactions
    Chen Ding
    Center for Molecular Discovery, Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Proteome Res 10:3652-9. 2011
    ..We demonstrate that quantitative mass spectrometry is a powerful tool for measuring stoichiometry of endogenous protein core complex...
  5. pmc Cohesin-SA1 deficiency drives aneuploidy and tumourigenesis in mice due to impaired replication of telomeres
    Silvia Remeseiro
    Chromosome Dynamics Group, Molecular Oncology Programme, Spanish National Cancer Research Centre CNIO, Madrid, Spain
    EMBO J 31:2076-89. 2012
    ..We propose a novel mechanism for aneuploidy generation that involves impaired telomere replication upon loss of cohesin-SA1, with clear implications in tumourigenesis...
  6. pmc A unique role of cohesin-SA1 in gene regulation and development
    Silvia Remeseiro
    Chromosome Dynamics Group, Molecular Oncology Programme, Spanish National Cancer Research Centre CNIO, Madrid, Spain
    EMBO J 31:2090-102. 2012
    ..Lack of SA1 also alters cohesin-binding pattern along some gene clusters and leads to dysregulation of genes within. We hypothesize that impaired cohesin-SA1 function in gene expression underlies the molecular aetiology of CdLS...
  7. pmc Cohesin regulates tissue-specific expression by stabilizing highly occupied cis-regulatory modules
    Andre J Faure
    European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, United Kingdom
    Genome Res 22:2163-75. 2012
    ..Finally, we observe that the presence of mirrored CTCF binding events at promoters and their nearby cohesin-bound enhancers is associated with elevated expression levels...
  8. ncbi SA-1, a nuclear protein encoded by one member of a novel gene family: molecular cloning and detection in hemopoietic organs
    L Carramolino
    Pharmacia and Upjohn, R and D, Madrid, Spain
    Gene 195:151-9. 1997
    ..The SA-1 gene described in this study is highly conserved between mouse and man. This implies a crucial function for this protein...
  9. ncbi Evidence of a transcriptional co-activator function of cohesin STAG/SA/Scc3
    Enrique Lara-Pezzi
    Unidad de Biologia Molecular, Hospital de la Princesa, Diego de Leon, 62, 28006 Madrid, Spain
    J Biol Chem 279:6553-9. 2004
    ..Here we describe STAG/Scc3, which may act as a transcriptional co-activator. STAG2 is able to enhance the activity of the tumor necrosis factor alpha, the CD69, and the human immunodeficiency virus ..
  10. pmc Mediator and cohesin connect gene expression and chromatin architecture
    Michael H Kagey
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nature 467:430-5. 2010
    ..Mediator and cohesin co-occupy different promoters in different cells, thus generating cell-type-specific DNA loops linked to the gene expression program of each cell...
  11. pmc RAD21L, a novel cohesin subunit implicated in linking homologous chromosomes in mammalian meiosis
    Jibak Lee
    Chromosome Dynamics Laboratory, RIKEN Advanced Science Institute, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    J Cell Biol 192:263-76. 2011
    ..RAD21L associates with SMC3, STAG3, and either SMC1α or SMC1β. Our results suggest that cohesin complexes containing RAD21L may be involved in synapsis initiation and crossover recombination between homologous chromosomes...
  12. pmc Identification of heat shock factor 1 molecular and cellular targets during embryonic and adult female meiosis
    Florent Le Masson
    Université Toulouse 3, UPS, UMR 5547, Centre de Biologie du Developpement, 118 route de Narbonne Bat 4R3B3, 31062 Toulouse Cedex 09, France
    Mol Cell Biol 31:3410-23. 2011
    ..This work provides new insights into meiotic gene regulation and points out potential links between cellular stress and the meiotic anomalies frequently observed in humans...