Srebf2

Summary

Gene Symbol: Srebf2
Description: sterol regulatory element binding factor 2
Alias: AI608257, SREBP-2, SREBP2, SREBP2gc, bHLHd2, lop13, nuc, sterol regulatory element-binding protein 2, srebf2, sterol regulatory element-binding transcription factor 2
Species: mouse

Top Publications

  1. ncbi Sterol regulatory element-binding protein-1 as a key transcription factor for nutritional induction of lipogenic enzyme genes
    H Shimano
    Department of Metabolic Diseases, Faculty of Medicine, University of Tokyo, Tokyo 113 8655, Japan
    J Biol Chem 274:35832-9. 1999
  2. ncbi A novel interaction between lamin A and SREBP1: implications for partial lipodystrophy and other laminopathies
    David J Lloyd
    Division of Medical Genetics, Departments of Genetics and Medicine, University of Leicester, University Road, Leicester LE1 7RH, UK
    Hum Mol Genet 11:769-77. 2002
  3. ncbi Cloning and characterization of a mammalian fatty acyl-CoA elongase as a lipogenic enzyme regulated by SREBPs
    Takashi Matsuzaka
    Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, Ibaraki 305 8575, Japan
    J Lipid Res 43:911-20. 2002
  4. pmc Genome-wide localization of SREBP-2 in hepatic chromatin predicts a role in autophagy
    Young Kyo Seo
    Department of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, CA 92697, USA
    Cell Metab 13:367-75. 2011
  5. pmc Hepatic insulin receptor deficiency impairs the SREBP-2 response to feeding and statins
    Ji Miao
    Division of Endocrinology, Boston Children s Hospital, Harvard Medical School, Boston MA
    J Lipid Res 55:659-67. 2014
  6. pmc Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes
    Jay D Horton
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390 9046, USA
    Proc Natl Acad Sci U S A 100:12027-32. 2003
  7. doi Cholesterol accumulation and diabetes in pancreatic beta-cell-specific SREBP-2 transgenic mice: a new model for lipotoxicity
    Mayumi Ishikawa
    Department of Internal Medicine Endocrinology and Metabolism, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1 1 1 Tennodai, Tsukuba City, Ibaraki, Japan, 305 8575
    J Lipid Res 49:2524-34. 2008
  8. pmc SREBP-2 regulates gut peptide secretion through intestinal bitter taste receptor signaling in mice
    Tae Il Jeon
    Department of Molecular Biology and Biochemistry, University of California, Irvine, California, USA
    J Clin Invest 118:3693-700. 2008
  9. pmc Elevated levels of SREBP-2 and cholesterol synthesis in livers of mice homozygous for a targeted disruption of the SREBP-1 gene
    H Shimano
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75235, USA
    J Clin Invest 100:2115-24. 1997
  10. pmc Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a
    H Shimano
    Department of Molecular Genetics, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas 75235, USA
    J Clin Invest 98:1575-84. 1996

Research Grants

Scientific Experts

  • JAY HORTON
  • Shinya Hasegawa
  • Werner J Kovacs
  • Robert Ringseis
  • H Shimano
  • Cheng Ji
  • Carrie L Welch
  • R K Mallampalli
  • Christa Buechler
  • Robert H Baloh
  • Christine Y Ivashchenko
  • Jose Pena
  • Anne Beigneux
  • Charlotte Murphy
  • Timothy F Osborne
  • Tae Il Jeon
  • Young Kyo Seo
  • Laurent Vergnes
  • Zhen Chen
  • Tao Jiang
  • Nobuhiro Yamada
  • Takashi Matsuzaka
  • Naoya Yahagi
  • Akimitsu Takahashi
  • Hang Wang
  • S J H Ricoult
  • Bernice H Wong
  • Mayumi Ishikawa
  • Hirohito Sone
  • Jinsuk Kang
  • Young Chae Kim
  • Elizabeth J Tarling
  • Tatiana L Fonseca
  • R Stohr
  • Toyonori Kato
  • Xiang Wang
  • Karen Reue
  • David A Johnson
  • Hsien Da Huang
  • Ji Miao
  • Yang Zhang
  • John Y J Shyy
  • Madhuchhanda Mukherjee
  • Liang Wen
  • Ke Ma
  • Ting Yang Lin
  • Tiangang Li
  • Han Xiao
  • Kun ling Ma
  • Rongya Tao
  • Yoko Kidani
  • Wei Shao
  • Kensuke Yasui
  • Sarka Lhotak
  • Shiori Yamaguchi
  • Winnie Luu
  • Dong Ju Shin
  • Sudha B Biddinger
  • Xiong zhong Ruan
  • Sung Yun Cho
  • Sabrina Bauer
  • Kate M Merath
  • Timothy R Peterson
  • Shin Ichi Inoue
  • Feng Yan
  • Ryo Suzuki
  • Kihong Lim
  • S Hani Najafi-Shoushtari
  • Tyler J Marquart
  • Isabelle Gerin
  • Qiaohua Kang
  • Christian Bach
  • Bing Zhu
  • Hyun Jeong Jeong
  • Paul T Tarr
  • Mary K Bennett
  • Shin Kumadaki
  • Yoshimi Nakagawa
  • Takashi Yamamoto
  • Valérie Besnard
  • S Cases
  • Xiaobo Lin
  • A J Lusis
  • Noriyuki Inoue
  • Luke J Engelking
  • Scott E Liebman
  • Jinping Li
  • Moshe Levi
  • M Scott Lucia
  • Guoqiang Xu

Detail Information

Publications90

  1. ncbi Sterol regulatory element-binding protein-1 as a key transcription factor for nutritional induction of lipogenic enzyme genes
    H Shimano
    Department of Metabolic Diseases, Faculty of Medicine, University of Tokyo, Tokyo 113 8655, Japan
    J Biol Chem 274:35832-9. 1999
    ..These data demonstrate that SREBP-1 plays a crucial role in the induction of lipogenesis but not cholesterol biosynthesis in liver when excess energy by carbohydrates is consumed...
  2. ncbi A novel interaction between lamin A and SREBP1: implications for partial lipodystrophy and other laminopathies
    David J Lloyd
    Division of Medical Genetics, Departments of Genetics and Medicine, University of Leicester, University Road, Leicester LE1 7RH, UK
    Hum Mol Genet 11:769-77. 2002
    ....
  3. ncbi Cloning and characterization of a mammalian fatty acyl-CoA elongase as a lipogenic enzyme regulated by SREBPs
    Takashi Matsuzaka
    Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, Ibaraki 305 8575, Japan
    J Lipid Res 43:911-20. 2002
    ....
  4. pmc Genome-wide localization of SREBP-2 in hepatic chromatin predicts a role in autophagy
    Young Kyo Seo
    Department of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, CA 92697, USA
    Cell Metab 13:367-75. 2011
    ..Thus, the lipid droplet could be viewed as a third source of cellular cholesterol, which along with sterol synthesis and uptake, is also regulated by SREBP-2...
  5. pmc Hepatic insulin receptor deficiency impairs the SREBP-2 response to feeding and statins
    Ji Miao
    Division of Endocrinology, Boston Children s Hospital, Harvard Medical School, Boston MA
    J Lipid Res 55:659-67. 2014
    ..Taken together, these data indicate that cholesterol synthesis is a key target of insulin action in the liver. ..
  6. pmc Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes
    Jay D Horton
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390 9046, USA
    Proc Natl Acad Sci U S A 100:12027-32. 2003
    ....
  7. doi Cholesterol accumulation and diabetes in pancreatic beta-cell-specific SREBP-2 transgenic mice: a new model for lipotoxicity
    Mayumi Ishikawa
    Department of Internal Medicine Endocrinology and Metabolism, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1 1 1 Tennodai, Tsukuba City, Ibaraki, Japan, 305 8575
    J Lipid Res 49:2524-34. 2008
    ....
  8. pmc SREBP-2 regulates gut peptide secretion through intestinal bitter taste receptor signaling in mice
    Tae Il Jeon
    Department of Molecular Biology and Biochemistry, University of California, Irvine, California, USA
    J Clin Invest 118:3693-700. 2008
    ....
  9. pmc Elevated levels of SREBP-2 and cholesterol synthesis in livers of mice homozygous for a targeted disruption of the SREBP-1 gene
    H Shimano
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75235, USA
    J Clin Invest 100:2115-24. 1997
    ....
  10. pmc Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a
    H Shimano
    Department of Molecular Genetics, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas 75235, USA
    J Clin Invest 98:1575-84. 1996
    ..The amount of white adipose tissue decreased progressively as the liver enlarged. These studies indicate that the NH2-terminal domain of SREBP-1a can produce major effects on lipid synthesis and storage in the liver...
  11. doi Akt acutely activates the cholesterogenic transcription factor SREBP-2
    Winnie Luu
    School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW, Australia
    Biochim Biophys Acta 1823:458-64. 2012
    ..Together, this study provides compelling evidence that Akt contributes to the acute regulation of cholesterol metabolism through activating sterol-regulatory element binding protein-2...
  12. pmc A spontaneous mutation in Srebf2 leads to cataracts and persistent skin wounds in the lens opacity 13 (lop13) mouse
    Kate M Merath
    Department of Cell Biology, Neurobiology, and Anatomy, Human and Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, USA
    Mamm Genome 22:661-73. 2011
    ..analysis identified a C3112T mutation in exon 18 of Sterol Regulatory Element Binding-Transcription Factor 2 (Srebf2) resulting in the R1038C substitution of a highly conserved arginine within the Srebf2 regulatory domain...
  13. pmc Regulation of cholesterol and bile acid homeostasis by the cholesterol 7α-hydroxylase/steroid response element-binding protein 2/microRNA-33a axis in mice
    Tiangang Li
    Department of Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, OH, USA
    Hepatology 58:1111-21. 2013
    ..revealed that CYP7A1 overexpression led to marked activation of the steroid response element-binding protein 2 (SREBP2)-regulated cholesterol metabolic network and absence of bile acid repression of lipogenic gene expression in ..
  14. doi Sterol regulatory element-binding proteins are regulators of the NIS gene in thyroid cells
    Robert Ringseis
    Institute of Animal Nutrition and Nutrition Physiology, Justus Liebig Universität Gießen, Heinrich Buff Ring 26 32, 35392 Gießen, Germany
    Mol Endocrinol 27:781-800. 2013
    ..These findings show that TSH acts as a regulator of SREBP expression and maturation in thyroid epithelial cells and that SREBPs are novel transcriptional regulators of NIS...
  15. pmc An SREBP-responsive microRNA operon contributes to a regulatory loop for intracellular lipid homeostasis
    Tae Il Jeon
    Metabolic Signaling and Disease Program and Diabetes and Obesity Center, Sanford Burnham Medical Research Institute, Orlando, Florida 32827, USA
    Cell Metab 18:51-61. 2013
    ..These studies reveal an miRNA "operon" analogous to the classic model for genetic control in bacterial regulatory systems. ..
  16. pmc Sterol regulatory element binding protein 2 activation of NLRP3 inflammasome in endothelium mediates hemodynamic-induced atherosclerosis susceptibility
    Han Xiao
    Division of Biomedical Sciences, University of California, Riverside, USA
    Circulation 128:632-42. 2013
    ..Here, we explored whether disturbed flow patterns activate an innate immune response to form the NLRP3 inflammasome scaffold in vascular endothelial cells via sterol regulatory element binding protein 2 (SREBP2).
  17. pmc Hepatic SREBP-2 and cholesterol biosynthesis are regulated by FoxO3 and Sirt6
    Rongya Tao
    Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN
    J Lipid Res 54:2745-53. 2013
    ..Here we have identified sirtuin (Sirt)6 as a critical factor for Srebp2 gene regulation. Hepatic deficiency of Sirt6 in mice leads to elevated cholesterol levels...
  18. doi Activation of mTOR modulates SREBP-2 to induce foam cell formation through increased retinoblastoma protein phosphorylation
    Kun ling Ma
    Institute of Nephrology, Zhong Da Hospital, Southeast University School of Medicine, no 87, Ding Jia Qiao Road, Nanjing City, Jiangsu Province 210009, P R China
    Cardiovasc Res 100:450-60. 2013
    ..However, this effect is overridden by rapamycin, which is an inhibitor of mammalian target of rapamycin (mTOR). This study investigated the role of the mTOR pathway in atherosclerosis in vivo and in vitro...
  19. pmc Overactivation of intestinal SREBP2 in mice increases serum cholesterol
    Ke Ma
    Division of Gastroenterology and Hepatology, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, United States of America
    PLoS ONE 9:e84221. 2014
    Sterol Response Element Binding Protein 2 (SREBP2) transcription factor is a master regulator of cholesterol homeostasis...
  20. pmc Mfsd2a Is a Transporter for the Essential ω-3 Fatty Acid Docosahexaenoic Acid (DHA) in Eye and Is Important for Photoreceptor Cell Development
    Bernice H Wong
    From the Signature Research Program in Cardiovascular and Metabolic Disorders
    J Biol Chem 291:10501-14. 2016
    ..These findings identify LPC transport via Mfsd2a as an important pathway for DHA uptake in eye and for development of photoreceptor membrane discs. ..
  21. pmc SREBP-2-deficient and hypomorphic mice reveal roles for SREBP-2 in embryonic development and SREBP-1c expression
    Laurent Vergnes
    Departments of Human Genetics David Geffen School of Medicine at the University of California, Los Angeles, CA 90095
    J Lipid Res 57:410-21. 2016
    ..acid biosynthesis are regulated by the sterol regulatory element-binding proteins (SREBPs), encoded by Srebf1 and Srebf2. We generated mice that were either deficient or hypomorphic for SREBP-2...
  22. doi Leishmania donovani activates SREBP2 to modulate macrophage membrane cholesterol and mitochondrial oxidants for establishment of infection
    Madhuchhanda Mukherjee
    Infectious Diseases and Immunology Division, CSIR Indian Institute of Chemical Biology, Kolkata, India
    Int J Biochem Cell Biol 55:196-208. 2014
    ..Leishmania donovani, an intramacrophage pathogen, targets host SREBP2, a critical transcription factor, to regulate macrophage plasma membrane cholesterol and mitochondrial reactive ..
  23. pmc Oxidative stress activates endothelial innate immunity via sterol regulatory element binding protein 2 (SREBP2) transactivation of microRNA-92a
    Zhen Chen
    From Department of Medicine, School of Medicine Z C, L W, M M, L F, T Y L, M J C, Y I M, J Y J S and Department of Bioengineering S C, University of California, San Diego Department of Cardiovascular Sciences, Houston Methodist Medical Institute, Houston L F Biochemistry and Molecular Biology Graduate Program M M and Division of Biomedical Sciences, School of Medicine D A J, University of California, Riverside Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan C Y H, J W C, S J L, P H H Cardiovascular Research Center, National Yang Ming University, Taipei, Taiwan C Y H, J W C, S J L, P H H Institute of Bioinformatics and Systems Biology and Department of Biological Science and Technology, National Chiao Tung University, Hsin Chu, Taiwan F M L, H D H Department of Kinesiology and Health Sciences, California State University, San Bernardino G G and Cardiovascular Research Center, Medical School, Cellular Physiology Laboratory
    Circulation 131:805-14. 2015
    ..Here, we postulated that oxidative stress induces sterol regulatory element-binding protein 2 (SREBP2) and microRNA-92a (miR-92a), which in turn activate endothelial innate immune response, leading to dysfunctional ..
  24. pmc The nuclear receptor FXR uncouples the actions of miR-33 from SREBP-2
    Elizabeth J Tarling
    From the Division of Cardiology, Departments of Medicine E J T, H A, T Q d A V, and The Molecular Biology Institute E J T, University of California, Los Angeles
    Arterioscler Thromb Vasc Biol 35:787-95. 2015
    ..To determine whether activation of farnesoid X receptor (FXR) alters cellular and plasma cholesterol homeostasis as a result of regulation of Srebp-2 and miR-33...
  25. doi Matrix metalloproteinase-2 mediates a mechanism of metabolic cardioprotection consisting of negative regulation of the sterol regulatory element-binding protein-2/3-hydroxy-3-methylglutaryl-CoA reductase pathway in the heart
    Xiang Wang
    From the Departments of Biochemistry X W, E B, S H A, C F P and Physiology A T, Z K, Mazankowski Alberta Heart Institute Z K, C F P, Cardiovascular Research Group Z K, C F P, and Faculty of Medicine and Dentistry X W, E B, S H A, C F P, University of Alberta, Edmonton, Alberta, Canada
    Hypertension 65:882-8. 2015
    ..This complex phenotype is, at least in part, because of the cardiac sterol regulatory element-binding protein-2/3-hydroxy-3-methylglutaryl-coenzyme A reductase pathway being upregulated in MMP-2 deficiency. ..
  26. pmc ITCH modulates SIRT6 and SREBP2 to influence lipid metabolism and atherosclerosis in ApoE null mice
    R Stohr
    Department of Systems Medicine University of Rome Tor Vergata
    Sci Rep 5:9023. 2015
    ..the loss of ITCH lead to a reduction in circulating cholesterol levels through interference with nuclear SREBP2 clearance. This resulted in increased LDL reuptake through upregulation of LDL receptor expression...
  27. pmc Liver ChIP-seq analysis in FGF19-treated mice reveals SHP as a global transcriptional partner of SREBP-2
    Young Chae Kim
    Department of Molecular and Integrative Physiology, University of Illinois at Urbana Champaign, Urbana, IL, 61801, USA
    Genome Biol 16:268. 2015
    ..To explore global functions of SHP in mediating FGF19 action, we identify genome-wide SHP binding sites in hepatic chromatin in mice treated with vehicle or FGF19 by ChIP-seq analysis...
  28. pmc Oncogenic PI3K and K-Ras stimulate de novo lipid synthesis through mTORC1 and SREBP
    S J H Ricoult
    Department of Genetics and Complex Diseases, Harvard T H Chan School of Public Health, Boston, MA, USA
    Oncogene 35:1250-60. 2016
    ..eight breast cancer cell lines leads to activation of the sterol regulatory element-binding proteins (SREBP1 and SREBP2) that are required for oncogene-induced lipid synthesis...
  29. pmc Simultaneous deletion of the methylcytosine oxidases Tet1 and Tet3 increases transcriptome variability in early embryogenesis
    Jinsuk Kang
    Division of Signaling and Gene Expression, La Jolla Institute for Allergy and Immunology, CA 92037
    Proc Natl Acad Sci U S A 112:E4236-45. 2015
    ..Thus, TET enzymes and DNA cytosine modifications could directly or indirectly modulate transcriptional noise, resulting in the selective susceptibility of certain intracellular pathways to regulation by TET proteins. ..
  30. pmc Perinatal deiodinase 2 expression in hepatocytes defines epigenetic susceptibility to liver steatosis and obesity
    Tatiana L Fonseca
    Division of Endocrinology and Metabolism, Rush University Medical Center, Chicago, IL 60612
    Proc Natl Acad Sci U S A 112:14018-23. 2015
    ..The resulting phenotype of the adult ALB-D2KO mouse is dramatic, with greatly reduced susceptibility to diet-induced steatosis, hypertriglyceridemia, and obesity. ..
  31. pmc Peroxisome deficiency-induced ER stress and SREBP-2 pathway activation in the liver of newborn PEX2 knock-out mice
    Werner J Kovacs
    Institute of Cell Biology, ETH Zuerich, CH 8093 Zuerich, Switzerland
    Biochim Biophys Acta 1821:895-907. 2012
    ..These findings establish novel associations between SREBP-2, ER stress and PPARα pathway inductions...
  32. doi ER stress contributes to renal proximal tubule injury by increasing SREBP-2-mediated lipid accumulation and apoptotic cell death
    Sarka Lhotak
    Hamilton Centre for Kidney Research, St Joseph s Healthcare Hamilton, 50 Charlton Ave East, Hamilton, Ontario, Canada
    Am J Physiol Renal Physiol 303:F266-78. 2012
    ..In summary, our findings suggest that ER stress-induced SREBP-2 activation contributes to renal proximal tubule cell injury by dysregulating lipid homeostasis...
  33. ncbi ABCG1 and ABCG4 are coexpressed in neurons and astrocytes of the CNS and regulate cholesterol homeostasis through SREBP-2
    Paul T Tarr
    Department of Biological Chemistry, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095, USA
    J Lipid Res 49:169-82. 2008
    ..Based on the results of the current study, we propose that ABCG1 and ABCG4 mediate the intracellular vesicular transport of cholesterol/sterols within both neurons and astrocytes to regulate cholesterol transport in the brain...
  34. ncbi Sterol-dependent regulation of proprotein convertase subtilisin/kexin type 9 expression by sterol-regulatory element binding protein-2
    Hyun Jeong Jeong
    Department of Biochemistry, Kwandong University College of Medicine, Kangnung, Kangwon do 210 701, Korea
    J Lipid Res 49:399-409. 2008
    ..However, in vivo, it is suggested that the sterol-dependent regulation of PCSK9 is mediated predominantly by SREBP-2...
  35. ncbi Effects of a catechin-free fraction derived from green tea on gene expression of enzymes related to lipid metabolism in the mouse liver
    Kensuke Yasui
    Health Care Research Center, Nisshin Pharma Inc, Fujimino, Saitama 356 8511, Japan
    Biomed Res 33:9-13. 2012
    ..Also, the gene expression of sterol regulatory element-binding transcription factor (Srebf)1 and/or Srebf2 was reduced, suggesting that the reduction of Srebfs contributed to the down-regulation of the lipogenic enzymes, ..
  36. ncbi ACAT-2, a second mammalian acyl-CoA:cholesterol acyltransferase. Its cloning, expression, and characterization
    S Cases
    Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, California 94141, USA
    J Biol Chem 273:26755-64. 1998
    ..The identification and cloning of ACAT-2 will facilitate molecular approaches to understanding the role of ACAT enzymes in mammalian biology...
  37. pmc miR-33 links SREBP-2 induction to repression of sterol transporters
    Tyler J Marquart
    Edward A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University, St Louis, MO 63104, USA
    Proc Natl Acad Sci U S A 107:12228-32. 2010
    The sterol regulatory element binding protein 2 (SREBP-2) and the liver X receptor (LXR) control antagonistic transcriptional programs that stimulate cellular cholesterol uptake and synthesis, and cholesterol efflux, respectively...
  38. pmc Transcriptional activation of low-density lipoprotein receptor gene by DJ-1 and effect of DJ-1 on cholesterol homeostasis
    Shiori Yamaguchi
    Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan
    PLoS ONE 7:e38144. 2012
    ..This is the first report that DJ-1 participates in metabolism of fatty acid synthesis through transcriptional regulation of the LDLR gene...
  39. ncbi Sterol regulatory element-binding protein-2 interacts with hepatocyte nuclear factor-4 to enhance sterol isomerase gene expression in hepatocytes
    Koichi Misawa
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113 8657, Japan
    J Biol Chem 278:36176-82. 2003
    ..These data provide a novel pathway by which HNF-4 potentiates the SREBP functions and stimulates expression of SREBP-responsive genes in enterohepatic cells...
  40. pmc Expression of a novel, sterol-insensitive form of sterol regulatory element binding protein 2 (SREBP2) in male germ cells suggests important cell- and stage-specific functions for SREBP targets during spermatogenesis
    Hang Wang
    Department of Physiology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Mol Cell Biol 22:8478-90. 2002
    ..This protein, SREBP2gc, is expressed in a stage-dependent fashion as a soluble, constitutively active transcription factor that is not ..
  41. pmc Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins
    Daisuke Yabe
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390 9046, USA
    Proc Natl Acad Sci U S A 99:12753-8. 2002
    ..The combined actions of insig-1 and -2 permit feedback regulation of cholesterol synthesis over a wide range of sterol concentrations...
  42. pmc Sterol regulatory element-binding proteins are essential for the metabolic programming of effector T cells and adaptive immunity
    Yoko Kidani
    Institute for Molecular Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA
    Nat Immunol 14:489-99. 2013
    ..Our studies provide insights into the molecular signals that underlie the metabolic reprogramming of CD8(+) T cells during the transition from quiescence to activation...
  43. doi Acetoacetyl-CoA synthetase is essential for normal neuronal development
    Shinya Hasegawa
    Department of Health Chemistry, Hoshi University, Ebara, Shinagawa, Tokyo 142 8501, Japan
    Biochem Biophys Res Commun 427:398-403. 2012
    ..These results suggest that AACS is regulated by SREBP-2 and involves in the normal development of neurons...
  44. pmc Expanding roles for SREBP in metabolism
    Wei Shao
    Department of Cell Biology, Johns Hopkins University School of Medicine, 725 N Wolfe Street, Baltimore, MD 21205, USA
    Cell Metab 16:414-9. 2012
    ....
  45. doi Acetoacetyl-CoA synthetase, a ketone body-utilizing enzyme, is controlled by SREBP-2 and affects serum cholesterol levels
    Shinya Hasegawa
    Department of Health Chemistry, Hoshi University, 2 4 41 Ebara, Shinagawa ku, Tokyo 142 8501, Japan
    Mol Genet Metab 107:553-60. 2012
    ..These results suggest that ketone body metabolism via AACS activity plays an important role in cholesterol homeostasis...
  46. pmc Early dengue virus protein synthesis induces extensive rearrangement of the endoplasmic reticulum independent of the UPR and SREBP-2 pathway
    Jose Pena
    Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, California, United States of America
    PLoS ONE 7:e38202. 2012
    ..This work paves the way for further study of virally-induced membrane rearrangements and formation of cubic membranes...
  47. ncbi Thyroid hormone regulation and cholesterol metabolism are connected through Sterol Regulatory Element-Binding Protein-2 (SREBP-2)
    Dong Ju Shin
    Department of Molecular Biology and Biochemistry, University of California, Irvine, California 92697 3900, USA
    J Biol Chem 278:34114-8. 2003
    ..Additionally, these results indicate that mutations or drugs that lower nuclear SREBP-2 would cause hypercholesterolemia...
  48. doi Linalool reduces the expression of 3-hydroxy-3-methylglutaryl CoA reductase via sterol regulatory element binding protein-2- and ubiquitin-dependent mechanisms
    Sung Yun Cho
    Department of Biotechnology, The Graduate School of Biotechnology, Korea University, Seoul, Republic of Korea
    FEBS Lett 585:3289-96. 2011
    ..These findings suggest that food molecules with a pleasant scent could exert beneficial metabolic effects through multiple mechanisms...
  49. pmc mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway
    Timothy R Peterson
    Whitehead Institute for Biomedical Research, Koch Center for Integrative Cancer Research at MIT, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA
    Cell 146:408-20. 2011
    ..These findings establish lipin 1 as a key component of the mTORC1-SREBP pathway...
  50. pmc Prion-induced activation of cholesterogenic gene expression by Srebp2 in neuronal cells
    Christian Bach
    Institute of Virology, Technische Universitat Munchen, Trogerstrasse 30, 81675 Munich, Germany
    J Biol Chem 284:31260-9. 2009
    ..to a prion-dependent increase in the amount and activity of the sterol regulatory element-binding protein Srebp2, resulting in elevated levels of total and free cellular cholesterol...
  51. pmc Diabetes and insulin in regulation of brain cholesterol metabolism
    Ryo Suzuki
    Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA
    Cell Metab 12:567-79. 2010
    ..Thus, insulin and diabetes can alter brain cholesterol metabolism, and this may play an important role in the neurologic and metabolic dysfunction observed in diabetes and other disease states...
  52. doi Sterol regulatory element-binding protein 2 (SREBP2) activation after excess triglyceride storage induces chemerin in hypertrophic adipocytes
    Sabrina Bauer
    Department of Internal Medicine I, Regensburg University Hospital, D 93042 Regensburg, Germany
    Endocrinology 152:26-35. 2011
    ..Sterol regulatory element-binding protein 2 (SREBP2) was activated in these cells, indicative for cholesterol shortage...
  53. doi Activated sterol regulatory element-binding protein-2 suppresses hepatocyte nuclear factor-4-mediated Cyp3a11 expression in mouse liver
    Shin Ichi Inoue
    Division of Drug Metabolism and Molecular Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Miyagi 980 8578, Japan
    Mol Pharmacol 79:148-56. 2011
    ..This results in the reduced PGC-1α recruitment to HNF-4α on the Cyp3a11 promoter and the subsequent down-regulation of Cyp3a11 expression...
  54. pmc Expression of miR-33 from an SREBP2 intron inhibits cholesterol export and fatty acid oxidation
    Isabelle Gerin
    Laboratory for Physiological Chemistry, de Duve Institute, Universite Catholique de Louvain, 1200 Bruxelles, Belgium
    J Biol Chem 285:33652-61. 2010
    ..In this study, we provide evidence that the primary transcript of SREBP2 contains an intronic miRNA (miR-33) that reduces cellular cholesterol export via inhibition of translation of the ..
  55. ncbi Impaired regulation of sterol regulatory element binding protein 2 in cholesterol gallstone-susceptible mice
    Guoqiang Xu
    Division of Gastroenterology, Medical University of Schleswig Holstein Campus Lübeck, D 23538 Lubeck, Germany
    Biochim Biophys Acta 1688:274-9. 2004
    ..Lipid synthesis is under tight transcriptional control involving sterol regulatory element binding proteins (SREBP1, SREBP2)...
  56. ncbi Novel QTLs for HDL levels identified in mice by controlling for Apoa2 allelic effects: confirmation of a chromosome 6 locus in a congenic strain
    Carrie L Welch
    Division of Molecular Medicine, Department of Medicine, Columbia University, New York, New York 10032, USA
    Physiol Genomics 17:48-59. 2004
    ..003 and P = 0.0001 for HDL-C and non-HDL-C levels, respectively). These data are consistent with polygenic inheritance of HDL-C levels in the mouse model and provide candidate loci for HDL-C and non-HDL-C level determination in humans...
  57. pmc Disturbed cholesterol homeostasis in a peroxisome-deficient PEX2 knockout mouse model
    Werner J Kovacs
    Department of Biology, San Diego State University, San Diego, California 92182, USA
    Mol Cell Biol 24:1-13. 2004
    ....
  58. pmc ATP-citrate lyase deficiency in the mouse
    Anne P Beigneux
    Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, CA 94141, USA
    J Biol Chem 279:9557-64. 2004
    ..The Acly knockout allele is useful for identifying cell types with a high demand for acetyl-CoA synthesis...
  59. pmc Local regulation of fat metabolism in peripheral nerves
    Mark H G Verheijen
    Molecular Neurobiology Laboratory, The Salk Institute, La Jolla, California 92037, USA
    Genes Dev 17:2450-64. 2003
    ....
  60. ncbi Lanosterol metabolism and sterol regulatory element binding protein (SREBP) expression in male germ cell maturation
    Klementina Fon Tacer
    Institute of Biochemistry, Medical Center for Molecular Biology, Faculty of Medicine, University of Ljubljana, SI 1000 Ljubljana, Slovenia
    J Steroid Biochem Mol Biol 85:429-38. 2003
    ..spermatogenic cells was an enigma until recently, when a soluble, 55kDa cholesterol-insensitive form of SREBP2 (SREBP2gc) was discovered [Mol. Cell. Endocrinol. 22 (2002) 8478], being translated from a germ cell-specific SREBP2 mRNA...
  61. ncbi Acetyl-CoA carboxylase and SREBP expression during peripheral nervous system myelination
    Jerome Salles
    Laboratoire de Biogenese Membranaire, UMR CNRS 5544, Universite Victor Segalen Bordeaux 2, Bordeaux, France
    Biochim Biophys Acta 1631:229-38. 2003
    ..On the contrary, SREBP 2 mRNA quantities varied during the myelination period similarly to the lipogenic gene mRNAs, and the levels ..
  62. ncbi Tnfrsf13c (Baffr) is mis-expressed in tumors with murine leukemia virus insertions at Lvis22
    Kathryn E Hentges
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Genomics 80:204-12. 2002
    ..The characterization of these genes in tumor samples will allow a function to be assigned to many novel loci identified by the genome sequencing projects...
  63. pmc Novel role for a sterol response element binding protein in directing spermatogenic cell-specific gene expression
    Hang Wang
    Department of Physiology, University of Massachusetts Medical School, 55 Lake Avenue N, Worcester, MA 01655 0127 USA
    Mol Cell Biol 24:10681-8. 2004
    ..Sterol response element binding protein 2gc (SREBP2gc) is a spermatogenic cell-enriched isoform of the ubiquitous transcription factor SREBP2, which in somatic cells ..
  64. pmc Lipid deprivation increases surfactant phosphatidylcholine synthesis via a sterol-sensitive regulatory element within the CTP:phosphocholine cytidylyltransferase promoter
    Rama K Mallampalli
    The Veterans Administration Medical Center, Iowa City, IA 52246, U S A
    Biochem J 362:81-8. 2002
    ..These observations indicate that sterol-regulated expression of CCT is mediated by an SRE within its 5' flanking region...
  65. ncbi Acetyl-coenzyme A synthetase is a lipogenic enzyme controlled by SREBP-1 and energy status
    Hirohito Sone
    Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, Tsukuba 305 8575, Japan
    Am J Physiol Endocrinol Metab 282:E222-30. 2002
    ..However, its high conservation among different species and the wide range of its tissue distribution suggest that this enzyme might also play an important role in basic cellular energy metabolism...
  66. pmc Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta
    J J Repa
    Howard Hughes Medical Institute and Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Genes Dev 14:2819-30. 2000
    ..Because this active form of SREBP-1c controls the transcription of genes involved in fatty acid biosynthesis, our results reveal a unique regulatory interplay between cholesterol and fatty acid metabolism...
  67. ncbi Quantitative trait locus analysis of plasma lipoprotein levels in an autoimmune mouse model : interactions between lipoprotein metabolism, autoimmune disease, and atherogenesis
    L Gu
    Department of Medicine and Microbiology and Molecular Genetics Molecular Biology Institute, University of California Los Angeles, 90095 1679, USA
    Arterioscler Thromb Vasc Biol 19:442-53. 1999
    ..5 OD). Our results support the concept that the high prevalence of coronary artery disease in systemic lupus erythematosus is due in part to a reduction of HDL cholesterol levels resulting from the autoimmune disease...
  68. pmc Identification of a gene encoding an acyl CoA:diacylglycerol acyltransferase, a key enzyme in triacylglycerol synthesis
    S Cases
    Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 95:13018-23. 1998
    ..The identification of this cDNA encoding a DGAT will greatly facilitate studies of cellular glycerolipid metabolism and its regulation...
  69. ncbi Localization of profilin-1 (Pfn1) and a related sequence (Pfn1-rs) to mouse chromosomes 11 and 15 respectively
    M Klingenspor
    Lipid Research Laboratory, West Los Angeles VA Medical Center, Building 113, Room 312, 11301 Wilshire Blvd, Los Angeles, California 90073, USA
    Mamm Genome 8:539-40. 1997
  70. pmc Transgenic mice over-expressing the human spermidine synthase gene
    L Kauppinen
    Department of Biochemistry and Biotechnology, University of Kuopio, Finland
    Biochem J 293:513-6. 1993
    ....
  71. ncbi Sterol response element binding protein and thyroid transcription factor-1 (Nkx2.1) regulate Abca3 gene expression
    Valérie Besnard
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, OH 45229 3039, USA
    Am J Physiol Lung Cell Mol Physiol 293:L1395-405. 2007
    ..Abca3 gene expression is mediated by discrete cis-acting cassettes that mediate pulmonary cell- and lipid-sensitive pathways regulating surfactant homeostasis...
  72. pmc MicroRNA-33 and the SREBP host genes cooperate to control cholesterol homeostasis
    S Hani Najafi-Shoushtari
    Massachusetts General Hospital Cancer Center, Charlestown, MA 02129, USA
    Science 328:1566-9. 2010
    ..Our findings indicate that miR-33 acts in concert with the SREBP host genes to control cholesterol homeostasis and suggest that miR-33 may represent a therapeutic target for ameliorating cardiometabolic diseases...
  73. doi O-GlcNAc inhibits interaction between Sp1 and sterol regulatory element binding protein 2
    Kihong Lim
    Korea University, Anam Dong, Seongbuk gu, Seoul, Republic of Korea
    Biochem Biophys Res Commun 393:314-8. 2010
    ..Here we provide evidence that O-GlcNAc interrupts a known interaction between Sp1 and sterol regulatory element binding protein 2 (SREBP2), thereby inhibiting expression of the gene encoding acetyl-CoA synthetase 1, which is ..
  74. pmc Regulation of the ADMA-DDAH system in endothelial cells: a novel mechanism for the sterol response element binding proteins, SREBP1c and -2
    Christine Y Ivashchenko
    GlaxoSmithKline, Metabolic Pathways Center for Excellence in Drug Discovery, King of Prussia, PA 19406, USA
    Am J Physiol Heart Circ Physiol 298:H251-8. 2010
    ..knockdown of SREBP1c protein led to an increase in DDAH1 mRNA expression and activity, whereas the knockdown of SREBP2 led to a decrease in DDAH1 mRNA expression...
  75. pmc Curcumin inhibits srebp-2 expression in activated hepatic stellate cells in vitro by reducing the activity of specificity protein-1
    Qiaohua Kang
    Department of Pathology, School of Medicine, Saint Louis University, St Louis, Missouri 63104, USA
    Endocrinology 150:5384-94. 2009
    ..These results provide novel insights into molecular mechanisms by which curcumin inhibits LDL-induced HSC activation...
  76. ncbi Nucleotide sequence of mouse spermidine synthase cDNA
    S Myöhänen
    Department of Biochemistry and Biotechnology, University of Kuopio, Finland
    DNA Seq 4:343-6. 1994
    ..The open reading frame encoded a polypeptide of 302 amino acids, displaying 95% similarity to human and 33% similarity to E. coli spermidine synthase. The 3' flanking region contained an unusual polyadenylation signal AATACA...
  77. pmc Regulation of steroid 5-alpha reductase type 2 (Srd5a2) by sterol regulatory element binding proteins and statin
    Young Kyo Seo
    Department of Molecular Biology and Biochemistry, 3244 McGaugh Hall, University of California, UC Irvine, Irvine, CA 92697 3900, USA
    Exp Cell Res 315:3133-9. 2009
    ....
  78. pmc Congenital hypomyelinating neuropathy with lethal conduction failure in mice carrying the Egr2 I268N mutation
    Robert H Baloh
    Department of Neurology, and Hope Center for Neurological Diseases, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 29:2312-21. 2009
    ....
  79. pmc Peroxisome deficiency causes a complex phenotype because of hepatic SREBP/Insig dysregulation associated with endoplasmic reticulum stress
    Werner J Kovacs
    Institute of Cell Biology, ETH Zurich, CH 8093 Zurich, Switzerland
    J Biol Chem 284:7232-45. 2009
    ....
  80. pmc Selective binding of sterol regulatory element-binding protein isoforms and co-regulatory proteins to promoters for lipid metabolic genes in liver
    Mary K Bennett
    Department of Molecular Biology and Biochemistry, School of Biological Sciences and Center for Diabetes Research and Treatment, University of California, Irvine, California 92697 3900, USA
    J Biol Chem 283:15628-37. 2008
    ..This underscores the mechanistic flexibility that has evolved at the individual gene/promoter level to maintain metabolic homeostasis in response to shifting nutritional states and environmental fluctuations...
  81. doi [Inflammation enhances the accumulation of lipid in ApoE/SRA/CD36 KO mice liver]
    Feng Yan
    Center for Lipid Research, Key Laboratory of Molecular Biology on Infectious Diseases, Ministry of Education, Second Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China
    Zhonghua Gan Zang Bing Za Zhi 18:366-70. 2010
    ....
  82. ncbi Regulation by SREBP-2 defines a potential link between isoprenoid and adenosylcobalamin metabolism
    Charlotte Murphy
    Division of Clinical Chemistry, Department of Laboratory Medicine, Karolinska Institutet at Karolinska University Hospital, 14186 Stockholm, Sweden
    Biochem Biophys Res Commun 355:359-64. 2007
    ....
  83. ncbi Granuphilin is activated by SREBP-1c and involved in impaired insulin secretion in diabetic mice
    Toyonori Kato
    Department of Internal Medicine, Endocrinology and Metabolism, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1 1 1 Tennodai, Tsukuba Ibaraki 305 8575, Japan
    Cell Metab 4:143-54. 2006
    ..Collectively, our data provide evidence that activation of the SREBP-1c/granuphilin pathway is a potential mechanism for impaired insulin secretion in diabetes, contributing to beta cell lipotoxicity...
  84. ncbi Predominant role of sterol response element binding proteins (SREBP) lipogenic pathways in hepatic steatosis in the murine intragastric ethanol feeding model
    Cheng Ji
    USC UCLA Research Center for Alcoholic Liver and Pancreatic Diseases, Department of Medicine, Keck School of Medicine, University of Southern California, HMR 101, 2011 Zonal Avenue, Los Angeles, CA 90033, USA
    J Hepatol 45:717-24. 2006
    ..The contribution of SREBP-1c to alcohol-induced fatty liver and injury was studied...
  85. ncbi A targeted apoB38.9 mutation in mice is associated with reduced hepatic cholesterol synthesis and enhanced lipid peroxidation
    Xiaobo Lin
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    Am J Physiol Gastrointest Liver Physiol 290:G1170-6. 2006
    ..In contrast, apoB38.9 mice effectively maintain cholesterol homeostasis in the liver, at least in part, by reducing hepatic cholesterol synthesis...
  86. ncbi Role of altered renal lipid metabolism and the sterol regulatory element binding proteins in the pathogenesis of age-related renal disease
    Tao Jiang
    Division of Renal Diseases and Hypertension, Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Kidney Int 68:2608-20. 2005
    ..The purpose of this study was to identify a potential role for lipids in mediating age-related renal disease...
  87. pmc Schoenheimer effect explained--feedback regulation of cholesterol synthesis in mice mediated by Insig proteins
    Luke J Engelking
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9046, USA
    J Clin Invest 115:2489-98. 2005
    ..These studies indicate that the essential elements of the regulatory pathway for lipid synthesis function in liver as they do in cultured cells...
  88. ncbi Diet-induced obesity in C57BL/6J mice causes increased renal lipid accumulation and glomerulosclerosis via a sterol regulatory element-binding protein-1c-dependent pathway
    Tao Jiang
    Department of Medicine, The University of Colorado Health Sciences Center, Denver, 80262, USA
    J Biol Chem 280:32317-25. 2005
    ..Our results therefore suggest that diet-induced obesity causes increased renal lipid accumulation and glomerulosclerosis in C57BL/6J mice via an SREBP-1c-dependent pathway...
  89. ncbi SREBP transcription factors: master regulators of lipid homeostasis
    Delphine Eberle
    INSERM U465, Universite Pierre et Marie Curie, 15, rue de l Ecole de Medecine, 75270 Paris Cedex 06, France
    Biochimie 86:839-48. 2004
    ....

Research Grants5

  1. Transcriptional Regulation of a Surfactant Enzyme
    RAMA MALLAMPALLI; Fiscal Year: 2003
    ..Ultimately, the results from these studies could lead to therapeutic strategies directed at modulating expression of this key surfactant enzyme at the molecular level. ..
  2. Taskforce for Obesity Research at Southwestern (RMI)
    JAY HORTON; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  3. Pathogenesis of Obesity and Metabolic Syndrome
    JAY HORTON; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  4. Characterization of Microsomal Fatty Acid Elongation
    JAY HORTON; Fiscal Year: 2007
    ..abstract_text> ..