Genomes and Genes
Gene Symbol: Srebf2
Description: sterol regulatory element binding factor 2
Alias: AI608257, SREBP-2, SREBP2, SREBP2gc, bHLHd2, lop13, nuc, sterol regulatory element-binding protein 2, srebf2, sterol regulatory element-binding transcription factor 2
- Sterol regulatory element-binding protein-1 as a key transcription factor for nutritional induction of lipogenic enzyme genesH Shimano
Department of Metabolic Diseases, Faculty of Medicine, University of Tokyo, Tokyo 113 8655, Japan
J Biol Chem 274:35832-9. 1999..These data demonstrate that SREBP-1 plays a crucial role in the induction of lipogenesis but not cholesterol biosynthesis in liver when excess energy by carbohydrates is consumed...
- A novel interaction between lamin A and SREBP1: implications for partial lipodystrophy and other laminopathiesDavid J Lloyd
Division of Medical Genetics, Departments of Genetics and Medicine, University of Leicester, University Road, Leicester LE1 7RH, UK
Hum Mol Genet 11:769-77. 2002....
- Cloning and characterization of a mammalian fatty acyl-CoA elongase as a lipogenic enzyme regulated by SREBPsTakashi Matsuzaka
Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, Ibaraki 305 8575, Japan
J Lipid Res 43:911-20. 2002....
- Genome-wide localization of SREBP-2 in hepatic chromatin predicts a role in autophagyYoung Kyo Seo
Department of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, CA 92697, USA
Cell Metab 13:367-75. 2011..Thus, the lipid droplet could be viewed as a third source of cellular cholesterol, which along with sterol synthesis and uptake, is also regulated by SREBP-2...
- Hepatic insulin receptor deficiency impairs the SREBP-2 response to feeding and statinsJi Miao
Division of Endocrinology, Boston Children s Hospital, Harvard Medical School, Boston MA
J Lipid Res 55:659-67. 2014..Taken together, these data indicate that cholesterol synthesis is a key target of insulin action in the liver. ..
- Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genesJay D Horton
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390 9046, USA
Proc Natl Acad Sci U S A 100:12027-32. 2003....
- Cholesterol accumulation and diabetes in pancreatic beta-cell-specific SREBP-2 transgenic mice: a new model for lipotoxicityMayumi Ishikawa
Department of Internal Medicine Endocrinology and Metabolism, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1 1 1 Tennodai, Tsukuba City, Ibaraki, Japan, 305 8575
J Lipid Res 49:2524-34. 2008....
- SREBP-2 regulates gut peptide secretion through intestinal bitter taste receptor signaling in miceTae Il Jeon
Department of Molecular Biology and Biochemistry, University of California, Irvine, California, USA
J Clin Invest 118:3693-700. 2008....
- Elevated levels of SREBP-2 and cholesterol synthesis in livers of mice homozygous for a targeted disruption of the SREBP-1 geneH Shimano
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75235, USA
J Clin Invest 100:2115-24. 1997....
- Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1aH Shimano
Department of Molecular Genetics, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas 75235, USA
J Clin Invest 98:1575-84. 1996..The amount of white adipose tissue decreased progressively as the liver enlarged. These studies indicate that the NH2-terminal domain of SREBP-1a can produce major effects on lipid synthesis and storage in the liver...
- Akt acutely activates the cholesterogenic transcription factor SREBP-2Winnie Luu
School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW, Australia
Biochim Biophys Acta 1823:458-64. 2012..Together, this study provides compelling evidence that Akt contributes to the acute regulation of cholesterol metabolism through activating sterol-regulatory element binding protein-2...
- A spontaneous mutation in Srebf2 leads to cataracts and persistent skin wounds in the lens opacity 13 (lop13) mouseKate M Merath
Department of Cell Biology, Neurobiology, and Anatomy, Human and Molecular Genetics Center, Medical College of Wisconsin, Milwaukee, USA
Mamm Genome 22:661-73. 2011..analysis identified a C3112T mutation in exon 18 of Sterol Regulatory Element Binding-Transcription Factor 2 (Srebf2) resulting in the R1038C substitution of a highly conserved arginine within the Srebf2 regulatory domain...
- Regulation of cholesterol and bile acid homeostasis by the cholesterol 7α-hydroxylase/steroid response element-binding protein 2/microRNA-33a axis in miceTiangang Li
Department of Integrative Medical Sciences, Northeast Ohio Medical University, Rootstown, OH, USA
Hepatology 58:1111-21. 2013..revealed that CYP7A1 overexpression led to marked activation of the steroid response element-binding protein 2 (SREBP2)-regulated cholesterol metabolic network and absence of bile acid repression of lipogenic gene expression in ..
- Sterol regulatory element-binding proteins are regulators of the NIS gene in thyroid cellsRobert Ringseis
Institute of Animal Nutrition and Nutrition Physiology, Justus Liebig Universität Gießen, Heinrich Buff Ring 26 32, 35392 Gießen, Germany
Mol Endocrinol 27:781-800. 2013..These findings show that TSH acts as a regulator of SREBP expression and maturation in thyroid epithelial cells and that SREBPs are novel transcriptional regulators of NIS...
- An SREBP-responsive microRNA operon contributes to a regulatory loop for intracellular lipid homeostasisTae Il Jeon
Metabolic Signaling and Disease Program and Diabetes and Obesity Center, Sanford Burnham Medical Research Institute, Orlando, Florida 32827, USA
Cell Metab 18:51-61. 2013..These studies reveal an miRNA "operon" analogous to the classic model for genetic control in bacterial regulatory systems. ..
- Sterol regulatory element binding protein 2 activation of NLRP3 inflammasome in endothelium mediates hemodynamic-induced atherosclerosis susceptibilityHan Xiao
Division of Biomedical Sciences, University of California, Riverside, USA
Circulation 128:632-42. 2013..Here, we explored whether disturbed flow patterns activate an innate immune response to form the NLRP3 inflammasome scaffold in vascular endothelial cells via sterol regulatory element binding protein 2 (SREBP2).
- Hepatic SREBP-2 and cholesterol biosynthesis are regulated by FoxO3 and Sirt6Rongya Tao
Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN
J Lipid Res 54:2745-53. 2013..Here we have identified sirtuin (Sirt)6 as a critical factor for Srebp2 gene regulation. Hepatic deficiency of Sirt6 in mice leads to elevated cholesterol levels...
- Activation of mTOR modulates SREBP-2 to induce foam cell formation through increased retinoblastoma protein phosphorylationKun ling Ma
Institute of Nephrology, Zhong Da Hospital, Southeast University School of Medicine, no 87, Ding Jia Qiao Road, Nanjing City, Jiangsu Province 210009, P R China
Cardiovasc Res 100:450-60. 2013..However, this effect is overridden by rapamycin, which is an inhibitor of mammalian target of rapamycin (mTOR). This study investigated the role of the mTOR pathway in atherosclerosis in vivo and in vitro...
- Overactivation of intestinal SREBP2 in mice increases serum cholesterolKe Ma
Division of Gastroenterology and Hepatology, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, United States of America
PLoS ONE 9:e84221. 2014Sterol Response Element Binding Protein 2 (SREBP2) transcription factor is a master regulator of cholesterol homeostasis...
- Mfsd2a Is a Transporter for the Essential ω-3 Fatty Acid Docosahexaenoic Acid (DHA) in Eye and Is Important for Photoreceptor Cell DevelopmentBernice H Wong
From the Signature Research Program in Cardiovascular and Metabolic Disorders
J Biol Chem 291:10501-14. 2016..These findings identify LPC transport via Mfsd2a as an important pathway for DHA uptake in eye and for development of photoreceptor membrane discs. ..
- SREBP-2-deficient and hypomorphic mice reveal roles for SREBP-2 in embryonic development and SREBP-1c expressionLaurent Vergnes
Departments of Human Genetics David Geffen School of Medicine at the University of California, Los Angeles, CA 90095
J Lipid Res 57:410-21. 2016..acid biosynthesis are regulated by the sterol regulatory element-binding proteins (SREBPs), encoded by Srebf1 and Srebf2. We generated mice that were either deficient or hypomorphic for SREBP-2...
- Leishmania donovani activates SREBP2 to modulate macrophage membrane cholesterol and mitochondrial oxidants for establishment of infectionMadhuchhanda Mukherjee
Infectious Diseases and Immunology Division, CSIR Indian Institute of Chemical Biology, Kolkata, India
Int J Biochem Cell Biol 55:196-208. 2014..Leishmania donovani, an intramacrophage pathogen, targets host SREBP2, a critical transcription factor, to regulate macrophage plasma membrane cholesterol and mitochondrial reactive ..
- Oxidative stress activates endothelial innate immunity via sterol regulatory element binding protein 2 (SREBP2) transactivation of microRNA-92aZhen Chen
From Department of Medicine, School of Medicine Z C, L W, M M, L F, T Y L, M J C, Y I M, J Y J S and Department of Bioengineering S C, University of California, San Diego Department of Cardiovascular Sciences, Houston Methodist Medical Institute, Houston L F Biochemistry and Molecular Biology Graduate Program M M and Division of Biomedical Sciences, School of Medicine D A J, University of California, Riverside Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan C Y H, J W C, S J L, P H H Cardiovascular Research Center, National Yang Ming University, Taipei, Taiwan C Y H, J W C, S J L, P H H Institute of Bioinformatics and Systems Biology and Department of Biological Science and Technology, National Chiao Tung University, Hsin Chu, Taiwan F M L, H D H Department of Kinesiology and Health Sciences, California State University, San Bernardino G G and Cardiovascular Research Center, Medical School, Cellular Physiology Laboratory
Circulation 131:805-14. 2015..Here, we postulated that oxidative stress induces sterol regulatory element-binding protein 2 (SREBP2) and microRNA-92a (miR-92a), which in turn activate endothelial innate immune response, leading to dysfunctional ..
- The nuclear receptor FXR uncouples the actions of miR-33 from SREBP-2Elizabeth J Tarling
From the Division of Cardiology, Departments of Medicine E J T, H A, T Q d A V, and The Molecular Biology Institute E J T, University of California, Los Angeles
Arterioscler Thromb Vasc Biol 35:787-95. 2015..To determine whether activation of farnesoid X receptor (FXR) alters cellular and plasma cholesterol homeostasis as a result of regulation of Srebp-2 and miR-33...
- Matrix metalloproteinase-2 mediates a mechanism of metabolic cardioprotection consisting of negative regulation of the sterol regulatory element-binding protein-2/3-hydroxy-3-methylglutaryl-CoA reductase pathway in the heartXiang Wang
From the Departments of Biochemistry X W, E B, S H A, C F P and Physiology A T, Z K, Mazankowski Alberta Heart Institute Z K, C F P, Cardiovascular Research Group Z K, C F P, and Faculty of Medicine and Dentistry X W, E B, S H A, C F P, University of Alberta, Edmonton, Alberta, Canada
Hypertension 65:882-8. 2015..This complex phenotype is, at least in part, because of the cardiac sterol regulatory element-binding protein-2/3-hydroxy-3-methylglutaryl-coenzyme A reductase pathway being upregulated in MMP-2 deficiency. ..
- ITCH modulates SIRT6 and SREBP2 to influence lipid metabolism and atherosclerosis in ApoE null miceR Stohr
Department of Systems Medicine University of Rome Tor Vergata
Sci Rep 5:9023. 2015..the loss of ITCH lead to a reduction in circulating cholesterol levels through interference with nuclear SREBP2 clearance. This resulted in increased LDL reuptake through upregulation of LDL receptor expression...
- Liver ChIP-seq analysis in FGF19-treated mice reveals SHP as a global transcriptional partner of SREBP-2Young Chae Kim
Department of Molecular and Integrative Physiology, University of Illinois at Urbana Champaign, Urbana, IL, 61801, USA
Genome Biol 16:268. 2015..To explore global functions of SHP in mediating FGF19 action, we identify genome-wide SHP binding sites in hepatic chromatin in mice treated with vehicle or FGF19 by ChIP-seq analysis...
- Oncogenic PI3K and K-Ras stimulate de novo lipid synthesis through mTORC1 and SREBPS J H Ricoult
Department of Genetics and Complex Diseases, Harvard T H Chan School of Public Health, Boston, MA, USA
Oncogene 35:1250-60. 2016..eight breast cancer cell lines leads to activation of the sterol regulatory element-binding proteins (SREBP1 and SREBP2) that are required for oncogene-induced lipid synthesis...
- Simultaneous deletion of the methylcytosine oxidases Tet1 and Tet3 increases transcriptome variability in early embryogenesisJinsuk Kang
Division of Signaling and Gene Expression, La Jolla Institute for Allergy and Immunology, CA 92037
Proc Natl Acad Sci U S A 112:E4236-45. 2015..Thus, TET enzymes and DNA cytosine modifications could directly or indirectly modulate transcriptional noise, resulting in the selective susceptibility of certain intracellular pathways to regulation by TET proteins. ..
- Perinatal deiodinase 2 expression in hepatocytes defines epigenetic susceptibility to liver steatosis and obesityTatiana L Fonseca
Division of Endocrinology and Metabolism, Rush University Medical Center, Chicago, IL 60612
Proc Natl Acad Sci U S A 112:14018-23. 2015..The resulting phenotype of the adult ALB-D2KO mouse is dramatic, with greatly reduced susceptibility to diet-induced steatosis, hypertriglyceridemia, and obesity. ..
- Peroxisome deficiency-induced ER stress and SREBP-2 pathway activation in the liver of newborn PEX2 knock-out miceWerner J Kovacs
Institute of Cell Biology, ETH Zuerich, CH 8093 Zuerich, Switzerland
Biochim Biophys Acta 1821:895-907. 2012..These findings establish novel associations between SREBP-2, ER stress and PPARα pathway inductions...
- ER stress contributes to renal proximal tubule injury by increasing SREBP-2-mediated lipid accumulation and apoptotic cell deathSarka Lhotak
Hamilton Centre for Kidney Research, St Joseph s Healthcare Hamilton, 50 Charlton Ave East, Hamilton, Ontario, Canada
Am J Physiol Renal Physiol 303:F266-78. 2012..In summary, our findings suggest that ER stress-induced SREBP-2 activation contributes to renal proximal tubule cell injury by dysregulating lipid homeostasis...
- ABCG1 and ABCG4 are coexpressed in neurons and astrocytes of the CNS and regulate cholesterol homeostasis through SREBP-2Paul T Tarr
Department of Biological Chemistry, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095, USA
J Lipid Res 49:169-82. 2008..Based on the results of the current study, we propose that ABCG1 and ABCG4 mediate the intracellular vesicular transport of cholesterol/sterols within both neurons and astrocytes to regulate cholesterol transport in the brain...
- Sterol-dependent regulation of proprotein convertase subtilisin/kexin type 9 expression by sterol-regulatory element binding protein-2Hyun Jeong Jeong
Department of Biochemistry, Kwandong University College of Medicine, Kangnung, Kangwon do 210 701, Korea
J Lipid Res 49:399-409. 2008..However, in vivo, it is suggested that the sterol-dependent regulation of PCSK9 is mediated predominantly by SREBP-2...
- Effects of a catechin-free fraction derived from green tea on gene expression of enzymes related to lipid metabolism in the mouse liverKensuke Yasui
Health Care Research Center, Nisshin Pharma Inc, Fujimino, Saitama 356 8511, Japan
Biomed Res 33:9-13. 2012..Also, the gene expression of sterol regulatory element-binding transcription factor (Srebf)1 and/or Srebf2 was reduced, suggesting that the reduction of Srebfs contributed to the down-regulation of the lipogenic enzymes, ..
- ACAT-2, a second mammalian acyl-CoA:cholesterol acyltransferase. Its cloning, expression, and characterizationS Cases
Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, California 94141, USA
J Biol Chem 273:26755-64. 1998..The identification and cloning of ACAT-2 will facilitate molecular approaches to understanding the role of ACAT enzymes in mammalian biology...
- miR-33 links SREBP-2 induction to repression of sterol transportersTyler J Marquart
Edward A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University, St Louis, MO 63104, USA
Proc Natl Acad Sci U S A 107:12228-32. 2010The sterol regulatory element binding protein 2 (SREBP-2) and the liver X receptor (LXR) control antagonistic transcriptional programs that stimulate cellular cholesterol uptake and synthesis, and cholesterol efflux, respectively...
- Transcriptional activation of low-density lipoprotein receptor gene by DJ-1 and effect of DJ-1 on cholesterol homeostasisShiori Yamaguchi
Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan
PLoS ONE 7:e38144. 2012..This is the first report that DJ-1 participates in metabolism of fatty acid synthesis through transcriptional regulation of the LDLR gene...
- Sterol regulatory element-binding protein-2 interacts with hepatocyte nuclear factor-4 to enhance sterol isomerase gene expression in hepatocytesKoichi Misawa
Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113 8657, Japan
J Biol Chem 278:36176-82. 2003..These data provide a novel pathway by which HNF-4 potentiates the SREBP functions and stimulates expression of SREBP-responsive genes in enterohepatic cells...
- Expression of a novel, sterol-insensitive form of sterol regulatory element binding protein 2 (SREBP2) in male germ cells suggests important cell- and stage-specific functions for SREBP targets during spermatogenesisHang Wang
Department of Physiology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
Mol Cell Biol 22:8478-90. 2002..This protein, SREBP2gc, is expressed in a stage-dependent fashion as a soluble, constitutively active transcription factor that is not ..
- Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteinsDaisuke Yabe
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390 9046, USA
Proc Natl Acad Sci U S A 99:12753-8. 2002..The combined actions of insig-1 and -2 permit feedback regulation of cholesterol synthesis over a wide range of sterol concentrations...
- Sterol regulatory element-binding proteins are essential for the metabolic programming of effector T cells and adaptive immunityYoko Kidani
Institute for Molecular Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA
Nat Immunol 14:489-99. 2013..Our studies provide insights into the molecular signals that underlie the metabolic reprogramming of CD8(+) T cells during the transition from quiescence to activation...
- Acetoacetyl-CoA synthetase is essential for normal neuronal developmentShinya Hasegawa
Department of Health Chemistry, Hoshi University, Ebara, Shinagawa, Tokyo 142 8501, Japan
Biochem Biophys Res Commun 427:398-403. 2012..These results suggest that AACS is regulated by SREBP-2 and involves in the normal development of neurons...
- Expanding roles for SREBP in metabolismWei Shao
Department of Cell Biology, Johns Hopkins University School of Medicine, 725 N Wolfe Street, Baltimore, MD 21205, USA
Cell Metab 16:414-9. 2012....
- Acetoacetyl-CoA synthetase, a ketone body-utilizing enzyme, is controlled by SREBP-2 and affects serum cholesterol levelsShinya Hasegawa
Department of Health Chemistry, Hoshi University, 2 4 41 Ebara, Shinagawa ku, Tokyo 142 8501, Japan
Mol Genet Metab 107:553-60. 2012..These results suggest that ketone body metabolism via AACS activity plays an important role in cholesterol homeostasis...
- Early dengue virus protein synthesis induces extensive rearrangement of the endoplasmic reticulum independent of the UPR and SREBP-2 pathwayJose Pena
Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, California, United States of America
PLoS ONE 7:e38202. 2012..This work paves the way for further study of virally-induced membrane rearrangements and formation of cubic membranes...
- Thyroid hormone regulation and cholesterol metabolism are connected through Sterol Regulatory Element-Binding Protein-2 (SREBP-2)Dong Ju Shin
Department of Molecular Biology and Biochemistry, University of California, Irvine, California 92697 3900, USA
J Biol Chem 278:34114-8. 2003..Additionally, these results indicate that mutations or drugs that lower nuclear SREBP-2 would cause hypercholesterolemia...
- Linalool reduces the expression of 3-hydroxy-3-methylglutaryl CoA reductase via sterol regulatory element binding protein-2- and ubiquitin-dependent mechanismsSung Yun Cho
Department of Biotechnology, The Graduate School of Biotechnology, Korea University, Seoul, Republic of Korea
FEBS Lett 585:3289-96. 2011..These findings suggest that food molecules with a pleasant scent could exert beneficial metabolic effects through multiple mechanisms...
- mTOR complex 1 regulates lipin 1 localization to control the SREBP pathwayTimothy R Peterson
Whitehead Institute for Biomedical Research, Koch Center for Integrative Cancer Research at MIT, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA
Cell 146:408-20. 2011..These findings establish lipin 1 as a key component of the mTORC1-SREBP pathway...
- Prion-induced activation of cholesterogenic gene expression by Srebp2 in neuronal cellsChristian Bach
Institute of Virology, Technische Universitat Munchen, Trogerstrasse 30, 81675 Munich, Germany
J Biol Chem 284:31260-9. 2009..to a prion-dependent increase in the amount and activity of the sterol regulatory element-binding protein Srebp2, resulting in elevated levels of total and free cellular cholesterol...
- Diabetes and insulin in regulation of brain cholesterol metabolismRyo Suzuki
Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA
Cell Metab 12:567-79. 2010..Thus, insulin and diabetes can alter brain cholesterol metabolism, and this may play an important role in the neurologic and metabolic dysfunction observed in diabetes and other disease states...
- Sterol regulatory element-binding protein 2 (SREBP2) activation after excess triglyceride storage induces chemerin in hypertrophic adipocytesSabrina Bauer
Department of Internal Medicine I, Regensburg University Hospital, D 93042 Regensburg, Germany
Endocrinology 152:26-35. 2011..Sterol regulatory element-binding protein 2 (SREBP2) was activated in these cells, indicative for cholesterol shortage...
- Activated sterol regulatory element-binding protein-2 suppresses hepatocyte nuclear factor-4-mediated Cyp3a11 expression in mouse liverShin Ichi Inoue
Division of Drug Metabolism and Molecular Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Miyagi 980 8578, Japan
Mol Pharmacol 79:148-56. 2011..This results in the reduced PGC-1α recruitment to HNF-4α on the Cyp3a11 promoter and the subsequent down-regulation of Cyp3a11 expression...
- Expression of miR-33 from an SREBP2 intron inhibits cholesterol export and fatty acid oxidationIsabelle Gerin
Laboratory for Physiological Chemistry, de Duve Institute, Universite Catholique de Louvain, 1200 Bruxelles, Belgium
J Biol Chem 285:33652-61. 2010..In this study, we provide evidence that the primary transcript of SREBP2 contains an intronic miRNA (miR-33) that reduces cellular cholesterol export via inhibition of translation of the ..
- Impaired regulation of sterol regulatory element binding protein 2 in cholesterol gallstone-susceptible miceGuoqiang Xu
Division of Gastroenterology, Medical University of Schleswig Holstein Campus Lübeck, D 23538 Lubeck, Germany
Biochim Biophys Acta 1688:274-9. 2004..Lipid synthesis is under tight transcriptional control involving sterol regulatory element binding proteins (SREBP1, SREBP2)...
- Novel QTLs for HDL levels identified in mice by controlling for Apoa2 allelic effects: confirmation of a chromosome 6 locus in a congenic strainCarrie L Welch
Division of Molecular Medicine, Department of Medicine, Columbia University, New York, New York 10032, USA
Physiol Genomics 17:48-59. 2004..003 and P = 0.0001 for HDL-C and non-HDL-C levels, respectively). These data are consistent with polygenic inheritance of HDL-C levels in the mouse model and provide candidate loci for HDL-C and non-HDL-C level determination in humans...
- Disturbed cholesterol homeostasis in a peroxisome-deficient PEX2 knockout mouse modelWerner J Kovacs
Department of Biology, San Diego State University, San Diego, California 92182, USA
Mol Cell Biol 24:1-13. 2004....
- ATP-citrate lyase deficiency in the mouseAnne P Beigneux
Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, CA 94141, USA
J Biol Chem 279:9557-64. 2004..The Acly knockout allele is useful for identifying cell types with a high demand for acetyl-CoA synthesis...
- Local regulation of fat metabolism in peripheral nervesMark H G Verheijen
Molecular Neurobiology Laboratory, The Salk Institute, La Jolla, California 92037, USA
Genes Dev 17:2450-64. 2003....
- Lanosterol metabolism and sterol regulatory element binding protein (SREBP) expression in male germ cell maturationKlementina Fon Tacer
Institute of Biochemistry, Medical Center for Molecular Biology, Faculty of Medicine, University of Ljubljana, SI 1000 Ljubljana, Slovenia
J Steroid Biochem Mol Biol 85:429-38. 2003..spermatogenic cells was an enigma until recently, when a soluble, 55kDa cholesterol-insensitive form of SREBP2 (SREBP2gc) was discovered [Mol. Cell. Endocrinol. 22 (2002) 8478], being translated from a germ cell-specific SREBP2 mRNA...
- Acetyl-CoA carboxylase and SREBP expression during peripheral nervous system myelinationJerome Salles
Laboratoire de Biogenese Membranaire, UMR CNRS 5544, Universite Victor Segalen Bordeaux 2, Bordeaux, France
Biochim Biophys Acta 1631:229-38. 2003..On the contrary, SREBP 2 mRNA quantities varied during the myelination period similarly to the lipogenic gene mRNAs, and the levels ..
- Tnfrsf13c (Baffr) is mis-expressed in tumors with murine leukemia virus insertions at Lvis22Kathryn E Hentges
Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
Genomics 80:204-12. 2002..The characterization of these genes in tumor samples will allow a function to be assigned to many novel loci identified by the genome sequencing projects...
- Novel role for a sterol response element binding protein in directing spermatogenic cell-specific gene expressionHang Wang
Department of Physiology, University of Massachusetts Medical School, 55 Lake Avenue N, Worcester, MA 01655 0127 USA
Mol Cell Biol 24:10681-8. 2004..Sterol response element binding protein 2gc (SREBP2gc) is a spermatogenic cell-enriched isoform of the ubiquitous transcription factor SREBP2, which in somatic cells ..
- Lipid deprivation increases surfactant phosphatidylcholine synthesis via a sterol-sensitive regulatory element within the CTP:phosphocholine cytidylyltransferase promoterRama K Mallampalli
The Veterans Administration Medical Center, Iowa City, IA 52246, U S A
Biochem J 362:81-8. 2002..These observations indicate that sterol-regulated expression of CCT is mediated by an SRE within its 5' flanking region...
- Acetyl-coenzyme A synthetase is a lipogenic enzyme controlled by SREBP-1 and energy statusHirohito Sone
Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, Tsukuba 305 8575, Japan
Am J Physiol Endocrinol Metab 282:E222-30. 2002..However, its high conservation among different species and the wide range of its tissue distribution suggest that this enzyme might also play an important role in basic cellular energy metabolism...
- Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbetaJ J Repa
Howard Hughes Medical Institute and Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
Genes Dev 14:2819-30. 2000..Because this active form of SREBP-1c controls the transcription of genes involved in fatty acid biosynthesis, our results reveal a unique regulatory interplay between cholesterol and fatty acid metabolism...
- Quantitative trait locus analysis of plasma lipoprotein levels in an autoimmune mouse model : interactions between lipoprotein metabolism, autoimmune disease, and atherogenesisL Gu
Department of Medicine and Microbiology and Molecular Genetics Molecular Biology Institute, University of California Los Angeles, 90095 1679, USA
Arterioscler Thromb Vasc Biol 19:442-53. 1999..5 OD). Our results support the concept that the high prevalence of coronary artery disease in systemic lupus erythematosus is due in part to a reduction of HDL cholesterol levels resulting from the autoimmune disease...
- Identification of a gene encoding an acyl CoA:diacylglycerol acyltransferase, a key enzyme in triacylglycerol synthesisS Cases
Gladstone Institute of Cardiovascular Disease, University of California, San Francisco, CA 94143, USA
Proc Natl Acad Sci U S A 95:13018-23. 1998..The identification of this cDNA encoding a DGAT will greatly facilitate studies of cellular glycerolipid metabolism and its regulation...
- Localization of profilin-1 (Pfn1) and a related sequence (Pfn1-rs) to mouse chromosomes 11 and 15 respectivelyM Klingenspor
Lipid Research Laboratory, West Los Angeles VA Medical Center, Building 113, Room 312, 11301 Wilshire Blvd, Los Angeles, California 90073, USA
Mamm Genome 8:539-40. 1997
- Transgenic mice over-expressing the human spermidine synthase geneL Kauppinen
Department of Biochemistry and Biotechnology, University of Kuopio, Finland
Biochem J 293:513-6. 1993....
- Sterol response element binding protein and thyroid transcription factor-1 (Nkx2.1) regulate Abca3 gene expressionValérie Besnard
Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, OH 45229 3039, USA
Am J Physiol Lung Cell Mol Physiol 293:L1395-405. 2007..Abca3 gene expression is mediated by discrete cis-acting cassettes that mediate pulmonary cell- and lipid-sensitive pathways regulating surfactant homeostasis...
- MicroRNA-33 and the SREBP host genes cooperate to control cholesterol homeostasisS Hani Najafi-Shoushtari
Massachusetts General Hospital Cancer Center, Charlestown, MA 02129, USA
Science 328:1566-9. 2010..Our findings indicate that miR-33 acts in concert with the SREBP host genes to control cholesterol homeostasis and suggest that miR-33 may represent a therapeutic target for ameliorating cardiometabolic diseases...
- O-GlcNAc inhibits interaction between Sp1 and sterol regulatory element binding protein 2Kihong Lim
Korea University, Anam Dong, Seongbuk gu, Seoul, Republic of Korea
Biochem Biophys Res Commun 393:314-8. 2010..Here we provide evidence that O-GlcNAc interrupts a known interaction between Sp1 and sterol regulatory element binding protein 2 (SREBP2), thereby inhibiting expression of the gene encoding acetyl-CoA synthetase 1, which is ..
- Regulation of the ADMA-DDAH system in endothelial cells: a novel mechanism for the sterol response element binding proteins, SREBP1c and -2Christine Y Ivashchenko
GlaxoSmithKline, Metabolic Pathways Center for Excellence in Drug Discovery, King of Prussia, PA 19406, USA
Am J Physiol Heart Circ Physiol 298:H251-8. 2010..knockdown of SREBP1c protein led to an increase in DDAH1 mRNA expression and activity, whereas the knockdown of SREBP2 led to a decrease in DDAH1 mRNA expression...
- Curcumin inhibits srebp-2 expression in activated hepatic stellate cells in vitro by reducing the activity of specificity protein-1Qiaohua Kang
Department of Pathology, School of Medicine, Saint Louis University, St Louis, Missouri 63104, USA
Endocrinology 150:5384-94. 2009..These results provide novel insights into molecular mechanisms by which curcumin inhibits LDL-induced HSC activation...
- Nucleotide sequence of mouse spermidine synthase cDNAS Myöhänen
Department of Biochemistry and Biotechnology, University of Kuopio, Finland
DNA Seq 4:343-6. 1994..The open reading frame encoded a polypeptide of 302 amino acids, displaying 95% similarity to human and 33% similarity to E. coli spermidine synthase. The 3' flanking region contained an unusual polyadenylation signal AATACA...
- Regulation of steroid 5-alpha reductase type 2 (Srd5a2) by sterol regulatory element binding proteins and statinYoung Kyo Seo
Department of Molecular Biology and Biochemistry, 3244 McGaugh Hall, University of California, UC Irvine, Irvine, CA 92697 3900, USA
Exp Cell Res 315:3133-9. 2009....
- Congenital hypomyelinating neuropathy with lethal conduction failure in mice carrying the Egr2 I268N mutationRobert H Baloh
Department of Neurology, and Hope Center for Neurological Diseases, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Neurosci 29:2312-21. 2009....
- Peroxisome deficiency causes a complex phenotype because of hepatic SREBP/Insig dysregulation associated with endoplasmic reticulum stressWerner J Kovacs
Institute of Cell Biology, ETH Zurich, CH 8093 Zurich, Switzerland
J Biol Chem 284:7232-45. 2009....
- Selective binding of sterol regulatory element-binding protein isoforms and co-regulatory proteins to promoters for lipid metabolic genes in liverMary K Bennett
Department of Molecular Biology and Biochemistry, School of Biological Sciences and Center for Diabetes Research and Treatment, University of California, Irvine, California 92697 3900, USA
J Biol Chem 283:15628-37. 2008..This underscores the mechanistic flexibility that has evolved at the individual gene/promoter level to maintain metabolic homeostasis in response to shifting nutritional states and environmental fluctuations...
- [Inflammation enhances the accumulation of lipid in ApoE/SRA/CD36 KO mice liver]Feng Yan
Center for Lipid Research, Key Laboratory of Molecular Biology on Infectious Diseases, Ministry of Education, Second Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China
Zhonghua Gan Zang Bing Za Zhi 18:366-70. 2010....
- Regulation by SREBP-2 defines a potential link between isoprenoid and adenosylcobalamin metabolismCharlotte Murphy
Division of Clinical Chemistry, Department of Laboratory Medicine, Karolinska Institutet at Karolinska University Hospital, 14186 Stockholm, Sweden
Biochem Biophys Res Commun 355:359-64. 2007....
- Granuphilin is activated by SREBP-1c and involved in impaired insulin secretion in diabetic miceToyonori Kato
Department of Internal Medicine, Endocrinology and Metabolism, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1 1 1 Tennodai, Tsukuba Ibaraki 305 8575, Japan
Cell Metab 4:143-54. 2006..Collectively, our data provide evidence that activation of the SREBP-1c/granuphilin pathway is a potential mechanism for impaired insulin secretion in diabetes, contributing to beta cell lipotoxicity...
- Predominant role of sterol response element binding proteins (SREBP) lipogenic pathways in hepatic steatosis in the murine intragastric ethanol feeding modelCheng Ji
USC UCLA Research Center for Alcoholic Liver and Pancreatic Diseases, Department of Medicine, Keck School of Medicine, University of Southern California, HMR 101, 2011 Zonal Avenue, Los Angeles, CA 90033, USA
J Hepatol 45:717-24. 2006..The contribution of SREBP-1c to alcohol-induced fatty liver and injury was studied...
- A targeted apoB38.9 mutation in mice is associated with reduced hepatic cholesterol synthesis and enhanced lipid peroxidationXiaobo Lin
Department of Medicine, Washington University School of Medicine, St Louis, Missouri, USA
Am J Physiol Gastrointest Liver Physiol 290:G1170-6. 2006..In contrast, apoB38.9 mice effectively maintain cholesterol homeostasis in the liver, at least in part, by reducing hepatic cholesterol synthesis...
- Role of altered renal lipid metabolism and the sterol regulatory element binding proteins in the pathogenesis of age-related renal diseaseTao Jiang
Division of Renal Diseases and Hypertension, Department of Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
Kidney Int 68:2608-20. 2005..The purpose of this study was to identify a potential role for lipids in mediating age-related renal disease...
- Schoenheimer effect explained--feedback regulation of cholesterol synthesis in mice mediated by Insig proteinsLuke J Engelking
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9046, USA
J Clin Invest 115:2489-98. 2005..These studies indicate that the essential elements of the regulatory pathway for lipid synthesis function in liver as they do in cultured cells...
- Diet-induced obesity in C57BL/6J mice causes increased renal lipid accumulation and glomerulosclerosis via a sterol regulatory element-binding protein-1c-dependent pathwayTao Jiang
Department of Medicine, The University of Colorado Health Sciences Center, Denver, 80262, USA
J Biol Chem 280:32317-25. 2005..Our results therefore suggest that diet-induced obesity causes increased renal lipid accumulation and glomerulosclerosis in C57BL/6J mice via an SREBP-1c-dependent pathway...
- SREBP transcription factors: master regulators of lipid homeostasisDelphine Eberle
INSERM U465, Universite Pierre et Marie Curie, 15, rue de l Ecole de Medecine, 75270 Paris Cedex 06, France
Biochimie 86:839-48. 2004....
- Transcriptional Regulation of a Surfactant EnzymeRAMA MALLAMPALLI; Fiscal Year: 2003..Ultimately, the results from these studies could lead to therapeutic strategies directed at modulating expression of this key surfactant enzyme at the molecular level. ..
- Taskforce for Obesity Research at Southwestern (RMI)JAY HORTON; Fiscal Year: 2006..unreadable] [unreadable]..
- Pathogenesis of Obesity and Metabolic SyndromeJAY HORTON; Fiscal Year: 2006..unreadable] [unreadable] [unreadable]..
- Characterization of Microsomal Fatty Acid ElongationJAY HORTON; Fiscal Year: 2007..abstract_text> ..