Gene Symbol: Srb7
Description: mediator complex subunit 21
Alias: 0610007L03Rik, AI449604, D19234, D6Ertd782e, Srb7, Surb7, RNA polymerase II holoenzyme component SRB7, RNAPII complex component SRB7, SRB7 (supressor of RNA polymerase B) homolog, mediator of RNA polymerase II transcription subunit 21
- Mammalian mediator of transcriptional regulation and its possible role as an end-point of signal transduction pathwaysY W Jiang
Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
Proc Natl Acad Sci U S A 95:8538-43. 1998..Mediator of transcriptional regulation on the basis of the following: homologs of two subunits of yeast Mediator, Srb7 and Med7, copurify with the complex; peptide sequencing reveals, in addition, homologs of the yeast Mediator ..
- Ubiquitous expression and embryonic requirement for RNA polymerase II coactivator subunit Srb7 in miceM Tudor
Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142 USA
Genes Dev 13:2365-8. 1999..We have isolated the murine gene encoding Srb7, an Srb/Med complex protein whose sequence and function is highly conserved between yeast and humans...
- The TRAP100 component of the TRAP/Mediator complex is essential in broad transcriptional events and developmentMitsuhiro Ito
Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, NY 10021, USA
EMBO J 21:3464-75. 2002....
- Structural and functional organization of TRAP220, the TRAP/mediator subunit that is targeted by nuclear receptorsSohail Malik
Laboratory of Biochemistry and Molecular Biology, Rockefeller University, 1230 York Ave, New York, NY 10021, USA
Mol Cell Biol 24:8244-54. 2004..The implications of these observations are discussed in terms of our present understanding of coactivator function...
- The Mediator complex protein Med31 is required for embryonic growth and cell proliferation during mammalian developmentMichael D Risley
University of Manchester, Faculty of Life Sciences, Manchester, UK
Dev Biol 342:146-56. 2010..As the Mediator complex is a transcriptional co-activator, our results suggest that Med31 functions to promote the transcription of genes required for embryonic growth and cell proliferation...
- Mediator and cohesin connect gene expression and chromatin architectureMichael H Kagey
Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
Nature 467:430-5. 2010..Mediator and cohesin co-occupy different promoters in different cells, thus generating cell-type-specific DNA loops linked to the gene expression program of each cell...