Srb7

Summary

Gene Symbol: Srb7
Description: mediator complex subunit 21
Alias: 0610007L03Rik, AI449604, D19234, D6Ertd782e, Srb7, Surb7, RNA polymerase II holoenzyme component SRB7, RNAPII complex component SRB7, SRB7 (supressor of RNA polymerase B) homolog, mediator of RNA polymerase II transcription subunit 21
Species: mouse

Top Publications

  1. pmc Mammalian mediator of transcriptional regulation and its possible role as an end-point of signal transduction pathways
    Y W Jiang
    Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 95:8538-43. 1998
  2. pmc Ubiquitous expression and embryonic requirement for RNA polymerase II coactivator subunit Srb7 in mice
    M Tudor
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142 USA
    Genes Dev 13:2365-8. 1999
  3. pmc The TRAP100 component of the TRAP/Mediator complex is essential in broad transcriptional events and development
    Mitsuhiro Ito
    Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, NY 10021, USA
    EMBO J 21:3464-75. 2002
  4. pmc Structural and functional organization of TRAP220, the TRAP/mediator subunit that is targeted by nuclear receptors
    Sohail Malik
    Laboratory of Biochemistry and Molecular Biology, Rockefeller University, 1230 York Ave, New York, NY 10021, USA
    Mol Cell Biol 24:8244-54. 2004
  5. doi The Mediator complex protein Med31 is required for embryonic growth and cell proliferation during mammalian development
    Michael D Risley
    University of Manchester, Faculty of Life Sciences, Manchester, UK
    Dev Biol 342:146-56. 2010
  6. pmc Mediator and cohesin connect gene expression and chromatin architecture
    Michael H Kagey
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nature 467:430-5. 2010

Detail Information

Publications6

  1. pmc Mammalian mediator of transcriptional regulation and its possible role as an end-point of signal transduction pathways
    Y W Jiang
    Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 95:8538-43. 1998
    ..Mediator of transcriptional regulation on the basis of the following: homologs of two subunits of yeast Mediator, Srb7 and Med7, copurify with the complex; peptide sequencing reveals, in addition, homologs of the yeast Mediator ..
  2. pmc Ubiquitous expression and embryonic requirement for RNA polymerase II coactivator subunit Srb7 in mice
    M Tudor
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142 USA
    Genes Dev 13:2365-8. 1999
    ..We have isolated the murine gene encoding Srb7, an Srb/Med complex protein whose sequence and function is highly conserved between yeast and humans...
  3. pmc The TRAP100 component of the TRAP/Mediator complex is essential in broad transcriptional events and development
    Mitsuhiro Ito
    Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, NY 10021, USA
    EMBO J 21:3464-75. 2002
    ....
  4. pmc Structural and functional organization of TRAP220, the TRAP/mediator subunit that is targeted by nuclear receptors
    Sohail Malik
    Laboratory of Biochemistry and Molecular Biology, Rockefeller University, 1230 York Ave, New York, NY 10021, USA
    Mol Cell Biol 24:8244-54. 2004
    ..The implications of these observations are discussed in terms of our present understanding of coactivator function...
  5. doi The Mediator complex protein Med31 is required for embryonic growth and cell proliferation during mammalian development
    Michael D Risley
    University of Manchester, Faculty of Life Sciences, Manchester, UK
    Dev Biol 342:146-56. 2010
    ..As the Mediator complex is a transcriptional co-activator, our results suggest that Med31 functions to promote the transcription of genes required for embryonic growth and cell proliferation...
  6. pmc Mediator and cohesin connect gene expression and chromatin architecture
    Michael H Kagey
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nature 467:430-5. 2010
    ..Mediator and cohesin co-occupy different promoters in different cells, thus generating cell-type-specific DNA loops linked to the gene expression program of each cell...