Sptb

Summary

Gene Symbol: Sptb
Description: spectrin beta, erythrocytic
Alias: AI842465, D330027P03Rik, Gm1301, Spnb-1, Spnb1, jaundiced, mKIAA4219, spectrin beta chain, erythrocytic, beta-I spectrin, beta-spectrin 1, brain erythroid spectrin (235E), spectrin R, spectrin beta 1, spectrin beta chain, erythrocyte
Species: mouse

Top Publications

  1. ncbi Developmental expression of brain beta-spectrin isoform messenger RNAs
    W E Zimmer
    Department of Structural and Cellular Biology, College of Medicine, University of South Alabama, Mobile 36688
    Brain Res 594:75-83. 1992
  2. pmc Chromosomal location of three spectrin genes: relationship to the inherited hemolytic anemias of mouse and man
    C S Birkenmeier
    Jackson Laboratory, Bar Harbor, ME 04609
    Proc Natl Acad Sci U S A 85:8121-5. 1988
  3. ncbi Isolation of a cDNA encoding thymic shared antigen-1. A new member of the Ly6 family with a possible role in T cell development
    I MacNeil
    Department of Immunology, DNAX Research Institute, Palo Alto, CA 94304
    J Immunol 151:6913-23. 1993
  4. pmc Cell organization, growth, and neural and cardiac development require αII-spectrin
    Michael C Stankewich
    Department of Pathology, Yale University School of Medicine, 310 Cedar St BML 150, New Haven, CT 06520, USA
    J Cell Sci 124:3956-66. 2011
  5. pmc The carboxyterminal EF domain of erythroid alpha-spectrin is necessary for optimal spectrin-actin binding
    Catherine Korsgren
    Division of Hematology Oncology, Department of Medicine, Children s Hospital Boston, Boston, MA 02115, USA
    Blood 116:2600-7. 2010
  6. ncbi Growth and dissemination of Lewis lung carcinoma in plasminogen-deficient mice
    T H Bugge
    Divisions of Developmental Biology and Pathology, Children s Hospital Research Foundation, Cincinnati, OH, USA
    Blood 90:4522-31. 1997
  7. ncbi Identification of quantitative trait loci that modify the severity of hereditary spherocytosis in wan, a new mouse model of band-3 deficiency
    Luanne L Peters
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Blood 103:3233-40. 2004
  8. ncbi Localization of the twitcher (twi) mutation on mouse chromosome 12
    P D'Eustachio
    Department of Biochemistry, New York University Medical Center, New York 10016
    Mamm Genome 4:684-6. 1993
  9. ncbi The complete amino acid sequence for brain beta spectrin (beta fodrin): relationship to globin sequences
    Y Ma
    Department of Structural and Cellular Biology, University of South Alabama, School of Medicine, Mobile 36688
    Brain Res Mol Brain Res 18:87-99. 1993
  10. ncbi Cloning, chromosomal localization, and functional analysis of the murine estrogen receptor beta
    G B Tremblay
    Molecular Oncology Group, Boyal Victoria Hospital Montréal, Quebec, Canada
    Mol Endocrinol 11:353-65. 1997

Scientific Experts

  • Timothy J Koh
  • Luanne L Peters
  • W T Tse
  • Narla Mohandas
  • Christine C Krieger
  • Michael C Stankewich
  • Xiuli An
  • Sunita Patel-Hett
  • Catherine Korsgren
  • Kirian Legendre
  • Raymond F Robledo
  • Douglas G Nilson
  • J E Barker
  • N J Wandersee
  • N A Jenkins
  • N G Copeland
  • Eva C Alden
  • Hongbei Wang
  • John H Hartwig
  • Paul R Stabach
  • Anjali Nath
  • Carol D Cianci
  • Nancy J Wandersee
  • Jonathan N Thon
  • Hsin Yao Tang
  • Jon S Morrow
  • Lan Ji
  • David W Speicher
  • Joseph E Italiano
  • Dennis E Discher
  • Antonija J Begonja
  • Samuel E Lux
  • Kenneth E Sahr
  • T M Kaysser
  • Babette Gwynn
  • Polonca Küssel-Andermann
  • Saaid Safieddine
  • Steven L Ciciotte
  • Christine Petit
  • Aziz El-Amraoui
  • Diana M Gilligan
  • M L Bloom
  • Patrick G Gallagher
  • Denise E Sabatino
  • David M Bodine
  • T H Bugge
  • G B Tremblay
  • C S Birkenmeier
  • G Oliver
  • D J Gilbert
  • P D'Eustachio
  • J F Tait
  • F Khan
  • Y Ma
  • Q Xiao
  • V Clarke
  • S R Goodman
  • K W Kombrinck
  • W E Zimmer
  • K Holmbäck
  • C C Daugherty
  • J L Degen
  • R T Bronson
  • D P Witte
  • F Labrie
  • V Giguere
  • A Tremblay
  • D H Gorski
  • I MacNeil
  • G C Webb
  • S L Zipursky
  • R Wehr
  • P Gruss
  • V Hartenstein
  • B N Cheyette
  • K B Avraham
  • J Kennedy
  • D A Largaespada
  • L Cioe
  • D F LePage
  • P Laurila
  • K Walsh
  • D I Godfrey
  • C Mineo
  • M Masciantonio
  • A Zlotnik
  • B M Riederer
  • C V Patel
  • D D Bowtell
  • S M Goodman

Detail Information

Publications35

  1. ncbi Developmental expression of brain beta-spectrin isoform messenger RNAs
    W E Zimmer
    Department of Structural and Cellular Biology, College of Medicine, University of South Alabama, Mobile 36688
    Brain Res 594:75-83. 1992
    ..Thus, the data from the present study demonstrates that the expression of these two neuronal beta-spectrin isoforms is regulated at the level of mRNA expression...
  2. pmc Chromosomal location of three spectrin genes: relationship to the inherited hemolytic anemias of mouse and man
    C S Birkenmeier
    Jackson Laboratory, Bar Harbor, ME 04609
    Proc Natl Acad Sci U S A 85:8121-5. 1988
    ..The spherocytosis and jaundiced loci affect the membrane skeletal protein known as spectrin...
  3. ncbi Isolation of a cDNA encoding thymic shared antigen-1. A new member of the Ly6 family with a possible role in T cell development
    I MacNeil
    Department of Immunology, DNAX Research Institute, Palo Alto, CA 94304
    J Immunol 151:6913-23. 1993
    ..Our results suggest that TSA-1 may play a role during positive selection and the transition from CD4+CD8+ thymocytes to the mature CD4+CD8- and CD4-CD8+ subsets...
  4. pmc Cell organization, growth, and neural and cardiac development require αII-spectrin
    Michael C Stankewich
    Department of Pathology, Yale University School of Medicine, 310 Cedar St BML 150, New Haven, CT 06520, USA
    J Cell Sci 124:3956-66. 2011
    ..These data indicate that the spectrin-ankyrin scaffold is crucial in vertebrates for cell spreading, tissue patterning and organ development, particularly in the developing brain and heart, but is not required for cell viability...
  5. pmc The carboxyterminal EF domain of erythroid alpha-spectrin is necessary for optimal spectrin-actin binding
    Catherine Korsgren
    Division of Hematology Oncology, Department of Medicine, Children s Hospital Boston, Boston, MA 02115, USA
    Blood 116:2600-7. 2010
    ..1R complex. A model, based on the structure of α-actinin, suggests that the EF domain modulates the function of the ABD and that the C-terminal EF hands (EF(34)) may bind to the linker that connects the ABD to the first spectrin repeat...
  6. ncbi Growth and dissemination of Lewis lung carcinoma in plasminogen-deficient mice
    T H Bugge
    Divisions of Developmental Biology and Pathology, Children s Hospital Research Foundation, Cincinnati, OH, USA
    Blood 90:4522-31. 1997
    ....
  7. ncbi Identification of quantitative trait loci that modify the severity of hereditary spherocytosis in wan, a new mouse model of band-3 deficiency
    Luanne L Peters
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Blood 103:3233-40. 2004
    ..The peak LOD score was obtained with a marker for Spnb1 encoding erythroid beta-spectrin, an obvious candidate gene.
  8. ncbi Localization of the twitcher (twi) mutation on mouse chromosome 12
    P D'Eustachio
    Department of Biochemistry, New York University Medical Center, New York 10016
    Mamm Genome 4:684-6. 1993
  9. ncbi The complete amino acid sequence for brain beta spectrin (beta fodrin): relationship to globin sequences
    Y Ma
    Department of Structural and Cellular Biology, University of South Alabama, School of Medicine, Mobile 36688
    Brain Res Mol Brain Res 18:87-99. 1993
    ..In vitro analysis has demonstrated that heme is capable of specific attachment to brain spectrin, suggesting possible new functions in electron transfer, oxygen binding, nitric oxide binding or heme scavenging...
  10. ncbi Cloning, chromosomal localization, and functional analysis of the murine estrogen receptor beta
    G B Tremblay
    Molecular Oncology Group, Boyal Victoria Hospital Montréal, Quebec, Canada
    Mol Endocrinol 11:353-65. 1997
    ..Our results demonstrate that while ER beta shares many of the functional characteristics of ER alpha, the molecular mechanisms regulating the transcriptional activity of mER beta may be distinct from those of ER alpha...
  11. ncbi Thrombosis and secondary hemochromatosis play major roles in the pathogenesis of jaundiced and spherocytic mice, murine models for hereditary spherocytosis
    T M Kaysser
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Blood 90:4610-9. 1997
    b>Jaundiced mice, ja/ja, suffer from a severe hemolytic anemia caused by a complete deficiency of erythroid beta-spectrin...
  12. ncbi Erythroid phosphatidyl serine exposure is not predictive of thrombotic risk in mice with hemolytic anemia
    N J Wandersee
    The Jackson Laboratory, Bar Harbor, Maine 04609, USA
    Blood Cells Mol Dis 26:75-83. 2000
    ..PS exposure is elevated in all mice with HS and HE, but the percentage of RBCs with exposed PS does not correlate with thrombotic risk in these mice...
  13. ncbi A new spectrin, beta IV, has a major truncated isoform that associates with promyelocytic leukemia protein nuclear bodies and the nuclear matrix
    W T Tse
    Division of Hematology Oncology, Children s Hospital, and the Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 276:23974-85. 2001
    ..Spectrin betaIV is the first beta-spectrin associated with a subnuclear structure and may be part of a nuclear scaffold to which gene regulatory machinery binds...
  14. ncbi Cytoskeletal disruption and small heat shock protein translocation immediately after lengthening contractions
    Timothy J Koh
    School of Kinesiology, University of Illinois at Chicago, Chicago, Illinois 60608, USA
    Am J Physiol Cell Physiol 286:C713-22. 2004
    ....
  15. ncbi Mammalian homologues of the Drosophila Son of sevenless gene map to murine chromosomes 17 and 12 and to human chromosomes 2 and 14, respectively
    G C Webb
    Department of Genetics, Queen Elizabeth Hospital, Woodville, Australia
    Genomics 18:14-9. 1993
    ..3-D and their human counterparts to chromosomes 2p21-2p2 and 14q21, respectively. Neither the human nor the mouse Sos loci map close to known mutations or to regions showing consistent karyotypic abnormalities in tumor cells...
  16. ncbi Major erythrocyte membrane protein genes in EKLF-deficient mice
    Douglas G Nilson
    Hematopoiesis Section, Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA
    Exp Hematol 34:705-12. 2006
    ..The objectives of this study were to rescue EKLF-deficient embryos with mice expressing gamma-globin from beta-spectrin or ankyrin promoters and to characterize expression of the major erythrocyte membrane genes in EKLF-deficient cells...
  17. pmc Targeted deletion of alpha-adducin results in absent beta- and gamma-adducin, compensated hemolytic anemia, and lethal hydrocephalus in mice
    Raymond F Robledo
    The Jackson Laboratory, Bar Harbor, ME, USA
    Blood 112:4298-307. 2008
    ..These data indicate that adducin plays a role in RBC membrane stability and in cerebrospinal fluid homeostasis...
  18. doi alphaII-betaV spectrin bridges the plasma membrane and cortical lattice in the lateral wall of the auditory outer hair cells
    Kirian Legendre
    Institut Pasteur, Unite de Genetique et Physiologie de l Audition, 25 rue du Dr Roux, 75015 Paris, France
    J Cell Sci 121:3347-56. 2008
    ..We conclude that the cortical network involved in the sound-induced electromotility of OHCs contains alphaII-betaV spectrin, and not the conventional alphaII-betaII spectrin...
  19. pmc Cysteine shotgun-mass spectrometry (CS-MS) reveals dynamic sequence of protein structure changes within mutant and stressed cells
    Christine C Krieger
    Molecular and Cell Biophysics Lab, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 108:8269-74. 2011
    ..Shear-sensitive sites identified comprehensively here in both spectrin and ankyrin appear consistent with stress relief through forced unfolding followed by cytoskeletal disruption...
  20. pmc The spectrin-based membrane skeleton stabilizes mouse megakaryocyte membrane systems and is essential for proplatelet and platelet formation
    Sunita Patel-Hett
    Translational Medicine Division, Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Blood 118:1641-52. 2011
    ..The results of this study provide evidence for a role for spectrin in different steps of megakaryocyte development through its participation in the formation of invaginated membranes and in the maintenance of proplatelet structure...
  21. ncbi Studies of erythrocyte protoporphyrin in anemic mutant mice: use of a modified hematofluorometer for the detection of heterozygotes for hemolytic disease
    S Sassa
    Exp Hematol 6:479-87. 1978
    ....
  22. pmc Changing patterns in cytoskeletal mRNA expression and protein synthesis during murine erythropoiesis in vivo
    L L Peters
    Jackson Laboratory, Bar Harbor, ME 04609
    Proc Natl Acad Sci U S A 89:5749-53. 1992
    ....
  23. ncbi Complete nucleotide sequence of the murine erythroid beta-spectrin cDNA and tissue-specific expression in normal and jaundiced mice
    M L Bloom
    Jackson Laboratory, Bar Harbor, ME 04609
    Blood 82:2906-14. 1993
    ..The jaundiced (ja/ja) mutation causes a severe hemolytic anemia in mice and is mapped to the erythroid beta-spectrin locus (..
  24. pmc Molecular cloning of a diverged homeobox gene that is rapidly down-regulated during the G0/G1 transition in vascular smooth muscle cells
    D H Gorski
    Department of Physiology and Biophysics, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106
    Mol Cell Biol 13:3722-33. 1993
    ..The removal of serum from growing cells induced Gax expression fivefold within 24 h. These data suggest that Gax is likely to have a regulatory function in the G0-to-G1 transition of the cell cycle in vascular smooth muscle cells...
  25. ncbi Refinement of the DNA marker maps of mouse chromosome 12
    F Khan
    Department of Biochemistry, New York University Medical Center, New York 10016
    Genomics 21:128-37. 1994
    ....
  26. pmc The murine mutation jaundiced is caused by replacement of an arginine with a stop codon in the mRNA encoding the ninth repeat of beta-spectrin
    M L Bloom
    Jackson Laboratory, Bar Harbor, ME 04609
    Proc Natl Acad Sci U S A 91:10099-103. 1994
    The jaundiced, ja/ja, mouse mutant has a severe hemolytic anemia associated with a deficiency of beta-spectrin in erythrocyte ghosts. Genes for the disease phenotype and beta-spectrin colocalize on Chromosome 12...
  27. ncbi Homeobox genes and connective tissue patterning
    G Oliver
    Department of Molecular Cell Biology, Max Planck Institute of Biophysical Chemistry, Gottingen, Germany
    Development 121:693-705. 1995
    ..Six 1 and Six 2 also are expressed in skeletal and smooth muscle, respectively. These genes may participate in the patterning of the distal tendons of the limb phalanges by setting positional values along the limb axes...
  28. ncbi Identification of the molecular defect in the erythrocyte membrane skeleton of some kindreds with hereditary spherocytosis
    S R Goodman
    Blood 60:772-84. 1982
    ..It would appear therefore that the defective HS spectrin-protein-4.1 interaction in type I hereditary spherocytosis may be the primary molecular defect rather than a secondary phenomena...
  29. ncbi Spectrin deficient inherited hemolytic anemias in the mouse: characterization by spectrin synthesis and mRNA activity in reticulocytes
    D M Bodine
    Cell 37:721-9. 1984
    ..Analysis of spectrin synthesis in mice homozygous and heterozygous for several alleles of sph indicates that the sph locus is the structural gene locus for alpha spectrin. We have mapped the sph locus to mouse Chromosome 1...
  30. pmc Remarkable homology among the internal repeats of erythroid and nonerythroid spectrin
    C S Birkenmeier
    Proc Natl Acad Sci U S A 82:5671-5. 1985
    ..In this respect, the degree of homology found between them was unexpected. Our data suggest a common evolutionary origin for these two alpha-spectrins and allow some predictions concerning spectrin gene structure...
  31. ncbi Cloning and nucleotide sequence of a mouse erythrocyte beta-spectrin cDNA
    L Cioe
    Institute of Virology, University La Sapienza, Rome, Italy
    Blood 70:915-20. 1987
    ....
  32. ncbi Assignment of mouse beta-spectrin gene to chromosome 12
    P Laurila
    Somat Cell Mol Genet 13:93-7. 1987
    ..These results serve as a basis for further genetic characterization of the mouse hemolytic anemias...
  33. ncbi Murine chromosomal location of four hepatocyte-enriched transcription factors: HNF-3 alpha, HNF-3 beta, HNF-3 gamma, and HNF-4
    K B Avraham
    Mammalian Genetics Laboratory, National Cancer Institute Frederick Cancer Research and Development Center, Maryland 21702
    Genomics 13:264-8. 1992
    ....