Sparc

Summary

Gene Symbol: Sparc
Description: secreted acidic cysteine rich glycoprotein
Alias: BM-40, SPARC, basement-membrane protein 40, osteonectin, secreted protein acidic and rich in cysteine
Species: mouse

Top Publications

  1. ncbi SPARC is a VCAM-1 counter-ligand that mediates leukocyte transmigration
    Kimberly A Kelly
    Harvard Medical School, Massachusetts General Hospital, Charlestown, MA 02129, USA
    J Leukoc Biol 81:748-56. 2007
  2. doi Synergistic effects of osteonectin and brain-derived neurotrophic factor on axotomized retinal ganglion cells neurite outgrowth via the mitogen-activated protein kinase-extracellular signal-regulated kinase 1/2 pathways
    C H E Ma
    Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK
    Neuroscience 165:463-74. 2010
  3. pmc Loss of SPARC-mediated VEGFR-1 suppression after injury reveals a novel antiangiogenic activity of VEGF-A
    Miho Nozaki
    Department of Ophthalmology and Visual Sciences, University of Kentucky, Lexington, Kentucky 40536 0284, USA
    J Clin Invest 116:422-9. 2006
  4. ncbi Caveolin-1 is up-regulated in transdifferentiated lens epithelial cells but minimal in normal human and murine lenses
    Nikole Perdue
    Hope Heart Program, Benaroya Research Institute at Virginia Mason, 1201 9th Avenue, Seattle, WA 98101 2795, USA
    Exp Eye Res 83:1154-61. 2006
  5. ncbi Calcium binding domains and calcium-induced conformational transition of SPARC/BM-40/osteonectin, an extracellular glycoprotein expressed in mineralized and nonmineralized tissues
    J Engel
    Department of Biophysical Chemistry, Biozentrum, Basel, Switzerland
    Biochemistry 26:6958-65. 1987
  6. ncbi The biology of SPARC, a protein that modulates cell-matrix interactions
    T F Lane
    Department of Genetics, Howard Hughes Medical Institute, Harvard University School of Medicine, Boston, Massachusetts 02115
    FASEB J 8:163-73. 1994
  7. ncbi Two collagen-binding proteins, osteonectin and HSP47, are coordinately induced in transformed keratinocytes by heat and other stresses
    H Kudo
    Department of Cell Biology, Faculty of Medicine, Kyoto University, Japan
    Exp Cell Res 212:219-24. 1994
  8. ncbi Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts
    T Komori
    Department of Medicine III, Osaka University Medical School, Suita, Japan
    Cell 89:755-64. 1997
  9. ncbi Cloning and expression of murine SC1, a gene product homologous to SPARC
    J A Soderling
    Department of Biological Structure, University of Washington, Seattle 98195 7420, USA
    J Histochem Cytochem 45:823-35. 1997
  10. pmc Mice deficient for the secreted glycoprotein SPARC/osteonectin/BM40 develop normally but show severe age-onset cataract formation and disruption of the lens
    D T Gilmour
    Wellcome CRC Institute of Cancer and Developmental Biology and Department of Genetics, University of Cambridge, Tennis Court Rd, Cambridge CB2 3QR
    EMBO J 17:1860-70. 1998

Research Grants

Scientific Experts

Detail Information

Publications115 found, 100 shown here

  1. ncbi SPARC is a VCAM-1 counter-ligand that mediates leukocyte transmigration
    Kimberly A Kelly
    Harvard Medical School, Massachusetts General Hospital, Charlestown, MA 02129, USA
    J Leukoc Biol 81:748-56. 2007
    ..We now report a novel interaction between VCAM-1 and secreted protein acidic and rich in cysteine (SPARC), which induces actin cytoskeletal rearrangement and intercellular gaps, physiological ..
  2. doi Synergistic effects of osteonectin and brain-derived neurotrophic factor on axotomized retinal ganglion cells neurite outgrowth via the mitogen-activated protein kinase-extracellular signal-regulated kinase 1/2 pathways
    C H E Ma
    Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK
    Neuroscience 165:463-74. 2010
    Our previous study identified osteonectin (ON) in a screen of factors made by Schwann cells (SCs) which promoted peripheral and central neurons survival and neuritogenesis, however, the mechanisms of ON promoting effects are largely ..
  3. pmc Loss of SPARC-mediated VEGFR-1 suppression after injury reveals a novel antiangiogenic activity of VEGF-A
    Miho Nozaki
    Department of Ophthalmology and Visual Sciences, University of Kentucky, Lexington, Kentucky 40536 0284, USA
    J Clin Invest 116:422-9. 2006
    ..CNV before injury because VEGFR-1 activation was silenced by secreted protein, acidic and rich in cysteine (SPARC)...
  4. ncbi Caveolin-1 is up-regulated in transdifferentiated lens epithelial cells but minimal in normal human and murine lenses
    Nikole Perdue
    Hope Heart Program, Benaroya Research Institute at Virginia Mason, 1201 9th Avenue, Seattle, WA 98101 2795, USA
    Exp Eye Res 83:1154-61. 2006
    ..signaling and endocytosis, was investigated in lens epithelial cells and lens fiber cells in wild-type (wt) and SPARC-null mice and normal human donors in vivo and in vitro...
  5. ncbi Calcium binding domains and calcium-induced conformational transition of SPARC/BM-40/osteonectin, an extracellular glycoprotein expressed in mineralized and nonmineralized tissues
    J Engel
    Department of Biophysical Chemistry, Biozentrum, Basel, Switzerland
    Biochemistry 26:6958-65. 1987
    SPARC, BM-40, and osteonectin are identical or very closely related extracellular proteins of apparent Mr 43,000 (Mr 33,000 predicted from sequence)...
  6. ncbi The biology of SPARC, a protein that modulates cell-matrix interactions
    T F Lane
    Department of Genetics, Howard Hughes Medical Institute, Harvard University School of Medicine, Boston, Massachusetts 02115
    FASEB J 8:163-73. 1994
    An extracellular matrix-associated glycoprotein expressed in a variety of tissues during embryogenesis and repair, SPARC contains modular domains that can function independently to bind cells and matrix components...
  7. ncbi Two collagen-binding proteins, osteonectin and HSP47, are coordinately induced in transformed keratinocytes by heat and other stresses
    H Kudo
    Department of Cell Biology, Faculty of Medicine, Kyoto University, Japan
    Exp Cell Res 212:219-24. 1994
    ..It was sequenced and identified as a segment of mouse osteonectin (SPARC) cDNA. We found osteonectin to be heat-inducible in some cells...
  8. ncbi Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts
    T Komori
    Department of Medicine III, Osaka University Medical School, Suita, Japan
    Cell 89:755-64. 1997
    ....
  9. ncbi Cloning and expression of murine SC1, a gene product homologous to SPARC
    J A Soderling
    Department of Biological Structure, University of Washington, Seattle 98195 7420, USA
    J Histochem Cytochem 45:823-35. 1997
    A number of cDNAs (SC1, QR1, and hevin) have been shown to be similar to SPARC (secreted protein acidic and rich in cysteine), a matricellular protein that regulates cell adhesion, cell cycle, and matrix assembly and remodeling...
  10. pmc Mice deficient for the secreted glycoprotein SPARC/osteonectin/BM40 develop normally but show severe age-onset cataract formation and disruption of the lens
    D T Gilmour
    Wellcome CRC Institute of Cancer and Developmental Biology and Department of Genetics, University of Cambridge, Tennis Court Rd, Cambridge CB2 3QR
    EMBO J 17:1860-70. 1998
    SPARC (secreted protein acidic and rich in cysteine, also known as osteonectin/BM40) is a secreted Ca2+-binding glycoprotein that interacts with a range of extracellular matrix molecules, including collagen IV...
  11. ncbi SPARC (BM-40, osteonectin) inhibits the mitogenic effect of vascular endothelial growth factor on microvascular endothelial cells
    C Kupprion
    Department of Biological Structure, University of Washington School of Medicine, Seattle, Washington 98195 7420, USA
    J Biol Chem 273:29635-40. 1998
    b>SPARC (secreted protein, acidic and rich in cysteine) is a matricellular protein that modulates cell adhesion and proliferation and is thought to function in tissue remodeling and angiogenesis...
  12. ncbi Disruption of the Sparc locus in mice alters the differentiation of lenticular epithelial cells and leads to cataract formation
    J A Bassuk
    Department of Biological Structure, University of Washington School of Medicine, Seattle, WA, USA
    Exp Eye Res 68:321-31. 1999
    SPARC (secreted protein acidic and rich in cysteine) is a matricellular protein that regulates cellular adhesion and proliferation...
  13. ncbi Collagen accumulation is decreased in SPARC-null mice with bleomycin-induced pulmonary fibrosis
    T P Strandjord
    Department of Pediatrics, University of Washington, Seattle, WA 98195 6320, USA
    Am J Physiol 277:L628-35. 1999
    b>Secreted protein acidic and rich in cysteine (SPARC) has been shown to be coexpressed with type I collagen in tissues undergoing remodeling and wound repair...
  14. ncbi SPARC regulates the expression of collagen type I and transforming growth factor-beta1 in mesangial cells
    A Francki
    Department of Biological Structure, University of Washington, Seattle, Washington 98195 7420, USA
    J Biol Chem 274:32145-52. 1999
    The matricellular protein SPARC is expressed at high levels in cells that participate in tissue remodeling and is thought to regulate mesangial cell proliferation and extracellular matrix production in the kidney glomerulus in a rat ..
  15. ncbi SPARC, a matricellular glycoprotein with important biological functions
    Q Yan
    Department of Vascular Biology, Hope Heart Institute, Seattle, Washington 98122, USA
    J Histochem Cytochem 47:1495-506. 1999
    b>SPARC (secreted protein, acidic and rich in cysteine) is a unique matricellular glycoprotein that is expressed by many different types of cells and is associated with development, remodeling, cell turnover, and tissue repair...
  16. ncbi Fgfr1 and Fgfr2 have distinct differentiation- and proliferation-related roles in the developing mouse skull vault
    S Iseki
    Department of Human Anatomy and Genetics, South Parks Road, Oxford OX1 3QX, UK
    Development 126:5611-20. 1999
    ..Following up-regulation of the differentiation marker osteopontin, Fgfr1, osteonectin and alkaline phosphatase are down-regulated, suggesting that they are involved in the osteogenic ..
  17. pmc Osteopenia and decreased bone formation in osteonectin-deficient mice
    A M Delany
    Department of Research, Saint Francis Hospital and Medical Center, Hartford, Connecticut 06105, USA
    J Clin Invest 105:915-23. 2000
    ..There is evidence that the extracellular matrix glycoprotein osteonectin or secreted protein acidic and rich in cysteine (BM-40) may be important in bone remodeling...
  18. ncbi Bleomycin-induced pulmonary injury in mice deficient in SPARC
    R C Savani
    Division of Neonatology, Department of Pediatrics, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Am J Physiol Lung Cell Mol Physiol 279:L743-50. 2000
    b>SPARC (secreted protein, acidic and rich in cysteine) is a component of the matrix that appears to regulate tissue remodeling...
  19. pmc Impaired wound healing in mice deficient in a matricellular protein SPARC (osteonectin, BM-40)
    A Basu
    The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA
    BMC Cell Biol 2:15. 2001
    b>SPARC is a matricellular protein involved in cell-matrix interactions. From expression patterns at the wound site and in vitro studies, SPARC has been implicated in the control of wound healing...
  20. ncbi SPARC-null mice exhibit accelerated cutaneous wound closure
    Amy D Bradshaw
    Department of Vascular Biology, The Hope Heart Institute, Seattle, Washington 98104, USA
    J Histochem Cytochem 50:1-10. 2002
    Expression of SPARC (secreted protein acidic and rich in cysteine; osteonectin, BM-40), an extracellular matrix (ECM) associated protein, is coincident with matrix remodeling...
  21. ncbi Alterations in the lens capsule contribute to cataractogenesis in SPARC-null mice
    Qi Yan
    Department of Vascular Biology, The Hope Heart Institute, Seattle, WA 98104 2046, USA
    J Cell Sci 115:2747-56. 2002
    ..b>SPARC (secreted protein, acidic and rich in cysteine) is a matricellular glycoprotein that regulates cell-cell and cell-..
  22. pmc Compromised production of extracellular matrix in mice lacking secreted protein, acidic and rich in cysteine (SPARC) leads to a reduced foreign body reaction to implanted biomaterials
    Pauli Puolakkainen
    Department of Vascular Biology, The Hope Heart Institute, University of Washington, Seattle, Washington 98104, USA
    Am J Pathol 162:627-35. 2003
    b>SPARC (secreted protein, acidic and rich in cysteine), a matricellular glycoprotein, modulates the interaction of cells with the extracellular matrix (ECM)...
  23. pmc Enhanced growth of tumors in SPARC null mice is associated with changes in the ECM
    Rolf A Brekken
    Department of Vascular Biology, The Hope Heart Institute, Seattle, Washington 98104 2046, USA
    J Clin Invest 111:487-95. 2003
    b>SPARC, a 32-kDa glycoprotein, participates in the regulation of morphogenesis and cellular differentiation through its modulation of cell-matrix interactions...
  24. pmc SPARC-null mice exhibit increased adiposity without significant differences in overall body weight
    A D Bradshaw
    Department of Vascular Biology, Hope Heart Institute, Seattle, WA 98104, USA
    Proc Natl Acad Sci U S A 100:6045-50. 2003
    b>Secreted protein acidic and rich in cysteine/osteonectin/BM-40 (SPARC) is a matrix-associated protein that elicits changes in cell shape, inhibits cell-cycle progression, and influences the synthesis of extracellular matrix (ECM)...
  25. ncbi SPARC-null mice display abnormalities in the dermis characterized by decreased collagen fibril diameter and reduced tensile strength
    Amy D Bradshaw
    The Hope Heart Institute, Seattle, Washington 98104, USA
    J Invest Dermatol 120:949-55. 2003
    ..We present evidence that SPARC (secreted protein acidic and rich in cysteine) contributes to collagen fibril formation in the dermis...
  26. ncbi Infrared analysis of the mineral and matrix in bones of osteonectin-null mice and their wildtype controls
    Adele L Boskey
    Research Division, Hospital for Special Surgery, New York, New York 10021, USA
    J Bone Miner Res 18:1005-11. 2003
    b>Osteonectin function in bone was investigated by infrared analysis of bones from osteonectin-null (KO) and wildtype mice (four each at 11, 17, and 36 weeks)...
  27. pmc SPARC inhibits epithelial cell proliferation in part through stimulation of the transforming growth factor-beta-signaling system
    Barbara J Schiemann
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    Mol Biol Cell 14:3977-88. 2003
    Secreted protein, acidic and rich in cysteine (SPARC) is a multifunctional secreted protein that regulates cell-cell and cell-matrix interactions, leading to alterations in cell adhesion, motility, and proliferation...
  28. ncbi SPARC regulates TGF-beta1-dependent signaling in primary glomerular mesangial cells
    Aleksandar Francki
    Department of Vascular Biology, The Hope Heart Institute, Seattle, Washington 98104, USA
    J Cell Biochem 91:915-25. 2004
    b>Secreted protein acidic and rich in cysteine (SPARC), a member of the family of matricellular proteins, regulates the interaction of cells with pleiotropic factors and proteins of the extracellular matrix (ECM)...
  29. ncbi Enhanced growth of pancreatic tumors in SPARC-null mice is associated with decreased deposition of extracellular matrix and reduced tumor cell apoptosis
    Pauli A Puolakkainen
    Department of Vascular Biology, Hope Heart Institute, University of Washington, Seattle, Washington, USA
    Mol Cancer Res 2:215-24. 2004
    b>SPARC, a matricellular glycoprotein, modulates cellular interaction with the extracellular matrix (ECM). Tumor growth and metastasis occur in the context of the ECM, the levels and deposition of which are controlled in part by SPARC...
  30. ncbi Matricellular protein SPARC is translocated to the nuclei of immortalized murine lens epithelial cells
    Qi Yan
    Hope Heart Program, Benaroya Research Institute at Virginia Mason, Seattle, Washington 98104 2046, USA
    J Cell Physiol 203:286-94. 2005
    The matricellular glycoprotein, secreted protein acidic and rich in cysteine (SPARC), has complex biological activities and is important for lens epithelial cell function and regulation of cataract formation...
  31. ncbi Abnormalities in cartilage and bone development in the Apert syndrome FGFR2(+/S252W) mouse
    Yingli Wang
    Institute of Genetic Medicine, Department of Pediatrics, The Johns Hopkins University School of Medicine, 733 North Broadway, Baltimore, MD 21205, USA
    Development 132:3537-48. 2005
    ..Our results suggest that altered cartilage and bone development play a significant role in the pathogenesis of the Apert syndrome phenotype...
  32. ncbi SPARC regulates extracellular matrix organization through its modulation of integrin-linked kinase activity
    Thomas H Barker
    Hope Heart Program, Benaroya Research Institute at Virginia Mason, Seattle, Washington 98101, USA
    J Biol Chem 280:36483-93. 2005
    b>SPARC, a 32-kDa matricellular glycoprotein, mediates interactions between cells and their extracellular matrix, and targeted deletion of Sparc results in compromised extracellular matrix in mice...
  33. ncbi Absence of SPARC in murine lens epithelium leads to increased deposition of laminin-1 in lens capsule
    Qi Yan
    Hope Heart Program, Benaroya Research Institute at Virginia Mason, Seattle, Washington 98101 2795, USA
    Invest Ophthalmol Vis Sci 46:4652-60. 2005
    To investigate the role of SPARC in the regulation of the expression and deposition of extracellular matrix (ECM) proteins in the lens capsule.
  34. ncbi Splenic and immune alterations of the Sparc-null mouse accompany a lack of immune response
    S A Rempel
    Department of Neurosurgery, Barbara Jane Levy Laboratory of Molecular Neuro Oncology, Hermelin Brain Tumor Center, Henry Ford Hospital, Detroit, MI, USA
    Genes Immun 8:262-74. 2007
    b>Sparc-null mice have been used as models to assess tumor-host immune cell interactions. However, it is not known if they have a competent immune system. In this study, the immune systems of Sparc wild-type and null mice were compared...
  35. pmc Secreted protein acidic and rich in cysteine deficiency ameliorates renal inflammation and fibrosis in angiotensin hypertension
    Matthew J Socha
    Vascular Biology Center, Medical College of Georgia, 1459 Laney Walker Blvd, CB 3306, Augusta, GA 30912, USA
    Am J Pathol 171:1104-12. 2007
    The matricellular protein secreted protein acidic and rich in cysteine (SPARC) modulates cell adhesion, proliferation, matrix deposition, and tissue remodeling...
  36. pmc Forced expression of MMP9 rescues the loss of angiogenesis and abrogates metastasis of pancreatic tumors triggered by the absence of host SPARC
    Shanna Arnold
    Hamon Center for Therapeutic Oncology Research, UT Southwestern Medical Center, 6000 Harry Hines Blvd, Dallas, TX 75390 8593, USA
    Exp Biol Med (Maywood) 233:860-73. 2008
    ..These features are regulated in part by MMP9 and SPARC. To explore the interaction of SPARC and MMP9 in cancer, we first established orthotopic pancreatic tumors in ..
  37. pmc The copper binding domain of SPARC mediates cell survival in vitro via interaction with integrin beta1 and activation of integrin-linked kinase
    Matt S Weaver
    Hope Heart Program, Benaroya Research Institute at Virginia Mason, Seattle, Washington 98101 2795, USA
    J Biol Chem 283:22826-37. 2008
    b>Secreted protein acidic and rich in cysteine (SPARC) is important for the normal growth and maintenance of the murine lens...
  38. pmc Absence of SPARC results in increased cardiac rupture and dysfunction after acute myocardial infarction
    Mark W M Schellings
    Center for Heart Failure Research, Cardiovascular Research Institute Maastricht, University Hospital Maastricht, 6229 HX Maastricht, The Netherlands
    J Exp Med 206:113-23. 2009
    The matricellular protein SPARC (secreted protein, acidic and rich in cysteine, also known as osteonectin) mediates cell-matrix interactions during wound healing and regulates the production and/or assembly of the extracellular matrix (..
  39. pmc Pressure overload-induced alterations in fibrillar collagen content and myocardial diastolic function: role of secreted protein acidic and rich in cysteine (SPARC) in post-synthetic procollagen processing
    Amy D Bradshaw
    Gazes Cardiac Research Institute, Division of Cardiology, Department of Medicine, RHJ Department of Veterans Affairs Medical Center, Medical University of South Carolina, Charleston, SC 29425, USA
    Circulation 119:269-80. 2009
    ..We further hypothesized that secreted protein acidic and rich in cysteine (SPARC) plays a key role in post-synthetic procollagen processing in normal and pressure-..
  40. pmc Lack of host SPARC enhances vascular function and tumor spread in an orthotopic murine model of pancreatic carcinoma
    Shanna A Arnold
    Hamon Center for Therapeutic Oncology Research, Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Dis Model Mech 3:57-72. 2010
    Utilizing subcutaneous tumor models, we previously validated SPARC (secreted protein acidic and rich in cysteine) as a key component of the stromal response, where it regulated tumor size, angiogenesis and extracellular matrix deposition...
  41. pmc Age-dependent alterations in fibrillar collagen content and myocardial diastolic function: role of SPARC in post-synthetic procollagen processing
    Amy D Bradshaw
    Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA
    Am J Physiol Heart Circ Physiol 298:H614-22. 2010
    ..We further hypothesized that secreted protein acidic and rich in cysteine (SPARC) plays a key role in the changes in post-synthetic procollagen processing that occur in ..
  42. pmc The role of MMP-9 in the anti-angiogenic effect of secreted protein acidic and rich in cysteine
    P Bhoopathi
    Program of Cancer Biology, Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine at Peoria, One Illini Drive, Peoria, IL 61605, USA
    Br J Cancer 102:530-40. 2010
    b>Secreted protein acidic and rich in cysteine (SPARC), a matricellular glycoprotein, modulates cellular interaction with the extracellular matrix and is capable of altering the growth of various cancers...
  43. doi Interaction of Pax6 with SPARC and p53 in brain of mice indicates Smad3 dependent auto-regulation
    Ratnakar Tripathi
    Department of Zoology, Banaras Hindu University, Varanasi 221005, India
    J Mol Neurosci 41:397-403. 2010
    ..Pax6 is known to be a nuclear protein, it is presumed that it may interact with matricelluar proteins like SPARC during transport and processing of Pax6...
  44. pmc Attenuation of fibrosis in vitro and in vivo with SPARC siRNA
    Jiu Cun Wang
    State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, 220 Handan Road, Shanghai 200433, PR China
    Arthritis Res Ther 12:R60. 2010
    b>SPARC is a matricellular protein, which, along with other extracellular matrix components including collagens, is commonly over-expressed in fibrotic diseases...
  45. pmc SPARC/osteonectin functions to maintain homeostasis of the collagenous extracellular matrix in the periodontal ligament
    Jessica M Trombetta
    Department of Craniofacial Biology, Medical University of South Carolina, Charleston, SC 29425, USA
    J Histochem Cytochem 58:871-9. 2010
    Expression of secreted protein acidic and rich in cysteine (SPARC)/osteonectin, a collagen-binding matricellular protein, is frequently associated with tissues with high rates of collagen turnover, such as bone...
  46. pmc Behavioral signs of chronic back pain in the SPARC-null mouse
    Magali Millecamps
    Alan Edwards Centre for Research on Pain, McGill University, Montreal, Quebec, Canada
    Spine (Phila Pa 1976) 36:95-102. 2011
    Secreted Protein, Acidic, and Rich in Cysteine (SPARC)-null mice were examined for behavioral signs of chronic low back and/or radicular pain.
  47. pmc SPARC regulates collagen interaction with cardiac fibroblast cell surfaces
    Brett S Harris
    Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina, and Ralph H Johnson Department of Veteran s Affairs Health Center, Charleston, South Carolina, USA
    Am J Physiol Heart Circ Physiol 301:H841-7. 2011
    Cardiac tissue from mice that do not express secreted protein acidic and rich in cysteine (SPARC) have reduced amounts of insoluble collagen content at baseline and in response to pressure overload hypertrophy compared with wild-type (WT) ..
  48. pmc SPARC promotes pericyte recruitment via inhibition of endoglin-dependent TGF-β1 activity
    Lee B Rivera
    Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    J Cell Biol 193:1305-19. 2011
    Pericytes migrate to nascent vessels and promote vessel stability. Recently, we reported that secreted protein acidic and rich in cysteine (SPARC)-deficient mice exhibited decreased pericyte-associated vessels in an orthotopic model of ..
  49. pmc Rapid-throughput skeletal phenotyping of 100 knockout mice identifies 9 new genes that determine bone strength
    J H Duncan Bassett
    Molecular Endocrinology Group, Department of Medicine, Imperial College London, London, United Kingdom
    PLoS Genet 8:e1002858. 2012
    ..Application of the approach to diseases affecting other physiological systems will help to realize the full potential of the International Mouse Phenotyping Consortium...
  50. ncbi In situ hybridization studies suggest a role for the basic region-leucine zipper protein hXBP-1 in exocrine gland and skeletal development during mouse embryogenesis
    I M Clauss
    Department of Cancer Biology, Harvard School of Public Health, Boston, Massachusetts 02115
    Dev Dyn 197:146-56. 1993
    ..observations suggest that hXBP-1 may play a role in regulating the expression of tissue specific genes (TIMP, osteonectin, osteopontin, osteocalcin) expressed in osteoblasts...
  51. ncbi SPARC deficiency leads to early-onset cataractogenesis
    K Norose
    The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    Invest Ophthalmol Vis Sci 39:2674-80. 1998
    To determine the role of SPARC (secreted protein, acidic, and rich in cysteine) in cataractogenesis by examining mice deficient in a matricellular protein SPARC.
  52. ncbi Lenses of SPARC-null mice exhibit an abnormal cell surface-basement membrane interface
    K Norose
    Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    Exp Eye Res 71:295-307. 2000
    SPARC (secreted protein acidic and rich in cysteine) is a matricellular protein involved in cell-matrix interactions...
  53. ncbi Targeted deletion of the SPARC gene accelerates disc degeneration in the aging mouse
    Helen E Gruber
    Department of Orthopaedic Surgery, Carolinas Medical Center, PO Box 32861, Charlotte, NC 28232, USA
    J Histochem Cytochem 53:1131-8. 2005
    b>SPARC (secreted protein, acidic, and rich in cysteine) is a matricellular protein that is present in the intervertebral disc; in man, levels of SPARC decrease with aging and degeneration...
  54. ncbi Accelerated dendritic-cell migration and T-cell priming in SPARC-deficient mice
    Sabina Sangaletti
    Immunotherapy and Gene Therapy Unit, Department of Experimental Oncology, Istituto Nazionale per lo Studio e la Cura dei Tumori, 20133 Milano, Italy
    J Cell Sci 118:3685-94. 2005
    ..The matricellular protein SPARC (secreted protein, acidic and rich in cysteine), which is induced during inflammation and tissue repair, organizes ..
  55. ncbi Matricellular hevin regulates decorin production and collagen assembly
    Millicent M Sullivan
    Hope Heart Program, Benaroya Research Institute at Virginia Mason, Seattle, Washington 98101, USA
    J Biol Chem 281:27621-32. 2006
    Matricellular proteins such as SPARC, thrombospondin 1 and 2, and tenascin C and X subserve important functions in extracellular matrix synthesis and cellular adhesion to extracellular matrix...
  56. ncbi Increased Notch 1 expression and attenuated stimulatory G protein coupling to adenylyl cyclase in osteonectin-null osteoblasts
    Catherine B Kessler
    Center for Molecular Medicine, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, Connecticut 06030, USA
    Endocrinology 148:1666-74. 2007
    Osteonectin, or secreted protein acidic and rich in cysteine, is one of the most abundant noncollagen matrix components in bone...
  57. ncbi SPARC regulates processing of procollagen I and collagen fibrillogenesis in dermal fibroblasts
    Tyler J Rentz
    Department of Medicine, Medical University of South Carolina, Charleston, SC 29412, USA
    J Biol Chem 282:22062-71. 2007
    ..SPARC (secreted protein acidic and rich in cysteine) is a counter-adhesive protein that binds collagens...
  58. ncbi Common deleted genes in the 5q- syndrome: thrombocytopenia and reduced erythroid colony formation in SPARC null mice
    S Lehmann
    Division of Hematology Oncology, Cedars Sinai Medical Center, School of Medicine, University of California Los Angeles, Los Angeles, CA, USA
    Leukemia 21:1931-6. 2007
    ..receptor-beta (PDGFRB; 73%), Nef-associated factor 1 (TNIP1; 72%), secreted protein, acidic and rich in cysteine (SPARC; 71%), annexin VI (ANAX6; 69%), NSDT (66%) and TIGD (60%)...
  59. pmc Osteopenia in Sparc (osteonectin)-deficient mice: characterization of phenotypic determinants of femoral strength and changes in gene expression
    Fiona C Mansergh
    School of Biosciences, Cardiff University, Cardiff
    Physiol Genomics 32:64-73. 2007
    b>Sparc null mutants have been generated independently via targeted mutations in exons 4 and 6. Previous studies have identified low-turnover osteopenia in the 129Sv/C57BL/6 exon 4 knockout...
  60. ncbi Type I collagen-deficient Mov-13 mice do not retain SPARC in the extracellular matrix: implications for fibroblast function
    M L Iruela-Arispe
    Department of Biological Structure, University of Washington School of Medicine, Seattle 98195, USA
    Dev Dyn 207:171-83. 1996
    ..g., fibronectin, secreted protein acidic and rich in cysteine (SPARC), decorin, and transforming growth factor-beta...
  61. ncbi SPARC regulates cell cycle progression in mesangial cells via its inhibition of IGF-dependent signaling
    Aleksandar Francki
    Department of Vascular Biology, The Hope Heart Institute, Seattle, Washington 98104, USA
    J Cell Biochem 88:802-11. 2003
    ..b>Secreted protein acidic and rich in cysteine (SPARC), a matricellular protein, has been shown to modulate the interaction of cells with ..
  62. pmc Activation of p38 MAPK pathway in the skull abnormalities of Apert syndrome Fgfr2(+P253R) mice
    Yingli Wang
    Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, New York, USA
    BMC Dev Biol 10:22. 2010
    ..We previously reported an inbred transgenic mouse model with the Fgfr2 +/S252W mutation on the C57BL/6J background for Apert syndrome. Here we present a mouse model for the Fgfr2+/P253R mutation...
  63. pmc SPARC deficiency results in improved surgical survival in a novel mouse model of glaucoma filtration surgery
    Li Fong Seet
    Ocular Wound Healing and Therapeutics Group, Singapore Eye Research Institute, Singapore, Singapore
    PLoS ONE 5:e9415. 2010
    ..b>SPARC (secreted protein, acidic and rich in cysteine) is a matricellular protein involved in extracellular matrix (ECM) ..
  64. pmc Augmented osteolysis in SPARC-deficient mice with bone-residing prostate cancer
    N Patrick McCabe
    Department of Molecular Cardiology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Neoplasia 13:31-9. 2011
    ..This study explores the role of the bone stromal matricellular protein SPARC (osteonectin/BM-40) in the progression of bone metastatic prostate cancer...
  65. doi The matricellular protein SPARC supports follicular dendritic cell networking toward Th17 responses
    Silvia Piconese
    Molecular Immunology Unit, Department of Experimental Oncology and Molecular Medicine, AmadeoLab, Fondazione IRCCS Istituto Nazionale Tumori, Via Amadeo 42, 20133 Milan, Italy
    J Autoimmun 37:300-10. 2011
    ..Here we show that murine and human reactive lymph nodes express SPARC in the germinal centres...
  66. doi SPARC promotes the development of erythroid progenitors
    Zhen Luo
    Department of Adult Stem Cells, Institute of Reproduction and Stem Cell Engineering, Central South University, Changsha, China
    Exp Hematol 40:828-36. 2012
    b>Secreted protein acidic and rich in cysteine (SPARC) is a well-recognized regulator that affects cell proliferation, differentiation, and survival. Here, we investigated the impact of SPARC on erythropoiesis...
  67. pmc Age and SPARC change the extracellular matrix composition of the left ventricle
    Lisandra E de Castro Brás
    Mississippi Center for Heart Research, University of Mississippi Medical Center UMMC, Jackson, MS 39216, USA San Antonio Cardiovascular Proteomics Center, University of Texas Health Science Center at San Antonio UTHSCA, San Antonio, TX 78229, USA
    Biomed Res Int 2014:810562. 2014
    b>Secreted protein acidic and rich in cysteine (SPARC), a collagen-binding matricellular protein, has been implicated in procollagen processing and deposition...
  68. pmc Secreted protein acidic and rich in cysteine facilitates age-related cardiac inflammation and macrophage M1 polarization
    Hiroe Toba
    Mississippi Center for Heart Research and San Antonio Cardiovascular Proteomics Center, Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi Department of Clinical Pharmacology, Division of Pathological Sciences, Kyoto Pharmaceutical University, Kyoto, Japan
    Am J Physiol Cell Physiol 308:C972-82. 2015
    To investigate the role of secreted protein acidic and rich in cysteine (SPARC) in age-related cardiac inflammation, we studied six groups of mice: young (3-5 mo old), middle-aged (10-12 mo old), and old (18-29 mo old) C57BL/6 wild-type (..
  69. pmc Lack of the matricellular protein SPARC (secreted protein, acidic and rich in cysteine) attenuates liver fibrogenesis in mice
    Catalina Atorrasagasti
    Gene Therapy Laboratory, School of Medicine, Austral University, Derqui Pilar, Buenos Aires, Argentina
    PLoS ONE 8:e54962. 2013
    Secreted Protein, Acidic and Rich in Cysteine (SPARC) is a matricellular protein involved in many biological processes and found over-expressed in cirrhotic livers...
  70. ncbi A family of type I keratin genes and the homeobox-2 gene complex are closely linked to the rex locus on mouse chromosome 11
    J H Nadeau
    Jackson Laboratory, Bar Harbor, Maine 04609
    Genomics 5:454-62. 1989
    ....
  71. pmc The Hox-2 homeo box gene complex on mouse chromosome 11 is closely linked to Re
    C P Hart
    Department of Biology, Yale University, New Haven, Connecticut 06511
    Genetics 118:319-27. 1988
    ..The results place the Hoax-2 locus approximately 1 cM from the rex (Re) locus on mouse chromosome 11...
  72. ncbi mgl-1, a mouse homologue of the Drosophila tumor-suppressor gene l(2)gl, maps to chromosome 11
    K Kuwabara
    First Department of Biochemistry, Niigata University School of Medicine, Japan
    Genomics 20:337-8. 1994
  73. ncbi Genetic mapping of members of the polyubiquitin gene subfamily coding for UbB
    G C Voss
    Developmental Biology Unit, University of Bielefeld, Germany
    Mamm Genome 7:169. 1996
  74. ncbi Expression of the matricellular protein SPARC in murine lens: SPARC is necessary for the structural integrity of the capsular basement membrane
    Qi Yan
    Department of Vascular Biology, The Hope Heart Institute, Seattle, Washington 98104, USA
    J Histochem Cytochem 51:503-11. 2003
    b>SPARC (Secreted Protein, Acidic and Rich in Cysteine) is a matricellular glycoprotein that modulates cell proliferation, adhesion, migration, and extracellular matrix (ECM) production...
  75. ncbi SPARC-thrombospondin-2-double-null mice exhibit enhanced cutaneous wound healing and increased fibrovascular invasion of subcutaneous polyvinyl alcohol sponges
    Pauli A Puolakkainen
    Hope Heart Program, Benaroya Research Institute at Virginia Mason, 1201 9th Ave, Seattle, WA 98101, USA
    J Histochem Cytochem 53:571-81. 2005
    b>Secreted protein acidic and rich in cysteine (SPARC) and thrombospondin-2 (TSP-2) are structurally unrelated matricellular proteins that have important roles in cell-extracellular matrix (ECM) interactions and tissue repair...
  76. ncbi Parietal endoderm secreted SPARC promotes early cardiomyogenesis in vitro
    Martina Stary
    Max F Perutz Laboratories, University Institutes at the Vienna Biocenter, Department of Medical Biochemistry, Division of Molecular Cell Biology, Medical University of Vienna, Dr Bohrgasse 9, A1030 Vienna, Austria
    Exp Cell Res 310:331-43. 2005
    ..Here, we demonstrate that Secreted Protein, Acidic, Rich in Cysteine, SPARC, predominantly secreted by mesenchymal parietal endoderm specifically promotes early myocardial cell ..
  77. ncbi Development of a deer mouse whole-genome radiation hybrid panel and comparative mapping of Mus chromosome 11 loci
    Clifton M Ramsdell
    Peromyscus Genetic Stock Center, Department of Biological Sciences, University of South Carolina, 700 Sumter Street, Columbia, South Carolina 29208, USA
    Mamm Genome 17:37-48. 2006
    ..Furthermore, this separate linkage group is likely to reside in a chromosomal region of inversion polymorphism between P. maniculatus and P. polionotus...
  78. ncbi Proteomic analysis of soluble factors secreted by limbal fibroblasts
    Shigeto Shimmura
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Mol Vis 12:478-84. 2006
    ..To identify soluble factors selectively secreted by limbal fibroblasts as possible regulators of limbal basal epithelium...
  79. pmc The role of TGF-beta signaling in regulating chondrogenesis and osteogenesis during mandibular development
    Kyoko Oka
    Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, 2250 Alcazar Street, CSA 103, Los Angeles, CA 90033, USA
    Dev Biol 303:391-404. 2007
    ..Collectively, our data suggest that there are differential signal cascades in response to TGF-beta to control chondrogenesis and osteogenesis during mandibular development...
  80. pmc Deficiency of SPARC suppresses intestinal tumorigenesis in APCMin/+ mice
    Owen J Sansom
    Beatson Institute of Cancer Research, Glasgow, Scotland, UK
    Gut 56:1410-4. 2007
    b>SPARC (secreted protein acidic, rich in cysteine) is a matricellular protein that has been found to be activated in a number of human cancers. More recently, it has been shown to be upregulated in human gastric and colorectal cancer...
  81. pmc Contrasting roles of SPARC-related granuloma in bacterial containment and in the induction of anti-Salmonella typhimurium immunity
    Gianluca Rotta
    Department of Experimental Oncology, European Institute of Oncology, 20141 Milan, Italy
    J Exp Med 205:657-67. 2008
    ..We studied the function of the matricellular protein secreted protein, acidic and rich in cysteine (SPARC/osteonectin) in the dissemination of locally injected Salmonella typhimurium and in the subsequent immune response...
  82. doi SPARC is expressed by macroglia and microglia in the developing and mature nervous system
    Adele J Vincent
    Department of Zoology, University of British Columbia, Vancouver, Canada
    Dev Dyn 237:1449-62. 2008
    b>SPARC (secreted protein, acidic and rich in cysteine) is a matricellular protein that is highly expressed during development, tissue remodeling, and repair...
  83. pmc Accentuated osteoclastic response to parathyroid hormone undermines bone mass acquisition in osteonectin-null mice
    Luciene Machado do Reis
    University of Sao Paulo, Sao Paulo, Brazil
    Bone 43:264-73. 2008
    ..proteins play a unique role in the skeleton as regulators of bone remodeling, and the matricellular protein osteonectin (SPARC, BM-40) is the most abundant non-collagenous protein in bone...
  84. doi Macrophage-derived SPARC bridges tumor cell-extracellular matrix interactions toward metastasis
    Sabina Sangaletti
    Department of Experimental Oncology, Immunotherapy and Gene Therapy Unit, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico, Istituto Nazionale dei Tumori, Universita degli Studi di Milano, Milan, Italy
    Cancer Res 68:9050-9. 2008
    ..b>Secreted protein acidic and rich in cysteine (SPARC) is a matricellular protein known to regulate extracellular matrix (ECM) deposition and ..
  85. doi Recombinant mouse SPARC promotes parietal endoderm differentiation and cardiomyogenesis in embryoid bodies
    Christopher Hrabchak
    Department of Chemical Engineering and Applied Chemistry, University of Toronto, 200 College Street, Toronto, ON M5S, Canada
    Biochem Cell Biol 86:487-99. 2008
    ..Cardiomyogenesis in embryoid bodies was recently demonstrated to be promoted by PYS-2-derived native SPARC (secreted protein, acidic and rich in cysteine), whose expression is upregulated in parietal endoderm at the onset ..
  86. pmc SPARC accelerates disease progression in experimental crescentic glomerulonephritis
    Amy N Sussman
    Department of Medicine, Division of Nephrology, University of Washington School of Medicine, Seattle, Washington 98195, USA
    Am J Pathol 174:1827-36. 2009
    ..b>Secreted protein acidic and rich in cysteine (SPARC), a matricellular protein with counteradhesive properties, is normally expressed at low ..
  87. pmc The first draft of the endostatin interaction network
    Clément Faye
    Institut de Biologie et Chimie des Proteines, UMR 5086 CNRS, University Lyon 1, IFR 128 Biosciences Gerland Lyon Sud, 7 passage du Vercors, 69367 Lyon Cedex 07, France
    J Biol Chem 284:22041-7. 2009
    ..include glycosaminoglycans (chondroitin and dermatan sulfate), matricellular proteins (thrombospondin-1 and SPARC), collagens (I, IV, and VI), the amyloid peptide Abeta-(1-42), and transglutaminase-2...
  88. doi Identification of SPARC as a candidate target antigen for immunotherapy of various cancers
    Mitsuhiro Inoue
    Department of Immunogenetics, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
    Int J Cancer 127:1393-403. 2010
    ..A genome-wide cDNA microarray analysis identified that secreted protein acidic and rich in cysteine (SPARC) gene is overexpressed in the gastric, pancreatic and colorectal cancer tissues but not ..
  89. doi SPARC interacts with AMPK and regulates GLUT4 expression
    Haiyan Song
    Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Harbin Medical University, XueFu Road 246, Harbin 150080, China
    Biochem Biophys Res Commun 396:961-6. 2010
    ..We show that secreted protein acidic and rich in cysteine (SPARC) is an AMPK-interacting protein, and the two proteins enhance each other...
  90. doi Inactivation of SPARC enhances high-fat diet-induced obesity in mice
    Jing Nie
    Benaroya Research Institute at Virginia Mason, Seattle, Washington 98101, USA
    Connect Tissue Res 52:99-108. 2011
    Secreted protein, acidic and rich in cysteine (SPARC), a matricellular protein, modulates extracellular matrix assembly and turnover in many physiological processes. SPARC-null mice exhibit an increased accumulation of adipose tissue...
  91. pmc Expression in SPARC-null mice of collagen type I lacking the globular domain of the α1(I) N-propeptide results in abdominal hernias and loss of dermal collagen
    Lauren Card
    Gazes Cardiac Research Institute, Division of Cardiology, Dept of Medicine, Medical University of South Carolina, Charleston, SC 29425, United States
    Matrix Biol 29:559-64. 2010
    ..To determine whether the N-propeptide contributed to decreased collagen content in SPARC-null mice, mice carrying a deletion of exon 2, which encodes the globular domain of the N-propeptide of collagen I,..
  92. pmc LPS induces greater bone and PDL loss in SPARC-null mice
    J Trombetta-Esilva
    Department of Craniofacial Biology and Center for Oral Health Research, Medical University of South Carolina, Charleston, SC, USA
    J Dent Res 90:477-82. 2011
    ..Collagen I is the primary component of bone and PDL extracellular matrix. SPARC/Osteonectin (SP/ON) is implicated in the regulation of collagen content in healthy PDL...
  93. pmc Mutations in the RNA granule component TDRD7 cause cataract and glaucoma
    Salil A Lachke
    Division of Genetics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Science 331:1571-6. 2011
    ..These findings demonstrate a role for RGs in vertebrate organogenesis...
  94. ncbi The locus Om, responsible for the DDK syndrome, maps close to Sigje on mouse chromosome 11
    P A Baldacci
    Unite de Genetique des Mammiferes, Institut Pasteur, Paris, France
    Mamm Genome 2:100-5. 1992
    ..Our results indicate that a single locus, Om, is responsible for the DDK syndrome and is located on Chromosome (Chr) 11, very close to the Sigje locus...
  95. ncbi Chromosomal localization of zinc finger protein genes in man and mouse
    A Ashworth
    Institute of Cancer Research, Chester Beatty Laboratories, London, United Kingdom
    Genomics 4:323-7. 1989
    ..In humans ZFP3 has been localized to chromosome 17p12-17pter and thus is part of the conserved linkage group between this chromosome and the distal half of mouse chromosome 11...
  96. ncbi Chromosomal localization of the mouse homolog of the Huntington's disease linked G8 (D4S10) marker
    S V Cheng
    Neurogenetics Laboratory, Massachusetts General Hospital, Boston
    DNA 6:401-7. 1987
    ..The mouse locus was mapped to the central region of chromosome 11 at 1 centiMorgan from the SPARC gene, a locus whose human counterpart is on human chromosome 5.
  97. ncbi Expression of SPARC/osteonectin transcript in murine embryos and gonads
    C C Howe
    Wistar Institute, Philadelphia, Pennsylvania 19104
    Differentiation 37:20-5. 1988
    ..Nucleotide-sequence analysis revealed extensive homology between this clone and SPARC/osteonectin cDNA cloned from mouse parietal endoderm and bovine bone cells...
  98. ncbi Cloning and complete amino acid sequences of human and murine basement membrane protein BM-40 (SPARC, osteonectin)
    B Lankat-Buttgereit
    Dermatologische Klinik der Universität München, FRG
    FEBS Lett 236:352-6. 1988
    ..The sequences showed 92% identity and were also essentially identical to those of bone osteonectin and of the parietal endoderm protein SPARC...
  99. ncbi Localization of sequences related to the human RAD6 DNA repair gene on mouse chromosomes 11 and 13
    M L Roller
    Department of Human Genetics, University of Michigan Medical School, Ann Arbor 48109 0618, USA
    Mamm Genome 6:305-6. 1995
  100. ncbi Comparative mapping of the imprinted U2afbpL gene on mouse chromosome 11 and human chromosome 5
    I Kalcheva
    Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffallo, NY 14263
    Cytogenet Cell Genet 68:19-24. 1995
    ..The location of the human homologue has been determined using both somatic cell hybrid genetic analysis and fluorescence in situ hybridization. These analyses have mapped the human locus U2AFBPL to human chromosome 5q23-->q31...
  101. ncbi Expression of the gene encoding the extracellular matrix glycoprotein SPARC in the developing and adult mouse brain
    D B Mendis
    Department of Zoology, University of Toronto, Ont, Canada
    Brain Res Mol Brain Res 24:11-9. 1994
    The pattern of expression of the SPARC gene was examined during postnatal development of the mouse brain using in situ hybridization...

Research Grants11

  1. SPARC Modulates Extracellular Matrix Dynamics in Skin
    AMY BRADSHAW; Fiscal Year: 2004
    This research proposal addresses the function of SPARC (secreted protein acidic and rich in cysteine) in the maintenance and repair of collagenous matrices in the skin...
  2. Post-Synthetic Procollagen Processing in Load-Induced Left Ventricular Remodeling
    AMY DODD BRADSHAW; Fiscal Year: 2010
    ..in vitro, using murine primary cardiac fibroblast culture studies, whether a change in SPARC (Secreted Protein Acidic and Rich in Cysteine) expression or procollagen binding results in an isolated change in procollagen processing and ..
  3. Micro-computed tomography system (Micro-CT)
    Adele Boskey; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  4. AGING AND ENDOTHELIAL CELL FUNCTION
    May Reed; Fiscal Year: 2009
    ..The elucidation of mechanisms that regulate MMP activity in aged cells and tissues will assist the development of therapies to improve wound repair and revascularization of ischemic organs. ..
  5. OSTEOPOROSIS, COLLAGEN CROSS-LINKS & BIOMECHANICS
    Adele Boskey; Fiscal Year: 2003
    ..The proposed studies will be based on histology, FTIR Imaging (FTIRI), biomechanical, and biochemical techniques and represent a novel approach to evaluating the organic matrix inosteoporosis. ..
  6. Lens Basement Membrane in SPARC-Null Cataractogenesis
    Qi Yan; Fiscal Year: 2005
    SPARC (secreted protein acidic and rich in cysteine), also termed osteonectin and BM-40, is a matricellular glycoprotein which has been shown to regulate cell functions such as cell cycle, cell shape change, migration, adhesion, gene ..
  7. Aging and the Microvasculature
    May Reed; Fiscal Year: 2006
    ..The results will define the key points of deficient microvascular growth in the aged and also develop the microvessel sprout model into a highly useful tool for studies of vascular growth in general. ..
  8. THE ROLE OF SPARC IN GLIOMA INVASION
    Sandra Rempel; Fiscal Year: 2007
    ..b>Secreted protein acidic and rich in cysteine (SPARC) is highly expressed in gliomas...
  9. Stretch-Induced Podocyte Injury
    Raghu Durvasula; Fiscal Year: 2007
    ..abstract_text> ..
  10. IN VITRO INITIATION OF BIOLOGICAL CALCIFICATION
    Adele Boskey; Fiscal Year: 2009
    ....
  11. MECHANISM OF HARD TISSUE MINERALIZATION
    Adele L Boskey; Fiscal Year: 2010
    ..Aim 3: To determine whether DSPP and BGN interact synergistically during the collagen-based in vitro mineralization process using in vitro and in situ analyses. ..