Sox9

Summary

Gene Symbol: Sox9
Description: SRY (sex determining region Y)-box 9
Alias: 2010306G03Rik, AV220920, mKIAA4243, transcription factor SOX-9, SRY-box containing gene 9
Species: mouse

Top Publications

  1. pmc Inactivation of Dicer1 in Steroidogenic factor 1-positive cells reveals tissue-specific requirement for Dicer1 in adrenal, testis, and ovary
    Chen Che J Huang
    Department of Veterinary Biosciences, University of Illinois, Urbana, IL, USA
    BMC Dev Biol 10:66. 2010
  2. ncbi Sox9 is required for cartilage formation
    W Bi
    Department of Molecular Genetics, The University of Texas, M D Anderson Cancer Center, Houston 77030, USA
    Nat Genet 22:85-9. 1999
  3. doi Sex determination involves synergistic action of SRY and SF1 on a specific Sox9 enhancer
    Ryohei Sekido
    Division of Developmental Genetics, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Nature 453:930-4. 2008
  4. ncbi Autosomal sex reversal and campomelic dysplasia are caused by mutations in and around the SRY-related gene SOX9
    T Wagner
    Institute of Human Genetics, University of Freiburg, Federal Republic of Germany
    Cell 79:1111-20. 1994
  5. ncbi The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation
    Kazuhisa Nakashima
    Department of Molecular Genetics and Program in Genes and Development, M D Anderson Cancer Center, University of Texas, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Cell 108:17-29. 2002
  6. pmc Fgf9 and Wnt4 act as antagonistic signals to regulate mammalian sex determination
    Yuna Kim
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina, USA
    PLoS Biol 4:e187. 2006
  7. pmc Stabilization of beta-catenin in XY gonads causes male-to-female sex-reversal
    Danielle M Maatouk
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Hum Mol Genet 17:2949-55. 2008
  8. pmc SOX9 is an intestine crypt transcription factor, is regulated by the Wnt pathway, and represses the CDX2 and MUC2 genes
    Philippe Blache
    Institut de Genetique Humaine, CNRS UPR1142, 141 rue de la Cardonille, 34396 Montpellier, Cedex 5, France
    J Cell Biol 166:37-47. 2004
  9. ncbi SOX9 is up-regulated by the transient expression of SRY specifically in Sertoli cell precursors
    Ryohei Sekido
    Division of Developmental Genetics, MRC National Institute for Medical Research, London NW7 1AA, UK
    Dev Biol 274:271-9. 2004
  10. doi R-spondin1 plays an essential role in ovarian development through positively regulating Wnt-4 signaling
    Kazuma Tomizuka
    Discovery Research Laboratories, Research Division, Kirin Pharma Co, Ltd, Takasaki shi, Gunma, 370 1295, Japan
    Hum Mol Genet 17:1278-91. 2008

Research Grants

  1. Excess TGF beta in neonatal lung injury and repair
    David Warburton; Fiscal Year: 2004
  2. The role of HNF4 in gastrointestinal development
    Michele Battle; Fiscal Year: 2006
  3. Lung epithelial and vascular morphogenesis
    David Warburton; Fiscal Year: 2006
  4. AUTOCRINE/PARACRINE GROWTH FACTORS & LUNG MORPHOGENESIS
    David Warburton; Fiscal Year: 2009
  5. ROLES OF SOX C GENES IN SKELETOGENESIS
    VERONIQUE M LEFEBVRE; Fiscal Year: 2010
  6. DEVELOPMENTAL TYPE II PNEUMOCYTE PROTEIN PHOSPHORYLATION
    David Warburton; Fiscal Year: 2010
  7. GLUCOKINASE GENE EXPRESSION IN PANCREATIC BETA CELL
    Mark Magnuson; Fiscal Year: 2005
  8. The Role of Cartilage Link Protein 1 (Crtl1) in Heart Development
    ARNO WESSELS; Fiscal Year: 2010
  9. SONIC HEDGEHOG SIGNALING IN ODONTOGENESIS
    Eiki Koyama; Fiscal Year: 2003
  10. Somatic support cell function in gonad development
    GERRIT BOUMA; Fiscal Year: 2006

Detail Information

Publications197 found, 100 shown here

  1. pmc Inactivation of Dicer1 in Steroidogenic factor 1-positive cells reveals tissue-specific requirement for Dicer1 in adrenal, testis, and ovary
    Chen Che J Huang
    Department of Veterinary Biosciences, University of Illinois, Urbana, IL, USA
    BMC Dev Biol 10:66. 2010
    ..Mouse embryos lacking Dicer1 die in early embryogenesis. In this study, we investigated whether Dicer1 is required for development of adrenal, testis, and ovary in mouse embryos...
  2. ncbi Sox9 is required for cartilage formation
    W Bi
    Department of Molecular Genetics, The University of Texas, M D Anderson Cancer Center, Houston 77030, USA
    Nat Genet 22:85-9. 1999
    ..b>SOX9 is a high-mobility-group (HMG) domain transcription factor that is expressed in chondrocytes and other tissues...
  3. doi Sex determination involves synergistic action of SRY and SF1 on a specific Sox9 enhancer
    Ryohei Sekido
    Division of Developmental Genetics, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Nature 453:930-4. 2008
    ..The related autosomal gene Sox9 is also known from loss-of-function mutations in mice and humans to be essential for Sertoli cell differentiation; ..
  4. ncbi Autosomal sex reversal and campomelic dysplasia are caused by mutations in and around the SRY-related gene SOX9
    T Wagner
    Institute of Human Genetics, University of Freiburg, Federal Republic of Germany
    Cell 79:1111-20. 1994
    ..The SOX9 gene, a positional candidate from the chromosomal location and expression pattern reported for mouse Sox9, was ..
  5. ncbi The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation
    Kazuhisa Nakashima
    Department of Molecular Genetics and Program in Genes and Development, M D Anderson Cancer Center, University of Texas, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Cell 108:17-29. 2002
    ..Thus, Osx acts downstream of Runx2/Cbfa1. Because Osx null preosteoblasts express typical chondrocyte marker genes, we propose that Runx2/Cbfa1-expressing preosteoblasts are still bipotential cells...
  6. pmc Fgf9 and Wnt4 act as antagonistic signals to regulate mammalian sex determination
    Yuna Kim
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina, USA
    PLoS Biol 4:e187. 2006
    ..In the mouse XY gonad, Sry normally initiates a feed-forward loop between Sox9 and Fgf9, which up-regulates Fgf9 and represses Wnt4 to establish the testis pathway...
  7. pmc Stabilization of beta-catenin in XY gonads causes male-to-female sex-reversal
    Danielle M Maatouk
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Hum Mol Genet 17:2949-55. 2008
    ..gene Sry shifts the bipotential gonad toward a testicular fate by upregulating a feed-forward loop between FGF9 and SOX9 to establish SOX9 expression in somatic cells...
  8. pmc SOX9 is an intestine crypt transcription factor, is regulated by the Wnt pathway, and represses the CDX2 and MUC2 genes
    Philippe Blache
    Institut de Genetique Humaine, CNRS UPR1142, 141 rue de la Cardonille, 34396 Montpellier, Cedex 5, France
    J Cell Biol 166:37-47. 2004
    ..Here, we identified SOX9 in a SOX expression screening in the mouse fetal intestine...
  9. ncbi SOX9 is up-regulated by the transient expression of SRY specifically in Sertoli cell precursors
    Ryohei Sekido
    Division of Developmental Genetics, MRC National Institute for Medical Research, London NW7 1AA, UK
    Dev Biol 274:271-9. 2004
    ..The related autosomal gene Sox9 is up-regulated shortly after the onset of Sry transcription and is thought essential for the differentiation of ..
  10. doi R-spondin1 plays an essential role in ovarian development through positively regulating Wnt-4 signaling
    Kazuma Tomizuka
    Discovery Research Laboratories, Research Division, Kirin Pharma Co, Ltd, Takasaki shi, Gunma, 370 1295, Japan
    Hum Mol Genet 17:1278-91. 2008
    ....
  11. doi SOX9 is a major negative regulator of cartilage vascularization, bone marrow formation and endochondral ossification
    Takako Hattori
    Department of Biochemistry and Molecular Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama City 700 8525, Japan
    Development 137:901-11. 2010
    b>SOX9 is a transcription factor of the SRY family that regulates sex determination, cartilage development and numerous other developmental events...
  12. ncbi Sertoli cell differentiation is induced both cell-autonomously and through prostaglandin signaling during mammalian sex determination
    Dagmar Wilhelm
    Division of Molecular Genetics and Development, Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia
    Dev Biol 287:111-24. 2005
    ..The subset of somatic cells that expresses SRY begins to express SOX9 almost immediately...
  13. ncbi A male-specific role for SOX9 in vertebrate sex determination
    J Kent
    Centre for Molecular and Cellular Biology, The University of Queensland, Brisbane, Australia
    Development 122:2813-22. 1996
    ..with campomelic dysplasia, a bone dysmorphology and XY sex reversal syndrome, indicate that the SRY-related gene SOX9 is involved in both skeletal development and sex determination...
  14. ncbi Testis determination requires insulin receptor family function in mice
    Serge Nef
    Center for Developmental Biology, University of Texas, Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, Texas 75390 9133, USA
    Nature 426:291-5. 2003
    ..Reduced expression of both Sry and the early testis-specific marker Sox9 indicates that the insulin signalling pathway is required for male sex determination.
  15. pmc Fibroblast growth factor receptor 2 regulates proliferation and Sertoli differentiation during male sex determination
    Yuna Kim
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 104:16558-63. 2007
    ..Using these two Cre lines, we provide the first genetic evidence that Fgfr2 plays distinct roles in proliferation and Sertoli cell differentiation during testis development...
  16. ncbi Homozygous inactivation of Sox9 causes complete XY sex reversal in mice
    Francisco Barrionuevo
    Institute of Human Genetics and Anthropology, University of Freiburg, D 79106 Freiburg, Germany
    Biol Reprod 74:195-201. 2006
    ..The autosomal gene Sox9, a likely and possibly direct Sry target, can induce testis development in the absence of Sry...
  17. pmc SOX9 is required for maintenance of the pancreatic progenitor cell pool
    Philip A Seymour
    Department of Developmental and Cell Biology, University of California, Irvine, CA 92697 2300, USA
    Proc Natl Acad Sci U S A 104:1865-70. 2007
    ..Here, we identify the transcription factor SOX9 as the first specific marker and maintenance factor of multipotential progenitors during pancreas organogenesis...
  18. pmc Nkx6 transcription factors and Ptf1a function as antagonistic lineage determinants in multipotent pancreatic progenitors
    Ashleigh E Schaffer
    Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, USA
    Dev Cell 18:1022-9. 2010
    ..Thus, cross-antagonism between Nkx6 and Ptf1a in multipotent progenitors governs the equilibrium between endocrine and acinar cell neogenesis required for normal pancreas development...
  19. doi Regulation of Sox9 by Sonic Hedgehog (Shh) is essential for patterning and formation of tracheal cartilage
    Jinhyung Park
    Department of Surgery, Hospital for Sick Children, Toronto, Canada
    Dev Dyn 239:514-26. 2010
    ..and patterning of tracheal cartilage by controlling the expression pattern and level of the chondrogenic gene, Sox9. In Shh(-/-) tracheo-esophageal tubes, Sox9 expression is transient and not restricted ventrally to the site of ..
  20. pmc Nkx2.2 and Arx genetically interact to regulate pancreatic endocrine cell development and endocrine hormone expression
    Teresa L Mastracci
    Department of Genetics and Development, Russ Berrie Medical Pavilion, Columbia University, 1150 St Nicholas Ave, New York, NY 10032, USA
    Dev Biol 359:1-11. 2011
    ..Together, these experiments identify novel genetic interactions between Nkx2.2 and Arx within the endocrine progenitor cells that ensure the correct specification and regulation of endocrine hormone-producing cells...
  21. pmc Sox9 transcriptionally represses Spp1 to prevent matrix mineralization in maturing heart valves and chondrocytes
    Jacqueline D Peacock
    Molecular and Cellular Pharmacology Graduate Program, Leonard M Miller School of Medicine, University of Miami, Miami, Florida, United States of America
    PLoS ONE 6:e26769. 2011
    b>Sox9 is an SRY-related transcription factor required for expression of cartilaginous genes in the developing skeletal system and heart valve structures...
  22. ncbi Differential gene expression in the distal tip endoderm of the embryonic mouse lung
    Yuru Liu
    Department of Cell and Developmental Biology, Howard Hughes Medical Institute, Vanderbilt University Medical Center, Nashville, TN 37232 2175, USA
    Gene Expr Patterns 2:229-33. 2002
    ..5 lung buds, versus more proximal regions. Twenty genes were identified, assigned to different categories based on sequence analysis, and their distal expression confirmed by whole-mount in situ hybridization...
  23. ncbi SOX9 binds DNA, activates transcription, and coexpresses with type II collagen during chondrogenesis in the mouse
    L J Ng
    Department of Biochemistry, Hong Kong University
    Dev Biol 183:108-21. 1997
    Two lines of evidence suggest that the Sry-related gene Sox9 is important for chondrogenesis in mammalian embryos...
  24. ncbi Abnormalities in cartilage and bone development in the Apert syndrome FGFR2(+/S252W) mouse
    Yingli Wang
    Institute of Genetic Medicine, Department of Pediatrics, The Johns Hopkins University School of Medicine, 733 North Broadway, Baltimore, MD 21205, USA
    Development 132:3537-48. 2005
    ..Our results suggest that altered cartilage and bone development play a significant role in the pathogenesis of the Apert syndrome phenotype...
  25. ncbi Sox9 is essential for outer root sheath differentiation and the formation of the hair stem cell compartment
    Valerie P I Vidal
    Inserm U636, Centre de Biochimie, Faculte des Sciences, Parc Valrose, 06108 Nice, France
    Curr Biol 15:1340-51. 2005
    ..However, factors required for the differentiation of this critical cell lineage remain to be identified. Here, we describe an unexpected role of the HMG-box-containing gene Sox9 in hair development.
  26. pmc A dosage-dependent requirement for Sox9 in pancreatic endocrine cell formation
    Philip A Seymour
    Department of Developmental and Cell Biology, University of California, Irvine, Irvine, CA 92697 2300, USA
    Dev Biol 323:19-30. 2008
    We have previously shown the transcription factor SOX9 to be required for the maintenance of multipotential pancreatic progenitor cells in the early embryonic pancreas...
  27. pmc The cerebellin 4 precursor gene is a direct target of SRY and SOX9 in mice
    Stephen T Bradford
    Institute for Molecular Bioscience, The University of Queensland, Queensland, Australia
    Biol Reprod 80:1178-88. 2009
    ..in the developing gonad, with a profile mimicking that of the testis-determining gene SRY-box containing gene 9 (Sox9)...
  28. pmc Distinct SOX9 levels differentially mark stem/progenitor populations and enteroendocrine cells of the small intestine epithelium
    Eric J Formeister
    Department of Medicine, Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill, NC 27599, USA
    Am J Physiol Gastrointest Liver Physiol 296:G1108-18. 2009
    ..b>SOX9 is expressed in the small intestine epithelial stem cell zone...
  29. pmc Loss of mitogen-activated protein kinase kinase kinase 4 (MAP3K4) reveals a requirement for MAPK signalling in mouse sex determination
    Debora Bogani
    Mammalian Genetics Unit, Medical Research Council MRC Harwell, Oxfordshire, United Kingdom
    PLoS Biol 7:e1000196. 2009
    ..male (XY) gonad, sex-determining region of the Y (SRY) protein acts to up-regulate expression of the related gene, SOX9, a transcriptional regulator that in turn initiates a downstream pathway of testis development, whilst also ..
  30. ncbi The battle of the sexes
    B Capel
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Mech Dev 92:89-103. 2000
    ....
  31. ncbi Fgf9 induces proliferation and nuclear localization of FGFR2 in Sertoli precursors during male sex determination
    Jennifer Schmahl
    Department of Cell Biology, Duke University, Durham, NC 27710, USA
    Development 131:3627-36. 2004
    ..The nuclear localization of FGFR2 coincides with the initiation of Sry expression and the nuclear localization of SOX9 during the early differentiation of Sertoli cells and the determination of male fate.
  32. pmc Pdgfr-alpha mediates testis cord organization and fetal Leydig cell development in the XY gonad
    Jennifer Brennan
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Genes Dev 17:800-10. 2003
    ..This work identifies PDGF signaling through the alpha receptor as an important event downstream of Sry in testis organogenesis and Leydig cell differentiation...
  33. pmc Sox9-haploinsufficiency causes glucose intolerance in mice
    Claire L Dubois
    Department of Pediatrics and Cellular and Molecular Medicine, University of California San Diego, La Jolla, California, United States of America
    PLoS ONE 6:e23131. 2011
    The HMG box transcription factor Sox9 plays a critical role in progenitor cell expansion during pancreas organogenesis and is required for proper endocrine cell development in the embryo...
  34. pmc Arx and Nkx2.2 compound deficiency redirects pancreatic alpha- and beta-cell differentiation to a somatostatin/ghrelin co-expressing cell lineage
    Simon Kordowich
    Department of Molecular Cell Biology, Max Planck Institute for Biophysical Chemistry, Am Fassberg, Gottingen, Germany
    BMC Dev Biol 11:52. 2011
    ..2-deficient pancreata. Hence in order to precise the functional link between both factors we performed a comparative analysis of Nkx2.2/Arx single- and double-mutants but also of Pax6-deficient animals...
  35. pmc Sox9 and NFIA coordinate a transcriptional regulatory cascade during the initiation of gliogenesis
    Peng Kang
    Center for Cell and Gene Therapy, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Neuron 74:79-94. 2012
    ..a crucial role in the onset of gliogenesis; we found that its induction is regulated by the transcription factor Sox9 and that this relationship mediates the initiation of gliogenesis...
  36. pmc Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3-independent beta-catenin degradation
    Lilia Topol
    Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Cell Biol 162:899-908. 2003
    ..Furthermore, we provide evidence that Wnt-5a also acts in vivo to promote beta-catenin degradation in regulating mammalian limb development and possibly in suppressing tumor formation...
  37. ncbi Small ubiquitin-like modifier 1 (SUMO-1) modification of the synergy control motif of Ad4 binding protein/steroidogenic factor 1 (Ad4BP/SF-1) regulates synergistic transcription between Ad4BP/SF-1 and Sox9
    Tomoko Komatsu
    Department of Developmental Biology, National Institute for Basic Biology, Okazaki 444 8787, Japan
    Mol Endocrinol 18:2451-62. 2004
    ..predominantly under the control of Ad4BP/SF-1 and, moreover, its transcription is regulated synergistically with Sox9, Gata4, and Wt1...
  38. pmc The transcription factor Sox5 modulates Sox10 function during melanocyte development
    C Claus Stolt
    Institut fur Biochemie, Emil Fischer Zentrum, Universitat Erlangen, Fahrstrasse 17, D 91054 Erlangen, Germany
    Nucleic Acids Res 36:5427-40. 2008
    ..Both binding site competition and recruitment of corepressors thus help Sox5 to modulate the activity of Sox10 in the melanocyte lineage...
  39. doi Sox9 sustains chondrocyte survival and hypertrophy in part through Pik3ca-Akt pathways
    Daisuke Ikegami
    Departments of Bone and Cartilage Biology, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka, Japan
    Development 138:1507-19. 2011
    During endochondral bone formation, Sox9 expression starts in mesenchymal progenitors, continues in the round and flat chondrocyte stages at high levels, and ceases just prior to the hypertrophic chondrocyte stage...
  40. doi XY Sox9 embryonic loss-of-function mouse mutants show complete sex reversal and produce partially fertile XY oocytes
    Rowena Lavery
    Inserm U636, Nice, France
    Dev Biol 354:111-22. 2011
    ..expression of the Y chromosomal testis determining factor Sry leads to up-regulation of the transcription factor Sox9 which promotes testis differentiation...
  41. pmc A nuclear export signal within the high mobility group domain regulates the nucleocytoplasmic translocation of SOX9 during sexual determination
    Stephan Gasca
    Human Molecular Genetics Group, Institut de Genetique Humaine, Centre National de la Recherche Scientifique Unité Propre de Recherche 1142, 34396 Montpellier Cedex 5, France
    Proc Natl Acad Sci U S A 99:11199-204. 2002
    ..One of the earliest effect of Sry expression is to induce up-regulation of Sox9 gene expression in the developing gonad...
  42. pmc Transcriptional coactivator PGC-1alpha regulates chondrogenesis via association with Sox9
    Yasuhiko Kawakami
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 102:2414-9. 2005
    ..The transcription factor Sox9 (SRY-related high mobility group-Box gene 9) regulates chondrocyte differentiation and cartilage-specific ..
  43. pmc Wnt and FGF signals interact to coordinate growth with cell fate specification during limb development
    Derk ten Berge
    Howard Hughes Medical Institute, Department of Developmental Biology, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA
    Development 135:3247-57. 2008
    ....
  44. doi Differential expression of sphingosine-1-phosphate receptors 1-5 in the developing nervous system
    H Meng
    Division of Developmental Biology, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Dev Dyn 238:487-500. 2009
    ..On the contrary, S1pr3 was predominantly detected in non-neuronal cells within and surrounding neural structures. We also described novel expression sites for S1P receptors in the developing nervous system...
  45. pmc Reduced sox9 function promotes heart valve calcification phenotypes in vivo
    Jacqueline D Peacock
    Department of Molecular and Cellular Pharmacology, Leonard M Miller School of Medicine, University of Miami, 1600 NW 10th Ave, Miami, FL 33136, USA
    Circ Res 106:712-9. 2010
    ..The SRY-related transcription factor Sox9 is expressed in developing and mature heart valves, and its function is required for expression of cartilage-..
  46. ncbi Sox9 expression during gonadal development implies a conserved role for the gene in testis differentiation in mammals and birds
    S Morais da Silva
    Division of Developmental Genetics, MRC National Institute for Medical Research, Mill Hill, London, UK
    Nat Genet 14:62-8. 1996
    Heterozygous mutations in SOX9 lead to a human dwarfism syndrome, Campomelic dysplasia...
  47. ncbi Parallel expression of Sox9 and Col2a1 in cells undergoing chondrogenesis
    Q Zhao
    Department of Molecular Genetics, The University of Texas, M D Anderson Cancer Center, Houston 77030, USA
    Dev Dyn 209:377-86. 1997
    To assess the role of the transcription factor Sox9 in cartilage formation we have compared the expression pattern of Sox9 and Col2a1 at various stages of mouse embryonic development...
  48. pmc Deletion of long-range regulatory elements upstream of SOX9 causes campomelic dysplasia
    V M Wunderle
    Department of Genetics, University of Cambridge, Downing Street, CB2 3EH Cambridge, United Kingdom
    Proc Natl Acad Sci U S A 95:10649-54. 1998
    ..Patients present with either heterozygous mutations in the SOX9 gene or chromosome rearrangements mapping at least 50 kb upstream of SOX9...
  49. pmc Essential role of Sox9 in the pathway that controls formation of cardiac valves and septa
    Haruhiko Akiyama
    Department of Molecular Genetics, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 101:6502-7. 2004
    ..Several gene mutations are known to affect cardiac valve formation. Sox9 is activated when endocardial endothelial cells undergo mesenchymal transformation and migrate into an ..
  50. ncbi Canonical Wnt/beta-catenin signaling prevents osteoblasts from differentiating into chondrocytes
    Theo P Hill
    Research Institute for Molecular Pathology, Vienna, Austria
    Dev Cell 8:727-38. 2005
    ..activity is necessary and sufficient to repress the differentiation of mesenchymal cells into Runx2- and Sox9-positive skeletal precursors...
  51. ncbi Expression profile of Papss2 (3'-phosphoadenosine 5'-phosphosulfate synthase 2) during cartilage formation and skeletal development in the mouse embryo
    Christiane Stelzer
    Children s Hospital, University of Mainz, Mainz, Germany
    Dev Dyn 236:1313-8. 2007
    ....
  52. doi Activation of beta-catenin signaling by Rspo1 controls differentiation of the mammalian ovary
    Anne Amandine Chassot
    INSERM, U636, F 06108 Nice, France
    Hum Mol Genet 17:1264-77. 2008
    The sex of an individual is determined by the fate of the gonad. While the expression of Sry and Sox9 is sufficient to induce male development, we here show that female differentiation requires activation of the canonical beta-catenin ..
  53. pmc The diabetes gene Pdx1 regulates the transcriptional network of pancreatic endocrine progenitor cells in mice
    Jennifer M Oliver-Krasinski
    Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    J Clin Invest 119:1888-98. 2009
    ..of all 4 members of the transcription factor network that regulates Ngn3 expression, SRY-box containing gene 9 (Sox9), Hnf6, Hnf1b, and forkhead box A2 (Foxa2), were decreased in homozygous mice...
  54. pmc Sox9 is required for determination of the chondrogenic cell lineage in the cranial neural crest
    Yuko Mori-Akiyama
    Department of Molecular Genetics, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 100:9360-5. 2003
    b>Sox9 has essential roles in endochondral bone formation during axial and appendicular skeletogenesis. Sox9 is also expressed in neural crest cells, but its function in neural crest remains largely unknown...
  55. pmc Bmpr1a and Bmpr1b have overlapping functions and are essential for chondrogenesis in vivo
    Byeong S Yoon
    Department of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 102:5062-7. 2005
    ..We demonstrate that this defect in chondrocytic differentiation can be attributed to lack of Sox9, L-Sox5, and Sox6 expression in precartilaginous condensations in double mutants...
  56. ncbi SOX8 is expressed during testis differentiation in mice and synergizes with SF1 to activate the Amh promoter in vitro
    Goslik Schepers
    Institute for Molecular Bioscience, The University of Queensland, Brisbane 4072, Australia
    J Biol Chem 278:28101-8. 2003
    Sox8 is a member of the Sox family of developmental transcription factor genes and is closely related to Sox9, a key gene in the testis determination pathway in mammals...
  57. doi Bone morphogenetic protein-2 induces chromatin remodeling and modification at the proximal promoter of Sox9 gene
    Qiuhui Pan
    Medical Research Center, No 2 Affiliated Hospital, Sun Yat Sen University, Guangzhou 510120, PR China
    Biochem Biophys Res Commun 379:356-61. 2009
    b>Sox9 is a key transcription factor which plays an important role in chondrogenesis. Although Bone Morphogenetic Protein-2 (BMP-2) has been reported to induce Sox9 expression, the underlying molecular mechanism remains elusive...
  58. pmc The Maestro (Mro) gene is dispensable for normal sexual development and fertility in mice
    Lee Smith
    Mammalian Genetics Unit, MRC Harwell, Oxfordshire, UK
    PLoS ONE 3:e4091. 2008
    ....
  59. pmc Antagonism of the testis- and ovary-determining pathways during ovotestis development in mice
    Dagmar Wilhelm
    Division of Molecular Genetics and Development, Institute for Molecular Biosciences, The University of Queensland, QLD, Australia
    Mech Dev 126:324-36. 2009
    ..We studied expression of several markers of mouse fetal testis (SRY, SOX9) or ovary (FOXL2, Rspo1) development in B6-XY(POS) ovotestes by immunofluorescence, using normal testes and ovaries ..
  60. ncbi SOX9 directly regulates the type-II collagen gene
    D M Bell
    Department of Biochemistry, University of Hong Kong, Hong Kong
    Nat Genet 16:174-8. 1997
    Mutations in human SOX9 are associated with campomelic dysplasia (CD), characterised by skeletal malformation and XY sex reversal...
  61. ncbi Mint represses transactivation of the type II collagen gene enhancer through interaction with alpha A-crystallin-binding protein 1
    Xi Yang
    Department of Medical Genetics and Developmental Biology, State Key Laboratory of Cancer Biology, Fourth Military Medical University, Xian 710032, China
    J Biol Chem 280:18710-6. 2005
    ..The present study shows that MINT is involved in CRYBP1-mediated Col2a1 gene repression and may play a role in regulation of cartilage development...
  62. ncbi Misexpression of Sox9 in mouse limb bud mesenchyme induces polydactyly and rescues hypodactyly mice
    Haruhiko Akiyama
    Department of Orthopaedics, Kyoto University, Kyoto 606 8507, Japan
    Matrix Biol 26:224-33. 2007
    Our previous studies have demonstrated the essential roles of the transcription factor Sox9 in the commitment of mesenchymal cells to a chondrogenic cell lineage and in overt chondrogenesis during limb bud development...
  63. pmc Acheate-scute like 1 (Ascl1) is required for normal delta-like (Dll) gene expression and notch signaling during retinal development
    Branden R Nelson
    Department of Biological Structure, School of Medicine, University of Washington, Seattle, Washington 98195, USA
    Dev Dyn 238:2163-78. 2009
    ..Thus, these results suggest a molecular mechanism whereby attenuated Notch levels coupled with reduced proneurogenic activity in progenitors leads to increased gliogenesis and decreased neurogenesis in the Ascl1-deficient retina...
  64. doi A self-regulatory system of interlinked signaling feedback loops controls mouse limb patterning
    Jean Denis Bénazet
    Developmental Genetics, Department of Biomedicine, University of Basel, Mattenstrasse 28, CH 4058 Basel, Switzerland
    Science 323:1050-3. 2009
    ..This self-regulatory signaling network results in robust regulation of distal limb development that is able to compensate for variations by interconnectivity among the three signaling pathways...
  65. pmc Extracellular signal-regulated kinase 1 (ERK1) and ERK2 play essential roles in osteoblast differentiation and in supporting osteoclastogenesis
    Takehiko Matsushita
    Department of Orthopaedics, Case Western Reserve University, 2109 Adelbert Road, BRB 329, Cleveland, OH 44106, USA
    Mol Cell Biol 29:5843-57. 2009
    ..Thus, our results indicate that ERK1 and ERK2 not only play essential roles in the lineage specification of osteo-chondroprogenitor cells but also support osteoclast formation in vivo...
  66. pmc A mouse model for Meckel syndrome reveals Mks1 is required for ciliogenesis and Hedgehog signaling
    Scott D Weatherbee
    Developmental Biology Program, Sloan Kettering Institute, New York, NY 10065, USA
    Hum Mol Genet 18:4565-75. 2009
    ..Thus the disruption of Hh signaling can explain many, but not all, of the defects caused by loss of Mks1...
  67. pmc E-selectin ligand-1 regulates growth plate homeostasis in mice by inhibiting the intracellular processing and secretion of mature TGF-beta
    Tao Yang
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    J Clin Invest 120:2474-85. 2010
    ..This study identifies what we believe to be a novel intracellular mechanism for regulating TGF-beta during skeletal development and homeostasis...
  68. pmc Dominance of SOX9 function over RUNX2 during skeletogenesis
    Guang Zhou
    Howard Hughes Medical Institute and Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 103:19004-9. 2006
    Mesenchymal stem cell-derived osteochondroprogenitors express two master transcription factors, SOX9 and RUNX2, during condensation of the skeletal anlagen...
  69. pmc Sox9 coordinates a transcriptional network in pancreatic progenitor cells
    F C Lynn
    Diabetes Center, Hormone Research Institute, and Department of Medicine, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 104:10500-5. 2007
    ..The Sry/HMG box transcription factor Sox9 is also expressed in the early pancreatic epithelium and is required for normal pancreatic exocrine and endocrine ..
  70. pmc Activation of the Hedgehog pathway in the mouse fetal ovary leads to ectopic appearance of fetal Leydig cells and female pseudohermaphroditism
    Ivraym B Barsoum
    Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, IL 61820, USA
    Dev Biol 329:96-103. 2009
    ..This study provides not only insights into mechanisms of cell lineage specification in gonads, but also a model to understand defects in sexual differentiation...
  71. pmc Phosphorylation of SOX9 by cyclic AMP-dependent protein kinase A enhances SOX9's ability to transactivate a Col2a1 chondrocyte-specific enhancer
    W Huang
    Department of Molecular Genetics, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Mol Cell Biol 20:4149-58. 2000
    b>Sox9 is a high-mobility-group domain-containing transcription factor required for chondrocyte differentiation and cartilage formation...
  72. ncbi Bone morphogenetic protein signals are required for cartilage formation and differently regulate joint development during skeletogenesis
    Noriyuki Tsumaki
    Department of Orthopaedic Surgery, Osaka Police Hospital, Japan
    J Bone Miner Res 17:898-906. 2002
    ..These effects seem to be mediated through down-regulation of Sox9 expression...
  73. ncbi p107 and p130 Coordinately regulate proliferation, Cbfa1 expression, and hypertrophic differentiation during endochondral bone development
    Ferdinand Rossi
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York, 10032, USA
    Dev Biol 247:271-85. 2002
    ..The results suggest that Cbfa1 links a p107- and p130-mediated cell cycle arrest to chondrocyte terminal differentiation...
  74. pmc TGF beta 1 inhibits Ca2+-calcineurin-mediated activation in thymocytes
    Ramireddy Bommireddy
    Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0524, USA
    J Immunol 170:3645-52. 2003
    ..Consequently, TGFbeta1 prevents autoimmune disease through a Ca(2+) regulatory pathway that maintains the activation threshold above that inducible by self-MHC-TCR interactions...
  75. ncbi Cell proliferation is necessary for the determination of male fate in the gonad
    Jennifer Schmahl
    Department of Cell Biology, Duke University, Durham, NC 27710, USA
    Dev Biol 258:264-76. 2003
    ..We believe these studies suggest that proliferation is involved not only in the elaboration of organ pattern, but also in the choice between patterns (male and female) in the bipotential gonad...
  76. ncbi Overlapping expression of Runx1(Cbfa2) and Runx2(Cbfa1) transcription factors supports cooperative induction of skeletal development
    Nathan Smith
    The Center for Musculoskeletal Research, University of Rochester, Rochester, New York, USA
    J Cell Physiol 203:133-43. 2005
    ....
  77. ncbi The transcription factors steroidogenic factor-1 and SOX9 regulate expression of Vanin-1 during mouse testis development
    Megan J Wilson
    Institute for Molecular Bioscience, The University of Queensland, Brisbane 4072, Queensland, Australia
    J Biol Chem 280:5917-23. 2005
    ..Vanin-1 is co-expressed with the transcription factors steroidogenic factor-1 (SF-1) and SOX9 in Sertoli cells and, at a lower level, with SF-1 in Leydig cells in developing testes...
  78. ncbi Gli3 and Plzf cooperate in proximal limb patterning at early stages of limb development
    Maria Barna
    Weill Graduate School of Medical Sciences, Cornell University, New York, New York 10021, USA
    Nature 436:277-81. 2005
    ..The initial division of the vertebrate limb into two distinct molecular domains is consistent with fossil evidence indicating that the upper and lower extremities of the limb have different evolutionary origins...
  79. ncbi Cytokine-like 1 (Cytl1) regulates the chondrogenesis of mesenchymal cells
    Jae Sung Kim
    Department of Life Sciences, Research Center for Biomolecular Nanotechnology, Gwangju Institute of Science and Technology, Gwangju 500 712, Korea
    J Biol Chem 282:29359-67. 2007
    ..Cytl1 exerted its chondrogenic effect via stimulation of Sox9 transcriptional activity...
  80. pmc Insulin receptor substrate-1 deficiency promotes apoptosis in the putative intestinal crypt stem cell region, limits Apcmin/+ tumors, and regulates Sox9
    Nicole M Ramocki
    Department of Cell and Molecular Physiology, University of North Carolina at Chapel Hill, North Carolina 27599 7545, USA or
    Endocrinology 149:261-7. 2008
    ..Expression of Sox9, a transcriptional target of Tcf/beta-catenin and putative biomarker of crypt stem cells, was assessed in intestine ..
  81. pmc Pref-1 regulates mesenchymal cell commitment and differentiation through Sox9
    Yuhui Wang
    Department of Nutritional Science and Toxicology, University of California, Berkeley, Berkeley, CA 94720, USA
    Cell Metab 9:287-302. 2009
    ..Here, we show that Sox9 downregulation is required for adipocyte differentiation and that Pref-1 inhibits adipocyte differentiation through ..
  82. doi The group E Sox genes Sox8 and Sox9 are regulated by Notch signaling and are required for Müller glial cell development in mouse retina
    Akihiko Muto
    Department of Molecular and Developmental Biology, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokane dai, Minato ku, Tokyo 108 8639, Japan
    Exp Eye Res 89:549-58. 2009
    ..We found that two group E Sox genes, Sox8 and Sox9, are expressed in proliferating progenitors and then exclusively in Müller glial cells in mouse retina...
  83. ncbi Developmental-specific activity of the FGF-4 enhancer requires the synergistic action of Sox2 and Oct-3
    H Yuan
    Department of Microbiology, New York University School of Medicine, New York 10016, USA
    Genes Dev 9:2635-45. 1995
    ....
  84. ncbi The Sry-related gene Sox9 is expressed during chondrogenesis in mouse embryos
    E Wright
    Centre for Molecular and Cellular Biology, University of Queensland, Brisbane, Australia
    Nat Genet 9:15-20. 1995
    Mutations in the human SRY-related gene, SOX9, located on chromosome 17, have recently been associated with the sex reversal and skeletal dysmorphology syndrome, campomelic dysplasia...
  85. ncbi Regulation and role of Sox9 in cartilage formation
    C Healy
    Department of Craniofacial Development, GKT Dental Institute, Kings College London, Guy s Hospital
    Dev Dyn 215:69-78. 1999
    The HMG-domain transcription factor Sox9 is a known regulator of the type II collagen gene, a major developmentally regulated protein of cartilage...
  86. pmc Haploinsufficiency of Sox9 results in defective cartilage primordia and premature skeletal mineralization
    W Bi
    Department of Molecular Genetics and Graduate Program in Genes and Development, M D Anderson Cancer Center, University of Texas, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 98:6698-703. 2001
    In humans, SOX9 heterozygous mutations cause the severe skeletal dysmorphology syndrome campomelic dysplasia. Except for clinical descriptions, little is known about the pathogenesis of this disease...
  87. ncbi Sox9 induces testis development in XX transgenic mice
    V P Vidal
    MDC for Molecular Medicine, Robert Rossle Strasse 10, 13092 Berlin, Germany
    Nat Genet 28:216-7. 2001
    Mutations in SOX9 are associated with male-to-female sex reversal in humans. To analyze Sox9 function during sex determination, we ectopically expressed this gene in XX gonads...
  88. ncbi Functions of FGF signalling from the apical ectodermal ridge in limb development
    Xin Sun
    Department of Anatomy and Program in Developmental Biology, School of Medicine, University of California at San Francisco, 94143 0452, USA
    Nature 418:501-8. 2002
    ..In the complete absence of both FGF4 and FGF8 activities, limb development fails. We present a model to explain how the mutant phenotypes arise from FGF-mediated effects on limb bud size and cell survival...
  89. ncbi Gonadal differentiation, sex determination and normal Sry expression in mice require direct interaction between transcription partners GATA4 and FOG2
    Sergei G Tevosian
    Division of Hematology and Oncology, Children s Hospital, Harvard Medical School, Boston, MA, USA
    Development 129:4627-34. 2002
    ..In addition, three genes crucial for normal Sertoli cell function (Sox9, Mis and Dhh) and three Leydig cell steroid biosynthetic enzymes (p450scc, 3betaHSD and p450c17) were not expressed ..
  90. ncbi Mouse Wnt9b transforming activity, tissue-specific expression, and evolution
    JunQing Qian
    Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Genomics 81:34-46. 2003
    ..Overexpression of Wnt9b in C57MG mammary epithelial cells caused small transformed foci in cell monolayers and a moderate morphological transformation in pooled colonies compared with Wnt1...
  91. ncbi Sox8 is a specific marker for muscle satellite cells and inhibits myogenesis
    Katy Schmidt
    Institut für Biochemie der Universität Erlangen Nürnberg, D 91054 Erlangen, Germany
    J Biol Chem 278:29769-75. 2003
    ..was also detected in cell culture systems and occurred in parallel with down-regulation of the related Sox9. Overexpression of Sox8 or Sox9 on the other hand disrupted myoblasts in their ability to form myotubes...
  92. ncbi Control of skeletal patterning by ephrinB1-EphB interactions
    Amelia Compagni
    Cancer Research UK London Research Institute, Vascular Development Laboratory, WC2A 3PX, London, United Kingdom
    Dev Cell 5:217-30. 2003
    ..Our findings suggest that differential cell adhesion and sorting might be relevant for an unusual class of X-linked human genetic disorders, in which heterozygous females show more severe phenotypes than hemizygous males...
  93. ncbi Multiple roles of Hoxa11 and Hoxd11 in the formation of the mammalian forelimb zeugopod
    Anne M Boulet
    Howard Hughes Medical Institute, Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, UT 84112, USA
    Development 131:299-309. 2004
    ..As a consequence, growth and maturation of these bones is highly disorganized, resulting in the creation of amorphous bony elements, rather than a normal radius and ulna...
  94. ncbi Functional analysis of Sox8 and Sox9 during sex determination in the mouse
    Marie Christine Chaboissier
    INSERM U470, Centre de Biochimie, Parc Valrose, 06108 Nice Cedex 2, France
    Development 131:1891-901. 2004
    ..gene Sry, which leads to the activation of male-specific genes including the HMG-box containing gene Sox9. From transgenic studies in mice it is clear that Sox9 is sufficient to induce testis formation...
  95. pmc Interactions between Sox9 and beta-catenin control chondrocyte differentiation
    Haruhiko Akiyama
    Department of Molecular Genetics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Genes Dev 18:1072-87. 2004
    ..Here we show the existence of physical and functional interactions between beta-catenin and Sox9, a transcription factor that is required in successive steps of chondrogenesis...
  96. pmc Follistatin operates downstream of Wnt4 in mammalian ovary organogenesis
    Humphrey H C Yao
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina, USA
    Dev Dyn 230:210-5. 2004
    ..Thus, we propose that WNT4 acts through FST to regulate vascular boundaries and maintain germ cell survival in the ovary...
  97. ncbi Bmp4 in limb bud mesoderm regulates digit pattern by controlling AER development
    Jennifer Selever
    Alkek Institute of Biosciences and Technology, Texas A and M System Health Science Center, Houston, TX 77030, USA
    Dev Biol 276:268-79. 2004
    ..Our data show that Bmp4 in limb mesoderm regulates AER induction and maturation and implicate signaling from the AER in regulation of digit number and identity...
  98. ncbi Wnt4 is required for proper male as well as female sexual development
    Katherine Jeays-Ward
    Section of Gene Function and Regulation, Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK
    Dev Biol 276:431-40. 2004
    ..in Wnt4 mutant testes and that this defect occurs downstream of the testis-determining gene Sry but upstream of Sox9 and Dhh, two early Sertoli cell markers...
  99. ncbi Normal lung development and function after Sox9 inactivation in the respiratory epithelium
    Anne Karina T Perl
    Children s Hospital Medical Center, Division of Pulmonary Biology, Cincinnati, Ohio 45229 3039, USA
    Genesis 41:23-32. 2005
    Heterozygous mutations in the human SOX9 gene cause campomelic dysplasia (CD), a skeletal malformation syndrome with various other organ defects. Severely affected CD patients usually die in the neonatal period due to respiratory distress...
  100. ncbi The transcription factor Sox9 is degraded by the ubiquitin-proteasome system and stabilized by a mutation in a ubiquitin-target site
    Haruhiko Akiyama
    Department of Molecular Genetics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Matrix Biol 23:499-505. 2005
    b>Sox9 is a transcription factor that is critical for chondrogenesis, testis determination, and development of several other organs in vertebrates. Thus the levels of Sox9 protein and its activity may be tightly regulated...
  101. ncbi Nmyc plays an essential role during lung development as a dosage-sensitive regulator of progenitor cell proliferation and differentiation
    Tadashi Okubo
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Development 132:1363-74. 2005
    ..In addition, there is marked inhibition of differentiation, coupled with an expanded domain of expression of Sox9 protein, which is also normally restricted to the distal epithelial compartment...

Research Grants16

  1. Excess TGF beta in neonatal lung injury and repair
    David Warburton; Fiscal Year: 2004
    ..abstract_text> ..
  2. The role of HNF4 in gastrointestinal development
    Michele Battle; Fiscal Year: 2006
    ..By understanding how this transcription factor functions in the gut, greater insight into the fundamental molecular processes underlying gut development wilt be gained. ..
  3. Lung epithelial and vascular morphogenesis
    David Warburton; Fiscal Year: 2006
    ..abstract_text> ..
  4. AUTOCRINE/PARACRINE GROWTH FACTORS & LUNG MORPHOGENESIS
    David Warburton; Fiscal Year: 2009
    ..Aim 4: To determine the role of tyrosine phosphorylation in protein-protein interaction and supra-molecular assembly of mSPRY2 with SHP2 and FRS2. Aim 5: To determine the functional importance of Shp2 in lung morphogenesis in vivo. ..
  5. ROLES OF SOX C GENES IN SKELETOGENESIS
    VERONIQUE M LEFEBVRE; Fiscal Year: 2010
    ....
  6. DEVELOPMENTAL TYPE II PNEUMOCYTE PROTEIN PHOSPHORYLATION
    David Warburton; Fiscal Year: 2010
    ..Inosine may function as a low molecular weight therapeutic to ameliorate lung injury, protect lung progenitor cells and hence to promote recovery of the alveolar epithelium from acute injury in both adult and neonate. ..
  7. GLUCOKINASE GENE EXPRESSION IN PANCREATIC BETA CELL
    Mark Magnuson; Fiscal Year: 2005
    ..In Aim 3 we will determine the role of alternate RNA processing the insulin receptor in modulating both GK gene transcription and subcellular localization in the pancreatic beta cell. ..
  8. The Role of Cartilage Link Protein 1 (Crtl1) in Heart Development
    ARNO WESSELS; Fiscal Year: 2010
    ..Understanding the role of Crtl1, and Crtl1-associated mechanisms, in heart development may further our knowledge of the etiology of a variety of these malformations including the mechanisms that lead to muscular septal defects. ..
  9. SONIC HEDGEHOG SIGNALING IN ODONTOGENESIS
    Eiki Koyama; Fiscal Year: 2003
    ..The results of the project will provide key information on morphogenetic and cellular signals responsible for initiation and progression of odontogenesis. ..
  10. Somatic support cell function in gonad development
    GERRIT BOUMA; Fiscal Year: 2006
    ..The proposed experiments will identify genes expressed in gonadal SSCs that play a role in gonadal XY sex reversal. ..
  11. Fourth Symposium Biology Vertebrate Sex Determination
    Blanche Capel; Fiscal Year: 2006
    ..Understanding how critical genes in sex determining pathways evolved and how they function in lower vertebrates is expected to improve diagnosis and treatment of human disorders. [unreadable] [unreadable] [unreadable]..
  12. Organ-specific Mechanisms of Vascular Development
    Blanche Capel; Fiscal Year: 2007
    ..In addition, the molecular signals that control or repress the growth of vasculature into a tissue are of critical concern for the design of therapies in the fields of wound healing and tumor biology. [unreadable] [unreadable]..
  13. TGF-beta Signaling in Mesenchymal Chondroprogenitors
    Anna Spagnoli; Fiscal Year: 2007
    ..Understanding the role of TGF-beta in MCC biology will provide a framework for therapeutic manipulations to optimize the use of MCC in cartilage diseases. ..
  14. Regulation of parietal bone differentiation
    Venkatesh Govindarajan; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  15. OPPOSING PATHWAYS IN MAMMALIAN SEX DETERMINATION
    Blanche Capel; Fiscal Year: 2010
    ..expression of Sry controls a cell fate decision in Sertoli cell precursors that leads to the stable expression of Sox9 throughout the Sertoli lineage...
  16. Molecular Regulation of Ocular Gland Development
    Venkatesh Govindarajan; Fiscal Year: 2010
    ..In addition, the proposed studies will, in the long-term, allow the development of novel therapeutic approaches for treatment of patients with dry eye syndromes. ..