Sox2

Summary

Gene Symbol: Sox2
Description: SRY (sex determining region Y)-box 2
Alias: Sox-2, lcc, ysb, transcription factor SOX-2, SRY-box containing gene 2
Species: mouse

Top Publications

  1. pmc Multipotent cell lineages in early mouse development depend on SOX2 function
    Ariel A Avilion
    Division of Developmental Genetics, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Genes Dev 17:126-40. 2003
  2. pmc In vivo fate analysis reveals the multipotent and self-renewal capacities of Sox2+ neural stem cells in the adult hippocampus
    Hoonkyo Suh
    Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Cell Stem Cell 1:515-28. 2007
  3. doi Hippocampal development and neural stem cell maintenance require Sox2-dependent regulation of Shh
    Rebecca Favaro
    Department of Biotechnology and Biosciences, University of Milano Bicocca, Milano, Italy
    Nat Neurosci 12:1248-56. 2009
  4. pmc SOX2 is a dose-dependent regulator of retinal neural progenitor competence
    Olena V Taranova
    Department of Genetics, University of North Carolina at Chapel Hill, NC 27599, USA
    Genes Dev 20:1187-202. 2006
  5. ncbi Sox2 is required for sensory organ development in the mammalian inner ear
    Amy E Kiernan
    MRC Institute of Hearing Research, University of Nottingham, Nottingham NG7 2RD, UK
    Nature 434:1031-5. 2005
  6. ncbi Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4
    J Nichols
    Centre for Genome Research, University of Edinburgh, United Kingdom
    Cell 95:379-91. 1998
  7. pmc Sox2(+) adult stem and progenitor cells are important for tissue regeneration and survival of mice
    Katrin Arnold
    Howard Hughes Medical Institute and Department of Stem Cell and Regenerative Biology, Harvard University and Harvard Medical School, Cambridge, MA 02138, USA
    Cell Stem Cell 9:317-29. 2011
  8. pmc Analysis of congenital hypomyelinating Egr2Lo/Lo nerves identifies Sox2 as an inhibitor of Schwann cell differentiation and myelination
    Nam Le
    Department of Pathology and Immunology, Washington University School of Medicine, 660 South Euclid Avenue, Box 8118, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 102:2596-601. 2005
  9. ncbi Role of Sox2 in the development of the mouse neocortex
    Mahmud Bani-Yaghoub
    Neurogenesis and Brain Repair Group, Neurobiology Program, Institute for Biological Sciences, National Research Council of Canada, 1200 Montreal Rd, Bldg M 54, Ottawa, ON, Canada K1A 0R6
    Dev Biol 295:52-66. 2006
  10. doi Consequence of the loss of Sox2 in the developing brain of the mouse
    Satoru Miyagi
    Division of Developmental Biology, Research Center for Genomic Medicine, Saitama Medical University, 1397 1 Yamane, Hidaka, Saitama 350 1241, Japan
    FEBS Lett 582:2811-5. 2008

Research Grants

  1. Excess TGF beta in neonatal lung injury and repair
    David Warburton; Fiscal Year: 2004
  2. Lung epithelial and vascular morphogenesis
    David Warburton; Fiscal Year: 2006
  3. MECHANISMS OF RAAV TRANSDUCTION IN THE AIRWAY
    JOHN ENGELHARDT; Fiscal Year: 2008
  4. Redox-mediated NF-kappaB activation by LPS and IL-1
    JOHN ENGELHARDT; Fiscal Year: 2008
  5. AUTOCRINE/PARACRINE GROWTH FACTORS & LUNG MORPHOGENESIS
    David Warburton; Fiscal Year: 2009
  6. DEVELOPMENTAL TYPE II PNEUMOCYTE PROTEIN PHOSPHORYLATION
    David Warburton; Fiscal Year: 2010
  7. The function of Foxi3 in craniofacial development
    Takahiro Ohyama; Fiscal Year: 2008
  8. Cell survival and cell death in the auditory nerve
    Hainan Lang; Fiscal Year: 2008
  9. Afferent Innervation of the Postnatal Cochlea
    CLIFFORD HUME; Fiscal Year: 2008
  10. DISSECTING THE EAR NEUROSENSORY DEVELOPMENT.
    Bernd Fritzsch; Fiscal Year: 2010

Detail Information

Publications173 found, 100 shown here

  1. pmc Multipotent cell lineages in early mouse development depend on SOX2 function
    Ariel A Avilion
    Division of Developmental Genetics, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Genes Dev 17:126-40. 2003
    ..The transcription factor SOX2 has also been implicated in the regulation of Fgf4 expression...
  2. pmc In vivo fate analysis reveals the multipotent and self-renewal capacities of Sox2+ neural stem cells in the adult hippocampus
    Hoonkyo Suh
    Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Cell Stem Cell 1:515-28. 2007
    To characterize the properties of adult neural stem cells (NSCs), we generated and analyzed Sox2-GFP transgenic mice...
  3. doi Hippocampal development and neural stem cell maintenance require Sox2-dependent regulation of Shh
    Rebecca Favaro
    Department of Biotechnology and Biosciences, University of Milano Bicocca, Milano, Italy
    Nat Neurosci 12:1248-56. 2009
    Neural stem cells (NSCs) are controlled by diffusible factors. The transcription factor Sox2 is expressed by NSCs and Sox2 mutations in humans cause defects in the brain and, in particular, in the hippocampus...
  4. pmc SOX2 is a dose-dependent regulator of retinal neural progenitor competence
    Olena V Taranova
    Department of Genetics, University of North Carolina at Chapel Hill, NC 27599, USA
    Genes Dev 20:1187-202. 2006
    ..with anophthalmia (absent eye) or severe microphthalmia (small eye) show haploid insufficiency due to mutations in SOX2, a SOXB1-HMG box transcription factor...
  5. ncbi Sox2 is required for sensory organ development in the mammalian inner ear
    Amy E Kiernan
    MRC Institute of Hearing Research, University of Nottingham, Nottingham NG7 2RD, UK
    Nature 434:1031-5. 2005
    ..are due to the absence (in Lcc mutants) or reduced expression (in Ysb mutants) of the transcription factor SOX2, specifically within the developing inner ear...
  6. ncbi Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4
    J Nichols
    Centre for Genome Research, University of Edinburgh, United Kingdom
    Cell 95:379-91. 1998
    ..Expansion of trophoblast precursors is restored, however, by an Oct4 target gene product, fibroblast growth factor-4. Therefore, Oct4 also determines paracrine growth factor signaling from stem cells to the trophectoderm...
  7. pmc Sox2(+) adult stem and progenitor cells are important for tissue regeneration and survival of mice
    Katrin Arnold
    Howard Hughes Medical Institute and Department of Stem Cell and Regenerative Biology, Harvard University and Harvard Medical School, Cambridge, MA 02138, USA
    Cell Stem Cell 9:317-29. 2011
    The transcription factor Sox2 maintains the pluripotency of early embryonic cells and regulates the formation of several epithelia during fetal development. Whether Sox2 continues to play a role in adult tissues remains largely unknown...
  8. pmc Analysis of congenital hypomyelinating Egr2Lo/Lo nerves identifies Sox2 as an inhibitor of Schwann cell differentiation and myelination
    Nam Le
    Department of Pathology and Immunology, Washington University School of Medicine, 660 South Euclid Avenue, Box 8118, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 102:2596-601. 2005
    ..One of the abnormally elevated genes in Egr2Lo/Lo Schwann cells, Sox2, encodes a transcription factor that is crucial for maintenance of neural stem cell pluripotency...
  9. ncbi Role of Sox2 in the development of the mouse neocortex
    Mahmud Bani-Yaghoub
    Neurogenesis and Brain Repair Group, Neurobiology Program, Institute for Biological Sciences, National Research Council of Canada, 1200 Montreal Rd, Bldg M 54, Ottawa, ON, Canada K1A 0R6
    Dev Biol 295:52-66. 2006
    ..Here, we examined the mechanism of Sox2 action during neocortical neurogenesis and gliogenesis...
  10. doi Consequence of the loss of Sox2 in the developing brain of the mouse
    Satoru Miyagi
    Division of Developmental Biology, Research Center for Genomic Medicine, Saitama Medical University, 1397 1 Yamane, Hidaka, Saitama 350 1241, Japan
    FEBS Lett 582:2811-5. 2008
    The transcription factor Sox2 is expressed at high levels in neural stem and progenitor cells. Here, we inactivated Sox2 specifically in the developing brain by using Cre-loxP system...
  11. pmc Interplay of SOX and POU factors in regulation of the Nestin gene in neural primordial cells
    Shinya Tanaka
    Graduate School of Frontier Biosciences, Osaka University, 1 3 Yamadaoka, Suita, Osaka 565 0871, Japan
    Mol Cell Biol 24:8834-46. 2004
    ..Evidence also suggests that such interactions are involved in the regulation of neural primordial cells...
  12. pmc The Sox-2 regulatory regions display their activities in two distinct types of multipotent stem cells
    Satoru Miyagi
    Division of Developmental Biology, Research Center for Genomic Medicine, Saitama Medical School, Saitama 350 1241, Japan
    Mol Cell Biol 24:4207-20. 2004
    ..Thus, SRR2 is the first example of an enhancer in which a single regulatory core sequence is involved in multipotent-state-specific expression in two different stem cells, i.e., ES and neural stem cells...
  13. pmc The Notch ligand JAG1 is required for sensory progenitor development in the mammalian inner ear
    Amy E Kiernan
    The Jackson Laboratory, Bar Harbor, Maine, USA
    PLoS Genet 2:e4. 2006
    ..The saccular macula is present but malformed. Using SOX2 and p27kip1 as molecular markers of the prosensory domain, we show that JAG1 is initially expressed in all the ..
  14. ncbi The Sox2 regulatory region 2 functions as a neural stem cell-specific enhancer in the telencephalon
    Satoru Miyagi
    Division of Developmental Biology, Research Center for Genomic Medicine, Saitama Medical University, 1397 1 Yamane, Hidaka, Saitama 350 1241, Japan
    J Biol Chem 281:13374-81. 2006
    b>Sox2 is expressed at high levels in neuroepithelial stem cells and persists in neural stem/progenitor cells throughout adulthood. We showed previously that the Sox2 regulatory region 2 (SRR2) drives strong expression in these cells...
  15. pmc Complex architecture and regulated expression of the Sox2ot locus during vertebrate development
    Paulo P Amaral
    ARC Special Research Centre for Functional and Applied Genomics, Institute for Molecular Bioscience, The University of Queensland, St Lucia, QLD 4072, Australia
    RNA 15:2013-27. 2009
    The Sox2 gene is a key regulator of pluripotency embedded within an intron of a long noncoding RNA (ncRNA), termed Sox2 overlapping transcript (Sox2ot), which is transcribed in the same orientation...
  16. doi Small increases in the level of Sox2 trigger the differentiation of mouse embryonic stem cells
    Janel L Kopp
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska, USA
    Stem Cells 26:903-11. 2008
    Previous studies have demonstrated that the transcription factor Sox2 is essential during the early stages of development...
  17. pmc Combinatorial regulation of optic cup progenitor cell fate by SOX2 and PAX6
    Danielle Matsushima
    UNC Neuroscience Center, University of North Carolina at Chapel Hill, NC 27599, USA
    Development 138:443-54. 2011
    In humans, haploinsufficiency of either SOX2 or PAX6 is associated with microphthalmia, anophthalmia or aniridia...
  18. ncbi A comparison of the properties of Sox-3 with Sry and two related genes, Sox-1 and Sox-2
    J Collignon
    Laboratory of Developmental Genetics, MRC National Institute for Medical Research, London, UK
    Development 122:509-20. 1996
    ..However our findings imply that if this is true, then Sry has undergone concomitant changes resulting in loss of CNS expression and altered DNA-binding properties...
  19. doi Sox2 cooperates with Chd7 to regulate genes that are mutated in human syndromes
    Erik Engelen
    Department of Cell Biology, Erasmus Medical Center MC, Rotterdam, The Netherlands
    Nat Genet 43:607-11. 2011
    The HMG-box transcription factor Sox2 plays a role throughout neurogenesis and also acts at other stages of development, as illustrated by the multiple organs affected in the anophthalmia syndrome caused by SOX2 mutations...
  20. pmc BMP4 is essential for lens induction in the mouse embryo
    Y Furuta
    Howard Hughes Medical Institute and Department of Cell Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2175 USA
    Genes Dev 12:3764-75. 1998
    ..This is associated with rescue of ectodermal expression of Sox2, an early lens placode marker...
  21. pmc Crystal structure of a POU/HMG/DNA ternary complex suggests differential assembly of Oct4 and Sox2 on two enhancers
    Attila Remenyi
    Gene Expression Program, EMBL, 69117 Heidelberg, Germany
    Genes Dev 17:2048-59. 2003
    ..In this study, we focus on two transcription factors, Oct4 and Sox2, as their combination on DNA is considered to direct the establishment of the first three lineages in the mammalian ..
  22. pmc Reciprocal transcriptional regulation of Pou5f1 and Sox2 via the Oct4/Sox2 complex in embryonic stem cells
    Joon Lin Chew
    Department of Biological Sciences, National University of Singapore
    Mol Cell Biol 25:6031-46. 2005
    ..Oct4 and Sox2 are transcription factors essential to the pluripotent and self-renewing phenotypes of ESCs...
  23. pmc beta-Catenin promotes respiratory progenitor identity in mouse foregut
    Kelley S Harris-Johnson
    Laboratory of Genetics and Division of Pharmaceutical Sciences, University of Wisconsin Madison, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 106:16287-92. 2009
    ..Our findings reveal an early role for beta-Catenin in the establishment of respiratory progenitors in mouse foregut endoderm...
  24. pmc The transcription factor Sox2 is required for osteoblast self-renewal
    U Basu-Roy
    Department of Microbiology, NYU School of Medicine, New York, NY, USA
    Cell Death Differ 17:1345-53. 2010
    ..The transcription factor Sox2 is essential for embryonic development and maintains pluripotency and self-renewal in embryonic stem cells...
  25. pmc Suppression of the novel ER protein Maxer by mutant ataxin-1 in Bergman glia contributes to non-cell-autonomous toxicity
    Hiroki Shiwaku
    Department of Neuropathology, Medical Research Institute, Tokyo Medical and Dental University, Bunkyo ku, Tokyo, Japan
    EMBO J 29:2446-60. 2010
    ..Collectively, these results suggest that the reduction of Maxer mediates functional deficiency of Bergmann glia, and might contribute to the non-cell-autonomous pathology of SCA1...
  26. pmc Sox17 and Sox4 differentially regulate beta-catenin/T-cell factor activity and proliferation of colon carcinoma cells
    Debora Sinner
    Division of Developmental Biology, Cincinnati Children s Hospital Research Foundation, 3333 Burnet Avenue, Cincinnati, Ohio 45229 3039, USA
    Mol Cell Biol 27:7802-15. 2007
    ..These findings indicate that Sox proteins can act as both antagonists and agonists of beta-catenin/TCF activity, and this mechanism may regulate Wnt signaling responses in many developmental and disease contexts...
  27. doi Impaired generation of mature neurons by neural stem cells from hypomorphic Sox2 mutants
    Maurizio Cavallaro
    Dipartimento di Biotecnologie e Bioscienze, Universita di Milano Bicocca, Piazza della Scienza 2, 20126 Milano, Italy
    Development 135:541-57. 2008
    The transcription factor Sox2 is active in neural stem cells, and Sox2 'knockdown' mice show defects in neural stem/progenitor cells in the hippocampus and eye, and possibly some neurons...
  28. pmc Fgf20 is required for sensory epithelial specification in the developing cochlea
    Toshinori Hayashi
    Virginia Merrill Bloedel Hearing Research Center and Department of Biological Structure, University of Washington, Seattle, Washington 98195, USA
    J Neurosci 28:5991-9. 2008
    ..Our results thus define the period of FGF-dependent sensory cell specification and the ligand that mediates this step in cochlear development...
  29. doi Acetylation of sox2 induces its nuclear export in embryonic stem cells
    Gretchen A Baltus
    Developmental and Molecular Pathways, Novartis Institute of Biomedical Research, Cambridge, Massachusetts 02139, USA
    Stem Cells 27:2175-84. 2009
    ..Central to these processes are the proteins Oct4, Nanog, and Sox2. Although the transcriptional targets of these factors have been extensively studied, very little is known about ..
  30. pmc Stage-dependent modes of Pax6-Sox2 epistasis regulate lens development and eye morphogenesis
    April N Smith
    Division of Pediatric Ophthalmology, Cincinnati Children s Hospital Research Foundation, Cincinnati, OH 45229, USA
    Development 136:2977-85. 2009
    The transcription factors Pax6 and Sox2 have been implicated in early events in lens induction and have been proposed to cooperate functionally...
  31. doi Selection of differentiating cells by different levels of delta-like 1 among neural precursor cells in the developing mouse telencephalon
    Daichi Kawaguchi
    Institute of Molecular and Cellular Biosciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    Development 135:3849-58. 2008
    ....
  32. ncbi SOX2, a persistent marker for multipotential neural stem cells derived from embryonic stem cells, the embryo or the adult
    Pam Ellis
    Neuroscience Center, Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA
    Dev Neurosci 26:148-65. 2004
    ..We show that SOX2, an HMG box transcription factor, is expressed in multipotent neural stem cells at all stages of mouse ontogeny...
  33. ncbi Developmental-specific activity of the FGF-4 enhancer requires the synergistic action of Sox2 and Oct-3
    H Yuan
    Department of Microbiology, New York University School of Medicine, New York 10016, USA
    Genes Dev 9:2635-45. 1995
    ..Through the cloning and characterization of an F9 cell cDNA we now show that the latter activity is Sox2, a member of the Sry-related Sox factors family...
  34. pmc Pax6 activity in the lens primordium is required for lens formation and for correct placement of a single retina in the eye
    R Ashery-Padan
    Max Planck Institute of Biophysical Chemistry, Department of Molecular Cell Biology, Goettingen D 37077, Germany
    Genes Dev 14:2701-11. 2000
    ..Although lens induction occurred in the mutant, as indicated by Sox2 up-regulation in the surface ectoderm, further development of the lens was arrested...
  35. ncbi Nmyc plays an essential role during lung development as a dosage-sensitive regulator of progenitor cell proliferation and differentiation
    Tadashi Okubo
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Development 132:1363-74. 2005
    ..We propose a model in which Nmyc is essential in the developing lung for maintaining a distal population of undifferentiated, proliferating progenitor cells...
  36. pmc Murine inner cell mass-derived lineages depend on Sall4 function
    Ulrich Elling
    Developmental Biology Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Proc Natl Acad Sci U S A 103:16319-24. 2006
    ..expressed by cells of the early embryo and germ cells, an expression pattern similar to that of both Oct4 and Sox2, which play essential roles during early murine development...
  37. pmc Foxg1 promotes olfactory neurogenesis by antagonizing Gdf11
    Shimako Kawauchi
    Department of Anatomy and Neurobiology, University of California, Irvine, CA 92697, USA
    Development 136:1453-64. 2009
    ..Thus, the pro-neurogenic effects of Foxg1 are likely to be mediated through different signaling pathways in different parts of the nervous system...
  38. pmc Cyclin D1 fine-tunes the neurogenic output of embryonic retinal progenitor cells
    Gaurav Das
    Department of Ophthalmology and Visual Sciences, John A Moran Eye Center, University of Utah, Salt Lake City, UT 84132, USA
    Neural Dev 4:15. 2009
    ..How cyclin D1 influences RPC behavior, especially during the embryonic period, is unclear...
  39. pmc Acheate-scute like 1 (Ascl1) is required for normal delta-like (Dll) gene expression and notch signaling during retinal development
    Branden R Nelson
    Department of Biological Structure, School of Medicine, University of Washington, Seattle, Washington 98195, USA
    Dev Dyn 238:2163-78. 2009
    ..Thus, these results suggest a molecular mechanism whereby attenuated Notch levels coupled with reduced proneurogenic activity in progenitors leads to increased gliogenesis and decreased neurogenesis in the Ascl1-deficient retina...
  40. pmc A role for FE65 in controlling GnRH-1 neurogenesis
    Paolo E Forni
    Cellular and Developmental Neurobiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 31:480-91. 2011
    ....
  41. pmc Sox1 directly regulates the gamma-crystallin genes and is essential for lens development in mice
    S Nishiguchi
    Laboratory of Embryology, Medical Research Council MRC Clinical Sciences Centre, Hammersmith Hospital, London W12 0NN, UK
    Genes Dev 12:776-81. 1998
    ..It appears that the direct interaction of the SOX1 protein with a promoter element conserved in all gamma-crystallin genes is responsible for their expression...
  42. pmc Sox2 is required for development of taste bud sensory cells
    Tadashi Okubo
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Genes Dev 20:2654-9. 2006
    b>Sox2 is expressed in basal epithelial cells of the tongue, with high levels in taste bud placodes, fungiform papillae, and mature taste cells, and low levels in filiform papillae...
  43. pmc Redundant roles of Tead1 and Tead2 in notochord development and the regulation of cell proliferation and survival
    Atsushi Sawada
    Laboratory for Embryonic Induction, RIKEN Center for Developmental Biology, 2 2 3 Minatojima minamimachi, Chuo Ku, Kobe, Hyogo 650 0047, Japan
    Mol Cell Biol 28:3177-89. 2008
    ..These results suggest that Tead1 and Tead2 are functionally redundant, use YAP as a major coactivator, and support notochord maintenance as well as cell proliferation and survival in mouse development...
  44. doi The structure of Sox17 bound to DNA reveals a conserved bending topology but selective protein interaction platforms
    Paaventhan Palasingam
    Laboratory of Structural Biochemistry, Genome Institute of Singapore, 60 Biopolis Street, Singapore, Singapore
    J Mol Biol 388:619-30. 2009
    ..regulates endodermal lineage commitment and is thought to function antagonistically to the pluripotency determinant Sox2. To investigate the biochemical basis for the distinct functions of Sox2 and Sox17, we solved the crystal structure ..
  45. pmc Follistatin modulates a BMP autoregulatory loop to control the size and patterning of sensory domains in the developing tongue
    Crestina L Beites
    Department of Anatomy and Neurobiology and Center for Complex Biological Systems, University of California, Irvine, CA 92697, USA
    Development 136:2187-97. 2009
    ..FST limits expansion and differentiation of Sox2-expressing taste progenitor cells and negatively regulates the development of taste papillae in the lingual ..
  46. pmc From head to toes: the multiple facets of Sox proteins
    M Wegner
    Zentrum für Molekulare Neurobiologie, Universitat Hamburg, Martinistrasse 52, D 20246 Hamburg, Germany
    Nucleic Acids Res 27:1409-20. 1999
    ..Sox proteins perform their function in a complex interplay with other transcription factors in a manner highly dependent on cell type and promoter context. They exhibit a remarkable crosstalk and functional redundancy among each other...
  47. ncbi Isolation, characterization, and differential expression of the murine Sox-2 promoter
    M S Wiebe
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198 6805, USA
    Gene 246:383-93. 2000
    ..Mutagenesis of this site significantly reduces the expression of Sox-2 promoter/reporter constructs. We also demonstrate that this CCAAT box motif can bind the trimeric transcription factor NF-Y...
  48. pmc Mice lacking ZFHX1B, the gene that codes for Smad-interacting protein-1, reveal a role for multiple neural crest cell defects in the etiology of Hirschsprung disease-mental retardation syndrome
    Tom Van de Putte
    Department of Developmental Biology, Flanders Interuniversity Institute for Biotechnology, and Laboratory of Molecular Biology Celgen, University of Leuven, Leuven, Belgium
    Am J Hum Genet 72:465-70. 2003
    ..Furthermore, we show that Sip1 is involved in the specification of neuroepithelium...
  49. pmc Fbx15 is a novel target of Oct3/4 but is dispensable for embryonic stem cell self-renewal and mouse development
    Yoshimi Tokuzawa
    Laboratory of Animal Molecular Technology, Research and Education Center for Genetic Information, Nara Institute of Science and Technology, Ikoma, Nara 630 0192, Japan
    Mol Cell Biol 23:2699-708. 2003
    ..The 18-bp fragment became active in NIH 3T3 cells when Oct3/4 and Sox2 were coexpressed...
  50. ncbi Oct-3/4 and Sox2 regulate Oct-3/4 gene in embryonic stem cells
    Sayaka Okumura-Nakanishi
    Laboratory of Molecular and Cellular Assembly, Department of Biological Information, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, 4259 Nagatuda, Midori ku, Yokohama 226 8501, Japan
    J Biol Chem 280:5307-17. 2005
    ..In an electrophoretic mobility shift assay we showed that Site 2B specifically binds to Oct-3/4 and Sox2 when ES-derived cell extracts were used, whereas Site 2A binds to a factor(s) present in both ES and NIH 3T3 cells...
  51. ncbi Mutations in SOX2 cause anophthalmia-esophageal-genital (AEG) syndrome
    Kathleen A Williamson
    Medical Genetics Section, MRC Human Genetics Unit, Western General Hospital, Edinburgh EH4 2XU, UK
    Hum Mol Genet 15:1413-22. 2006
    We report heterozygous, loss-of-function SOX2 mutations in three unrelated individuals with Anophthalmia-Esophageal-Genital (AEG) syndrome. One previously reported case [Rogers, R.C. (1988) Unknown cases...
  52. pmc Mutations within Sox2/SOX2 are associated with abnormalities in the hypothalamo-pituitary-gonadal axis in mice and humans
    Daniel Kelberman
    London Centre for Paediatric Endocrinology, Biochemistry, Endocrinology, Institute of Child Health, University College London, London, United Kingdom
    J Clin Invest 116:2442-55. 2006
    The transcription factor SOX2 is expressed most notably in the developing CNS and placodes, where it plays critical roles in embryogenesis...
  53. pmc Klf4 cooperates with Oct3/4 and Sox2 to activate the Lefty1 core promoter in embryonic stem cells
    Yuhki Nakatake
    Laboratory for Pluripotent Cell Studies, RIKEN Center for Developmental Biology, Minatojima minamimachi 2 2 3, Chu o ku, Kobe 650 0047, Japan
    Mol Cell Biol 26:7772-82. 2006
    ..identified an ES cell-specific enhancer upstream of the Lefty1 promoter that contains binding sites for Oct3/4 and Sox2. Unlike other known Oct3/4-Sox2-dependent enhancers, however, this enhancer element could not be activated by Oct3/..
  54. ncbi A dominant-negative form of mouse SOX2 induces trophectoderm differentiation and progressive polyploidy in mouse embryonic stem cells
    Jun Li
    Institute of Pharmacology, Department of Biological Sciences and Biotechnology, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institutes of Biomedicine, School of Medicine, Tsinghua University, Beijing 100084, China
    J Biol Chem 282:19481-92. 2007
    b>SOX2 plays an important role in early embryogenesis by cooperating with OCT4 in regulating gene expression in fertilized eggs, yet the precise mechanism through which SOX2 accomplishes this important function remains poorly understood...
  55. ncbi Pluripotency governed by Sox2 via regulation of Oct3/4 expression in mouse embryonic stem cells
    Shinji Masui
    Laboratory for Pluripotent Cell Studies, RIKEN Center for Developmental Biology, Minatojima minamimachi 2 2 3, Chu o ku, Kobe, Hyogo 650 0047, Japan
    Nat Cell Biol 9:625-35. 2007
    ..of embryonic stem (ES) cells is thought to be maintained by a few key transcription factors, including Oct3/4 and Sox2. The function of Oct3/4 in ES cells has been extensively characterized, but that of Sox2 has yet to be determined...
  56. pmc Multiple dose-dependent roles for Sox2 in the patterning and differentiation of anterior foregut endoderm
    Jianwen Que
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Development 134:2521-31. 2007
    b>Sox2 is expressed in developing foregut endoderm, with highest levels in the future esophagus and anterior stomach. By contrast, Nkx2.1 (Titf1) is expressed ventrally, in the future trachea...
  57. ncbi Hypomorphic Sox10 alleles reveal novel protein functions and unravel developmental differences in glial lineages
    Silke Schreiner
    Institut fur Biochemie, Emil Fischer Zentrum, Universitat Erlangen, Fahrstrasse 17, D 91054 Erlangen, Germany
    Development 134:3271-81. 2007
    ....
  58. ncbi Six1 is essential for early neurogenesis in the development of olfactory epithelium
    Keiko Ikeda
    Division of Biology, Center for Molecular Medicine, Jichi Medical University, Shimotsuke, Tochigi 329 0498, Japan
    Dev Biol 311:53-68. 2007
    ..Our study indicates that Six1 plays critical roles in early neurogenesis by regulating Ngn1, NeuroD, Hes1, and Hes5...
  59. pmc Sox2 signaling in prosensory domain specification and subsequent hair cell differentiation in the developing cochlea
    Alain Dabdoub
    Section on Developmental Neuroscience, NIDCD, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 105:18396-401. 2008
    b>Sox2 is a high-mobility transcription factor that is one of the earliest markers of developing inner ear prosensory domains...
  60. doi Initiation of olfactory placode development and neurogenesis is blocked in mice lacking both Six1 and Six4
    Binglai Chen
    Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine of NYU, New York, NY 10029, USA
    Dev Biol 326:75-85. 2009
    ..5 and it overlaps with Sox2 expression. Both genes are expressed in the basal and apical neuronal progenitors in the OE...
  61. doi Canonical Notch signaling is not required for the growth of Hedgehog pathway-induced medulloblastoma
    E Julian
    Institute for Molecular Bioscience, University of Queensland, Brisbane, Australia
    Oncogene 29:3465-76. 2010
    ..Hedgehog-dependent medulloblastoma were not blocked by loss of RBP-J, indicating that canonical Notch signaling is not required for tumor initiation and growth in this model...
  62. pmc Involvement of SOX proteins in lens-specific activation of crystallin genes
    Y Kamachi
    Institute for Molecular and Cellular Biology, Osaka University, Japan
    EMBO J 14:3510-9. 1995
    ..This work is the first to show delta- and gamma-crystallin genes as examples of direct regulatory targets of SOX proteins and provides evidence that diversified crystallin genes are regulated, at least partly, by a common mechanism...
  63. ncbi Involvement of Sox1, 2 and 3 in the early and subsequent molecular events of lens induction
    Y Kamachi
    Institute for Molecular and Cellular Biology, Osaka University, Suita, Osaka 565 0871, Japan
    Development 125:2521-32. 1998
    ..One of the deltaEF2 factors was previously identified as SOX2. We show that two related SOX proteins, SOX1 and SOX3, account for the remaining members of deltaEF2...
  64. ncbi BMP7 acts in murine lens placode development
    S Wawersik
    Division of Genetics, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, 02115, USA
    Dev Biol 207:176-88. 1999
    ..We conclude that Bmp7 is a critical component of the genetic mechanism(s) controlling lens placode formation...
  65. ncbi Comparative expression of the mouse Sox1, Sox2 and Sox3 genes from pre-gastrulation to early somite stages
    H B Wood
    Mammalian Neurogenesis Group, Medical Research Council MRC, Clinical Sciences Centre, Hammersmith Hospital, Du Cane Road, London, W12 0NN, UK
    Mech Dev 86:197-201. 1999
    ..mount in situ hybridisation was used to study the embryonic expression of the mouse HMG box-containing genes Sox1, Sox2 and Sox3 between 6.5 and 9.0 days post coitum (dpc)...
  66. ncbi Sox2 regulatory sequences direct expression of a (beta)-geo transgene to telencephalic neural stem cells and precursors of the mouse embryo, revealing regionalization of gene expression in CNS stem cells
    M V Zappone
    Dipartimento di Genetica e di Biologia dei Microrganismi, Universita di Milano, via L Celoria 26, Italy
    Development 127:2367-82. 2000
    b>Sox2 is one of the earliest known transcription factors expressed in the developing neural tube...
  67. ncbi Fgf receptor signaling plays a role in lens induction
    S C Faber
    Skirball Institute for Biomolecular Medicine, Developmental Genetics Program, Cell Biology Department, New York University Medical Center, 540 First Avenue, New York, NY 10016, USA
    Development 128:4425-38. 2001
    ..5 but in addition, showed reduced levels of expression for Pax6, Sox2 and Foxe3, all markers of lens induction; (3) by performing crosses between Tfr7 transgenic and Bmp7-null mice, we ..
  68. ncbi Sox2 deficiency causes neurodegeneration and impaired neurogenesis in the adult mouse brain
    Anna L M Ferri
    Department of Biotechnology and Biosciences, University of Milano Bicocca, Piazza della Scienza 2, 20126 Milano, Italy
    Development 131:3805-19. 2004
    In many species, the Sox2 transcription factor is a marker of the nervous system from the beginning of its development, and we have previously shown that Sox2 is expressed in embryonic neural stem cells...
  69. ncbi Conserved POU binding DNA sites in the Sox2 upstream enhancer regulate gene expression in embryonic and neural stem cells
    Raffaella Catena
    Department of Biotechnology and Biosciences, University of Milano Bicocca, Piazza della Scienza 2, Milano 20126, Italy
    J Biol Chem 279:41846-57. 2004
    The Sox2 transcription factor is expressed early in the stem cells of the blastocyst inner cell mass and, later, in neural stem cells...
  70. pmc Sox2 induction by FGF and FGFR2 activating mutations inhibits Wnt signaling and osteoblast differentiation
    Alka Mansukhani
    Department of Microbiology, New York University School of Medicine, New York, NY 10016, USA
    J Cell Biol 168:1065-76. 2005
    ..down-regulation of the expression of many Wnt target genes and a concomitant induction of the transcription factor Sox2. Most of these changes could be reproduced by treatment of osteoblasts with exogenous FGF...
  71. ncbi Transcriptional regulation of nanog by OCT4 and SOX2
    David J Rodda
    Stem Cell and Developmental Biology and Gene Regulation Laboratory, Genome Institute of Singapore, Singapore 138672
    J Biol Chem 280:24731-7. 2005
    Nanog, Sox2, and Oct4 are transcription factors all essential to maintaining the pluripotent embryonic stem cell phenotype...
  72. ncbi Impact of transcription factor Sox8 on oligodendrocyte specification in the mouse embryonic spinal cord
    C Claus Stolt
    Institut fur Biochemie, Universitat Erlangen Nurnberg, Fahrstrasse 17, 91054 Erlangen, Germany
    Dev Biol 281:309-17. 2005
    ..Oligodendrocyte development thus relies on the differential contribution of all three group E Sox proteins at various phases...
  73. pmc Olig2+ neuroepithelial motoneuron progenitors are not multipotent stem cells in vivo
    Yoh suke Mukouyama
    Howard Hughes Medical Institute and Division of Biology 216 76, California Institute of Technology, 1201 East California Boulevard, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 103:1551-6. 2006
    ..These results do not support the commonly held view that most neuroepithelial cells in the embryonic CNS VZ are stem cells in vivo...
  74. ncbi Regulation of the pluripotency marker Rex-1 by Nanog and Sox2
    Wenjing Shi
    Institute of Pharmacology, Department of Biological Sciences and Biotechnology, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institutes of Biomedicine, School of Medicine, Tsinghua University, Beijing 100084, China
    J Biol Chem 281:23319-25. 2006
    ..Although Oct-3/4 and Sox2 can both transactivate Rex-1 promoter, only Sox2 cooperates with Nanog in up-regulating Rex-1...
  75. ncbi Dissecting self-renewal in stem cells with RNA interference
    Natalia Ivanova
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA
    Nature 442:533-8. 2006
    ..Our studies suggest specific biological roles for these molecules and reveal the complexity of cell fate regulation in embryonic stem cells...
  76. pmc Six3 activation of Pax6 expression is essential for mammalian lens induction and specification
    Wei Liu
    Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    EMBO J 25:5383-95. 2006
    ..In Six3-mutant embryos, Pax6 was downregulated, and Sox2 was absent in the lens preplacodal ectoderm...
  77. pmc Sox2 and Pou2f1 interact to control lens and olfactory placode development
    Amy L Donner
    Division of Genetics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Dev Biol 303:784-99. 2007
    b>Sox2, which encodes an SRY-like HMG box transcription factor, is critical for vertebrate development. Sox2 mediates its transcriptional effects through the formation of complexes with specific co-factors, many of which are unknown...
  78. ncbi SOX3 activity during pharyngeal segmentation is required for craniofacial morphogenesis
    Karine Rizzoti
    Division of Developmental Genetics, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Development 134:3437-48. 2007
    ..We also show that Sox3 genetically interacts both with FgfR1 and with Sox2, another member of the Soxb1 family, to fulfil its function in the pharyngeal region...
  79. ncbi Independent functions and mechanisms for homeobox gene Barx1 in patterning mouse stomach and spleen
    Byeong Moo Kim
    Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Development 134:3603-13. 2007
    ..These observations place Barx1 proximally within a Wt1 pathway of spleen development and reveal how a homeotic regulator employs different molecular mechanisms to mold neighboring organs...
  80. ncbi Tead4 is required for specification of trophectoderm in pre-implantation mouse embryos
    Noriyuki Nishioka
    Laboratory for Embryonic Induction, RIKEN Center for Developmental Biology, 2 2 3 Minatojima minamimachi, Chuo, Kobe, Hyogo 650 0047, Japan
    Mech Dev 125:270-83. 2008
    ....
  81. pmc Bmp4 is essential for the formation of the vestibular apparatus that detects angular head movements
    Weise Chang
    National Institute on Deafness and Other Communication Disorders, NIH, Rockville, Maryland, United States of America
    PLoS Genet 4:e1000050. 2008
    ..genes required for prosensory development in the inner ear such as Serrate1 (Jagged1 in mouse), Fgf10, and Sox2. Instead, Bmp4 most likely mediates crista formation by regulating Lmo4 and Msx1 in the sensory region and Gata3, ..
  82. doi Nanog and Oct4 associate with unique transcriptional repression complexes in embryonic stem cells
    Jiancong Liang
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Nat Cell Biol 10:731-9. 2008
    ..Our data collectively suggest that Nanog and Oct4 associate with unique repressor complexes on their target genes to control ES cell fate...
  83. doi Reprogramming of neural progenitor cells into induced pluripotent stem cells in the absence of exogenous Sox2 expression
    Sarah Eminli
    Massachusetts General Hospital Cancer Center and Center for Regenerative Medicine, Boston, Massachusetts 02114, USA
    Stem Cells 26:2467-74. 2008
    Expression of the transcription factors Oct4, Sox2, Klf4, and c-Myc in mesodermal and endodermal derivatives, including fibroblasts, lymphocytes, liver, stomach, and beta cells, generates induced pluripotent stem (iPS) cells...
  84. pmc Eya1 gene dosage critically affects the development of sensory epithelia in the mammalian inner ear
    Dan Zou
    McLaughlin Research Institute for Biomedical Sciences, Great Falls, MT 59405, USA
    Hum Mol Genet 17:3340-56. 2008
    ..Furthermore, we show that Eya1 co-localizes with Sox2 in the sensory progenitors and both proteins physically interact...
  85. doi Gli2 is a novel regulator of sox2 expression in telencephalic neuroepithelial cells
    Hiromi Takanaga
    Center for Developmental Biology, RIKEN, Kobe, Japan
    Stem Cells 27:165-74. 2009
    ..We show here that the expression of sox2 gene, which is essential for the maintenance of NSCs, is regulated by the Gli2 transcription factor, a downstream ..
  86. pmc Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3beta/beta-catenin signaling
    Yingwei Mao
    Howard Hughes Medical Institute, Cambridge, MA 02139, USA
    Cell 136:1017-31. 2009
    ..Together, these results implicate DISC1 in GSK3beta/beta-catenin signaling pathways and provide a framework for understanding how alterations in this pathway may contribute to the etiology of psychiatric disorders...
  87. pmc Multiple roles for Sox2 in the developing and adult mouse trachea
    Jianwen Que
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Development 136:1899-907. 2009
    ..Previously, we demonstrated that the transcription factor Sox2 is necessary for foregut morphogenesis and esophagus development...
  88. pmc PARP1 poly(ADP-ribosyl)ates Sox2 to control Sox2 protein levels and FGF4 expression during embryonic stem cell differentiation
    Furong Gao
    Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Chinese Academy of Sciences Shanghai JiaoTong University School of Medicine, Shanghai 200025, China
    J Biol Chem 284:22263-73. 2009
    Transcription factors Oct4 and Sox2 are key players in maintaining the pluripotent state of embryonic stem cells (ESCs). Small changes in their levels disrupt normal expression of their target genes...
  89. pmc Pax6 is essential for lens fiber cell differentiation
    Ohad Shaham
    Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Development 136:2567-78. 2009
    ..Although the transcription factors Pax6 and Sox2 have been shown to be essential for lens induction, their later roles during lens fiber differentiation remain ..
  90. pmc Wnt-mediated activation of NeuroD1 and retro-elements during adult neurogenesis
    Tomoko Kuwabara
    National Institute of Advanced Industrial Science and Technology AIST, Tsukuba Science City, Japan
    Nat Neurosci 12:1097-105. 2009
    ..We found that Wnt signaling, together with the removal of Sox2, triggered the expression of NeuroD1 in mice...
  91. pmc FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis
    Ji Hye Paik
    Department of Medical Oncology, Belfer Institute for Applied Cancer Science, Harvard Medical School, Boston, MA 02115, USA
    Cell Stem Cell 5:540-53. 2009
    ..Thus, the FoxO family coordinately regulates diverse genes and pathways to govern key aspects of NSC homeostasis in the mammalian brain...
  92. pmc Sox2 is required for maintenance and differentiation of bronchiolar Clara, ciliated, and goblet cells
    David H Tompkins
    Division of Pulmonary Biology in the Perinatal Institute, Cincinnati Children s Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America
    PLoS ONE 4:e8248. 2009
    ..In the present work, we demonstrate that expression of Sox2 in Clara cells is required for the differentiation of ciliated, Clara, and goblet cells that line the bronchioles ..
  93. pmc Sox17 promotes differentiation in mouse embryonic stem cells by directly regulating extraembryonic gene expression and indirectly antagonizing self-renewal
    Kathy K Niakan
    Stowers Medical Institute, Harvard University, Cambridge, Massachusetts 02138, USA
    Genes Dev 24:312-26. 2010
    ..cell types and maintain expression of pluripotency-associated transcription factors, including Oct4, Nanog, and Sox2. In contrast, forced expression of Sox17 down-regulates ES cell-associated gene expression and directly activates ..
  94. pmc Expression patterns of FGF receptors in the developing mammalian cochlea
    Toshinori Hayashi
    Department of Biological Structure, Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, Washington 98109, USA
    Dev Dyn 239:1019-26. 2010
    ..We compare the receptor expression pattern to markers of the sensory domain (p27kip1) and the early hair cells (math1)...
  95. pmc COUP-TFs regulate eye development by controlling factors essential for optic vesicle morphogenesis
    Ke Tang
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, 77030, USA
    Development 137:725-34. 2010
    ..Taken together, our findings reveal novel and distinct cell-intrinsic mechanisms mediated by COUP-TF genes to direct the specification and differentiation of progenitor cells, and that COUP-TFs are crucial for dorsalization of the eye...
  96. pmc Temporal requirement of the protein tyrosine phosphatase Shp2 in establishing the neuronal fate in early retinal development
    Zhigang Cai
    Department of Medical and Molecular Genetics, Stark Neuroscience Institute, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Neurosci 30:4110-9. 2010
    ..Together, these results demonstrate that Shp2 mediates FGF-Ras signaling to control retinal progenitor cell fate...
  97. pmc Interactions of Wnt/beta-catenin signaling and sonic hedgehog regulate the neurogenesis of ventral midbrain dopamine neurons
    Mianzhi Tang
    Department of Pathology, University of California, San Francisco and Pathology Service, Veterans Affairs Medical Center, San Francisco, California 94121, USA
    J Neurosci 30:9280-91. 2010
    ..with region-specific activation of beta-catenin signaling in vMB using the Shh-Cre mice show a marked expansion of Sox2-, Ngn2-, and Otx2-positive progenitors but perturbs their cell cycle exit and reduces the generation of dopamine ..
  98. doi Epigenetic priming of a pre-B cell-specific enhancer through binding of Sox2 and Foxd3 at the ESC stage
    Daniel Liber
    MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College, Hammersmith Campus, Du Cane Road, London W12 0NN, UK
    Cell Stem Cell 7:114-26. 2010
    ..Here, we show that the ESC factor Sox2 targets H3K4 methylation to monovalent and bivalent domains...
  99. pmc Sox2 uses multiple domains to associate with proteins present in Sox2-protein complexes
    Jesse L Cox
    Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska, United States of America
    PLoS ONE 5:e15486. 2010
    Master regulators, such as Sox2, Oct4 and Nanog, control complex gene networks necessary for the self-renewal and pluripotency of embryonic stem cells (ESC)...
  100. pmc Regulation of male germ cell cycle arrest and differentiation by DND1 is modulated by genetic background
    Matthew S Cook
    Department of Cell Biology, Duke University, Durham, NC 27710, USA
    Development 138:23-32. 2011
    ..many mutant germ cells fail to enter mitotic arrest in G0 and do not downregulate the pluripotency markers NANOG, SOX2 and OCT4...
  101. pmc Conditional deletion of Atoh1 using Pax2-Cre results in viable mice without differentiated cochlear hair cells that have lost most of the organ of Corti
    Ning Pan
    University of Iowa, Department of Biology, 143 BB, Iowa City, IA 52242, USA
    Hear Res 275:66-80. 2011
    ..Afferents focus their projections on patches that express the prosensory specifying gene, Sox2. This pattern of innervation by sensory neurons is maintained at least until P14, but fibers target the few Myo7a ..

Research Grants11

  1. Excess TGF beta in neonatal lung injury and repair
    David Warburton; Fiscal Year: 2004
    ..abstract_text> ..
  2. Lung epithelial and vascular morphogenesis
    David Warburton; Fiscal Year: 2006
    ..abstract_text> ..
  3. MECHANISMS OF RAAV TRANSDUCTION IN THE AIRWAY
    JOHN ENGELHARDT; Fiscal Year: 2008
    ..Further elucidation of rAAV transduction biology in the airway will aid in the development of clinically applicable methods for increasing the efficacy of rAAV gene transfer in vivo. ..
  4. Redox-mediated NF-kappaB activation by LPS and IL-1
    JOHN ENGELHARDT; Fiscal Year: 2008
    ..Findings from these studies may lead to alternative therapeutic approaches targeting the liver by which to abrogate the detrimental effects of systemic cytokine production during sepsis. ..
  5. AUTOCRINE/PARACRINE GROWTH FACTORS & LUNG MORPHOGENESIS
    David Warburton; Fiscal Year: 2009
    ..Aim 4: To determine the role of tyrosine phosphorylation in protein-protein interaction and supra-molecular assembly of mSPRY2 with SHP2 and FRS2. Aim 5: To determine the functional importance of Shp2 in lung morphogenesis in vivo. ..
  6. DEVELOPMENTAL TYPE II PNEUMOCYTE PROTEIN PHOSPHORYLATION
    David Warburton; Fiscal Year: 2010
    ..Inosine may function as a low molecular weight therapeutic to ameliorate lung injury, protect lung progenitor cells and hence to promote recovery of the alveolar epithelium from acute injury in both adult and neonate. ..
  7. The function of Foxi3 in craniofacial development
    Takahiro Ohyama; Fiscal Year: 2008
    ..This project has significant potential for the future study of craniofacial and sensory organ development that will shed a light on the genetic mechanisms of craniofacial birth defects. ..
  8. Cell survival and cell death in the auditory nerve
    Hainan Lang; Fiscal Year: 2008
    ..abstract_text> ..
  9. Afferent Innervation of the Postnatal Cochlea
    CLIFFORD HUME; Fiscal Year: 2008
    ..Finally, I will use molecular techniques to begin to dissect the signals that regulate axon guidance in the developing auditory system. ..
  10. DISSECTING THE EAR NEUROSENSORY DEVELOPMENT.
    Bernd Fritzsch; Fiscal Year: 2010
    ..Such information is crucial to govern the use of neurotrophins for regeneration, plasticity and maintenance of adult innervation. ..