Socs3

Summary

Gene Symbol: Socs3
Description: suppressor of cytokine signaling 3
Alias: Cis3, Cish3, EF-10, Ef10, SSI-3, Ssi3, suppressor of cytokine signaling 3, CIS-3, E2a-Pbx1 target gene in fibroblasts 10, STAT-induced STAT inhibitor 3, cytokine inducible SH2-containing protein 3
Species: mouse

Top Publications

  1. ncbi The N-terminal truncated isoform of SOCS3 translated from an alternative initiation AUG codon under stress conditions is stable due to the lack of a major ubiquitination site, Lys-6
    Atsuo Sasaki
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    J Biol Chem 278:2432-6. 2003
  2. ncbi Pim-1 kinase inhibits STAT5-dependent transcription via its interactions with SOCS1 and SOCS3
    Katriina J Peltola
    Turku Centre for Biotechnology, University of Turku Abo Akademi University, Turku, Finland
    Blood 103:3744-50. 2004
  3. ncbi Deletion of the SOCS3 gene in liver parenchymal cells promotes hepatitis-induced hepatocarcinogenesis
    Hisanobu Ogata
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Graduate School of Medical Science, Kyushu University, Higashiku, Fukuoka, Japan
    Gastroenterology 131:179-93. 2006
  4. ncbi Loss of SOCS3 gene expression converts STAT3 function from anti-apoptotic to pro-apoptotic
    Yang Lu
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    J Biol Chem 281:36683-90. 2006
  5. ncbi SOCS3 is required to temporally fine-tune photoreceptor cell differentiation
    Yoko Ozawa
    Department of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Dev Biol 303:591-600. 2007
  6. ncbi SOCS3 regulates the plasticity of gp130 signaling
    Roland Lang
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Nat Immunol 4:546-50. 2003
  7. ncbi CIS3/SOCS-3 suppresses erythropoietin (EPO) signaling by binding the EPO receptor and JAK2
    A Sasaki
    Institute of Life Science, Kurume University, Aikawa machi 2432 3, Kurume 839 0861, Japan
    J Biol Chem 275:29338-47. 2000
  8. pmc Placental defects and embryonic lethality in mice lacking suppressor of cytokine signaling 3
    A W Roberts
    The Walter and Eliza Hall Institute of Medical Research and Cooperative Research Centre for Cellular Growth Factors, Post Office, Royal Melbourne Hospital, Victoria 3050, Australia
    Proc Natl Acad Sci U S A 98:9324-9. 2001
  9. doi Suppressors of cytokine signaling modulate JAK/STAT-mediated cell responses during atherosclerosis
    Guadalupe Ortiz-Muñoz
    Renal and Vascular Inflammation Lab, Fundacion Jimenez Diaz, Autonoma University, Madrid, Spain
    Arterioscler Thromb Vasc Biol 29:525-31. 2009
  10. ncbi Overexpression of suppressor of cytokine signaling 3 in adipose tissue causes local but not systemic insulin resistance
    Hang Shi
    Division of Endocrinology, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215, USA
    Diabetes 55:699-707. 2006

Research Grants

  1. 67 KD LAMININ BINDING PROTEIN ON HUMAN T LYMPHOCYTES
    Stephen Canfield; Fiscal Year: 2003
  2. Axima-CFR MALDI TOF Mass Spectrometer
    EDWARD FEENER; Fiscal Year: 2003
  3. MATERNAL IMMUNE TOLERANCE TO THE ALLOGENEIC FETUS
    Adrian Erlebacher; Fiscal Year: 2003
  4. Regulation of angiotensin-induced PAI-1 expression
    EDWARD FEENER; Fiscal Year: 2006

Scientific Experts

Detail Information

Publications130 found, 100 shown here

  1. ncbi The N-terminal truncated isoform of SOCS3 translated from an alternative initiation AUG codon under stress conditions is stable due to the lack of a major ubiquitination site, Lys-6
    Atsuo Sasaki
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    J Biol Chem 278:2432-6. 2003
    The suppressor of cytokine signaling-3 (SOCS3/CIS-33/SSI-3) is an important negative regulator of cytokine signaling...
  2. ncbi Pim-1 kinase inhibits STAT5-dependent transcription via its interactions with SOCS1 and SOCS3
    Katriina J Peltola
    Turku Centre for Biotechnology, University of Turku Abo Akademi University, Turku, Finland
    Blood 103:3744-50. 2004
    ..By contrast, Pim-1 interacts with suppressor of cytokine signaling 1 (SOCS1) and SOCS3 and potentiates their inhibitory effects on STAT5, most likely via phosphorylation-mediated stabilization of the ..
  3. ncbi Deletion of the SOCS3 gene in liver parenchymal cells promotes hepatitis-induced hepatocarcinogenesis
    Hisanobu Ogata
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Graduate School of Medical Science, Kyushu University, Higashiku, Fukuoka, Japan
    Gastroenterology 131:179-93. 2006
    A recent study has suggested that the methylation silencing of the suppressor of cytokine signaling-3 (SOCS3), a negative regulator of interleukin-6-related cytokines, could be involved in hepatocellular carcinoma (HCC)...
  4. ncbi Loss of SOCS3 gene expression converts STAT3 function from anti-apoptotic to pro-apoptotic
    Yang Lu
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    J Biol Chem 281:36683-90. 2006
    ..In this report, we generated SOCS3-deficient murine embryonic fibroblasts (MEFs), in which STAT3 activation is extremely enhanced and prolonged...
  5. ncbi SOCS3 is required to temporally fine-tune photoreceptor cell differentiation
    Yoko Ozawa
    Department of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Dev Biol 303:591-600. 2007
    b>Suppressor of cytokine signaling 3 (SOCS3) is an intracellular, ligand-induced negative feedback modulator of STAT3 activation that acts during inflammation...
  6. ncbi SOCS3 regulates the plasticity of gp130 signaling
    Roland Lang
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Nat Immunol 4:546-50. 2003
    ..b>SOCS3 is upregulated by several signals in macrophages and has been implicated as a regulator of various signaling ..
  7. ncbi CIS3/SOCS-3 suppresses erythropoietin (EPO) signaling by binding the EPO receptor and JAK2
    A Sasaki
    Institute of Life Science, Kurume University, Aikawa machi 2432 3, Kurume 839 0861, Japan
    J Biol Chem 275:29338-47. 2000
    The cytokine-inducible SH2 protein-3 (CIS3/SOCS-3/SSI-3) has been shown to inhibit the JAK/STAT pathway and act as a negative regulator of fetal liver erythropoiesis...
  8. pmc Placental defects and embryonic lethality in mice lacking suppressor of cytokine signaling 3
    A W Roberts
    The Walter and Eliza Hall Institute of Medical Research and Cooperative Research Centre for Cellular Growth Factors, Post Office, Royal Melbourne Hospital, Victoria 3050, Australia
    Proc Natl Acad Sci U S A 98:9324-9. 2001
    Mice lacking suppressor of cytokine signaling 3 (SOCS3) exhibited embryonic lethality with death occurring between days 11 and 13 of gestation...
  9. doi Suppressors of cytokine signaling modulate JAK/STAT-mediated cell responses during atherosclerosis
    Guadalupe Ortiz-Muñoz
    Renal and Vascular Inflammation Lab, Fundacion Jimenez Diaz, Autonoma University, Madrid, Spain
    Arterioscler Thromb Vasc Biol 29:525-31. 2009
    ..We investigated the effects of SOCS modulation on the JAK/STAT-dependent responses in vascular cells, and their implication in atherosclerotic plaque development...
  10. ncbi Overexpression of suppressor of cytokine signaling 3 in adipose tissue causes local but not systemic insulin resistance
    Hang Shi
    Division of Endocrinology, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215, USA
    Diabetes 55:699-707. 2006
    ..Moreover, SOCS3 is required for tumor necrosis factor-alpha full inhibition of insulin-stimulated IRS-1 and -2 phosphorylation, ..
  11. doi CCL11 blocks IL-4 and GM-CSF signaling in hematopoietic cells and hinders dendritic cell differentiation via suppressor of cytokine signaling expression
    Nigel J Stevenson
    Infection and Immunity, Cancer Research and Cell Biology, School of Biomedical Science, Queen s University of Belfast, Belfast, Northern Ireland
    J Leukoc Biol 85:289-97. 2009
    ..In this study, we find that CCL11 induces suppressor of cytokine signaling (SOCS)1 and SOCS3 expression in murine macrophages, human monocytes, and dendritic cells (DCs)...
  12. pmc Oral administration of high molecular weight hyaluronan (900 kDa) controls immune system via Toll-like receptor 4 in the intestinal epithelium
    Akira Asari
    Hyaluronan Research Institute Inc, 4 5 9 Kichijojiminami cho, Musashino shi, Tokyo 180 0003, Japan
    J Biol Chem 285:24751-8. 2010
    ..DNA array analysis of the tissue from the large intestine showed that HA900 treatment up-regulated suppressor of cytokine signaling 3 (SOCS3) expression and down-regulated pleiotrophin expression...
  13. ncbi Opposing roles of gp130-mediated STAT-3 and ERK-1/ 2 signaling in liver progenitor cell migration and proliferation
    George C T Yeoh
    UWA Centre for Medical Research, The Western Australian Institute for Medical Research, Perth, Australia
    Hepatology 45:486-94. 2007
    ..For the first time, we have dissected the gp130-mediated signaling pathways, which influence liver progenitor oval cell proliferation...
  14. ncbi Cloning and characterization of novel CIS family genes
    M Masuhara
    Institute of Life Science, Kurume University, Japan
    Biochem Biophys Res Commun 239:439-46. 1997
    ..Here we cloned three additional CIS family genes (CIS2, CIS3, and CIS4) on the basis of an expression sequence tag (EST) database search...
  15. pmc Suppressor of cytokine signaling 3 limits protection of leukemia inhibitory factor receptor signaling against central demyelination
    Ben Emery
    Department of Neurobiology, Stanford University, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 103:7859-64. 2006
    ..in other cell types, LIFR signaling is under tight negative regulation by the intracellular protein suppressor of cytokine signaling 3 (SOCS3)...
  16. ncbi The dual function of hepatic SOCS3 in insulin resistance in vivo
    Takehiro Torisu
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, University of Kyushu, Maidashi 3 1 1, Fukuoka 812 8582, Japan
    Genes Cells 12:143-54. 2007
    ..The suppressor of cytokine signaling 3 (SOCS3), which is induced by pro-inflammatory cytokines, such as TNFalpha and IL-6, has been ..
  17. ncbi Suppressor of cytokine signaling-3 (SOCS-3), a potential mediator of interleukin-6-dependent insulin resistance in hepatocytes
    Joseph J Senn
    Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, New York 14642, USA
    J Biol Chem 278:13740-6. 2003
    ..These data suggest that induction of SOCS-3 in liver may be an important mechanism of IL-6-mediated insulin resistance...
  18. ncbi Chronic tumor necrosis factor-alpha treatment causes insulin resistance via insulin receptor substrate-1 serine phosphorylation and suppressor of cytokine signaling-3 induction in 3T3-L1 adipocytes
    Ken Ishizuka
    The First Department of Internal Medicine, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Endocrinology 148:2994-3003. 2007
    Serine phosphorylation of insulin receptor substrate (IRS)-1 and the induction of suppressor of cytokine signaling 3 (SOCS3) is recently well documented as the mechanisms for the insulin resistance...
  19. ncbi SOCS3 is essential in the regulation of fetal liver erythropoiesis
    J C Marine
    Howard Hughes Medical Institute, and Department of Biochemistry, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Cell 98:617-27. 1999
    b>SOCS3 (CIS3/JAB2) is an SH2-containing protein that binds to the activation loop of Janus kinases, inhibiting kinase activity, and thereby suppressing cytokine signaling...
  20. ncbi Cutting edge: IL-4 induces suppressor of cytokine signaling-3 expression in B cells by a mechanism dependent on activation of p38 MAPK
    Stephen Canfield
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    J Immunol 174:2494-8. 2005
    ..b>SOCS3 expression increases 9-fold within 5 h of IL-4 treatment...
  21. ncbi Conditional ablation of Stat3 or Socs3 discloses a dual role for reactive astrocytes after spinal cord injury
    Seiji Okada
    Department of Physiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Nat Med 12:829-34. 2006
    ..deletion of the protein signal transducer and activator of transcription 3 (Stat3) or the protein suppressor of cytokine signaling 3 (Socs3) under the control of the Nes promoter-enhancer (Nes-Stat3(-/-), Nes-Socs3(-/-))...
  22. ncbi Involvement of suppressor of cytokine signaling-3 as a mediator of the inhibitory effects of IL-10 on lipopolysaccharide-induced macrophage activation
    Chiara Berlato
    Department of Pathology, Section of General Pathology, University of Verona, Verona, Italy
    J Immunol 168:6404-11. 2002
    Previous studies have shown that IL-10 can induce the expression of the suppressor of cytokine signaling 3 (SOCS-3) mRNA in human monocytes and neutrophils, suggesting that the capacity of IL-10 to inhibit the expression of LPS-inducible ..
  23. ncbi BCL10 mediates lipopolysaccharide/toll-like receptor-4 signaling through interaction with Pellino2
    Yingle Liu
    Key Laboratory of Virology Ministry of Education, Department of Biotechnology, College of Life Sciences, Wuhan University, Hubei, Wuhan 430072, People s Republic of China
    J Biol Chem 279:37436-44. 2004
    ..In addition, we found that BCL10 was targeted by SOCS3 for negative regulation in LPS signaling...
  24. ncbi Molecular mechanism of lipopolysaccharide-induced SOCS-3 gene expression in macrophages and microglia
    Hongwei Qin
    Department of Cell Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Immunol 179:5966-76. 2007
    ....
  25. pmc Autoregulation of pituitary corticotroph SOCS-3 expression: characterization of the murine SOCS-3 promoter
    C J Auernhammer
    Department of Medicine, Cedars Sinai Research Institute, University of California School of Medicine, Los Angeles, CA 90048, USA
    Proc Natl Acad Sci U S A 96:6964-9. 1999
    ..These results demonstrate a mechanism for corticotroph plasticity with rapid "on" and "off" ACTH induction in response to neuro-immuno-endocrine stimuli, such as LIF...
  26. ncbi SOCS3 negatively regulates IL-6 signaling in vivo
    Ben A Croker
    Cancer and Haematology Division, The Walter and Eliza Hall Institute of Medical Research and the Cooperative Research Centre for Cellular Growth Factors, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Nat Immunol 4:540-5. 2003
    ..To examine whether SOCS3 is involved in regulating this signaling, we have used conditional gene targeting to generate mice lacking Socs3 ..
  27. pmc Interleukin-10 anti-inflammatory response to Borrelia burgdorferi, the agent of Lyme disease: a possible role for suppressors of cytokine signaling 1 and 3
    Vida A Dennis
    Division of Bacteriology and Parasitology, Tulane National Primate Research Center, 18703 Three Rivers Rd, Covington, LA 70433, USA
    Infect Immun 74:5780-9. 2006
    ..freeze-thawed, live, or sonicated) or lipidated outer surface protein A (L-OspA) augmented their SOCS1/SOCS3 mRNA and protein expression, with SOCS3 being more abundant...
  28. doi Leukemia inhibitory factor regulates trophoblast giant cell differentiation via Janus kinase 1-signal transducer and activator of transcription 3-suppressor of cytokine signaling 3 pathway
    Yutaka Takahashi
    Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Mol Endocrinol 22:1673-81. 2008
    b>Suppressor of cytokine signaling 3 (SOCS3) inhibits leukemia-inhibitory factor (LIF) signaling and acts as a negative regulator...
  29. ncbi A family of cytokine-inducible inhibitors of signalling
    R Starr
    The Walter and Eliza Hall Institute for Medical Research, Parkville, Victoria, Australia
    Nature 387:917-21. 1997
    ..Transcription of all four SOCS genes is increased rapidly in response to interleukin-6, in vitro and in vivo, suggesting they may act in a classic negative feedback loop to regulate cytokine signal transduction...
  30. pmc Twenty proteins containing a C-terminal SOCS box form five structural classes
    D J Hilton
    The Walter and Eliza Hall Institute for Medical Research and The Cooperative Research Center for Cellular Growth Factors, Parkville, Victoria 3050, Australia
    Proc Natl Acad Sci U S A 95:114-9. 1998
    ..The expression of representative members of each class of proteins differs markedly, as does the regulation of expression by cytokines. The function of the WSB, SSB, and ASB protein families remains to be determined...
  31. pmc Mutational analyses of the SOCS proteins suggest a dual domain requirement but distinct mechanisms for inhibition of LIF and IL-6 signal transduction
    S E Nicholson
    The Walter and Eliza Hall Institute of Medical Research and the Cooperative Research Center for Cellular Growth Factors, Parkville, Victoria 3050, Australia
    EMBO J 18:375-85. 1999
    ..Thus, although inhibition of signaling by SOCS-1 and SOCS-3 requires both the SH2 and N-terminal domains, their mechanisms of action appear to be biochemically different...
  32. ncbi Expression of "suppressor of cytokine signalling" (SOCS) genes in the developing and adult mouse nervous system
    M N Polizzotto
    The Walter and Eliza Hall Institute of Medical Research, Post Office, The Royal Melbourne Hospital, Parkville, Victoria 3050, Australia
    J Comp Neurol 423:348-58. 2000
    ..Its expression pattern indicated that SOCS-2 was expressed exclusively in neurons and that it was switched on developmentally at the time of neuronal differentiation...
  33. ncbi Suppressors of cytokine signaling proteins are differentially expressed in Th1 and Th2 cells: implications for Th cell lineage commitment and maintenance
    Charles E Egwuagu
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 168:3181-7. 2002
    ..We show here that CD4(+) naive T cells constitutively express low levels of SOCS1, SOCS2, and SOCS3 mRNAs...
  34. ncbi SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2
    Liangyou Rui
    Howard Hughes Medical Institute, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 277:42394-8. 2002
    ..Inflammation induces the expression of SOCS proteins. We show that SOCS1 or SOCS3 targeted IRS1 and IRS2, two critical signaling molecules for insulin action, for ubiquitin-mediated degradation...
  35. pmc Expression of the suppressor of cytokine signaling-5 (SOCS5) negatively regulates IL-4-dependent STAT6 activation and Th2 differentiation
    Yoh Ichi Seki
    Research Institute for Biological Sciences, Tokyo University of Science, 2669 Yamazaki, Noda City, Chiba 278 0022, Japan
    Proc Natl Acad Sci U S A 99:13003-8. 2002
    ..Therefore, the induced SOCS5 protein in Th1 differentiation environment may play an important role by regulating Th1 and Th2 balance...
  36. ncbi SHP2 and SOCS3 contribute to Tyr-759-dependent attenuation of interleukin-6 signaling through gp130
    Ute Lehmann
    Department of Biochemistry, Rheinisch Westfälische Technische Hochschule Aachen, Pauwelsstrasse 30, Aachen D 52074, Germany
    J Biol Chem 278:661-71. 2003
    ..We recently observed that the suppressor of cytokine-signaling SOCS3 also acts through the tyrosine motif 759 of gp130...
  37. pmc A role of suppressor of cytokine signaling 3 (SOCS3/CIS3/SSI3) in CD28-mediated interleukin 2 production
    Akira Matsumoto
    Research Institute for Biological Sciences, Tokyo University of Science, Chiba 278 0022, Japan
    J Exp Med 197:425-36. 2003
    ..However, this study shows that T cells from transgenic mice expressing SOCS3 exhibit a significant reduction in interleukin (IL)-2 production induced by T cell receptor cross-linking when T ..
  38. ncbi IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages
    Hideo Yasukawa
    Institute of Molecular Medicine and Department of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093 0641, USA
    Nat Immunol 4:551-6. 2003
    ..Here we show that suppressor of cytokine signaling 3 (SOCS3) is a key regulator of the divergent action of these two cytokines...
  39. ncbi Suppressor of cytokine signaling 3 regulates proliferation and activation of T-helper cells
    Cheng Rong Yu
    Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 278:29752-9. 2003
    ..We show that SOCS1, SOCS2, SOCS3, CIS (cytokine-induced SH2 protein) genes are constitutively expressed in naïve T-helper cells, with SOCS3 being ..
  40. ncbi SOCS-3 regulates onset and maintenance of T(H)2-mediated allergic responses
    Yoh Ichi Seki
    Research Institute for Biological Sciences, Tokyo University of Science, 2669 Yamazaki, Noda City, Chiba 278 0022, Japan
    Nat Med 9:1047-54. 2003
    ..In contrast, dominant-negative mutant SOCS-3 transgenic mice, as well as mice with a heterozygous deletion of Socs3, had decreased T(H)2 development...
  41. ncbi SOCS3 is a physiological negative regulator for granulopoiesis and granulocyte colony-stimulating factor receptor signaling
    Akiko Kimura
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    J Biol Chem 279:6905-10. 2004
    The suppressor of cytokine signaling-3 (SOCS3/CIS3) has been shown to be an important negative regulator of cytokines, especially cytokines that activate STAT3...
  42. ncbi SOCS3 is a critical physiological negative regulator of G-CSF signaling and emergency granulopoiesis
    Ben A Croker
    Cancer and Haematology Division, The Walter and Eliza Hall Institute of Medical Research and the Cooperative Research Centre for Cellular Growth Factors, Parkville, Victoria 3050, Australia
    Immunity 20:153-65. 2004
    To determine the importance of suppressor of cytokine signaling-3 (SOCS3) in the regulation of hematopoietic growth factor signaling generally, and of G-CSF-induced cellular responses specifically, we created mice in which the Socs3 gene ..
  43. ncbi Suppressor of cytokine signaling 3 is a physiological regulator of adipocyte insulin signaling
    Hang Shi
    Division of Endocrinology, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
    J Biol Chem 279:34733-40. 2004
    ..We observed that several cytokines and hormones that induce insulin resistance also stimulate SOCS3 expression in 3T3-L1 adipocytes and that SOCS3 mRNA is increased in adipose tissue of obese/diabetic mice...
  44. ncbi Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity
    Hiroyuki Mori
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Nat Med 10:739-43. 2004
    ..In vitro analysis suggested that the suppressor of cytokine signaling-3 (Socs3) is a negative-feedback regulator of leptin signaling involved in leptin resistance...
  45. ncbi Enhanced leptin sensitivity and attenuation of diet-induced obesity in mice with haploinsufficiency of Socs3
    Jane K Howard
    Department of Medicine, Division of Endocrinology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Nat Med 10:734-8. 2004
    ..We have previously identified suppressor of cytokine signaling-3 (Socs3) as a leptin-induced negative regulator of leptin receptor signaling and potential mediator of leptin resistance...
  46. pmc Central role of suppressors of cytokine signaling proteins in hepatic steatosis, insulin resistance, and the metabolic syndrome in the mouse
    Kohjiro Ueki
    Research Division, Joslin Diabetes Center and Department of Medicine, Harvard Medical School, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 101:10422-7. 2004
    ..Thus, SOCS proteins play an important role in pathogenesis of the metabolic syndrome by concordantly modulating insulin signaling and cytokine signaling...
  47. ncbi Suppressor of cytokine signaling (SOCS) proteins indirectly regulate toll-like receptor signaling in innate immune cells
    Andrea Baetz
    Institute of Medical Microbiology and Hygiene, Philipps University Marburg, 35037 Marburg, Germany
    J Biol Chem 279:54708-15. 2004
    ..Thus, our data suggest that SOCS proteins induced by TLR stimulation limit the extent of TLR signaling by inhibiting type I IFN signaling but not the main NF kappa B pathway...
  48. pmc Activation of SOCS-3 by resistin
    Claire M Steppan
    Pfizer Inc, PRGD, MS220 3145, Eastern Point Rd, Groton, CT 06340, USA
    Mol Cell Biol 25:1569-75. 2005
    ..Remarkably, resistin treatment markedly induces the gene expression of suppressor of cytokine signaling 3 (SOCS-3), a known inhibitor of insulin signaling...
  49. ncbi Mechanisms of SOCS3 phosphorylation upon interleukin-6 stimulation. Contributions of Src- and receptor-tyrosine kinases
    Ulrike Sommer
    Institut fur Biochemie, Rheinisch Westfälische Technische Hochschule Aachen, Pauwelsstrasse 30, D 52074 Aachen, Germany
    J Biol Chem 280:31478-88. 2005
    The suppressors of cytokine signaling (SOCS) are negative feedback inhibitors of cytokine signal transduction. SOCS3 is a key negative regulator of interleuking-6 (IL-6) signal transduction...
  50. ncbi Intracellular protein therapy with SOCS3 inhibits inflammation and apoptosis
    Daewoong Jo
    Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Vanderbilt University Medical Center, 1161 21st Avenue South, A 5321 MCN, Nashville, Tennessee 37232, USA
    Nat Med 11:892-8. 2005
    ..B (SEB) and lipopolysaccharide (LPS), or the lectin concanavalin A (ConA), suggesting that physiologic levels of SOCS3 are insufficient to stem proinflammatory signaling under pathogenic circumstances...
  51. ncbi Interleukin-6 plays a crucial role in the hepatic expression of SOCS3 during acute inflammatory processes in vivo
    Xiang Ping Yang
    Department of Biochemistry, Medical School, RWTH Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    J Hepatol 43:704-10. 2005
    ..However, several signaling pathways converge on SOCS3: SOCS3 can be induced by other mediators in vitro, and it does not exclusively inhibit IL-6 signaling...
  52. ncbi Regulation of pancreatic beta-cell mass and proliferation by SOCS-3
    K Lindberg
    Department of Signal Transduction, Novo Nordisk A S, Bagsvaerd, Denmark
    J Mol Endocrinol 35:231-43. 2005
    ..Together these data suggest that SOCS-3 modulates cytokine signaling in pancreatic beta-cells and therefore potentially could be a candidate target for development of new treatment strategies for diabetes...
  53. ncbi IL-6 modulates hepatocyte proliferation via induction of HGF/p21cip1: regulation by SOCS3
    Rui Sun
    Section on Liver Biology, Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
    Biochem Biophys Res Commun 338:1943-9. 2005
    The precise role of IL-6 in liver regeneration and hepatocyte proliferation is controversial and the role of SOCS3 in liver regeneration remains unknown...
  54. ncbi Secondary structure assignment of mouse SOCS3 by NMR defines the domain boundaries and identifies an unstructured insertion in the SH2 domain
    Jeffrey J Babon
    Walter and Eliza Hall Institute, Parkville, Victoria, Australia
    FEBS J 272:6120-30. 2005
    b>SOCS3 is a negative regulator of cytokine signalling that inhibits Janus kinase-signal transduction and activator of transcription (JAK-STAT) mediated signal tranduction by binding to phosphorylated tyrosine residues on intracellular ..
  55. ncbi Divergent mechanisms utilized by SOCS3 to mediate interleukin-10 inhibition of tumor necrosis factor alpha and nitric oxide production by macrophages
    Pooran Qasimi
    Department of Surgery, University of British Columbia, Immunity and Infection Research Centre and Prostate Cancer Reseach Centre, Vancouver Coastal Health Research Institute, Vancouver, British Columbia V6H 3Z6 Canada
    J Biol Chem 281:6316-24. 2006
    ..The expression of SOCS3 (suppressor of cytokine signaling-3) has been shown to be induced by IL-10 in a STAT3-dependent manner...
  56. ncbi The comparative roles of suppressor of cytokine signaling-1 and -3 in the inhibition and desensitization of cytokine signaling
    Samuel Wormald
    Division of Cancer and Haematology, The Walter and Eliza Hall Institute of Medicial Research, Parkville, Victoria, Australia
    J Biol Chem 281:11135-43. 2006
    ..STAT3 tyrosine phosphorylation was bi-phasic in response to continuous IL-6 signaling. In macrophages lacking Socs3, however, continuous IL-6 signaling induced uniformly high levels of STAT3 tyrosine phosphorylation, and early IL-..
  57. ncbi Loss of SOCS3 in the liver promotes fibrosis by enhancing STAT3-mediated TGF-beta1 production
    H Ogata
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Fukuoka, Japan
    Oncogene 25:2520-30. 2006
    Recently, DNA methylation and reduced expression of the suppressor of the cytokine signaling-3 (SOCS3) gene in human hepatocellular carcinoma (HCC) patients have been reported...
  58. pmc Loss of SOCS3 in T helper cells resulted in reduced immune responses and hyperproduction of interleukin 10 and transforming growth factor-beta 1
    Ichiko Kinjyo
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, Higashi ku, Fukuoka 812 8582, Japan
    J Exp Med 203:1021-31. 2006
    ..Transgenic mouse studies indicate that high levels of SOCS3 in T cells result in type 2 T helper cell (Th2) skewing and lead to hypersensitivity to allergic diseases...
  59. pmc Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells
    Zhi Chen
    Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 103:8137-42. 2006
    ..We show that deficiency of Socs3 in T cells had minimal effects on differentiation of T cells to the T helper (Th) 1 or Th2 subsets; accordingly, ..
  60. pmc SOCS-3 negatively regulates innate and adaptive immune mechanisms in acute IL-1-dependent inflammatory arthritis
    Peter K K Wong
    Reid Rheumatology Laboratory, Division of Autoimmunity and Transplantation, Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    J Clin Invest 116:1571-81. 2006
    ..The generation of Socs3(-/Delta vav) mice, which lack SOCS-3 in the hematopoietic and endothelial cell compartment, allowed us to explore ..
  61. ncbi Adenoviral-mediated overexpression of SOCS3 enhances IgG immune complex-induced acute lung injury
    Hongwei Gao
    Department of Pathology, University of Michigan Medical School, 1301 Catherine Road, Ann Arbor, MI 48109, USA
    J Immunol 177:612-20. 2006
    ..Recently, suppressor of cytokine signaling 3 (SOCS3) has been shown to be a key negative regulator of IL-6/gp130/Jak/STAT3 signal transduction...
  62. ncbi Enhanced leptin sensitivity and improved glucose homeostasis in mice lacking suppressor of cytokine signaling-3 in POMC-expressing cells
    Paul Kievit
    Division of Endocrinology, Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, Massachusetts 02215, USA
    Cell Metab 4:123-32. 2006
    ..These studies demonstrate that Socs-3 within POMC neurons regulates leptin sensitivity and glucose homeostasis, and plays a key role in linking high-fat diet to disordered metabolism...
  63. ncbi Structural basis for phosphotyrosine recognition by suppressor of cytokine signaling-3
    Elisa Bergamin
    Structural Biology Program, Skirball Institute of Biomolecular Medicine and Department of Pharmacology, New York University School of Medicine, New York, New York 10016, USA
    Structure 14:1285-92. 2006
    ..The N-terminal region in SOCS1 and SOCS3 includes the so-called kinase inhibitory region that has been shown to inhibit the catalytic activity of JAK2...
  64. ncbi Adipokine gene expression in a novel hypothalamic neuronal cell line: resistin-dependent regulation of fasting-induced adipose factor and SOCS-3
    Russell Brown
    Department of Obstetrics, Faculty of Medicine, Dalhousie University, Halifax, N S, Canada
    Neuroendocrinology 85:232-41. 2007
    ..However, it remains to be determined whether these in vitro results can be translated to the control of adipokine expression in brain and adipose tissue...
  65. ncbi Regulation of suppressor of cytokine signaling 3 (SOC3) by growth hormone in pro-B cells
    Johanna L Barclay
    School of Biomedical Sciences, University of Queensland, Queensland 4072, Australia
    Mol Endocrinol 21:2503-15. 2007
    b>Suppressor of cytokine signaling 3 (SOCS3) is expressed by lymphoid cells and can modulate the sensitivity of these cells to cytokine stimulation through inhibition of Janus kinase (JAK)/signal transducers and activators of transcription (..
  66. ncbi Selective expansion of foxp3-positive regulatory T cells and immunosuppression by suppressors of cytokine signaling 3-deficient dendritic cells
    Yumiko Matsumura
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
    J Immunol 179:2170-9. 2007
    ..b>SOCS3(-/-) DCs expressed lower levels of class II MHC, CD40, CD86, and IL-12 than wild-type (WT)-DCs both in vitro and ..
  67. ncbi SOCS3 suppresses AP-1 transcriptional activity in neuroblastoma cells through inhibition of c-Jun N-terminal kinase
    Tizong Miao
    Centre for Neuroscience, Queen Mary s School of Medicine, University of London, E1 2AT, London, UK
    Mol Cell Neurosci 37:367-75. 2008
    ..Overexpression of SOCS3 (suppressor of cytokine signaling) inhibited and mutant SOCS3 (with an inactivating point mutation in amino acid ..
  68. doi SOCS3 negatively regulates the gp130-STAT3 pathway in mouse skin wound healing
    Bing Mei Zhu
    Laboratory of Genetics and Physiology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Invest Dermatol 128:1821-9. 2008
    ..b>Socs3 alleles flanked by loxP sites were deleted in mice with either an MMTV-Cre or K5-Cre transgene...
  69. doi NOTCH1 up-regulation and signaling involved in Mycobacterium bovis BCG-induced SOCS3 expression in macrophages
    Yeddula Narayana
    Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore 560012, India
    J Biol Chem 283:12501-11. 2008
    ..is known about the early receptor proximal signaling mechanisms underlying mycobacteria-mediated induction of SOCS3. We demonstrate here for the first time that M...
  70. pmc Socs3 maintains the specificity of biological responses to cytokine signals during granulocyte and macrophage differentiation
    Ben A Croker
    Cancer and Haematology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    Exp Hematol 36:786-98. 2008
    ..and are both negatively regulated by the inducible intracellular protein suppressor of cytokine signaling-3 (Socs3)...
  71. pmc The SOCS box domain of SOCS3: structure and interaction with the elonginBC-cullin5 ubiquitin ligase
    Jeffrey J Babon
    Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia
    J Mol Biol 381:928-40. 2008
    Suppressor of cytokine signalling 3 (SOCS3) is responsible for regulating the cellular response to a variety of cytokines, including interleukin 6 and leukaemia inhibitory factor...
  72. pmc Selective inactivation of Socs3 in SF1 neurons improves glucose homeostasis without affecting body weight
    Ren Zhang
    Division of Endocrinology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Endocrinology 149:5654-61. 2008
    b>Suppressor of cytokine signaling 3 (Socs3) has been identified as a mediator of central leptin resistance, but the identity of specific neurons in which Socs3 acts to suppress leptin signaling remains elusive...
  73. pmc Deletion of the SOCS box of suppressor of cytokine signaling 3 (SOCS3) in embryonic stem cells reveals SOCS box-dependent regulation of JAK but not STAT phosphorylation
    Kristy Boyle
    The Walter and Eliza Hall Institute, 1G Royal Parade, Parkville, Victoria 3050, Australia
    Cell Signal 21:394-404. 2009
    The mechanism by which Suppressor of Cytokine Signaling-3 (SOCS3) negatively regulates cytokine signaling has been widely investigated using over-expression studies in cell lines and is thought to involve interactions with both the gp130 ..
  74. doi Inhibition of monocyte-derived inflammatory cytokines by IL-25 occurs via p38 Map kinase-dependent induction of Socs-3
    Roberta Caruso
    Department of Internal Medicine and Centre of Excellence for Genomic Risk Assessment in Multifactorial and Complex Diseases, University Tor Vergata of Rome, Rome, Italy
    Blood 113:3512-9. 2009
    ..These data indicate that IL-25 is a negative regulator of monocyte proinflammatory cytokine responses, which may have therapeutic implications...
  75. doi Lipopolysaccharide (LPS) stimulates adipokine and socs3 gene expression in mouse brain and pituitary gland in vivo, and in N-1 hypothalamic neurons in vitro
    Russell Brown
    Department of Obstetrics and Gynaecology, Faculty of Medicine, Dalhousie University, c o IWK Health Centre, Nova Scotia, Canada
    J Neuroimmunol 209:96-103. 2009
    ....
  76. pmc The SOCS box encodes a hierarchy of affinities for Cullin5: implications for ubiquitin ligase formation and cytokine signalling suppression
    Jeffrey J Babon
    Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria, Australia
    J Mol Biol 387:162-74. 2009
    ....
  77. pmc SOCS3 deletion promotes optic nerve regeneration in vivo
    Patrice D Smith
    F M Kirby Neurobiology Center, Children s Hospital, and Department of Neurology, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
    Neuron 64:617-23. 2009
    ..In analyzing axon regeneration in different mutant mouse lines, we discovered that deletion of suppressor of cytokine signaling 3 (SOCS3) in adult retinal ganglion cells (RGCs) promotes robust regeneration of injured optic nerve ..
  78. pmc IL-17 enhancement of the IL-6 signaling cascade in astrocytes
    Xiangyu Ma
    Department of Cell Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Immunol 184:4898-906. 2010
    ..b>SOCS3 small interfering RNA knockdown and SOCS3 deletion in astrocytes augmented the synergistic effect of IL-6 and IL-..
  79. pmc SOCS3 regulates graft-versus-host disease
    Geoffrey R Hill
    The Queensland Institute of Medical Research, 300 Herston Rd, Brisbane, Queensland 4006, Australia
    Blood 116:287-96. 2010
    Suppressor of cytokine signaling-3 (SOCS3) is the main intracellular regulator of signaling by granulocyte colony-stimulating factor, an immune-modulatory cytokine used to mobilize stem cells for transplantation...
  80. pmc Suppressor of cytokine signaling 3 inhibits antiviral IFN-beta signaling to enhance HIV-1 replication in macrophages
    Lisa Nowoslawski Akhtar
    Department of Cell Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Immunol 185:2393-404. 2010
    ..We found that SOCS3 is elevated in an in vivo SIV/macaque model of HAD and that the pattern of expression correlates with recurrence ..
  81. doi Liver-specific suppressor of cytokine signaling-3 deletion in mice enhances hepatic insulin sensitivity and lipogenesis resulting in fatty liver and obesity
    Nirupa Sachithanandan
    St Vincent s Institute of Medical Research and Department of Medicine, University of Melbourne, Fitzroy, Victoria, Australia
    Hepatology 52:1632-42. 2010
    ..The suppressor of cytokine signaling-3 (SOCS3) protein is increased in inflammation and is thought to contribute to the pathogenesis of insulin resistance by ..
  82. doi Transcriptional upregulation of SOCS 1 and suppressors of cytokine signaling 3 mRNA in the absence of suppressors of cytokine signaling 2 mRNA after infection with West Nile virus or tick-borne encephalitis virus
    Karen L Mansfield
    Rabies and Wildlife Zoonoses Group, Veterinary Laboratories Agency, New Haw, Addlestone, United Kingdom
    Vector Borne Zoonotic Dis 10:649-53. 2010
    ....
  83. pmc Neuronal suppressor of cytokine signaling-3 deficiency enhances hypothalamic leptin-dependent phosphatidylinositol 3-kinase signaling
    Anantha S Metlakunta
    Dept of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Magee Womens Research Institute, 204 Craft Avenue, Pittsburgh, PA 15213, USA
    Am J Physiol Regul Integr Comp Physiol 300:R1185-93. 2011
    Suppressor of cytokine signaling-3 (SOCS3) is thought to be involved in the development of central leptin resistance and obesity by inhibiting STAT3 pathway...
  84. pmc A critical role for SOCS3 in innate resistance to Toxoplasma gondii
    Ryan J Whitmarsh
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, USA
    Cell Host Microbe 10:224-36. 2011
    ..We show that suppressor of cytokine signaling molecule 3 (SOCS3), a target of STAT3 that limits signaling by the pleiotropic cytokine IL-6, is upregulated in response to ..
  85. pmc Signal transducer and activator of transcription-3/suppressor of cytokine signaling-3 (STAT3/SOCS3) axis in myeloid cells regulates neuroinflammation
    Hongwei Qin
    Department of Cell Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Proc Natl Acad Sci U S A 109:5004-9. 2012
    Suppressor of cytokine signaling (SOCS) proteins are feedback inhibitors of the JAK/STAT pathway. SOCS3 has a crucial role in inhibiting STAT3 activation, cytokine signaling, and inflammatory gene expression in macrophages/microglia...
  86. doi Inactivation of Socs3 in the hypothalamus enhances the hindbrain response to endogenous satiety signals via oxytocin signaling
    Valery Matarazzo
    Aix Marseille Universite, CNRS, Centre de Recherche en Neurobiologie et Neurophysiologie de Marseille UMR 7286, 13344 Marseille Cedex 15, France
    J Neurosci 32:17097-107. 2012
    ..One potential mechanism for such leptin resistance is an increased hypothalamic expression of Suppressor of cytokine signaling 3 (Socs3), a feedback inhibitor of the Jak-Stat pathway that prevents Stat3 activation...
  87. pmc SOCS3 binds specific receptor-JAK complexes to control cytokine signaling by direct kinase inhibition
    Nadia J Kershaw
    Department of Structural Biology, Walter and Eliza Hall Institute, Parkville, Australia
    Nat Struct Mol Biol 20:469-76. 2013
    The inhibitory protein SOCS3 plays a key part in the immune and hematopoietic systems by regulating signaling induced by specific cytokines...
  88. doi Japanese encephalitis virus infection modulates the expression of suppressors of cytokine signaling (SOCS) in macrophages: implications for the hosts' innate immune response
    Kiran Kundu
    National Brain Research Centre, Manesar 122051, India
    Cell Immunol 285:100-10. 2013
    ..On knocking down SOCS1 and SOCS3 we found a significant decrease in viral gene expression at an early time point, indicating the dysregulation of ..
  89. pmc SOCS3: an essential regulator of LIF receptor signaling in trophoblast giant cell differentiation
    Yutaka Takahashi
    Howard Hughes Medical Institute, Department of Biochemistry, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    EMBO J 22:372-84. 2003
    b>Suppressor of cytokine signaling 3 (SOCS3) binds cytokine receptors and thereby suppresses cytokine signaling...
  90. pmc Expression and functional significance of SOCS-1 and SOCS-3 in astrocytes
    Hongwei Qin
    Department of Cell Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Immunol 181:3167-76. 2008
    ..These results indicate that IFN-beta induces SOCS-1 and SOCS-3 in primary astrocytes to attenuate its own chemokine-related inflammation in the CNS...
  91. pmc Suppressor of cytokine signaling 1 (SOCS-1) and SOCS-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanisms
    Kohjiro Ueki
    Research Division, Joslin Diabetes Center, and Departmentof Medicine, Harvard Medical School, Boston, MA 02215, USA
    Mol Cell Biol 24:5434-46. 2004
    ..These data indicate that SOCS-1 and SOCS-3 act as negative regulators in insulin signaling and serve as one of the missing links between insulin resistance and cytokine signaling...
  92. pmc Protective role of STAT3 in NMDA and glutamate-induced neuronal death: negative regulatory effect of SOCS3
    Keun W Park
    Department of Cell, Developmental, and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL, USA
    PLoS ONE 7:e50874. 2012
    ..Signal Transducer and Activator of Transcription-3 (STAT3), and the role of Suppressor Of Cytokine Signaling-3 (SOCS3) in regulating excitotoxic neuronal death in vitro...
  93. pmc E2a-Pbx1 induces aberrant expression of tissue-specific and developmentally regulated genes when expressed in NIH 3T3 fibroblasts
    X Fu
    Department of Pathology, University of California, San Diego, School of Medicine, La Jolla 92093, USA
    Mol Cell Biol 17:1503-12. 1997
    ....
  94. ncbi Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3
    S Minamoto
    Department of Medicine III, Osaka University Medical School, Suita, Japan
    Biochem Biophys Res Commun 237:79-83. 1997
    ..We also demonstrated the structure of human SSI-1...
  95. pmc The role of the inhibitors of interleukin-6 signal transduction SHP2 and SOCS3 for desensitization of interleukin-6 signalling
    Patrick Fischer
    Department of Biochemistry, Faculty of Medicine, RWTH Aachen, Pauwelsstrasse 30, D 52074 Aachen, Germany
    Biochem J 378:449-60. 2004
    ..The Src homology domain 2 (SH2)-containing protein tyrosine phosphatase SHP2 and the feedback inhibitor SOCS3 (suppressor of cytokine signalling) are potent inhibitors of IL-6 signal transduction...
  96. ncbi G-CSF receptor truncations found in SCN/AML relieve SOCS3-controlled inhibition of STAT5 but leave suppression of STAT3 intact
    Gert Jan M van de Geijn
    Institute of Hematology, Erasmus Medical Center, Rotterdam, The Netherlands
    Blood 104:667-74. 2004
    ..Expression of SOCS3 transcripts in bone marrow cells from G-CSF-treated gcsfr-d715 mice was approximately 60% lower than in wild-type (..
  97. ncbi The myeloproliferative disorder-associated JAK2 V617F mutant escapes negative regulation by suppressor of cytokine signaling 3
    Michelle B Hookham
    Infection and Immunity Group, Centre for Cancer Research and Cell Biology, Queen s University, 97 Lisburn Road, Belfast, Northern Ireland, UK
    Blood 109:4924-9. 2007
    ..b>Suppressor of cytokine signaling 3 (SOCS3) is known to be a strong negative regulator of erythropoietin (EPO) signaling through ..
  98. ncbi Essential autocrine regulation by IL-21 in the generation of inflammatory T cells
    Roza Nurieva
    Department of Immunology, M D Anderson Cancer Center, Houston, Texas 77030, USA
    Nature 448:480-3. 2007
    ..IL-21 is therefore an autocrine cytokine that is sufficient and necessary for T(H)17 differentiation, and serves as a target for treating inflammatory diseases...
  99. ncbi Cutting edge: A transcriptional repressor and corepressor induced by the STAT3-regulated anti-inflammatory signaling pathway
    Karim C El Kasmi
    Department of Infectious Diseases, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    J Immunol 179:7215-9. 2007
    ..Collectively our data suggest that ETV3 and SBNO2 are components of the pathways that contribute to the downstream anti-inflammatory effects of IL-10...
  100. ncbi TAM receptors are pleiotropic inhibitors of the innate immune response
    Carla V Rothlin
    Molecular Neurobiology Laboratory, The Salk Institute, La Jolla, CA 92037, USA
    Cell 131:1124-36. 2007
    ..the TAM system, which in turn usurps the IFNAR-STAT1 cassette to induce the cytokine and TLR suppressors SOCS1 and SOCS3. These results illuminate a self-regulating cycle of inflammation, in which the obligatory, cytokine-dependent ..
  101. doi Molecular dissection of gp130-dependent pathways in hepatocytes during liver regeneration
    Uta Dierssen
    Internal Medicine III, University Hospital, Rheinisch Westfälische Technische Hochschule Aachen, Pauwelsstrasse 30, Aachen, Germany
    J Biol Chem 283:9886-95. 2008
    ..was blocked in gp130-DeltaSTAT animals, whereas gp130-DeltaRas mice showed an enhanced APG response and stronger SOCS3 regulation correlating with delayed hepatocyte proliferation...

Research Grants4

  1. 67 KD LAMININ BINDING PROTEIN ON HUMAN T LYMPHOCYTES
    Stephen Canfield; Fiscal Year: 2003
    ..of p67 LBP and the integrin alpha6 to lymphocyte laminin-specific adherence? and (4) What are the contributions of p67 LBP and alpha6 to laminin-mediated lamellipod formation, locomotion, and transendothelial migration? ..
  2. Axima-CFR MALDI TOF Mass Spectrometer
    EDWARD FEENER; Fiscal Year: 2003
    ....
  3. MATERNAL IMMUNE TOLERANCE TO THE ALLOGENEIC FETUS
    Adrian Erlebacher; Fiscal Year: 2003
    ..Genes will be isolated by cDNA representational difference analysis and DNA microchip array analysis. and will be functionally evaluated by their ability to modulate tumor immunogenicity in vivo. ..
  4. Regulation of angiotensin-induced PAI-1 expression
    EDWARD FEENER; Fiscal Year: 2006
    ..51B6.g7g7 mice). The long-term objective is to identify novel targets and approaches to control the blood pressure independent effects of Ang II on PAI-1 expression. ..