Snai3

Summary

Gene Symbol: Snai3
Description: snail family zinc finger 3
Alias: AI643946, Smuc, Zfp293, zinc finger protein SNAI3, protein snail homolog 3, snail homolog 3, snail-related gene from muscle cells, snail-related protein 2, zinc finger protein 293
Species: mouse

Top Publications

  1. pmc A novel snail-related transcription factor Smuc regulates basic helix-loop-helix transcription factor activities via specific E-box motifs
    H Kataoka
    Department of Geriatric Medicine, Graduate School of Medicine, Kyoto University, 54 Kawahara cho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Nucleic Acids Res 28:626-33. 2000
  2. ncbi The snail superfamily of zinc-finger transcription factors
    M Angela Nieto
    Instituto Cajal, Doctor Arce, 37, 28002 Madrid, Spain
    Nat Rev Mol Cell Biol 3:155-66. 2002
  3. ncbi Snail3 orthologues in vertebrates: divergent members of the Snail zinc-finger gene family
    Miguel Manzanares
    Instituto de Investigaciones Biomedicas, CSIC UAM, Arturo Duperier 4, 28029 Madrid, Spain
    Dev Genes Evol 214:47-53. 2004
  4. ncbi Expression of the novel Snai-related zinc-finger transcription factor gene Smuc during mouse development
    Xin Zhuge
    Department of Clinical Innovative Medicine, Translational Research Center, Kyoto University Hospital, Shogoin, Kyoto, Japan
    Int J Mol Med 15:945-8. 2005
  5. pmc Overexpression of Snai3 suppresses lymphoid- and enhances myeloid-cell differentiation
    Timothy Dahlem
    Division of Cell Biology and Immunology, Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT 84112, USA
    Eur J Immunol 42:1038-43. 2012
  6. pmc Deletion of Snai2 and Snai3 results in impaired physical development compounded by lymphocyte deficiency
    Peter D Pioli
    The Division of Cell Biology and Immunology, Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah, United States of America
    PLoS ONE 8:e69216. 2013
  7. pmc Fatal autoimmunity results from the conditional deletion of Snai2 and Snai3
    Peter D Pioli
    Division of Cell Biology and Immunology, Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT 84132, United States Electronic address
    Cell Immunol 295:1-18. 2015
  8. doi Directed Dedifferentiation Using Partial Reprogramming Induces Invasive Phenotype in Melanoma Cells
    Nathalie Knappe
    Skin Cancer Unit, German Cancer Research Center DKFZ, Heidelberg, Germany
    Stem Cells 34:832-46. 2016
  9. pmc Snai2 and Snai3 transcriptionally regulate cellular fitness and functionality of T cell lineages through distinct gene programs
    Peter D Pioli
    Division of Cell Biology and Immunology, Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT 84132, United States Electronic address
    Immunobiology 221:618-33. 2016
  10. pmc The snail family gene snai3 is not essential for embryogenesis in mice
    Cara K Bradley
    Center for Molecular Medicine, Maine Medical Center Research Institute, Scarborough, Maine, United States of America
    PLoS ONE 8:e65344. 2013

Scientific Experts

  • Peter D Pioli
  • M A Nieto
  • Nathalie Knappe
  • Cara K Bradley
  • Timothy Dahlem
  • Mathieu Gouzi
  • Seung Oe Lim
  • John H Weis
  • Janis J Weis
  • C Franci
  • J Scott Hale
  • Xin Zhuge
  • Miguel Manzanares
  • Daniel Novak
  • Mathias Bernhardt
  • Viktor Umansky
  • Kasia Weina
  • Maike Reith
  • Jochen Utikal
  • Christoffer Gebhardt
  • Michael Hölzel
  • Thomas Tüting
  • Lionel Larribere
  • Thomas Gridley
  • Ying Chen
  • Jeong Kyo Yoon
  • Carmen J Booth
  • Xianghua Han
  • Christine R Norton
  • Luke T Krebs
  • Scott Cho
  • Gerald J Spangrude
  • Kerstin Johansson
  • Anne Grapin-Botton
  • Yung Hae Kim
  • Keiichi Katsumoto
  • Guhung Jung
  • Hongtae Kim
  • H Kataoka
  • F Alameda
  • M Escriva
  • M Takkunen
  • S Gomez
  • I Virtanen
  • B Montserrat-Sentis
  • M Garrido
  • Irina Debnath
  • Rebecca L Margraf
  • T Baro
  • A Garcia de Herreros
  • F Bonilla
  • R Rodriguez
  • N Dave
  • Timothy J Dahlem
  • Hideto Sano
  • Makoto Tanaka
  • Takahiro Kawamoto
  • Yang Xu
  • Masayuki Yokode
  • Ryoko Yamauchi
  • Hiroshi Kataoka
  • Toshinori Murayama
  • Yukihiko Ueda
  • Toru Kita
  • Kiyonori Togi
  • Shin ichi Nishikawa
  • Maria Jose Blanco
  • H Sano
  • M Yokode
  • T Kita
  • T Murayama
  • S Mori
  • S Nishikawa
  • Y Yokota
  • H Ozaki

Detail Information

Publications14

  1. pmc A novel snail-related transcription factor Smuc regulates basic helix-loop-helix transcription factor activities via specific E-box motifs
    H Kataoka
    Department of Geriatric Medicine, Graduate School of Medicine, Kyoto University, 54 Kawahara cho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Nucleic Acids Res 28:626-33. 2000
    ..We identified a novel Snail -related gene from murine skeletalmusclecells designated Smuc. Northern blot analysis showed that Smuc was highly expressed in skeletal muscle and thymus...
  2. ncbi The snail superfamily of zinc-finger transcription factors
    M Angela Nieto
    Instituto Cajal, Doctor Arce, 37, 28002 Madrid, Spain
    Nat Rev Mol Cell Biol 3:155-66. 2002
    ..Different family members have also been implicated in the signalling cascade that confers left right identity, as well as in the formation of appendages, neural differentiation, cell division and cell survival...
  3. ncbi Snail3 orthologues in vertebrates: divergent members of the Snail zinc-finger gene family
    Miguel Manzanares
    Instituto de Investigaciones Biomedicas, CSIC UAM, Arturo Duperier 4, 28029 Madrid, Spain
    Dev Genes Evol 214:47-53. 2004
    ..We further show that all three Snail genes lie in regions of extensive paralogy, revealing their common origin through segmental or chromosomal duplication...
  4. ncbi Expression of the novel Snai-related zinc-finger transcription factor gene Smuc during mouse development
    Xin Zhuge
    Department of Clinical Innovative Medicine, Translational Research Center, Kyoto University Hospital, Shogoin, Kyoto, Japan
    Int J Mol Med 15:945-8. 2005
    ..gene known as snail-related transcription factor of muscle cells (Smuc) or, more recently, as snail homologue 3 (Snai3)...
  5. pmc Overexpression of Snai3 suppresses lymphoid- and enhances myeloid-cell differentiation
    Timothy Dahlem
    Division of Cell Biology and Immunology, Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT 84112, USA
    Eur J Immunol 42:1038-43. 2012
    ..The role of the transcriptional repressor Snai3 protein in the derivation of cells of the hemato-poietic system was investigated...
  6. pmc Deletion of Snai2 and Snai3 results in impaired physical development compounded by lymphocyte deficiency
    Peter D Pioli
    The Division of Cell Biology and Immunology, Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah, United States of America
    PLoS ONE 8:e69216. 2013
    ..Less is known about the third member of the family, Snai3. To investigate the function of Snai3, we generated a conditional knockin mouse...
  7. pmc Fatal autoimmunity results from the conditional deletion of Snai2 and Snai3
    Peter D Pioli
    Division of Cell Biology and Immunology, Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT 84132, United States Electronic address
    Cell Immunol 295:1-18. 2015
    ..Using the germ line deletion of Snai2 combined with the hematopoietic specific deletion of Snai3, we report that these factors function redundantly to preserve the development of B and T cells...
  8. doi Directed Dedifferentiation Using Partial Reprogramming Induces Invasive Phenotype in Melanoma Cells
    Nathalie Knappe
    Skin Cancer Unit, German Cancer Research Center DKFZ, Heidelberg, Germany
    Stem Cells 34:832-46. 2016
    ..Additionally, using global gene expression analysis of partially reprogrammed cells, we identified SNAI3 as a novel invasion-related marker in human melanoma...
  9. pmc Snai2 and Snai3 transcriptionally regulate cellular fitness and functionality of T cell lineages through distinct gene programs
    Peter D Pioli
    Division of Cell Biology and Immunology, Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT 84132, United States Electronic address
    Immunobiology 221:618-33. 2016
    ..Previously, we identified Snai2 and Snai3 as being essential regulators of immune tolerance partly due to the impaired function of CD4(+) regulatory T cells ..
  10. pmc The snail family gene snai3 is not essential for embryogenesis in mice
    Cara K Bradley
    Center for Molecular Medicine, Maine Medical Center Research Institute, Scarborough, Maine, United States of America
    PLoS ONE 8:e65344. 2013
    ..Three members of the Snail gene family have been described in mammals, encoded by the Snai1, Snai2, and Snai3 genes...
  11. ncbi Expression of Snail protein in tumor-stroma interface
    C Franci
    Unitat de Biologia Cellular i Molecular, Institut Municipal d Investigacio Medica, Universitat Pompeu Fabra, Barcelona, Spain
    Oncogene 25:5134-44. 2006
    ..These results demonstrate that Snail is present in activated mesenchymal cells, indicate its relevance in the communication between tumor and stroma and suggest that it can promote the conversion of carcinoma cells to stromal cells...
  12. ncbi Transcriptional control of Pactolus: evidence of a negative control region and comparison with its evolutionary paralogue, CD18 (beta2 integrin)
    J Scott Hale
    Division of Cell Biology and Immunology, Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah 84132, USA
    J Leukoc Biol 80:383-98. 2006
    ..against these proteins, using extracts from macrophages and mucosal mast cells, identified specific binding of Smuc to the promoter element, including a Smuc/PU.1/DNA trimeric complex...
  13. doi p53 inhibits tumor cell invasion via the degradation of snail protein in hepatocellular carcinoma
    Seung Oe Lim
    Department of Biological Sciences, Seoul National University, Seoul, Republic of Korea
    FEBS Lett 584:2231-6. 2010
    ..These findings contribute to a better understanding of the role of p53 mutation and Snail overexpression as a late event in hepatocarcinogenesis...
  14. doi Neurogenin3 initiates stepwise delamination of differentiating endocrine cells during pancreas development
    Mathieu Gouzi
    Swiss Institute for Experimental Cancer Research ISREC, School of Life Sciences, Ecole Polytechnique Federale de Lausanne EPFL, Lausanne, Switzerland
    Dev Dyn 240:589-604. 2011
    ..In the chick embryo, Ngn3 independently controls epithelium delamination and differentiation programs. Developmental Dynamics 240:589-604, 2011. © 2011 Wiley-Liss, Inc...