Smpx

Summary

Gene Symbol: Smpx
Description: small muscle protein, X-linked
Alias: 1010001C09Rik, Csl, small muscular protein, cardiac and skeletal muscle protein, chisel protein, stretch-responsive skeletal muscle protein
Species: mouse

Top Publications

  1. ncbi Identification, mapping, and genomic structure of a novel X-chromosomal human gene (SMPX) encoding a small muscular protein
    D Patzak
    Institute of Human Genetics, Ernst Moritz Arndt University Greifswald, Germany
    Hum Genet 105:506-12. 1999
  2. ncbi Muscle costameric protein, Chisel/Smpx, associates with focal adhesion complexes and modulates cell spreading in vitro via a Rac1/p38 pathway
    Aaron Schindeler
    Developmental Biology Program, Victor Chang Cardiac Research Institute, 384 Victoria Street, Darlinghurst NSW 2010, Australia
    Exp Cell Res 307:367-80. 2005
  3. ncbi Chamber formation and morphogenesis in the developing mammalian heart
    V M Christoffels
    Department of Anatomy and Embryology, Academic Medical Center, University of Amsterdam, Amsterdam, 1105, The Netherlands
    Dev Biol 223:266-78. 2000
  4. pmc The small muscle-specific protein Csl modifies cell shape and promotes myocyte fusion in an insulin-like growth factor 1-dependent manner
    S Palmer
    Victor Chang Cardiac Research Institute, 384 Victoria Street, Darlinghurst, NSW 2010, Australia
    J Cell Biol 153:985-98. 2001
  5. ncbi Identification of a novel stretch-responsive skeletal muscle gene (Smpx)
    T J Kemp
    Molecular Pathology, Imperial College of Science, Technology, and Medicine, London, SW7 2AZ, United Kingdom
    Genomics 72:260-71. 2001
  6. pmc Overexpression of SMPX in adult skeletal muscle does not change skeletal muscle fiber type or size
    Einar Eftestøl
    Department of Biosciences, University of Oslo, Oslo, Norway
    PLoS ONE 9:e99232. 2014
  7. doi A systematic survey of carbonic anhydrase mRNA expression during mammalian inner ear development
    Ling Wu
    Department of Anatomy, Yonsei University College of Medicine, Seoul, South Korea
    Dev Dyn 242:269-80. 2013
  8. pmc Role of Hand1/eHAND in the dorso-ventral patterning and interventricular septum formation in the embryonic heart
    Kiyonori Togi
    Department of Social Service, Kyoto University Hospital, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
    Mol Cell Biol 24:4627-35. 2004
  9. ncbi Foxh1 is essential for development of the anterior heart field
    Ingo Von Both
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada
    Dev Cell 7:331-45. 2004
  10. ncbi Tbx2 is essential for patterning the atrioventricular canal and for morphogenesis of the outflow tract during heart development
    Zachary Harrelson
    Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Development 131:5041-52. 2004

Scientific Experts

  • Hiroki Kokubo
  • Makoto Tanaka
  • T J Kemp
  • Richard P Harvey
  • Einar Eftestøl
  • Zachary Harrelson
  • Ling Wu
  • Jinwoong Bok
  • Heejei Yoon
  • Beth A Firulli
  • Donna Lai
  • Karim Mesbah
  • Lanying Song
  • Kai Jiao
  • Jin Wen Chen
  • S Palmer
  • Virginia E Papaioannou
  • Catherine A Risebro
  • Robert G Kelly
  • Aaron Schindeler
  • Chen Leng Cai
  • Michael D Schneider
  • Lijiang Ma
  • Hanying Chen
  • Ingo Von Both
  • Kiyonori Togi
  • Vincent M Christoffels
  • Jo C Bruusgaard
  • Tine Norman Alver
  • Kristian Gundersen
  • Borum Sagong
  • Jae Young Choi
  • Un Kyung Kim
  • C Biben
  • Dong Jin Lee
  • Myoung Hee Kim
  • R P Harvey
  • David P McConville
  • Mingdong Zhou
  • Lynne Hartley
  • Jan Michalicek
  • Ishtiaq Ahmed
  • Anthony B Firulli
  • Alistair N Garratt
  • V M Christoffels
  • Lorraine Robb
  • James S Byers
  • Orit Wolstein
  • Michael P Feneley
  • Ariel Forrai
  • Xifu Liu
  • Carmen Birchmeier
  • Joshua W Vincentz
  • Diane Fatkin
  • Ralston M Barnes
  • D Patzak
  • Magali Théveniau-Ruissy
  • Qin Wang
  • Xinbin Chen
  • Chu Xia Deng
  • Wensheng Yan
  • H Scott Baldwin
  • Paul R Riley
  • Jeffrey M Bergelson
  • Ross Breckenridge
  • Timothy J Mohun
  • Sangyoon J Shin
  • Nicola Smart
  • Laurent Dupays
  • Bin Zhou
  • Qian Chun Yu
  • Lopeti Lavulo
  • Michael G Rosenfeld
  • Ju Chen
  • Xiaodong Li
  • Sylvia Evans
  • Lei Bu
  • James F Martin
  • Mei Fang Lu
  • Yibing Qyang
  • Lei Yang
  • Xiaoxue Zhang
  • Wenlai Zhou
  • Robert J Schwartz
  • Johnathon R Walls
  • Willem M H Hoogaars
  • Cristoforo Silvestri
  • Shideng Bao
  • Roni J Bollag
  • Alessandra Tessari

Detail Information

Publications22

  1. ncbi Identification, mapping, and genomic structure of a novel X-chromosomal human gene (SMPX) encoding a small muscular protein
    D Patzak
    Institute of Human Genetics, Ernst Moritz Arndt University Greifswald, Germany
    Hum Genet 105:506-12. 1999
    ..Thus, a novel human gene encoding a small muscular protein that maps to Xp22...
  2. ncbi Muscle costameric protein, Chisel/Smpx, associates with focal adhesion complexes and modulates cell spreading in vitro via a Rac1/p38 pathway
    Aaron Schindeler
    Developmental Biology Program, Victor Chang Cardiac Research Institute, 384 Victoria Street, Darlinghurst NSW 2010, Australia
    Exp Cell Res 307:367-80. 2005
    The murine X-linked gene Chisel (Csl/Smpx) encodes a 9-kDa protein that associates in heart and skeletal muscle cells with the costameric cytoskeleton, implicated in maintaining muscle integrity and responses to biomechanical stress...
  3. ncbi Chamber formation and morphogenesis in the developing mammalian heart
    V M Christoffels
    Department of Anatomy and Embryology, Academic Medical Center, University of Amsterdam, Amsterdam, 1105, The Netherlands
    Dev Biol 223:266-78. 2000
    ....
  4. pmc The small muscle-specific protein Csl modifies cell shape and promotes myocyte fusion in an insulin-like growth factor 1-dependent manner
    S Palmer
    Victor Chang Cardiac Research Institute, 384 Victoria Street, Darlinghurst, NSW 2010, Australia
    J Cell Biol 153:985-98. 2001
    We have isolated a murine cDNA encoding a 9-kD protein, Chisel (Csl), in a screen for transcriptional targets of the cardiac homeodomain factor Nkx2-5...
  5. ncbi Identification of a novel stretch-responsive skeletal muscle gene (Smpx)
    T J Kemp
    Molecular Pathology, Imperial College of Science, Technology, and Medicine, London, SW7 2AZ, United Kingdom
    Genomics 72:260-71. 2001
    ..This gene has been called "small muscle protein (X chromosome)" (Smpx; HGMW-approved human gene symbol SMPX) and we hypothesize that it plays a role in skeletal muscle hypertrophy.
  6. pmc Overexpression of SMPX in adult skeletal muscle does not change skeletal muscle fiber type or size
    Einar Eftestøl
    Department of Biosciences, University of Oslo, Oslo, Norway
    PLoS ONE 9:e99232. 2014
    ..Small muscle protein X-linked (SMPX) is upregulated by stretch in skeletal muscle and has been suggested to serve both as a transcription factor and a ..
  7. doi A systematic survey of carbonic anhydrase mRNA expression during mammalian inner ear development
    Ling Wu
    Department of Anatomy, Yonsei University College of Medicine, Seoul, South Korea
    Dev Dyn 242:269-80. 2013
    ..To understand the specific roles of CA isozymes in the inner ear, a systematic survey was conducted to reveal temporal and spatial expression patterns of all 16 CA isozymes during inner ear development...
  8. pmc Role of Hand1/eHAND in the dorso-ventral patterning and interventricular septum formation in the embryonic heart
    Kiyonori Togi
    Department of Social Service, Kyoto University Hospital, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
    Mol Cell Biol 24:4627-35. 2004
    ..Furthermore, Hand1/eHAND is not a master regulatory gene that specifies the left ventricle myocyte lineage but may control the dorso-ventral patterning in concert with additional genes...
  9. ncbi Foxh1 is essential for development of the anterior heart field
    Ingo Von Both
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada
    Dev Cell 7:331-45. 2004
    ..Thus, Foxh1 and Nkx2-5 functionally interact and are essential for development of the AHF and its derivatives, the RV and OFT, in response to TGFbeta-like signals...
  10. ncbi Tbx2 is essential for patterning the atrioventricular canal and for morphogenesis of the outflow tract during heart development
    Zachary Harrelson
    Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Development 131:5041-52. 2004
    ....
  11. ncbi T-box genes coordinate regional rates of proliferation and regional specification during cardiogenesis
    Chen Leng Cai
    Skaggs School of Pharmacy, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Development 132:2475-87. 2005
    ....
  12. pmc BMP10 is essential for maintaining cardiac growth during murine cardiogenesis
    Hanying Chen
    Herman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Development 131:2219-31. 2004
    ..This may provide an underlying mechanism for understanding the pathogenesis of both structural and functional congenital heart defects...
  13. ncbi Bmp2 is essential for cardiac cushion epithelial-mesenchymal transition and myocardial patterning
    Lijiang Ma
    Institute of Biosciences and Technology, Texas A and M University System Health Science Center, 2121 West Holcombe Boulevard, Houston, TX 77030, USA
    Development 132:5601-11. 2005
    ..Our data indicate that Bmp2 has a crucial role in coordinating multiple aspects of AV canal morphogenesis...
  14. ncbi Cardiomyocyte-specific deletion of the coxsackievirus and adenovirus receptor results in hyperplasia of the embryonic left ventricle and abnormalities of sinuatrial valves
    Jin Wen Chen
    Division of Infectious Diseases, Children s Hospital of Philadelphia, Philadelphia, USA
    Circ Res 98:923-30. 2006
    ..In addition, the results suggest that CAR-mediated intercellular contacts may regulate proliferation and differentiation of cardiomyocytes within the embryonic left ventricular wall...
  15. ncbi Hand1 regulates cardiomyocyte proliferation versus differentiation in the developing heart
    Catherine A Risebro
    Molecular Medicine Unit, UCL Institute of Child Health, London WC1N 1EH, UK
    Development 133:4595-606. 2006
    ....
  16. ncbi Hesr1 and Hesr2 regulate atrioventricular boundary formation in the developing heart through the repression of Tbx2
    Hiroki Kokubo
    Division of Mammalian Development, National Institute of Genetics, 1111 Yata, Mishima Shizuoka 411 8540, Japan
    Development 134:747-55. 2007
    ..Furthermore, we find that the expression of Hesr1 and Hesr2 is independent of Notch2 signaling. Taken together, our data demonstrate that Hesr1 and Hesr2 play crucial roles in AV boundary formation through the suppression of Tbx2...
  17. pmc Myocardial smad4 is essential for cardiogenesis in mouse embryos
    Lanying Song
    Department of Genetics, Division of Genetic and Translational Medicine, The University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Circ Res 101:277-85. 2007
    ..In conclusion, this study provides the first mouse model showing that Smad4 plays essential roles during cardiogenesis...
  18. pmc Tbx3 is required for outflow tract development
    Karim Mesbah
    Developmental Biology Institute of Marseilles Luminy, France
    Circ Res 103:743-50. 2008
    ....
  19. doi Neuregulin 1 sustains the gene regulatory network in both trabecular and nontrabecular myocardium
    Donna Lai
    Victor Chang Cardiac Research Institute, Lowy Packer Building, 405 Liverpool St, Darlinghurst 2010, Australia
    Circ Res 107:715-27. 2010
    ..In development, the membrane-tethered signaling ligand Neuregulin (Nrg)1, expressed in endocardium, is essential for ventricular morphogenesis. In adults, Nrg1 protects against heart failure and can induce cardiomyocytes to divide...
  20. pmc Analysis of a Hand1 hypomorphic allele reveals a critical threshold for embryonic viability
    Beth A Firulli
    Riley Heart Research Center, Herman B Wells Center for Pediatric Research Division of Pediatrics Cardiology, Departments of Anatomy and Medical and Molecular Genetics, Indiana Medical School, Indianapolis, Indiana 46202 5225, USA
    Dev Dyn 239:2748-60. 2010
    ..Together, these data define a critical threshold of Hand1 expression that is necessary for embryonic survival...
  21. pmc Identification of genes concordantly expressed with Atoh1 during inner ear development
    Heejei Yoon
    Department of Anatomy, Brain Korea 21 Project for Medical Science, College of Medicine, Yonsei University, Seoul, Korea
    Anat Cell Biol 44:69-78. 2011
    ..identified many other genes that have not been associated with hair cell differentiation, including Tekt2, Spag6, Smpx, Lmod1, Myh7b, Kif9, Ttyh1, Scn11a and Cnga2...
  22. ncbi T-box transcription factor Tbx2 represses differentiation and formation of the cardiac chambers
    Vincent M Christoffels
    Experimental and Molecular Cardiology Group, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Dev Dyn 229:763-70. 2004
    ..These findings provide the first evidence that Tbx2 is a determinant in the local repression of chamber-specific gene expression and chamber differentiation...