Smad3

Summary

Gene Symbol: Smad3
Description: SMAD family member 3
Alias: AU022421, Madh3, mothers against decapentaplegic homolog 3, MAD homolog 3, Smad 3, mMad3, mad3, mothers against DPP homolog 3
Species: mouse

Top Publications

  1. pmc Smad3 reduces susceptibility to hepatocarcinoma by sensitizing hepatocytes to apoptosis through downregulation of Bcl-2
    Yu An Yang
    Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA
    Cancer Cell 9:445-57. 2006
  2. doi Targeted disruption of Smad3 confers resistance to the development of dimethylnitrosamine-induced hepatic fibrosis in mice
    Giovanni Latella
    Department of Internal Medicine, GI Unit, University of L Aquila, L Aquila, Italy
    Liver Int 29:997-1009. 2009
  3. ncbi TGF-beta signal transduction
    J Massague
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Annu Rev Biochem 67:753-91. 1998
  4. pmc Notch receptors and Smad3 signaling cooperate in the induction of interleukin-9-producing T cells
    Wassim Elyaman
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Immunity 36:623-34. 2012
  5. ncbi Combinatorial activities of Smad2 and Smad3 regulate mesoderm formation and patterning in the mouse embryo
    N Ray Dunn
    Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
    Development 131:1717-28. 2004
  6. pmc Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-beta
    X Yang
    Genetics of Development and Disease Branch, 10 9N105, NIDDK, National Institutes of Health, Bethesda, MD 20892, USA
    EMBO J 18:1280-91. 1999
  7. ncbi TGF-beta signaling is dynamically regulated during the alveolarization of rodent and human lungs
    Miguel A Alejandre-Alcázar
    Department of Internal Medicine, University of Giessen Lung Center, Justus Liebig University, Giessen, Germany
    Dev Dyn 237:259-69. 2008
  8. pmc Cox-2 inactivates Smad signaling and enhances EMT stimulated by TGF-beta through a PGE2-dependent mechanisms
    Jason R Neil
    Department of Pharmacology, University of Colorado Health Sciences Center, Aurora, CO 80045, USA
    Carcinogenesis 29:2227-35. 2008
  9. pmc Remodeling of chromatin structure within the promoter is important for bmp-2-induced fgfr3 expression
    Fenyong Sun
    Institute of Genetic Engineering, Jinan University, PR China
    Nucleic Acids Res 37:3897-911. 2009
  10. pmc TGF-beta signalling is regulated by Schnurri-2-dependent nuclear translocation of CLIC4 and consequent stabilization of phospho-Smad2 and 3
    Anjali Shukla
    Laboratory of Cancer Biology and Genetics, 37 Convent Drive, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Nat Cell Biol 11:777-84. 2009

Research Grants

Detail Information

Publications158 found, 100 shown here

  1. pmc Smad3 reduces susceptibility to hepatocarcinoma by sensitizing hepatocytes to apoptosis through downregulation of Bcl-2
    Yu An Yang
    Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA
    Cancer Cell 9:445-57. 2006
    ..We report here that forced expression of a major TGF-beta signaling transducer, Smad3, reduces susceptibility to HCC in a chemically induced murine model...
  2. doi Targeted disruption of Smad3 confers resistance to the development of dimethylnitrosamine-induced hepatic fibrosis in mice
    Giovanni Latella
    Department of Internal Medicine, GI Unit, University of L Aquila, L Aquila, Italy
    Liver Int 29:997-1009. 2009
    ..Transforming growth factor-beta (TGF-beta)/Smad3 signalling plays a central role in tissue fibrogenesis, acting as a potent stimulus of ECM accumulation.
  3. ncbi TGF-beta signal transduction
    J Massague
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Annu Rev Biochem 67:753-91. 1998
    ..Mutations in these pathways are the cause of various forms of human cancer and developmental disorders...
  4. pmc Notch receptors and Smad3 signaling cooperate in the induction of interleukin-9-producing T cells
    Wassim Elyaman
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Immunity 36:623-34. 2012
    ..Notch1 intracellular domain (NICD1) recruited Smad3, downstream of TGF-β cytokine signaling, and together with recombining binding protein (RBP)-Jκ bound the Il9 ..
  5. ncbi Combinatorial activities of Smad2 and Smad3 regulate mesoderm formation and patterning in the mouse embryo
    N Ray Dunn
    Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
    Development 131:1717-28. 2004
    TGFbeta/activin/Nodal receptors activate both Smad2 and Smad3 intracellular effector proteins. The functional activities of these closely related molecules have been extensively studied in cell lines...
  6. pmc Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-beta
    X Yang
    Genetics of Development and Disease Branch, 10 9N105, NIDDK, National Institutes of Health, Bethesda, MD 20892, USA
    EMBO J 18:1280-91. 1999
    b>SMAD3 is one of the intracellular mediators that transduces signals from transforming growth factor-beta (TGF-beta) and activin receptors...
  7. ncbi TGF-beta signaling is dynamically regulated during the alveolarization of rodent and human lungs
    Miguel A Alejandre-Alcázar
    Department of Internal Medicine, University of Giessen Lung Center, Justus Liebig University, Giessen, Germany
    Dev Dyn 237:259-69. 2008
    ..of the TGF-beta receptors Acvrl1, Tgfbr1, Tgfbr2, Tgfbr3, and endoglin, and the intracellular messengers Smad2, Smad3, Smad4, Smad6, and Smad7 were noted as mouse and human lungs progressed through the canalicular, saccular, and ..
  8. pmc Cox-2 inactivates Smad signaling and enhances EMT stimulated by TGF-beta through a PGE2-dependent mechanisms
    Jason R Neil
    Department of Pharmacology, University of Colorado Health Sciences Center, Aurora, CO 80045, USA
    Carcinogenesis 29:2227-35. 2008
    ....
  9. pmc Remodeling of chromatin structure within the promoter is important for bmp-2-induced fgfr3 expression
    Fenyong Sun
    Institute of Genetic Engineering, Jinan University, PR China
    Nucleic Acids Res 37:3897-911. 2009
    ..Collectively, our study results suggest a model for BMP-2-induced FGFR3 expression in which the core promoter architecture is specifically regulated...
  10. pmc TGF-beta signalling is regulated by Schnurri-2-dependent nuclear translocation of CLIC4 and consequent stabilization of phospho-Smad2 and 3
    Anjali Shukla
    Laboratory of Cancer Biology and Genetics, 37 Convent Drive, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Nat Cell Biol 11:777-84. 2009
    ..Nuclear CLIC4 associates with phospho (p)-Smad2 and p-Smad3, protecting them from dephosphorylation by nuclear phosphatases...
  11. ncbi Receptor-associated Mad homologues synergize as effectors of the TGF-beta response
    Y Zhang
    Department of Growth and Development, University of California at San Francisco, 94143 0640, USA
    Nature 383:168-72. 1996
    ..These results define hMAD-3 and -4 as effectors of the TGF-beta response and demonstrate a function for DPCA-4/hMAD-4 as a tumour suppressor...
  12. ncbi Smad2 and Smad3 positively and negatively regulate TGF beta-dependent transcription through the forkhead DNA-binding protein FAST2
    E Labbe
    Department of Anatomy and Cell Biology, University of Toronto, Ontario, Canada
    Mol Cell 2:109-20. 1998
    ..b>Smad3 is closely related to Smad2 but suppresses activation of the gsc promoter...
  13. ncbi Smad3 mutant mice develop metastatic colorectal cancer
    Y Zhu
    Center for Developmental Biology, UT Southwestern Medical Center, Dallas, Texas 75235 9133, USA
    Cell 94:703-14. 1998
    ..TGFbeta transduces its signal to the interior of the cell via Smad2, Smad3, and Smad4. We report the cloning and targeted disruption of the mouse Smad3 gene...
  14. pmc Targeted disruption of Smad3 reveals an essential role in transforming growth factor beta-mediated signal transduction
    M B Datto
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Mol Cell Biol 19:2495-504. 1999
    ..To discern the in vivo functions of one of these Smads, Smad3, we generated mice harboring a targeted disruption of this gene...
  15. ncbi Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response
    G S Ashcroft
    Laboratory of Cell Regulation and Carcinogenesis, NCI, Bethesda, Maryland 20892 5055, USA
    Nat Cell Biol 1:260-6. 1999
    ..that, in contrast to predictions made on the basis of the ability of exogenous TGF-beta to improve wound healing, Smad3-null (Smad3ex8/ex8) mice paradoxically show accelerated cutaneous wound healing compared with wild-type mice, ..
  16. ncbi Functions of mammalian Smad genes as revealed by targeted gene disruption in mice
    M Weinstein
    Genetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 10 9N105, 10 Center Drive, Bethesda, MD 20892, USA
    Cytokine Growth Factor Rev 11:49-58. 2000
    ..These experiments have shown that Smad2 and Smad4 are needed for gastrulation, Smad5 for angiogenesis, and Smad3 for establishment of the mucosal immune response and proper development of the skeleton...
  17. pmc TGF-beta/Smad3 signals repress chondrocyte hypertrophic differentiation and are required for maintaining articular cartilage
    X Yang
    Genetics of Development and Disease Branch, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Cell Biol 153:35-46. 2001
    ..In this study, we showed that TGF-beta/Smad3 signals inhibit terminal hypertrophic differentiation of chondrocyte and are essential for maintaining articular ..
  18. pmc TGF-beta inhibits muscle differentiation through functional repression of myogenic transcription factors by Smad3
    D Liu
    Department of Growth and Development, University of California at San Francisco, 94143, USA
    Genes Dev 15:2950-66. 2001
    ..Here we show that the TGF-beta intracellular effector Smad3, but not Smad2, mediates the inhibition of myogenic differentiation in MyoD-expressing C3H10T1/2 cells and C2C12 ..
  19. ncbi Transforming growth factor-beta inhibits adipocyte differentiation by Smad3 interacting with CCAAT/enhancer-binding protein (C/EBP) and repressing C/EBP transactivation function
    Lisa Choy
    Department of Growth and Development, Programs in Cell Biology and Developmental Biology, University of California, San Francisco, California 94143 0640, USA
    J Biol Chem 278:9609-19. 2003
    ..Because TGF-beta inhibits adipogenesis by signaling through Smad3, we examined physical and functional interactions of Smad3 and Smad4 with C/EBPbeta, C/EBPdelta, and PPARgamma2...
  20. ncbi Smad3 is required for enamel biomineralization
    Masahiko Yokozeki
    Department of Orthodontics, School of Dentistry, The University of Tokushima, 3 18 15 Kuramoto cho, Tokushima 770 8504, Japan
    Biochem Biophys Res Commun 305:684-90. 2003
    b>Smad3 is an intracellular signaling molecule that mediates the signal from transforming growth factor-beta (TGF-beta) and activin receptors...
  21. ncbi Mice lacking Smad3 are protected against streptozotocin-induced diabetic glomerulopathy
    Masaki Fujimoto
    Department of Clinical Cell Biology and Medicine, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chiba 260 8670, Japan
    Biochem Biophys Res Commun 305:1002-7. 2003
    ..In order to evaluate a role of Smad3, one of the major signaling molecules downstream of TGF-beta, in the pathogenesis of diabetic glomerulopathy, ..
  22. ncbi TGF-beta3-dependent SMAD2 phosphorylation and inhibition of MEE proliferation during palatal fusion
    Xiao Mei Cui
    Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, Los Angeles, California 90033, USA
    Dev Dyn 227:387-94. 2003
    ..SMAD2 and SMAD3 were both present in the MEE, whereas SMAD2 was the only one phosphorylated during palatal fusion...
  23. pmc Targeted disruption of TGF-beta1/Smad3 signaling protects against renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction
    Misako Sato
    Department of Pathology, Wakayama Medical University, Wakayama, Japan
    J Clin Invest 112:1486-94. 2003
    ..We now show that mice lacking Smad3 (Smad3ex8/ex8), a key signaling intermediate downstream of the TGF-beta receptors, are protected against ..
  24. pmc Interference with transforming growth factor-beta/ Smad3 signaling results in accelerated healing of wounds in previously irradiated skin
    Kathleen C Flanders
    Laboratory of Cell Regulation and Carcinogenesis and the Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 21201, USA
    Am J Pathol 163:2247-57. 2003
    ..We previously showed that epithelialization of incisional wounds is accelerated in mice null for Smad3, a key cytoplasmic mediator of TGF-beta signaling...
  25. ncbi Aberrant Toll receptor expression and endotoxin hypersensitivity in mice lacking a functional TGF-beta 1 signaling pathway
    Nancy McCartney-Francis
    Cellular Immunology Section, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 172:3814-21. 2004
    ..TLR4 mRNA expression observed in TGF-beta1 null mice as well as in mice lacking the TGF-beta transcription factor Smad3 was associated with LPS hyperresponsiveness leading to increased expression of inflammatory cytokines and NO and ..
  26. ncbi Smad3 is essential for TGF-beta 1 to suppress IL-2 production and TCR-induced proliferation, but not IL-2-induced proliferation
    Susan C McKarns
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48824 USA
    J Immunol 172:4275-84. 2004
    ..We used Smad3(-/-) mice to investigate a role for Smad3 in IL-2 production and proliferation in T cells...
  27. ncbi Menin is required for bone morphogenetic protein 2- and transforming growth factor beta-regulated osteoblastic differentiation through interaction with Smads and Runx2
    Hideaki Sowa
    Division of Endocrinology Metabolism, Neurology and Hematology Oncology, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, Kobe 6500017, Japan
    J Biol Chem 279:40267-75. 2004
    ..In the osteoblast MC3T3-E1 cells, transforming growth factor-beta and its signaling molecule, Smad3, negatively regulated Runx2 transcriptional activity...
  28. ncbi Cyclin-dependent kinases regulate the antiproliferative function of Smads
    Isao Matsuura
    Center for Advanced Biotechnology and Medicine, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA
    Nature 430:226-31. 2004
    Transforming growth factor-beta (TGF-beta) potently inhibits cell cycle progression at the G1 phase. Smad3 has a key function in mediating the TGF-beta growth-inhibitory response...
  29. ncbi Smad3 deficiency attenuates renal fibrosis, inflammation,and apoptosis after unilateral ureteral obstruction
    Kumi Inazaki
    Atopy Allergy Research Center, Juntendo University School of Medicine, Tokyo, Japan
    Kidney Int 66:597-604. 2004
    ..In this study, we sought to determine whether Smad3, a major signaling component of TGF-beta, mediated renal fibrosis induced by UUO.
  30. ncbi Smad3 null mice develop airspace enlargement and are resistant to TGF-beta-mediated pulmonary fibrosis
    Philippe Bonniaud
    Department of Pathology and Molecular Medicine, Centre for Gene Therapeutics, McMaster University, Hamilton, Canada
    J Immunol 173:2099-108. 2004
    ..matrix (ECM) gene expression through a series of intracellular signaling molecules, including Smad2 and Smad3. We show that Smad3 null mice (knockout (KO)) develop progressive age-related increases in the size of alveolar ..
  31. pmc Essential role of Smad3 in the inhibition of inflammation-induced PPARbeta/delta expression
    Nguan Soon Tan
    Center for Integrative Genomics, NCCR Frontiers in Genetics, University of Lausanne, 1015 Lausanne, Switzerland
    EMBO J 23:4211-21. 2004
    ..Whereas conditions that mimic the initial inflammatory events stimulate PPARbeta/delta expression, TGF-beta1/Smad3 suppresses this inflammation-induced PPARbeta/delta transcription, as seen in the late re-epithelialization/..
  32. pmc NEDD4-2 (neural precursor cell expressed, developmentally down-regulated 4-2) negatively regulates TGF-beta (transforming growth factor-beta) signalling by inducing ubiquitin-mediated degradation of Smad2 and TGF-beta type I receptor
    Go Kuratomi
    Department of Biochemistry, the Cancer Institute of the Japanese Foundation for Cancer Research JFCR, 1 37 1 Kami Ikebukuro, Toshima ku, Tokyo 170 8455, Japan
    Biochem J 386:461-70. 2005
    ..TGF-beta-specific R-Smads, Smads 2 and 3, in a ligand-dependent manner, and induced degradation of Smad2, but not Smad3. However, in contrast with Smurf2, NEDD4-2 failed to induce ubiquitination of SnoN (Ski-related novel protein N), ..
  33. pmc Repression of Runx2 function by TGF-beta through recruitment of class II histone deacetylases by Smad3
    Jong Seok Kang
    Department of Cell and Tissue Biology, Department of Anatomy, Programs in Cell Biology and Developmental Biology, University of California, San Francisco, CA 94143 0512, USA
    EMBO J 24:2543-55. 2005
    ..factor-beta (TGF-beta) inhibits osteoblast differentiation through inhibition of the function of Runx2 (Cbfa1) by Smad3. The mechanism through which TGF-beta/Smad3 inhibits Runx2 function has not been characterized...
  34. ncbi Hyperactivation of Stat3 in gp130 mutant mice promotes gastric hyperproliferation and desensitizes TGF-beta signaling
    Brendan J Jenkins
    Ludwig Institute for Cancer Research, Parkville, VIC 3050, Australia
    Nat Med 11:845-52. 2005
    ....
  35. pmc Deletion of Smad2 in mouse liver reveals novel functions in hepatocyte growth and differentiation
    Wenjun Ju
    Department of Medicine, Mount Sinai School of Medicine, One Gustave L Levy Pl, Box 1118, New York, New York 10029, USA
    Mol Cell Biol 26:654-67. 2006
    Smad family proteins Smad2 and Smad3 are activated by transforming growth factor beta (TGF-beta)/activin/nodal receptors and mediate transcriptional regulation...
  36. pmc Helicobacter infection is required for inflammation and colon cancer in SMAD3-deficient mice
    Lillian Maggio-Price
    Department of Comparative Medicine, University of Washington, 1959 Northeast Pacific Avenue, Seattle, WA 98195, USA
    Cancer Res 66:828-38. 2006
    ..Although others have reported that mice deficient in the TGF-beta signaling molecule SMAD3 develop colon cancer, we found that SMAD3-deficient mice maintained free of the Gram-negative enterohepatic ..
  37. pmc Smad3 deficiency alters key structural elements of the extracellular matrix and mechanotransduction of wound closure
    Praveen R Arany
    Laboratory of Cell Regulation and Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 103:9250-5. 2006
    The loss of TGFbeta or its downstream mediator, Smad3, key players in tissue repair, accelerates closure of incisional wounds in mice...
  38. ncbi Requirement of Smad3 for mast cell growth
    Masayuki Funaba
    Laboratory of Nutrition, Azabu University School of Veterinary Medicine, 1 17 71 Fuchinobe, Sagamihara, Japan
    Cell Immunol 240:47-52. 2006
    ..Doubling time of BMMC from Smad3-null mice was longer than that from wild-type (WT) mice, and the differences tended to be larger with time of ..
  39. pmc Essential function of HIPK2 in TGFbeta-dependent survival of midbrain dopamine neurons
    Jiasheng Zhang
    Department of Pathology, University of California San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143, USA
    Nat Neurosci 10:77-86. 2007
    ..These data underscore the importance of the TGFbeta-Smad-HIPK2 pathway in the survival of DA neurons and its potential as a therapeutic target for promoting DA neuron survival during neurodegeneration...
  40. ncbi Targeted imaging of colonic tumors in smad3-/- mice discriminates cancer and inflammation
    Natasha G Deane
    Department of Surgery and Division of Surgical Oncology, Vanderbilt University, Nashville, TN 37235, USA
    Mol Cancer Res 5:341-9. 2007
    ..NIR-conPK11195 localized and was retained in colonic adenomas and carcinomas in Smad3(-/-) mice but not in non-neoplastic hamartomas or chronically inflamed colonic tissue...
  41. ncbi Inhibition of allergen-induced airway remodeling in Smad 3-deficient mice
    Annie V Le
    Division of Allergy and Immunology, Scripps Clinic and Research Institute, La Jolla, CA 92037, USA
    J Immunol 178:7310-6. 2007
    Intracellular signaling pathways that converge on Smad 3 are used by both TGF-beta and activin A, key cytokines implicated in the process of fibrogenesis...
  42. ncbi Interference with TGF-beta signaling by Smad3-knockout in mice limits diabetic glomerulosclerosis without affecting albuminuria
    Amy Wang
    Division of Nephrology, Northwestern University, 303 E Chicago Ave, Tarry 4 755, Chicago, IL 60611, USA
    Am J Physiol Renal Physiol 293:F1657-65. 2007
    ..To isolate the contribution of one of the signaling pathways of TGF-beta, the Smad3 gene in the mouse was knocked out at exons 2 and 3, and the effect was studied in streptozotocin (STZ)-induced ..
  43. ncbi Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancer
    Yukiko Tone
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Nat Immunol 9:194-202. 2008
    ..The transcription factors Smad3 and NFAT are required for activity of this Foxp3 enhancer, and both factors are essential for histone acetylation ..
  44. doi Enhanced BMP signaling results in supernumerary tooth formation in USAG-1 deficient mouse
    Akiko Murashima-Suginami
    Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Kyoto University, Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
    Biochem Biophys Res Commun 369:1012-6. 2008
    ..Based upon these results, we conclude that enhanced BMP signaling results in supernumerary teeth and BMP signaling was modulated by Wnt signaling in the USAG-1 deficient mouse model...
  45. pmc Transforming growth factor-beta-regulated miR-24 promotes skeletal muscle differentiation
    Qiang Sun
    State Key Laboratory of Proteomics, Genetic Laboratory of Development and Diseases, Institute of Biotechnology, 20 Dongdajie, Beijing 100071, PR China
    Nucleic Acids Res 36:2690-9. 2008
    ..blot analysis, we showed that TGF-beta1 repressed miR-24 transcription which was dependent on the presence of Smad3 and a Smads binding site in the promoter region of miR-24...
  46. doi Brain area-specific effect of TGF-beta signaling on Wnt-dependent neural stem cell expansion
    Sven Falk
    Institute of Cell Biology, ETH Honggerberg, CH 8093 Zurich, Switzerland
    Cell Stem Cell 2:472-83. 2008
    ..Thus, TGF-beta signaling controls the size of a specific brain area, the dorsal midbrain, by antagonizing canonical Wnt signaling and negatively regulating self-renewal of neuroepithelial stem cells...
  47. pmc TGF-beta utilizes SMAD3 to inhibit CD16-mediated IFN-gamma production and antibody-dependent cellular cytotoxicity in human NK cells
    Rossana Trotta
    Department of Molecular Virology, Immunology, and Medical Genetics, Ohio State University, Columbus, OH 43210, USA
    J Immunol 181:3784-92. 2008
    ..TGF-beta treatment induced SMAD3 phosphorylation, and ectopic overexpression of SMAD3 resulted in a significant decrease in IFN-gamma gene ..
  48. pmc Bacterial infection of Smad3/Rag2 double-null mice with transforming growth factor-beta dysregulation as a model for studying inflammation-associated colon cancer
    Lillian Maggio-Price
    Department of Comparative Medicine, University of Washington, School of Medicine, Seattle, Washington 98195, USA
    Am J Pathol 174:317-29. 2009
    ..Similarly, mice deficient in the transforming growth factor-beta signaling molecule, Smad3, develop colon cancer, but only after a bacterial trigger occurs, resulting in chronic inflammation...
  49. pmc Graded Smad2/3 activation is converted directly into levels of target gene expression in embryonic stem cells
    Marcela Guzman-Ayala
    Mammalian Neurogenesis, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London, United Kingdom
    PLoS ONE 4:e4268. 2009
    ..The concentration of the morphogen is critical for fate decisions in the responding cells. Smad2 and Smad3 are effectors of the Nodal/Activin branch of TGFbeta signalling: they are activated by receptors, enter the ..
  50. doi Smad3 loss confers resistance to the development of trinitrobenzene sulfonic acid-induced colorectal fibrosis
    G Latella
    University of L Aquila, L Aquila, Italy
    Eur J Clin Invest 39:145-56. 2009
    Transforming growth factor-beta (TGF-beta)/Smad3 signalling plays a central role in tissue fibrogenesis, acting as a potent stimulus of extracellular matrix (ECM) protein accumulation...
  51. pmc Transforming growth factor-{beta}-inducible phosphorylation of Smad3
    Guannan Wang
    Center for Advanced Biotechnology and Medicine
    J Biol Chem 284:9663-73. 2009
    ..Upon TGF-beta treatment, the highly homologous Smad2 and Smad3 are phosphorylated by the TGF-beta receptor at the SSXS motif in the C-terminal tail...
  52. pmc Transforming growth factor-beta/Smad3 signaling regulates insulin gene transcription and pancreatic islet beta-cell function
    Huei Min Lin
    Diabetes Branch, NIDDK, National Institutes of Health, Bethesda, MD 20892, USA
    J Biol Chem 284:12246-57. 2009
    ..We identify insulin as a TGF-beta target gene and show that the TGF-beta signaling effector Smad3 occupies the insulin gene promoter and represses insulin gene transcription...
  53. doi Smad2 and 3 transcription factors control muscle mass in adulthood
    Roberta Sartori
    Venetian Institute of Molecular Medicine, 35129 Padova, Italy
    Am J Physiol Cell Physiol 296:C1248-57. 2009
    ..Smad2 and Smad3 are the transcription factors downstream of myostatin/TGF-beta and induce an atrophy program that is muscle RING-..
  54. pmc Focal adhesion kinase is required for neural crest cell morphogenesis during mouse cardiovascular development
    Ainara Vallejo-Illarramendi
    Department of Physiology, UCSF, San Francisco, California 94158 2611, USA
    J Clin Invest 119:2218-30. 2009
    ..Our results indicate that FAK plays an essential role in cardiac outflow tract development by promoting the activation of molecules such as Crkl and Erk1/2...
  55. pmc TbetaRI independently activates Smad- and CD2AP-dependent pathways in podocytes
    Sandhya Xavier
    Division of Nephrology, Department of Medicine, Charles R Bronfman Institute for Personalized Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Am Soc Nephrol 20:2127-37. 2009
    ..TGF-beta promotes proapoptotic signaling mediated by Smad3 but also activates prosurvival pathways such as phosphoinositide-3 kinase (PI3K)/AKT; the latter requires the CD2-..
  56. pmc Retinoic acid can enhance conversion of naive into regulatory T cells independently of secreted cytokines
    Jens Nolting
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 206:2131-9. 2009
    ..The latter effect depended on the RA receptor alpha (RAR alpha) but did not require Smad3, despite the fact that RA enhanced Smad3 expression...
  57. pmc Ubiquitin ligase Nedd4L targets activated Smad2/3 to limit TGF-beta signaling
    Sheng Gao
    Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Mol Cell 36:457-68. 2009
    TGF-beta induces phosphorylation of the transcription factors Smad2 and Smad3 at the C terminus as well as at an interdomain linker region...
  58. pmc Structure of Smad1 MH1/DNA complex reveals distinctive rearrangements of BMP and TGF-beta effectors
    Nithya Baburajendran
    Laboratory of Structural Biochemistry, Genome Institute of Singapore, 60 Biopolis Street, Singapore
    Nucleic Acids Res 38:3477-88. 2010
    ..On the contrary, the TGF-beta-activated Smad3 triggers strikingly different programs such as mesodermal differentiation in early development...
  59. doi Smad3 deficiency reduces neurogenesis in adult mice
    Yu Wang
    Department of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    J Mol Neurosci 41:383-96. 2010
    Transforming growth factor-beta signaling through Smad3 inhibits cell proliferation in many cell types...
  60. doi Smad3 mediates cardiac inflammation and fibrosis in angiotensin II-induced hypertensive cardiac remodeling
    Xiao R Huang
    Department of Medicine and Therapeutics and Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong, Shatin, NT, Hong Kong
    Hypertension 55:1165-71. 2010
    Although Smad3 is a key mediator of fibrosis, the functional role of Smad3 in hypertensive cardiovascular disease remains unclear...
  61. doi Smad2 and Smad3 are redundantly essential for the TGF-beta-mediated regulation of regulatory T plasticity and Th1 development
    Tomohito Takimoto
    Department of Microbiology and Immunology, Keio University School of Medicine, Shinjyuku ku, Tokyo, Japan
    J Immunol 185:842-55. 2010
    ..TGF-beta plays a pivotal role in immune regulation, the roles of its downstream transcription factors, Smad2 and Smad3, have not been fully clarified...
  62. pmc c-Jun N-terminal kinase 1 promotes transforming growth factor-β1-induced epithelial-to-mesenchymal transition via control of linker phosphorylation and transcriptional activity of Smad3
    Jos L J van der Velden
    Department of Pathology, Health Sciences Research Facility, University of Vermont, Burlington, VT 05405, USA
    Am J Respir Cell Mol Biol 44:571-81. 2011
    ..via Smad complexes, the goal of the present study was to determine the impact of JNK1 on phosphorylation of Smad3 and Smad3-dependent transcriptional responses in lung epithelial cells...
  63. pmc Smad2 protects against TGF-beta/Smad3-mediated renal fibrosis
    Xiao ming Meng
    Department of Medicine and Therapeutics and Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong, Hong Kong Special Administrative Region, China
    J Am Soc Nephrol 21:1477-87. 2010
    Smad2 and Smad3 interact and mediate TGF-beta signaling. Although Smad3 promotes fibrosis, the role of Smad2 in fibrogenesis is largely unknown...
  64. pmc Smad3-dependent signaling underlies the TGF-β1-mediated enhancement in astrocytic iNOS expression
    Mary E Hamby
    Department of Neuroscience, University of Connecticut Health Center, Farmington, Connecticut, 06030, USA
    Glia 58:1282-91. 2010
    ..Consistent with ALK5 signaling, Smad3 accumulated in the nucleus of astrocytes as early as 30 min after TGF-beta1 (3 ng/mL) treatment and persisted upto ..
  65. pmc Blockade of endothelial-mesenchymal transition by a Smad3 inhibitor delays the early development of streptozotocin-induced diabetic nephropathy
    Jinhua Li
    Department of Anatomy and Developmental Biology, Monash University, Victoria, Australia
    Diabetes 59:2612-24. 2010
    ..In the present study, we hypothesized that blocking EndoMT reduces the early development of diabetic nephropathy...
  66. pmc Positive and negative transcriptional regulation of the Foxp3 gene is mediated by access and binding of the Smad3 protein to enhancer I
    Lili Xu
    Mucosal Immunity Section, Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 33:313-25. 2010
    ..IL-27 were here shown to be related processes involving modifications of baseline (TGF-β-induced) phosphorylated Smad3 (pSmad3) binding to a conserved enhancer region (enhancer I)...
  67. pmc Smad3 signaling is required for satellite cell function and myogenic differentiation of myoblasts
    Xiaojia Ge
    School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore
    Cell Res 21:1591-604. 2011
    ..Both growth factors have been shown to signal through a Smad3-dependent pathway. However to date, the role of Smad3 in muscle growth and differentiation is not investigated...
  68. doi Myostatin induces degradation of sarcomeric proteins through a Smad3 signaling mechanism during skeletal muscle wasting
    Sudarsanareddy Lokireddy
    School of Biological Sciences, Nanyang Technological University, Singapore
    Mol Endocrinol 25:1936-49. 2011
    ..In this report, we have demonstrated that myostatin signals through Smad3 (mothers against decapentaplegic homolog 3) to activate forkhead box O1 and Atrogin-1 expression, which further promotes the ubiquitination ..
  69. pmc Dopamine and α-synuclein dysfunction in Smad3 null mice
    Silvia Tapia-González
    Departamento de Neurobiología Investigación, Hospital Ramon y Cajal, IRYCIS, Madrid, Spain
    Mol Neurodegener 6:72. 2011
    ..We have examined the mesostriatal system in adult mice deficient in Smad3, a molecule involved in the intracellular TGF-β1 signalling cascade.
  70. doi Smad3 mediates ANG II-induced hypertensive kidney disease in mice
    Zhen Liu
    Department of Medicine and Therapeutics, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, China
    Am J Physiol Renal Physiol 302:F986-97. 2012
    Although Smad3 is a key mediator for fibrosis, its functional role and mechanisms in hypertensive nephropathy remain largely unclear...
  71. ncbi Abnormal mouse lung alveolarization caused by Smad3 deficiency is a developmental antecedent of centrilobular emphysema
    Hui Chen
    Center for Craniofacial Molecular Biology, University of Southern California, Los Angeles, CA, USA
    Am J Physiol Lung Cell Mol Physiol 288:L683-91. 2005
    ..b>Smad3 is a major downstream signal transducer in the TGF-beta pathway from the cell membrane to the nucleus...
  72. pmc FAST-2 is a mammalian winged-helix protein which mediates transforming growth factor beta signals
    B Liu
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Mol Cell Biol 19:424-30. 1999
    ..We have also examined the structure of the FAST-2 gene and find that it overlaps with a kinesin motor protein gene. The genes are transcribed in opposite orientations, and their transcripts overlap in the 3' untranslated region...
  73. ncbi Activations of ERK1/2 and JNK by transforming growth factor beta negatively regulate Smad3-induced alkaline phosphatase activity and mineralization in mouse osteoblastic cells
    Hideaki Sowa
    Division of Endocrinology Metabolism, Neurology and Hematology Oncology, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, 7 5 2 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    J Biol Chem 277:36024-31. 2002
    ..We recently demonstrated that Smad3, a TGF-beta signaling molecule, promotes ALP activity and mineralization in MC3T3-E1 cells...
  74. ncbi Distinct effects of TGF-beta 1 on CD4+ and CD8+ T cell survival, division, and IL-2 production: a role for T cell intrinsic Smad3
    Susan C McKarns
    Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 174:2071-83. 2005
    TGF-beta1 is critical for maintaining T cell homeostasis. Smad3 has been implicated in this regulatory process, yet the cellular targets and molecular details remain poorly understood...
  75. ncbi Oocyte-secreted factor activation of SMAD 2/3 signaling enables initiation of mouse cumulus cell expansion
    Rebecca A Dragovic
    Research Centre for Reproductive Health, Discipline of Obstetrics and Gynaecology, Medical School, University of Adelaide, Adelaide, South Australia 5005, Australia
    Biol Reprod 76:848-57. 2007
    ..This study provides evidence that the CEEF is composed of TGFB superfamily molecules that signal through SMAD 2/3 to enable the initiation of mouse cumulus expansion...
  76. doi TGFbeta mediates activation of transglutaminase 2 in response to oxidative stress that leads to protein aggregation
    Dong Myung Shin
    Department of Biochemistry and Molecular Biology AARC, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul 110 799, Korea
    FASEB J 22:2498-507. 2008
    ..stress trigger the release of TGFbeta, which subsequently activates TGase2 through the nuclear translocation of Smad3. Analysis of substrate proteins reveals that TGase2-mediated protein modification results in a decrease of protein ..
  77. ncbi Promoter analysis reveals critical roles for SMAD-3 and ATF-2 in expression of IL-23 p19 in macrophages
    Fahd Al-Salleeh
    Department of Oral Biology and Nebraska Center for Virology, University of Nebraska Medical Center, Lincoln, NE 68583, USA
    J Immunol 181:4523-33. 2008
    ..Inhibition of the JNK, but also the ERK MAPK pathways decreased expression of p19. These results suggest that ATF-2 and SMAD-3 are transcription factors, which are, in addition to NF-kappaB, essential for IL-23 p19 expression...
  78. pmc Pin1 protein regulates Smad protein signaling and pulmonary fibrosis
    Zhong Jian Shen
    Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53706, USA
    J Biol Chem 287:23294-305. 2012
    ..Pin1 was required for TGF-β-induced phosphorylation, nuclear translocation, and transcriptional activity of Smad3. In Pin1(-/-) cells, inhibitory Smad6 was found in the cytoplasm rather than nucleus...
  79. doi Maternal Smad3 deficiency compromises decidualization in mice
    Kun Qing Zhao
    State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China
    J Cell Biochem 113:3266-75. 2012
    ..Smad2 and Smad3 are receptor-regulated Smads (R-Smads) that transduce extracellular TGF-β/activin/Nodal signaling...
  80. doi TGF-beta-1 up-regulates extra-cellular matrix production in mouse hepatoblasts
    Daisuke Sugiyama
    Division of Hematopoietic Stem Cells, Advanced Medical Initiatives, Department of Advanced Medical Initiatives, Kyushu University Faculty of Medical Sciences, Fukuoka 812 8582, Japan
    Mech Dev 130:195-206. 2013
    ..Taken together, our observations suggest that hepatoblasts predominantly produce ECM factors under control of TGF-beta-1 in fetal liver...
  81. doi The loss of Trps1 suppresses ureteric bud branching because of the activation of TGF-β signaling
    Ting Gui
    Department of Pathology, School of Medicine, Shandong University, Jinan Wen Hua Xi Road 44, Jinan 250012, PR China
    Dev Biol 377:415-27. 2013
    ..WT and KO embryos, we found aberrant expression of genes associated with the transforming growth factor (TGF)-β/Smad3 signaling pathway in the KO UBs...
  82. pmc Smad signaling pathways regulate pancreatic endocrine development
    Yousef El-Gohary
    Department of Surgery, Division of Pediatric Surgery, Children s Hospital of Pittsburgh, One Children s Hospital Drive, 4401 Penn Ave, Pittsburgh, PA 15224, USA
    Dev Biol 378:83-93. 2013
    ..Specifically, the intracellular mediators of TGF-β signaling, smad2 and smad3, along with their inhibitor smad7, appear to mediate this process...
  83. ncbi Abrogation of Smad3 and Smad2 or of Smad4 gene expression positively regulates murine embryonic lung branching morphogenesis in culture
    J Zhao
    Department of Surgery, Children s Hospital Los Angeles Research Institute, University of Southern California Schools of Dentistry and Medicine, Los Angeles 90033, USA
    Dev Biol 194:182-95. 1998
    ..Antisense oligodeoxynucleotides were designed to attenuate Smad3 and Smad2 gene expression in embryonic (E11) mouse lungs over 4 days in culture...
  84. ncbi Genetic events and the role of TGF beta in epithelial tumour progression
    R J Akhurst
    Onyx Pharmaceuticals, Richmond, CA 94806, USA
    J Pathol 187:82-90. 1999
    ..It is this latter effect which may be clinically more significant, since many human tumours overexpress TGF beta, yet the majority still retain the intracellular signaling systems necessary for the cell to respond to this growth factor...
  85. ncbi Loss of Smad3 modulates wound healing
    G S Ashcroft
    Laboratory of Cell Regulation and Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Cytokine Growth Factor Rev 11:125-31. 2000
    ..Both Smad3 and its closely related homolog Smad2 act as latent nuclear transcriptional activators and mediate intracellular ..
  86. pmc Lack of a role for transforming growth factor-beta in cytotoxic T lymphocyte antigen-4-mediated inhibition of T cell activation
    T J Sullivan
    Howard Hughes Medical Institute, Cancer Research Laboratory, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 98:2587-92. 2001
    ..Also, CTLA-4 ligation equally inhibits proliferation of wild-type, TGF-beta1(-/-), and Smad3(-/-) T cells...
  87. ncbi The loss of Smad3 results in a lower rate of bone formation and osteopenia through dysregulation of osteoblast differentiation and apoptosis
    A J Borton
    Department of Pharmacology and Cancer Biology, Duke University, Durham, North Carolina 27708, USA
    J Bone Miner Res 16:1754-64. 2001
    b>Smad3 is a well-characterized intracellular effector of the transforming growth factor beta (TGF-beta) signaling pathway and was implicated recently in the potentiation of vitamin D receptor (VDR)-mediated signaling...
  88. ncbi Dynamic regulation of Smad expression during mesenchyme to epithelium transition in the metanephric kidney
    Leif Oxburgh
    Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
    Mech Dev 112:207-11. 2002
    ..Down-regulation is complete in lithium chloride induced mesenchymal condensates, indicating that Smad regulation takes place at an early stage, prior to mesenchyme to epithelium transition...
  89. ncbi Receptor-regulated and inhibitory Smads are critical in regulating transforming growth factor beta-mediated Meckel's cartilage development
    Yoshihiro Ito
    Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, 2250 Alcazar Street, Los Angeles, CA 90033, USA
    Dev Dyn 224:69-78. 2002
    ..The effectiveness of TGF-beta signaling is highly sensitive to the level of Smad gene expression...
  90. ncbi Identification of three novel Smad binding proteins involved in cell polarity
    Dennis R Warner
    University of Louisville Birth Defects Center, Department of Molecular, Cellular, and Craniofacial Biology, University of Louisville School of Dentistry, 501 South Preston Street, Suite 301, Louisville, KY 40292, USA
    FEBS Lett 539:167-73. 2003
    A yeast two-hybrid screen was utilized to identify novel Smad 3 binding proteins expressed in developing mouse orofacial tissue...
  91. ncbi Divergence of epidermal growth factor - transforming growth factor beta signaling in embryonic orofacial tissue
    Vasker Bhattacherjee
    University of Louisville Birth Defects Center, Department of Molecular, Cellular and Craniofacial Biology, University of Louisville School of Dentistry, Louisville, Kentucky 40292, USA
    In Vitro Cell Dev Biol Anim 39:257-61. 2003
    ..of embryonic maxillary mesenchymal cells revealed that TGFbeta-induced nuclear translocation of Smad 2 and Smad 3 proteins was not affected by EGF...
  92. ncbi Interaction of Smads with collagen types I, III, and V
    Leslie R Ellis
    Department of Molecular, Cellular, and Craniofacial Biology, ULSD, University of Louisville Birth Defects Center, Louisville, KY 40292, USA
    Biochem Biophys Res Commun 310:1117-23. 2003
    ..we have identified three types of collagens (types I, III, and V) that are capable of binding to the MH2 domain of Smad 3. These interactions were confirmed by glutathione S-transferase (GST) pull-down assays in which the MH2 domain of ..
  93. ncbi Essential role for Smad3 in regulating MCP-1 expression and vascular inflammation
    Mark W Feinberg
    Division of Cardiovascular Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Circ Res 94:601-8. 2004
    ..definitive evidence that the ability of TGF-beta(1) to inhibit MCP-1 expression is mediated via its effector Smad3. Adenoviral overexpression of Smad3 potently repressed inducible expression of endogenous MCP-1...
  94. pmc Induction of vascular smooth muscle alpha-actin gene transcription in transforming growth factor beta1-activated myofibroblasts mediated by dynamic interplay between the Pur repressor proteins and Sp1/Smad coactivators
    Sukanya V Subramanian
    Department of Physiology and Cell Biology, Dorothy M Davis Heart and Lung Research Institute, College of Medicine and Public Health, The Ohio State University, Columbus, OH 43210, USA
    Mol Biol Cell 15:4532-43. 2004
    ..Interplay between Pur repressor isoforms and Sp1 and Smad coactivators may regulate SMA enhancer output in TGFbeta1-activated myofibroblasts during episodes of wound repair and tissue remodeling...
  95. ncbi Loss of Smad3 in acute T-cell lymphoblastic leukemia
    Lawrence A Wolfraim
    Laboratory of Cell Regulation and Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    N Engl J Med 351:552-9. 2004
    ..The role of one of these intermediates--Smad3--in the pathogenesis of lymphoid neoplasia is unknown.
  96. ncbi Inhibins are the major activin ligands expressed during early thymocyte development
    Paula Licona
    Departamento de Inmunologia, Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico, Circuito Escolar s n, Mexico DF 04510
    Dev Dyn 235:1124-32. 2006
    ..Our data indicate that Activin/Inhibin signaling could regulate the process of thymus organogenesis and early thymocyte differentiation, as it has been demonstrated for other members of the TGF-beta superfamily...
  97. ncbi Reduced irradiation pulmonary fibrosis and stromal cell migration in Smad3-/- marrow chimeric mice
    Michael W Epperly
    Department of Radiation Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA
    In Vivo 20:573-82. 2006
    ..b>Smad3-/- mice display decreased ionizing irradiation-induced skin fibrosis, defective osteochondrogenesis and other ..
  98. ncbi Localization of TGF-beta signaling intermediates Smad2, 3, 4, and 7 in developing and mature human and mouse kidney
    Miriam C Banas
    Klinik und Poliklinik fur Innere Medizin II, Franz Josef Strauss Allee 11, 93053 Regensburg, Germany
    J Histochem Cytochem 55:275-85. 2007
    ..We studied the expression of TGF-beta-receptor activated Smads (Smad2 and Smad3), the common partner Smad (Smad4), an inhibitory Smad (Smad7), and the activated (phosphorylated) Smad2 (pSmad2) ..
  99. pmc The anaphase-promoting complex coordinates initiation of lens differentiation
    George Wu
    University of Pittsburgh Cancer Institute, Pittsburgh, PA 15312, USA
    Mol Biol Cell 18:1018-29. 2007
    ..Thus, Cdh1/APC is crucial to the coordination of cell cycle progression and the initiation of lens differentiation through mediating TGF-beta-signaling-induced destruction of SnoN...
  100. pmc Filamin B represses chondrocyte hypertrophy in a Runx2/Smad3-dependent manner
    Lihua Zheng
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    J Cell Biol 178:121-8. 2007
    ..Filamin B binds Smad3, which is known to interact with Runx2. Smad3 phosphorylation is increased in the mutant mice...
  101. doi Transgelin is a direct target of TGF-beta/Smad3-dependent epithelial cell migration in lung fibrosis
    Haiying Yu
    University of Giessen Lung Center, Department of Medicine II, Justus Liebig University Giessen, D 35392 Giessen, Germany
    FASEB J 22:1778-89. 2008
    ..Here, we identified the transgelin (tagln) gene as a novel immediate target of TGF-beta/Smad3-dependent gene expression in ATII cells using a Smad3 chromatin immunoprecipitation (ChIP) screen...

Research Grants12

  1. IMMUNOBIOLOGY AND GENETICS OF WOUND HEALING REGENERATION
    Ellen Heber Katz; Fiscal Year: 2001
    ....
  2. MECHANISMS OF BIOENGINEERED SKIN IN HUMAN WOUNDS
    Vincent Falanga; Fiscal Year: 2003
    ..The proposed studies will advance our understanding of how a bioengineered skin product works in a human chronic wound and provide insight into further bioengineering needs. ..
  3. Mechanisms of TGFbeta-mediated fibroblastic transition
    Andrei Bakin; Fiscal Year: 2006
    ..The proposed research will help to define the TGFbeta signaling network and will facilitate the design of novel selective inhibition of TGFbeta's tumor promoting activity. ..
  4. Identification of extrinsic signals in blood formation
    Jan Christian; Fiscal Year: 2006
    ..Understanding how normal blood development occurs is crucial to understanding and preventing disease resulting from misregulation of these pathways. ..
  5. KLF4, TGF-b1, and transplantation arteriosclerosis
    Mark W Feinberg; Fiscal Year: 2010
    ..The results of these studies are of considerable scientific interest and may serve as the basis for novel therapeutic strategies to modulate TAA and the macrophage response to cytokine stimulation. ..
  6. PATHOGENIC MECHANISMS OF VENOUS DISEASE
    Vincent Falanga; Fiscal Year: 2004
    ..The proposed studies should advance knowledge of the pathogenesis of venous ulceration and fibrosis. ..
  7. Fucosylated cell surface molecules in tumor invasion
    STEVEN DOMINO; Fiscal Year: 2005
    ..tumors in mice carrying germline inactivating mutations in the transforming growth factor-beta signaling gene Smad3. 3) To test the importance of alpha(1,2)fucosylated oligosaccharides in colon cancer in vivo by determining the ..
  8. Inhibition of Macrophage Activation by Smad3
    Mark Feinberg; Fiscal Year: 2005
    ..We found that a single member of the Smad family. Smad3-is critical for inhibiting markers of macrophage activation...
  9. Control of Hox gene expression and neuronal identity
    Jeh Ping Liu; Fiscal Year: 2007
    ....
  10. Tissue Engineering for the Treatment of Delayed Healing
    Vincent Falanga; Fiscal Year: 2007
    ..These studies will advance our understanding of how to reconstitute the wound bed and whether it is possible to correct the abnormal cellular phenotype in non-healing wounds. ..
  11. Analysis of BMP-4 activity in Cleavage mutant mice
    Jan Christian; Fiscal Year: 2007
    ..Understanding the molecular mechanisms by which BMP activity is regulated is key to understanding, treating and preventing congenital anomalies and diseases. [unreadable] [unreadable]..
  12. Mapping Murine Regeneation Genes
    ELLEN S HEBER KATZ; Fiscal Year: 2009
    ..Our study of regenerative healing using the well-defined LGXSM mouse resource enables us to realize the promising potential of this genetically powerful and unique healing model system. ..