Slc39a8

Summary

Gene Symbol: Slc39a8
Description: solute carrier family 39 (metal ion transporter), member 8
Alias: 4933419D20Rik, AA986696, BIGM103, ZIP-8, Zip8, zinc transporter ZIP8, Zrt- and Irt-like protein 8
Species: mouse

Top Publications

  1. ncbi ZIP8, member of the solute-carrier-39 (SLC39) metal-transporter family: characterization of transporter properties
    Lei He
    Department of Environmental Health, University of Cincinnati Medical Center, P O Box 670056, Cincinnati, OH 45267 0056, USA
    Mol Pharmacol 70:171-80. 2006
  2. pmc Generation of a Slc39a8 hypomorph mouse: markedly decreased ZIP8 Zn²⁺/(HCO₃⁻)₂ transporter expression
    Bin Wang
    Department of Environmental Health and Center for Environmental Genetics, University of Cincinnati Medical Center, Cincinnati, OH 45267 0056, USA
    Biochem Biophys Res Commun 410:289-94. 2011
  3. pmc Cd2+ versus Zn2+ uptake by the ZIP8 HCO3--dependent symporter: kinetics, electrogenicity and trafficking
    Zhiwei Liu
    Department of Environmental Health and Center for Environmental Genetics CEG, University of Cincinnati Medical Center, P O Box 670056, Cincinnati, OH 45267 0056, USA
    Biochem Biophys Res Commun 365:814-20. 2008
  4. ncbi Identification of molecular markers that are expressed in discrete anterior-posterior domains of the endoderm from the gastrula stage to mid-gestation
    Billie A Moore-Scott
    Division of Developmental Biology, Cincinnati Children s Hospital Research Foundation, University of Cincinnati, Cincinnati, Ohio 45229 3039, USA
    Dev Dyn 236:1997-2003. 2007
  5. ncbi Enhanced cadmium-induced testicular necrosis and renal proximal tubule damage caused by gene-dose increase in a Slc39a8-transgenic mouse line
    Bin Wang
    Department of Environmental Health, and The Center for Environmental Genetics CEG, University Cincinnati Medical Center, Cincinnati, OH 45267 0056, USA
    Am J Physiol Cell Physiol 292:C1523-35. 2007
  6. pmc Identification of mouse SLC39A8 as the transporter responsible for cadmium-induced toxicity in the testis
    Timothy P Dalton
    Department of Environmental Health and the Center for Environmental Genetics, University of Cincinnati Medical Center, Cincinnati, OH 45267 0056, USA
    Proc Natl Acad Sci U S A 102:3401-6. 2005
  7. doi Parathyroid hormone regulates fetal-placental mineral homeostasis
    Charlene S Simmonds
    Faculty of Medicine, Memorial University of Newfoundland, St John s, Newfoundland, Canada
    J Bone Miner Res 25:594-605. 2010
  8. doi Oral cadmium in mice carrying 5 versus 2 copies of the Slc39a8 gene: comparison of uptake, distribution, metal content, and toxicity
    Scott N Schneider
    Department of Environmental Health and Center for Environmental Genetics, University of Cincinnati Medical Center, Cincinnati, OH, USA Email
    Int J Toxicol 33:14-20. 2014
  9. doi Regulation of the catabolic cascade in osteoarthritis by the zinc-ZIP8-MTF1 axis
    Jin Hong Kim
    Cell Dynamics Research Center and School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 500 712, Korea
    Cell 156:730-43. 2014
  10. doi Reciprocal activation of hypoxia-inducible factor (HIF)-2α and the zinc-ZIP8-MTF1 axis amplifies catabolic signaling in osteoarthritis
    M Lee
    School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 500 712, Republic of Korea
    Osteoarthritis Cartilage 24:134-45. 2016

Research Grants

  1. GENOTOXICITY IN CYP1A2 DEFICIENT TRANSGENIC MICE
    Daniel Nebert; Fiscal Year: 2002
  2. CYP1A1 GENE AND ENVIRONMENTAL TOXICITY
    Daniel Nebert; Fiscal Year: 2005
  3. PAHs: Balance of Detoxication vs Metabolic Activation
    Daniel Nebert; Fiscal Year: 2009
  4. Molecular Genetics of Cadmium Toxicity
    Daniel W Nebert; Fiscal Year: 2010

Scientific Experts

  • D W Nebert
  • T Kambe
  • Bin Wang
  • Lei He
  • Timothy P Dalton
  • Manoocher Soleimani
  • Kuppuswami Girijashanker
  • Hitomi Fujishiro
  • Zhiwei Liu
  • Marian L Miller
  • Scott N Schneider
  • Akihiro Koike
  • M Lee
  • Hong Li
  • Jin Hong Kim
  • Supak Jenkitkasemwong
  • Marina Galvez-Peralta
  • Seiichiro Himeno
  • Charlene S Simmonds
  • Moon Suhn Ryu
  • Jodie M Reed
  • Billie A Moore-Scott
  • Jodi Dufner-Beattie
  • Keith F Stringer
  • Akihiro Ohishi
  • Kazuki Nagasawa
  • J H Kim
  • Kentaro Nishida
  • J S Chun
  • Y Shin
  • Jyakusho Sou
  • Y Won
  • Churl Hong Chun
  • Gyuseok Lee
  • Ji Sun Kwak
  • Minhee Shin
  • Jang Soo Chun
  • Je Hwang Ryu
  • Jimin Jeon
  • Minju Lee
  • Scott E Afton
  • Jinseol Rhee
  • Yoonkyung Won
  • Mitchell D Knutson
  • Bryan L Eppert
  • Scott Afton
  • Yu Yano
  • Chia Yu Wang
  • Bryan Mackenzie
  • Maya Tanihara
  • Lucia F Jorge-Nebert
  • Yukina Takada
  • Hongbin Dong
  • Christopher S Kovacs
  • Gerard Karsenty
  • Andrew C Karaplis
  • Saori Yasumitsu
  • Shuichi Enomoto
  • Satomi Okugaki
  • Louis A Lichten
  • Robert J Cousins
  • Juan P Liuzzi
  • Nadine Dragin
  • James M Wells
  • Douglas D Richardson
  • Jennifer J Kordich
  • Suh Chin J Lin
  • Robert Opoka
  • Jodie Reed
  • Glen K Andrews
  • Zhixin L Huang
  • Jim Geiser
  • Wenhao Xu
  • Xiaoqing Chang
  • C Stuart Baxter
  • Li Jin

Detail Information

Publications20

  1. ncbi ZIP8, member of the solute-carrier-39 (SLC39) metal-transporter family: characterization of transporter properties
    Lei He
    Department of Environmental Health, University of Cincinnati Medical Center, P O Box 670056, Cincinnati, OH 45267 0056, USA
    Mol Pharmacol 70:171-80. 2006
    ..Members of our laboratory recently identified the ZIP8 transporter protein, encoded by the mouse Slc39a8 gene, to be responsible for genetic differences in response to cadmium damage of the testis...
  2. pmc Generation of a Slc39a8 hypomorph mouse: markedly decreased ZIP8 Zn²⁺/(HCO₃⁻)₂ transporter expression
    Bin Wang
    Department of Environmental Health and Center for Environmental Genetics, University of Cincinnati Medical Center, Cincinnati, OH 45267 0056, USA
    Biochem Biophys Res Commun 410:289-94. 2011
    Previously this laboratory has identified the mouse Slc39a8 gene encoding the ZIP8 transporter, important in cadmium uptake. ZIP8 functions endogenously as a electroneutral Zn(2+)/(HCO(3)(-))(2) symporter, moving both ions into the cell...
  3. pmc Cd2+ versus Zn2+ uptake by the ZIP8 HCO3--dependent symporter: kinetics, electrogenicity and trafficking
    Zhiwei Liu
    Department of Environmental Health and Center for Environmental Genetics CEG, University of Cincinnati Medical Center, P O Box 670056, Cincinnati, OH 45267 0056, USA
    Biochem Biophys Res Commun 365:814-20. 2008
    The mouse Slc39a8 gene encodes the ZIP8 transporter, which has been shown to be a divalent cation/HCO3- symporter...
  4. ncbi Identification of molecular markers that are expressed in discrete anterior-posterior domains of the endoderm from the gastrula stage to mid-gestation
    Billie A Moore-Scott
    Division of Developmental Biology, Cincinnati Children s Hospital Research Foundation, University of Cincinnati, Cincinnati, Ohio 45229 3039, USA
    Dev Dyn 236:1997-2003. 2007
    ..We have identified three genes Slc39a8, Amot, and Dp1l1, which are expressed in the visceral endoderm at e7.5. Starting at e9...
  5. ncbi Enhanced cadmium-induced testicular necrosis and renal proximal tubule damage caused by gene-dose increase in a Slc39a8-transgenic mouse line
    Bin Wang
    Department of Environmental Health, and The Center for Environmental Genetics CEG, University Cincinnati Medical Center, Cincinnati, OH 45267 0056, USA
    Am J Physiol Cell Physiol 292:C1523-35. 2007
    ..Using positional cloning, we previously identified the Slc39a8 (encoding an apical-surface ZIP8 transporter protein) as the gene most likely responsible for the phenotype...
  6. pmc Identification of mouse SLC39A8 as the transporter responsible for cadmium-induced toxicity in the testis
    Timothy P Dalton
    Department of Environmental Health and the Center for Environmental Genetics, University of Cincinnati Medical Center, Cincinnati, OH 45267 0056, USA
    Proc Natl Acad Sci U S A 102:3401-6. 2005
    ..demonstrated a 400-kb haplotype block consistent with the Cd-induced toxicity phenotype; in this region is the Slc39a8 gene encoding a member of the solute-carrier superfamily...
  7. doi Parathyroid hormone regulates fetal-placental mineral homeostasis
    Charlene S Simmonds
    Faculty of Medicine, Memorial University of Newfoundland, St John s, Newfoundland, Canada
    J Bone Miner Res 25:594-605. 2010
    ..Although parathyroid hormone-related protein (PTHrP) acts in concert with PTH to regulate fetal mineral homeostasis and placental calcium transfer, unlike PTH, it does not upregulate in response to fetal hypocalcemia...
  8. doi Oral cadmium in mice carrying 5 versus 2 copies of the Slc39a8 gene: comparison of uptake, distribution, metal content, and toxicity
    Scott N Schneider
    Department of Environmental Health and Center for Environmental Genetics, University of Cincinnati Medical Center, Cincinnati, OH, USA Email
    Int J Toxicol 33:14-20. 2014
    The highly conserved human and mouse SLC39A8 gene encodes the divalent cation/bicarbonate symporter ZIP8 expressed ubiquitously in most cell types...
  9. doi Regulation of the catabolic cascade in osteoarthritis by the zinc-ZIP8-MTF1 axis
    Jin Hong Kim
    Cell Dynamics Research Center and School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 500 712, Korea
    Cell 156:730-43. 2014
    ..Among Zn2+ transporters, the Zn2+ importer ZIP8 was specifically upregulated in OA cartilage of humans and mice, resulting in increased levels of intracellular Zn2+..
  10. doi Reciprocal activation of hypoxia-inducible factor (HIF)-2α and the zinc-ZIP8-MTF1 axis amplifies catabolic signaling in osteoarthritis
    M Lee
    School of Life Sciences, Gwangju Institute of Science and Technology, Gwangju 500 712, Republic of Korea
    Osteoarthritis Cartilage 24:134-45. 2016
    Hypoxia-inducible factor (HIF)-2α and the zinc-ZIP8-MTF1 axis in chondrocytes serve as catabolic regulators of osteoarthritic cartilage destruction by regulating the expression of catabolic factor genes...
  11. doi Inhibitory effect of divalent metal cations on zinc uptake via mouse Zrt-/Irt-like protein 8 (ZIP8)
    Akihiro Koike
    Department of Environmental Biochemistry, Kyoto Pharmaceutical University, 5 Nakauchi cho, Misasagi, Yamashina ku, Kyoto 607 8414, Japan
    Life Sci . 2016
    There is controversy regarding the substrate specificity of ZIP8, a ZIP isoform, involved in regulation of extra- and intracellular zinc levels...
  12. pmc ZIP8 zinc transporter: indispensable role for both multiple-organ organogenesis and hematopoiesis in utero
    Marina Galvez-Peralta
    Department of Environmental Health, University of Cincinnati Medical Center, Cincinnati, Ohio, United States of America
    PLoS ONE 7:e36055. 2012
    Previously this laboratory characterized Slc39a8-encoded ZIP8 as a Zn(2+)/(HCO(3)(-))(2) symporter; yet, the overall physiological importance of ZIP8 at the whole-organism level remains unclear...
  13. pmc Physiologic implications of metal-ion transport by ZIP14 and ZIP8
    Supak Jenkitkasemwong
    Food Science and Human Nutrition Department, University of Florida, Gainesville, FL 32611, USA
    Biometals 25:643-55. 2012
    ..Two likely candidates are the recently identified transmembrane proteins ZIP14 and ZIP8, which have been shown to mediate the cellular uptake of a number of divalent metal ions including zinc, iron, ..
  14. doi Roles of ZIP8, ZIP14, and DMT1 in transport of cadmium and manganese in mouse kidney proximal tubule cells
    Hitomi Fujishiro
    Laboratory of Molecular Nutrition and Toxicology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima 770 8514, Japan
    Metallomics 4:700-8. 2012
    ..Zinc transporters such as Zrt, Irt-related protein 8 (ZIP8) and ZIP14, and divalent metal transporter 1 (DMT1) have been reported to have affinities for Cd(2+) and Mn(2+)...
  15. doi ZIP14 and ZIP8 zinc/bicarbonate symporters in Xenopus oocytes: characterization of metal uptake and inhibition
    Daniel W Nebert
    Department of Environmental Health and Center for Environmental Genetics CEG, University of Cincinnati Medical Center, Cincinnati, OH 45267 0056, USA
    Metallomics 4:1218-25. 2012
    The highly conserved human and mouse SLC39A14 and SLC39A8 genes encode the ZIP14 and ZIP8 transporters, respectively-functioning as divalent cation/bicarbonate symporters and expressed in dozens of tissues...
  16. ncbi Mouse ZIP1 and ZIP3 genes together are essential for adaptation to dietary zinc deficiency during pregnancy
    Jodi Dufner-Beattie
    Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Genesis 44:239-51. 2006
    ..In conclusion, mutations in the ZIP1 and ZIP3 zinc transporter genes are silent when dietary intake of zinc is normal, but can dramatically compromise the success of pregnancy when dietary intake of zinc is limiting...
  17. pmc Slc39a14 gene encodes ZIP14, a metal/bicarbonate symporter: similarities to the ZIP8 transporter
    Kuppuswami Girijashanker
    Department of Environmental Health, University of Cincinnati Medical Center, P O Box 670056, Cincinnati, OH 45267 0056, USA
    Mol Pharmacol 73:1413-23. 2008
    ..Viewed from an evolutionary perspective, SLC39A14 and SLC39A8 are the most closely related, each having three noncoding exons 1...
  18. pmc Zinc transporters ZnT1 (Slc30a1), Zip8 (Slc39a8), and Zip10 (Slc39a10) in mouse red blood cells are differentially regulated during erythroid development and by dietary zinc deficiency
    Moon Suhn Ryu
    Food Science and Human Nutrition Department, Center for Nutritional Sciences, University of Florida, Gainesville, FL 32611 0370, USA
    J Nutr 138:2076-83. 2008
    ..ZnT1, Zip8, and Zip10 were detected among the 12 transporter proteins tested...
  19. doi Involvement of DNA hypermethylation in down-regulation of the zinc transporter ZIP8 in cadmium-resistant metallothionein-null cells
    Hitomi Fujishiro
    Laboratory of Molecular Nutrition and Toxicology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro cho, Tokushima 770 8514, Japan
    Toxicol Appl Pharmacol 241:195-201. 2009
    The Zrt/Irt-related protein 8 (ZIP8) encoded by slc39a8 is now emerging as an important zinc transporter involved in cellular cadmium incorporation...
  20. ncbi An overview of a wide range of functions of ZnT and Zip zinc transporters in the secretory pathway
    Taiho Kambe
    Division of Integrated Life Science, Graduate School of Biostudies, Kyoto University, Kyoto, Japan
    Biosci Biotechnol Biochem 75:1036-43. 2011
    ..Recent questions concerning zinc released into the cytoplasm from the secretory pathway, which then functions as an intracellular signaling molecule, are also briefly reviewed, emphasizing zinc transporter functions...

Research Grants5

  1. GENOTOXICITY IN CYP1A2 DEFICIENT TRANSGENIC MICE
    Daniel Nebert; Fiscal Year: 2002
    ..S. population. ..
  2. CYP1A1 GENE AND ENVIRONMENTAL TOXICITY
    Daniel Nebert; Fiscal Year: 2005
    ..abstract_text> ..
  3. PAHs: Balance of Detoxication vs Metabolic Activation
    Daniel Nebert; Fiscal Year: 2009
    ..dissemination of ingested BaP and will be informative in clinical studies in which we would determine which haplotypes of these three human genes might be associated with resistance vs. sensitivity to PAH-induced toxicity and cancer. ..
  4. Molecular Genetics of Cadmium Toxicity
    Daniel W Nebert; Fiscal Year: 2010
    ..During the current funding period, we identified the Slc39a8 gene as the Cdm locus responsible for Cd-induced testicular necrosis...