Slc2a3

Summary

Gene Symbol: Slc2a3
Description: solute carrier family 2 (facilitated glucose transporter), member 3
Alias: AA408729, AL023014, AL024341, AU040424, C78366, Glut-3, Glut3, solute carrier family 2, facilitated glucose transporter member 3, glucose transporter type 3, brain
Species: mouse

Top Publications

  1. ncbi Lmx1b, Pet-1, and Nkx2.2 coordinately specify serotonergic neurotransmitter phenotype
    Leping Cheng
    The Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 23:9961-7. 2003
  2. ncbi Trans-activators regulating neuronal glucose transporter isoform-3 gene expression in mammalian neurons
    Augustine Rajakumar
    Division of Neonatology and Developmental Biology, Department of Pediatrics, David Geffen School of Medicine, UCLA, Los Angeles, California 90095 1752, USA
    J Biol Chem 279:26768-79. 2004
  3. ncbi Glucose transporter isoform-3 mutations cause early pregnancy loss and fetal growth restriction
    Amit Ganguly
    Division of Neonatology and Developmental Biology, Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    Am J Physiol Endocrinol Metab 292:E1241-55. 2007
  4. ncbi Developmental expression and cellular localization of glucose transporter molecules during mouse preimplantation development
    M Aghayan
    Department of Obstetrics and Gynecology, University of Pennsylvania Medical Center, Philadelphia 19104
    Development 115:305-12. 1992
  5. ncbi Developmental regulation of genes mediating murine brain glucose uptake
    J Y Khan
    Division of Neonatology and Developmental Biology, Department of Pediatrics, University of Pittsburgh, Magee Womens Research Institute, Pittsburgh, Pennsylvania 15213 3180, USA
    Am J Physiol 276:R892-900. 1999
  6. ncbi Glucose transporter gene expression in early mouse embryos
    A Hogan
    Department of Medical Biochemistry, University of Calgary Health Sciences Center, Alberta, Canada
    Development 113:363-72. 1991
  7. pmc Essential role of glucose transporter GLUT3 for post-implantation embryonic development
    S Schmidt
    Department of Pharmacology Toxicology, German Institute of Human Nutrition, Nuthetal, Germany
    J Endocrinol 200:23-33. 2009
  8. doi Neuronal functions, feeding behavior, and energy balance in Slc2a3+/- mice
    Stefan Schmidt
    Department of Pharmacology, German Institute of Human Nutrition Potsdam Rehbruecke, Nuthetal, Germany
    Am J Physiol Endocrinol Metab 295:E1084-94. 2008
  9. pmc Glucose transporter GLUT3: ontogeny, targeting, and role in the mouse blastocyst
    M Pantaleon
    Department of Physiology and Pharmacology, The University of Queensland, Brisbane, Australia
    Proc Natl Acad Sci U S A 94:3795-800. 1997
  10. doi Glucose transporter isoform-3-null heterozygous mutation causes sexually dimorphic adiposity with insulin resistance
    Amit Ganguly
    Division of Neonatology and Developmental Biology, Neonatal Research Center, Department of Pediatrics, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095 1752, USA
    Am J Physiol Endocrinol Metab 294:E1144-51. 2008

Research Grants

  1. Role of Placental Transport In Fetal Growth
    Sherin Devaskar; Fiscal Year: 2008
  2. POSTNATAL ASPECTS OF A GLUCOSE TRANSPORTER
    Sherin Devaskar; Fiscal Year: 2008
  3. PERINATAL METABOLIC AND HORMONAL EFFECTS
    Sherin U Devaskar; Fiscal Year: 2010

Scientific Experts

  • Anne Dupressoir
  • Karen L Kind
  • S J Vannucci
  • T Hahn
  • Sherin Devaskar
  • Charles A Stuart
  • Miguel Constancia
  • Tomohisa Kihira
  • Caitlin S Wyrwoll
  • Shanthie Thamotharan
  • Amit Ganguly
  • Bo Chul Shin
  • Daniela Sarahí Gutiérrez-Torres
  • Elisabeth E Mlynarski
  • Xiaojun Zha
  • Yongjun Chen
  • Jie Hao
  • Theodore Chauvin
  • Hiroko Ida-Yonemochi
  • Shang Ming Huang
  • Simon J Tunster
  • Y Zhao
  • Xing Hui Shen
  • S Schmidt
  • Patricia V Miranda
  • Hyung Gun Maeng
  • Preethi Vijayaraj
  • Nupur Raychaudhuri
  • Keiko Kawauchi
  • Stefan Schmidt
  • Jan Mulder
  • N G Copeland
  • Constanza Angulo
  • Jing Li
  • Bu Fang Ren
  • N A Jenkins
  • Yasunori Sakakura
  • Takashi Umekawa
  • Dilusha A William
  • S Nagamatsu
  • D J Gilbert
  • Augustine Rajakumar
  • Leping Cheng
  • Elizabeth Goldmuntz
  • Ernesto Ramos-Martínez
  • Bernice E Morrow
  • Zhenzhen Tu
  • Keguo Jiang
  • Michael Xie
  • Beverly S Emanuel
  • Karlene Coleman
  • Małgorzata Piotrowicz
  • Doron Gothelf
  • Fuquan Jin
  • Damian Heine-Suner
  • Hongbing Zhang
  • Carmen González-Horta
  • Ann Swillen
  • Elaine Zackai
  • Jacob Vorstman
  • Jeroen Breckpot
  • Koen Devriendt
  • Blanca Sánchez-Ramírez
  • Rocío Infante-Ramírez
  • Bruno Marino
  • Tamim H Shaikh
  • Wendy R Kates
  • Maria Cristina Digilio
  • Nicole Philip
  • Lijun Di
  • Silvia E Racedo
  • Xiaowu Gai
  • Anne S Bassett
  • Donna M McDonald-McGinn
  • Luz Maria Del Razo
  • Xianguo Chen
  • Chunjia Li
  • Tony J Simon
  • Bruno Dallapiccola
  • Carrie E Bearden
  • Stephan Eliez
  • Molly B Sheridan
  • Pan Zhao
  • Marcella Devoto
  • Amy E Roberts
  • Shuang Ji
  • Margarita Levario-Carrillo
  • Eva W C Chow
  • Haisheng Zhou
  • Tingwei Guo

Detail Information

Publications73

  1. ncbi Lmx1b, Pet-1, and Nkx2.2 coordinately specify serotonergic neurotransmitter phenotype
    Leping Cheng
    The Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 23:9961-7. 2003
    ..2, drives 5-HT differentiation in the dorsal spinal cord. Our studies therefore define a molecular pathway necessary and sufficient to specify the serotonergic neurotransmitter phenotype...
  2. ncbi Trans-activators regulating neuronal glucose transporter isoform-3 gene expression in mammalian neurons
    Augustine Rajakumar
    Division of Neonatology and Developmental Biology, Department of Pediatrics, David Geffen School of Medicine, UCLA, Los Angeles, California 90095 1752, USA
    J Biol Chem 279:26768-79. 2004
    ..By employing the primer extension assay, the transcription start site of the murine Glut 3 gene in the brain was localized to -305 bp 5' to the ATG translation start codon...
  3. ncbi Glucose transporter isoform-3 mutations cause early pregnancy loss and fetal growth restriction
    Amit Ganguly
    Division of Neonatology and Developmental Biology, Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    Am J Physiol Endocrinol Metab 292:E1241-55. 2007
    Glucose transporter isoform-3 (GLUT3) is the trophoblastic facilitative glucose transporter...
  4. ncbi Developmental expression and cellular localization of glucose transporter molecules during mouse preimplantation development
    M Aghayan
    Department of Obstetrics and Gynecology, University of Pennsylvania Medical Center, Philadelphia 19104
    Development 115:305-12. 1992
    ..This observation suggests a different functional significance for these isoforms during mouse preimplantation development...
  5. ncbi Developmental regulation of genes mediating murine brain glucose uptake
    J Y Khan
    Division of Neonatology and Developmental Biology, Department of Pediatrics, University of Pittsburgh, Magee Womens Research Institute, Pittsburgh, Pennsylvania 15213 3180, USA
    Am J Physiol 276:R892-900. 1999
    ....
  6. ncbi Glucose transporter gene expression in early mouse embryos
    A Hogan
    Department of Medical Biochemistry, University of Calgary Health Sciences Center, Alberta, Canada
    Development 113:363-72. 1991
    ..Genetic mapping studies of glucose transporters in the mouse show that Glut-1 is located on chromosome 4, Glut-2 on chromosome 3, Glut-3 on chromosome 6, and Glut-4 on chromosome 11...
  7. pmc Essential role of glucose transporter GLUT3 for post-implantation embryonic development
    S Schmidt
    Department of Pharmacology Toxicology, German Institute of Human Nutrition, Nuthetal, Germany
    J Endocrinol 200:23-33. 2009
    Deletion of glucose transporter gene Slc2a3 (GLUT3) has previously been reported to result in embryonic lethality. Here, we define the exact time point of growth arrest and subsequent death of the embryo...
  8. doi Neuronal functions, feeding behavior, and energy balance in Slc2a3+/- mice
    Stefan Schmidt
    Department of Pharmacology, German Institute of Human Nutrition Potsdam Rehbruecke, Nuthetal, Germany
    Am J Physiol Endocrinol Metab 295:E1084-94. 2008
    Homozygous deletion of the gene of the neuronal glucose transporter GLUT3 (Slc2a3) in mice results in embryonic lethality, whereas heterozygotes (Slc2a3+/-) are viable...
  9. pmc Glucose transporter GLUT3: ontogeny, targeting, and role in the mouse blastocyst
    M Pantaleon
    Department of Physiology and Pharmacology, The University of Queensland, Brisbane, Australia
    Proc Natl Acad Sci U S A 94:3795-800. 1997
    ..We identified and localized the primary transporter in TE cells. It is glucose transporter GLUT3, previously described in the mouse as neuron-specific...
  10. doi Glucose transporter isoform-3-null heterozygous mutation causes sexually dimorphic adiposity with insulin resistance
    Amit Ganguly
    Division of Neonatology and Developmental Biology, Neonatal Research Center, Department of Pediatrics, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095 1752, USA
    Am J Physiol Endocrinol Metab 294:E1144-51. 2008
    We examined male and female glucose transporter isoform-3 (GLUT3; placenta)-null heterozygous(+/-) mutation-carrying mice and compared them with age- and sex-matched wild-type(+/+) littermates...
  11. ncbi Glucose transporter expression in brain. cDNA sequence of mouse GLUT3, the brain facilitative glucose transporter isoform, and identification of sites of expression by in situ hybridization
    S Nagamatsu
    Department of Biochemistry and Molecular Biology, University of Chicago, Illinois 60637
    J Biol Chem 267:467-72. 1992
    Complementary DNAs encoding the mouse GLUT3/brain facilitative glucose transporter have been isolated and sequenced...
  12. pmc Neuronal glucose transporter isoform 3 deficient mice demonstrate features of autism spectrum disorders
    Y Zhao
    Division of Neonatology, Neonatal Research Center, David Geffen School of Medicine UCLA, Los Angeles, CA 90095, USA
    Mol Psychiatry 15:286-99. 2010
    ..This is the first description of GLUT3 deficiency that forms a possible novel genetic mechanism for pervasive developmental disorders, such as the ..
  13. pmc Prenatal Exposure to Sodium Arsenite Alters Placental Glucose 1, 3, and 4 Transporters in Balb/c Mice
    Daniela Sarahí Gutiérrez-Torres
    Programa de Maestría en Ciencias en Biotecnología, Facultad de Ciencias Quimicas, Universidad Autonoma de Chihuahua, Circuito No 1 Nuevo Campus Universitario, 31125 Chihuahua, Chih, Mexico
    Biomed Res Int 2015:175025. 2015
    ..The aim of this study was to analyze the effect of sodium arsenite (NaAsO2) exposure on GLUT1, GLUT3, and GLUT4 protein expression and on placental morphology...
  14. ncbi Identification of a murine TEF-1-related gene expressed after mitogenic stimulation of quiescent fibroblasts and during myogenic differentiation
    D K Hsu
    Department of Molecular Biology, Holland Laboratory, American Red Cross, Rockville, Maryland 20855, USA
    J Biol Chem 271:13786-95. 1996
    ..These results indicate that increased expression of a TEF-1-related protein may be important for both mitogen-stimulated fibroblast proliferation and skeletal muscle cell differentiation...
  15. ncbi Glucose utilization and glucose transporter proteins GLUT-1 and GLUT-3 in brains of diabetic (db/db) mice
    S J Vannucci
    Department of Pediatrics, Milton S Hershey Medical Center, Hershey, Pennsylvania 17033, USA
    Am J Physiol 272:E267-74. 1997
    ..The results of this study indicate that the db/db mouse has markedly decelerated brain growth accompanied by global reductions in glucose metabolism that are not due to reductions in glucose transport capacity...
  16. ncbi Identification of putative downstream genes of Oct-3, a pluripotent cell-specific transcription factor
    Y Saijoh
    Tokyo Metropolitan Institute of Medical Science, Bunkyo ku, Japan
    Genes Cells 1:239-52. 1996
    ..In order to study how pluripotency is maintained, it is essential to know what genes are regulated by Oct-3...
  17. ncbi Hypoxia regulation of facilitated glucose transporter-1 and glucose transporter-3 in mouse chondrocytes mediated by HIF-1alpha
    Bu Fang Ren
    Shanghai Institute of Traumatology and Orthopaedics and Department of Orthopaedics, Ruijin Hospital Affiliated to Shanghai Jiaotong University, Shanghai 200025, China
    Joint Bone Spine 75:176-81. 2008
    ..Chondrocytes reside in a hypoxic environment; they utilize glucose as the main energy source. Facilitated glucose transport represents the first rate-limiting step in glucose metabolism...
  18. ncbi Oxygen-regulated expression of GLUT-1, GLUT-3, and VEGF in the mouse blastocyst
    Karen L Kind
    Research Centre for Reproductive Health, Department of Obstetrics and Gynaecology, University of Adelaide, The Queen Elizabeth Hospital, Woodville, South Australia, Australia
    Mol Reprod Dev 70:37-44. 2005
    ..001). These results suggest that the preimplantation mouse embryo has the capacity to detect and respond to low oxygen availability with changes in expression of oxygen-regulated genes...
  19. pmc Keratins regulate protein biosynthesis through localization of GLUT1 and -3 upstream of AMP kinase and Raptor
    Preethi Vijayaraj
    Abteilung für Zellbiochemie, Institut für Biochemie und Molekularbiologie and 2 Bonner Forum Biomedizin, Universitat Bonn, 53115 Bonn, Germany
    J Cell Biol 187:175-84. 2009
    ..Our findings demonstrate a novel keratin function upstream of mTOR signaling via GLUT localization and have implications for pathomechanisms and therapy approaches for keratin disorders and the analysis of other gene families...
  20. pmc Placental glucose and amino acid transport in calorie-restricted wild-type and Glut3 null heterozygous mice
    Amit Ganguly
    Division of Neonatology and Developmental Biology, Neonatal Research Center, Department of Pediatrics, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California 90095 1752, USA
    Endocrinology 153:3995-4007. 2012
    ..CR) decreased placenta and fetal weights in wild-type (wt) and glucose transporter (Glut) 3 heterozygous null (glut3(+/-)) mice...
  21. pmc Hypoxic adaptation engages the CBP/CREST-induced coactivator complex of Creb-HIF-1α in transactivating murine neuroblastic glucose transporter
    Shanthie Thamotharan
    Department of Pediatrics, Division of Neonatology and Developmental Biology, Neonatal Research Center, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA 90095, USA
    Am J Physiol Endocrinol Metab 304:E583-98. 2013
    We have shown in vitro a hypoxia-induced time-dependent increase in facilitative glucose transporter isoform 3 (GLUT3) expression in N2A murine neuroblasts...
  22. doi Reprogramming- and pluripotency-associated membrane proteins in mouse stem cells revealed by label-free quantitative proteomics
    Jie Hao
    Tianjin State Laboratory of Protein Science, College of Life Sciences, Nankai University, Tianjin 300071, China
    J Proteomics 86:70-84. 2013
    ..Moreover, knock-down of glucose transporter 3 in ESCs impaired the beating function of ESC-derived cardiomyocytes, suggesting its potential role in mediating stem cell differentiation...
  23. doi NFκB up-regulation of glucose transporter 3 is essential for hyperactive mammalian target of rapamycin-induced aerobic glycolysis and tumor growth
    Xiaojun Zha
    Department of Biochemistry and Molecular Biology, School of Basic Medicine, Anhui Medical University, Hefei, China
    Cancer Lett 359:97-106. 2015
    ..fibroblasts (MEFs) and human cancer cell lines consistently indicate that the expression of glucose transporter 3 (Glut3) is dramatically up-regulated by mTOR...
  24. pmc Copy-Number Variation of the Glucose Transporter Gene SLC2A3 and Congenital Heart Defects in the 22q11.2 Deletion Syndrome
    Elisabeth E Mlynarski
    Division of Human Genetics, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Am J Hum Genet 96:753-64. 2015
    ..Our analysis revealed that a duplication of SLC2A3 was the most frequent CNV identified in the first cohort...
  25. pmc A pair of co-opted retroviral envelope syncytin genes is required for formation of the two-layered murine placental syncytiotrophoblast
    Anne Dupressoir
    Unité des rétrovirus endogènes et éléments rétroïdes des eucaryotes supérieurs, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 8122, and Unité de Génomique Fonctionnelle, Institut Gustave Roussy, 94805 Villejuif, France
    Proc Natl Acad Sci U S A 108:E1164-73. 2011
    ..Although some are absolutely required for completion of pregnancy, others are still amenable to "epigenetic" compensations, thus illustrating the complexity of the molecular machinery that developed during placental evolution...
  26. doi Glucose uptake mediated by glucose transporter 1 is essential for early tooth morphogenesis and size determination of murine molars
    Hiroko Ida-Yonemochi
    Division of Anatomy and Cell Biology of the Hard Tissue, Department of Tissue Regeneration and Reconstruction, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951 8514, Japan
    Dev Biol 363:52-61. 2012
    ....
  27. doi Cytoprotective effects of hesperetin and hesperidin against amyloid β-induced impairment of glucose transport through downregulation of neuronal autophagy
    Shang Ming Huang
    Department of Food Science and Biotechnology, National Chung Hsing University, Taichung, Taiwan
    Mol Nutr Food Res 56:601-9. 2012
    ..This study investigated whether flavonoids, such as hesperetin and hesperidin, inhibited amyloid β (Aβ)-impaired glucose utilization through regulating cellular autophagy in insulin-stimulated neuronal cells...
  28. pmc A systematic analysis of a deep mouse epididymal sperm proteome
    Theodore Chauvin
    School of Molecular Biosciences, Washington State University, Spokane, Washington 99201, USA
    Biol Reprod 87:141. 2012
    ..This proteome should prove a useful tool for assembly and testing of protein networks important for sperm function...
  29. pmc Temporal and spatial distribution of murine placental and brain GLUT3-luciferase transgene as a readout of in vivo transcription
    Shanthie Thamotharan
    Department of Pediatrics, Division of Neonatology and Developmental Biology, Neonatal Research Center, David Geffen School of Medicine at University of California Los Angeles UCLA, Los Angeles, CA 90095, USA
    Am J Physiol Endocrinol Metab 304:E254-66. 2013
    To investigate in vivo transcription of the facilitative glucose transporter isoform-GLUT3 gene, we created GLUT3-firefly luciferase transgenic mouse lines that demonstrate tissue-specific [adult: brain > testis ≥ skeletal muscle &..
  30. pmc Creb1-Mecp2-(m)CpG complex transactivates postnatal murine neuronal glucose transporter isoform 3 expression
    Yongjun Chen
    Department of Pediatrics, Division of Neonatology and Developmental Biology, Neonatal Research Center, David Geffen School of Medicine University of California LosAngeles, Los Angeles, California 90095 1752, USA
    Endocrinology 154:1598-611. 2013
    The murine neuronal facilitative glucose transporter isoform 3 (Glut3) is developmentally regulated, peaking in expression at postnatal day (PN)14...
  31. pmc The glucose transporter family: structure, function and tissue-specific expression
    G W Gould
    Department of Biochemistry, University of Glasgow, Scotland, U K
    Biochem J 295:329-41. 1993
  32. ncbi Gestational changes of glucose transporter gene expression in the mouse placenta and decidua
    M Yamaguchi
    Department of Obstetrics and Gynecology, Osaka University Medical School, Japan
    J Endocrinol Invest 19:567-9. 1996
    ..In this study, the gestational changes of GLUT1 and GLUT3 mRNA level in the mouse placenta and decidua were analyzed by Northern blot analysis...
  33. pmc Localization of low-density detergent-resistant membrane proteins in intact and acrosome-reacted mouse sperm
    Patricia V Miranda
    Department of Veterinary and Animal Sciences, University of Massachusetts, Amherst, MA, USA
    Biol Reprod 80:897-904. 2009
    ..Taking into consideration the requirement of the acrosome reaction for sperm to become fusogenic, these results suggest that membrane raft dynamics may have a role in sperm-egg membrane interaction...
  34. doi Vitamin C enters mouse T cells as dehydroascorbic acid in vitro and does not recapitulate in vivo vitamin C effects
    Hyung Gun Maeng
    Department of Anatomy and Tumor Immunity Medical Research Center, Seoul National University College of Medicine, 28 Yongon Dong, Chongno Gu, Seoul 110 799, Republic of Korea
    Immunobiology 214:311-20. 2009
    ..Application of vitamin C to T cells in vitro did not recapitulate previously reported in vivo responses to vitamin C, suggesting that in vivo, vitamin C modulates T cells indirectly through other components of the microenvironment...
  35. ncbi Canine brain glucose transporter 3: gene sequence, phylogenetic comparisons and analysis of functional sites
    N D Borson
    Department of Biochemistry and Molecular Biology, School of Medicine, University of Minnesota, Duluth, 55812, USA
    Gene 168:251-6. 1996
    There has been a sparsity of various mammalian neuronal glucose transporter 3-encoding sequences(Glut3) available for the purposes of alignment studies...
  36. ncbi Hyperglycemia reduces mitochondrial content and glucose transporter expression in mouse embryos developing in vitro
    Xing Hui Shen
    Department of Animal Sciences, Chungbuk National University, Cheongju, Chungbuk, Korea
    J Reprod Dev 55:534-41. 2009
    ..Both transcripts and protein synthesis of the glucose transporters Glut1 and Glut3 were reduced in blastocysts cultured in the presence of either 25 or 55 mM glucose...
  37. pmc Syncytin-A knockout mice demonstrate the critical role in placentation of a fusogenic, endogenous retrovirus-derived, envelope gene
    Anne Dupressoir
    Unité des rétrovirus endogènes et éléments rétroïdes des eucaryotes supérieurs, Unité Mixte de Recherche 8122, Centre National de Recherche Scientifique, Institut Gustave Roussy, 94805 Villejuif, and Université Paris Sud, 91405 Orsay, France
    Proc Natl Acad Sci U S A 106:12127-32. 2009
    ....
  38. ncbi Mouse chromosomal location of three epithelial sodium channel subunit genes and an apical sodium chloride cotransporter gene
    B G Pathak
    Mammalian Genetics Laboratory, ABL Basic Research Program, NCI Frederick Cancer Research and Development Center, Frederick, Maryland, 21702, USA
    Genomics 33:124-7. 1996
    ..These loci map to previously defined homologous regions between human and mouse chromosomes and provide additional information regarding human/mouse comparative mapping...
  39. pmc Brain glucose transporter (Glut3) haploinsufficiency does not impair mouse brain glucose uptake
    Charles A Stuart
    East Tennessee State University Quillen College of Medicine, Johnson City, TN, USA
    Brain Res 1384:15-22. 2011
    ..Glut1 is an endothelial marker and is the principal glucose transporter of the blood-brain barrier. Glut3 and Glut6 are expressed in glial cells and neural cells...
  40. pmc Fetal overgrowth in the Cdkn1c mouse model of Beckwith-Wiedemann syndrome
    Simon J Tunster
    Cardiff School of Biosciences, Cardiff University, Cardiff, CF10 3AX, UK
    Dis Model Mech 4:814-21. 2011
    ....
  41. pmc Endotoxin-induced enhancement of glucose influx into murine peritoneal macrophages via GLUT1
    M Fukuzumi
    Department of Microbiology, Ehime University School of Medicine, Japan
    Infect Immun 64:108-12. 1996
    ..These results suggest that macrophage responses to LPS are supported by a rapid and sustained glucose influx via GLUT1 and that this is a participating factor in the development of systemic hypoglycemia when endotoxemia is prolonged...
  42. doi Altered placental function of 11beta-hydroxysteroid dehydrogenase 2 knockout mice
    Caitlin S Wyrwoll
    Endocrinology Unit, Queen s Medical Research Institute, Centre for Cardiovascular Science, Edinburgh, United Kingdom
    Endocrinology 150:1287-93. 2009
    ..Our data suggest that restriction of fetal growth in 11beta-HSD2(-/-) mice is mediated, at least in part, via altered placental transport of nutrients and reduction in placental vascularization...
  43. pmc Gene expression of GLUT3 glucose transporter regulated by glucose in vivo in mouse brain and in vitro in neuronal cell cultures from rat embryos
    S Nagamatsu
    Department of Biochemistry, Kyorin University School of Medicine, Tokyo, Japan
    Biochem J 300:125-31. 1994
    This study was designed to determine whether glucose regulates the gene expression of glucose transporter GLUT3 in neurons...
  44. ncbi Difference in allelic expression of genes probably associated with tumor progression in murine fibrosarcomas and cell lines
    H Ohtsuka
    First Department of Biochemistry, Niigata University School of Medicine
    Jpn J Cancer Res 85:1015-22. 1994
    ..In some of the tumors and cell lines, p53, E-cadherin and Glut3 genes showed remarkable differences in allelic expression, one allele being poorly expressed...
  45. ncbi Glucose transporter proteins in brain
    F Maher
    National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892
    FASEB J 8:1003-11. 1994
    ..concentration at the blood-brain barrier as well as in parenchymal cells (45-kDa form), most likely in astrocytes, GLUT3 expressed in neurons, and GLUT5 in microglia...
  46. ncbi Glucose transporter expression and functional role of hexokinase in insulin biosynthesis in mouse beta TC3 cells
    S Nagamatsu
    Department of Biochemistry, Kyorin University School of Medicine, Tokyo, Japan
    Am J Physiol 269:C480-6. 1995
    ....
  47. ncbi Evidence for a family of human glucose transporter-like proteins. Sequence and gene localization of a protein expressed in fetal skeletal muscle and other tissues
    T Kayano
    Howard Hughes Medical Institute, Department of Biochemistry, University of Chicago, Illinois 60637
    J Biol Chem 263:15245-8. 1988
    ..The identification and characterization of a third human glucose transporter-related protein suggests that there is a family of proteins having similar sequences and structures which are involved in nutrient transport by mammalian cells...
  48. ncbi Expression of mouse-GLUT3 and human-GLUT3 glucose transporter proteins in brain
    F Maher
    Experimental Diabetes, Metabolism and Nutrition Section, NIDDK, National Institutes of Health, Bethesda, MD 20892
    Biochem Biophys Res Commun 182:703-11. 1992
    Polyclonal anti-peptide antisera were raised to the C-terminal sequence of mouse- and human-GLUT3 glucose transporter isoforms...
  49. ncbi Expression of the brain-type glucose transporter is restricted to brain and neuronal cells in mice
    G W Gould
    Department of Biochemistry, University of Glasgow, Scotland, United Kingdom
    Diabetologia 35:304-9. 1992
    ..blot analysis of human tissues has demonstrated the expression of the brain-type glucose transporter isoform (GLUT 3) in liver, muscle and fat, raising the possibility that this transporter isoform may play a role in the regulation ..
  50. ncbi The rhombotin gene family encode related LIM-domain proteins whose differing expression suggests multiple roles in mouse development
    L Foroni
    MRC Laboratory of Molecular Biology, Cambridge, U K
    J Mol Biol 226:747-61. 1992
    ..These results suggest multiple cellular targets for the action of these proteins during development...
  51. ncbi Assignment of a novel protein tyrosine phosphatase gene (Hcph) to mouse chromosome 6
    T Yi
    Department of Biochemistry, St Jude Children s Research Hospital, Memphis, Tennessee 38105
    Genomics 14:793-5. 1992
    ..Using a genomic probe in interspecific backcross analysis, the murine Hcph gene maps to mouse Chromosome 6 and is tightly linked to the Tnfr-2 and Ly-4 genes...
  52. ncbi Molecular cloning of murine homologue dentatorubral-pallidoluysian atrophy (DRPLA) cDNA: strong conservation of a polymorphic CAG repeat in the murine gene
    M Oyake
    Department of Neurology, Niigata University School of Medicine, Japan
    Genomics 40:205-7. 1997
  53. ncbi Organization of the mouse microfibril-associated glycoprotein-2 (MAGP-2) gene
    C Frankfater
    Department of Medicine, Barnes Jewish Hospital, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Mamm Genome 11:191-5. 2000
    ..We have characterized both mRNA species and determined that they do not code for different variants of the protein...
  54. ncbi Prenatal expression of the GLUT4 glucose transporter in the mouse
    S J Vannucci
    Department of Pediatrics and Neuroscience and Anatomy, Hershey Medical Center, Penn State University College of Medicine, 17033, USA
    Dev Neurosci 22:274-82. 2000
    ..These findings suggest that GLUT4-mediated glucose transport may play important roles during development of the brain and nonneuronal tissues in the mouse embryo...
  55. ncbi Glucose uptake, utilization, and signaling in GLUT2-null islets
    M T Guillam
    Institute of Pharmacology and Toxicology, University of Lausanne, Switzerland
    Diabetes 49:1485-91. 2000
    ..We show that in the absence of GLUT2, no compensatory expression of either GLUT1 or GLUT3 is observed and that glucokinase is expressed at normal levels...
  56. pmc Targeted mutation of the murine arylhydrocarbon receptor nuclear translocator 2 (Arnt2) gene reveals partial redundancy with Arnt
    B Keith
    Departments of Medicine and Cell and Developmental Biology, Abramson Family Cancer Research Institute, and Howard Hughes Medical Institute, University of Pennsylvania, 421 Curie Boulevard, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 98:6692-7. 2001
    ..5. These results demonstrate that Arnt and Arnt2 have both unique and overlapping essential functions in embryonic development...
  57. ncbi Immunohistochemical localization and quantification of glucose transporters in the mouse brain
    C Choeiri
    School of Psychology, University of Ottawa, Vanier Building, Room 202, Ottawa, ON, Canada K1N 6N5
    Neuroscience 111:19-34. 2002
    ..In the brain, Glut2, Glut5 and Glut8 are found at relatively low levels whereas Glut1, Glut3 and Glut4 were reported in abundance in several brain regions...
  58. ncbi Differential screening of a PCR-generated mouse embryo cDNA library: glucose transporters are differentially expressed in early postimplantation mouse embryos
    D E Smith
    Department of Cell and Developmental Biology, Roche Research Center, Nutley, NJ 07110
    Development 116:555-61. 1992
    ..Expression of Glut-1 was fairly widespread in the embryo at 8.5 dpc, but by 10.5 dpc expression was down-regulated and was observed in the eye and the spinal cord.(ABSTRACT TRUNCATED AT 250 WORDS)..
  59. pmc In vitro analysis of the glucose-transport system in GLUT4-null skeletal muscle
    J W Ryder
    Department of Clinical Physiology, Karolinska Hospital, S 171 76, Stockholm, Sweden
    Biochem J 342:321-8. 1999
    ..Neither GLUT3 nor GLUT5 appeared to account for insulin-stimulated glucose-transport activity in wild-type or GLUT4-null muscle...
  60. pmc Adaptation of nutrient supply to fetal demand in the mouse involves interaction between the Igf2 gene and placental transporter systems
    Miguel Constancia
    Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Babraham Research Campus, Cambridge CB2 4AT, United Kingdom
    Proc Natl Acad Sci U S A 102:19219-24. 2005
    ..this up-regulation of transport occurs, at least in part, through increased expression of the transporter genes Slc2a3 and Slc38a4, the imprinted member of the System A amino acid transporter gene family...
  61. ncbi Placental glucose transporter expression is regulated by glucocorticoids
    T Hahn
    Institute of Histology and Embryology, University of Graz, Austria
    J Clin Endocrinol Metab 84:1445-52. 1999
    ..In the present study, the glucose carrier proteins GLUT1 and GLUT3 were localized in the trophoblast and endothelium of the human, rat, and mouse placenta...
  62. pmc Identification of oscillatory genes in somitogenesis from functional genomic analysis of a human mesenchymal stem cell model
    Dilusha A William
    Division of Human Genetics and Orthopaedic Surgery, Children s Hospital of Philadelphia, 3615 Civic Center Blvd, Philadelphia, PA 19104, USA
    Dev Biol 305:172-86. 2007
    ..Our results demonstrate that human and mouse in vitro models can recapitulate oscillatory expression observed in embryo and that a number of genes in multiple developmental pathways display dynamic expression in vitro...
  63. ncbi Characterization of genes which exhibit reduced expression during the retinoic acid-induced differentiation of F9 teratocarcinoma cells: involvement of cyclin D3 in RA-mediated growth arrest
    T N Faria
    Department of Pharmacology, Cornell University Medical College, New York, NY 10021, USA
    Mol Cell Endocrinol 143:155-66. 1998
    ..described in other contexts: 1-4 (cyclin D3); 2-10 (pyruvate kinase); 2-12 (glutathione S-transferase); and 2-17 (GLUT 3)...
  64. pmc Synergistic function of E2F7 and E2F8 is essential for cell survival and embryonic development
    Jing Li
    Department of Molecular Virology, The Ohio State University, Columbus, OH 43210, USA
    Dev Cell 14:62-75. 2008
    ..These results identify E2F7 and E2F8 as a unique repressive arm of the E2F transcriptional network that is critical for embryonic development and control of the E2F1-p53 apoptotic axis...
  65. doi p53 regulates glucose metabolism through an IKK-NF-kappaB pathway and inhibits cell transformation
    Keiko Kawauchi
    Department of Molecular Oncology, Institute of Gerontology, Nippon Medical School, Kosugi cho 1 396, Nakahara ku, Kawasaki shi, Kanagawa 211 8533, Japan
    Nat Cell Biol 10:611-8. 2008
    ..Activation of NF-kappaB, by loss of p53, caused an increase in the rate of aerobic glycolysis and upregulation of Glut3. Oncogenic Ras-induced cell transformation and acceleration of aerobic glycolysis in p53-deficient cells were ..
  66. ncbi Maternal hyperglycemia alters glucose transport and utilization in mouse preimplantation embryos
    K H Moley
    Department of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Physiol 275:E38-47. 1998
    ..These findings suggest that, in response to a maternal diabetic state, preimplantation mouse embryos experience a decrease in glucose utilization directly related to a decrease in glucose transport at both the mRNA and protein levels...
  67. pmc Overexpression of thioredoxin-1 reduces oxidative stress in the placenta of transgenic mice and promotes fetal growth via glucose metabolism
    Takashi Umekawa
    Department of Obstetrics and Gynecology, Mie University Graduate School of Medicine, 2 174 Edobashi, Tsu, Mie 514 8507, Japan
    Endocrinology 149:3980-8. 2008
    ..In particular, increased hTRX-1 activity and the resulting modified placental redox state may play an important role in fetal growth by increasing the availability of glucose...
  68. pmc Endocannabinoid signaling controls pyramidal cell specification and long-range axon patterning
    Jan Mulder
    Department of Neuroscience, Retzius vag 8, and Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Scheeles vag 1, Karolinska Institutet, 17177 Stockholm, Sweden
    Proc Natl Acad Sci U S A 105:8760-5. 2008
    ..Likewise, axonal pathfinding becomes impaired after in utero pharmacological blockade of CB(1)Rs. Overall, eCBs are fundamental developmental cues controlling pyramidal cell development during corticogenesis...
  69. doi Molecular identification and functional characterization of the vitamin C transporters expressed by Sertoli cells
    Constanza Angulo
    Instituto de Bioquimica, Facultad de Ciencias, Universidad Austral de Chile, Valdivia, Chile
    J Cell Physiol 217:708-16. 2008
    ..OMG) transport by 42GPA9 Sertoli cells correspond to facilitative hexose transporters GLUT1, GLUT2 and GLUT3 expressed in these cells...
  70. doi Metabolic mode peculiar to Meckel's cartilage: immunohistochemical comparisons of hypoxia-inducible factor-1alpha and glucose transporters in developing endochondral bones in mice
    Yasunori Sakakura
    Division of Anatomy, Department of Oral Growth and Development, School of Dentistry, Heath Sciences University of Hokkaido, Hokkaido, Japan
    Eur J Oral Sci 116:341-52. 2008
    ..for hypoxia-inducible factor-1alpha (HIF-1alpha), glucose transporter 1 (GLUT1), glucose transporter 3 (GLUT3), and glucose transporter 5 (GLUT5), and using enzyme histochemistry for glucose-6-phosphate isomerase (GPI), ..
  71. ncbi A novel LPS-inducible C-type lectin is a transcriptional target of NF-IL6 in macrophages
    M Matsumoto
    Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, Japan
    J Immunol 163:5039-48. 1999
    ..The Mincle gene locus was mapped at 0.6 centiMorgans proximal to CD4 on mouse chromosome 6...
  72. ncbi Novel mouse microsatellites: primer sequences and chromosomal location
    T Suda
    First Department of Biochemistry, Niigata University School of Medicine, Japan
    DNA Res 1:169-74. 1994
    ..The microsatellites were distributed to most chromosomes except for chromosomes 16 and 19. These novel markers with defined locations are useful in linkage and genome mapping studies...
  73. ncbi Physical mapping of the autoimmune disease susceptibility locus, Bphs: co-localization with a cluster of genes from the TNF receptor superfamily on mouse chromosome 6
    N D Meeker
    Department of Veterinary Pathobiology, 2001 South Lincoln Ave, University of Illinois at Urbana Champaign, Urbana, Illinois 61802, USA
    Mamm Genome 10:858-63. 1999
    ..However, the location of Bphs, together with physiologic effects it shares with Tnfr1 activation, suggest that Bphs may prove to be another member of the TNF receptor superfamily...

Research Grants3

  1. Role of Placental Transport In Fetal Growth
    Sherin Devaskar; Fiscal Year: 2008
    ..b>GLUT 3, a specific facilitative glucose transporter is expressed in the trophoectoderm/trophoblasts of the placenta and ..
  2. POSTNATAL ASPECTS OF A GLUCOSE TRANSPORTER
    Sherin Devaskar; Fiscal Year: 2008
    ..b>GLUT 3, a specific facilitative glucose transporter is the predominant neuronal isoform that meets the high demand of ..
  3. PERINATAL METABOLIC AND HORMONAL EFFECTS
    Sherin U Devaskar; Fiscal Year: 2010
    ..The results of our proposed investigations will fill vital gaps in our knowledge and provide the molecular and cellular basis for perinatal nutritional perturbations causing permanent changes in feeding behavior/energy expenditure. ..