Slc2a2

Summary

Gene Symbol: Slc2a2
Description: solute carrier family 2 (facilitated glucose transporter), member 2
Alias: AI266973, Glut-2, Glut2, solute carrier family 2, facilitated glucose transporter member 2, glucose transporter type 2, liver, liver-type glucose transporter
Species: mouse

Top Publications

  1. pmc The nucleotide sequence of cDNA for a mouse liver-type glucose transporter protein
    T Asano
    Institute for Diabetes Care and Research, Asahi Life Foundation, Tokyo, Japan
    Nucleic Acids Res 17:6386. 1989
  2. pmc Simple-sugar meals target GLUT2 at enterocyte apical membranes to improve sugar absorption: a study in GLUT2-null mice
    F Gouyon
    INSERM U505, UPMC, Paris, France
    J Physiol 552:823-32. 2003
  3. ncbi Insulin internalizes GLUT2 in the enterocytes of healthy but not insulin-resistant mice
    Vanessa Tobin
    Universite Pierre et Marie Curie Paris 6, Unité Mixte de Recherche S 872, Paris, France
    Diabetes 57:555-62. 2008
  4. pmc Context-specific α- to-β-cell reprogramming by forced Pdx1 expression
    Yu Ping Yang
    Vanderbilt University Program in Developmental Biology, Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Genes Dev 25:1680-5. 2011
  5. ncbi PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum
    M F Offield
    Department of Cell Biology, Vanderbilt University School of Medicine, Nashville, TN 37232 2175, USA
    Development 122:983-95. 1996
  6. ncbi Early diabetes and abnormal postnatal pancreatic islet development in mice lacking Glut-2
    M T Guillam
    Institute of Pharmacology and Toxicology, Lausanne, Switzerland
    Nat Genet 17:327-30. 1997
  7. ncbi Transgenic reexpression of GLUT1 or GLUT2 in pancreatic beta cells rescues GLUT2-null mice from early death and restores normal glucose-stimulated insulin secretion
    B Thorens
    Institute of Pharmacology and Toxicology, 27, Rue du Bugnon, CH 1005 Lausanne and Swiss Institute for Experimental Research on Cancer, Ch des Boveresses, 1066 Epalinges, Switzerland
    J Biol Chem 275:23751-8. 2000
  8. ncbi Persistent expression of HNF6 in islet endocrine cells causes disrupted islet architecture and loss of beta cell function
    M Gannon
    Department of Cell Biology, Vanderbilt University School of Medicine, Nashville, TN 37232 2175, USA
    Development 127:2883-95. 2000
  9. ncbi Glucose uptake, utilization, and signaling in GLUT2-null islets
    M T Guillam
    Institute of Pharmacology and Toxicology, University of Lausanne, Switzerland
    Diabetes 49:1485-91. 2000
  10. pmc Targeted deletion of a cis-regulatory region reveals differential gene dosage requirements for Pdx1 in foregut organ differentiation and pancreas formation
    Yoshio Fujitani
    Vanderbilt Program in Developmental Biology and Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2175, USA
    Genes Dev 20:253-66. 2006

Research Grants

  1. FUNCTION OF A GROWTH INDUCED GENE IN LIVER REGENERATION
    KLAUS KAESTNER; Fiscal Year: 2003
  2. Expression profiling of human islets
    KLAUS KAESTNER; Fiscal Year: 2006
  3. Nutrition, Early Development and Glucose Metabolism
    Patricia Vuguin; Fiscal Year: 2007
  4. Development of C57BL/6 ES cell technology for high thoughput use.
    KLAUS KAESTNER; Fiscal Year: 2007
  5. FUNCTIONAL GENOMICS OF THE BETA-CELL
    KLAUS KAESTNER; Fiscal Year: 2007
  6. Liver Biology, Development and Disease
    KLAUS KAESTNER; Fiscal Year: 2008

Scientific Experts

  • Peter M Clark
  • R Scott Heller
  • Hong Fu
  • Sang Ki Park
  • B Thorens
  • B Breant
  • Jennifer L Plank
  • Kazuaki Ohtsubo
  • Patricia M Vuguin
  • E Chankiewitz
  • Javairiah Fatima
  • KLAUS KAESTNER
  • Emilie Stolarczyk
  • Sui Wang
  • Pedro L Herrera
  • Armelle Leturque
  • Maude Le Gall
  • Patricia Serradas
  • Edith Brot-Laroche
  • Mark A Magnuson
  • Maike Sander
  • Christophe Magnan
  • Lourdes Mounien
  • M T Guillam
  • Christopher V E Wright
  • Isabella Artner
  • Philip A Seymour
  • James R Dotimas
  • Shelley B Nelson
  • Gokul Kesavan
  • R Burcelin
  • Chang Qing Xia
  • Pia V Röder
  • Christophe M Lamy
  • Christopher P Corpe
  • Magdalena A Mazur
  • Jin Hyuk Jung
  • Giuseppe R Diaferia
  • Matthias Hebrok
  • Fabien Delaere
  • Hiroko Ida-Yonemochi
  • Chutima Talchai
  • David A Cano
  • Amal Ait-Omar
  • Fabrizio Thorel
  • Mayrin C Medina
  • Ken T Coppieters
  • B Valtat
  • Yanyun Gu
  • Yu Ping Yang
  • Kai Hui Hu He
  • JieLi Lu
  • Georg Mellitzer
  • Guoqiang Gu
  • Hermann Koepsell
  • Preethi Vijayaraj
  • Laura A Crawford
  • Anne Houllier
  • Hong Soon Kang
  • June Chunqiu Hou
  • Yassine Sakar
  • Daniel F Boyer
  • Marc Foretz
  • Jin Xu
  • Xiuyun Jiang
  • Vanessa Tobin
  • Constanza Angulo
  • Claudia Zahn
  • Agueda Gonzalez-Rodriguez
  • David Tarussio
  • Nell Marty
  • Maureen Gannon
  • Patrice D Cani
  • Palle Serup
  • Michelle J Doyle
  • R Li
  • Hans Georg Joost
  • Wei Zhang
  • Junji Fujikura
  • G Waeber
  • Bing Li
  • Patrick W Heiser
  • Wataru Nishimura
  • Isabelle Bady
  • Yoshio Fujitani
  • Bangyan L Stiles
  • Patrick Collombat
  • Christina Osswald
  • Korinna D Henseleit
  • Khoi Chu

Detail Information

Publications114 found, 100 shown here

  1. pmc The nucleotide sequence of cDNA for a mouse liver-type glucose transporter protein
    T Asano
    Institute for Diabetes Care and Research, Asahi Life Foundation, Tokyo, Japan
    Nucleic Acids Res 17:6386. 1989
  2. pmc Simple-sugar meals target GLUT2 at enterocyte apical membranes to improve sugar absorption: a study in GLUT2-null mice
    F Gouyon
    INSERM U505, UPMC, Paris, France
    J Physiol 552:823-32. 2003
    The physiological significance of the presence of GLUT2 at the food-facing pole of intestinal cells is addressed by a study of fructose absorption in GLUT2-null and control mice submitted to different sugar diets...
  3. ncbi Insulin internalizes GLUT2 in the enterocytes of healthy but not insulin-resistant mice
    Vanessa Tobin
    Universite Pierre et Marie Curie Paris 6, Unité Mixte de Recherche S 872, Paris, France
    Diabetes 57:555-62. 2008
    ..sugar uptake to match dietary load, resulting from a rapid transient translocation of the fructose/glucose GLUT2 transporter to the brush border membrane (BBM) of enterocytes...
  4. pmc Context-specific α- to-β-cell reprogramming by forced Pdx1 expression
    Yu Ping Yang
    Vanderbilt University Program in Developmental Biology, Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Genes Dev 25:1680-5. 2011
    ..Our findings reveal that Pdx1 can work single-handedly as a potent context-dependent autonomous reprogramming agent, and suggest a postnatal differentiation evaluation stage involved in normal endocrine maturation...
  5. ncbi PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum
    M F Offield
    Department of Cell Biology, Vanderbilt University School of Medicine, Nashville, TN 37232 2175, USA
    Development 122:983-95. 1996
    ..a local absence of the normal columnar epithelial lining, villi, and Brunner's glands, which are replaced by a GLUT2-positive cuboidal epithelium resembling the bile duct lining...
  6. ncbi Early diabetes and abnormal postnatal pancreatic islet development in mice lacking Glut-2
    M T Guillam
    Institute of Pharmacology and Toxicology, Lausanne, Switzerland
    Nat Genet 17:327-30. 1997
    ..Glut-2 is thus required to maintain normal glucose homeostasis and normal function and development of the endocrine pancreas. Its absence leads to symptoms characteristic of non-insulin-dependent diabetes mellitus...
  7. ncbi Transgenic reexpression of GLUT1 or GLUT2 in pancreatic beta cells rescues GLUT2-null mice from early death and restores normal glucose-stimulated insulin secretion
    B Thorens
    Institute of Pharmacology and Toxicology, 27, Rue du Bugnon, CH 1005 Lausanne and Swiss Institute for Experimental Research on Cancer, Ch des Boveresses, 1066 Epalinges, Switzerland
    J Biol Chem 275:23751-8. 2000
    b>GLUT2-null mice are hyperglycemic, hypoinsulinemic, hyperglucagonemic, and glycosuric and die within the first 3 weeks of life...
  8. ncbi Persistent expression of HNF6 in islet endocrine cells causes disrupted islet architecture and loss of beta cell function
    M Gannon
    Department of Cell Biology, Vanderbilt University School of Medicine, Nashville, TN 37232 2175, USA
    Development 127:2883-95. 2000
    ..several mature beta cell markers were expressed in beta cells of transgenic islets, the glucose transporter GLUT2 was absent or severely reduced...
  9. ncbi Glucose uptake, utilization, and signaling in GLUT2-null islets
    M T Guillam
    Institute of Pharmacology and Toxicology, University of Lausanne, Switzerland
    Diabetes 49:1485-91. 2000
    We previously reported that pancreatic islet beta-cells from GLUT2-null mice lost the first phase but preserved the second phase of glucose-stimulated insulin secretion (GSIS)...
  10. pmc Targeted deletion of a cis-regulatory region reveals differential gene dosage requirements for Pdx1 in foregut organ differentiation and pancreas formation
    Yoshio Fujitani
    Vanderbilt Program in Developmental Biology and Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2175, USA
    Genes Dev 20:253-66. 2006
    ....
  11. ncbi Evidence from glut2-null mice that glucose is a critical physiological regulator of feeding
    Isabelle Bady
    Department of Physiology, Center for Integrative Genomics, University of Lausanne, Switzerland
    Diabetes 55:988-95. 2006
    ..Here, we evaluated feeding behavior in glut2-null mice, which express a transgenic glucose transporter in their beta-cells to rescue insulin secretion (..
  12. pmc MafB is required for islet beta cell maturation
    Isabella Artner
    Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, 723 Light Hall, Nashville, TN 37232, USA
    Proc Natl Acad Sci U S A 104:3853-8. 2007
    ..However, Pdx1, Nkx6.1, and GLUT2 were selectively lost in these insulin-deficient cells between E15.5 and E18.5...
  13. ncbi GLUT2 and the incretin receptors are involved in glucose-induced incretin secretion
    Patrice D Cani
    Institut de Medecine Moleculaire de Rangueil, I 2 MR, IFR31, CHU Rangueil, BP 84225, 31432 Toulouse Cedex 4, France
    Mol Cell Endocrinol 276:18-23. 2007
    ..We determined the role of GLUT2, GLP-1 or GIP receptors in glucose-induced incretins secretion, in the corresponding knockout mice...
  14. pmc The glucose transporter 2 undergoes plasma membrane endocytosis and lysosomal degradation in a secretagogue-dependent manner
    June Chunqiu Hou
    North General Hospital, New York, New York 10035, USA
    Endocrinology 150:4056-64. 2009
    ..We observed that expressed GLUT2 protein in the cultured Min6B1 cell line undergoes enhanced endocytosis at high extracellular glucose ..
  15. pmc Sustained Neurog3 expression in hormone-expressing islet cells is required for endocrine maturation and function
    Sui Wang
    Program in Developmental Biology and Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Proc Natl Acad Sci U S A 106:9715-20. 2009
    ..These findings demonstrate that Neurog3 is required not only for initiating endocrine cell differentiation, but also for promoting islet cell maturation and maintaining islet function...
  16. doi Detection of extracellular glucose by GLUT2 contributes to hypothalamic control of food intake
    Emilie Stolarczyk
    Unité Mixte de Recherche UMR S872, Centre de Recherche des Cordeliers, 15 rue de l Ecole de Medecine, Paris, F 75006 France
    Am J Physiol Endocrinol Metab 298:E1078-87. 2010
    The sugar transporter GLUT2, present in several tissues of the gut-brain axis, has been reported to be involved in the control of food intake...
  17. pmc In vivo conditional Pax4 overexpression in mature islet β-cells prevents stress-induced hyperglycemia in mice
    Kai Hui Hu He
    Department of Cell Physiology and Metabolism, University of Geneva, Geneva, Switzerland
    Diabetes 60:1705-15. 2011
    ....
  18. pmc GLUT2 accumulation in enterocyte apical and intracellular membranes: a study in morbidly obese human subjects and ob/ob and high fat-fed mice
    Amal Ait-Omar
    INSERM, U872, Team 9, Paris, France
    Diabetes 60:2598-607. 2011
    In healthy rodents, intestinal sugar absorption in response to sugar-rich meals and insulin is regulated by GLUT2 in enterocyte plasma membranes. Loss of insulin action maintains apical GLUT2 location...
  19. pmc Selective deletion of Pten in pancreatic beta cells leads to increased islet mass and resistance to STZ-induced diabetes
    Bangyan L Stiles
    Molecular and Medical Pharmacology, UCLA David Geffen School of Medicine, Los Angeles, California 90095, USA
    Mol Cell Biol 26:2772-81. 2006
    ..Our data demonstrate that PTEN loss in beta cells is not tumorigenic but beneficial. This suggests that modulating the PTEN-controlled signaling pathway is a potential approach for beta-cell protection and regeneration therapies...
  20. pmc The loss of GLUT2 expression by glucose-unresponsive beta cells of db/db mice is reversible and is induced by the diabetic environment
    B Thorens
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142
    J Clin Invest 90:77-85. 1992
    ..secretion by beta cells of diabetic db/db mice was studied by a pancreas perfusion technique, and the levels of GLUT2 protein in pancreatic islets were assessed by immunofluorescence microscopy and protein blot analysis...
  21. pmc Glucose transporter isotypes switch in T-antigen-transformed pancreatic beta cells growing in culture and in mice
    M Tal
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142 1479
    Mol Cell Biol 12:422-32. 1992
    ..Thus, abnormal glucose-induced secretion of insulin in prehyperplastic islets in mice was independent of changes in GLUT-2 expression and did not require induction of GLUT-1 expression...
  22. pmc Sequence of the mouse liver glucose transporter
    K Suzue
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142
    Nucleic Acids Res 17:10099. 1989
  23. ncbi Four human chromosome 3q and four human chromosome 21 loci map onto sheep chromosome 1q
    T E Broad
    Gene Mapping Unit, AgResearch Grasslands Research Centre, Palmerston North, New Zealand
    Mamm Genome 6:202-5. 1995
    ..to the distal region of human Chr 3q, are ceruloplasmin (CP), sucrase isomaltase (SI), glucose transporter 2 (GLUT2), and ectopic viral integration site 1 (EVI1)...
  24. pmc Normal hepatic glucose production in the absence of GLUT2 reveals an alternative pathway for glucose release from hepatocytes
    M T Guillam
    Institute of Pharmacology and Toxicology, University of Lausanne, 27, Rue du Bugnon, CH 1005 Lausanne, Switzerland
    Proc Natl Acad Sci U S A 95:12317-21. 1998
    ..been studied in detail but was assumed instead to depend on facilitated diffusion through the glucose transporter GLUT2. Here, we demonstrate that in the absence of GLUT2 no other transporter isoforms were overexpressed in liver and ..
  25. pmc Inactivation of the winged helix transcription factor HNF3alpha affects glucose homeostasis and islet glucagon gene expression in vivo
    K H Kaestner
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6145, USA
    Genes Dev 13:495-504. 1999
    ..We also showed that HNF3alpha could bind to and transactivate the proglucagon gene promoter. These observations invoke a central role for HNF3alpha in the regulatory control of islet genes essential for glucose homeostasis in vivo...
  26. pmc Hepatic nuclear factor 1-alpha directs nucleosomal hyperacetylation to its tissue-specific transcriptional targets
    M Parrizas
    Endocrinology and Hormonal Biochemistry Units, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain 08036
    Mol Cell Biol 21:3234-43. 2001
    ..We show that HNF1-alpha is essential for the expression of glut2 glucose transporter and L-type pyruvate kinase (pklr) genes in pancreatic insulin-producing cells, whereas in ..
  27. ncbi Characterisation of glucose transporters in the intact coronary artery endothelium in rats: GLUT-2 upregulated by long-term hyperglycaemia
    N Gaudreault
    Department of Physiology, University of British Columbia, 2146 Health Sciences Mall, Vancouver, B C, V6T 1Z3, Canada
    Diabetologia 47:2081-92. 2004
    ....
  28. ncbi Expression of the gene encoding the high-Km glucose transporter 2 by the early postimplantation mouse embryo is essential for neural tube defects associated with diabetic embryopathy
    R Li
    Developmental and Stem Cell Biology, Joslin Diabetes Center, 1 Joslin Place, Boston, MA 02215, USA
    Diabetologia 50:682-9. 2007
    ..The early postimplantation embryo expresses the gene encoding the high-Km GLUT2 (also known as SLC2A2) glucose transporter...
  29. pmc The tuberous sclerosis complex regulates trafficking of glucose transporters and glucose uptake
    Xiuyun Jiang
    Department of Surgery, Box 356410, University of Washington, 1959 NE Pacific, Seattle, WA 98195, USA
    Am J Pathol 172:1748-56. 2008
    ..in vitro revealed that Tsc2 regulates the membrane localization of the glucose transporter proteins (Glut)1, Glut2, and Glut4, and, therefore, glucose uptake...
  30. pmc Keratins regulate protein biosynthesis through localization of GLUT1 and -3 upstream of AMP kinase and Raptor
    Preethi Vijayaraj
    Abteilung für Zellbiochemie, Institut für Biochemie und Molekularbiologie and 2 Bonner Forum Biomedizin, Universitat Bonn, 53115 Bonn, Germany
    J Cell Biol 187:175-84. 2009
    ..Our findings demonstrate a novel keratin function upstream of mTOR signaling via GLUT localization and have implications for pathomechanisms and therapy approaches for keratin disorders and the analysis of other gene families...
  31. doi Alpha cell-specific Men1 ablation triggers the transdifferentiation of glucagon-expressing cells and insulinoma development
    JieLi Lu
    Laboratoire Génétique Moléculaire, Signalisation et Cancer, Centre National de Recherche Scientifique, UMR5201, Universite Claude Bernard Lyon1, Centre Leon Berard, Lyon, France
    Gastroenterology 138:1954-65. 2010
    ..The purpose of the current study was to address this issue in relation to islet tumor histogenesis...
  32. pmc Generation of functional insulin-producing cells in the gut by Foxo1 ablation
    Chutima Talchai
    Naomi Berrie Diabetes Center, Columbia University Medical Center, New York, New York, USA
    Nat Genet 44:406-12, S1. 2012
    ..The data indicate that Neurog3(+) enteroendocrine progenitors require active Foxo1 to prevent differentiation into Ins(+) cells. Foxo1 ablation in gut epithelium may provide an approach to restore insulin production in type 1 diabetes...
  33. doi N-Glycosylation modulates the membrane sub-domain distribution and activity of glucose transporter 2 in pancreatic beta cells
    Kazuaki Ohtsubo
    Disease Glycomics Team, Systems Glycobiology Research Group, Chemical Biology Department, RIKEN Max Planck Joint Research Center, RIKEN Global Research Cluster, Wako, Saitama 351 0198, Japan
    Biochem Biophys Res Commun 434:346-51. 2013
    The glucose transporter isoform, GLUT2, -mediated glucose sensing is essential for maintaining normal glucose-stimulated insulin secretion in pancreatic beta cells...
  34. pmc Microphthalmia transcription factor regulates pancreatic β-cell function
    Magdalena A Mazur
    Stem Cell Center, Lund University, Sweden
    Diabetes 62:2834-42. 2013
    ..Pax6 is an essential regulator of β-cell-specific factors like insulin and Glut2. Studies in the developing eye suggest that Pax6 interacts with Mitf to regulate pigment cell differentiation...
  35. pmc β1 integrin is a crucial regulator of pancreatic β-cell expansion
    Giuseppe R Diaferia
    Department of Experimental Oncology, European Institute of Oncology IEO, Via Adamello 16 20139, Milan, Italy
    Development 140:3360-72. 2013
    ..Collectively, our results demonstrate that β1 integrin receptors function as crucial positive regulators of β-cell expansion. ..
  36. pmc The role of sodium-coupled glucose co-transporter 3 in the satiety effect of portal glucose sensing
    Fabien Delaere
    Institut National de la Sante et de la Recherche Medicale, U 855, Lyon 69372, France Université de Lyon, Lyon 69008, France Université Lyon 1, Villeurbanne 69622, France AgroParisTech, ENGREF, Paris F 75732, France
    Mol Metab 2:47-53. 2012
    ..experiments using high infusions of glucose suggested a metabolic sensing involving glucose transporter 2 (GLUT2). Here we evaluated the afferent route for the signal and candidate molecules for detecting low glucose fluxes...
  37. pmc Mouse embryonic stem cells established in physiological-glucose media express the high KM Glut2 glucose transporter expressed by normal embryos
    Jin Hyuk Jung
    Section on Islet Cell and Regenerative Biology, Joslin Diabetes Center, Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA
    Stem Cells Transl Med 2:929-34. 2013
    b>Glut2 is one of the facilitative glucose transporters expressed by preimplantation and early postimplantation embryos. Glut2 is important for survival before embryonic day 10.5...
  38. pmc Cdc42/N-WASP signaling links actin dynamics to pancreatic β cell delamination and differentiation
    Gokul Kesavan
    Stem Cell Center, Department of Laboratory Medicine, Lund University, BMC B10 Klinikgatan 26, SE 22184 Lund, Sweden
    Development 141:685-96. 2014
    ..These findings elucidate how junctional actin dynamics via Cdc42/N-WASP signaling cell-autonomously control not only epithelial delamination but also cell differentiation during mammalian organogenesis. ..
  39. pmc The role of SGLT1 and GLUT2 in intestinal glucose transport and sensing
    Pia V Röder
    ZIEL Research Center for Nutrition and Food Sciences, Biochemistry Unit, Technische Universitat Munchen, Freising, Bavaria, Germany
    PLoS ONE 9:e89977. 2014
    Intestinal glucose absorption is mediated by SGLT1 whereas GLUT2 is considered to provide basolateral exit...
  40. doi Hypoglycemia-activated GLUT2 neurons of the nucleus tractus solitarius stimulate vagal activity and glucagon secretion
    Christophe M Lamy
    Department of Fundamental Neurosciences, University of Lausanne, Rue du Bugnon 9, 1005 Lausanne, Switzerland Department of Medicine, University of Fribourg, Rte Albert Gockel 1, 1700 Fribourg, Switzerland
    Cell Metab 19:527-38. 2014
    ..Here we show that GLUT2-expressing neurons of the nucleus of the tractus solitarius form a distinct population of hypoglycemia-activated ..
  41. pmc C-Abl inhibitor imatinib enhances insulin production by β cells: c-Abl negatively regulates insulin production via interfering with the expression of NKx2.2 and GLUT-2
    Chang Qing Xia
    Department of Hematology, Xuanwu Hospital, Capital Medical University, Bejing, China Department of Pathology, Immunology and Laboratory Medicine, Diabetes Center of Excellence, University of Florida, Gainesville, Florida, United States of America
    PLoS ONE 9:e97694. 2014
    ..Additionally, we found that c-Abl inhibition significantly enhanced the expression of glucose transporter GLUT2 on β cells...
  42. pmc Positron emission tomography probe demonstrates a striking concentration of ribose salvage in the liver
    Peter M Clark
    Departments of Microbiology, Immunology, and Molecular Genetics
    Proc Natl Acad Sci U S A 111:E2866-74. 2014
    ..We demonstrate that solute carrier family 2, member 2 (also known as GLUT2), a glucose transporter expressed in the liver, is one ribose transporter, but we do not know if others exist...
  43. pmc Diabetes regulates fructose absorption through thioredoxin-interacting protein
    James R Dotimas
    Department of Stem Cell and Regenerative Biology, Harvard University, Harvard Stem Cell Institute, Cambridge, United States
    elife 5:. 2016
    ..Our results indicate that Txnip is a critical regulator of fructose metabolism and suggest that a diabetic state can promote fructose uptake...
  44. ncbi Transcriptional activation of the GLUT2 gene by the IPF-1/STF-1/IDX-1 homeobox factor
    G Waeber
    Department of Internal Medicine B, University Hospital, Lausanne, Switzerland
    Mol Endocrinol 10:1327-34. 1996
    ..As the glucose transporter type 2 (GLUT2) gene expression is selectively decreased in the beta-pancreatic cells of experimental models of diabetes, we ..
  45. ncbi The transcription factors Nkx6.1 and Nkx6.2 possess equivalent activities in promoting beta-cell fate specification in Pdx1+ pancreatic progenitor cells
    Shelley B Nelson
    Department of Developmental and Cell Biology, University of California at Irvine, 4203 McGaugh Hall, Irvine, CA 92697 2300, USA
    Development 134:2491-500. 2007
    ..2 in endocrine differentiation are a consequence of their divergent spatiotemporal expression domains rather than their biochemical activities and implies that both Nkx6.1 and Nkx6.2 possess alpha- and beta-cell-specifying activities...
  46. doi Persistent glucose transporter expression on pancreatic beta cells from longstanding type 1 diabetic individuals
    Ken T Coppieters
    Type 1 Diabetes Center, The La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA
    Diabetes Metab Res Rev 27:746-54. 2011
    ..It remains questionable, however, whether these surviving cells can physiologically sense and respond to glucose stimuli...
  47. doi Glucose uptake mediated by glucose transporter 1 is essential for early tooth morphogenesis and size determination of murine molars
    Hiroko Ida-Yonemochi
    Division of Anatomy and Cell Biology of the Hard Tissue, Department of Tissue Regeneration and Reconstruction, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951 8514, Japan
    Dev Biol 363:52-61. 2012
    ..and an in vitro organ culture experiment with an inhibitor of GLUTs1/2, phloretin, and Glut1 and Glut2 short interfering RNA (siRNA)...
  48. pmc Intestinal dehydroascorbic acid (DHA) transport mediated by the facilitative sugar transporters, GLUT2 and GLUT8
    Christopher P Corpe
    Molecular and Clinical Nutrition Section, Digestive Diseases Branch, Intramural Research Program, NIDDK, National Institutes of Health, Bethesda, MD 20892 1372, USA
    J Biol Chem 288:9092-101. 2013
    ..Using Xenopus oocyte expression, we investigated whether facilitative glucose transporters GLUT2 and GLUT5-12 transported DHA...
  49. ncbi Differential screening of a PCR-generated mouse embryo cDNA library: glucose transporters are differentially expressed in early postimplantation mouse embryos
    D E Smith
    Department of Cell and Developmental Biology, Roche Research Center, Nutley, NJ 07110
    Development 116:555-61. 1992
    ..Expression of Glut-1 was fairly widespread in the embryo at 8.5 dpc, but by 10.5 dpc expression was down-regulated and was observed in the eye and the spinal cord.(ABSTRACT TRUNCATED AT 250 WORDS)..
  50. ncbi Developmental expression and cellular localization of glucose transporter molecules during mouse preimplantation development
    M Aghayan
    Department of Obstetrics and Gynecology, University of Pennsylvania Medical Center, Philadelphia 19104
    Development 115:305-12. 1992
    ..Of the latter, several facilitated transporters have been identified, including GLUT1 (erythrocyte/brain), GLUT2 (liver) and GLUT4 (adipose/muscle) isoforms...
  51. ncbi Cloning and characterization of rat pancreatic beta-cell/liver type glucose transporter gene: a unique exon/intron organization
    Y H Ahn
    Institute of Genetic Science, Yonsei University College of Medicine, Seoul, Korea
    Arch Biochem Biophys 323:387-96. 1995
    Four overlapping lambda genomic clones encoding rat pancreatic beta-cell/liver type glucose transporter (GLUT2) have been isolated and characterized. The gene is about 35 kb long and contains 14 exons and 13 introns...
  52. pmc Expression of the mouse corticotropin-releasing hormone gene in vivo and targeted inactivation in embryonic stem cells
    L J Muglia
    Division of Endocrinology, Children s Hospital, Boston, Massachusetts 02115
    J Clin Invest 93:2066-72. 1994
    ..Mice chimeric for each of two ES clones with an inactivated CRH allele are being used to generate animals with complete CRH deficiency...
  53. pmc The glucose transporter family: structure, function and tissue-specific expression
    G W Gould
    Department of Biochemistry, University of Glasgow, Scotland, U K
    Biochem J 295:329-41. 1993
  54. ncbi Pancreatic-specific expression of the glucose transporter type 2 gene: identification of cis-elements and islet-specific trans-acting factors
    C Bonny
    Department of Internal Medicine B, University Hospital of Lausanne, Switzerland
    Mol Endocrinol 9:1413-26. 1995
    ..of type II diabetes and has been correlated with a reduced gene expression of the glucose transporter type 2 (Glut2)...
  55. ncbi Chromosomal assignment of seven genes on canine chromosomes by fluorescence in situ hybridization
    M L Guevara-Fujita
    Department of Human Genetics, University of Michigan Medical School, 4708 Medical Science Building II, Ann Arbor, Michigan 48109 0618, USA
    Mamm Genome 7:268-70. 1996
    ..These assignments are based on the karyotype proposed by Stone and associates (Genome 34, 407, 1991) using high-resolution techniques. In addition, we have assigned the Menkes gene to the X Chr of the dog...
  56. ncbi Mutations in GLUT2, the gene for the liver-type glucose transporter, in patients with Fanconi-Bickel syndrome
    R Santer
    Department of Paediatrics, University of Kiel, Germany uni kiel de
    Nat Genet 17:324-6. 1997
    ..Here we report mutations in the gene encoding the facilitative glucose transporter 2 (GLUT2) in three FBS families, including the original patient described in 1949 by Fanconi and Bickel...
  57. ncbi GLUT2 in pancreatic islets: crucial target molecule in diabetes induced with multiple low doses of streptozotocin in mice
    Z Wang
    Clinical Experimental Department, Diabetes Research Institute, Heinrich Heine University of Dusseldorf, Germany
    Diabetes 47:50-6. 1998
    ..In this study, we report that GLUT2 is a target molecule for MLD-STZ toxicity...
  58. ncbi The loss of GLUT2 expression in the pancreatic beta-cells of diabetic db/db mice is associated with an impaired DNA-binding activity of islet-specific trans-acting factors
    C Bonny
    Department of Internal Medicine B 19 135, University Hospital, CHUV, Lausanne, Switzerland
    Mol Cell Endocrinol 135:59-65. 1997
    b>GLUT2 expression is reduced in the pancreatic beta-cells of several diabetic animals...
  59. ncbi Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic beta cells
    L Sussel
    Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, University of California, San Francisco, CA 94143, USA
    Development 125:2213-21. 1998
    ..1. We propose that Nkx2.2 is required for the final differentiation of pancreatic beta cells, and in its absence, beta cells are trapped in an incompletely differentiated state...
  60. ncbi Maternal hyperglycemia alters glucose transport and utilization in mouse preimplantation embryos
    K H Moley
    Department of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Physiol 275:E38-47. 1998
    ..These findings suggest that, in response to a maternal diabetic state, preimplantation mouse embryos experience a decrease in glucose utilization directly related to a decrease in glucose transport at both the mRNA and protein levels...
  61. ncbi Liver hyperplasia and paradoxical regulation of glycogen metabolism and glucose-sensitive gene expression in GLUT2-null hepatocytes. Further evidence for the existence of a membrane-based glucose release pathway
    R Burcelin
    Institute of Pharmacology and Toxicology, University of Lausanne, 27, Rue du Bugnon, CH 1005 Lausanne, Switzerland
    J Biol Chem 275:10930-6. 2000
    We investigated the impact of GLUT2 gene inactivation on the regulation of hepatic glucose metabolism during the fed to fast transition...
  62. pmc Hepatocyte nuclear factor 3beta (Foxa2) is dispensable for maintaining the differentiated state of the adult hepatocyte
    N J Sund
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6145, USA
    Mol Cell Biol 20:5175-83. 2000
    ..This is the first example of such functional dichotomy for a tissue specification transcription factor...
  63. ncbi Glucose sensing by the hepatoportal sensor is GLUT2-dependent: in vivo analysis in GLUT2-null mice
    R Burcelin
    Institute of Pharmacology and Toxicology, University of Lausanne, Switzerland
    Diabetes 49:1643-8. 2000
    ..In this study, we tested whether GLUT2 plays a role in the portal glucose-sensing system that is similar to its involvement in pancreatic beta-cells...
  64. ncbi The roles of ATF3 in glucose homeostasis. A transgenic mouse model with liver dysfunction and defects in endocrine pancreas
    A E Allen-Jennings
    Department of Molecular and Cellular Biochemistry, Ohio State Biochemistry Program, Ohio State University, Columbus, Ohio 43210, USA
    J Biol Chem 276:29507-14. 2001
    ..Because ATF3 is a stress-inducible gene, these mice may represent a model to investigate the molecular mechanisms for some stress-associated diseases...
  65. ncbi GLUT2 in pancreatic and extra-pancreatic gluco-detection (review)
    B Thorens
    Institute of Pharmacology and Toxicology, University of Lausanne, Switzerland
    Mol Membr Biol 18:265-73. 2001
    ..This signalling mechanism depends on glucose metabolism and requires the presence of specific molecules such as GLUT2, glucokinase and the K(ATP) channel subunits Kir6.2 and SUR1...
  66. ncbi Effect of spontaneous gestational diabetes on fetal and postnatal hepatic insulin resistance in Lepr(db/+) mice
    Hiroshi Yamashita
    Department of Pediatric, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Pediatr Res 53:411-8. 2003
    ....
  67. ncbi Conversion of biliary system to pancreatic tissue in Hes1-deficient mice
    Ryo Sumazaki
    Department of Child Health, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Japan
    Nat Genet 36:83-7. 2004
    ..Thus, biliary epithelium has the potential for pancreatic differentiation and Hes1 determines biliary organogenesis by preventing the pancreatic differentiation program, probably by directly repressing transcription of Neurog3...
  68. ncbi Beta-cell-targeted overexpression of phosphodiesterase 3B in mice causes impaired insulin secretion, glucose intolerance, and deranged islet morphology
    Linda Härndahl
    Departments of Cell and Molecular Biology, Biomedical Center, C11, Land Sweden
    J Biol Chem 279:15214-22. 2004
    ..Furthermore, morphological examinations demonstrated deranged islet cytoarchitecture. In conclusion, these results are consistent with an essential role for PDE3B in cAMP-mediated regulation of insulin release and glucose homeostasis...
  69. ncbi The role of Brn4/Pou3f4 and Pax6 in forming the pancreatic glucagon cell identity
    R Scott Heller
    Department of Developmental Biology, Hagedorn Research Institute, DK 2820 Gentofte, Denmark
    Dev Biol 268:123-34. 2004
    ..2 cells. The pancreatic phenotype of the pax6 mutants can be rescued with a YAC clone containing the human Pax6 gene...
  70. ncbi Orpk mouse model of polycystic kidney disease reveals essential role of primary cilia in pancreatic tissue organization
    David A Cano
    Diabetes Center, Department of Medicine, University of California, San Francisco, CA 94143, USA
    Development 131:3457-67. 2004
    ..Thus, polaris and primary cilia function are required for the maturation and maintenance of proper tissue organization in the pancreas...
  71. ncbi Knock-in of diphteria toxin A chain gene at Ins2 locus: effects on islet development and localization of Ins2 expression in the brain
    Luciane Lamotte
    Institut Cochin, INSERM U567, CNRS UMR 8104, Universite Rene Descartes, Departement Genetique, Developpement et Pathologie Moleculaire, 24 rue du Faubourg Saint Jacques, 75014 Paris, France
    Transgenic Res 13:463-73. 2004
    ..Transcripts for other key beta-cell markers, with the notable exception of Pdx-1, were also found in CP RNAs. These results must revive interest in studies focused on extrapancreatic insulin gene expression...
  72. pmc Mice without the regulator gene Rsc1A1 exhibit increased Na+-D-glucose cotransport in small intestine and develop obesity
    Christina Osswald
    Institute of Anatomy and Cell Biology, Bavarian Julius Maximilians University, Koellikerstrasse 6, 97070 Wurzburg, Germany
    Mol Cell Biol 25:78-87. 2005
    ..At this age, serum leptin was increased, whereas food intake was the same as for wild-type mice. The data suggest that the removal of RS1 leads to leptin-independent up-regulation of food intake, which causes obesity...
  73. pmc Matrix metalloproteinases 2 and 9 are dispensable for pancreatic islet formation and function in vivo
    Sabina E Perez
    Diabetes Center, Department of Medicine, University of California, San Francisco, California, 94143 0573, USA
    Diabetes 54:694-701. 2005
    ..However, islet formation is unaffected in transgenic mice with modified tissue inhibitor of metalloproteinase-1 (TIMP1) levels, suggesting that MMP activity may contribute little to islet morphogenesis in vivo...
  74. ncbi The simultaneous loss of Arx and Pax4 genes promotes a somatostatin-producing cell fate specification at the expense of the alpha- and beta-cell lineages in the mouse endocrine pancreas
    Patrick Collombat
    Max Planck Institute for Biophysical Chemistry, Department of Molecular Cell Biology, Am Fassberg, 37077 Gottingen, Germany
    Development 132:2969-80. 2005
    ..Finally, our data provide evidence that both Arx and Pax4 act as transcriptional repressors that control the expression level of one another, thereby mediating proper endocrine fate allocation...
  75. ncbi Notch/Rbp-j signaling prevents premature endocrine and ductal cell differentiation in the pancreas
    Junji Fujikura
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
    Cell Metab 3:59-65. 2006
    ..Thus, our analyses indicate that Notch/Rbp-j signaling prevents premature differentiation of pancreatic progenitor cells into endocrine and ductal cells during early development of the pancreas...
  76. pmc A switch from MafB to MafA expression accompanies differentiation to pancreatic beta-cells
    Wataru Nishimura
    Section of Islet Transplantation and Cell Biology, Joslin Diabetes Center, Boston, MA 02215, USA
    Dev Biol 293:526-39. 2006
    ..Thus, this redundancy in the function and expression of the large-Maf factors may explain the normal islet morphology observed in the MafA knockout mice at birth...
  77. pmc Ablation of the glucagon receptor gene increases fetal lethality and produces alterations in islet development and maturation
    Patricia M Vuguin
    Division of Pediatric Endocrinology, Children s Hospital at Montefiore Medical Center, 111 East 210th Street, Bronx, New York 10476, USA
    Endocrinology 147:3995-4006. 2006
    ..These findings suggest that GLU participates in a feedback loop that regulates the proportion of the different endocrine cell types in islets, the number of islets per pancreas, and development of the mature alpha-cell phenotype...
  78. ncbi PERK EIF2AK3 control of pancreatic beta cell differentiation and proliferation is required for postnatal glucose homeostasis
    Wei Zhang
    Department of Biology, Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Cell Metab 4:491-7. 2006
    ....
  79. pmc Nkx2.2-repressor activity is sufficient to specify alpha-cells and a small number of beta-cells in the pancreatic islet
    Michelle J Doyle
    Program in Molecular Biology, University of Colorado at Denver Health Sciences Center, Aurora, CO 80045, USA
    Development 134:515-23. 2007
    ..insulin-positive cells that do form in the rescued mice do not express the mature beta-cell markers MafA or Glut2 (Slc2a2), suggesting that additional activator functions of Nkx2.2 are required for beta-cell maturation...
  80. pmc Loss of sugar detection by GLUT2 affects glucose homeostasis in mice
    Emilie Stolarczyk
    Centre de Recherche des Cordeliers, Universite Pierre et Marie Curie PARIS6, UMR S 872, Paris, France
    PLoS ONE 2:e1288. 2007
    ..Here, we studied the detection of extracellular glucose concentrations in vivo by invalidating the transduction pathway downstream from the transporter-detector GLUT2 and measured the physiological impact of this pathway.
  81. doi PTP1B deficiency increases glucose uptake in neonatal hepatocytes: involvement of IRA/GLUT2 complexes
    Agueda Gonzalez-Rodriguez
    Instituto de Investigaciones Biomedicas Alberto Sols, C Arturo Pérez Duperier 4, 28029 Madrid, Spain
    Am J Physiol Gastrointest Liver Physiol 295:G338-47. 2008
    ..By contrast, the glucose transporter GLUT2 was upregulated at the protein level in neonatal hepatocytes and livers from PTP1B-deficient neonates...
  82. doi Molecular identification and functional characterization of the vitamin C transporters expressed by Sertoli cells
    Constanza Angulo
    Instituto de Bioquimica, Facultad de Ciencias, Universidad Austral de Chile, Valdivia, Chile
    J Cell Physiol 217:708-16. 2008
    ..and 3-methylglucose (OMG) transport by 42GPA9 Sertoli cells correspond to facilitative hexose transporters GLUT1, GLUT2 and GLUT3 expressed in these cells...
  83. pmc A dosage-dependent requirement for Sox9 in pancreatic endocrine cell formation
    Philip A Seymour
    Department of Developmental and Cell Biology, University of California, Irvine, Irvine, CA 92697 2300, USA
    Dev Biol 323:19-30. 2008
    ..Our findings therefore suggest that defective endocrine specification might underlie the pancreatic phenotype of individuals with CD...
  84. pmc Hexose transporter expression and function in mouse small intestine: role of diurnal rhythm
    Javairiah Fatima
    Gastroenterology Research Unit GU 1001, Department of Surgery, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    J Gastrointest Surg 13:634-41. 2009
    ..Expression and function of hexose transporters vary diurnally in rat small intestine; however, this subject remains unexplored in mice...
  85. pmc Transcription factor Glis3, a novel critical player in the regulation of pancreatic beta-cell development and insulin gene expression
    Hong Soon Kang
    Cell Biology Section, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, 111 T W Alexander Drive, Research Triangle Park, NC 27709, USA
    Mol Cell Biol 29:6366-79. 2009
    ..In addition, we provide evidence that Glis3 regulates insulin gene expression through two Glis-binding sites in its proximal promoter, indicating that Glis3 also regulates beta-cell function...
  86. pmc Positive regulatory control loop between gut leptin and intestinal GLUT2/GLUT5 transporters links to hepatic metabolic functions in rodents
    Yassine Sakar
    INSERM, U773, Centre de recherche Biomedicale Bichat Beaujon, UFR de Médecine Paris 7 Denis Diderot, IFR02 Claude Bernard, Paris, France
    PLoS ONE 4:e7935. 2009
    ..In this study, we determine the effects of luminal leptin on activity/expression of GLUT2 and GLUT5 transporters in response to sugars intake and analyse their physiological consequences.
  87. pmc Neurog3 gene dosage regulates allocation of endocrine and exocrine cell fates in the developing mouse pancreas
    Sui Wang
    Program in Developmental Biology and Department of Cell and Developmental Biology, Center for Stem Cell Biology, Vanderbilt University Medical Center, 465 21st Avenue South, Rm 4128, Vanderbilt Medical Center, Nashville, TN 37232, USA
    Dev Biol 339:26-37. 2010
    ..The control of Neurog3+ cell number and the Neurog3 threshold-dependent endocrine differentiation mechanism combine to select a specific proportion of pancreatic progenitor cells to adopt the islet cell fate...
  88. doi Glut2-dependent glucose-sensing controls thermoregulation by enhancing the leptin sensitivity of NPY and POMC neurons
    Lourdes Mounien
    Department of Physiology and Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland
    FASEB J 24:1747-58. 2010
    ..and leptin sensitivity of hypothalamic arcuate neurons in mice with inactivation of glucose transporter type 2 (Glut2)-dependent glucose sensing...
  89. pmc Loss of enteroendocrine cells in mice alters lipid absorption and glucose homeostasis and impairs postnatal survival
    Georg Mellitzer
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, INSERM U964, CNRS UMR 7104, Universite de Strasbourg, Illkirch, France
    J Clin Invest 120:1708-21. 2010
    ..Our data help unravel the role of enteroendocrine cells and hormones in lipid absorption and maintenance of the intestinal epithelium...
  90. doi Genetic evidence of the programming of beta cell mass and function by glucocorticoids in mice
    B Valtat
    INSERM UMR S 872, Centre de Recherche des Cordeliers, 15 rue de l Ecole de Medecine, 75006 Paris, France
    Diabetologia 54:350-9. 2011
    ..Our aim was to further dissect the role of glucocorticoids on beta cell development and function in mice...
  91. pmc Influence and timing of arrival of murine neural crest on pancreatic beta cell development and maturation
    Jennifer L Plank
    Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Dev Biol 349:321-30. 2011
    ..that without neural crest, there was a reduction in the percentage of insulin-positive cells that co-expressed Glut2 and Pdx1 compared to controls...
  92. pmc Rictor/mTORC2 is essential for maintaining a balance between beta-cell proliferation and cell size
    Yanyun Gu
    Center for Stem Cell Biology, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    Diabetes 60:827-37. 2011
    ..We examined the role of Rictor/mammalian target of rapamycin complex 2 (mTORC2), a key component of the phosphotidylinositol-3-kinase (PI3K)/mTORC2/AKT signaling pathway, in regulating both β-cell mass and function...
  93. pmc The thyroid hormone-inactivating type III deiodinase is expressed in mouse and human beta-cells and its targeted inactivation impairs insulin secretion
    Mayrin C Medina
    Division of Endocrinology, Diabetes, and Metabolism, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    Endocrinology 152:3717-27. 2011
    ..An analogous role is likely in humans, given the similar D3 expression pattern...
  94. ncbi Glucose transporter expression and functional role of hexokinase in insulin biosynthesis in mouse beta TC3 cells
    S Nagamatsu
    Department of Biochemistry, Kyorin University School of Medicine, Tokyo, Japan
    Am J Physiol 269:C480-6. 1995
    ....
  95. ncbi Novel mouse microsatellites: primer sequences and chromosomal location
    T Suda
    First Department of Biochemistry, Niigata University School of Medicine, Japan
    DNA Res 1:169-74. 1994
    ..The microsatellites were distributed to most chromosomes except for chromosomes 16 and 19. These novel markers with defined locations are useful in linkage and genome mapping studies...
  96. pmc Endotoxin-induced enhancement of glucose influx into murine peritoneal macrophages via GLUT1
    M Fukuzumi
    Department of Microbiology, Ehime University School of Medicine, Japan
    Infect Immun 64:108-12. 1996
    ..These results suggest that macrophage responses to LPS are supported by a rapid and sustained glucose influx via GLUT1 and that this is a participating factor in the development of systemic hypoglycemia when endotoxemia is prolonged...
  97. ncbi Is GLUT2 required for glucose sensing?
    F C Schuit
    Department of Biochemistry, Vrije Universiteit Brussel, Belgium
    Diabetologia 40:104-11. 1997
  98. ncbi Regeneration of pancreatic beta cells from intra-islet precursor cells in an experimental model of diabetes
    Y Guz
    Department of Anatomy and Cell Biology, State University of New York, Health Science Center at Brooklyn, Brooklyn, New York 11203, USA
    Endocrinology 142:4956-68. 2001
    ..We conclude that beta cell neogenesis occurred in adult islets and that the outcome of this process was regulated by the insulin-mediated normalization of circulating blood glucose levels...
  99. ncbi Distinct expression patterns of splicing isoforms of mNumb in the endocrine lineage of developing pancreas
    Tetsu Yoshida
    Department of Physiology Keio University School of Medicine 35 Shinanomachi, Shinjuku ku Tokyo 160 8582, Japan
    Differentiation 71:486-95. 2003
    ..In addition, islet cells, which are produced from ductal tissue, were immunostained by the anti-panNb antibody. Our present results will contribute to the understanding of the mechanisms of islet development from ductal tissue...

Research Grants6

  1. FUNCTION OF A GROWTH INDUCED GENE IN LIVER REGENERATION
    KLAUS KAESTNER; Fiscal Year: 2003
    ....
  2. Expression profiling of human islets
    KLAUS KAESTNER; Fiscal Year: 2006
    ....
  3. Nutrition, Early Development and Glucose Metabolism
    Patricia Vuguin; Fiscal Year: 2007
    ..abstract_text> ..
  4. Development of C57BL/6 ES cell technology for high thoughput use.
    KLAUS KAESTNER; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  5. FUNCTIONAL GENOMICS OF THE BETA-CELL
    KLAUS KAESTNER; Fiscal Year: 2007
    ..The new resources generated through this project will be made available to the NIDDK-funded biotechnology centers and the diabetes research community at large. ..
  6. Liver Biology, Development and Disease
    KLAUS KAESTNER; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..