Slc22a6

Summary

Gene Symbol: Slc22a6
Description: solute carrier family 22 (organic anion transporter), member 6
Alias: NKT, Oat1, Orctl1, mOat1, solute carrier family 22 member 6, kidney-specific transport protein, mNKT, mROAT1, novel kidney transcript, organic anion transporter 1, organic cationic transporter-like 1, renal organic anion transporter 1
Species: mouse

Top Publications

  1. ncbi Decreased renal organic anion secretion and plasma accumulation of endogenous organic anions in OAT1 knock-out mice
    Satish A Eraly
    Department of Medicine, University of California San Diego, La Jolla, California 92093, USA
    J Biol Chem 281:5072-83. 2006
  2. pmc Multi-level analysis of organic anion transporters 1, 3, and 6 reveals major differences in structural determinants of antiviral discrimination
    David M Truong
    Department of Pediatrics, University of California at San Diego, La Jolla, CA 92093, USA
    J Biol Chem 283:8654-63. 2008
  3. pmc Arsenic and Mercury Containing Traditional Chinese Medicine (Realgar and Cinnabar) Strongly Inhibit Organic Anion Transporters, Oat1 and Oat3, In Vivo in Mice
    Wen Hao Yu
    Department of Pharmacology, Guangzhou University of Chinese Medicine, Guangzhou 510006, China
    Biomed Res Int 2015:863971. 2015
  4. doi Organic Anion Transporter 1 Deficiency Accelerates Learning and Memory Impairment in tg2576 Mice by Damaging Dendritic Spine Morphology and Activity
    Xinlin Wu
    Department of Traditional Chinese Medicine, The First Affiliated Hospital, Sun Yat Sen University, 58 Second Zhongshan Road, Guangzhou, 510080, China
    J Mol Neurosci 56:730-8. 2015
  5. doi The anthraquinone drug rhein potently interferes with organic anion transporter-mediated renal elimination
    Li Wang
    Department of Pharmaceutics, Virginia Commonwealth University, 410 N 12th Street, Richmond, VA 23298 0533, USA Electronic address
    Biochem Pharmacol 86:991-6. 2013
  6. pmc Sex-dependent expression of Oat3 (Slc22a8) and Oat1 (Slc22a6) proteins in murine kidneys
    Davorka Breljak
    Molecular Toxicology, Institute for Medical Research and Occupational Health, Ksaverska cesta 2, HR 10000 Zagreb, Croatia
    Am J Physiol Renal Physiol 304:F1114-26. 2013
  7. ncbi Role of glycosylation in the organic anion transporter OAT1
    Kunihiko Tanaka
    Department of Pharmaceutics, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA
    J Biol Chem 279:14961-6. 2004
  8. pmc Organic anion transport pathways in antiviral handling in choroid plexus in Oat1 (Slc22a6) and Oat3 (Slc22a8) deficient tissue
    Megha A Nagle
    Department of Pediatrics, UCSD, La Jolla, CA 92093, United States
    Neurosci Lett 534:133-8. 2013
  9. pmc A role for the organic anion transporter OAT3 in renal creatinine secretion in mice
    Volker Vallon
    Depts of Medicine and Pharmacology, Univ of California San Diego and VASDHCS, 3350 La Jolla Village Dr 9151 San Diego, CA 92161, USA
    Am J Physiol Renal Physiol 302:F1293-9. 2012
  10. doi Liver X receptor activation downregulates organic anion transporter 1 (OAT1) in the renal proximal tubule
    Suticha Kittayaruksakul
    Dept of Physiology, Mahidol Univ, Bangkok, Thailand
    Am J Physiol Renal Physiol 302:F552-60. 2012

Scientific Experts

  • Li Wang
  • Volker Vallon
  • Davorka Breljak
  • James J Kohler
  • Andrew Bahn
  • Sanjay K Nigam
  • Satish A Eraly
  • Megha A Nagle
  • David M Truong
  • Gregory Kaler
  • Wei Wu
  • William R Wikoff
  • Sun Young Ahn
  • Kunihiko Tanaka
  • Xinlin Wu
  • Wen Hao Yu
  • Julio C Monte
  • Suticha Kittayaruksakul
  • BETHZAIDA ASTORGA
  • Adriana M Torres
  • Ankur V Dnyanmote
  • Jin Sun Hwang
  • Kleber S Parreira
  • Scott A Barros
  • Takami Saji
  • Akash Khandelwal
  • Peter W Swaan
  • Bruce A Barshop
  • Jon A Gangoiti
  • Timo Rieg
  • Douglas H Sweet
  • Megha Nagle
  • Takashi Sekine
  • Wei Jiang
  • S K Nigam
  • Fanfan Zhou
  • Guofeng You
  • Geri L Youngblood
  • Jennifer A Floyd
  • Mei Lin
  • Yansheng Mian
  • Baoguo Sun
  • Jin Feng Qi
  • Yong Hui Wang
  • Jianqing Zhang
  • Chen Sun
  • Birong Liang
  • Shijun Zhang
  • Hongbo Xie
  • Na Zhang
  • Houming Zhou
  • Heng Liu
  • Nithi Asavapanumas
  • Chatchai Muanprasat
  • D H Sweet
  • Varanuj Chatsudthipong
  • Sunhapas Soodvilai
  • Stephen H Wright
  • Mark Morales
  • Igor F Tsigelny
  • Kevin T Bush
  • Theresa M Wunz
  • Ryan M Pelis
  • Valentina L Kouznetsova
  • T B Bartnikas
  • Eun Young Park
  • Wan Young Kim
  • Jin Kim
  • A Pavlova
  • Chul Woo Yang
  • Ramsey Walden
  • John B Pritchard
  • Chutima Srimaroeng
  • Igor Tsigelny
  • Neetu Dembla-Rajpal
  • Lars Geffers
  • Yvette Cnops
  • Olivier Devuyst
  • Jennifer L Perry
  • Huguette Debaix
  • Hiroyuki Kusuhara
  • Ryota Kikuchi
  • Insook Kim
  • Frank J Gonzalez
  • Yuichi Sugiyama
  • K T Bush
  • Gary Siuzdak
  • D R Beier
  • Kerstin Richter
  • Jeffrey M Long

Detail Information

Publications33

  1. ncbi Decreased renal organic anion secretion and plasma accumulation of endogenous organic anions in OAT1 knock-out mice
    Satish A Eraly
    Department of Medicine, University of California San Diego, La Jolla, California 92093, USA
    J Biol Chem 281:5072-83. 2006
    ..b>Organic anion transporter 1 (OAT1), originally identified as NKT (Lopez-Nieto, C. E., You, G., Bush, K. T., Barros, E. J. G...
  2. pmc Multi-level analysis of organic anion transporters 1, 3, and 6 reveals major differences in structural determinants of antiviral discrimination
    David M Truong
    Department of Pediatrics, University of California at San Diego, La Jolla, CA 92093, USA
    J Biol Chem 283:8654-63. 2008
    ..Of nine common antiviral drugs assessed in oocytes, many manifested higher affinity for SLC22a6 (mOat1), originally identified as NKT (e.g...
  3. pmc Arsenic and Mercury Containing Traditional Chinese Medicine (Realgar and Cinnabar) Strongly Inhibit Organic Anion Transporters, Oat1 and Oat3, In Vivo in Mice
    Wen Hao Yu
    Department of Pharmacology, Guangzhou University of Chinese Medicine, Guangzhou 510006, China
    Biomed Res Int 2015:863971. 2015
    ..The aim of this study was to investigate whether these samples affect organic anion transporters, Oat1 and Oat3, in vivo in mice kidney. Mice (n = 10) were orally treated with investigational samples...
  4. doi Organic Anion Transporter 1 Deficiency Accelerates Learning and Memory Impairment in tg2576 Mice by Damaging Dendritic Spine Morphology and Activity
    Xinlin Wu
    Department of Traditional Chinese Medicine, The First Affiliated Hospital, Sun Yat Sen University, 58 Second Zhongshan Road, Guangzhou, 510080, China
    J Mol Neurosci 56:730-8. 2015
    To investigate whether and how organic anion transporter 1 (OAT1) is involved in the process of Alzheimer's disease (AD), we crossbred OAT1 knockout mice with tg2576, the widely used AD model mice...
  5. doi The anthraquinone drug rhein potently interferes with organic anion transporter-mediated renal elimination
    Li Wang
    Department of Pharmaceutics, Virginia Commonwealth University, 410 N 12th Street, Richmond, VA 23298 0533, USA Electronic address
    Biochem Pharmacol 86:991-6. 2013
    ..Therefore, the inhibitory effect of rhein on human (h) OAT1, hOAT3, hOAT4, and murine (m) Oat1 and mOat3 was examined in heterologous cell lines stably expressing each ..
  6. pmc Sex-dependent expression of Oat3 (Slc22a8) and Oat1 (Slc22a6) proteins in murine kidneys
    Davorka Breljak
    Molecular Toxicology, Institute for Medical Research and Occupational Health, Ksaverska cesta 2, HR 10000 Zagreb, Croatia
    Am J Physiol Renal Physiol 304:F1114-26. 2013
    ..Moreover, the sex-dependent expression of mOat3, and of the functionally similar transporter mOat1 (Slc22a6), in the mouse kidney has been studied at mRNA level, whereas their protein expression is poorly documented...
  7. ncbi Role of glycosylation in the organic anion transporter OAT1
    Kunihiko Tanaka
    Department of Pharmaceutics, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA
    J Biol Chem 279:14961-6. 2004
    ..significantly inhibited organic anion transport in COS-7 cells expressing a mouse organic anion transporter (mOAT1), suggesting an important role of glycosylation in mOAT1 function...
  8. pmc Organic anion transport pathways in antiviral handling in choroid plexus in Oat1 (Slc22a6) and Oat3 (Slc22a8) deficient tissue
    Megha A Nagle
    Department of Pediatrics, UCSD, La Jolla, CA 92093, United States
    Neurosci Lett 534:133-8. 2013
    ..Here, high CP expression was noted for the organic anion transporters, Oat1 (SLC22A6 or NKT) and Oat3 (SLC22A8) which are also the principal Oats in the renal proximal tubule, as well as SLC22A17, ..
  9. pmc A role for the organic anion transporter OAT3 in renal creatinine secretion in mice
    Volker Vallon
    Depts of Medicine and Pharmacology, Univ of California San Diego and VASDHCS, 3350 La Jolla Village Dr 9151 San Diego, CA 92161, USA
    Am J Physiol Renal Physiol 302:F1293-9. 2012
    ..Here, we demonstrate specific uptake of creatinine into mouse mOat1- and mOat3-microinjected Xenopus laevis oocytes at a concentration of 10 μM (i.e...
  10. doi Liver X receptor activation downregulates organic anion transporter 1 (OAT1) in the renal proximal tubule
    Suticha Kittayaruksakul
    Dept of Physiology, Mahidol Univ, Bangkok, Thailand
    Am J Physiol Renal Physiol 302:F552-60. 2012
    ..In this study, we investigated the role of LXRs in the regulation of human organic anion transporter 1 (hOAT1), a major transporter localized in the basolateral membrane of the renal proximal tubule...
  11. pmc Differences in the substrate binding regions of renal organic anion transporters 1 (OAT1) and 3 (OAT3)
    BETHZAIDA ASTORGA
    Dept of Pharmacology, College of Medicine, University of Arizona, Tucson, USA
    Am J Physiol Renal Physiol 301:F378-86. 2011
    This study examined the selectivity of organic anion transporters OAT1 and OAT3 for structural congeners of the heavy metal chelator 2,3-dimercapto-1-propanesulfonic acid (DMPS)...
  12. pmc Interaction of organic cations with organic anion transporters
    Sun Young Ahn
    Department of Pediatrics, School of Medicine, University of California, San Diego, La Jolla, California 92093, USA
    J Biol Chem 284:31422-30. 2009
    ..We now show that mouse Oat1 (mOat1) and mOat3 and, to a lesser degree, mOat6 bind a number of "prototypical" Oct substrates, including 1-methyl-4-..
  13. pmc Multiple organic anion transporters contribute to net renal excretion of uric acid
    Satish A Eraly
    Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    Physiol Genomics 33:180-92. 2008
    ..null for RST, the murine ortholog of URAT1, as well as in those null for the related organic anion transporters Oat1 and Oat3...
  14. ncbi Expression of OAT1 and OAT3 in differentiating proximal tubules of the mouse kidney
    Jin Sun Hwang
    Department of Anatomy, Cell Death Disease Research Center, College of Medicine, The Catholic University of Korea, Seoul, Korea
    Histol Histopathol 25:33-44. 2010
    b>Organic anion transporter 1 (OAT1) and OAT3 in the proximal tubules (PT) of the kidney play important roles in the elimination of harmful endogenous compounds and xenobiotics from the body...
  15. pmc Analysis of three-dimensional systems for developing and mature kidneys clarifies the role of OAT1 and OAT3 in antiviral handling
    Megha A Nagle
    Department of Pediatrics, University of California San Diego, La Jolla, California 92093, USA
    J Biol Chem 286:243-51. 2011
    The organic anion transporters OAT1 (SLC22A6, originally identified by us as NKT) and OAT3 (SLC22A8) are critical for handling many toxins, metabolites, and drugs, including antivirals (Truong, D. M., Kaler, G., Khandelwal, A., Swaan, P...
  16. pmc Tenofovir renal proximal tubular toxicity is regulated by OAT1 and MRP4 transporters
    James J Kohler
    Department of Pathology, Emory University School of Medicine, Atlanta, GA 30033, USA
    Lab Invest 91:852-8. 2011
    ..In this study, the role(s) of organic anion transporter type 1 (OAT1) and multidrug-resistant protein type 4 (MRP4) in transport and regulation of tenofovir in proximal tubules were ..
  17. pmc Untargeted metabolomics identifies enterobiome metabolites and putative uremic toxins as substrates of organic anion transporter 1 (Oat1)
    William R Wikoff
    Genome Center, University of California Davis, CA, USA
    J Proteome Res 10:2842-51. 2011
    Untargeted metabolomics on the plasma and urine from wild-type and organic anion transporter-1 (Oat1/Slc22a6) knockout mice identified a number of physiologically important metabolites, including several not previously linked to Oat1-..
  18. pmc Deletion of multispecific organic anion transporter Oat1/Slc22a6 protects against mercury-induced kidney injury
    Adriana M Torres
    Farmacologia, Facultad de Ciencias Bioquimicas y Farmaceuticas, Universidad Nacional de Rosario, Consejo Nacional de Investigaciones Cientificas y Tecnicas, 2000 Rosario, Argentina
    J Biol Chem 286:26391-5. 2011
    ..Here, we investigated the in vivo role of Oat1 (organic anion transporter 1; originally NKT (Lopez-Nieto, C. E., You, G., Bush, K. T., Barros, E. J., Beier, D. R., and Nigam, S. K...
  19. pmc Expression patterns of the aquaporin gene family during renal development: influence of genetic variability
    Kleber S Parreira
    Division of Nephrology, Université Catholique de Louvain Medical School, 10 Avenue Hippocrate, 1200, Brussels, Belgium
    Pflugers Arch 458:745-59. 2009
    ..increase to adult levels, similar to the mRNA pattern observed for proximal tubule markers (Megalin, NaPi-IIa, OAT1) and reflecting the continuous increase in renal cortical structures during development...
  20. pmc Activation of protein kinase Czeta increases OAT1 (SLC22A6)- and OAT3 (SLC22A8)-mediated transport
    Scott A Barros
    Laboratory of Pharmacology, NIEHS, NIH, Research Triangle Park, NC 27709, USA
    J Biol Chem 284:2672-9. 2009
    ..Increased ES transport was not observed in renal slices from OAT3-null mice. Transport of the shared OAT1/OAT3 substrate, rho-aminohippurate, behaved similarly, except that stimulation was reduced, not abolished, in the ..
  21. ncbi Molecular cloning and characterization of NKT, a gene product related to the organic cation transporter family that is almost exclusively expressed in the kidney
    C E Lopez-Nieto
    Renal and Genetics Divisions, Department of Medicine, Harvard Medical School and Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Biol Chem 272:6471-8. 1997
    We have identified a gene product (NKT) encoding an apparently novel transcript that appears to be related to the organic ion transporter family and is expressed almost exclusively in the kidney...
  22. ncbi Transcriptional regulation of human and mouse organic anion transporter 1 by hepatocyte nuclear factor 1 alpha/beta
    Takami Saji
    Department of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, USA
    J Pharmacol Exp Ther 324:784-90. 2008
    b>Organic anion transporter 1 (OAT1/SLC22A6) is predominantly expressed in the proximal tubules of the kidney...
  23. pmc Structural variation governs substrate specificity for organic anion transporter (OAT) homologs. Potential remote sensing by OAT family members
    Gregory Kaler
    Department of Medicine, University of California, San Diego, La Jolla, California 92093, USA
    J Biol Chem 282:23841-53. 2007
    ..function of olfactory organic anion transporter, Oat6, in comparison with the more broadly expressed transporter, Oat1 (first identified as NKT)...
  24. ncbi Molecular physiology of renal organic anion transporters
    Takashi Sekine
    Kyorin University School of Medicine, Department of Pharmacology and Toxicology, 6 20 2 Shinkawa, Mitaka shi, Tokyo 181 8611, Japan
    Am J Physiol Renal Physiol 290:F251-61. 2006
    ..We will also discuss the physiological roles of each organic anion transporter in the light of the transepithelial transport of organic anions in the kidneys...
  25. pmc IRIP, a new ischemia/reperfusion-inducible protein that participates in the regulation of transporter activity
    Wei Jiang
    Department of Biochemistry, Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, NJ 08854, USA
    Mol Cell Biol 25:6496-508. 2005
    ..The activities of exogenous organic cation transporters (OCT2 and OCT3), organic anion transporter (OAT1), and monoamine transporters were also inhibited by IRIP...
  26. ncbi Murine renal organic anion transporters mOAT1 and mOAT3 facilitate the transport of neuroactive tryptophan metabolites
    Andrew Bahn
    Zentrum für Physiologie und Pathophysiologie, Abt Vegetative Physiologie und Pathophysiologie, Universitat Gottingen, Humboldtallee 23, D 37073 Gottingen, Germany
    Am J Physiol Cell Physiol 289:C1075-84. 2005
    ..Half-maximal inhibition of mOAT1 occurred at 34 muM KYNA and 15 muM XA, and it occurred at 8 muM KYNA and 11.5 muM XA for mOAT3...
  27. ncbi Identification of a novel murine organic anion transporter family member, OAT6, expressed in olfactory mucosa
    Julio C Monte
    Department of Medicine, University of California, San Diego, La Jolla, CA 92093 0693, USA
    Biochem Biophys Res Commun 323:429-36. 2004
    ..Sequence comparisons and intron phasing analysis indicated that OAT6 is closely related to OAT1 and OAT3...
  28. ncbi Identification and functional assessment of the novel murine organic anion transporter Oat5 (Slc22a19) expressed in kidney
    Geri L Youngblood
    Department of Pharmaceutical Sciences, Medical University of South Carolina, Charleston, SC 29425, USA
    Am J Physiol Renal Physiol 287:F236-44. 2004
    ..Slc22a19 was localized to mouse chromosome 19 near the genes encoding Oat1 (Slc22a6) and Oat3 (Slc22a8)...
  29. pmc Cysteine residues in the organic anion transporter mOAT1
    Kunihiko Tanaka
    Department of Pharmaceutical Science, Rutgers, The State University of New Jersey, 160 Frelinghuysen Road, Piscataway, NJ 08854, USA
    Biochem J 380:283-7. 2004
    Mouse organic anion transporter 1 (mOAT1) belongs to a family of organic anion transporters, which play critical roles in the body disposition of clinically important drugs, including anti-HIV therapeutics, anti-tumour drugs, antibiotics,..
  30. pmc A natural allele of Nxf1 suppresses retrovirus insertional mutations
    Jennifer A Floyd
    Biomedical Sciences Graduate Program, UCSD School of Medicine, 9500 Gilman Drive, La Jolla, California 92093 0644, USA
    Nat Genet 35:221-8. 2003
    ..A congenic Mvb1(CAST) allele is a useful tool for modifying gene expression from existing mutations and could be used to manipulate engineered mutations containing retroviral elements...
  31. ncbi The organic anion transporter family: from physiology to ontogeny and the clinic
    D H Sweet
    Department of Pediatrics, Division of Nephrology Hypertension, University of California, San Diego, La Jolla, California 92093, USA
    Am J Physiol Renal Physiol 281:F197-205. 2001
    ..A similar spatiotemporal pattern of mRNA expression of the OATs (OAT1-4) during kidney development suggests that OAT genes may be useful in understanding the mechanisms of proximal ..
  32. ncbi Chromosomal localization of CCS, the copper chaperone for Cu/Zn superoxide dismutase
    T B Bartnikas
    Edward Mallinckrodt Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri, USA
    Mamm Genome 11:409-11. 2000
  33. ncbi Developmentally regulated expression of organic ion transporters NKT (OAT1), OCT1, NLT (OAT2), and Roct
    A Pavlova
    Renal, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Am J Physiol Renal Physiol 278:F635-43. 2000
    ..When we initially identified NKT, also known as OAT1, the first member of the organic anion transporter (OAT) family (Lopez-Nieto CE, You G, Bush KT, Barros EJ, Beier ..