Skap1

Summary

Gene Symbol: Skap1
Description: src family associated phosphoprotein 1
Alias: 1700091G21Rik, Scap1, Skap-55, src kinase-associated phosphoprotein 1, ortholog of human src family associated phosphoprotein 1 SCAP1
Species: mouse

Top Publications

  1. pmc An essential role for SKAP-55 in LFA-1 clustering on T cells that cannot be substituted by SKAP-55R
    Eun Kyeong Jo
    Molecular Immunology Section, Department of Immunology, Faculty of Medicine, Imperial College London, Hammersmith Hospital, London W12 ONN, England, UK
    J Exp Med 201:1733-9. 2005
  2. pmc RIAM links the ADAP/SKAP-55 signaling module to Rap1, facilitating T-cell-receptor-mediated integrin activation
    Gael Menasche
    Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, 415 BRBII III, 421 Curie Blvd, Philadelphia, PA 19104 6160, USA
    Mol Cell Biol 27:4070-81. 2007
  3. pmc Functional defects of SKAP-55-deficient T cells identify a regulatory role for the adaptor in LFA-1 adhesion
    Hongyan Wang
    Department of Pathology, Cambridge University, Tennis Court Road, Cambridge, UK
    Mol Cell Biol 27:6863-75. 2007
  4. pmc Adaptor SKAP-55 binds p21 activating exchange factor RasGRP1 and negatively regulates the p21-ERK pathway in T-cells
    Helga Schneider
    Cell Signalling Section, Department of Pathology, University of Cambridge, Cambridge, United Kingdom
    PLoS ONE 3:e1718. 2008
  5. pmc Regulation of the Src kinase-associated phosphoprotein 55 homologue by the protein tyrosine phosphatase PTP-PEST in the control of cell motility
    Emily Ayoub
    Goodman Cancer Research Centre and Department of Biochemistry, McGill University, Montreal, Quebec H3A 1A3, Canada
    J Biol Chem 288:25739-48. 2013
  6. pmc ADAP and SKAP55 deficiency suppresses PD-1 expression in CD8+ cytotoxic T lymphocytes for enhanced anti-tumor immunotherapy
    Chunyang Li
    Key Laboratory of Systems Biology, Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences, Shanghai, China
    EMBO Mol Med 7:754-69. 2015
  7. pmc SKAP1 is dispensable for chemokine-induced migration of primary T-cells
    Hongyan Wang
    Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK
    Immunol Lett 128:148-53. 2010
  8. pmc T cell receptor "inside-out" pathway via signaling module SKAP1-RapL regulates T cell motility and interactions in lymph nodes
    Monika Raab
    Cell Signaling Section, Department of Pathology, Tennis Court Road, University of Cambridge, Cambridge UK, CB2 1Q
    Immunity 32:541-56. 2010
  9. pmc HPK1 associates with SKAP-HOM to negatively regulate Rap1-mediated B-lymphocyte adhesion
    Sebastian Königsberger
    Department of Molecular Biology, University of Salzburg, Salzburg, Austria
    PLoS ONE 5:. 2010
  10. pmc The pleckstrin homology domain in the SKAP55 adapter protein defines the ability of the adapter protein ADAP to regulate integrin function and NF-kappaB activation
    Brandon J Burbach
    Department of Laboratory Medicine and Pathology, Center for Immunology, Masonic Cancer Center, University of Minnesota Medical School, Minneapolis, MN 55414, USA
    J Immunol 186:6227-37. 2011

Scientific Experts

  • Brandon J Burbach
  • Hongyan Wang
  • Christopher E Rudd
  • Monika Raab
  • Yuning Lu
  • Chunyang Li
  • Emily Ayoub
  • Bin Wei
  • Sebastian Königsberger
  • Xin Smith
  • Zhonglin Wu
  • Klaus Strebhardt
  • Helga Schneider
  • Matt Lovatt
  • Gael Menasche
  • Eun Kyeong Jo
  • Chun Sheng
  • Jun Xiao
  • Fei Teng
  • Shengjie Xue
  • Shaozhuo Jiao
  • Weiyun Li
  • Chi Zhang
  • Qibin Leng
  • Andreas Bikfalvi
  • Maxime Halle
  • Anita Hall
  • Geraldine Miquel
  • Adam M Scott
  • Melanie J Chagnon
  • Michel L Tremblay
  • Masaharu Noda
  • John E Ladbury
  • Irene Patzak
  • Gernot Achatz
  • Friedemann Kiefer
  • Doris Peckl-Schmid
  • Nadja Zaborsky
  • Braudel Maqueira-Iglesias
  • Elke Valk
  • Stefanie Kliche
  • Theresia E B Stradal
  • Gary Koretzky
  • Emily J H Chen
  • Burkhart Schraven
  • Hebin Liu

Detail Information

Publications10

  1. pmc An essential role for SKAP-55 in LFA-1 clustering on T cells that cannot be substituted by SKAP-55R
    Eun Kyeong Jo
    Molecular Immunology Section, Department of Immunology, Faculty of Medicine, Imperial College London, Hammersmith Hospital, London W12 ONN, England, UK
    J Exp Med 201:1733-9. 2005
    ..Our findings therefore indicate that SKAP-55, unlike SKAP-55R, is specifically tailored as an essential component of the inside-out signaling events that couple the TCR to LFA-1 clustering and T cell-APC conjugation...
  2. pmc RIAM links the ADAP/SKAP-55 signaling module to Rap1, facilitating T-cell-receptor-mediated integrin activation
    Gael Menasche
    Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, 415 BRBII III, 421 Curie Blvd, Philadelphia, PA 19104 6160, USA
    Mol Cell Biol 27:4070-81. 2007
    ..These results describe for the first time a link between ADAP/SKAP-55 and the Rap1/RIAM complex and provide a potential new mechanism for TCR-mediated integrin activation...
  3. pmc Functional defects of SKAP-55-deficient T cells identify a regulatory role for the adaptor in LFA-1 adhesion
    Hongyan Wang
    Department of Pathology, Cambridge University, Tennis Court Road, Cambridge, UK
    Mol Cell Biol 27:6863-75. 2007
    ..Our findings identify a clear effector role for SKAP-55 in LFA-1 adhesion in peripheral T cells and demonstrate that dependency on SKAP-55 and ADAP differs among T cells and differs with the strength of the TCR signal...
  4. pmc Adaptor SKAP-55 binds p21 activating exchange factor RasGRP1 and negatively regulates the p21-ERK pathway in T-cells
    Helga Schneider
    Cell Signalling Section, Department of Pathology, University of Cambridge, Cambridge, United Kingdom
    PLoS ONE 3:e1718. 2008
    ..Our findings indicate that SKAP-55 has a dual role in regulating p21(ras)-ERK pathway via RasGRP1, as a possible mechanism to restrict activation during T-cell adhesion...
  5. pmc Regulation of the Src kinase-associated phosphoprotein 55 homologue by the protein tyrosine phosphatase PTP-PEST in the control of cell motility
    Emily Ayoub
    Goodman Cancer Research Centre and Department of Biochemistry, McGill University, Montreal, Quebec H3A 1A3, Canada
    J Biol Chem 288:25739-48. 2013
    ..These findings suggest a novel role of SKAP-Hom and its phosphorylation in the regulation of cellular motility. Moreover, these results open new avenues by which PTP-PEST regulates cellular migration, a hallmark of metastasis. ..
  6. pmc ADAP and SKAP55 deficiency suppresses PD-1 expression in CD8+ cytotoxic T lymphocytes for enhanced anti-tumor immunotherapy
    Chunyang Li
    Key Laboratory of Systems Biology, Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences, Shanghai, China
    EMBO Mol Med 7:754-69. 2015
    ..Together, we propose that targeting the unrecognized ADAP-SKAP55-NFATc1-PD-1 pathway might increase efficacy of anti-tumor immunotherapy. ..
  7. pmc SKAP1 is dispensable for chemokine-induced migration of primary T-cells
    Hongyan Wang
    Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK
    Immunol Lett 128:148-53. 2010
    Immune adaptors SLP-76, ADAP and SKAP1 (SKAP-55) play central roles in anti-CD3 induced 'inside-out' signalling for LFA-1 activation and ICAM-1 adhesion...
  8. pmc T cell receptor "inside-out" pathway via signaling module SKAP1-RapL regulates T cell motility and interactions in lymph nodes
    Monika Raab
    Cell Signaling Section, Department of Pathology, Tennis Court Road, University of Cambridge, Cambridge UK, CB2 1Q
    Immunity 32:541-56. 2010
    ..Here, we define the "inside-out" pathway mediated by N-terminal SKAP1 (SKAP-55) domain binding to the C-terminal SARAH domain of RapL...
  9. pmc HPK1 associates with SKAP-HOM to negatively regulate Rap1-mediated B-lymphocyte adhesion
    Sebastian Königsberger
    Department of Molecular Biology, University of Salzburg, Salzburg, Austria
    PLoS ONE 5:. 2010
    ..Being inducibly recruited to membrane-proximal signalling scaffolds to regulate NFAT, AP-1 and NFkappaB-mediated gene transcription in T-cells, the function of HPK1 in B-cells to date remains rather ill-defined...
  10. pmc The pleckstrin homology domain in the SKAP55 adapter protein defines the ability of the adapter protein ADAP to regulate integrin function and NF-kappaB activation
    Brandon J Burbach
    Department of Laboratory Medicine and Pathology, Center for Immunology, Masonic Cancer Center, University of Minnesota Medical School, Minneapolis, MN 55414, USA
    J Immunol 186:6227-37. 2011
    ....