Sirt2

Summary

Gene Symbol: Sirt2
Description: sirtuin 2
Alias: 5730427M03Rik, SIR2L2, Sir2l, NAD-dependent protein deacetylase sirtuin-2, NAD-dependent deacetylase sirtuin-2, SIR2-like protein 2, mSIR2L2, regulatory protein SIR2 homolog 2, silent mating type information regulation 2, (S.cerevisiae, homolog)-like; sirtuin 2
Species: mouse

Top Publications

  1. pmc SirT2 is a histone deacetylase with preference for histone H4 Lys 16 during mitosis
    Alejandro Vaquero
    Howard Hughes Medical Institute, Piscataway, NJ 08854, USA
    Genes Dev 20:1256-61. 2006
  2. pmc The NAD-dependent deacetylase sirtuin 2 is a suppressor of microglial activation and brain inflammation
    Teresa Faria Pais
    Cell and Molecular Neuroscience Unit, Instituto de Medicina Molecular, Lisboa, Portugal
    EMBO J 32:2603-16. 2013
  3. ncbi SIRT2 deacetylates FOXO3a in response to oxidative stress and caloric restriction
    Fei Wang
    USDA ARS Children s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
    Aging Cell 6:505-14. 2007
  4. pmc SIRT2 regulates adipocyte differentiation through FoxO1 acetylation/deacetylation
    Enxuan Jing
    Department of Cellular and Molecular Physiology, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA
    Cell Metab 6:105-14. 2007
  5. doi Sirt2 suppresses inflammatory responses in collagen-induced arthritis
    Jiangtao Lin
    Department of Orthopaedics, Qilu Hospital, Shandong University, 44 Wenhua Xi Road, Jinan, Shandong 250012, PR China Department of Orthopaedics, Yantaishan Hospital, 91 Jiefang Road, Yantai, Shandong 264001, PR China
    Biochem Biophys Res Commun 441:897-903. 2013
  6. doi PEP-1-SIRT2 inhibits inflammatory response and oxidative stress-induced cell death via expression of antioxidant enzymes in murine macrophages
    Mi Jin Kim
    Department of Biomedical Science and Research Institute of Bioscience and Biotechnology, Hallym University, Chunchon 200 702, Korea
    Free Radic Biol Med 63:432-45. 2013
  7. pmc SIRT2 suppresses adipocyte differentiation by deacetylating FOXO1 and enhancing FOXO1's repressive interaction with PPARgamma
    Fei Wang
    USDA ARS Children s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
    Mol Biol Cell 20:801-8. 2009
  8. pmc Dietary obesity-associated Hif1α activation in adipocytes restricts fatty acid oxidation and energy expenditure via suppression of the Sirt2-NAD+ system
    Jaya Krishnan
    Institute of Cell Biology, ETH Zurich, Switzerland
    Genes Dev 26:259-70. 2012
  9. pmc SIRT2 maintains genome integrity and suppresses tumorigenesis through regulating APC/C activity
    Hyun Seok Kim
    Genetics of Development and Disease Branch, 10 9N105, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Cancer Cell 20:487-99. 2011
  10. doi SIRT2 regulates NF-κB dependent gene expression through deacetylation of p65 Lys310
    Karin M Rothgiesser
    Institute of Veterinary Biochemistry and Molecular Biology, University of Zurich, Winterthurerstrase 190, 8057 Zurich, Switzerland
    J Cell Sci 123:4251-8. 2010

Research Grants

Scientific Experts

  • Lourdes Serrano
  • Natasha T Snider
  • M M Maxwell
  • Olaf Witt
  • Qiang Wang
  • Johan Auwerx
  • Phuongmai Nguyen
  • Fei Wang
  • Brian J North
  • Juliette Martin
  • Sudhanshu Shukla
  • K S Seo
  • Jonathan P Belman
  • M Erburu
  • Heyu Chen
  • Said Movahedi Naini
  • Jinyu Li
  • Filipa Cardoso
  • Deedee K Smart
  • Liang Zhang
  • Kim Newton
  • Danhong Wu
  • Yi Ping Wang
  • Amita Arora
  • Mei Ming
  • Xia Zhou
  • Weihai Ying
  • Giuseppe Lo Sasso
  • Ae Sin Lee
  • C Valle
  • K Fukui
  • Gopalakrishnan Ramakrishnan
  • Tomoaki Nagai
  • Takuma Misawa
  • Jiangtao Lin
  • Wulin Yang
  • Teresa Faria Pais
  • Yexin Li
  • Mi Jin Kim
  • Ines Taes
  • Haig A Eskandarian
  • Deveroux Ferguson
  • Xiaoxing Si
  • Bernhard Luscher
  • David A Sinclair
  • Hiroyasu Yamamoto
  • Shaday Michan
  • Vanita Chopra
  • Lei Liu
  • Anna Bobrowska
  • Gizem Donmez
  • H Zhu
  • J Alex Parker
  • Jaya Krishnan
  • Jiyeong Gal
  • Nisha Narayan
  • Hyun Seok Kim
  • Shaoping Ji
  • Bogdan Beirowski
  • Meritxell Orpinell
  • Yumiko Kawamura
  • Girdhar G Sharma
  • Karin M Rothgiesser
  • Anthony A Sauve
  • Hwei Ling Cheng
  • Qiang Tong
  • Enxuan Jing
  • Kazuhiko Suzuki
  • Subat Turdi
  • Cherie M Southwood
  • Alejandro Vaquero
  • Toula Bouras
  • Olivier Maurhofer
  • Jean Francois Dufour
  • Marie V St-Pierre
  • Saranya Rajendran
  • Maria L Balmer
  • K N Min
  • J Y Heo
  • Uma T Shankavaram
  • A Mai
  • C Kim
  • Don T Li
  • Paolo Carloni
  • Alice M Sheridan
  • R M Tordera
  • T Suzuki
  • Margarida Saraiva
  • M Shong
  • Xianting Ding

Detail Information

Publications62

  1. pmc SirT2 is a histone deacetylase with preference for histone H4 Lys 16 during mitosis
    Alejandro Vaquero
    Howard Hughes Medical Institute, Piscataway, NJ 08854, USA
    Genes Dev 20:1256-61. 2006
    The mammalian cytoplasmic protein SirT2 is a member of the Sir2 family of NAD+-dependent protein deacetylases involved in caloric restriction-dependent life span extension...
  2. pmc The NAD-dependent deacetylase sirtuin 2 is a suppressor of microglial activation and brain inflammation
    Teresa Faria Pais
    Cell and Molecular Neuroscience Unit, Instituto de Medicina Molecular, Lisboa, Portugal
    EMBO J 32:2603-16. 2013
    ..Here, we identified sirtuin 2 (SIRT2), an abundant deacetylase in the brain, as a major inhibitor of microglia-mediated inflammation and neurotoxicity...
  3. ncbi SIRT2 deacetylates FOXO3a in response to oxidative stress and caloric restriction
    Fei Wang
    USDA ARS Children s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
    Aging Cell 6:505-14. 2007
    ..The mammalian ortholog of Hst2, SIRT2, was shown to co-localize with microtubules and functions as alpha-tubulin deacetylase...
  4. pmc SIRT2 regulates adipocyte differentiation through FoxO1 acetylation/deacetylation
    Enxuan Jing
    Department of Cellular and Molecular Physiology, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA
    Cell Metab 6:105-14. 2007
    The family of mammalian Sirtuin proteins comprises seven members homologous to yeast Sir2. Here we show that SIRT2, a cytoplasmic sirtuin, is the most abundant sirtuin in adipocytes...
  5. doi Sirt2 suppresses inflammatory responses in collagen-induced arthritis
    Jiangtao Lin
    Department of Orthopaedics, Qilu Hospital, Shandong University, 44 Wenhua Xi Road, Jinan, Shandong 250012, PR China Department of Orthopaedics, Yantaishan Hospital, 91 Jiefang Road, Yantai, Shandong 264001, PR China
    Biochem Biophys Res Commun 441:897-903. 2013
    ..Here in this study, we demonstrate that Sirt2 inhibits collagen-induced arthritis (CIA) using in vivo and in vitro evidence...
  6. doi PEP-1-SIRT2 inhibits inflammatory response and oxidative stress-induced cell death via expression of antioxidant enzymes in murine macrophages
    Mi Jin Kim
    Department of Biomedical Science and Research Institute of Bioscience and Biotechnology, Hallym University, Chunchon 200 702, Korea
    Free Radic Biol Med 63:432-45. 2013
    Sirtuin 2 (SIRT2), a member of the sirtuin family of proteins, plays an important role in cell survival. However, the biological function of SIRT2 protein is unclear with respect to inflammation and oxidative stress...
  7. pmc SIRT2 suppresses adipocyte differentiation by deacetylating FOXO1 and enhancing FOXO1's repressive interaction with PPARgamma
    Fei Wang
    USDA ARS Children s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
    Mol Biol Cell 20:801-8. 2009
    ..have previously reported that caloric restriction increases the expression of one of the seven mammalian sirtuins, SIRT2, in tissues such as white adipose tissue...
  8. pmc Dietary obesity-associated Hif1α activation in adipocytes restricts fatty acid oxidation and energy expenditure via suppression of the Sirt2-NAD+ system
    Jaya Krishnan
    Institute of Cell Biology, ETH Zurich, Switzerland
    Genes Dev 26:259-70. 2012
    ..is linked to its capacity to suppress β-oxidation, in part, through transcriptional repression of sirtuin 2 (Sirt2) NAD(+)-dependent deacetylase...
  9. pmc SIRT2 maintains genome integrity and suppresses tumorigenesis through regulating APC/C activity
    Hyun Seok Kim
    Genetics of Development and Disease Branch, 10 9N105, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Cancer Cell 20:487-99. 2011
    ..To investigate the physiological functions of SIRT2 in development and tumorigenesis, we disrupted Sirt2 in mice...
  10. doi SIRT2 regulates NF-κB dependent gene expression through deacetylation of p65 Lys310
    Karin M Rothgiesser
    Institute of Veterinary Biochemistry and Molecular Biology, University of Zurich, Winterthurerstrase 190, 8057 Zurich, Switzerland
    J Cell Sci 123:4251-8. 2010
    ..In this study, we identified SIRT2 as a deacetylase of the transcription factor p65...
  11. pmc Sir-two-homolog 2 (Sirt2) modulates peripheral myelination through polarity protein Par-3/atypical protein kinase C (aPKC) signaling
    Bogdan Beirowski
    Department of Genetics, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 108:E952-61. 2011
    ..to examine peripheral nerve myelination and identified the NAD(+)-dependent deacetylase Sir-two-homolog 2 (Sirt2) as a protein likely to be involved in myelination...
  12. pmc The Sirtuin 2 microtubule deacetylase is an abundant neuronal protein that accumulates in the aging CNS
    Michele M Maxwell
    MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Boston, MA 02115, USA
    Hum Mol Genet 20:3986-96. 2011
    Sirtuin 2 (SIRT2) is one of seven known mammalian protein deacetylases homologous to the yeast master lifespan regulator Sir2...
  13. pmc Mammalian SIRT2 inhibits keratin 19 expression and is a tumor suppressor in skin
    Mei Ming
    Section of Dermatology, Department of Medicine, University of Chicago, Chicago, IL, USA
    Exp Dermatol 23:207-9. 2014
    b>SIRT2 is a member of the mammalian sirtuin family (SIRT1-7). As compared with other sirtuins, SIRT2 is found primarily in the cytoplasm. It regulates multiple physiological processes...
  14. pmc Regulation of G6PD acetylation by SIRT2 and KAT9 modulates NADPH homeostasis and cell survival during oxidative stress
    Yi Ping Wang
    Key Laboratory of Molecular Medicine of Ministry of Education and Institutes of Biomedical Sciences, Shanghai Medical College College of Life Science Fudan University, Shanghai, China
    EMBO J 33:1304-20. 2014
    ..Moreover, we show that cells sense extracellular oxidative stimuli to decrease G6PD acetylation in a SIRT2-dependent manner...
  15. doi SIRT2 regulates tumour hypoxia response by promoting HIF-1α hydroxylation
    K S Seo
    Department of Biochemistry, Chungnam National University School of Medicine, Daejeon, Korea
    Oncogene 34:1354-62. 2015
    ..In this study, it is shown that SIRT2-mediated deacetylation of HIF-1α regulates its stability in tumour cells...
  16. pmc Is SIRT2 required for necroptosis?
    Kim Newton
    Genentech, Inc, South San Francisco, California 94080, USA
    Nature 506:E4-6. 2014
    ..Recently Narayan et al., reported that SIRT2 was required for necroptosis based on their findings that SIRT2 inhibition, knock-down or knock-out prevented ..
  17. doi Changes in microtubule-related proteins and autophagy in long-term vitamin E-deficient mice
    K Fukui
    Physiological Chemistry Laboratory, Department of Bioscience and Engineering, College of Systems Engineering and Sciences, Shibaura Institute of Technology, Saitama, Japan
    Free Radic Res 48:649-58. 2014
    ..These results indicate that the mechanisms of axonal injury in long-term vitamin E-deficient mice are related to dysfunction in microtubules assembly via alterations in microtubule-related proteins and autophagy...
  18. pmc Sirt2 deacetylase is a novel AKT binding partner critical for AKT activation by insulin
    Gopalakrishnan Ramakrishnan
    From the Cancer Institute and Department of Biochemistry, University of Mississippi Medical Center, Jackson, Mississippi 39216
    J Biol Chem 289:6054-66. 2014
    ..Here, we identify the cytoplasmic NAD(+)-dependent deacetylase, Sirt2, as a novel AKT interactor, required for optimal AKT activation...
  19. pmc SIRT2 regulates ciliogenesis and contributes to abnormal centrosome amplification caused by loss of polycystin-1
    Xia Zhou
    Department of Internal Medicine
    Hum Mol Genet 23:1644-55. 2014
    ..Here, we present for the first time that SIRT2, a nicotinamide adenine dinucleotide (NAD)-dependent deacetylase, regulates ciliogenesis and centrosome ..
  20. pmc Sirt2 functions in spindle organization and chromosome alignment in mouse oocyte meiosis
    Liang Zhang
    2State Key Laboratory of Reproductive Medicine, Nanjing Medical University, 140 Hanzhong Rd, Nanjing, Jiangsu, 210029 China
    FASEB J 28:1435-45. 2014
    ..Here, by confocal scanning and quantitative analysis, we show that specific depletion of Sirt2 in mouse oocytes results in spindle defects and chromosome disorganization (35.5±8.7 vs. 9.6±3...
  21. pmc Activation of GSK3β by Sirt2 is required for early lineage commitment of mouse embryonic stem cell
    Xiaoxing Si
    Clinical and Translational Research Center of Shanghai First Maternity and Infant Health Hospital, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Science and Technology, Tongji University, Shanghai, China
    PLoS ONE 8:e76699. 2013
    b>Sirt2, a member of the NAD(+)-dependent protein deacetylase family, is increasingly recognized as a critical regulator of the cell cycle, cellular necrosis and cytoskeleton organization...
  22. doi Poly(ADP-ribose) polymerase mediates both cell death and ATP decreases in SIRT2 inhibitor AGK2-treated microglial BV2 cells
    Yexin Li
    School of Biomedical Engineering and Med X Research Institute, Shanghai Jiao Tong University, Shanghai 200030, PR China
    Neurosci Lett 544:36-40. 2013
    Sirtuin 2 (SIRT2), a sirtuin family protein, is a tubulin deacetylase...
  23. doi SIRT2 negatively regulates insulin resistance in C2C12 skeletal muscle cells
    Amita Arora
    Kusuma School of Biological Sciences, Indian Institute of Technology Delhi, Hauz Khas, New Delhi 110016, India
    Biochim Biophys Acta 1842:1372-8. 2014
    b>SIRT2 is primarily a cytoplasmic protein deacetylase and is abundantly expressed in metabolically active tissues like adipocytes and brain. However, its role, if any, in regulating insulin signaling in skeletal muscle cells, is not known...
  24. pmc SIRT2 induces the checkpoint kinase BubR1 to increase lifespan
    Brian J North
    Department of Genetics, Paul F Glenn Laboratories for the Biological Mechanisms of Aging Harvard Medical School, Boston, MA, USA
    EMBO J 33:1438-53. 2014
    ..Here, we show that the loss of BubR1 levels with age is due to a decline in NAD(+) and the ability of SIRT2 to maintain lysine-668 of BubR1 in a deacetylated state, which is counteracted by the acetyltransferase CBP...
  25. pmc SIRT2 interacts with β-catenin to inhibit Wnt signaling output in response to radiation-induced stress
    Phuongmai Nguyen
    Radiation Oncology Branch, NCI, NIH, Bethesda, Maryland
    Mol Cancer Res 12:1244-53. 2014
    ..Therefore, the hypothesis that sirtuin 2 (SIRT2) directly interacts with β-catenin and whether this interaction alters the expression of Wnt target genes to ..
  26. pmc Tissue-specific deregulation of selected HDACs characterizes ALS progression in mouse models: pharmacological characterization of SIRT1 and SIRT2 pathways
    C Valle
    1 Institute for Cell Biology and Neurobiology, CNR, Rome, Italy 2 Fondazione Santa Lucia IRCCS, Rome, Italy
    Cell Death Dis 5:e1296. 2014
    ..We have then focused on class III histone deacetylases SIRT1 and SIRT2 that are considered relevant in neurodegenerative diseases...
  27. doi SIRT2 ameliorates lipopolysaccharide-induced inflammation in macrophages
    Ae Sin Lee
    Department of Internal Medicine, Chonbuk National University Medical School, Jeonju, Republic of Korea
    Biochem Biophys Res Commun 450:1363-9. 2014
    b>SIRT2 is a NAD(+)-dependent deacetylases and associated with numerous processes such as infection, carcinogenesis, DNA damage and cell cycle regulation. However, the role of SIRT2 in inflammatory process in macrophage remains unclear.
  28. pmc SIRT2 deficiency modulates macrophage polarization and susceptibility to experimental colitis
    Giuseppe Lo Sasso
    Laboratory for Integrative and Systems Physiology, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland
    PLoS ONE 9:e103573. 2014
    b>SIRT2 belongs to a highly conserved family of NAD+-dependent deacylases, consisting of seven members (SIRT1-SIRT7), which vary in subcellular localizations and have substrates ranging from histones to transcription factors and enzymes...
  29. doi SIRT2 is required for lipopolysaccharide-induced activation of BV2 microglia
    Heyu Chen
    aMed X Research Institute, School of Biomedical Engineering bDepartment of Neurology, Ruijin Hospital cDepartment of Neurology, Third People s Hospital, Shanghai Jiao Tong University, Shanghai, People s Republic of China
    Neuroreport 26:88-93. 2015
    It has been reported that inhibition of sirtuin 2 (SIRT2), a sirtuin family protein, can decrease cellular and tissue injuries in models of Parkinson's disease (PD) and Huntington's disease (HD); however, the mechanisms underlying these ..
  30. pmc Acetylation of TUG protein promotes the accumulation of GLUT4 glucose transporters in an insulin-responsive intracellular compartment
    Jonathan P Belman
    From the Section of Endocrinology and Metabolism, Department of Internal Medicine, Department of Cell Biology
    J Biol Chem 290:4447-63. 2015
    ..Sirtuin 2 (SIRT2), a NAD(+)-dependent deacetylase, bound TUG and deacetylated the TUG peptide...
  31. pmc Myeloid Sirtuin 2 Expression Does Not Impact Long-Term Mycobacterium tuberculosis Control
    Filipa Cardoso
    Life and Health Sciences Research Institute ICVS, School of Health Sciences, University of Minho, Braga, Portugal ICVS 3B s PT Government Associate Laboratory, Braga Guimarães, Portugal
    PLoS ONE 10:e0131904. 2015
    ..Recently, Sirt2 was shown to prevent the development of inflammatory processes and its expression favors acute Listeria ..
  32. pmc Group IVA Cytosolic Phospholipase A2 Regulates the G2-to-M Transition by Modulating the Activity of Tumor Suppressor SIRT2
    Said Movahedi Naini
    Renal Division, Brigham and Women s Hospital, Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA
    Mol Cell Biol 35:3768-84. 2015
    The G2-to-M transition (or prophase) checkpoint of the cell cycle is a critical regulator of mitotic entry. SIRT2, a tumor suppressor gene, contributes to the control of this checkpoint by blocking mitotic entry under cellular stress...
  33. pmc Radiation-Induced Alteration of the Brain Proteome: Understanding the Role of the Sirtuin 2 Deacetylase in a Murine Model
    Sudhanshu Shukla
    Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institute of Health, 10 Center Drive, Bethesda, Maryland 20892, United States
    J Proteome Res 14:4104-17. 2015
    ..A deacetylase expressed in the central nervous system, Sirtuin 2 (SIRT2), has been linked to neurodegeneration...
  34. pmc Insight into the Mechanism of Intramolecular Inhibition of the Catalytic Activity of Sirtuin 2 (SIRT2)
    Jinyu Li
    Computational Biomedicine, Institute for Advanced Simulation IAS 5 and Institute of Neuroscience and Medicine INM 9, Forschungszentrum Julich, 52425, Julich, Germany Institute of Biochemistry and Molecular Biology, RWTH Aachen University, 52057, Aachen, Germany
    PLoS ONE 10:e0139095. 2015
    Sirtuin 2 (SIRT2) is a NAD+-dependent deacetylase that has been associated with neurodegeneration and cancer...
  35. doi Chronic stress and antidepressant induced changes in Hdac5 and Sirt2 affect synaptic plasticity
    M Erburu
    Dept Pharmacology and Toxicology University of Navarra, Pamplona, Spain
    Eur Neuropsychopharmacol 25:2036-48. 2015
    ..CSDS increased Hdac5 and Sirt2 mRNA whereas repeated imipramine did the opposite...
  36. doi Nutritional stress exacerbates hepatic steatosis induced by deletion of the histidine nucleotide-binding (Hint2) mitochondrial protein
    Juliette Martin
    Department of Clinical Research, University of Bern, Bern, Switzerland and Department of Hepatology, Gastroenterology and
    Am J Physiol Gastrointest Liver Physiol 310:G497-509. 2016
    ..The absence of Hint2 deregulates the posttranslational modification of several mitochondrial proteins, which impedes the adaptation to episodes of nutritional stress. ..
  37. pmc Sirtuin 2 (SIRT2) enhances 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced nigrostriatal damage via deacetylating forkhead box O3a (Foxo3a) and activating Bim protein
    Lei Liu
    Department of Neuroscience, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    J Biol Chem 287:32307-11. 2012
    ..b>SIRT2 is a strong deacetylase that is highly expressed in brain. It has been associated with neurodegenerative diseases...
  38. ncbi SIRT1 deacetylation and repression of p300 involves lysine residues 1020/1024 within the cell cycle regulatory domain 1
    Toula Bouras
    Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, 3970 Reservoir Rd, Washington, DC 20057, USA
    J Biol Chem 280:10264-76. 2005
    ..Because p300 is a limiting transcriptional cofactor, deacetylation and repression of p300 by SIRT1 may serve an important integration point during metabolism and cellular differentiation...
  39. pmc Essential role of SIRT1 signaling in the nucleus accumbens in cocaine and morphine action
    Deveroux Ferguson
    Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 78229, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, and Laboratory of Muscle Stem Cells and Gene Regulation, National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, Maryland 20892
    J Neurosci 33:16088-98. 2013
    ..Here, we establish an essential role for SIRT1 and SIRT2 in regulating behavioral responses to cocaine and morphine through actions in the nucleus accumbens (NAc), a key ..
  40. doi Regulation of adipogenesis by cytoskeleton remodelling is facilitated by acetyltransferase MEC-17-dependent acetylation of α-tubulin
    Wulin Yang
    Laboratory of Metabolic Medicine, Singapore Bioimaging Consortium, Agency for Science, Technology and Research A STAR, Singapore
    Biochem J 449:605-12. 2013
    ..Moreover, acetylation of α-tubulin is under the control of the acetyltransferase MEC-17 and deacetylases SIRT2 (Sirtuin 2) and HDAC6 (histone deacetylase 6)...
  41. doi Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome
    Takuma Misawa
    Laboratory of Host Defense, World Premier International Research Center Immunology Frontier Research Center, Osaka University, Osaka, Japan
    Nat Immunol 14:454-60. 2013
    ..Therefore, in addition to direct activation of NLRP3, the creation of optimal sites for signal transduction by microtubules is required for activation of the entire NLRP3 inflammasome...
  42. doi Furry promotes acetylation of microtubules in the mitotic spindle by inhibition of SIRT2 tubulin deacetylase
    Tomoaki Nagai
    Department of Biomolecular Sciences, Graduate School of Life Sciences, Tohoku University, Sendai, Miyagi 980 8578, Japan
    J Cell Sci 126:4369-80. 2013
    ..We also found that Fry binds to the tubulin deacetylase SIRT2, preferentially in mitotic cells...
  43. pmc The tumor suppressor SirT2 regulates cell cycle progression and genome stability by modulating the mitotic deposition of H4K20 methylation
    Lourdes Serrano
    Department of Genetics, The Human Genetics Institute of New Jersey, Rutgers University, Piscataway, New Jersey 08854, USA
    Genes Dev 27:639-53. 2013
    ..However, the mechanisms involved in the regulation of this event are not well understood. Here we show that SirT2 regulates H4K20me1 deposition through the deacetylation of H4K16Ac (acetylation of H4K16) and determines the ..
  44. doi A role for SIRT2-dependent histone H3K18 deacetylation in bacterial infection
    Haig A Eskandarian
    Unité des Interactions Bactéries Cellules, Institut Pasteur, Paris, France
    Science 341:1238858. 2013
    ..We found that during infection with the bacterium Listeria monocytogenes, the host deacetylase sirtuin 2 (SIRT2) translocates to the nucleus, in a manner dependent on the bacterial factor InlB...
  45. doi SIRT2 interferes with autophagy-mediated degradation of protein aggregates in neuronal cells under proteasome inhibition
    Jiyeong Gal
    College of Pharmacy, CHA University, Seongnam si, South Korea
    Neurochem Int 61:992-1000. 2012
    ..Sirtuin-2 (SIRT2) is a class III histone deacetylase that is expressed abundantly in aging brain tissue...
  46. pmc Integration of β-catenin, sirtuin, and FOXO signaling protects from mutant huntingtin toxicity
    J Alex Parker
    INSERM, Unit 894, Laboratory of Neuronal Cell Biology and Pathology, 75014 Paris, France
    J Neurosci 32:12630-40. 2012
    ..Taken together, these results suggest that integration of β-catenin, sirtuin and FOXO signaling protects from the early phases of mutant huntingtin toxicity...
  47. doi The NAD-dependent deacetylase SIRT2 is required for programmed necrosis
    Nisha Narayan
    Center for Molecular Medicine, National Heart, Lung and Blood Institute, NIH, Bethesda, Maryland 20892, USA
    Nature 492:199-204. 2012
    ..Here, we show that the NAD-dependent deacetylase SIRT2 binds constitutively to RIP3 and that deletion or knockdown of SIRT2 prevents formation of the RIP1-RIP3 complex ..
  48. pmc Glucose and SIRT2 reciprocally mediate the regulation of keratin 8 by lysine acetylation
    Natasha T Snider
    Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Cell Biol 200:241-7. 2013
    ..The NAD-dependent deacetylase sirtuin 2 (SIRT2) associated with and deacetylated K8...
  49. doi Hdac6 deletion delays disease progression in the SOD1G93A mouse model of ALS
    Ines Taes
    Experimental Neurology, Department of Neurosciences, Leuven Research Institute for Neuroscience and Disease LIND, University of Leuven KU Leuven, Leuven, Belgium
    Hum Mol Genet 22:1783-90. 2013
    ..of the α-tubulin deacetylating enzymes, histone deacetylase 6 (Hdac6) and silent information regulator 2 (Sirt2), is thought to be an interesting therapeutic strategy for these conditions...
  50. pmc The sirtuin 2 inhibitor AK-7 is neuroprotective in Huntington's disease mouse models
    Vanita Chopra
    Department of Neurology, Harvard Medical School, Massachusetts General Hospital, Charlestown, MA 02129 4404, USA
    Cell Rep 2:1492-7. 2012
    Inhibition of sirtuin 2 (SIRT2) deacetylase mediates protective effects in cell and invertebrate models of Parkinson's disease and Huntington's disease (HD)...
  51. pmc SIRT2 ablation has no effect on tubulin acetylation in brain, cholesterol biosynthesis or the progression of Huntington's disease phenotypes in vivo
    Anna Bobrowska
    Department of Medical and Molecular Genetics, King s College London, London, United Kingdom
    PLoS ONE 7:e34805. 2012
    ..Previous studies in invertebrate and cell culture HD models have suggested that inhibition of SIRT2 could have beneficial consequences on disease progression...
  52. pmc The QKI-PLP pathway controls SIRT2 abundance in CNS myelin
    H Zhu
    Department of Neurology, University of Kentucky, Lexington, Kentucky, USA
    Glia 60:69-82. 2012
    Sirtuin 2 (SIRT2), a nicotinamide adenine dinucleotide (NAD)-dependent deacetylase expressed by oligodendrocytes (OLs), the myelin-producing cells of the central nervous system (CNS), is markedly up-regulated during active myelination (..
  53. doi Sirt2 is a novel in vivo downstream target of Nkx2.2 and enhances oligodendroglial cell differentiation
    Shaoping Ji
    Laboratory of Molecular Cell Biology, College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, SK, S7N 5C9, Canada
    J Mol Cell Biol 3:351-9. 2011
    Although Sirt2 is primarily expressed in oligodendrocytes of the central nervous system, its role in oligodendroglial lineage differentiation is not fully understood. Our findings demonstrate that the transcription factor Nkx2...
  54. pmc The ATAC acetyl transferase complex controls mitotic progression by targeting non-histone substrates
    Meritxell Orpinell
    Department of Functional Genomics, Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS UMR 7104, INSERM U964, Universite de Strasbourg, Illkirch Cedex, France
    EMBO J 29:2381-94. 2010
    ..mitotic function: ATAC/Gcn5-mediated acetylation targets Cyclin A for degradation, which in turn regulates the SIRT2 deacetylase activity...
  55. ncbi Cloning and characterization of two mouse genes with homology to the yeast Sir2 gene
    Y H Yang
    Department of Genetics, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut, 06536, USA
    Genomics 69:355-69. 2000
    ..Our results revealed that the two mouse Sir2-like proteins (mSIR2L2 and mSIR2L3) are most similar to the human Sir2-like proteins SIR2L2 and SIR2L3, respectively...
  56. pmc Sirt3 protects in vitro-fertilized mouse preimplantation embryos against oxidative stress-induced p53-mediated developmental arrest
    Yumiko Kawamura
    Department of Physiological Chemistry and Metabolism, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    J Clin Invest 120:2817-28. 2010
    ..These results indicate that Sirt3 plays a protective role in preimplantation embryos against stress conditions during in vitro fertilization and culture...
  57. pmc MOF and histone H4 acetylation at lysine 16 are critical for DNA damage response and double-strand break repair
    Girdhar G Sharma
    Washington University School of Medicine, St Louis, Missouri 63108, USA
    Mol Cell Biol 30:3582-95. 2010
    ..We propose that MOF, through H4K16ac (histone code), has a critical role at multiple stages in the cellular DNA damage response and DSB repair...
  58. doi HDAC family: What are the cancer relevant targets?
    Olaf Witt
    CCU Pediatric Oncology G340, German Cancer Research Center, Im Neuenheimer Feld 280, Heidelberg, Germany
    Cancer Lett 277:8-21. 2009
    ..The aim of this review is to discuss individual HDAC family members as drug targets in cancer taking into consideration their function under physiological conditions and their oncogenic potential in malignant disease...
  59. ncbi Catalase alleviates cardiomyocyte dysfunction in diabetes: role of Akt, Forkhead transcriptional factor and silent information regulator 2
    Subat Turdi
    Division of Pharmaceutical Sciences and Center for Cardiovascular Research and Alternative Medicine, University of Wyoming, Laramie, WY 82071, USA
    Life Sci 81:895-905. 2007
    ..blot analysis revealed that diabetes reduced Akt phosphorylation, enhanced the silent information regulator 2 (Sirt2), and upregulated Forkhead transcriptional factor Foxo3a as well as glycogen synthase kinase-3beta (GSK-3beta) and ..
  60. ncbi Resveratrol abolishes resistance to axonal degeneration in slow Wallerian degeneration (WldS) mice: activation of SIRT2, an NAD-dependent tubulin deacetylase
    Kazuhiko Suzuki
    Molecular Neurobiology Laboratory, Division of Integrated Life Science, Hokkaido University Graduate School of Life Science, Sapporo 060 0810, Japan
    Biochem Biophys Res Commun 359:665-71. 2007
    ..This promoting effect on tubulin deacetylation was mimicked by NAD, suggesting the involvement of SIRT2, an NAD-dependent tubulin deacetylase...
  61. ncbi Microtubule deacetylases, SirT2 and HDAC6, in the nervous system
    Cherie M Southwood
    Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, 3216 Scott Hall, 540 E Canfield Ave, Detroit, MI 48201, USA
    Neurochem Res 32:187-95. 2007
    ..Herein, we analyze two microtubule regulatory alpha-tubulin deacetylases, histone deacetylase-6 (HDAC6) and SirT2. HDAC6 is expressed by most neurons but is abundant in cerebellar Purkinje cells...

Research Grants1

  1. RNAi-mediated Silencing of Mutant Superoxide Dismutase
    MICHELE MAXWELL; Fiscal Year: 2006
    ..In addition, the therapeutic potential of RNAi will be assessed using viral delivery of shRNA to the spinal cords of mutant SOD1 transgenic mice. ..