Sirt1

Summary

Gene Symbol: Sirt1
Description: sirtuin 1
Alias: AA673258, SIR2L1, Sir2, Sir2a, Sir2alpha, NAD-dependent protein deacetylase sirtuin-1, SIR2-like protein 1, regulatory protein SIR2 homolog 1, sirtuin 1 ((silent mating type information regulation 2, homolog) 1
Species: mouse

Top Publications

  1. pmc Age-associated loss of Sirt1-mediated enhancement of glucose-stimulated insulin secretion in beta cell-specific Sirt1-overexpressing (BESTO) mice
    Kathryn Moynihan Ramsey
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, MO 63110, USA
    Aging Cell 7:78-88. 2008
  2. ncbi hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase
    H Vaziri
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Cell 107:149-59. 2001
  3. pmc AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
    Carles Canto
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, 67404 Illkirch, France
    Nature 458:1056-60. 2009
  4. ncbi Negative control of p53 by Sir2alpha promotes cell survival under stress
    J Luo
    Institute of Cancer Genetics and Department of Pathology, College of Physicians and Surgeons, Columbia University, 1150 St Nicholas Avenue, New York, NY 10032, USA
    Cell 107:137-48. 2001
  5. ncbi Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
    S Imai
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    Nature 403:795-800. 2000
  6. ncbi SIRT1 transgenic mice show phenotypes resembling calorie restriction
    Laura Bordone
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Aging Cell 6:759-67. 2007
  7. pmc SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis
    Dohoon Kim
    Howard Hughes Medical Institute, Picower Insitute for Learning and Memory, RIKEN MIT Neuroscience Research Center, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Boston, MA, USA
    EMBO J 26:3169-79. 2007
  8. ncbi Sirt1 regulates aging and resistance to oxidative stress in the heart
    Ralph R Alcendor
    Cardiovascular Research Institute, Department of Cell Biology and Molecular Medicine, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ 07103, USA
    Circ Res 100:1512-21. 2007
  9. pmc Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice
    Rui Hong Wang
    Genetics of Development and Disease Branch, 10 9N105, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Cancer Cell 14:312-23. 2008
  10. ncbi Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses
    Wen Yong Chen
    Cancer Biology Program, The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University, Baltimore, Maryland 21231, USA
    Cell 123:437-48. 2005

Research Grants

Scientific Experts

Detail Information

Publications151 found, 100 shown here

  1. pmc Age-associated loss of Sirt1-mediated enhancement of glucose-stimulated insulin secretion in beta cell-specific Sirt1-overexpressing (BESTO) mice
    Kathryn Moynihan Ramsey
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, MO 63110, USA
    Aging Cell 7:78-88. 2008
    ..In mammals, the Sir2 ortholog Sirt1 promotes fat mobilization, fatty acid oxidation, glucose production, and insulin secretion in response to nutrient ..
  2. ncbi hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase
    H Vaziri
    Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
    Cell 107:149-59. 2001
    ..We show here that the protein product of the gene hSIR2(SIRT1), the human homolog of the S...
  3. pmc AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
    Carles Canto
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, 67404 Illkirch, France
    Nature 458:1056-60. 2009
    ..skeletal muscle by acting in coordination with another metabolic sensor, the NAD+-dependent type III deacetylase SIRT1. AMPK enhances SIRT1 activity by increasing cellular NAD+ levels, resulting in the deacetylation and modulation of ..
  4. ncbi Negative control of p53 by Sir2alpha promotes cell survival under stress
    J Luo
    Institute of Cancer Genetics and Department of Pathology, College of Physicians and Surgeons, Columbia University, 1150 St Nicholas Avenue, New York, NY 10032, USA
    Cell 107:137-48. 2001
    ..Here, we show that mammalian Sir2alpha physically interacts with p53 and attenuates p53-mediated functions...
  5. ncbi Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
    S Imai
    Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    Nature 403:795-800. 2000
    Yeast Sir2 is a heterochromatin component that silences transcription at silent mating loci, telomeres and the ribosomal DNA, and that also suppresses recombination in the rDNA and extends replicative life span...
  6. ncbi SIRT1 transgenic mice show phenotypes resembling calorie restriction
    Laura Bordone
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Aging Cell 6:759-67. 2007
    We generated mice that overexpress the sirtuin, SIRT1. Transgenic mice have been generated by knocking in SIRT1 cDNA into the beta-actin locus...
  7. pmc SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis
    Dohoon Kim
    Howard Hughes Medical Institute, Picower Insitute for Learning and Memory, RIKEN MIT Neuroscience Research Center, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Boston, MA, USA
    EMBO J 26:3169-79. 2007
    ..Here, we report that a human homologue of SIR2, SIRT1, is upregulated in mouse models for AD, ALS and in primary neurons challenged with neurotoxic insults...
  8. ncbi Sirt1 regulates aging and resistance to oxidative stress in the heart
    Ralph R Alcendor
    Cardiovascular Research Institute, Department of Cell Biology and Molecular Medicine, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ 07103, USA
    Circ Res 100:1512-21. 2007
    ..We addressed this issue by using transgenic mice with heart-specific overexpression of Sirt1, a mammalian homolog of Sir2...
  9. pmc Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice
    Rui Hong Wang
    Genetics of Development and Disease Branch, 10 9N105, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Cancer Cell 14:312-23. 2008
    ..Here we mutated the Sirt1 gene, a homolog of yeast Sir2, in mice to study its function...
  10. ncbi Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses
    Wen Yong Chen
    Cancer Biology Program, The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University, Baltimore, Maryland 21231, USA
    Cell 123:437-48. 2005
    ..by which the loss of HIC1 function promotes tumorigenesis is via activating the stress-controlling protein SIRT1 and thereby attenuating p53 function...
  11. ncbi SIRT1 deacetylates and positively regulates the nuclear receptor LXR
    Xiaoling Li
    Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Mol Cell 28:91-106. 2007
    The NAD(+)-dependent deacetylase Sir2 regulates life span in lower eukaryotes. The mammalian ortholog SIRT1 regulates physiological processes including apoptosis, fat metabolism, glucose homeostasis, and neurodegeneration...
  12. ncbi Sir2 regulates skeletal muscle differentiation as a potential sensor of the redox state
    Marcella Fulco
    Muscle Gene Expression Group, Laboratory of Muscle Biology, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Cell 12:51-62. 2003
    b>Sir2 is a NAD(+)-dependent histone deacetylase that controls gene silencing, cell cycle, DNA damage repair, and life span...
  13. pmc Phosphorylation regulates SIRT1 function
    Tsutomu Sasaki
    Neuroscience Graduate Program, University of Virginia, Charlottesville, Virginia, United States of America
    PLoS ONE 3:e4020. 2008
    ..We previously reported that the level of SIRT1, the mammalian homologue of SIR2 [7], [8], is coupled to the level of mitotic activity in cells both in vitro and ..
  14. pmc Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma
    Frederic Picard
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Nature 429:771-6. 2004
    ..Here we show that the mammalian SIR2 orthologue, Sirt1 (sirtuin 1), activates a critical component of calorie restriction in mammals; that is, fat mobilization in white ..
  15. pmc SIRT1 is essential for normal cognitive function and synaptic plasticity
    Shaday Michan
    Paul F Glenn Laboratories, Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 30:9695-707. 2010
    ..The mammalian nicotinamide-adenine dinucleotide-dependent deacetylase SIRT1 impacts different processes potentially involved in the maintenance of brain integrity, such as chromatin ..
  16. ncbi Mammalian SIRT1 represses forkhead transcription factors
    Maria Carla Motta
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Cell 116:551-63. 2004
    ..elegans. Here we show that the mammalian SIR2 ortholog SIRT1 deacetylates and represses the activity of the forkhead transcription factor Foxo3a and other mammalian forkhead ..
  17. ncbi Nucleocytoplasmic shuttling of the NAD+-dependent histone deacetylase SIRT1
    Masaya Tanno
    Department of Pharmacology, Sapporo Medical University, Japan
    J Biol Chem 282:6823-32. 2007
    ..b>SIRT1, a mammalian Sir2 ortholog, deacetylates histones and various transcription factors, including p53, FOXO proteins, ..
  18. ncbi Increased dosage of mammalian Sir2 in pancreatic beta cells enhances glucose-stimulated insulin secretion in mice
    Kathryn A Moynihan
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cell Metab 2:105-17. 2005
    ..Here we show that increased dosage of Sirt1, the mammalian Sir2 ortholog, in pancreatic beta cells improves glucose tolerance and enhances insulin secretion ..
  19. pmc SIRT1 regulates the function of the Nijmegen breakage syndrome protein
    Zhigang Yuan
    H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
    Mol Cell 27:149-62. 2007
    ..Here, we report that NBS1 is an acetylated protein and that the acetylation level is tightly regulated by the SIRT1 deacetylase...
  20. pmc Histone deacetylase SIRT1 modulates neuronal differentiation by its nuclear translocation
    Shin Hisahara
    Department of Pharmacology, Sapporo Medical University, Sapporo 060 8556, Japan
    Proc Natl Acad Sci U S A 105:15599-604. 2008
    ..We show that SIRT1, an NAD(+)-dependent histone deacetylase, modulates neuronal differentiation...
  21. pmc Sirtuin 1 regulation of developmental genes during differentiation of stem cells
    Vincenzo Calvanese
    Department of Immunology and Oncology, Centro Nacional de Biotecnologia, Consejo Superior de Investigaciones Cientificas, 28049 Madrid, Spain
    Proc Natl Acad Sci U S A 107:13736-41. 2010
    The longevity-promoting NAD+-dependent class III histone deacetylase Sirtuin 1 (SIRT1) is involved in stem cell function by controlling cell fate decision and/or by regulating the p53-dependent expression of NANOG...
  22. pmc Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity
    Hiroaki Daitoku
    Center for Tsukuba Advanced Research Alliance, University of Tsukuba, 1 1 1 Ten noudai, Tsukuba, Ibaraki 305 8577, Japan
    Proc Natl Acad Sci U S A 101:10042-7. 2004
    ..the Forkhead transcription factor FOXO and the NAD-dependent histone deacetylase silent information regulator 2 (Sir2)...
  23. ncbi Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration
    Toshiyuki Araki
    Department of Pathology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Science 305:1010-3. 2004
    ..Furthermore, we demonstrate that SIRT1, a mammalian ortholog of Sir2, is the downstream effector of increased Nmnat activity that leads to axonal ..
  24. ncbi SIRT1 is significantly elevated in mouse and human prostate cancer
    Derek M Huffman
    Division of Physiology and Metabolism, Department of Nutrition Sciences, University of Alabama at Birmingham, 1670 University Boulevard, Birmingham, AL 35294, USA
    Cancer Res 67:6612-8. 2007
    Evidence suggests that the histone deacetylase, SIRT1, is a mediator of life span extension by calorie restriction; however, SIRT1 may paradoxically increase the risk of cancer...
  25. pmc Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer
    Daniel Herranz
    Tumor Suppression Group, Spanish National Cancer Research Center, 3 Melchor Fernandez Almagro Street, Madrid E 28029, Spain
    Nat Commun 1:3. 2010
    ..in a variety of lower organisms, and this has prompted interest in the effects of its closest mammalian homologue, Sirt1, on ageing and cancer...
  26. pmc Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation
    Aparna Purushotham
    Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Cell Metab 9:327-38. 2009
    ..b>SIRT1, a NAD+-dependent protein deacetylase, is an important regulator of energy homeostasis in response to nutrient ..
  27. ncbi Activation of Sirt1 decreases adipocyte formation during osteoblast differentiation of mesenchymal stem cells
    Carl Magnus Bäckesjö
    Department for Clinical Science, Intervention and Technology CLINTEC, Division of Orthopedics, Karolinska Institutet, Karolinska University Hospital, Huddinge, Sweden
    J Bone Miner Res 21:993-1002. 2006
    ..However, adipocytes are also formed. We showed that activation of the nuclear protein deacetylase Sirt1 reduces adipocyte formation and promotes osteoblast differentiation.
  28. doi Circadian control of the NAD+ salvage pathway by CLOCK-SIRT1
    Yasukazu Nakahata
    Department of Pharmacology, School of Medicine, University of California, Irvine, Irvine, CA 92697, USA
    Science 324:654-7. 2009
    ..whose activity is counterbalanced by the nicotinamide adenine dinucleotide (NAD+)-dependent histone deacetylase SIRT1. Here we show that intracellular NAD+ levels cycle with a 24-hour rhythm, an oscillation driven by the circadian ..
  29. pmc SIRT1 promotes the central adaptive response to diet restriction through activation of the dorsomedial and lateral nuclei of the hypothalamus
    Akiko Satoh
    Department of Developmental Biology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    J Neurosci 30:10220-32. 2010
    ..the effects of diet restriction is the mammalian nicotinamide adenine dinucleotide (NAD)-dependent deacetylase SIRT1. Here we demonstrate that diet restriction significantly increases SIRT1 protein levels and induces neural ..
  30. pmc Induction of Sirt1 by mechanical stretch of skeletal muscle through the early response factor EGR1 triggers an antioxidative response
    Patricia S Pardo
    Division of Pulmonary, Critical Care Medicine, and Sleep, Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 286:2559-66. 2011
    ..The NAD-dependent protein deacetylase SIRT1 is involved in the protection against oxidative stress by enhancing FOXO-driven Sod2 transcription...
  31. doi Salermide, a Sirtuin inhibitor with a strong cancer-specific proapoptotic effect
    E Lara
    Cancer Epigenetics Laboratory, Spanish National Cancer Research Centre CNIO, Madrid, Spain
    Oncogene 28:781-91. 2009
    Sirtuin 1 (Sirt1) and Sirtuin 2 (Sirt2) belong to the family of NAD+ (nicotinamide adenine dinucleotide-positive)-dependent class III histone deacetylases and are involved in regulating lifespan...
  32. ncbi SIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1{alpha}
    Shino Nemoto
    Cardiovascular Branch, NHLBI, National Institutes of Health, Bethesda, Maryland 20892 1454, USA
    J Biol Chem 280:16456-60. 2005
    ..Here we have examined the cellular effects of overexpression of SIRT1, the closest mammalian ortholog of Sir2...
  33. pmc SIRT1 regulates apoptosis and Nanog expression in mouse embryonic stem cells by controlling p53 subcellular localization
    Myung Kwan Han
    Department of Microbiology and Immunology, Walther Oncology Center, Indiana University School of Medicine, Indianapolis, IN 46202 5181, USA
    Cell Stem Cell 2:241-51. 2008
    ..Although SIRT1, a p53 deacetylase, inhibits p53-mediated transactivation, how SIRT1 regulates these p53 multifunctions is unclear...
  34. pmc The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth
    Ron Firestein
    Paul F Glenn Laboratories for the Biological Mechanisms of Aging, Department of Pathology, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 3:e2020. 2008
    ..The Sir2/SIRT1 family of NAD(+)-dependent deacetylases is proposed to underlie the health benefits of calorie restriction (CR), a ..
  35. pmc Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice
    Hwei Ling Cheng
    Howard Hughes Medical Institute, Children s Hospital, Center for Blood Research, and Department of Genetics, Harvard University Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 100:10794-9. 2003
    b>SIRT1 is a mammalian homolog of the Saccharomyces cerevisiae chromatin silencing factor Sir2...
  36. ncbi SIRT1 improves insulin sensitivity under insulin-resistant conditions by repressing PTP1B
    Cheng Sun
    Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai 200031, China
    Cell Metab 6:307-19. 2007
    ..b>SIRT1 has been reported to be involved in the processes of glucose metabolism and insulin secretion...
  37. pmc Peptide switch is essential for Sirt1 deacetylase activity
    Hyeog Kang
    Laboratory of Obesity and Aging Research, Genetics and Development Biology Center, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Cell 44:203-13. 2011
    In mammals, the Sirtuins are composed of seven Sir2 orthologs (Sirt1-7) with a conserved deacetylase core that utilizes NAD(+) as a cofactor. Interestingly, the deacetylase core of Sirt1 by itself has no catalytic activity...
  38. pmc Heme induced oxidative stress attenuates sirtuin1 and enhances adipogenesis in mesenchymal stem cells and mouse pre-adipocytes
    Nitin Puri
    Department of Physiology and Pharmacology, College of Medicine, The University of Toledo, Toledo, Ohio 43614, USA
    J Cell Biochem 113:1926-35. 2012
    ..In addition, heme exposed 3T3L1 exhibited reduced (P<0.05) expression of transcriptional regulator-sirtuin 1 (Sirt1), along with, increased (P<0...
  39. pmc Enzymes in the NAD+ salvage pathway regulate SIRT1 activity at target gene promoters
    Tong Zhang
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853, USA
    J Biol Chem 284:20408-17. 2009
    ..NAD(+) salvage pathway which regulates the functions of NAD(+)-dependent enzymes such as the protein deacetylase SIRT1. One of the major functions of SIRT1 is to regulate target gene transcription through modification of chromatin-..
  40. pmc Hepatic-specific disruption of SIRT6 in mice results in fatty liver formation due to enhanced glycolysis and triglyceride synthesis
    Hyun Seok Kim
    Genetics of Development and Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Cell Metab 12:224-36. 2010
    Under various conditions, mammals have the ability to maintain serum glucose concentration within a narrow range. SIRT1 plays an important role in regulating gluconeogenesis and fat metabolism; however, the underlying mechanisms remain ..
  41. pmc A pathway involving farnesoid X receptor and small heterodimer partner positively regulates hepatic sirtuin 1 levels via microRNA-34a inhibition
    Jiyoung Lee
    Department of Molecular and Integrative Physiology, University of Illinois, Urbana Champaign, Illinois 61801, USA
    J Biol Chem 285:12604-11. 2010
    Sirtuin 1 (SIRT1) is a NAD-dependent deacetylase that is critically involved in diverse cellular processes including metabolic disease, cancer, and possibly aging...
  42. pmc Sirt1 protects against high-fat diet-induced metabolic damage
    Paul T Pfluger
    Department of Psychiatry, Obesity Research Center, Genome Research Institute, University of Cincinnati College of Medicine, Cincinnati, OH 45237, USA
    Proc Natl Acad Sci U S A 105:9793-8. 2008
    ..Mammalian Sirt1 is a protein deacetylase that has been involved in resveratrol-mediated protection from high-fat diet-induced ..
  43. pmc Tissue-specific regulation of SIRT1 by calorie restriction
    Danica Chen
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Genes Dev 22:1753-7. 2008
    Calorie restriction (CR) has been reported to increase SIRT1 protein levels in mice, rats, and humans, and elevated activity of SIRT1 orthologs extends life span in yeast, worms, and flies...
  44. pmc Disruption of a Sirt1-dependent autophagy checkpoint in the prostate results in prostatic intraepithelial neoplasia lesion formation
    Michael J Powell
    Department of Cancer Biology and Oncology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Cancer Res 71:964-75. 2011
    ..b>SIRT1, the human homologue of the yeast Silent Information Regulator 2 (Sir2) gene, deacetylates histones, p300, p53, ..
  45. ncbi Silent information regulator 2alpha, a longevity factor and class III histone deacetylase, is an essential endogenous apoptosis inhibitor in cardiac myocytes
    Ralph R Alcendor
    Cardiovascular Research Institute, Department of Cell Biology and Molecular Medicine, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark 07103, USA
    Circ Res 95:971-80. 2004
    ..Cardiac myocytes express Sir2alpha predominantly in the nucleus...
  46. doi SirT1-null mice develop tumors at normal rates but are poorly protected by resveratrol
    G Boily
    Center for Cancer Therapeutics, Ottawa Health Research Institute, and Department of Medicine, University of Ottawa, Ontario, Canada
    Oncogene 28:2882-93. 2009
    ..By analogy, SirT1, the mammalian orthologue of Sir2, is a candidate gene to slow down aging and forestall the onset of age-..
  47. pmc Hypothalamic Sirt1 regulates food intake in a rodent model system
    Isin Cakir
    Division of Endocrinology, Department of Medicine, The Warren Alpert Medical School of Brown University Rhode Island Hospital, Providence, Rhode Island, United States of America
    PLoS ONE 4:e8322. 2009
    b>Sirt1 is an evolutionarily conserved NAD(+) dependent deacetylase involved in a wide range of processes including cellular differentiation, apoptosis, as well as metabolism, and aging...
  48. pmc A nutrient-sensitive interaction between Sirt1 and HNF-1α regulates Crp expression
    Andrew A Grimm
    Department of Developmental Biology Department of Genetics, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Aging Cell 10:305-17. 2011
    ..The mammalian Sir2 ortholog Sirt1 regulates metabolic and stress responses through the deacetylation of many transcriptional regulatory factors...
  49. ncbi Increase in activity during calorie restriction requires Sirt1
    Danica Chen
    Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Science 310:1641. 2005
    ..In mammals, calorie restriction induces a complex pattern of physiological and behavioral changes. Here we report that the mammalian Sir2 ortholog, Sirt1, is required for the induction of a phenotype by calorie restriction in mice.
  50. pmc SIRT1 regulates hepatocyte lipid metabolism through activating AMP-activated protein kinase
    Xiuyun Hou
    Vascular Biology Unit and Molecular Cardiology Unit, Whitaker Cardiovascular Institute, Boston University School of Medicine, and Section of Endocrinology, Boston University, Boston, MA 02118, USA
    J Biol Chem 283:20015-26. 2008
    Resveratrol may protect against metabolic disease through activating SIRT1 deacetylase...
  51. pmc The mammalian SIR2alpha protein has a role in embryogenesis and gametogenesis
    Michael W McBurney
    Ottawa Regional Cancer Centre and Department of Medicine, University of Ottawa, Ontario K1H 1C4, Canada
    Mol Cell Biol 23:38-54. 2003
    ..One of these mammalian genes, sir2alpha, is the presumptive mammalian homologue of the yeast sir2 gene...
  52. ncbi SIRT1 deacetylation and repression of p300 involves lysine residues 1020/1024 within the cell cycle regulatory domain 1
    Toula Bouras
    Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, 3970 Reservoir Rd, Washington, DC 20057, USA
    J Biol Chem 280:10264-76. 2005
    ..b>SIRT1, the closest mammalian ortholog of the yeast SIR2 (silent information regulator 2) gene, represses several ..
  53. ncbi The Sirt1 deacetylase modulates the insulin-like growth factor signaling pathway in mammals
    M E Lemieux
    Ottawa Regional Cancer Centre and Department of Medicine, Faculty of Medicine, 501 Smyth Road, University of Ottawa, Ottawa, Canada K1H 1C4
    Mech Ageing Dev 126:1097-105. 2005
    ..The mammalian homologue of SIR2, Sirt1, has been shown to modulate the activity of FoxO, a transcription factor that is downstream of the IGF signaling ..
  54. pmc Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic beta cells
    Laura Bordone
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    PLoS Biol 4:e31. 2006
    ..Here we investigate such a link in mammals. We show that Sirt1 positively regulates insulin secretion in pancreatic beta cells...
  55. pmc SirT1 modulates the estrogen-insulin-like growth factor-1 signaling for postnatal development of mammary gland in mice
    Hongzhe Li
    Department of Radiation Oncology, University of Washington School of Medicine, Seattle, WA 98195, USA
    Breast Cancer Res 9:R1. 2007
    ..b>SirT1 is a highly conserved protein deacetylase that can regulate the insulin/IGF-1 signaling in lower organisms, as ..
  56. pmc Fasting-dependent glucose and lipid metabolic response through hepatic sirtuin 1
    Joseph T Rodgers
    Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 104:12861-6. 2007
    ..We have previously demonstrated that sirtuin 1 (SIRT1) regulates genes involved in gluconeogenesis through interaction and deacetylation of PGC-1alpha...
  57. ncbi The direct involvement of SirT1 in insulin-induced insulin receptor substrate-2 tyrosine phosphorylation
    Jiandi Zhang
    Center for Human Nutrition, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    J Biol Chem 282:34356-64. 2007
    ..The interplay between these two genetic programs is investigated in this study. Protein deacetylase activity of SirT1, the mammalian homologue of Sir2, was suppressed through either nicotinamide treatment or RNA interference in ..
  58. ncbi SIRT1 regulates the histone methyl-transferase SUV39H1 during heterochromatin formation
    Alejandro Vaquero
    Howard Hughes Medical Institute, Division of Nucleic Acids Enzymology, Department of Biochemistry, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, New Jersey 08854, USA
    Nature 450:440-4. 2007
    ..Sirtuin 1 (SIRT1) and suppressor of variegation 3-9 homologue 1 (SUV39H1) are amongst the enzymes responsible for chromatin ..
  59. pmc SIRT1 acts as a nutrient-sensitive growth suppressor and its loss is associated with increased AMPK and telomerase activity
    Swami R Narala
    Ontario Cancer Institute, Department of Medical Biophysics, University of Toronto, Toronto, ON, M5G 2M9, Canada
    Mol Biol Cell 19:1210-9. 2008
    b>SIRT1, the mammalian homolog of SIR2 in Saccharomyces cerevisiae, is an NAD-dependent deacetylase implicated in regulation of lifespan...
  60. doi Protective role of SIRT1 in diabetic vascular dysfunction
    Masayuki Orimo
    Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Arterioscler Thromb Vasc Biol 29:889-94. 2009
    ..b>SIRT1, a mammalian homolog of Sir2, has been reported to downregulate p53 activity and thereby prolong the lifespan of ..
  61. ncbi Predominant expression of Sir2alpha, an NAD-dependent histone deacetylase, in the embryonic mouse heart and brain
    Jun Sakamoto
    Department of Pharmacology, Sapporo Medical University, School of Medicine, S1 W17, Chuo Ku, 060 8556, Sapporo, Japan
    FEBS Lett 556:281-6. 2004
    ..The mammalian homolog Sir2alpha (SIRT1) has been shown to inhibit p53-dependent apoptosis, but its physiological roles are still not known...
  62. ncbi Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase
    Anne Brunet
    Division of Neuroscience, Children s Hospital, and Department of Neurobiology, Center for Blood Research CBR Institute for Biomedical Research, Harvard Medical School, Boston, MA 02115, USA
    Science 303:2011-5. 2004
    ..We show that in mammalian cells, the Sir2 homolog SIRT1 appears to control the cellular response to stress by regulating the FOXO family of Forkhead transcription factors,..
  63. ncbi Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction
    Weiping Qin
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 281:21745-54. 2006
    ..In this study we report for the first time that promotion of the NAD+-dependent sirtuin, SIRT1-mediated deacetylase activity, may be a mechanism by which CR influences Alzheimer disease (AD)-type amyloid ..
  64. ncbi Interactions between E2F1 and SirT1 regulate apoptotic response to DNA damage
    Chuangui Wang
    Molecular Oncology Program, H Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, USA
    Nat Cell Biol 8:1025-31. 2006
    ..The mammalian homologue of Sir2 (SirT1) regulates p53, NF-kappaB and Forkhead transcription factors, and is implicated in stress response...
  65. ncbi SIRT1 regulates adiponectin gene expression through Foxo1-C/enhancer-binding protein alpha transcriptional complex
    Liping Qiao
    Graduate Center for Nutritional Sciences, University of Kentucky, Lexington, Kentucky 40536, USA
    J Biol Chem 281:39915-24. 2006
    ..have indicated that forkhead transcription factor O1 (Foxo1) and silent information regulator 2 mammalian ortholog SIRT1 are involved in adipogenesis...
  66. ncbi SIRT1 modulating compounds from high-throughput screening as anti-inflammatory and insulin-sensitizing agents
    Vasantha M Nayagam
    S BIO Pte Ltd, Singapore
    J Biomol Screen 11:959-67. 2006
    The nicotinamide adenine dinucleotide (NAD(+))-dependent protein deacetylase SIRT1 has been linked to fatty acid metabolism via suppression of peroxysome proliferator-activated receptor gamma (PPAR-gamma) and to inflammatory processes by ..
  67. pmc Adiponectin secretion is regulated by SIRT1 and the endoplasmic reticulum oxidoreductase Ero1-L alpha
    Li Qiang
    Department of Biochemistry, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    Mol Cell Biol 27:4698-707. 2007
    ..Ero1-L alpha and effectors modulating peroxisome proliferator-activated receptor gamma (PPAR gamma) and SIRT1 activities regulate secretion of adiponectin from 3T3-L1 adipocytes...
  68. ncbi SIRT2 deacetylates FOXO3a in response to oxidative stress and caloric restriction
    Fei Wang
    USDA ARS Children s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
    Aging Cell 6:505-14. 2007
    ..The mammalian Sir2 ortholog, SIRT1, is up-regulated by caloric restriction and deacetylates a variety of substrates, including histones and the ..
  69. pmc Sirt1 interacts with transducin-like enhancer of split-1 to inhibit nuclear factor kappaB-mediated transcription
    Hiyaa S Ghosh
    Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Biochem J 408:105-11. 2007
    b>Sirt1 is an NAD+-dependent deacetylase that plays a role in cellular processes such as transcriptional regulation, stress response, longevity and apoptosis...
  70. pmc SIRT1 controls endothelial angiogenic functions during vascular growth
    Michael Potente
    Molecular Cardiology, Department of Internal Medicine III, University of Frankfurt, 60590 Frankfurt, Germany
    Genes Dev 21:2644-58. 2007
    ..Mammalian homologs of Sir2 are called sirtuins (SIRT1-SIRT7)...
  71. pmc Sirt1 deficiency attenuates spermatogenesis and germ cell function
    Matthew Coussens
    John A Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, USA
    PLoS ONE 3:e1571. 2008
    In mammals, Sirt1, a member of the sirtuin family of proteins, functions as a nicotinamide adenine dinucleotide-dependent protein deactylase, and has important physiological roles, including the regulation of glucose metabolism, cell ..
  72. pmc SirT1 regulates energy metabolism and response to caloric restriction in mice
    Gino Boily
    Center for Cancer Therapeutics, Ottawa Health Research Institute, Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada
    PLoS ONE 3:e1759. 2008
    ..We have studied mice carrying two null alleles for SirT1, the mammalian orthologue of sir2, and found that these animals inefficiently utilize ingested food...
  73. doi SIRT1 regulates circadian clock gene expression through PER2 deacetylation
    Gad Asher
    Department of Molecular Biology, Sciences III, University of Geneva, 30, Quai Ernest Ansermet, CH 1211 Geneva 4, Switzerland
    Cell 134:317-28. 2008
    ..Here, we show that SIRT1, an NAD(+)-dependent protein deacetylase, is required for high-magnitude circadian transcription of several core ..
  74. pmc The NAD+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control
    Yasukazu Nakahata
    Department of Pharmacology, University of California, Irvine, CA 92697, USA
    Cell 134:329-40. 2008
    ..We show that the HDAC activity of the NAD(+)-dependent SIRT1 enzyme is regulated in a circadian manner, correlating with rhythmic acetylation of BMAL1 and H3 Lys9/Lys14 at ..
  75. pmc SIRT1 modulation of the acetylation status, cytosolic localization, and activity of LKB1. Possible role in AMP-activated protein kinase activation
    Fan Lan
    Diabetes and Metabolism Research Unit, Department of Medicine, Section of Endocrinology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 283:27628-35. 2008
    b>SIRT1, a histone/protein deacetylase, and AMP-activated protein kinase (AMPK) are key enzymes responsible for longevity and energy homeostasis...
  76. pmc SirT1 gain of function increases energy efficiency and prevents diabetes in mice
    Alexander S Banks
    Naomi Berrie Diabetes Center, Department of Medicine, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Cell Metab 8:333-41. 2008
    ..We generated transgenic mice with moderate overexpression of SirT1, designed to mimic the Sirtuin gain of function that improves metabolism in C. elegans...
  77. pmc A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange
    Yi Liu
    The Salk Institute for Biological Studies, 10010 North Torrey Pines Rd, La Jolla, California 92037, USA
    Nature 456:269-73. 2008
    ..switch, consisting of the histone acetyltransferase p300 and the nutrient-sensing deacetylase sirtuin 1 (SIRT1), maintains energy balance in mice through the sequential induction of CRTC2 and FOXO1...
  78. pmc SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging
    Philipp Oberdoerffer
    Department of Pathology and Glenn Labs for Aging Research, Harvard Medical School, Boston, MA 02115, USA
    Cell 135:907-18. 2008
    ..Using embryonic stem cells, we show that mammalian Sir2, SIRT1, represses repetitive DNA and a functionally diverse set of genes across the mouse genome...
  79. pmc STAT3 inhibition of gluconeogenesis is downregulated by SirT1
    Yongzhan Nie
    Nat Cell Biol 11:492-500. 2009
    The fasting-activated longevity protein sirtuin 1 (SirT1, ref. 1) promotes gluconeogenesis in part, by increasing transcription of the key gluconeogenic genes pepck1 and g6pase, through deacetylating PGC-1alpha and FOXO1 (ref. 4)...
  80. pmc Role of SIRT1 in regulation of LPS- or two ethanol metabolites-induced TNF-alpha production in cultured macrophage cell lines
    Zheng Shen
    Department of Molecular Pharmacology and Physiology, University of South Florida Health Sciences Center, Tampa, Florida 33612, USA
    Am J Physiol Gastrointest Liver Physiol 296:G1047-53. 2009
    ..Sirtuin 1 (SIRT1) is an NAD(+)-dependent class III protein deacetylase that is known to be involved in regulating production of ..
  81. pmc SIRT1 promotes cell survival under stress by deacetylation-dependent deactivation of poly(ADP-ribose) polymerase 1
    Senthilkumar B Rajamohan
    Department of Surgery, University of Chicago, 5841 S Maryland Avenue, Chicago, IL 60637, USA
    Mol Cell Biol 29:4116-29. 2009
    Poly(ADP-ribose) polymerase 1 (PARP1) and SIRT1 deacetylase are two NAD-dependent enzymes which play major roles in the decision of a cell to live or to die in a stress situation...
  82. pmc CK2 is the regulator of SIRT1 substrate-binding affinity, deacetylase activity and cellular response to DNA-damage
    Hyeog Kang
    Laboratory of Biochemical Genetics, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA
    PLoS ONE 4:e6611. 2009
    b>SIRT1, an NAD(+) (nicotinamide adenine dinucleotide)-dependent deacetylase, protects cells from stress-induced apoptosis, and its orthologues delay aging in lower eukaryotes...
  83. doi Regulation of Treg functionality by acetylation-mediated Foxp3 protein stabilization
    Jorg van Loosdregt
    Molecular Immunology Lab, Department of Immunology, Wilhelmina Children s Hospital, Utrecht, The Netherlands
    Blood 115:965-74. 2010
    ..and this can be reciprocally regulated by the histone acetyltransferase p300 and the histone deacetylase SIRT1. Hyperacetylation of Foxp3 prevented polyubiquitination and proteasomal degradation, therefore dramatically ..
  84. pmc SIRT1 inhibits inflammatory pathways in macrophages and modulates insulin sensitivity
    Takeshi Yoshizaki
    Department of Medicine, Univ of California, San Diego, La Jolla, 92037 0673, USA
    Am J Physiol Endocrinol Metab 298:E419-28. 2010
    ..The mammalian silent information regulator 2 homolog SIRT1 modulates several physiological processes important for life span, and a potential role of SIRT1 in the regulation ..
  85. pmc Neuronal SIRT1 regulates endocrine and behavioral responses to calorie restriction
    Dena E Cohen
    Paul F Glenn Laboratory, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Genes Dev 23:2812-7. 2009
    ..b>Sirt1 is a mediator of many effects of CR in mammals, but any role in controlling somatotropic signaling has not been ..
  86. pmc DYRK1A and DYRK3 promote cell survival through phosphorylation and activation of SIRT1
    Xiumei Guo
    Laboratory of Signal Transduction, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 285:13223-32. 2010
    ..pro-survival member of the DYRK family, DYRK3, promote cell survival through phosphorylation and activation of SIRT1, an NAD(+)-dependent protein deacetylase that is essential in a variety of physiological processes including ..
  87. doi Induction of hypothalamic Sirt1 leads to cessation of feeding via agouti-related peptide
    Tsutomu Sasaki
    Metabolic Signal Research Center, Institute for Molecular and Cellular Regulation, Gunma University, 3 39 15 Showa Machi, Maebashi shi, Gunma 371 8512, Japan
    Endocrinology 151:2556-66. 2010
    ..Mammalian Sirt1 is the most closely related homolog of the SIR2 gene...
  88. pmc Shear stress, SIRT1, and vascular homeostasis
    Zhen Chen
    Division of Biomedical Sciences, Biochemistry and Molecular Biology Graduate Program, University of California, Riverside, CA 92521 0121, USA
    Proc Natl Acad Sci U S A 107:10268-73. 2010
    ..We examined the role of shear stress in regulating SIRT1, an NAD(+)-dependent deacetylase, and its functional relevance in vitro and in vivo...
  89. pmc SIRT1 reduces endothelial activation without affecting vascular function in ApoE-/- mice
    Sokrates Stein
    Cardiovascular Research, Institute of Physiology, Zurich Center for Integrative Human Physiology ZIHP, University of Zurich, and Cardiovascular Center, Cardiology, University Hospital Zurich, CH 8057 Zurich, Switzerland
    Aging (Albany NY) 2:353-60. 2010
    ..The class III histone deacetylase SIRT1 has been implicated in extension of lifespan...
  90. pmc SIRT1 deacetylase in POMC neurons is required for homeostatic defenses against diet-induced obesity
    Giorgio Ramadori
    Department of Internal Medicine, Division of Hypothalamic Research, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Cell Metab 12:78-87. 2010
    ..Here we show that lack of nicotinamide adenine dinucleotide (NAD(+))-dependent deacetylase SIRT1 in pro-opiomelanocortin (POMC) neurons causes hypersensitivity to diet-induced obesity due to reduced energy ..
  91. pmc A novel pathway regulates memory and plasticity via SIRT1 and miR-134
    Jun Gao
    Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Nature 466:1105-9. 2010
    ..Its mammalian homologue, SIRT1, seems to have evolved complex systemic roles in cardiac function, DNA repair and genomic stability...
  92. pmc Controlling SIRT1 expression by microRNAs in health and metabolic disease
    Jiyoung Lee
    Department of Molecular and Integrative Physiology, University of Illinois, Urbana Champaign, IL 61801, USA
    Aging (Albany NY) 2:527-34. 2010
    b>SIRT1 is a NAD+-dependent deacetylase implicated in longevity and diverse physiological processes...
  93. pmc Deacetylation of FoxO by Sirt1 Plays an Essential Role in Mediating Starvation-Induced Autophagy in Cardiac Myocytes
    Nirmala Hariharan
    University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Department of Cell Biology and Molecular Medicine, Newark, USA
    Circ Res 107:1470-82. 2010
    ..autophagy, a bulk degradation process of cytosolic proteins and organelles, is protective during nutrient starvation in cardiomyocytes (CMs). However, the underlying signaling mechanism mediating autophagy is not well understood...
  94. pmc Hepatic overexpression of SIRT1 in mice attenuates endoplasmic reticulum stress and insulin resistance in the liver
    Yu Li
    Department of Medicine, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts, 02118, USA
    FASEB J 25:1664-79. 2011
    ..Although SIRT1 has a therapeutic effect on metabolic deterioration in T2DM, the precise mechanisms by which SIRT1 improves ..
  95. pmc SIRT1-mediated acute cardioprotection
    Sergiy M Nadtochiy
    Department of Anesthesiology, University of Rochester Medical Center, Rochester, New York 14642, USA
    Am J Physiol Heart Circ Physiol 301:H1506-12. 2011
    Overexpression studies have revealed a role for silent information regulator of transcription 1 (SIRT1) lysine deacetylase in cardioprotection against ischemia-reperfusion injury via long-term transcriptional effects...
  96. doi Sirt1 is a regulator of bone mass and a repressor of Sost encoding for sclerostin, a bone formation inhibitor
    Einav Cohen-Kfir
    Department of Medicine, Endocrinology and Metabolism Service, Hadassah Hebrew University Medical Center, P O Box 12000, Jerusalem 91120, Israel
    Endocrinology 152:4514-24. 2011
    b>Sirt1, the mammalian ortholog of the yeast Sir2 (silent information regulator 2), was shown to play an important role in metabolism and in age-associated diseases, but its role in skeletal homeostasis and osteoporosis has yet not been ..
  97. doi SirT1 catalytic activity is required for male fertility and metabolic homeostasis in mice
    Erin L Seifert
    Program for Cancer Therapeutics, Ottawa Hospital Research Institute, Otttawa, Ontario, Canada
    FASEB J 26:555-66. 2012
    The protein encoded by the sirt1 gene is an enzyme, SirT1, that couples the hydrolysis of NAD(+) to the deacetylation of acetyl-lysine residues in substrate proteins...
  98. pmc Proatherogenic abnormalities of lipid metabolism in SirT1 transgenic mice are mediated through Creb deacetylation
    Li Qiang
    Naomi Berrie Diabetes Center, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Cell Metab 14:758-67. 2011
    ..Gain of function of the gene encoding deacetylase SirT1 improves insulin sensitivity and could be expected to protect against lipid abnormalities...
  99. pmc Activation of stress response gene SIRT1 by BCR-ABL promotes leukemogenesis
    Hongfeng Yuan
    Department of Cancer Biology, Beckman Research Institute, City of Hope, Duarte, CA, USA
    Blood 119:1904-14. 2012
    ..In the present study, we show that BCR-ABL activates the expression of the mammalian stress response gene SIRT1 in hematopoietic progenitor cells and that this involves STAT5 signaling...
  100. pmc SIRT1 is dispensable for function of hematopoietic stem cells in adult mice
    Vid Leko
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Blood 119:1856-60. 2012
    b>SIRT1 is an NAD(+)-dependent histone deacetylase implicated in the establishment of the primitive hematopoietic system during mouse embryonic development...
  101. pmc Testosterone deficiency accelerates neuronal and vascular aging of SAMP8 mice: protective role of eNOS and SIRT1
    Hidetaka Ota
    Department of Geriatric Medicine, Graduate School of Medicine, University of Tokyo, Bunkyo ku, Tokyo, Japan
    PLoS ONE 7:e29598. 2012
    ..We observed that an NAD(+)-dependent deacetylase, SIRT1, played an important role in the protective effect of testosterone against oxidative stress-induced endothelial ..

Research Grants9

  1. REGULATION OF METALLOTHIONEIN GENE EXPRESSION
    Edward Seto; Fiscal Year: 2002
    ..These studies will be of value not only in understanding the fundamentals of eukaryotic transcriptional regulation, but will also provide additional insights regarding the regulation of a physiologically important gene. ..
  2. Molecular Targets For Cancer Therapy
    Edward Seto; Fiscal Year: 2004
    ..It is anticipated that this conference will not only provide an overview of one of the most important areas in cancer biology, but will foster many collaborative interactions in the future. ..
  3. Mechanisms of Transcription Factor Yin Yang 1
    Edward Seto; Fiscal Year: 2005
    ..abstract_text> ..
  4. Functional Analysis of Histone Deacetylases
    Edward Seto; Fiscal Year: 2006
    ..These studies will ultimately provide important insights critical for a thorough understanding of the intricate mechanisms operating to orchestrate gene expression in mammalian cells. ..
  5. Regulation of Evi-1 function via the corepressor CtBP
    Qinghong Zhang; Fiscal Year: 2006
    ..The mentor's laboratory and institution are rich in intellectual and physical resources that provide an excellent environment for facilitating the principal investigator's transition to independent scientist. ..
  6. Regulation and Functions of Human Histone Deacetylase 8
    Edward Seto; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  7. Regulation of cholesterol catabolism by bile acids
    JONGSOOK KEMPER; Fiscal Year: 2008
    ..abstract_text> ..
  8. Regulation of non-histone protein functions by histone deacetylases
    Edward Seto; Fiscal Year: 2010
    ..Description of changes: The objectives and hypotheses of this revised proposal remain unchanged. As a result, there are minimal changes in this revised abstract section. ..
  9. MOLECULAR REGULATION OF FXR ACTIVITY
    Jongsook Kim Kemper; Fiscal Year: 2010
    ..is to elucidate the role of post-translational acetylation and deacetylation of FXR mediated by p300 and SIRT1 in FXR function in normal physiology and in pathological conditions...