Sipa1

Summary

Gene Symbol: Sipa1
Description: signal-induced proliferation associated gene 1
Alias: Spa1, GTPase-activating protein Spa-1, signal-induced proliferation-associated protein 1, sipa-1
Species: mouse

Top Publications

  1. ncbi Rap1 GTPase-activating protein SPA-1 negatively regulates cell adhesion
    N Tsukamoto
    Department of Immunology and Cell Biology, Graduate School of Medicine, Kyoto University, Kyoto 606 8501, Japan
    J Biol Chem 274:18463-9. 1999
  2. ncbi Human SPA-1 gene product selectively expressed in lymphoid tissues is a specific GTPase-activating protein for Rap1 and Rap2. Segregate expression profiles from a rap1GAP gene product
    H Kurachi
    Department of Immunology and Cell Biology, Graduate School of Medicine, Kyoto University, Kyoto 606, Japan
    J Biol Chem 272:28081-8. 1997
  3. pmc PD-1+ memory phenotype CD4+ T cells expressing C/EBPalpha underlie T cell immunodepression in senescence and leukemia
    Kenichiro Shimatani
    Department of Immunology and Cell Biology, Graduate School of Biostudies, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    Proc Natl Acad Sci U S A 106:15807-12. 2009
  4. ncbi Myeloproliferative stem cell disorders by deregulated Rap1 activation in SPA-1-deficient mice
    Daisuke Ishida
    Department of Immunology and Cell Biology, Graduate School of Biostudies, Kyoto University, 606 8501, Kyoto, Japan
    Cancer Cell 4:55-65. 2003
  5. ncbi Genetic mapping of the galanin-GMAP (Galn) gene to mouse chromosome 19
    L C Guida
    Department of Genetics, Case Western Reserve University, Cleveland, Ohio 44106 4955, USA
    Mamm Genome 9:240-2. 1998
  6. pmc Regulation by afadin of cyclical activation and inactivation of Rap1, Rac1, and RhoA small G proteins at leading edges of moving NIH3T3 cells
    Muneaki Miyata
    Division of Molecular and Cellular Biology, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe, Japan
    J Biol Chem 284:24595-609. 2009
  7. ncbi Bcr/Abl P190 interaction with Spa-1, a GTPase activating protein for the small GTPase Rap1
    Sun Ju Yi
    Section of Molecular Carcinogenesis, The Saban Research Institute of Childrens Hospital, Los Angeles, Los Angeles, CA 90027, USA
    Int J Mol Med 22:453-8. 2008
  8. doi Essential role of Rap signal in pre-TCR-mediated beta-selection checkpoint in alphabeta T-cell development
    Kohei Kometani
    Department of Immunology and Cell Biology, Kyoto University, Kyoto, Japan
    Blood 112:4565-73. 2008
  9. ncbi Role of SPA-1 in phenotypes of chronic myelogenous leukemia induced by BCR-ABL-expressing hematopoietic progenitors in a mouse model
    Kohei Kometani
    Department of Immunology and Cell Biology, Graduate School of Biostudies, Kyoto University
    Cancer Res 66:9967-76. 2006
  10. ncbi Rap1 signal controls B cell receptor repertoire and generation of self-reactive B1a cells
    Daisuke Ishida
    Department of Immunology and Cell Biology, Graduate School of Biostudies, Kyoto University, Kyoto 606 8501, Japan
    Immunity 24:417-27. 2006

Detail Information

Publications18

  1. ncbi Rap1 GTPase-activating protein SPA-1 negatively regulates cell adhesion
    N Tsukamoto
    Department of Immunology and Cell Biology, Graduate School of Medicine, Kyoto University, Kyoto 606 8501, Japan
    J Biol Chem 274:18463-9. 1999
    ..These results have indicated that Rap1 GTP is required for the cell adhesion induced by both extracellular matrix and soluble factors, which is negatively regulated by SPA-1...
  2. ncbi Human SPA-1 gene product selectively expressed in lymphoid tissues is a specific GTPase-activating protein for Rap1 and Rap2. Segregate expression profiles from a rap1GAP gene product
    H Kurachi
    Department of Immunology and Cell Biology, Graduate School of Medicine, Kyoto University, Kyoto 606, Japan
    J Biol Chem 272:28081-8. 1997
    ..These results suggested that products of SPA-1 and rap1GAP genes, albeit comparable GAP activity for Rap1 and Rap2, functioned in the distinct contexts depending on cell types and/or states...
  3. pmc PD-1+ memory phenotype CD4+ T cells expressing C/EBPalpha underlie T cell immunodepression in senescence and leukemia
    Kenichiro Shimatani
    Department of Immunology and Cell Biology, Graduate School of Biostudies, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    Proc Natl Acad Sci U S A 106:15807-12. 2009
    ..The results suggest that global T cell immunodepression in senescence and leukemia is attributable to the increase in PD-1(+) MP CD4(+) T cells expressing C/EBPalpha...
  4. ncbi Myeloproliferative stem cell disorders by deregulated Rap1 activation in SPA-1-deficient mice
    Daisuke Ishida
    Department of Immunology and Cell Biology, Graduate School of Biostudies, Kyoto University, 606 8501, Kyoto, Japan
    Cancer Cell 4:55-65. 2003
    ..These results unveiled a role of Rap1 in myeloproliferative stem cell disorders and a tumor suppressor function of SPA-1...
  5. ncbi Genetic mapping of the galanin-GMAP (Galn) gene to mouse chromosome 19
    L C Guida
    Department of Genetics, Case Western Reserve University, Cleveland, Ohio 44106 4955, USA
    Mamm Genome 9:240-2. 1998
  6. pmc Regulation by afadin of cyclical activation and inactivation of Rap1, Rac1, and RhoA small G proteins at leading edges of moving NIH3T3 cells
    Muneaki Miyata
    Division of Molecular and Cellular Biology, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe, Japan
    J Biol Chem 284:24595-609. 2009
    ..These results indicate that afadin regulates the cyclical activation and inactivation of Rap1, Rac1, and RhoA through SPA-1 and ARAP1...
  7. ncbi Bcr/Abl P190 interaction with Spa-1, a GTPase activating protein for the small GTPase Rap1
    Sun Ju Yi
    Section of Molecular Carcinogenesis, The Saban Research Institute of Childrens Hospital, Los Angeles, Los Angeles, CA 90027, USA
    Int J Mol Med 22:453-8. 2008
    ..The binding of Bcr/Abl to Spa-1 may cause aberrant subcellular location of Spa-1 and affect migration of these cells...
  8. doi Essential role of Rap signal in pre-TCR-mediated beta-selection checkpoint in alphabeta T-cell development
    Kohei Kometani
    Department of Immunology and Cell Biology, Kyoto University, Kyoto, Japan
    Blood 112:4565-73. 2008
    ..These results suggest that endogenous Rap GTPases downstream of pre-TCR play an essential role in rescuing pre-T cells from the p53-mediated checkpoint response, thus allowing Notch-mediated expansion and differentiation...
  9. ncbi Role of SPA-1 in phenotypes of chronic myelogenous leukemia induced by BCR-ABL-expressing hematopoietic progenitors in a mouse model
    Kohei Kometani
    Department of Immunology and Cell Biology, Graduate School of Biostudies, Kyoto University
    Cancer Res 66:9967-76. 2006
    ....
  10. ncbi Rap1 signal controls B cell receptor repertoire and generation of self-reactive B1a cells
    Daisuke Ishida
    Department of Immunology and Cell Biology, Graduate School of Biostudies, Kyoto University, Kyoto 606 8501, Japan
    Immunity 24:417-27. 2006
    ..Present results suggest that the regulated Rap1 signal in the immature B cells plays a role in modifying the B cell receptor repertoire and in maintaining the self-tolerance...
  11. pmc Sipa1 is a candidate for underlying the metastasis efficiency modifier locus Mtes1
    Yeong Gwan Park
    Laboratory of Population Genetics, National Cancer Institute, Building 41, Room 702, 41 Library Drive, Bethesda, Maryland 20892, USA
    Nat Genet 37:1055-62. 2005
    ..Here, we present data supporting the idea that the signal transduction molecule, Sipa1, is a candidate for underlying the metastasis efficiency modifier locus Mtes1...
  12. pmc Antigen-driven T cell anergy and defective memory T cell response via deregulated Rap1 activation in SPA-1-deficient mice
    Daisuke Ishida
    Department of Immunology and Cell Biology, Graduate School of Biostudies, Kyoto University, Japan
    Proc Natl Acad Sci U S A 100:10919-24. 2003
    ....
  13. ncbi Mitogen-inducible SIPA1 is mapped to the conserved syntenic groups of chromosome 19 in mouse and chromosome 11q13.3 centromeric to BCL1 in human
    Y Wada
    Department of Immunology and Cell Biology, Graduate School of Medicine, Kyoto University, Japan
    Genomics 39:66-73. 1997
    b>Sipa1, previously called Spa1, is transcriptionally induced in the murine lymphoid cells following mitogenic stimulation and encodes a protein with a domain related to Rap1 GTPase activating protein (Rap1GAP) at the N-terminus and to ..
  14. ncbi SPAL, a Rap-specific GTPase activating protein, is present in the NMDA receptor-PSD-95 complex in the hippocampus
    Badal C Roy
    Laboratory of Molecular and Genetic Information, Institute for Molecular and Cellular Biosciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113, Japan
    Genes Cells 7:607-17. 2002
    ..The PSD-95 proteins function as scaffolding proteins that link ion channels such as the N-methyl-d-aspartate-receptors (NMDA-Rs) with cytoskeletal networks and signalling molecules, thereby controlling synaptic plasticity and learning...
  15. ncbi Genomic sequencing reveals the structure of the Kcnk6 and map3k11 genes and their close vicinity to the sipa1 gene on mouse chromosome 19
    A Saridaki
    Institute of Human Genetics and Anthropology, University of Freiburg, Freiburg, Germany
    Cytogenet Cell Genet 89:85-8. 2000
    ..overlapping mouse cosmid clones that contain the entire Kcnk6, Map3k11 and Pcnxl3 genes, as well as part of the Sipa1 gene. The sequence and genomic organisation of the Kcnk6 and Map3k11 genes are described in detail...
  16. ncbi [Regulatory mechanisms of lymphocyte proliferation: roles of Spa-1 gene]
    N Minato
    Department of Immunology and Cell Biology, Faculty of Medicine, Kyoto University, Japan
    Hum Cell 9:11-6. 1996
    ..Analysis of this mechanism may provide a new insight into the transformation processes in lymphoid cells...
  17. ncbi Genomic organization and cloning of the human homologue of murine Sipa-1
    S Ebrahimi
    UCLA School of Medicine, West Los Angeles VA Medical Center Department of Surgery Core Molecular Biology Unit, 10833 Le, Conte Ave 72 215 CHS, Los Angeles, CA 90095 6904, USA
    Gene 214:215-21. 1998
    ..It is widely expressed, including in fetal tissues, but is most highly expressed in lymphoid organs. During the course of cloning SIPA-1, the MEN1 gene was identified, thus excluding human SIPA-1 as a candidate for this disease...
  18. pmc Molecular cloning of a novel mitogen-inducible nuclear protein with a Ran GTPase-activating domain that affects cell cycle progression
    M Hattori
    Department of Immunology and Cell Biology, Faculty of Medicine, Kyoto University, Japan
    Mol Cell Biol 15:552-60. 1995
    ..Functions of the Spa-1 protein and its regulation are discussed in the context of its possible interaction with the Ran/RCC-1 system, which is involved in the coordinated nuclear functions, including cell division...