Sh3gl1

Summary

Gene Symbol: Sh3gl1
Description: SH3-domain GRB2-like 1
Alias: C77078, EEN, SH3P8, Sh3d2b, endophilin-A2, SH3 domain protein 2B, SH3 domain-containing GRB2-like protein 1, endophilin II, endophilin-2
Species: mouse

Top Publications

  1. ncbi Endophilin A2 Influences Volume-Regulated Chloride Current by Mediating ClC-3 Trafficking in Vascular Smooth Muscle Cells
    Can Zhao Liu
    Department of Pharmacology, Zhongshan School of Medicine, Sun Yat Sen University
    Circ J 80:2397-2406. 2016
  2. pmc Upregulation of Parkin in endophilin mutant mice
    Mian Cao
    Department of Cell Biology, Howard Hughes Medical Institute and Program in Cellular Neuroscience, Neurodegeneration and Repair, Yale University School of Medicine, New Haven, Connecticut 06510
    J Neurosci 34:16544-9. 2014
  3. ncbi Alix (ALG-2-interacting protein X), a protein involved in apoptosis, binds to endophilins and induces cytoplasmic vacuolization
    Christine Chatellard-Causse
    Laboratoire Neurodégénérescence et Plasticité, INSERM UJF EMI 0108, Hopital A Michallon, CHU, BP 217, 38043 Grenoble Cedex 9, France
    J Biol Chem 277:29108-15. 2002
  4. pmc Function of focal adhesion kinase scaffolding to mediate endophilin A2 phosphorylation promotes epithelial-mesenchymal transition and mammary cancer stem cell activities in vivo
    Huaping Fan
    Division of Molecular Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109 2200, USA
    J Biol Chem 288:3322-33. 2013
  5. pmc Role of dynamin, synaptojanin, and endophilin in podocyte foot processes
    Keita Soda
    Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA
    J Clin Invest 122:4401-11. 2012
  6. pmc Single point mutation in Bin/Amphiphysin/Rvs (BAR) sequence of endophilin impairs dimerization, membrane shaping, and Src homology 3 domain-mediated partnership
    Anna Gortat
    CNRS, UMR7592, Institut Jacques Monod, Universite Paris Diderot, Sorbonne Paris Cité, F 75205 Paris, France
    J Biol Chem 287:4232-47. 2012
  7. pmc Recruitment of endophilin to clathrin-coated pit necks is required for efficient vesicle uncoating after fission
    Ira Milosevic
    Department of Cell Biology, Howard Hughes Medical Institute, Program in Cellular Neuroscience, Neurodegeneration, and Repair, Kavli Institute for Neuroscience, Yale University School of Medicine, New Haven, CT 06519, USA
    Neuron 72:587-601. 2011
  8. pmc Proteomic analysis of optic nerve lipid rafts reveals new paranodal proteins
    Yasuhiro Ogawa
    Department of Neuroscience, Baylor College of Medicine, Houston, Texas, USA
    J Neurosci Res 87:3502-10. 2009
  9. doi Ubiquitin-like protein MNSFβ/endophilin II complex regulates Dectin-1-mediated phagocytosis and inflammatory responses in macrophages
    Morihiko Nakamura
    Department of Cooperative Medical Research, Collaboration Center, Shimane University, Izumo 693 8501, Japan
    Biochem Biophys Res Commun 401:257-61. 2010
  10. doi SH3 domains from a subset of BAR proteins define a Ubl-binding domain and implicate parkin in synaptic ubiquitination
    Jean Francois Trempe
    Department of Biochemistry, McGill University, Montreal, Quebec, Canada
    Mol Cell 36:1034-47. 2009

Scientific Experts

  • Ira Milosevic
  • Morihiko Nakamura
  • Silvia Giovedi
  • Pietro De Camilli
  • Can Zhao Liu
  • Mian Cao
  • Huaping Fan
  • Keita Soda
  • Anna Gortat
  • Summer Paradise
  • Ottavio Cremona
  • Yasuhiro Ogawa
  • Jean Francois Trempe
  • Anne A Schmidt
  • C T Kong
  • Xiaolong Yin
  • Jan Modregger
  • Ren Hong Du
  • Guan Lei Wang
  • Hong Shuo Sun
  • Fei Ya Li
  • Er Wen Huang
  • Min Gao
  • Ming Ming Ma
  • L C Chan
  • M H Sham
  • Yong Yuan Guan
  • Xiang Yu Li
  • Christine Chatellard-Causse
  • Jun Lin Guan
  • Ming Luo
  • Xiaofeng Zhao
  • Shaogang Sun
  • Yumei Wu
  • Mabel Jouve San-Roman
  • Daniel M Balkin
  • Shuta Ishibe
  • Lawrence B Holzman
  • Rena Zheng
  • Christian Vannier
  • Sung Hyun Son
  • Laura Volpicelli-Daley
  • Shawn M Ferguson
  • Xuefei Tian
  • Gilbert Moeckel
  • Hong Ma
  • Shawn Ferguson
  • EILEEN O'TOOLE
  • Hongying Shen
  • Andrea Raimondi
  • Chiara Collesi
  • Xuelin Lou
  • Natsuko Watanabe
  • C W So
  • Peter S McPherson
  • Carol X Q Chen
  • Guennadi Kozlov
  • Shunsuke Shimosaki
  • Karl Grenier
  • Edna Matta Camacho
  • Edward A Fon
  • B K Kay
  • Kalle Gehring
  • Matthew N Rasband
  • A B Sparks
  • N G Hoffman
  • C W E So
  • T Torrey
  • K S E Cheah
  • S J Chen
  • Emily A Roberts
  • Robert M Greene
  • M Michele Pisano
  • Dennis R Warner
  • K D Micheva
  • Wieland B Huttner
  • Brigitte Ritter
  • Markus Plomann
  • Nadine Cristina
  • Sakina Torch
  • Beatrice Blot
  • Remy Sadoul
  • Marc Missotten
  • S L Chew
  • C Caldas
  • C K So
  • L M Wiedemann
  • S K Chung
  • N Cheung
  • C A Kozak

Detail Information

Publications19

  1. ncbi Endophilin A2 Influences Volume-Regulated Chloride Current by Mediating ClC-3 Trafficking in Vascular Smooth Muscle Cells
    Can Zhao Liu
    Department of Pharmacology, Zhongshan School of Medicine, Sun Yat Sen University
    Circ J 80:2397-2406. 2016
    ..Live cell imaging was used to observe ClC-3 transporting. The results showed that an overexpression of endophilin A2 could increaseICl.vol, while endophilin A2 knockdown decreasedICl.vol...
  2. pmc Upregulation of Parkin in endophilin mutant mice
    Mian Cao
    Department of Cell Biology, Howard Hughes Medical Institute and Program in Cellular Neuroscience, Neurodegeneration and Repair, Yale University School of Medicine, New Haven, Connecticut 06510
    J Neurosci 34:16544-9. 2014
    ....
  3. ncbi Alix (ALG-2-interacting protein X), a protein involved in apoptosis, binds to endophilins and induces cytoplasmic vacuolization
    Christine Chatellard-Causse
    Laboratoire Neurodégénérescence et Plasticité, INSERM UJF EMI 0108, Hopital A Michallon, CHU, BP 217, 38043 Grenoble Cedex 9, France
    J Biol Chem 277:29108-15. 2002
    ..Using Alix as bait in a yeast two-hybrid system to screen a mouse brain library, we have found that SH3p4, SH3p8, and SH3p13, collectively known as endophilins, bind to Alix...
  4. pmc Function of focal adhesion kinase scaffolding to mediate endophilin A2 phosphorylation promotes epithelial-mesenchymal transition and mammary cancer stem cell activities in vivo
    Huaping Fan
    Division of Molecular Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109 2200, USA
    J Biol Chem 288:3322-33. 2013
    ..This mutation disrupted the function of FAK scaffolding to mediate endophilin A2 phosphorylation at Tyr-315 by Src, leading to the decreased surface expression of MT1-MMP, as observed ..
  5. pmc Role of dynamin, synaptojanin, and endophilin in podocyte foot processes
    Keita Soda
    Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA
    J Clin Invest 122:4401-11. 2012
    ..In addition, we demonstrated that while synaptojanin 1 (Synj1) KO mice and endophilin 1 (Sh3gl2), endophilin 2 (Sh3gl1), and endophilin 3 (Sh3gl3) triple-KO mice had grossly normal embryonic development, these mutants ..
  6. pmc Single point mutation in Bin/Amphiphysin/Rvs (BAR) sequence of endophilin impairs dimerization, membrane shaping, and Src homology 3 domain-mediated partnership
    Anna Gortat
    CNRS, UMR7592, Institut Jacques Monod, Universite Paris Diderot, Sorbonne Paris Cité, F 75205 Paris, France
    J Biol Chem 287:4232-47. 2012
    ..In comparison with wild type, full-length endophilin A2 heterodimers with one protomer bearing the L215D substitution exhibit very significant changes in membrane ..
  7. pmc Recruitment of endophilin to clathrin-coated pit necks is required for efficient vesicle uncoating after fission
    Ira Milosevic
    Department of Cell Biology, Howard Hughes Medical Institute, Program in Cellular Neuroscience, Neurodegeneration, and Repair, Kavli Institute for Neuroscience, Yale University School of Medicine, New Haven, CT 06519, USA
    Neuron 72:587-601. 2011
    ....
  8. pmc Proteomic analysis of optic nerve lipid rafts reveals new paranodal proteins
    Yasuhiro Ogawa
    Department of Neuroscience, Baylor College of Medicine, Houston, Texas, USA
    J Neurosci Res 87:3502-10. 2009
    ..Further analysis based on antibody staining of central and peripheral nerves revealed beta-adducin, septin 2, and sh3p8 as putative paranodal proteins...
  9. doi Ubiquitin-like protein MNSFβ/endophilin II complex regulates Dectin-1-mediated phagocytosis and inflammatory responses in macrophages
    Morihiko Nakamura
    Department of Cooperative Medical Research, Collaboration Center, Shimane University, Izumo 693 8501, Japan
    Biochem Biophys Res Commun 401:257-61. 2010
    ..Most recently, we found that MNSFβ covalently conjugates to endophilin II, a member of the endophilin A family, and inhibits phagocytosis by macrophages...
  10. doi SH3 domains from a subset of BAR proteins define a Ubl-binding domain and implicate parkin in synaptic ubiquitination
    Jean Francois Trempe
    Department of Biochemistry, McGill University, Montreal, Quebec, Canada
    Mol Cell 36:1034-47. 2009
    ..The findings identify a pathway for the recruitment of synaptic substrates to parkin with the potential to explain the defects in synaptic transmission observed in recessive forms of PD...
  11. doi The ubiquitin-like protein monoclonal nonspecific suppressor factor beta conjugates to endophilin II and regulates phagocytosis
    Morihiko Nakamura
    Department of Cooperative Medical Research, Collaboration Center, Shimane University, Izumo 693 8501, Japan
    FEBS J 276:6355-63. 2009
    ..MALDI-TOF MS fingerprinting revealed that this MNSFbeta adduct consists of an 8.5 kDa MNSFbeta and endophilin II, a member of the endophilin A family...
  12. ncbi Binding properties of SH3 peptide ligands identified from phage-displayed random peptide libraries
    N G Hoffman
    Department of Biology, University of North Carolina, Chapel Hill 27599 3280, USA
    Mol Divers 2:5-12. 1996
    ....
  13. ncbi The Mll-Een knockin fusion gene enhances proliferation of myeloid progenitors derived from mouse embryonic stem cells and causes myeloid leukaemia in chimeric mice
    C T Kong
    SH Ho Foundation Research Laboratories in the Department of Pathology, Hong Kong Jockey Club Clinical Research Centre, Hong Kong SAR, China
    Leukemia 20:1829-39. 2006
    Rearrangement of the mixed lineage leukaemia (MLL) gene with extra eleven nineteen (EEN) was previously identified in an infant with acute myeloid leukaemia...
  14. ncbi Identification of novel CBP interacting proteins in embryonic orofacial tissue
    Xiaolong Yin
    Department of Molecular, Cellular and Craniofacial Biology, University of Louisville Birth Defects Center, ULSD Louisville, KY 40292, USA
    Biochem Biophys Res Commun 329:1010-7. 2005
    ..The identification of these proteins as novel CBP-binding partners allows exploration of new mechanisms by which CBP regulates and integrates diverse cell signaling pathways...
  15. ncbi Characterization of Endophilin B1b, a brain-specific membrane-associated lysophosphatidic acid acyl transferase with properties distinct from endophilin A1
    Jan Modregger
    Center for Biochemistry II, Medical Faculty, Joseph Stelzmann Strasse 52, University of Cologne, Germany
    J Biol Chem 278:4160-7. 2003
    ....
  16. pmc Expression and protein-binding studies of the EEN gene family, new interacting partners for dynamin, synaptojanin and huntingtin proteins
    C W So
    Department of Pathology, The University of Hong Kong, Hong Kong, Peoples Republic of China
    Biochem J 348:447-58. 2000
    b>EEN, identified initially as a fusion partner to the mixed-lineage leukaemia gene in human leukaemia, and its related members, EEN-B1 and EEN-B2, have recently been shown to interact with two endocytic molecules, dynamin and synaptojanin,..
  17. ncbi Cloning of ligand targets: systematic isolation of SH3 domain-containing proteins
    A B Sparks
    Department of Biology, University of North Carolina, Chapel Hill 27599, USA
    Nat Biotechnol 14:741-4. 1996
    ..The isolation of entire repertoires of modular domain-containing proteins will prove invaluable in genome analysis and in bringing new targets into drug discovery programs...
  18. ncbi Cloning, expression and genetic mapping of the mouse SH3 domain protein, SH3D2B
    T Torrey
    Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institute of Health, Bethesda, Maryland 20892, USA
    Mamm Genome 9:74-5. 1998
  19. ncbi Synaptojanin forms two separate complexes in the nerve terminal. Interactions with endophilin and amphiphysin
    K D Micheva
    Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, 3801 rue University, Montreal, Quebec H3A 2B4, Canada
    J Biol Chem 272:27239-45. 1997
    ..These data demonstrate that synaptojanin is present in two separate complexes in the nerve terminal and support an important role for endophilin in the regulation of synaptojanin function...