Sftpc

Summary

Gene Symbol: Sftpc
Description: surfactant associated protein C
Alias: Bricd6, SP-C, SP5, SPC, Sftp-2, Sftp2, pro-SpC, pulmonary surfactant-associated protein C, pulmonary surfactant-associated proteolipid SPL(Val)
Species: mouse

Top Publications

  1. ncbi Structure and expression of the pulmonary surfactant protein SP-C gene in the mouse
    S W Glasser
    Division of Neonatology, University of Cincinnati College of Medicine, Ohio
    J Biol Chem 265:21986-91. 1990
  2. ncbi Nkx3.1, a murine homolog of Ddrosophila bagpipe, regulates epithelial ductal branching and proliferation of the prostate and palatine glands
    M Tanaka
    Cardiovascular Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Dev Dyn 219:248-60. 2000
  3. ncbi Lung hypoplasia and neonatal death in Fgf9-null mice identify this gene as an essential regulator of lung mesenchyme
    J S Colvin
    Department of Molecular Biology and Pharmacology, Washington University Medical School, Campus Box 8103, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Development 128:2095-106. 2001
  4. ncbi Wnt5a participates in distal lung morphogenesis
    Changgong Li
    Department of Pediatrics, Women s and Children s Hospital, Los Angeles, CA 90033, USA
    Dev Biol 248:68-81. 2002
  5. ncbi beta-Catenin is required for specification of proximal/distal cell fate during lung morphogenesis
    Michael L Mucenski
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    J Biol Chem 278:40231-8. 2003
  6. pmc Foxp2 inhibits Nkx2.1-mediated transcription of SP-C via interactions with the Nkx2.1 homeodomain
    Beiyun Zhou
    Will Rogers Institute Pulmonary Research Center, Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Southern California, 2020 Zonal Avenue, Los Angeles, CA 90033, USA
    Am J Respir Cell Mol Biol 38:750-8. 2008
  7. pmc The divergent roles of secreted frizzled related protein-1 (SFRP1) in lung morphogenesis and emphysema
    Robert Foronjy
    Department of Medicine, Columbia University, New York, New York, USA
    Am J Pathol 177:598-607. 2010
  8. ncbi FGF-1 and FGF-7 induce distinct patterns of growth and differentiation in embryonic lung epithelium
    W V Cardoso
    The Pulmonary Center, Department of Medicine, Boston University School of Medicine, Massachusetts 02118, USA
    Dev Dyn 208:398-405. 1997
  9. pmc Eyes absent 1 (Eya1) is a critical coordinator of epithelial, mesenchymal and vascular morphogenesis in the mammalian lung
    Ahmed H K El-Hashash
    Developmental Biology and Regenerative Medicine Program, Saban Research Institute, Childrens Hospital Los Angeles, Keck School of Medicine of University of Southern California, 4650 Sunset Boulevard MS35, Los Angeles, CA 90027, USA
    Dev Biol 350:112-26. 2011
  10. ncbi TAZ interacts with TTF-1 and regulates expression of surfactant protein-C
    Kwon Sik Park
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    J Biol Chem 279:17384-90. 2004

Research Grants

  1. Excess TGF beta in neonatal lung injury and repair
    David Warburton; Fiscal Year: 2004
  2. Lung epithelial and vascular morphogenesis
    David Warburton; Fiscal Year: 2006
  3. AUTOCRINE/PARACRINE GROWTH FACTORS & LUNG MORPHOGENESIS
    David Warburton; Fiscal Year: 2009
  4. DEVELOPMENTAL TYPE II PNEUMOCYTE PROTEIN PHOSPHORYLATION
    David Warburton; Fiscal Year: 2010
  5. CYSTEINE PROTEASES IN MHC CLASS II ANTIGEN PRESENTATION
    Harold Chapman; Fiscal Year: 2007
  6. PLASMIN, FIBRIN, AND METALLOPROTEINASES IN LUNG FIBROSIS
    Thomas Sisson; Fiscal Year: 2004
  7. BR22, A Novel Protein Interacting with TTF-1
    Yih Sheng Yang; Fiscal Year: 2005
  8. Role of NFI in type II Cell Function
    CINDY BACHURSKI; Fiscal Year: 2006
  9. Interactive Mediators of Injury & Development
    Parviz Minoo; Fiscal Year: 2008
  10. Fetal Lung Development:Role of Wnt5a Signaling
    Changgong Li; Fiscal Year: 2008

Scientific Experts

Detail Information

Publications121 found, 100 shown here

  1. ncbi Structure and expression of the pulmonary surfactant protein SP-C gene in the mouse
    S W Glasser
    Division of Neonatology, University of Cincinnati College of Medicine, Ohio
    J Biol Chem 265:21986-91. 1990
    ..The shared structural organization and developmental and tissue-specific expression of the SP-C gene between the mouse and human demonstrate considerable phylogenetic conservation of this gene and protein...
  2. ncbi Nkx3.1, a murine homolog of Ddrosophila bagpipe, regulates epithelial ductal branching and proliferation of the prostate and palatine glands
    M Tanaka
    Cardiovascular Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Dev Dyn 219:248-60. 2000
    ..However, we did not observe prostate cancer in homozygous mutant mice up to 2 years of age. Therefore, involvement of NKX3.1 in carcinogenesis in men needs to be carefully determined by further investigation...
  3. ncbi Lung hypoplasia and neonatal death in Fgf9-null mice identify this gene as an essential regulator of lung mesenchyme
    J S Colvin
    Department of Molecular Biology and Pharmacology, Washington University Medical School, Campus Box 8103, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Development 128:2095-106. 2001
    ..We suggest a model whereby FGF9 signaling from the epithelium and reciprocal FGF10 signaling from the mesenchyme coordinately regulate epithelial airway branching and organ size during lung embryogenesis...
  4. ncbi Wnt5a participates in distal lung morphogenesis
    Changgong Li
    Department of Pediatrics, Women s and Children s Hospital, Los Angeles, CA 90033, USA
    Dev Biol 248:68-81. 2002
    ..Absence of WNT5a activity in the mutant lungs leads to increased expression of Fgf-10, Bmp4, Shh, and its receptor Ptc, raising the possibility that WNT5a, FGF-10, BMP4, and SHH signaling pathways are functionally interactive...
  5. ncbi beta-Catenin is required for specification of proximal/distal cell fate during lung morphogenesis
    Michael L Mucenski
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    J Biol Chem 278:40231-8. 2003
    ..These observations establish, for the first time, both the sites and timing of specification of the proximal and peripheral airways in the developing lung, and that beta-catenin is one of the essential components of this specification...
  6. pmc Foxp2 inhibits Nkx2.1-mediated transcription of SP-C via interactions with the Nkx2.1 homeodomain
    Beiyun Zhou
    Will Rogers Institute Pulmonary Research Center, Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Southern California, 2020 Zonal Avenue, Los Angeles, CA 90033, USA
    Am J Respir Cell Mol Biol 38:750-8. 2008
    ..1 inhibits Nkx2.1 DNA-binding and transcriptional activity and suggest a mechanism for down-regulation of SP-C (and probably other AT2 cell genes) during transition of AT2 cells to an AT1 cell phenotype...
  7. pmc The divergent roles of secreted frizzled related protein-1 (SFRP1) in lung morphogenesis and emphysema
    Robert Foronjy
    Department of Medicine, Columbia University, New York, New York, USA
    Am J Pathol 177:598-607. 2010
    ..Thus, SFRP1 induction during tissue injury is unlikely to contribute to the repair response but rather is a participatory factor in the pathogenesis of emphysema and tissue destruction...
  8. ncbi FGF-1 and FGF-7 induce distinct patterns of growth and differentiation in embryonic lung epithelium
    W V Cardoso
    The Pulmonary Center, Department of Medicine, Boston University School of Medicine, Massachusetts 02118, USA
    Dev Dyn 208:398-405. 1997
    ..Thus, in the embryonic lung epithelium, growth effects of FGFs appear to be dependent on location of FGFRs, while effects on differentiation are ligand-dependent...
  9. pmc Eyes absent 1 (Eya1) is a critical coordinator of epithelial, mesenchymal and vascular morphogenesis in the mammalian lung
    Ahmed H K El-Hashash
    Developmental Biology and Regenerative Medicine Program, Saban Research Institute, Childrens Hospital Los Angeles, Keck School of Medicine of University of Southern California, 4650 Sunset Boulevard MS35, Los Angeles, CA 90027, USA
    Dev Biol 350:112-26. 2011
    ..We conclude, therefore, that Eya1 function is critical for proper coordination of lung epithelial, mesenchymal and vascular development...
  10. ncbi TAZ interacts with TTF-1 and regulates expression of surfactant protein-C
    Kwon Sik Park
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    J Biol Chem 279:17384-90. 2004
    ..TAZ binds to TTF-1, increasing the transcriptional activity of TTF-1 on the SP-C promoter. Developmental and cell-selective regulation of TAZ provides a mechanism by which the activity of TTF-1 on target genes is modulated...
  11. ncbi Temporal-spatial expression and transcriptional regulation of alpha7 nicotinic acetylcholine receptor by thyroid transcription factor-1 and early growth response factor-1 during murine lung development
    Paul R Reynolds
    Department of Internal Medicine, Pulmonary Division, University of Utah Health Sciences Center, Salt Lake City, 84132, USA
    J Biol Chem 280:32548-54. 2005
    ..A model is also supported whereby alpha(7) is induced by the essential pulmonary transcription factor TTF-1 and suppressed by Egr-1 during pulmonary development...
  12. ncbi The TTF-1/TAP26 complex differentially modulates surfactant protein-B (SP-B) and -C (SP-C) promoters in lung cells
    Meng Chun Yang
    Department of Internal Medicine, Pulmonary and Critical Care Medicine, UT Southwestern Medical Center, Dallas, TX 75390 9034, USA
    Biochem Biophys Res Commun 344:484-90. 2006
    ..Thus, a dimerized complex structure was needed for advanced promoter activity. This result also provided a molecular mechanism by which both the SP-B and SP-C promoters could be differentially regulated by the same complex...
  13. ncbi Sequence, ontogeny, and cellular localization of murine surfactant protein B mRNA
    M A D'Amore-Bruno
    Division of Pulmonary Biology, Children s Hospital Medical Center, Cincinnati, Ohio 45229
    Am J Physiol 262:L40-7. 1992
    ..The murine SP-B mRNA was expressed in proximal and distal epithelial cells within the respiratory tract and shares a close structural relationship to SP-B from other species...
  14. ncbi Targeted disruption of the glucocorticoid receptor gene blocks adrenergic chromaffin cell development and severely retards lung maturation
    T J Cole
    Division of Molecular Biology of the Cell I, German Cancer Research Center, Heidelberg
    Genes Dev 9:1608-21. 1995
    ....
  15. pmc Targeted disruption of the surfactant protein B gene disrupts surfactant homeostasis, causing respiratory failure in newborn mice
    J C Clark
    Division of Pulmonary Biology, Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    Proc Natl Acad Sci U S A 92:7794-8. 1995
    ..Ablation of the SP-B gene disrupts the routing, storage, and function of surfactant phospholipids and proteins, causing respiratory failure at birth...
  16. ncbi Involvement of Sonic hedgehog (Shh) in mouse embryonic lung growth and morphogenesis
    S Bellusci
    Department of Cell Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2175, USA
    Development 124:53-63. 1997
    ..By contrast, Ptc is clearly upregulated in the transgenic lung. These results thus establish a role for SHH in lung morphogenesis, and suggest that SHH normally regulates lung mesenchymal cell proliferation in vivo...
  17. ncbi Sonic hedgehog regulates branching morphogenesis in the mammalian lung
    C V Pepicelli
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Curr Biol 8:1083-6. 1998
    ..In addition, the transcription of several mesenchymally expressed downstream targets of Shh is abolished. These results highlight the importance of epithelially derived Shh in regulating branching morphogenesis of the lung...
  18. ncbi Defects in tracheoesophageal and lung morphogenesis in Nkx2.1(-/-) mouse embryos
    P Minoo
    Department of Pediatrics, Women s and Children s Hospital, Los Angeles, California 90033, USA
    Dev Biol 209:60-71. 1999
    ..These results demonstrate a critical role for Nkx2.1 in morphogenesis of the anterior foregut and the lung as well as in differentiation of pulmonary epithelial cells...
  19. ncbi Bmp signaling regulates proximal-distal differentiation of endoderm in mouse lung development
    M Weaver
    Howard Hughes Medical Institute, Department of Cell Biology, Nashville, TN, USA
    Development 126:4005-15. 1999
    ..Endodermal cells at the periphery of the lung, which are exposed to high levels of Bmp4, maintain or adopt a distal character, while cells receiving little or no Bmp4 signal initiate a proximal differentiation program...
  20. ncbi The basic-helix-loop-helix protein pod1 is critically important for kidney and lung organogenesis
    S E Quaggin
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada M5G 1X5
    Development 126:5771-83. 1999
    ..Defects specific to later specialized cell types where Pod1 is expressed, such as the podocytes, were also observed, suggesting that this transcription factor may play multiple roles in kidney morphogenesis...
  21. ncbi Pulmonary hypoplasia in mice lacking tumor necrosis factor-alpha converting enzyme indicates an indispensable role for cell surface protein shedding during embryonic lung branching morphogenesis
    J Zhao
    Center for Craniofacial Molecular Biology, University of Southern California, 2250 Alcazar St, CSA 103, Los Angeles, California, 90033, USA
    Dev Biol 232:204-18. 2001
    ....
  22. pmc Altered stability of pulmonary surfactant in SP-C-deficient mice
    S W Glasser
    Division of Pulmonary Biology, Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    Proc Natl Acad Sci U S A 98:6366-71. 2001
    ....
  23. ncbi Branching and differentiation defects in pulmonary epithelium with elevated Gata6 expression
    M Koutsourakis
    Department of Cell Biology and Genetics, Erasmus University Medical Centre Rotterdam, P O Box 1738, 3000 DR, The, Rotterdam, Netherlands
    Mech Dev 105:105-14. 2001
    ..Thus, elevated levels of GATA6 protein affect early lung development and in analogy to other GATA factors in other tissues, GATA6 also plays a crucial role in the terminal differentiation in this case of the distal pulmonary epithelium...
  24. ncbi Nuclear factor I-B (Nfib) deficient mice have severe lung hypoplasia
    Albert Gründer
    Institut fur Biologie III, Albert Ludwigs Universitat, Freiburg, Germany
    Mech Dev 112:69-77. 2002
    ..Our study demonstrates that Nfib is essential for normal lung development, and suggests that it could be involved in the pathogenesis of respiratory distress syndromes in humans...
  25. ncbi GATA6 regulates differentiation of distal lung epithelium
    Honghua Yang
    Department of Medicine, Molecular Cardiology Research Center, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Development 129:2233-46. 2002
    ..Together, these data implicate GATA6 as an important regulator of distal epithelial cell differentiation and proximal airway development in the mouse...
  26. ncbi Pneumonitis and emphysema in sp-C gene targeted mice
    Stephan W Glasser
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Ohio 45229 3039, USA
    J Biol Chem 278:14291-8. 2003
    ..Absence of SP-C caused a severe progressive pulmonary disorder with histologic features consistent with interstitial pneumonitis...
  27. ncbi TTF-1 phosphorylation is required for peripheral lung morphogenesis, perinatal survival, and tissue-specific gene expression
    Mario DeFelice
    Stazione Zoologica A Dohrn, Villa Comunale, 80121 Naples, Italy
    J Biol Chem 278:35574-83. 2003
    ..Direct and indirect transcriptional targets of TTF-1 were identified that are likely to play important roles in lung formation and function...
  28. ncbi Role for ETS domain transcription factors Pea3/Erm in mouse lung development
    Yuru Liu
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Dev Biol 261:10-24. 2003
    ..Our results provide the first functional evidence that Pea3 subfamily members play a role in epithelial-mesenchymal interactions during lung organogenesis...
  29. pmc Nuclear factor I/thyroid transcription factor 1 interactions modulate surfactant protein C transcription
    Cindy J Bachurski
    Division of Pulmonary Biology, Cincinnati Children s Research Foundation, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Mol Cell Biol 23:9014-24. 2003
    Surfactant protein C (SP-C; Sftpc) gene expression is restricted to pulmonary type II epithelial cells...
  30. ncbi Defective lung vascular development and fatal respiratory distress in endothelial NO synthase-deficient mice: a model of alveolar capillary dysplasia?
    Robin N N Han
    Terrence Donnelly Heart Center, Division of Cardiology, St Michael s Hospital and the Department of Medicine, University of Toronto, Toronto, Canada
    Circ Res 94:1115-23. 2004
    ..We conclude that eNOS plays a previously unrecognized role in lung development, which may have relevance for clinical syndromes of neonatal respiratory distress...
  31. pmc Hyperactive Wnt signaling changes the developmental potential of embryonic lung endoderm
    Tadashi Okubo
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    J Biol 3:11. 2004
    ..The full range of effects of this pathway, which includes the transcription factor Lef1, has not been explored, however...
  32. pmc Foxa2 is required for transition to air breathing at birth
    Huajing Wan
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center and University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Proc Natl Acad Sci U S A 101:14449-54. 2004
    ..Foxa2 regulates a complex pulmonary program of epithelial cell maturation required for transition to air breathing at birth...
  33. ncbi Compensatory roles of Foxa1 and Foxa2 during lung morphogenesis
    Huajing Wan
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, Ohio 45229 3039, USA
    J Biol Chem 280:13809-16. 2005
    ..Foxa family members regulate signaling and transcriptional programs required for morphogenesis and cell differentiation during formation of the lung...
  34. ncbi Nmyc plays an essential role during lung development as a dosage-sensitive regulator of progenitor cell proliferation and differentiation
    Tadashi Okubo
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Development 132:1363-74. 2005
    ..Overexpression of NmycEGFP in the epithelium under the control of surfactant protein C (Sftpc) regulatory elements expands the domain of S phase cells and upregulates numerous genes associated with growth and ..
  35. ncbi Wnt/beta-catenin signaling acts upstream of N-myc, BMP4, and FGF signaling to regulate proximal-distal patterning in the lung
    Weiguo Shu
    Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Dev Biol 283:226-39. 2005
    ..Thus, Wnt/beta-catenin signaling is a critical upstream regulator of proximal-distal patterning in the lung, in part, through regulation of N-myc, BMP4, and FGF signaling...
  36. ncbi Alterations in alveolar epithelium differentiation and vasculogenesis in lungs of LIF/IGF-I double deficient embryos
    Nuria Moreno-Barriuso
    Instituto de Biologia Molecular y Celular del Cancer, Consejo Superior de Investigaciones Cientificas Universidad de Salamanca, Salamanca, Spain
    Dev Dyn 235:2040-50. 2006
    ..The differentiation of type I cells barely occurred and capillaries remained in the abundant mesenchyme. These results indicate that LIF collaborates with IGF-I in lung alveolar epithelium and vascular maturation...
  37. pmc The Hsp90 cochaperone p23 is essential for perinatal survival
    Iwona Grad
    Departement de Biologie Cellulaire, Universite de Geneve, Sciences III, 1211 Geneve 4, Switzerland
    Mol Cell Biol 26:8976-83. 2006
    ..Thus, p23 contributes a nonredundant, temporally restricted, and tissue-specific function during mouse development...
  38. pmc Physical and functional interactions between homeodomain NKX2.1 and winged helix/forkhead FOXA1 in lung epithelial cells
    Parviz Minoo
    Department of Pediatrics, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA
    Mol Cell Biol 27:2155-65. 2007
    ..winged-helix/forkhead family of FOXA transcription factors to regulate two spatially and cell type-specific genes, SpC and Ccsp. The results show that NKX2.1 interacts physically and functionally with FOXA1...
  39. ncbi Foxp2 and Foxp1 cooperatively regulate lung and esophagus development
    Weiguo Shu
    Cardiovascular Institute, University of Pennsylvania, 956 BRB II III, 421 Curie Blvd, Philadelphia, PA 19104, USA
    Development 134:1991-2000. 2007
    ....
  40. pmc Fgf10 dosage is critical for the amplification of epithelial cell progenitors and for the formation of multiple mesenchymal lineages during lung development
    Suresh K Ramasamy
    Developmental Biology Program, Saban Research Institute of Childrens Hospital Los Angeles, Los Angeles, CA 90027, USA
    Dev Biol 307:237-47. 2007
    ..Thus, our results indicate that FGF10 plays a pivotal role in maintaining epithelial progenitor cell proliferation as well as coordinating alveolar smooth muscle cell formation and vascular development...
  41. ncbi NF-kB induces lung maturation during mouse lung morphogenesis
    Vedang A Londhe
    Department of Pediatrics, Division of Neonatology and Developmental Biology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095 1752, USA
    Dev Dyn 237:328-38. 2008
    ..These findings are consistent with a model whereby NF-kB may induce maturation of lung development through decreased apoptosis of epithelial cells...
  42. pmc Misexpression of MIA disrupts lung morphogenesis and causes neonatal death
    Sui Lin
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Dev Biol 316:441-55. 2008
    ..exogenous MIA caused significant reductions in the expression of the lung differentiation markers Sftpa, Sftpb, Sftpc, and Abca3. Bitransgenic mice expressing MIA under the control of the SFTPC promoter after E16...
  43. pmc Conditional stabilization of beta-catenin expands the pool of lung stem cells
    Susan D Reynolds
    Center for Lung Regeneration, Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Stem Cells 26:1337-46. 2008
    ..Our data demonstrate that the differentiation-modulating activities of stabilized beta-catenin account for expansion of tissue stem cells...
  44. pmc Misexpression of ELF5 disrupts lung branching and inhibits epithelial differentiation
    David E Metzger
    Division of Pulmonary Biology, Cincinnati Children s Hosptial Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Dev Biol 320:149-60. 2008
    ..inducible HA-tagged mouse Elf5 transgene was placed under the control of the lung epithelium-specific human SFTPC promoter...
  45. pmc Macrophage dysfunction and susceptibility to pulmonary Pseudomonas aeruginosa infection in surfactant protein C-deficient mice
    Stephan W Glasser
    Division of Pulmonary Biology, Department of Pediatrics, Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229 3039, USA
    J Immunol 181:621-8. 2008
    To determine the role of surfactant protein C (SP-C) in host defense, SP-C-deficient (Sftpc-/-) mice were infected with the pulmonary pathogen Pseudomonas aeruginosa by intratracheal injection...
  46. pmc Kruppel-like factor 5 is required for perinatal lung morphogenesis and function
    Huajing Wan
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center and the University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Development 135:2563-72. 2008
    ..KLF5 regulates genes controlling paracrine interactions during lung morphogenesis, as well as those regulating the maturation of the respiratory epithelium that is required for lung function after birth...
  47. doi Role for ephrinB2 in postnatal lung alveolar development and elastic matrix integrity
    George A Wilkinson
    Department of Molecular Neurobiology, Max Planck Institute of Neurobiology, Munich Martinsried, Germany
    Dev Dyn 237:2220-34. 2008
    ..Postnatal day 1 mutant lungs show extracellular matrix alterations without differences in proportions of major distal cell populations. We conclude that lung alveolar formation relies on endothelial ephrinB2 function...
  48. pmc Surfactant protein C-deficient mice are susceptible to respiratory syncytial virus infection
    Stephan W Glasser
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    Am J Physiol Lung Cell Mol Physiol 297:L64-72. 2009
    ..more severe interstitial thickening, air space consolidation, and goblet cell hyperplasia in SP-C-deficient (Sftpc(-/-)) mice compared with SP-C replete mice...
  49. pmc Nedd4-2-mediated ubiquitination facilitates processing of surfactant protein-C
    Juliana J Conkright
    Cincinnati Children s Hospital Medical Center, Division of Pulmonary Biology, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Am J Respir Cell Mol Biol 42:181-9. 2010
    ..Adenoviruses encoding mutant proproteins were infected into type II cells isolated from Sftpc(-/-) mice, and media analyzed for secreted SP-C 24 hours after infection...
  50. pmc Notch signaling controls the balance of ciliated and secretory cell fates in developing airways
    Po Nien Tsao
    Pulmonary Center, Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    Development 136:2297-307. 2009
    ..It might also be relevant to mediate the metaplastic changes in the respiratory epithelium that occur in pathological conditions, such as asthma and chronic obstructive pulmonary disease...
  51. pmc Deletion of Pten expands lung epithelial progenitor pools and confers resistance to airway injury
    Caterina Tiozzo
    Department of Pediatrics, Division of Neonatology, Women s and Children s Hospital, USC Keck School of Medicine
    Am J Respir Crit Care Med 180:701-12. 2009
    ..In mouse, Pten expression is ubiquitous and begins as early as 7 days of gestation. Pten(-/-) mouse embryos die early during gestation indicating a critical role for Pten in embryonic development...
  52. pmc Wnt2/2b and beta-catenin signaling are necessary and sufficient to specify lung progenitors in the foregut
    Ashley M Goss
    Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Dev Cell 17:290-8. 2009
    ..Together, these data reveal that canonical Wnt2/2b signaling is required for the specification of lung endoderm progenitors in the developing foregut...
  53. pmc Mig-6 is required for appropriate lung development and to ensure normal adult lung homeostasis
    Nili Jin
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Development 136:3347-56. 2009
    ..These results demonstrate that Mig-6 is required for prenatal and perinatal lung development, in part through the regulation of EGF signaling, as well as for maintaining proper pulmonary vascularization...
  54. pmc Loss of Erk3 function in mice leads to intrauterine growth restriction, pulmonary immaturity, and neonatal lethality
    Sonia Klinger
    Institut de Recherche en Immunologie et Cancérologie and Departments of Pharmacology and Molecular Biology, Universite de Montreal, Montreal, Quebec, Canada
    Proc Natl Acad Sci U S A 106:16710-5. 2009
    ..Our findings reveal a critical role for Erk3 in the establishment of fetal growth potential and pulmonary function in the mouse...
  55. pmc The PCP genes Celsr1 and Vangl2 are required for normal lung branching morphogenesis
    Laura L Yates
    Medical Research Council, Harwell, Oxfordshire OX11 0RD, UK
    Hum Mol Genet 19:2251-67. 2010
    ....
  56. pmc LPCAT1 regulates surfactant phospholipid synthesis and is required for transitioning to air breathing in mice
    James P Bridges
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio45229, USA
    J Clin Invest 120:1736-48. 2010
    ..Collectively, these data demonstrate that full LPCAT1 activity is required to achieve the levels of SatPC essential for the transition to air breathing...
  57. pmc CARM1 is required for proper control of proliferation and differentiation of pulmonary epithelial cells
    Karen B O'Brien
    Harvard Stem Cell Institute and Center for Life Sciences, Harvard Medical School, Boston, MA 02115, USA
    Development 137:2147-56. 2010
    ..These results demonstrate for the first time that CARM1 inhibits pulmonary cell proliferation and is required for proper differentiation of alveolar cells...
  58. pmc Signaling through BMP receptors promotes respiratory identity in the foregut via repression of Sox2
    Eric T Domyan
    Laboratory of Genetics, University of Wisconsin Madison, Madison, WI 53706, USA
    Development 138:971-81. 2011
    ....
  59. pmc Eya1 controls cell polarity, spindle orientation, cell fate and Notch signaling in distal embryonic lung epithelium
    Ahmed H K El-Hashash
    Developmental Biology and Regenerative Medicine Program, Saban Research Institute, Childrens Hospital Los Angeles, Keck School of Medicine of University of Southern California, 4661 Sunset Boulevard, Los Angeles, CA 90027, USA
    Development 138:1395-407. 2011
    ..Indeed, genetic activation of Notch partially rescues Eya1(-/-) lung epithelial defects. These findings uncover novel functions for Eya1 as a crucial regulator of the complex behavior of distal embryonic lung epithelium...
  60. pmc cAMP response element binding protein is required for differentiation of respiratory epithelium during murine development
    A Daniel Bird
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia
    PLoS ONE 6:e17843. 2011
    ..Together, these results demonstrate a crucial role for Creb1 activity for the development and differentiation of the conducting and distal lung epithelium...
  61. pmc Follistatin-like 1 (Fstl1) is a bone morphogenetic protein (BMP) 4 signaling antagonist in controlling mouse lung development
    Yan Geng
    Model Animal Research Center, Nanjing University, Nanjing 210061, China
    Proc Natl Acad Sci U S A 108:7058-63. 2011
    ..Therefore, we provide in vivo and in vitro evidence to demonstrate that Fstl1 modulates lung development and alveolar maturation, in part, through BMP4 signaling...
  62. pmc Integrin α6β4 identifies an adult distal lung epithelial population with regenerative potential in mice
    Harold A Chapman
    Department of Medicine, Cardiovascular Research Institute, and Lung Biology Center, UCSF, San Francisco, California 94143, USA
    J Clin Invest 121:2855-62. 2011
    ..alveolar epithelial cells (AECs) expressing the laminin receptor α6β4, but little or no pro-surfactant C (pro-SPC), is endowed with regenerative potential...
  63. pmc The BMP antagonist follistatin-like 1 is required for skeletal and lung organogenesis
    Marc Sylva
    Heart Failure Research Center, Academic Medical Center, Amsterdam, The Netherlands
    PLoS ONE 6:e22616. 2011
    ..Taken together, these observations show that Fstl1 is a crucial regulator in BMP signalling during mouse development...
  64. pmc Evidence for type II cells as cells of origin of K-Ras-induced distal lung adenocarcinoma
    Xia Xu
    Department of Surgery, Duke University, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 109:4910-5. 2012
    ..we use two "knock-in" Cre-estrogen receptor alleles to inducibly express K-RasG12D in CC10(+) epithelial cells and Sftpc(+) type II alveolar cells of the adult mouse lung...
  65. pmc Multiple roles and interactions of Tbx4 and Tbx5 in development of the respiratory system
    Ripla Arora
    Department of Genetics and Development, Columbia University Medical Center, New York, New York, United States of America
    PLoS Genet 8:e1002866. 2012
    ..Finally, we show that Tbx4 and Tbx5 interact with Fgf10 during the process of lung growth and branching but not during tracheal/bronchial cartilage development...
  66. pmc Deletion of mesenchymal glucocorticoid receptor attenuates embryonic lung development and abdominal wall closure
    Aiqing Li
    Bone Research Program, ANZAC Research Institute, University of Sydney, Sydney, Australia
    PLoS ONE 8:e63578. 2013
    ..In addition, altered glucocorticoid signaling in the mesenchyme attenuates normal lung epithelial differentiation...
  67. pmc Localized Fgf10 expression is not required for lung branching morphogenesis but prevents differentiation of epithelial progenitors
    Thomas Volckaert
    Department of Pediatrics, Division of Cell Biology, National Jewish Health, Denver, CO 80206, USA
    Development 140:3731-42. 2013
    ..Interestingly, our data presented here show that once epithelial cells are committed to the Sox2-positive airway epithelial cell fate, Fgf10 prevents ciliated cell differentiation and promotes basal cell differentiation. ..
  68. ncbi Thyroid transcription factor-1, hepatocyte nuclear factor-3beta, surfactant protein B, C, and Clara cell secretory protein in developing mouse lung
    L Zhou
    Children s Hospital Medical Center, Division of Pulmonary Biology, Cincinnati, Ohio 45229 3039, USA
    J Histochem Cytochem 44:1183-93. 1996
    ..The early expression of TTF-1 and HNF-3beta, preceding and overlapping that of pro-SP-B, mature SP-B, pro-SP-C, and CCSP, supports a regulatory role for TTF-1 and HNF-3beta in lung-specific gene expression...
  69. ncbi Thyroid transcription factor (TTF) -1 regulates the expression of midkine (MK) during lung morphogenesis
    Paul R Reynolds
    Cincinnati Children s Hospital Medical Center, Division of Pulmonary Biology, Cincinnati, Ohio 45229 3039, USA
    Dev Dyn 227:227-37. 2003
    ..5, colocalizing with the Clara cell secretory protein (CCSP) marker in conducting airways and with pro-SPC, a marker specific for alveolar type II pneumocytes...
  70. ncbi Distinctive functions of membrane type 1 matrix-metalloprotease (MT1-MMP or MMP-14) in lung and submandibular gland development are independent of its role in pro-MMP-2 activation
    Samantha A Oblander
    Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Dev Biol 277:255-69. 2005
    ....
  71. ncbi Elf5 is an epithelium-specific, fibroblast growth factor-sensitive transcription factor in the embryonic lung
    David E Metzger
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    Dev Dyn 236:1175-92. 2007
    ..5 lungs. These results demonstrate that Elf5 is an FGF-sensitive transcription factor in the lung with a dynamic pattern of expression and that FGF regulation of Elf5 by means of FGFR2b occurs through the PI3-Kinase/Akt pathway...
  72. ncbi Epithelial-vascular cross talk mediated by VEGF-A and HGF signaling directs primary septae formation during distal lung morphogenesis
    Hiroaki Yamamoto
    Department of Medicine and Lung Biology Center, University of California, San Francisco, CA 94143, USA
    Dev Biol 308:44-53. 2007
    ....
  73. pmc A Gata6-Wnt pathway required for epithelial stem cell development and airway regeneration
    Yuzhen Zhang
    Department of Medicine, University of Pennsylvania, 956 BRB II III, 421 Curie Boulevard, Philadelphia, Pennsylvania 19104, USA
    Nat Genet 40:862-70. 2008
    ..Together, these data demonstrate that Gata6-regulated Wnt signaling controls the balance between progenitor expansion and epithelial differentiation required for both lung development and regeneration...
  74. pmc Lymphatic function is required prenatally for lung inflation at birth
    Zoltan Jakus
    Department of Medicine, 2 Cardiovascular Institute, and 3 Department of Dermatology, University of Pennsylvania, Philadelphia, PA 19104
    J Exp Med 211:815-26. 2014
    ..They explain respiratory failure in infants with congenital pulmonary lymphangiectasia, and suggest that inadequate late gestation lymphatic function may also contribute to respiratory failure in premature infants. ..
  75. ncbi HNF-3/forkhead homologue-4 influences lung morphogenesis and respiratory epithelial cell differentiation in vivo
    J W Tichelaar
    Division of Pulmonary Biology, Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Ohio, 45229 3039, USA
    Dev Biol 213:405-17. 1999
    ..Ectopic expression of HFH-4 in developing mouse lung altered epithelial cell differentiation and morphology, restricting the expression of markers typical of nonciliated cells of the distal lung parenchyma...
  76. pmc Surfactant protein-C chromatin-bound green fluorescence protein reporter mice reveal heterogeneity of surfactant protein C-expressing lung cells
    Joo Hyeon Lee
    Stem Cell Program, Boston Children s Hospital, Boston, MA, USA
    Am J Respir Cell Mol Biol 48:288-98. 2013
    ..chromatin-bound green fluorescence protein reporter (H2B-GFP) was driven from the murine surfactant protein-C (SPC) promoter to generate SPC H2B-GFP transgenic mice...
  77. ncbi TGF-beta3-null mutation does not abrogate fetal lung maturation in vivo by glucocorticoids
    W Shi
    Developmental Biology Program, Childrens Hospital Los Angeles and University of Southern California School of Medicine, Los Angeles 90027, California
    Am J Physiol 277:L1205-13. 1999
    ..This finding provides direct evidence that glucocorticoid signaling in the lung can use alternative pathways and can exert its effect without the presence of TGF-beta3...
  78. ncbi Overexpression of surfactant protein-C mature peptide causes neonatal lethality in transgenic mice
    Juliana Johnson Conkright
    Division of Pulmonary Biology, Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    Am J Respir Cell Mol Biol 26:85-90. 2002
    ..These results suggest that elevated expression of SP-C(24-57)HA in type II cells resulted in aggregation of SP-C in the early secretory pathway, leading to cytotoxicity and, ultimately, altered lung development...
  79. ncbi Deficiency of SP-B reveals protective role of SP-C during oxygen lung injury
    Machiko Ikegami
    Children s Hospital Medical Center, Division of Pulmonary Biology, Cincinnati, Ohio 45229 3039, USA
    J Appl Physiol (1985) 92:519-26. 2002
    ..Genetically decreased levels of SP-B combined with superimposed O(2)-induced injury reveals the distinct contribution of SP-C to pulmonary function in vivo...
  80. ncbi Specific ablation of the nidogen-binding site in the laminin gamma1 chain interferes with kidney and lung development
    Michael Willem
    Max Planck Institute for Biochemistry, Department of Protein Chemistry, 82152 Martinsried, Germany
    Development 129:2711-22. 2002
    ..These data demonstrate that an interaction between two basement membrane proteins is required for early kidney morphogenesis in vivo...
  81. pmc Sim2 mutants have developmental defects not overlapping with those of Sim1 mutants
    Eleni Goshu
    Department of Embryology, Carnegie Institution of Washington, Baltimore, Maryland 21210, USA
    Mol Cell Biol 22:4147-57. 2002
    ..The temporal and spatial expression patterns of Sim2 in these skeletal elements suggest that Sim2 regulates their growth and/or integrity...
  82. ncbi Mesenchymal expression of vascular endothelial growth factors D and A defines vascular patterning in developing lung
    James M Greenberg
    Division of Pulmonary Biology, Children s Hospital Research Foundation, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    Dev Dyn 224:144-53. 2002
    ..Our results demonstrate unique temporal and spatial expression of VEGF-D and specific VEGF-A isoforms during lung development and suggest these related factors have distinct functions in vascular and lymphatic patterning of the lung...
  83. ncbi Expression of a human surfactant protein C mutation associated with interstitial lung disease disrupts lung development in transgenic mice
    James P Bridges
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    J Biol Chem 278:52739-46. 2003
    ..Mutations in the gene encoding SP-C (SFTPC) have recently been linked to chronic lung disease in children and adults...
  84. pmc Late gestational lung hypoplasia in a mouse model of the Smith-Lemli-Opitz syndrome
    Hongwei Yu
    Division of Endocrinology, Diabetes and Medical Genetics, Medical University of South Carolina, STR 541, 114 Doughty Street, Charleston, SC 29403, USA
    BMC Dev Biol 4:1. 2004
    ..Although they have a number of biochemical and structural abnormalities, one cause of death is from apparent respiratory failure due to developmental pulmonary abnormalities...
  85. ncbi Protein phosphatase 1alpha is required for murine lung growth and morphogenesis
    Kadija Kathy Hormi-Carver
    Division of Hematology Oncology, Department of Pediatrics, Childrens Hospital Los Angeles, University of Southern California School of Medicine, Los Angeles, California, USA
    Dev Dyn 229:791-801. 2004
    ..These data suggest that PP1alpha is required for branching morphogenesis and differentiation...
  86. ncbi Normal lung development in RAIG1-deficient mice despite unique lung epithelium-specific expression
    Jingsong Xu
    Harvard Medical School, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
    Am J Respir Cell Mol Biol 32:381-7. 2005
    ..Analysis of other family members demonstrated some overlapping embryonic expression of RAIG3 mRNA that could have led to functional redundancy in the single RAIG1 null mutant mouse...
  87. ncbi PI3K-AKT pathway mediates growth and survival signals during development of fetal mouse lung
    J Wang
    Department of Pathology, Yokohama City University Graduate School of Medicine, Yokohama, Japan
    Tissue Cell 37:25-35. 2005
    ..At the same time, the effect of LY294002, wortmannin, PD98059 on expression of surfactant apoprotein C (SPC) were also studied. The LY294002 and wortmannin treatments showed decreased expression of SPC...
  88. pmc Dysregulation of TGF-beta1 receptor activation leads to abnormal lung development and emphysema-like phenotype in core fucose-deficient mice
    Xiangchun Wang
    Department of Biochemistry, Osaka University Graduate School of Medicine, Osaka 565 0871, Japan
    Proc Natl Acad Sci U S A 102:15791-6. 2005
    ..We propose that the lack of core fucosylation of TGF-beta1 receptors is crucial for a developmental and progressive/destructive emphysema, suggesting that perturbation of this function could underlie certain cases of human emphysema...
  89. ncbi Distinct roles for retinoic acid receptors alpha and beta in early lung morphogenesis
    Tushar J Desai
    Pulmonary Center, Boston University School of Medicine, 80 East Concord Street R 304, Boston, MA 02118, USA
    Dev Biol 291:12-24. 2006
    ..Our data support the idea that balanced activation of RAR alpha and beta is critical for proper lung bud initiation and endodermal differentiation...
  90. pmc Identification and characterization of a lysophosphatidylcholine acyltransferase in alveolar type II cells
    Xueni Chen
    Department of Medicine, National Jewish Medical and Research Center, Denver, CO 80206, USA
    Proc Natl Acad Sci U S A 103:11724-9. 2006
    ..We hypothesize that LPCAT plays a critical role in regulating surfactant phospholipid biosynthesis and suggest that understanding the regulation of LPCAT will offer important insight into surfactant phospholipid biosynthesis...
  91. pmc E2f4 is required for normal development of the airway epithelium
    Paul S Danielian
    Center for Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Dev Biol 305:564-76. 2007
    ..Importantly, the combination of no ciliated cells and excess mucous cells can account for the chronic rhinitis and increased susceptibility to opportunistic infections that causes the postnatal lethality of E2f4 mutant mice...
  92. pmc Transgenic over-expression of the microRNA miR-17-92 cluster promotes proliferation and inhibits differentiation of lung epithelial progenitor cells
    Yun Lu
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Dev Biol 310:442-53. 2007
    ..We used the mouse surfactant protein C (Sftpc) promoter to over-express the cluster in embryonic lung epithelium...
  93. ncbi A role for macrophage migration inhibitory factor in the neonatal respiratory distress syndrome
    Katharine A Kevill
    Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520, USA
    J Immunol 180:601-8. 2008
    ..03). This study demonstrates for the first time a role for MIF in lung maturation, and supports a protective role for MIF in newborn lung disease...
  94. doi Systemic inactivation of Hs6st1 in mice is associated with late postnatal mortality without major defects in organogenesis
    Konstantin I Izvolsky
    Pulmonary Center, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Genesis 46:8-18. 2008
    ..Our results suggest a potentially critical role for HS 6-O sulfation by Hs6st1 in postnatal processes...
  95. pmc TGF-beta receptor II in epithelia versus mesenchyme plays distinct roles in the developing lung
    H Chen
    Developmental Biology Program, Dept of Surgery, Childrens Hospital Los Angeles, 4650 Sunset Blvd, MS 35, Los Angeles, CA 90027, USA
    Eur Respir J 32:285-95. 2008
    ....
  96. pmc Cited2 is required for fetal lung maturation
    Bing Xu
    Department of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    Dev Biol 317:95-105. 2008
    ..We propose that the Cited2-Tcfap2c complex controls lung maturation by regulating Cebpa expression. Understanding the function of this complex may provide novel therapeutic strategies for patients with respiratory distress syndromes...
  97. pmc A mouse model for Costello syndrome reveals an Ang II-mediated hypertensive condition
    Alberto J Schuhmacher
    Molecular Oncology Programme, Centro Nacional de Investigaciones Oncologicas, Madrid, Spain
    J Clin Invest 118:2169-79. 2008
    ..In addition, it partially alleviated the observed cardiomyopathies. These mice should help in elucidating the etiology of CS symptoms, identifying additional defects, and evaluating potential therapeutic strategies...
  98. pmc Bmp2 and Bmp4 genetically interact to support multiple aspects of mouse development including functional heart development
    Takashi Uchimura
    Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA
    Genesis 47:374-84. 2009
    ..These results suggest that the dosage of both BMP2 and 4 is critical for functional heart formation during embryogenesis and after birth...
  99. pmc Truncation of the catalytic domain of the cylindromatosis tumor suppressor impairs lung maturation
    Eirini Trompouki
    Institute of Immunology, Biomedical Sciences Research Center Al Fleming, 34 Al Fleming Str, Vari 16672, Greece
    Neoplasia 11:469-76. 2009
    ..and endothelial structures. Our study identifies an important role of CYLD in lung maturation, which may underlie the development of many cases of lung cancer...
  100. pmc The Id2+ distal tip lung epithelium contains individual multipotent embryonic progenitor cells
    Emma L Rawlins
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Development 136:3741-5. 2009
    ..Taken together, this evidence supports a model in which the distal tip of the developing lung contains a multipotent epithelial population, the fate of which changes during development...
  101. pmc Altered lung morphogenesis, epithelial cell differentiation and mechanics in mice deficient in the Wnt/β-catenin antagonist Chibby
    Damon Love
    Department of Pharmacological Sciences, SUNY at Stony Brook, Stony Brook, New York, United States of America
    PLoS ONE 5:e13600. 2010
    ..Moreover, we demonstrate that Cby is a direct downstream target for the master ciliogenesis transcription factor Foxj1. Collectively, our results demonstrate that Cby facilitates proper postnatal lung development and function...

Research Grants10

  1. Excess TGF beta in neonatal lung injury and repair
    David Warburton; Fiscal Year: 2004
    ..abstract_text> ..
  2. Lung epithelial and vascular morphogenesis
    David Warburton; Fiscal Year: 2006
    ..abstract_text> ..
  3. AUTOCRINE/PARACRINE GROWTH FACTORS & LUNG MORPHOGENESIS
    David Warburton; Fiscal Year: 2009
    ..Aim 4: To determine the role of tyrosine phosphorylation in protein-protein interaction and supra-molecular assembly of mSPRY2 with SHP2 and FRS2. Aim 5: To determine the functional importance of Shp2 in lung morphogenesis in vivo. ..
  4. DEVELOPMENTAL TYPE II PNEUMOCYTE PROTEIN PHOSPHORYLATION
    David Warburton; Fiscal Year: 2010
    ..Inosine may function as a low molecular weight therapeutic to ameliorate lung injury, protect lung progenitor cells and hence to promote recovery of the alveolar epithelium from acute injury in both adult and neonate. ..
  5. CYSTEINE PROTEASES IN MHC CLASS II ANTIGEN PRESENTATION
    Harold Chapman; Fiscal Year: 2007
    ..abstract_text> ..
  6. PLASMIN, FIBRIN, AND METALLOPROTEINASES IN LUNG FIBROSIS
    Thomas Sisson; Fiscal Year: 2004
    ..The opportunities provided by the training program will provide the foundation for career advancement and hopefully lead to new therapies for fibrotic lung diseases. ..
  7. BR22, A Novel Protein Interacting with TTF-1
    Yih Sheng Yang; Fiscal Year: 2005
    ..Two-color or triple-color staining of endogenous proteins in H441 cells or the lung sections will be performed to detect their expression in SP-B producing cells. ..
  8. Role of NFI in type II Cell Function
    CINDY BACHURSKI; Fiscal Year: 2006
    ..These studies may provide a basis for the rational design of new treatment strategies for neonatal pulmonary disease and bronchopulmonary dysplasia. [unreadable] [unreadable]..
  9. Interactive Mediators of Injury & Development
    Parviz Minoo; Fiscal Year: 2008
    ..1. ..
  10. Fetal Lung Development:Role of Wnt5a Signaling
    Changgong Li; Fiscal Year: 2008
    ..Specific Aim 1. To further investigate the role Wnt5a by generating & characterizing SpC: Wnt5a transgenic mice. Specific Aim 2...