Sfrp1

Summary

Gene Symbol: Sfrp1
Description: secreted frizzled-related protein 1
Alias: 2210415K03Rik, AW011917, AW107218, AW742929, sFRP-1, secreted frizzled-related protein 1, secreted frizzled-related sequence protein 1
Species: mouse

Top Publications

  1. doi Early B cell factor 2 regulates hematopoietic stem cell homeostasis in a cell-nonautonomous manner
    Matthias Kieslinger
    Department of Cellular and Molecular Immunology, Max Planck Institute of Immunobiology, 79108 Freiburg, Germany
    Cell Stem Cell 7:496-507. 2010
  2. doi Tumour supressor secreted frizzled related protein 1 regulates p53-mediated apoptosis
    Kelly J Gauger
    Pioneer Valley Life Sciences Institute, Baystate Medical Center, Springfield, Massachusetts, 01199, USA Department of Biology, University of Massachusetts, Amherst, Massachusetts, 01003, USA
    Cell Biol Int 38:124-30. 2014
  3. doi Satb2 is a postmitotic determinant for upper-layer neuron specification in the neocortex
    Olga Britanova
    Max Planck Institute for Experimental Medicine, Hermann Rein Strasse 3, 37075 Gottingen, Germany
    Neuron 57:378-92. 2008
  4. ncbi Loss- and gain-of-function analyses reveal targets of Pax6 in the developing mouse telencephalon
    Pontus C Holm
    Institute for Stem Cell Research, National Research Center for Environment and Health, Ingolstadter Landstrasse 1, D 85764 Neuherberg Munich, Germany
    Mol Cell Neurosci 34:99-119. 2007
  5. doi Sfrp1, Sfrp2, and Sfrp5 regulate the Wnt/beta-catenin and the planar cell polarity pathways during early trunk formation in mouse
    Wataru Satoh
    Vertebrate Body Plan, Center for Developmental Biology, RIKEN Kobe, Minatojima Minami, Chuou ku, Kobe, Japan
    Genesis 46:92-103. 2008
  6. pmc Expression of secreted frizzled related protein 1, a Wnt antagonist, in brain, kidney, and skeleton is dispensable for normal embryonic development
    Brune Trevant
    Department of Cell Biology and Cancer Center, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Cell Physiol 217:113-26. 2008
  7. doi SFRPs act as negative modulators of ADAM10 to regulate retinal neurogenesis
    Pilar Esteve
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas Universidad Autonoma de Madrid, Madrid, Spain
    Nat Neurosci 14:562-9. 2011
  8. doi Secreted frizzled-related protein-1 improves postinfarction scar formation through a modulation of inflammatory response
    Laurent Barandon
    Universite de Bordeaux, Adaptation Cardiovasculaire à l ischémie, U1034, Pessac, France
    Arterioscler Thromb Vasc Biol 31:e80-7. 2011
  9. ncbi Sfrp1 and Sfrp2 regulate anteroposterior axis elongation and somite segmentation during mouse embryogenesis
    Wataru Satoh
    Vertebrate Body Plan, Center for Developmental Biology, RIKEN Kobe, Chuou ku, Kobe 650 0047, Japan
    Development 133:989-99. 2006
  10. pmc Loss of SFRP1 promotes ductal branching in the murine mammary gland
    Kelly J Gauger
    Pioneer Valley Life Sciences Institute, Baystate Medical Center, Springfield, MA 01199, USA
    BMC Dev Biol 12:25. 2012

Scientific Experts

  • Makoto Matsuyama
  • Sallie S Schneider
  • Eveline Boudin
  • Kelly J Gauger
  • Stacy L Donovan
  • Pontus C Holm
  • Hideaki Nakajima
  • Patrick Pla
  • Peter V N Bodine
  • Nina Solberg
  • Yutaka Matsuda
  • Gen Yamada
  • Matthias Kieslinger
  • Pilar Esteve
  • Steve E Jones
  • Georgina Caruana
  • Kamana Misra
  • Akihiko Shimono
  • Tripti Gaur
  • Wataru Satoh
  • Pascale Dufourcq
  • Laurent Barandon
  • Jeffrey S Rubin
  • Takayuki Shiomi
  • Shinichi Aizawa
  • Lionel Leroux
  • Catherine Moreau
  • Thierry Couffinhal
  • Margaret S Joesting
  • Cecile Duplaa
  • C H Li
  • Jerome Ezan
  • Isabelle Miletich
  • Paul T Sharpe
  • Paul C Marker
  • Sadiq Hussain
  • Barry S Komm
  • Gary S Stein
  • Jane B Lian
  • Brune Trevant
  • Stephanie Bonney
  • Byeong Moo Kim
  • Lea Chia Ling Hsu
  • Severine Marcos
  • Kelly J Gregory
  • Africa Sandonìs
  • Paola Bovolenta
  • Yuki Sugiyama
  • Randy S Levinson
  • Corey J Cain
  • Kimberly P Keil
  • Partha Mukhopadhyay
  • Mahua Mukhopadhyay
  • Julianna Kele
  • Ben Van Handel
  • Piotr Sklepkiewicz
  • Alvaro Sebastián-Serrano
  • Alisha R Yallowitz
  • Shinichi Miyagawa
  • Nisha Patel
  • Jingyuan Li
  • Janghee Woo
  • Xianting Li
  • Wei Liu
  • Robert Foronjy
  • Ondrej Machon
  • Jean Marie Daniel Lamazière
  • Jie Huang
  • Nick Warr
  • Colin Pritchard
  • Jonas Renström
  • Krista K Bluske
  • Dritan Agalliu
  • Ji Hye Paik
  • Takafumi Yokota
  • Olga Britanova
  • Ramesh A Shivdasani
  • Simon Descamps
  • Anna Svensson
  • Masaya Ikegawa
  • Samara L Lewis
  • Cécile Allières
  • Victor Tarabykin
  • Victoria H Cowling
  • Chiharu Kimura-Yoshida
  • Amaya Miquelajauregui
  • Danuta Wawrzak
  • Keisuke Kaji
  • Kenryo Furushima
  • Andy Greenfield

Detail Information

Publications93

  1. doi Early B cell factor 2 regulates hematopoietic stem cell homeostasis in a cell-nonautonomous manner
    Matthias Kieslinger
    Department of Cellular and Molecular Immunology, Max Planck Institute of Immunobiology, 79108 Freiburg, Germany
    Cell Stem Cell 7:496-507. 2010
    ..Thus, Ebf2 acts as a transcriptional determinant of an osteoblastic niche that regulates the maintenance of hematopoietic progenitors, in part by modulating Wnt signaling...
  2. doi Tumour supressor secreted frizzled related protein 1 regulates p53-mediated apoptosis
    Kelly J Gauger
    Pioneer Valley Life Sciences Institute, Baystate Medical Center, Springfield, Massachusetts, 01199, USA Department of Biology, University of Massachusetts, Amherst, Massachusetts, 01003, USA
    Cell Biol Int 38:124-30. 2014
    ..b>SFRP1 expression is lost in a multitude of cancers, including breast cancer, and SFRP1 down regulation reduces apoptosis ..
  3. doi Satb2 is a postmitotic determinant for upper-layer neuron specification in the neocortex
    Olga Britanova
    Max Planck Institute for Experimental Medicine, Hermann Rein Strasse 3, 37075 Gottingen, Germany
    Neuron 57:378-92. 2008
    ..Satb2 therefore is required for the initiation of the UL1-specific genetic program and for the inactivation of DL- and UL2-specific genes...
  4. ncbi Loss- and gain-of-function analyses reveal targets of Pax6 in the developing mouse telencephalon
    Pontus C Holm
    Institute for Stem Cell Research, National Research Center for Environment and Health, Ingolstadter Landstrasse 1, D 85764 Neuherberg Munich, Germany
    Mol Cell Neurosci 34:99-119. 2007
    ..Most intriguingly, this analysis revealed time- and region-specific differences in Pax6-mediated transcription, explaining the specific function of Pax6 at early and later stages of neurogenesis...
  5. doi Sfrp1, Sfrp2, and Sfrp5 regulate the Wnt/beta-catenin and the planar cell polarity pathways during early trunk formation in mouse
    Wataru Satoh
    Vertebrate Body Plan, Center for Developmental Biology, RIKEN Kobe, Minatojima Minami, Chuou ku, Kobe, Japan
    Genesis 46:92-103. 2008
    Sfrp is a secreted Wnt antagonist that directly interacts with Wnt ligand. We show here that inactivation of Sfrp1, Sfrp2, and Sfrp5 leads to fused somites formation in early-somite mouse embryos, simultaneously resulting in defective ..
  6. pmc Expression of secreted frizzled related protein 1, a Wnt antagonist, in brain, kidney, and skeleton is dispensable for normal embryonic development
    Brune Trevant
    Department of Cell Biology and Cancer Center, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Cell Physiol 217:113-26. 2008
    Secreted frizzled related protein-1 (sFRP1), an antagonist of Wnt signaling, regulates cell proliferation, differentiation and apoptosis and negatively regulates bone formation...
  7. doi SFRPs act as negative modulators of ADAM10 to regulate retinal neurogenesis
    Pilar Esteve
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas Universidad Autonoma de Madrid, Madrid, Spain
    Nat Neurosci 14:562-9. 2011
    ..We found that genetic inactivation of Sfrp1 and Sfrp2, two postulated Wnt antagonists, perturbs retinal neurogenesis...
  8. doi Secreted frizzled-related protein-1 improves postinfarction scar formation through a modulation of inflammatory response
    Laurent Barandon
    Universite de Bordeaux, Adaptation Cardiovasculaire à l ischémie, U1034, Pessac, France
    Arterioscler Thromb Vasc Biol 31:e80-7. 2011
    ..We aimed to further elucidate the role of sFRP-1 in the postischemic inflammatory process...
  9. ncbi Sfrp1 and Sfrp2 regulate anteroposterior axis elongation and somite segmentation during mouse embryogenesis
    Wataru Satoh
    Vertebrate Body Plan, Center for Developmental Biology, RIKEN Kobe, Chuou ku, Kobe 650 0047, Japan
    Development 133:989-99. 2006
    ..Here, we show that Sfrp1 and Sfrp2 are required for anteroposterior (AP) axis elongation and somitogenesis in the thoracic region during ..
  10. pmc Loss of SFRP1 promotes ductal branching in the murine mammary gland
    Kelly J Gauger
    Pioneer Valley Life Sciences Institute, Baystate Medical Center, Springfield, MA 01199, USA
    BMC Dev Biol 12:25. 2012
    ..Secreted frizzled-related proteins (SFRPs) are a family of proteins that block the Wnt signaling pathway and loss of SFRP1 expression is found in breast cancer along with a multitude of other human cancers...
  11. ncbi The Wnt antagonist secreted frizzled-related protein-1 controls osteoblast and osteocyte apoptosis
    Peter V N Bodine
    Women s Health Research Institute, Wyeth Research, Collegeville, Pennsylvania 19426, USA
    J Cell Biochem 96:1212-30. 2005
    ..Likewise, over-expression of sFRP-1 in HOBs accelerated the rate of cell death threefold. These results establish sFRP-1 as an important negative regulator of human osteoblast and osteocyte survival...
  12. ncbi Secreted frizzled-related protein-1 inhibits RANKL-dependent osteoclast formation
    Karl D Häusler
    Bone, Joint, and Cancer Unit, St Vincent s Institute of Medical Research, Fitzroy, Victoria, Australia
    J Bone Miner Res 19:1873-81. 2004
    ..In studying the mechanism of action for sFRP-1, we found that sFRP-1 could bind recombinant RANKL. These results suggest potential cross-talk between Wnt and RANKL pathways...
  13. ncbi FrzA/sFRP-1, a secreted antagonist of the Wnt-Frizzled pathway, controls vascular cell proliferation in vitro and in vivo
    Jerome Ezan
    INSERM U441, Avenue du Haut Leveque, 33 600 Pessac, France, and Université Victor Segalen Bordeaux 2, rue Leo Saignat, 33 000 Bordeaux, France
    Cardiovasc Res 63:731-8. 2004
    ..In this study, we aimed to examine the mechanisms by which FrzA exerts its antiproliferative effect on vascular cells in vitro and its potential effect in vivo...
  14. ncbi The Wnt antagonist secreted frizzled-related protein-1 is a negative regulator of trabecular bone formation in adult mice
    Peter V N Bodine
    Women s Health Research Institute, Wyeth Research, 500 Arcola Road, Collegeville, Pennsylvania 19426, USA
    Mol Endocrinol 18:1222-37. 2004
    ..Our findings demonstrate that deletion of sFRP-1 preferentially activates Wnt signaling in osteoblasts, leading to enhanced trabecular bone formation in adults...
  15. pmc Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action
    P W Finch
    Derald H Ruttenberg Cancer Center, Mount Sinai Medical Center, New York, NY 10029 6574, USA
    Proc Natl Acad Sci U S A 94:6770-5. 1997
    ..These results indicate that FRP may function as an inhibitor of Wnt action during development and in the adult...
  16. ncbi Developmental expression patterns of mouse sFRP genes encoding members of the secreted frizzled related protein family
    C Leimeister
    Department of Physiological Chemistry I, Theodor Boveri Institute Biocenter, University of Wuerzburg, Am Hubland, D 97074, Wuerzburg, Germany
    Mech Dev 75:29-42. 1998
    ..In a comparative analysis transcripts of the related sFRP1 and sFRP4 genes were frequently found in the same tissues as sFRP2 with their expression domains overlapping in ..
  17. pmc Mice deficient in Sfrp1 exhibit increased adiposity, dysregulated glucose metabolism, and enhanced macrophage infiltration
    Kelly J Gauger
    Pioneer Valley Life Sciences Institute, Baystate Medical Center, Springfield, Massachusetts, United States of America Biology Department, University of Massachusetts, Amherst, Massachusetts, United States of America
    PLoS ONE 8:e78320. 2013
    ..The expression of a Wnt antagonist, secreted frizzled related protein 1 (SFRP1), is increased in response to initial weight gain, then levels are reduced under conditions ..
  18. ncbi Regulation of Wnt signaling during adipogenesis
    Christina N Bennett
    Department of Physiology, 7620 Medical Science II, University of Michigan Medical School, 1301 E Catherine Street, Ann Arbor, MI 48109 0622, USA
    J Biol Chem 277:30998-1004. 2002
    ..Finally, we demonstrate that disruption of extracellular Wnt signaling by expression of secreted Frizzled related proteins causes spontaneous adipocyte conversion...
  19. ncbi Reduction of infarct size and prevention of cardiac rupture in transgenic mice overexpressing FrzA
    Laurent Barandon
    Department of Cardiovascular Surgery and Cardiology, Hopital Haut Leveque, Pessac, France
    Circulation 108:2282-9. 2003
    ..FrzA is involved in cell cycle control of vascular cells and angiogenesis. We assessed the hypothesis that FrzA could control the healing process after myocardial infarction (MI)...
  20. ncbi Wnt receptors and Wnt inhibitors are expressed in gradients in the developing telencephalon
    A S Kim
    Neurodevelopmental Disorders Laboratory, Department of Neurology, University of California, San Francisco, CA 94143 0435, USA
    Mech Dev 103:167-72. 2001
    ..In addition, SFRP-1 and SFRP-3 are expressed in opposing anterolateral to caudomedial gradients within the telencephalic ventricular zone throughout corticogenesis...
  21. ncbi Foxd1-dependent signals control cellularity in the renal capsule, a structure required for normal renal development
    Randy S Levinson
    Department of Urology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Development 132:529-39. 2005
    ....
  22. ncbi Place- and time-dependent expression of mouse sFRP-1 during development of the cerebral neocortex
    C Augustine
    Brain Development Laboratory, Howard Florey Institute, The University of Melbourne, Parkville, Victoria 3010, Australia
    Mech Dev 109:395-7. 2001
    ..We show that sFRP-1 mRNA expression is spatially restricted to the proliferative zones during the period, when neurons are known to be generated in large numbers for the enlarging cortical plate...
  23. pmc Scl represses cardiomyogenesis in prospective hemogenic endothelium and endocardium
    Ben Van Handel
    Department of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Cell 150:590-605. 2012
    ..These results reveal unexpected plasticity in embryonic endothelium such that loss of a single master regulator can induce ectopic cardiomyogenesis from endothelial cells...
  24. pmc Lhx2 regulates the timing of β-catenin-dependent cortical neurogenesis
    Lea Chia Ling Hsu
    Institute of Cellular and Organismic Biology, Academia Sinica, Taipei, 115, Taiwan Molecular Cell Biology, Taiwan International Graduate Program, Academia Sinica, Taipei, 115, Taiwan Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, 114, Taiwan
    Proc Natl Acad Sci U S A 112:12199-204. 2015
    ..Thus, we concluded that Lhx2 is required for β-catenin function in maintaining cortical progenitor proliferation and controls the timing of cortical neurogenesis. ..
  25. doi Estrogen-mediated signaling is differentially affected by the expression levels of Sfrp1 in mammary epithelial cells
    Kelly J Gregory
    Pioneer Valley Life Sciences Institute, Baystate Medical Center, Springfield, Massachusetts, 01199, USA
    Cell Biol Int 39:873-9. 2015
    ..Secreted frizzled-related proteins (SFRPs) are a family of Wnt signaling antagonists. Loss of Sfrp1 in mice results in focal ductal epithelial hyperplasias and in humans, loss of SFRP1 is associated with early ..
  26. pmc FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis
    Ji Hye Paik
    Department of Medical Oncology, Belfer Institute for Applied Cancer Science, Harvard Medical School, Boston, MA 02115, USA
    Cell Stem Cell 5:540-53. 2009
    ..Thus, the FoxO family coordinately regulates diverse genes and pathways to govern key aspects of NSC homeostasis in the mammalian brain...
  27. doi Secreted frizzled related proteins modulate pathfinding and fasciculation of mouse retina ganglion cell axons by direct and indirect mechanisms
    Severine Marcos
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas Universidad Autonoma de Madrid, Madrid 28049, Spain, Centro de Investigación Biomédica en Red de Enfermedades Raras, Madrid 28049, Spain, and Instituto Cajal, Consejo Superior de Investigaciones Cientificas, 28002 Madrid, Spain
    J Neurosci 35:4729-40. 2015
    ..Here, we show that the combination of these two functions well explain the axon guidance phenotype observed in Sfrp1 and Sfrp2 single and compound mouse mutant embryos, in which RGC axons make subtle but significant mistakes during ..
  28. doi SFRP1 and SFRP2 dose-dependently regulate midbrain dopamine neuron development in vivo and in embryonic stem cells
    Julianna Kele
    Laboratory of Molecular Neurobiology, Medical Biochemistry and Biophysics, Karolinska Institute, Scheeleväg 1, Stockholm, Sweden
    Stem Cells 30:865-75. 2012
    ..Here, we show that sFRP1 and sFRP2 activate the Wnt/planar-cell-polarity/Rac1 pathway in DA cells...
  29. pmc Maintenance of the bronchial alveolar stem cells in an undifferentiated state by secreted frizzled-related protein 1
    Takayuki Shiomi
    Department of Anesthesiology, College of Physicians and Surgeons, Columbia University, New York, New York, USA and
    FASEB J 28:5242-9. 2014
    ..Secreted frizzled-related protein 1 (SFRP1) is a critical molecule involved in alveolar duct formation in the lung and here we demonstrate its importance in ..
  30. pmc The effects of diet induced obesity on breast cancer associated pathways in mice deficient in SFRP1
    Kelly J Gauger
    Pioneer Valley Life Sciences Institute, Baystate Medical Center, 3601 Main St, Springfield, MA 01199, USA
    Mol Cancer 13:117. 2014
    ..Secreted frizzled-related proteins (SFRPs) are a family of proteins that block the Wnt signaling pathway and loss of Sfrp1 expression is observed in breast cancer...
  31. doi Hematopoietic stem cell fate decisions are regulated by Wnt antagonists: comparisons and current controversies
    Corey J Cain
    Quantitative and Systems Biology Graduate Program, School of Natural Sciences, University of California, Merced, CA 95343, USA
    Exp Hematol 41:3-16. 2013
    ....
  32. pmc Diverse Functions of Retinoic Acid in Brain Vascular Development
    Stephanie Bonney
    Department of Pediatrics, Section of Developmental Biology, University of Colorado, School of Medicine Anschutz Medical Campus Aurora, Colorado 80045
    J Neurosci 36:7786-801. 2016
    ..From this, a model emerges in which RA acts upstream of the WNT pathway via non-cell-autonomous and cell-autonomous mechanisms to ensure the formation of an adequate and stable brain vascular plexus...
  33. pmc Sfrp1 and Sfrp2 are not involved in Wnt/β-catenin signal silencing during lens induction but are required for maintenance of Wnt/β-catenin signaling in lens epithelial cells
    Yuki Sugiyama
    Save Sight Institute, The University of Sydney, Australia
    Dev Biol 384:181-93. 2013
    ..Here we show its closely-related isoform, Sfrp1, has a complimentary pattern of expression in the lens, being absent from the placode and epithelium but expressed ..
  34. ncbi sFRP-2 is a target of the Wnt-4 signaling pathway in the developing metanephric kidney
    B Lescher
    Max Planck Institut fur Immunbiologie, Abteilung für Molekulare Embryologie, Freiburg, Germany
    Dev Dyn 213:440-51. 1998
    ....
  35. doi Mutations in sFRP1 or sFRP4 are not a common cause of craniotubular hyperostosis
    Eveline Boudin
    Department of Medical Genetics, University and University Hospital of Antwerp, Edegem, Belgium
    Bone 52:292-5. 2013
    ..Studies using mice showed that two members of this family, sFRP1 and sFRP4, have an important effect on bone formation...
  36. pmc Strain-specific modifier genes governing craniofacial phenotypes
    Partha Mukhopadhyay
    University of Louisville Birth Defects Center, Department of Molecular, Cellular and Craniofacial Biology, ULSD, University of Louisville, Louisville, Kentucky 40292, USA
    Birth Defects Res A Clin Mol Teratol 94:162-75. 2012
    ..c-Ski is a transcriptional regulator. Ski(-/-) mice on a C57BL6J (B6) background exhibit facial clefting, while Ski(-/-) mice on a 129P3 (129) background present with exencephaly...
  37. pmc Pαx6 expression in postmitotic neurons mediates the growth of axons in response to SFRP1
    Alvaro Sebastián-Serrano
    Centro Nacional de Biotecnologia, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
    PLoS ONE 7:e31590. 2012
    ..Here, we demonstrate that Pax6 mediates the response of growing axons to SFRP1, a secreted molecule expressed in several Pax6-positive forebrain territories...
  38. pmc Wnt inhibitory factor 1 (Wif1) is regulated by androgens and enhances androgen-dependent prostate development
    Kimberly P Keil
    Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin Madison, Madison, WI 53706, USA
    Endocrinology 153:6091-103. 2012
    ....
  39. pmc Crucial roles of Foxa2 in mouse anterior-posterior axis polarization via regulation of anterior visceral endoderm-specific genes
    Chiharu Kimura-Yoshida
    Department of Molecular Embryology, Osaka Medical Center and Research Institute for Maternal and Child Health, Osaka Prefectural Hospital Organization, Murodo cho, Izumi, Osaka 594 1101, Japan
    Proc Natl Acad Sci U S A 104:5919-24. 2007
    ..These findings provide profound insights into conserved roles of Foxa2 transcription factors in anterior specification throughout the evolution of the chordate body plan...
  40. pmc Differential activity of Wnt/beta-catenin signaling in the embryonic mouse thalamus
    Krista K Bluske
    Department of Neuroscience, and Graduate Program in Neuroscience, Minneapolis, Minnesota 55455, USA
    Dev Dyn 238:3297-309. 2009
    ..Analysis of mice with enhanced or reduced Shh signal showed that Axin2 expression is similar to controls. These results suggest that differential Wnt signaling may play a role in patterning the thalamus independent of Shh signaling...
  41. pmc Enhanced striatal dopamine transmission and motor performance with LRRK2 overexpression in mice is eliminated by familial Parkinson's disease mutation G2019S
    Xianting Li
    Department of Neurology, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Neurosci 30:1788-97. 2010
    ..The PD-associated mutation G2019S may exert pathogenic effects by impairing these functions of LRRK2. Our LRRK2 BAC transgenic mice, therefore, could provide a useful model for understanding early PD pathological events...
  42. pmc The divergent roles of secreted frizzled related protein-1 (SFRP1) in lung morphogenesis and emphysema
    Robert Foronjy
    Department of Medicine, Columbia University, New York, New York, USA
    Am J Pathol 177:598-607. 2010
    ..This study demonstrates that SFRP1, an inhibitor of Wnt signaling normally expressed during lung embryogenesis, is induced in the lungs of emphysema ..
  43. ncbi Patched2 modulates tumorigenesis in patched1 heterozygous mice
    Youngsoo Lee
    Department of Genetics, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Cancer Res 66:6964-71. 2006
    ..Ptch1+/-Ptch2-/- and Ptch1+/-Ptch2+/- animals showed a higher incidence of tumors and a broader spectrum of tumor types compared with Ptch1+/- animals. Therefore, Ptch2 modulates tumorigenesis associated with Ptch1 haploinsufficiency...
  44. pmc Neuroretina specification in mouse embryos requires Six3-mediated suppression of Wnt8b in the anterior neural plate
    Wei Liu
    Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Clin Invest 120:3568-77. 2010
    ....
  45. pmc Compensation by tumor suppressor genes during retinal development in mice and humans
    Stacy L Donovan
    Department of Developmental Neurobiology, St, Jude Children s Research Hospital, Memphis, TN 38105, USA
    BMC Biol 4:14. 2006
    ..In this manuscript, we explore the different roles of the Rb family in human and mouse retinal development in order to better understand the species-specific difference in retinoblastoma susceptibility...
  46. pmc SMAD4-mediated WNT signaling controls the fate of cranial neural crest cells during tooth morphogenesis
    Jingyuan Li
    Center for Craniofacial Molecular Biology, Herman Ostrow School of Dentistry, University of Southern California, 2250 Alcazar Street, CSA 103, Los Angeles, CA 90033, USA
    Development 138:1977-89. 2011
    ..At the molecular level, loss of Smad4 results in downregulation of the WNT pathway inhibitors Dkk1 and Sfrp1 and in the upregulation of canonical WNT signaling, including increased β-catenin activity...
  47. pmc The role of sonic hedgehog-Gli2 pathway in the masculinization of external genitalia
    Shinichi Miyagawa
    Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, Japan
    Endocrinology 152:2894-903. 2011
    ..The current study identified hedgehog signaling pathway as a key factor not only for initial development but also for sexually dimorphic development of the external genitalia in coordination with androgen signaling...
  48. pmc Barx1-mediated inhibition of Wnt signaling in the mouse thoracic foregut controls tracheo-esophageal septation and epithelial differentiation
    Janghee Woo
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts, United States of America
    PLoS ONE 6:e22493. 2011
    ..Thus, as in the developing stomach, but distinct from the spleen, Barx1 control of thoracic foregut specification and tracheo-esophageal septation is tightly associated with down-regulation of adjacent Wnt pathway activity...
  49. doi Coordination of epithelial branching and salivary gland lumen formation by Wnt and FGF signals
    Nisha Patel
    Department of Craniofacial Development, Dental Institute, King s College London, Guy s Hospital, London Bridge, London, UK
    Dev Biol 358:156-67. 2011
    ..of canonical and non-canonical Wnt signaling in endbuds by FGF signaling occurs at least in part through sFRP1, a secreted inhibitor of Wnt signaling and downstream target of FGF signaling...
  50. ncbi Secreted frizzled related protein 1 regulates Wnt signaling for BMP2 induced chondrocyte differentiation
    Tripti Gaur
    Department of Cell Biology and Cancer Center, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Cell Physiol 208:87-96. 2006
    ..In this study, chondrogenesis is examined in a mouse model in which the Wnt antagonist secreted frizzled related protein 1 (sFRP1) is non-functional and results in a high bone mass phenotype and activation through the ..
  51. pmc Hox10 genes function in kidney development in the differentiation and integration of the cortical stroma
    Alisha R Yallowitz
    Department of Internal Medicine, Division of Molecular Medicine and Genetics University of Michigan, Ann Arbor, Michigan, United States of America
    PLoS ONE 6:e23410. 2011
    ....
  52. pmc Role of secreted frizzled-related protein 1 (SFRP1) in wound healing
    C H Li
    Department of Periodontology and Oral Biology, Goldman School of Dental Medicine, Boston University, Boston, MA 02118, USA
    J Dent Res 85:374-8. 2006
    ..Secreted frizzled-related protein 1 (SFRP1) contributes to the inhibition of apoptosis in fibroblast populations...
  53. ncbi Spatial gene expression in the T-stage mouse metanephros
    Georgina Caruana
    Department of Anatomy and Cell Biology, Monash University, Clayton, Vic, Australia
    Gene Expr Patterns 6:807-25. 2006
    ..This study has identified genes spatially expressed in regions of the developing kidney involved in branching morphogenesis, nephrogenesis and the development of the collecting duct system, calyces, renal pelvis and ureter...
  54. ncbi Identification of SFRP1 as a candidate mediator of stromal-to-epithelial signaling in prostate cancer
    Margaret S Joesting
    Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Cancer Res 65:10423-30. 2005
    ..Further investigation of one of these genes, secreted frizzled related protein 1 (SFRP1), revealed that its expression parallels prostatic growth with high expression during ..
  55. ncbi A gene-driven ENU-based approach to generating an allelic series in any gene
    Mohamed Mohideen Quwailid
    MRC Mammalian Genetics Unit, Medical Research Council, OX11 0RD, Harwell, Oxfordshire, UK
    Mamm Genome 15:585-91. 2004
    ..It is now available to academic collaborators as a community resource...
  56. ncbi Characterization of Wnt signaling components and activation of the Wnt canonical pathway in the murine retina
    Hong Liu
    Molecular Medicine Program, Ottawa Health Research Institute, Ottawa, Ontario, Canada
    Dev Dyn 227:323-34. 2003
    ....
  57. ncbi Functional ablation of the mouse Ldb1 gene results in severe patterning defects during gastrulation
    Mahua Mukhopadhyay
    Department of Anatomy, University of Wisconsin Madison Medical School, Madison, WI 53706, USA
    Development 130:495-505. 2003
    ..The expression of several Wnt inhibitors is curtailed in the mutant, suggesting that Wnt pathways may be involved in axial patterning regulated by Ldb1...
  58. ncbi Expression of Tcf/Lef and sFrp and localization of beta-catenin in the developing mouse lung
    M Tebar
    Department of Pulmonology, Leiden University Medical Center, NL 2300 RC, Leiden, The Netherlands
    Mech Dev 109:437-40. 2001
    ..5 onward), and adjacent mesenchyme. Tcf1, Lef1, Tcf3, Tcf4, sFrp1, sFrp2 and sFrp4 were also expressed in the PE, AE, and adjacent mesenchyme in specific spatio-temporal patterns.
  59. ncbi Expression pattern of mouse sFRP-1 and mWnt-8 gene during heart morphogenesis
    B Jaspard
    INSERM U441, Avenue du Haut Leveque, 33 600, Pessac, France
    Mech Dev 90:263-7. 2000
    ..Immunoprecipitation experiments demonstrates that FrzA binds to mWnt-8 in cell culture experiments...
  60. ncbi Expression pattern of two Frizzled-related genes, Frzb-1 and Sfrp-1, during mouse embryogenesis suggests a role for modulating action of Wnt family members
    B H Hoang
    Department of Orthopaedics, University Hospitals of Cleveland, Case Western Reserve University, Ohio 44106, USA
    Dev Dyn 212:364-72. 1998
    ..We conclude from these experiments that Frzb-1 is expressed at a time and location to modulate the action of Wnt family members during development of the limbs and central nervous system...
  61. pmc Soluble frizzled-related protein 1 is estrogen inducible in bone marrow stromal cells and suppresses the earliest events in lymphopoiesis
    Takafumi Yokota
    Department of Hematology and Oncology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    J Immunol 181:6061-72. 2008
    ..Bone-lining stromal cells express sFRP1, and the transcripts were elevated by pregnancy or estrogen injection...
  62. ncbi Inhibition of SFRP1 reduces severity of periodontitis
    C H Li
    Department of Periodontology and Oral Biology, Goldman School of Dental Medicine, Boston University, Boston, MA 02118, USA
    J Dent Res 86:873-7. 2007
    ..Secreted frizzled-related protein 1 (SFRP1) modulates apoptosis in different cell types. To characterize the roles of SFRP1 in periodontitis, we used a P...
  63. pmc Regulation of endothelial cell cytoskeletal reorganization by a secreted frizzled-related protein-1 and frizzled 4- and frizzled 7-dependent pathway: role in neovessel formation
    Pascale Dufourcq
    INSERM U828, Av du haut lévèque, 33600 Pessac, France
    Am J Pathol 172:37-49. 2008
    ..This study illustrates a regulated pathway by sFRP-1 involving GSK-3beta and Rac-1 in endothelial cell cytoskeletal reorganization and in neovessel formation...
  64. ncbi Bone anabolic effects of parathyroid hormone are blunted by deletion of the Wnt antagonist secreted frizzled-related protein-1
    Peter V N Bodine
    Women s Health and Musculoskeletal Biology, Wyeth Research, Collegeville, Pennsylvania 19426, USA
    J Cell Physiol 210:352-7. 2007
    ..Moreover, as the effects of sFRP-1 deletion on vBMD increase, the ability of PTH to enhance vBMD declines suggesting that there are overlapping mechanisms of action...
  65. doi Inhibition of myoblast differentiation by Sfrp1 and Sfrp2
    Simon Descamps
    INRA, UMR 866 Différenciation cellulaire et croissance, 2 place Viala, 34060 Montpellier, France
    Cell Tissue Res 332:299-306. 2008
    ..Here, we show that the addition of recombinant Sfrp1 or Sfrp2 to C2C12 cell line cultures or to primary cultures of satellite cells results in the inhibition of ..
  66. pmc Secreted frizzled related protein 1 is a paracrine modulator of epithelial branching morphogenesis, proliferation, and secretory gene expression in the prostate
    Margaret S Joesting
    Department of Genetics, Cellular Biology, and Development, University of Minnesota, Minneapolis, MN 55455, USA
    Dev Biol 317:161-73. 2008
    Previous in vitro studies identified secreted frizzled related protein 1 (SFRP1) as a candidate pro-proliferative signal during prostatic development and cancer progression...
  67. doi Secreted frizzled related protein 1 (Sfrp1) and Wnt signaling in innervated and denervated skeletal muscle
    Anna Svensson
    School of Pure and Applied Natural Sciences, University of Kalmar, 391 82 Kalmar, Sweden
    J Mol Histol 39:329-37. 2008
    ..Secreted frizzled-related proteins (Sfrps) such as Sfrp1 can function as inhibitors of Wnt signaling...
  68. doi Dkk1 and Wnt3 interact to control head morphogenesis in the mouse
    Samara L Lewis
    Children s Medical Research Institute, University of Sydney, Wentworthville, New South Wales, NSW 2145, Australia
    Development 135:1791-801. 2008
    ..These findings highlight that head development is sensitive to the level of WNT3 signalling and that DKK1 is the key antagonist that modulates WNT3 activity during anterior morphogenesis...
  69. ncbi c-kit delineates a distinct domain of progenitors in the developing kidney
    Kai M Schmidt-Ott
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Dev Biol 299:238-49. 2006
    ..These data suggest that ureteric bud-derived SCF elicits growth-promoting effects in the metanephric kidney by expanding one or more components of the interstitial c-kit-positive progenitor pool...
  70. doi Effect of canonical Wnt inhibition in the neurogenic cortex, hippocampus, and premigratory dentate gyrus progenitor pool
    Nina Solberg
    Section for Cellular and Genetic Therapy, Institute of Microbiology, Rikshospitalet, Oslo, Norway
    Dev Dyn 237:1799-811. 2008
    ..The lower number of progenitors in the dentate gyrus was not rescued after migration to the subgranular zone and thus the dentate gyrus lacked the entire internal blade and a part of the external blade from postnatal to adult stages...
  71. pmc Identification of Phox2b-regulated genes by expression profiling of cranial motoneuron precursors
    Patrick Pla
    Ecole Normale Superieure, Departement de Biologie, 75005 Paris, France
    Neural Dev 3:14. 2008
    ..How Phox2b exerts its pleiotropic functions, both as a proneural gene and a neuronal subtype determinant, has remained unknown...
  72. doi Syndactyly and preaxial synpolydactyly in the single Sfrp2 deleted mutant mice
    Masaya Ikegawa
    Department of Genomic Medical Sciences, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Dev Dyn 237:2506-17. 2008
    ..Although joint formation was not disrupted, chondrocyte maturation was preaxially disturbed. Our results suggest that the Sfrp2 deleted mice can be a useful animal model to study human syndactyly/preaxial synpolydactyly defects...
  73. doi Sfrp1 and Sfrp2 are required for normal male sexual development in mice
    Nick Warr
    Mammalian Genetics Unit, MRC Harwell, Harwell Science and Innovation Campus, Oxfordshire, UK
    Dev Biol 326:273-84. 2009
    ..Using in vivo loss-of-function studies we report here for the first time a redundant role for Sfrp1 and Sfrp2 in embryonic sexual development of the mouse. At 16...
  74. doi Conserved gene expression programs integrate mammalian prostate development and tumorigenesis
    Colin Pritchard
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Cancer Res 69:1739-47. 2009
    ..These results indicate that components of normal developmental processes are active in prostate neoplasia and provide further rationale for exploiting molecular features of organogenesis to understand cancer phenotypes...
  75. doi A small molecule inhibitor of the Wnt antagonist secreted frizzled-related protein-1 stimulates bone formation
    Peter V N Bodine
    Women s Health and Musculoskeletal Biology, Wyeth Research, 500 Arcola Road, Collegeville, PA 19426, USA
    Bone 44:1063-8. 2009
    ..0001 microM. This work demonstrates the feasibility of developing small molecules that inhibit sFRP-1 and stimulate canonical Wnt signaling to increase bone formation...
  76. pmc Motor neurons with axial muscle projections specified by Wnt4/5 signaling
    Dritan Agalliu
    Howard Hughes Medical Institute, Kavli Institute for Brain Science, Departments of Neuroscience and Biochemistry and Molecular Biophysics, Columbia University Medical Center, New York, NY 10032, USA
    Neuron 61:708-20. 2009
    ..Thus, two dorsoventral signaling pathways, mediated by Shh and Wnt4/5, are required to establish an early binary divergence in motor neuron columnar identity...
  77. pmc Sfrp controls apicobasal polarity and oriented cell division in developing gut epithelium
    Makoto Matsuyama
    Vertebrate Body Plan, Center for Developmental Biology, RIKEN Kobe, Minatojima Minami, Kobe, Japan
    PLoS Genet 5:e1000427. 2009
    ..Here, we show that inactivation of Sfrp1 and Sfrp2 leads to reduction in fore-stomach length in mouse embryos, which is enhanced in the presence of the ..
  78. pmc Secreted frizzled related protein 1 is a target to improve fracture healing
    Tripti Gaur
    Department of Cell Biology and Cancer Center, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    J Cell Physiol 220:174-81. 2009
    ..b>Secreted frizzled related protein 1 (sFRP1) is one of several Wnt antagonists and among the loss-of-function mouse models in which 32-..
  79. pmc FGF-regulated BMP signaling is required for eyelid closure and to specify conjunctival epithelial cell fate
    Jie Huang
    Department of Ophthalmology and Visual Sciences, Washington University, St Louis, MO 63130, USA
    Development 136:1741-50. 2009
    ..FGF signaling also promoted the expression of the Wnt antagonist Sfrp1 and suppressed Wnt signaling in the prospective eyelid epithelial cells, independently of BMP function...
  80. pmc WNT signaling enhances breast cancer cell motility and blockade of the WNT pathway by sFRP1 suppresses MDA-MB-231 xenograft growth
    Yutaka Matsuda
    Friedrich Miescher Institute for Biomedical Research Part of the Novartis Research Foundation, Basel, Switzerland
    Breast Cancer Res 11:R32. 2009
    ..Moreover, many breast tumors show hypermethylation of the secreted Frizzled-related protein 1 (sFRP1) promoter region, causing low expression of this WNT antagonist...
  81. pmc c-Myc transforms human mammary epithelial cells through repression of the Wnt inhibitors DKK1 and SFRP1
    Victoria H Cowling
    Dartmouth Medical School, Norris Cotton Cancer Center, One Medical Center Drive, Lebanon, NH 03756, USA
    Mol Cell Biol 27:5135-46. 2007
    ..c-Myc suppresses the Wnt inhibitors DKK1 and SFRP1, and derepression of DKK1 or SFRP1 reduces Myc-dependent transforming activity...
  82. doi Secreted frizzled-related protein 1 extrinsically regulates cycling activity and maintenance of hematopoietic stem cells
    Jonas Renström
    3rd Department of Internal Medicine, Klinikum rechts der Isar, Munich, Germany
    Cell Stem Cell 5:157-67. 2009
    Secreted frizzled-related protein 1 (Sfrp1) is highly expressed by stromal cells maintaining hematopoietic stem cells (HSCs)...
  83. ncbi Mouse homologues of Shisa antagonistic to Wnt and Fgf signalings
    Kenryo Furushima
    Laboratory for Animal Resources and Genetic Engineering, Center for Developmental Biology CDB, RIKEN Kobe, 2 2 3 Minatojima minami, Chuo Ku, Kobe 650 0047, Japan
    Dev Biol 306:480-92. 2007
    ....
  84. doi Wnt modulators, SFRP-1, and SFRP-2 are expressed in osteoblasts and differentially regulate hematopoietic stem cells
    Hideaki Nakajima
    Division of Hematology, Department of Internal Medicine, Keio University School of Medicine, Tokyo 160 8582, Japan
    Biochem Biophys Res Commun 390:65-70. 2009
    ..These results indicate that although both SFRP-1 and SFRP-2 act as inhibitors for Wnt signaling in vitro, they differentially affect the homeostasis of HSCs...
  85. ncbi Wnt3a binds to several sFRPs in the nanomolar range
    Danuta Wawrzak
    Laboratory for Cell Genetics, Vrije Universiteit Brussel VUB, Pleinlaan 2, B 1050 Brussels, Belgium
    Biochem Biophys Res Commun 357:1119-23. 2007
    ..Here we show, using surface plasmon resonance and purified proteins, that sFRP1, sFRP2, sFRP4, and Frzb bind directly to Wnt3a with affinities in the nanomolar range...
  86. ncbi SHH-N upregulates Sfrp2 to mediate its competitive interaction with WNT1 and WNT4 in the somitic mesoderm
    C S Lee
    Department of Embryology, Carnegie Institution of Washington, Baltimore, MD 21210, USA
    Development 127:109-18. 2000
    ..Together, our results support the model that SHH-N at least in part employs SFRP2 to reduce WNT1/4 activity in the somitic mesoderm...
  87. pmc Smad-interacting protein-1 (Zfhx1b) acts upstream of Wnt signaling in the mouse hippocampus and controls its formation
    Amaya Miquelajauregui
    Max Planck Institute for Experimental Medicine, Hermann Rein Strasse 3, 37075 Gottingen, Germany
    Proc Natl Acad Sci U S A 104:12919-24. 2007
    ..The expression of the Wnt antagonist Sfrp1 was ectopically activated, whereas the activity of the noncanonical Wnt effector, JNK, was down-regulated in the ..
  88. ncbi Secreted Frizzled-related proteins: searching for relationships and patterns
    Steve E Jones
    Retinitis Pigmentosa Research Unit, Division of Pharmacology and Theraputics, GKT School of Biomedical Sciences, The Rayne Institute, St Thomas Hospital, London UK
    Bioessays 24:811-20. 2002
    ....
  89. ncbi Mbd3, a component of the NuRD co-repressor complex, is required for development of pluripotent cells
    Keisuke Kaji
    Institute for Stem Cell Research, Centre Development in Stem Cell Biology, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JQ, UK
    Development 134:1123-32. 2007
    ....
  90. doi Lens morphogenesis is dependent on Pax6-mediated inhibition of the canonical Wnt/beta-catenin signaling in the lens surface ectoderm
    Ondrej Machon
    Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, 14420 Prague 4, Czech Republic
    Genesis 48:86-95. 2010
    ..We show that Pax6 directly controls expression of several Wnt inhibitors such as Sfrp1, Sfrp2, and Dkk1 in the presumptive lens...
  91. ncbi Neuronal production and precursor proliferation defects in the neocortex of mice with loss of function in the canonical Wnt signaling pathway
    C J Zhou
    Department of Neurology, UCSF Mission Bay, Box 2722, Rock Hall, 1550 Fourth Street, Room RH 348D, San Francisco, CA 94143 2722, USA
    Neuroscience 142:1119-31. 2006
    ..This analysis demonstrates that canonical Wnt signaling is required for a diverse array of developmental processes in the neocortex in addition to the previously known roles in regulating precursor proliferation and patterning...
  92. doi A critical role for sFRP proteins in maintaining caudal neural tube closure in mice via inhibition of BMP signaling
    Kamana Misra
    Department of Neuroscience and Cell Biology, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, 675 Hoes Lane, Piscataway, NJ 08854, USA
    Dev Biol 337:74-83. 2010
    ..In this study, we provide genetic and functional evidence that the secreted sFRP1 and sFRP2 proteins, which have been primarily implicated as negative regulators of Wnt signaling, can also ..
  93. ncbi The stomach mesenchymal transcription factor Barx1 specifies gastric epithelial identity through inhibition of transient Wnt signaling
    Byeong Moo Kim
    Department of Medical Oncology, Dana Farber Cancer Institute, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Dev Cell 8:611-22. 2005
    ..Barx1 directs mesenchymal cell expression of two secreted Wnt antagonists, sFRP1 and sFRP2, and these factors are sufficient replacements for Barx1 function...