Sema4b

Summary

Gene Symbol: Sema4b
Description: sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B
Alias: SemC, Semac, mKIAA1745, semaphorin-4B, sema C, semaphorin-C
Species: mouse

Top Publications

  1. ncbi Plexin-B2 controls the development of cerebellar granule cells
    Roland H Friedel
    Department of Biological Sciences, Howard Hughes Medical Institute, Stanford University, Stanford, California 94305, USA
    J Neurosci 27:3921-32. 2007
  2. pmc Semaphorin 4C and 4G are ligands of Plexin-B2 required in cerebellar development
    Viola Maier
    Institute of Developmental Genetics, Helmholtz Center Munich, Neuherberg, Germany
    Mol Cell Neurosci 46:419-31. 2011
  3. pmc An antagonistic interaction between PlexinB2 and Rnd3 controls RhoA activity and cortical neuron migration
    Roberta Azzarelli
    1 Division of Molecular Neurobiology, MRC National Institute for Medical Research, Mill Hill, London NW7 1AA, UK 2
    Nat Commun 5:3405. 2014
  4. doi Semaphorin-Plexin Signaling Controls Mitotic Spindle Orientation during Epithelial Morphogenesis and Repair
    Jingjing Xia
    Department of Pharmacology, Max Planck Institute for Heart and Lung Research, 61231 Bad Nauheim, Germany
    Dev Cell 33:299-313. 2015
  5. pmc Astrogliosis Induced by Brain Injury Is Regulated by Sema4B Phosphorylation(123)
    Liat Ben-Gigi
    Department of Developmental Biology and Cancer Research, Institute of Medical Research Israel Canada IMRIC, Faculty of Medicine, The Hebrew University, Jerusalem 91120, Israel
    Eneuro 2:. 2015
  6. ncbi Murine semaphorin D/collapsin is a member of a diverse gene family and creates domains inhibitory for axonal extension
    A W Puschel
    Abteilung Neurochemie Max Planck Institut für Hirnforschung, Frankfurt am Main, Federal Republic of Germany
    Neuron 14:941-8. 1995
  7. ncbi Semaphorin III can function as a selective chemorepellent to pattern sensory projections in the spinal cord
    E K Messersmith
    Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA
    Neuron 14:949-59. 1995
  8. ncbi The sensory innervation of the mouse spinal cord may be patterned by differential expression of and differential responsiveness to semaphorins
    A W Puschel
    Abteilung Neurochemie, Max Planck Institut für Hirnforschung, Frankfurt Main, Germany
    Mol Cell Neurosci 7:419-31. 1996
  9. ncbi Identification of a novel transmembrane semaphorin expressed on lymphocytes
    T Furuyama
    Department of Anatomy and Neuroscience, Osaka University Medical School, 2 2 Yamadaoka, Suita Shi, Osaka 565, Japan
    J Biol Chem 271:33376-81. 1996
  10. ncbi Neuropilin is a receptor for the axonal chemorepellent Semaphorin III
    Z He
    Howard Hughes Medical Institute, Department of Anatomy, University of California, San Francisco 94143 0452, USA
    Cell 90:739-51. 1997

Scientific Experts

  • Roland H Friedel
  • Atsushi Kumanogoh
  • Jingjing Xia
  • Liat Ben-Gigi
  • Roberta Azzarelli
  • Viola Maier
  • Yukinobu Nakagawa
  • Helen Rayburn
  • Marc Tessier-Lavigne
  • Constanze Burkhardt
  • C Lillesaar
  • Thomas Worzfeld
  • Tianliang Sun
  • Timo Franz
  • Roberto D Polakiewicz
  • Sahar Sweetat
  • Giuseppina Federico
  • Yakov Fellig
  • Oded Behar
  • Ivana Matković
  • Cord H Brakebusch
  • Inmaculada Bañón-Rodríguez
  • Fernando Martin-Belmonte
  • Stefan Offermanns
  • Thorsten Wiederhold
  • Elazar Besser
  • Hermann Josef Grone
  • Jakub M Swiercz
  • Anne J Ridley
  • Philippe Riou
  • Debbie van den Berg
  • Ritu Garg
  • Patricia Garcez
  • Francois Guillemot
  • Emilie Pacary
  • Maddy Parsons
  • A W Puschel
  • Sujin Kang
  • Toshihiko Toyofuku
  • Tetsuya Kimura
  • Ichiro Katayama
  • Hyota Takamatsu
  • Tatsuki R Kataoka
  • Wolfgang Wurst
  • Christine Jolicoeur
  • Tatsusada Okuno
  • Hitoshi Kikutani
  • Noriko Takegahara
  • Masahito Ikawa
  • Satoshi Nojima
  • L h Wang
  • Geraldine Kerjan
  • Ulrich Schüller
  • Alain Chedotal
  • Constantino Sotelo
  • Eckart D Gundelfinger
  • Anja Badde
  • Craig C Garner
  • Myriam Müller
  • Andreas W Püschel
  • Z He
  • K Fried
  • M Tessier-Lavigne
  • T Furuyama
  • H Betz
  • R H Adams
  • E K Messersmith
  • R G Kalb
  • S M Strittmatter
  • T Hamaoka
  • A Kosugi
  • Y Iwahashi
  • M Ogata
  • S Saitoh
  • N Miyazaki
  • S Inagaki
  • S Noda
  • M Tohyama
  • E D Leonardo
  • A L Kolodkin
  • C S Goodman
  • C J Shatz

Detail Information

Publications15

  1. ncbi Plexin-B2 controls the development of cerebellar granule cells
    Roland H Friedel
    Department of Biological Sciences, Howard Hughes Medical Institute, Stanford University, Stanford, California 94305, USA
    J Neurosci 27:3921-32. 2007
    ..Many differentiated granule cells migrate inside the cerebellum and keep proliferating. These results reveal that Plexin-B2 controls the balance between proliferation and differentiation in granule cells...
  2. pmc Semaphorin 4C and 4G are ligands of Plexin-B2 required in cerebellar development
    Viola Maier
    Institute of Developmental Genetics, Helmholtz Center Munich, Neuherberg, Germany
    Mol Cell Neurosci 46:419-31. 2011
    ....
  3. pmc An antagonistic interaction between PlexinB2 and Rnd3 controls RhoA activity and cortical neuron migration
    Roberta Azzarelli
    1 Division of Molecular Neurobiology, MRC National Institute for Medical Research, Mill Hill, London NW7 1AA, UK 2
    Nat Commun 5:3405. 2014
    ..Thus, an interaction between the cell-extrinsic Plexin signalling pathway and the cell-intrinsic Ascl1-Rnd3 pathway determines the level of RhoA activity appropriate for cortical neuron migration. ..
  4. doi Semaphorin-Plexin Signaling Controls Mitotic Spindle Orientation during Epithelial Morphogenesis and Repair
    Jingjing Xia
    Department of Pharmacology, Max Planck Institute for Heart and Lung Research, 61231 Bad Nauheim, Germany
    Dev Cell 33:299-313. 2015
    ..Our data uncover semaphorin-plexin signaling as a central regulatory mechanism of mitotic spindle orientation necessary for the alignment of epithelial cell divisions with the epithelial plane. ..
  5. pmc Astrogliosis Induced by Brain Injury Is Regulated by Sema4B Phosphorylation(123)
    Liat Ben-Gigi
    Department of Developmental Biology and Cancer Research, Institute of Medical Research Israel Canada IMRIC, Faculty of Medicine, The Hebrew University, Jerusalem 91120, Israel
    Eneuro 2:. 2015
    ..Here, we show that astrocyte activation was altered and proliferation was reduced in Semaphorin 4B (Sema4B)-deficient mice following injury...
  6. ncbi Murine semaphorin D/collapsin is a member of a diverse gene family and creates domains inhibitory for axonal extension
    A W Puschel
    Abteilung Neurochemie Max Planck Institut für Hirnforschung, Frankfurt am Main, Federal Republic of Germany
    Neuron 14:941-8. 1995
    ..Our data demonstrate that semaphorins are a diverse family of molecules that may provide local signals to specify territories nonaccessible for growing axons...
  7. ncbi Semaphorin III can function as a selective chemorepellent to pattern sensory projections in the spinal cord
    E K Messersmith
    Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA
    Neuron 14:949-59. 1995
    ..These results suggest that semaphorin III functions to pattern sensory projections by selectively repelling axons that normally terminate dorsally...
  8. ncbi The sensory innervation of the mouse spinal cord may be patterned by differential expression of and differential responsiveness to semaphorins
    A W Puschel
    Abteilung Neurochemie, Max Planck Institut für Hirnforschung, Frankfurt Main, Germany
    Mol Cell Neurosci 7:419-31. 1996
    ..5. This suggests that Sem D may be involved in preventing an early penetration of the spinal cord by sensory afferents and subsequently shaping their lamina-specific termination...
  9. ncbi Identification of a novel transmembrane semaphorin expressed on lymphocytes
    T Furuyama
    Department of Anatomy and Neuroscience, Osaka University Medical School, 2 2 Yamadaoka, Suita Shi, Osaka 565, Japan
    J Biol Chem 271:33376-81. 1996
    ..M-sema G is most closely related to M-sema F, which we previously reported, and semB and semC. These four members appear to constitute a transmembrane type subfamily in mouse semaphorins...
  10. ncbi Neuropilin is a receptor for the axonal chemorepellent Semaphorin III
    Z He
    Howard Hughes Medical Institute, Department of Anatomy, University of California, San Francisco 94143 0452, USA
    Cell 90:739-51. 1997
    ..These results provide evidence that neuropilin is a receptor or a component of a receptor complex that mediates the effects of Sema III on these axons...
  11. ncbi A PDZ protein regulates the distribution of the transmembrane semaphorin, M-SemF
    L h Wang
    Department of Neurology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Biol Chem 274:14137-46. 1999
    ..While SEMCAP-1(GIPC) also interacts with SemC, it does not interact with other proteins containing a class I PDZ binding motif, nor does M-SemF interact with ..
  12. ncbi Neurites from trigeminal ganglion explants grown in vitro are repelled or attracted by tooth-related tissues depending on developmental stage
    C Lillesaar
    Division of Cell Biology, Department of Biomedicine and Surgery, Faculty of Health Sciences, Linkoping University, SE 581 85 Linkoping, Sweden
    Neuroscience 125:149-61. 2004
    ..We conclude that developing mandibular/dental mesenchyme can inhibit/repel neurite growth in vitro. Our results support the hypothesis that semaphorins may be involved in this interaction...
  13. ncbi Semaphorin 4B interacts with the post-synaptic density protein PSD-95/SAP90 and is recruited to synapses through a C-terminal PDZ-binding motif
    Constanze Burkhardt
    Abt Molekularbiologie, Institut fur Allgemeine Zoologie und Genetik, Westfalische Wilhelms Universitat, Schlossplatz 5, D 48149 Munster, Germany
    FEBS Lett 579:3821-8. 2005
    ..This sequence mediates the interaction with the post-synaptic density protein PSD-95/SAP90. Co-expression of Sema4B with PSD-95 in COS 7 cells results in the clustering of Sema4B...
  14. doi Identification of semaphorin 4B as a negative regulator of basophil-mediated immune responses
    Yukinobu Nakagawa
    Department of Immunopathology, World Premier International Immunology Frontier Research Center, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 565 0871, Japan
    J Immunol 186:2881-8. 2011
    ..In this article, we show that a class IV semaphorin, Sema4B, negatively regulates basophil functions through T cell-basophil contacts...