Scgb1a1

Summary

Gene Symbol: Scgb1a1
Description: secretoglobin, family 1A, member 1 (uteroglobin)
Alias: CC10, CC16, CCSP, PCB-BP, UGB, Utg, uteroglobin, Blastokinin, CCPBP, PCB-binding protein, clara cell 17 kDa protein, clara cell phospholipid-binding protein, clara cell secretory protein, clara cells 10 kDa secretory protein, secretoglobin family 1A member 1
Species: mouse

Top Publications

  1. ncbi Clara cell secretory protein deficiency increases oxidant stress response in conducting airways
    G W Mango
    Department of Environmental Medicine, University of Rochester, School of Medicine and Dentistry, Rochester, New York 14642, USA
    Am J Physiol 275:L348-56. 1998
  2. pmc The divergent roles of secreted frizzled related protein-1 (SFRP1) in lung morphogenesis and emphysema
    Robert Foronjy
    Department of Medicine, Columbia University, New York, New York, USA
    Am J Pathol 177:598-607. 2010
  3. pmc Eyes absent 1 (Eya1) is a critical coordinator of epithelial, mesenchymal and vascular morphogenesis in the mammalian lung
    Ahmed H K El-Hashash
    Developmental Biology and Regenerative Medicine Program, Saban Research Institute, Childrens Hospital Los Angeles, Keck School of Medicine of University of Southern California, 4650 Sunset Boulevard MS35, Los Angeles, CA 90027, USA
    Dev Biol 350:112-26. 2011
  4. pmc In vivo role of different domains and of phosphorylation in the transcription factor Nkx2-1
    Daniel Silberschmidt
    Stazione Zoologica Anton Dohrn, Villa Comunale, 80121, Napoli, Italy
    BMC Dev Biol 11:9. 2011
  5. ncbi Increased susceptibility of mice lacking Clara cell 10-kDa protein to lung tumorigenesis by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, a potent carcinogen in cigarette smoke
    Yongping Yang
    Cell and Cancer Biology Branch, Center for Cancer Research, NCI, National Institutes of Health, Rockville, Maryland 20850, USA
    J Biol Chem 279:29336-40. 2004
  6. ncbi UGRP1, a uteroglobin/Clara cell secretory protein-related protein, is a novel lung-enriched downstream target gene for the T/EBP/NKX2.1 homeodomain transcription factor
    T Niimi
    Laboratory of Metabolism, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
    Mol Endocrinol 15:2021-36. 2001
  7. ncbi Severe fibronectin-deposit renal glomerular disease in mice lacking uteroglobin
    Z Zhang
    Section on Developmental Genetics, Heritable Disorders Branch, National Institute of Child Health and Human Development NICHD, National Insitutes of Health NIH, Bethesda, MD 20892 1830, USA
    Science 276:1408-12. 1997
  8. ncbi Defects in tracheoesophageal and lung morphogenesis in Nkx2.1(-/-) mouse embryos
    P Minoo
    Department of Pediatrics, Women s and Children s Hospital, Los Angeles, California 90033, USA
    Dev Biol 209:60-71. 1999
  9. ncbi HNF-3/forkhead homologue-4 (HFH-4) is expressed in ciliated epithelial cells in the developing mouse lung
    J W Tichelaar
    Division of Pulmonary Biology, Children s Hospital Medical Center, Cincinnati, Ohio, USA
    J Histochem Cytochem 47:823-32. 1999
  10. ncbi Uteroglobin: a novel cytokine?
    A B Mukherjee
    Section on Developmental Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 1830, USA
    Cell Mol Life Sci 55:771-87. 1999

Research Grants

Scientific Experts

Detail Information

Publications142 found, 100 shown here

  1. ncbi Clara cell secretory protein deficiency increases oxidant stress response in conducting airways
    G W Mango
    Department of Environmental Medicine, University of Rochester, School of Medicine and Dentistry, Rochester, New York 14642, USA
    Am J Physiol 275:L348-56. 1998
    ..We have generated mice that are deficient in Clara cell secretory protein (CCSP -/-) and that exhibit an oxidant-sensitive phenotype...
  2. pmc The divergent roles of secreted frizzled related protein-1 (SFRP1) in lung morphogenesis and emphysema
    Robert Foronjy
    Department of Medicine, Columbia University, New York, New York, USA
    Am J Pathol 177:598-607. 2010
    ..Thus, SFRP1 induction during tissue injury is unlikely to contribute to the repair response but rather is a participatory factor in the pathogenesis of emphysema and tissue destruction...
  3. pmc Eyes absent 1 (Eya1) is a critical coordinator of epithelial, mesenchymal and vascular morphogenesis in the mammalian lung
    Ahmed H K El-Hashash
    Developmental Biology and Regenerative Medicine Program, Saban Research Institute, Childrens Hospital Los Angeles, Keck School of Medicine of University of Southern California, 4650 Sunset Boulevard MS35, Los Angeles, CA 90027, USA
    Dev Biol 350:112-26. 2011
    ..We conclude, therefore, that Eya1 function is critical for proper coordination of lung epithelial, mesenchymal and vascular development...
  4. pmc In vivo role of different domains and of phosphorylation in the transcription factor Nkx2-1
    Daniel Silberschmidt
    Stazione Zoologica Anton Dohrn, Villa Comunale, 80121, Napoli, Italy
    BMC Dev Biol 11:9. 2011
    ..We have generated mouse mutant strains to assess the roles of the two activation domains and of phosphorylation in mouse development and differentiation...
  5. ncbi Increased susceptibility of mice lacking Clara cell 10-kDa protein to lung tumorigenesis by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, a potent carcinogen in cigarette smoke
    Yongping Yang
    Cell and Cancer Biology Branch, Center for Cancer Research, NCI, National Institutes of Health, Rockville, Maryland 20850, USA
    J Biol Chem 279:29336-40. 2004
    ..tobacco smoke and lung tumorigenesis are associated with drastically reduced levels of Clara cell 10-kDa protein (CC10), a multifunctional secreted protein, naturally produced by the airway epithelia of virtually all mammals...
  6. ncbi UGRP1, a uteroglobin/Clara cell secretory protein-related protein, is a novel lung-enriched downstream target gene for the T/EBP/NKX2.1 homeodomain transcription factor
    T Niimi
    Laboratory of Metabolism, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
    Mol Endocrinol 15:2021-36. 2001
    ..protein, forms a homodimer, and exhibits an amino acid sequence similar to that seen in the uteroglobin/Clara cell secretory protein family of proteins...
  7. ncbi Severe fibronectin-deposit renal glomerular disease in mice lacking uteroglobin
    Z Zhang
    Section on Developmental Genetics, Heritable Disorders Branch, National Institute of Child Health and Human Development NICHD, National Insitutes of Health NIH, Bethesda, MD 20892 1830, USA
    Science 276:1408-12. 1997
    Despite myriads of biological activities ascribed to uteroglobin (UG), a steroid-inducible secreted protein, its physiological functions are unknown...
  8. ncbi Defects in tracheoesophageal and lung morphogenesis in Nkx2.1(-/-) mouse embryos
    P Minoo
    Department of Pediatrics, Women s and Children s Hospital, Los Angeles, California 90033, USA
    Dev Biol 209:60-71. 1999
    ..These results demonstrate a critical role for Nkx2.1 in morphogenesis of the anterior foregut and the lung as well as in differentiation of pulmonary epithelial cells...
  9. ncbi HNF-3/forkhead homologue-4 (HFH-4) is expressed in ciliated epithelial cells in the developing mouse lung
    J W Tichelaar
    Division of Pulmonary Biology, Children s Hospital Medical Center, Cincinnati, Ohio, USA
    J Histochem Cytochem 47:823-32. 1999
    ..Cellular sites of HFH-4 and beta-tubulin IV expression were distinct from that of Clara cell secretory protein (CCSP), which was detected in nonciliated epithelial cells in the conducting airway of the lung...
  10. ncbi Uteroglobin: a novel cytokine?
    A B Mukherjee
    Section on Developmental Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 1830, USA
    Cell Mol Life Sci 55:771-87. 1999
    b>Blastokinin or uteroglobin (UG) is a steroid-inducible, evolutionarily conserved, multifunctional protein secreted by the mucosal epithelial of virtually all mammals. It is present in the blood and in other body fluids including urine...
  11. ncbi Forkhead transcription factor HFH-4 expression is temporally related to ciliogenesis
    E N Blatt
    Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    Am J Respir Cell Mol Biol 21:168-76. 1999
    ....
  12. ncbi The transcription factor GATA6 is essential for branching morphogenesis and epithelial cell differentiation during fetal pulmonary development
    R Keijzer
    Department of Cell Biology and Genetics, Erasmus University Medical Centre Rotterdam, Rotterdam, The Netherlands
    Development 128:503-11. 2001
    ..TTF1 expression is unaltered in chimeric lungs whereas SPC and CC10 expression are attenuated in abnormally branched areas of chimeric lungs...
  13. ncbi Branching and differentiation defects in pulmonary epithelium with elevated Gata6 expression
    M Koutsourakis
    Department of Cell Biology and Genetics, Erasmus University Medical Centre Rotterdam, P O Box 1738, 3000 DR, The, Rotterdam, Netherlands
    Mech Dev 105:105-14. 2001
    ..Thus, elevated levels of GATA6 protein affect early lung development and in analogy to other GATA factors in other tissues, GATA6 also plays a crucial role in the terminal differentiation in this case of the distal pulmonary epithelium...
  14. ncbi Cutting edge: altered pulmonary eosinophilic inflammation in mice deficient for Clara cell secretory 10-kDa protein
    L C Chen
    Johns Hopkins Asthma and Allergy Center, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    J Immunol 167:3025-8. 2001
    b>Clara cell secretory protein (CC10) is a steroid-inducible protein, and its in vivo function is currently unclear. The role of CC10 in modulation of pulmonary allergic inflammation was examined in mice deficient for the CC10 gene...
  15. ncbi GATA6 regulates differentiation of distal lung epithelium
    Honghua Yang
    Department of Medicine, Molecular Cardiology Research Center, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Development 129:2233-46. 2002
    ..Together, these data implicate GATA6 as an important regulator of distal epithelial cell differentiation and proximal airway development in the mouse...
  16. ncbi Wnt5a participates in distal lung morphogenesis
    Changgong Li
    Department of Pediatrics, Women s and Children s Hospital, Los Angeles, CA 90033, USA
    Dev Biol 248:68-81. 2002
    ..Absence of WNT5a activity in the mutant lungs leads to increased expression of Fgf-10, Bmp4, Shh, and its receptor Ptc, raising the possibility that WNT5a, FGF-10, BMP4, and SHH signaling pathways are functionally interactive...
  17. ncbi TTF-1 phosphorylation is required for peripheral lung morphogenesis, perinatal survival, and tissue-specific gene expression
    Mario DeFelice
    Stazione Zoologica A Dohrn, Villa Comunale, 80121 Naples, Italy
    J Biol Chem 278:35574-83. 2003
    ..Direct and indirect transcriptional targets of TTF-1 were identified that are likely to play important roles in lung formation and function...
  18. ncbi beta-Catenin is required for specification of proximal/distal cell fate during lung morphogenesis
    Michael L Mucenski
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    J Biol Chem 278:40231-8. 2003
    ..These observations establish, for the first time, both the sites and timing of specification of the proximal and peripheral airways in the developing lung, and that beta-catenin is one of the essential components of this specification...
  19. ncbi Foxj1 is required for apical localization of ezrin in airway epithelial cells
    Tao Huang
    Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    J Cell Sci 116:4935-45. 2003
    ..These findings indicate that Foxj1 regulates ERM proteins differentially to selectively direct the apical localization of ezrin for the organization of multi-protein complexes in apical membranes of airway epithelial cells...
  20. pmc Hyperactive Wnt signaling changes the developmental potential of embryonic lung endoderm
    Tadashi Okubo
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    J Biol 3:11. 2004
    ..The full range of effects of this pathway, which includes the transcription factor Lef1, has not been explored, however...
  21. ncbi Notch in lung development and lung cancer
    Brendan J Collins
    Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
    Semin Cancer Biol 14:357-64. 2004
    ..Non-small cell lung cancers, including adenocarcinoma, appear to actively utilize this conserved developmental pathway. Pharmacologic inhibition of the Notch pathway is a potential experimental approach to lung cancer treatment...
  22. ncbi Regulation of TH2 responses by the pulmonary Clara cell secretory 10-kd protein
    Chih Hsing Hung
    Johns Hopkins Asthma and Allergy Center, Johns Hopkins University School of Medicine, Baltimore, MD 21224 6801, USA
    J Allergy Clin Immunol 114:664-70. 2004
    Pulmonary Clara cell secretory 10-kd protein (CC10) is a steroid-inducible and potentially anti-inflammatory cytokine, but its direct involvement in the regulation of T-cell responses remains unknown.
  23. ncbi Compensatory roles of Foxa1 and Foxa2 during lung morphogenesis
    Huajing Wan
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center and the University of Cincinnati College of Medicine, Cincinnati, Ohio 45229 3039, USA
    J Biol Chem 280:13809-16. 2005
    ..differentiation, as indicated by lack of expression of surfactant protein B, surfactant protein C, the Clara cell secretory protein, and Foxj1, was inhibited...
  24. ncbi Nmyc plays an essential role during lung development as a dosage-sensitive regulator of progenitor cell proliferation and differentiation
    Tadashi Okubo
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Development 132:1363-74. 2005
    ..We propose a model in which Nmyc is essential in the developing lung for maintaining a distal population of undifferentiated, proliferating progenitor cells...
  25. ncbi Wnt/beta-catenin signaling acts upstream of N-myc, BMP4, and FGF signaling to regulate proximal-distal patterning in the lung
    Weiguo Shu
    Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Dev Biol 283:226-39. 2005
    ..Thus, Wnt/beta-catenin signaling is a critical upstream regulator of proximal-distal patterning in the lung, in part, through regulation of N-myc, BMP4, and FGF signaling...
  26. ncbi Temporal-spatial expression and transcriptional regulation of alpha7 nicotinic acetylcholine receptor by thyroid transcription factor-1 and early growth response factor-1 during murine lung development
    Paul R Reynolds
    Department of Internal Medicine, Pulmonary Division, University of Utah Health Sciences Center, Salt Lake City, 84132, USA
    J Biol Chem 280:32548-54. 2005
    ..From E18.5 to PN20, Clara cells in the bronchiolar epithelium co-expressed Clara cell secretory protein and alpha(7)...
  27. pmc Physical and functional interactions between homeodomain NKX2.1 and winged helix/forkhead FOXA1 in lung epithelial cells
    Parviz Minoo
    Department of Pediatrics, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA
    Mol Cell Biol 27:2155-65. 2007
    ..family of FOXA transcription factors to regulate two spatially and cell type-specific genes, SpC and Ccsp. The results show that NKX2.1 interacts physically and functionally with FOXA1...
  28. pmc Sprouty-2 regulates oncogenic K-ras in lung development and tumorigenesis
    Alice T Shaw
    Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, and Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston 02114, USA
    Genes Dev 21:694-707. 2007
    ..These findings indicate that in the lung, Sprouty-2 plays a critical role in the regulation of oncogenic K-ras, and implicate counter-regulatory mechanisms in the pathogenesis of Ras-based disease...
  29. ncbi Foxp2 and Foxp1 cooperatively regulate lung and esophagus development
    Weiguo Shu
    Cardiovascular Institute, University of Pennsylvania, 956 BRB II III, 421 Curie Blvd, Philadelphia, PA 19104, USA
    Development 134:1991-2000. 2007
    ....
  30. pmc Multiple dose-dependent roles for Sox2 in the patterning and differentiation of anterior foregut endoderm
    Jianwen Que
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Development 134:2521-31. 2007
    ..These findings suggest that Sox2 plays a second role in establishing the boundary between the keratinized, squamous esophagus/forestomach and glandular hindstomach...
  31. pmc Conditional stabilization of beta-catenin expands the pool of lung stem cells
    Susan D Reynolds
    Center for Lung Regeneration, Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Stem Cells 26:1337-46. 2008
    ..Our data demonstrate that the differentiation-modulating activities of stabilized beta-catenin account for expansion of tissue stem cells...
  32. pmc Kruppel-like factor 5 is required for perinatal lung morphogenesis and function
    Huajing Wan
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center and the University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    Development 135:2563-72. 2008
    ..KLF5 regulates genes controlling paracrine interactions during lung morphogenesis, as well as those regulating the maturation of the respiratory epithelium that is required for lung function after birth...
  33. pmc Notch signaling promotes airway mucous metaplasia and inhibits alveolar development
    J Sawalla Guseh
    Department of Stem Cell and Regenerative Biology, Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138, USA
    Development 136:1751-9. 2009
    ..Occasional distal cystic cells appeared to differentiate into normal proximal airway cells, suggesting that ectopic Notch signaling arrests the normal differentiation of distal lung progenitors before they initiate an alveolar program...
  34. pmc The role of Scgb1a1+ Clara cells in the long-term maintenance and repair of lung airway, but not alveolar, epithelium
    Emma L Rawlins
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Cell Stem Cell 4:525-34. 2009
    To directly test the contribution of Scgb1a1(+) Clara cells to postnatal growth, homeostasis, and repair of lung epithelium, we generated a Scgb1a1-CreER "knockin" mouse for lineage-tracing these cells...
  35. pmc Notch signaling controls the balance of ciliated and secretory cell fates in developing airways
    Po Nien Tsao
    Pulmonary Center, Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    Development 136:2297-307. 2009
    ..It might also be relevant to mediate the metaplastic changes in the respiratory epithelium that occur in pathological conditions, such as asthma and chronic obstructive pulmonary disease...
  36. pmc Regulation of TGF-beta signalling by Fbxo11, the gene mutated in the Jeff otitis media mouse mutant
    Hilda Tateossian
    MRC Mammalian Genetics Unit, Harwell, OX11 0RD, UK
    Pathogenetics 2:5. 2009
    ..TGF-beta signalling is involved in a number of epithelial developmental processes and we have investigated the impact of the Jeff mutation on the expression of this pathway...
  37. pmc Mig-6 is required for appropriate lung development and to ensure normal adult lung homeostasis
    Nili Jin
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Development 136:3347-56. 2009
    ..These results demonstrate that Mig-6 is required for prenatal and perinatal lung development, in part through the regulation of EGF signaling, as well as for maintaining proper pulmonary vascularization...
  38. pmc Lunatic Fringe-mediated Notch signaling is required for lung alveogenesis
    Keli Xu
    Program in Developmental and Stem Cell Biology, The Hospital for Sick Children, 101 College St, East Tower, Rm 14 309, Toronto, Ontario, Canada M5G 1L7
    Am J Physiol Lung Cell Mol Physiol 298:L45-56. 2010
    ..In sum, these results demonstrate that Lfng functions to enhance Notch signaling in myofibroblast precursor cells and thereby to coordinate differentiation and mobilization of myofibroblasts required for alveolar septation...
  39. pmc Canonical Notch signaling in the developing lung is required for determination of arterial smooth muscle cells and selection of Clara versus ciliated cell fate
    Mitsuru Morimoto
    Department of Developmental Biology and Division of Dermatology, Washington University School of Medicine, Box 8103, Saint Louis, MO 63110 1095, USA
    J Cell Sci 123:213-24. 2010
    ..These analyses suggest that the impact of gamma-secretase inhibitors on branching in vitro reflect a non-cell autonomous contribution from endothelial or vSMC-derived signals...
  40. pmc Signaling via Alk5 controls the ontogeny of lung Clara cells
    Yiming Xing
    Department of Pediatrics, Division of Neonatology, University of Southern California, Keck School of Medicine, Los Angeles, CA 90033, USA
    Development 137:825-33. 2010
    ..Thus, the signaling pathway by which TGFbeta/ALK5 regulates Clara cell differentiation may entail inhibition of Pten expression, which in turn activates ERK and AKT phosphorylation...
  41. pmc The PCP genes Celsr1 and Vangl2 are required for normal lung branching morphogenesis
    Laura L Yates
    Medical Research Council, Harwell, Oxfordshire OX11 0RD, UK
    Hum Mol Genet 19:2251-67. 2010
    ....
  42. pmc CARM1 is required for proper control of proliferation and differentiation of pulmonary epithelial cells
    Karen B O'Brien
    Harvard Stem Cell Institute and Center for Life Sciences, Harvard Medical School, Boston, MA 02115, USA
    Development 137:2147-56. 2010
    ..These results demonstrate for the first time that CARM1 inhibits pulmonary cell proliferation and is required for proper differentiation of alveolar cells...
  43. pmc A subset of epithelial cells with CCSP promoter activity participates in alveolar development
    Vedang A Londhe
    Department of Pediatrics, Division of Neonatology and Developmental Biology, Neonatal Research Center, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California 90095 1752, USA
    Am J Respir Cell Mol Biol 44:804-12. 2011
    ..Subsets of cells expressing Clara cell secretory protein (CCSP) have been identified in both lung and bone marrow compartments, and are described as a ..
  44. pmc TTF-1 regulates α5 nicotinic acetylcholine receptor (nAChR) subunits in proximal and distal lung epithelium
    Paul R Reynolds
    Department of Physiology and Developmental Biology, Brigham Young University, Provo, UT 84602, USA
    Respir Res 11:175. 2010
    ..5 is a structural subunit detected in many non-neuronal tissues; however, its function during pulmonary development is unknown...
  45. pmc cAMP response element binding protein is required for differentiation of respiratory epithelium during murine development
    A Daniel Bird
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia
    PLoS ONE 6:e17843. 2011
    ..Together, these results demonstrate a crucial role for Creb1 activity for the development and differentiation of the conducting and distal lung epithelium...
  46. pmc Follistatin-like 1 (Fstl1) is a bone morphogenetic protein (BMP) 4 signaling antagonist in controlling mouse lung development
    Yan Geng
    Model Animal Research Center, Nanjing University, Nanjing 210061, China
    Proc Natl Acad Sci U S A 108:7058-63. 2011
    ..Therefore, we provide in vivo and in vitro evidence to demonstrate that Fstl1 modulates lung development and alveolar maturation, in part, through BMP4 signaling...
  47. pmc Wnt/β-catenin signaling accelerates mouse lung tumorigenesis by imposing an embryonic distal progenitor phenotype on lung epithelium
    Eugenia C Pacheco-Pinedo
    Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Clin Invest 121:1935-45. 2011
    ....
  48. pmc Multiple stromal populations contribute to pulmonary fibrosis without evidence for epithelial to mesenchymal transition
    Jason R Rock
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 108:E1475-83. 2011
    ..Similarly, epithelial cells labeled with our Scgb1a1-CreER allele do not give rise to fibroblasts but generate both AEC2 and AEC1 cells in response to bleomycin-..
  49. pmc Neuroepithelial body microenvironment is a niche for a distinct subset of Clara-like precursors in the developing airways
    Arjun Guha
    Pulmonary Center, Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA
    Proc Natl Acad Sci U S A 109:12592-7. 2012
    ..bodies (NEBs), distinguished by their strong Scgb3a2 and uroplakin 3a (Upk3a) signals and reduced Ccsp (Scgb1a1) expression...
  50. pmc Localized Fgf10 expression is not required for lung branching morphogenesis but prevents differentiation of epithelial progenitors
    Thomas Volckaert
    Department of Pediatrics, Division of Cell Biology, National Jewish Health, Denver, CO 80206, USA
    Development 140:3731-42. 2013
    ..Interestingly, our data presented here show that once epithelial cells are committed to the Sox2-positive airway epithelial cell fate, Fgf10 prevents ciliated cell differentiation and promotes basal cell differentiation. ..
  51. ncbi Thyroid transcription factor-1, hepatocyte nuclear factor-3beta, surfactant protein B, C, and Clara cell secretory protein in developing mouse lung
    L Zhou
    Children s Hospital Medical Center, Division of Pulmonary Biology, Cincinnati, Ohio 45229 3039, USA
    J Histochem Cytochem 44:1183-93. 1996
    ..HNF-3beta), prosurfactant proteins B and C (pro-SP-B, pro-SP-C), surfactant protein B (SP-B), and Clara cell secretory protein (CCSP) in developing mouse lung...
  52. ncbi Synergistic transactivation of the differentiation-dependent lung gene Clara cell secretory protein (secretoglobin 1a1) by the basic region leucine zipper factor CCAAT/enhancer-binding protein alpha and the homeodomain factor Nkx2.1/thyroid transcription
    Tobias N Cassel
    Department of Medical Nutrition, Karolinska Institutet, Novum, SE 141 86 Huddinge, Sweden
    J Biol Chem 277:36970-7. 2002
    ..appearance of lung-specific proteins with differentiation-dependent expression patterns, such as the Clara cell secretory protein (secretoglobin 1a1 (Scgb1a1), CCSP)...
  53. ncbi Thyroid transcription factor (TTF) -1 regulates the expression of midkine (MK) during lung morphogenesis
    Paul R Reynolds
    Cincinnati Children s Hospital Medical Center, Division of Pulmonary Biology, Cincinnati, Ohio 45229 3039, USA
    Dev Dyn 227:227-37. 2003
    ..0, MK was restricted to subsets of cells by E18.5, colocalizing with the Clara cell secretory protein (CCSP) marker in conducting airways and with pro-SPC, a marker specific for alveolar type II ..
  54. pmc A Gata6-Wnt pathway required for epithelial stem cell development and airway regeneration
    Yuzhen Zhang
    Department of Medicine, University of Pennsylvania, 956 BRB II III, 421 Curie Boulevard, Philadelphia, Pennsylvania 19104, USA
    Nat Genet 40:862-70. 2008
    ..Together, these data demonstrate that Gata6-regulated Wnt signaling controls the balance between progenitor expansion and epithelial differentiation required for both lung development and regeneration...
  55. pmc Transcription factor Sp3 is essential for post-natal survival and late tooth development
    P Bouwman
    Institut fur Molekularbiologie und Tumorforschung, Emil Mannkopff Strasse 2
    EMBO J 19:655-61. 2000
    ..Comparison of the Sp1 and Sp3 knockout phenotype shows that Sp1 and Sp3 have distinct functions in vivo, but also suggests a degree of functional redundancy...
  56. pmc Prominin 1 marks intestinal stem cells that are susceptible to neoplastic transformation
    Liqin Zhu
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee 38105, USA
    Nature 457:603-7. 2009
    ..Our data indicate that Prom1 marks stem cells in the adult small intestine that are susceptible to transformation into tumours retaining a fraction of mutant Prom1(+) tumour cells...
  57. pmc The expression of osteopontin and its association with Clara cell 10 kDa protein in allergic rhinitis
    Y Liu
    Departments of Otolaryngology Head and Neck Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    Clin Exp Allergy 40:1632-41. 2010
    ..Clara cell 10 kDa protein (CC10) is another protein linked to allergy, and has been suggested to have an inhibitory role in inflammatory airway ..
  58. pmc Expression of B-RAF V600E in type II pneumocytes causes abnormalities in alveolar formation, airspace enlargement and tumor formation in mice
    Emanuele Zanucco
    Department of Molecular Biology, Max Planck Institute of Biochemistry, Martinsried, Germany
    PLoS ONE 6:e29093. 2011
    ..These data support a model where the continuous regenerative process initiated by oncogenic B-RAF-driven alveolar disruption provides a tumor-promoting environment associated with chronic inflammation...
  59. pmc Clara cell 10-kDa protein gene transfection inhibits NF-κB activity in airway epithelial cells
    Xiao Bo Long
    Department of Otolaryngology Head and Neck Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People s Republic of China
    PLoS ONE 7:e35960. 2012
    Clara cell 10-kDa protein (CC10) is a multifunctional protein with anti-inflammatory and immunomodulatory effects. Induction of CC10 expression by gene transfection may possess potential therapeutic effect...
  60. pmc T helper 17 cells play a critical pathogenic role in lung cancer
    Seon Hee Chang
    Departments of Immunology and Pulmonary Medicine, Center for Inflammation and Cancer, The University of Texas MD Anderson Cancer Center, Houston, TX 77054
    Proc Natl Acad Sci U S A 111:5664-9. 2014
    ..frequently found in human lung cancer, is restrictedly expressed in lung epithelial cells [via Clara cell secretory protein (CCSP(cre))]. In this model, Th17 and Treg but not Th1 cells were found enriched at the tumor tissues...
  61. doi Additional sex combs-like family genes are required for normal cardiovascular development
    Andrea L McGinley
    Department of Biological Sciences, University of Illinois at Chicago, Chicago, Illinois
    Genesis 52:671-86. 2014
    ..From these results, we conclude that normal heart development requires both ASXL proteins. In particular, ASXL2 plays an important role in heart morphogenesis and the transition from fetal to postnatal circulation...
  62. doi Insm1 controls the differentiation of pulmonary neuroendocrine cells by repressing Hes1
    Shiqi Jia
    Developmental Biology, Max Delbruck Center for Molecular Medicine, Robert Rossle Strasse 10, 13125 Berlin, Germany
    Dev Biol 408:90-8. 2015
    ..Our work demonstrates that Insm1 is a key factor regulating differentiation of pulmonary neuroendocrine cells. ..
  63. doi Lung development requires an active ERK/MAPK pathway in the lung mesenchyme
    Olivier Boucherat
    Centre de recherche sur le cancer de l Université Laval, CRCHUQ, L Hôtel Dieu de Québec, Quebec, Canada, G1R 3S3
    Dev Dyn 246:72-82. 2017
    ..Considering the negative impact of kyphosis and omphalocele on intrathoracic space and, consequently, on lung growth, the exact role of ERK/MAPK pathway in lung mesenchyme remains unresolved...
  64. pmc Essential roles of ECAT15-2/Dppa2 in functional lung development
    Tomonori Nakamura
    Center for iPS Cell Research and Application CiRA, Kyoto University, Kyoto 606 8507, Japan
    Mol Cell Biol 31:4366-78. 2011
    ..These data suggest that ECAT15-2 has important roles in lung development, where it is no longer expressed, by leaving epigenetic marks from earlier developmental stages...
  65. doi Claudin-3 and Clara cell 10 kDa protein as early signals of cigarette smoke-induced epithelial injury along alveolar ducts
    Snjezana Cuzic
    GlaxoSmithKline Research Centre Zagreb Limited, Zagreb, Croatia
    Toxicol Pathol 40:1169-87. 2012
    ..Claudin-3 and Clara cell 10 kDa protein were identified as possible markers of early tobacco smoke-induced epithelial injury along ADs...
  66. pmc Hypoxia inducible factor 3α plays a critical role in alveolarization and distal epithelial cell differentiation during mouse lung development
    Yadi Huang
    Department of Pediatric Surgery, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
    PLoS ONE 8:e57695. 2013
    ..genes, Rarβ, involved in alveologenesis, and Foxp2, a transcriptional repressor of the Clara cell specific Ccsp gene, were significantly upregulated in the HIF3α expressing lungs...
  67. pmc Regeneration of alveolar type I and II cells from Scgb1a1-expressing cells following severe pulmonary damage induced by bleomycin and influenza
    Dahai Zheng
    Interdisciplinary Research Group in Infectious Diseases, Singapore Massachusetts Institute of Technology Alliance for Research and Technology, Singapore, Singapore
    PLoS ONE 7:e48451. 2012
    ..In this study, we have investigated this issue by using transgenic mice in which Scgb1a1-expressing cells and their progeny can be genetically labeled with EGFP...
  68. pmc Development and regeneration of Sox2+ endoderm progenitors are regulated by a Hdac1/2-Bmp4/Rb1 regulatory pathway
    Yi Wang
    Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Dev Cell 24:345-58. 2013
    ..Thus, Hdac1/2 have both common and unique targets that differentially regulate tissue-specific progenitor activity during development and regeneration...
  69. ncbi cis-acting elements involved in the regulation of mouse Clara cell-specific 10-kDa protein gene. In vitro and in vivo analysis
    M K Ray
    Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030
    J Biol Chem 270:2689-94. 1995
    ....
  70. ncbi Involvement of Sonic hedgehog (Shh) in mouse embryonic lung growth and morphogenesis
    S Bellusci
    Department of Cell Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2175, USA
    Development 124:53-63. 1997
    ..By contrast, Ptc is clearly upregulated in the transgenic lung. These results thus establish a role for SHH in lung morphogenesis, and suggest that SHH normally regulates lung mesenchymal cell proliferation in vivo...
  71. ncbi Sonic hedgehog regulates branching morphogenesis in the mammalian lung
    C V Pepicelli
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Curr Biol 8:1083-6. 1998
    ..In addition, the transcription of several mesenchymally expressed downstream targets of Shh is abolished. These results highlight the importance of epithelially derived Shh in regulating branching morphogenesis of the lung...
  72. ncbi Uteroglobin is essential in preventing immunoglobulin A nephropathy in mice
    F Zheng
    Section on Developmental Genetics, Heritable Disorders Branch, The National Institute of Child Health and Human Development, The National Institutes of Health, Bethesda, Maryland 20892 1830, USA
    Nat Med 5:1018-25. 1999
    ..models (gene knockout and antisense transgenic), both manifesting deficiency of an anti-inflammatory protein, uteroglobin (UG), develop almost all of the pathologic features of human IgA nephropathy...
  73. ncbi HNF-3/forkhead homologue-4 influences lung morphogenesis and respiratory epithelial cell differentiation in vivo
    J W Tichelaar
    Division of Pulmonary Biology, Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Ohio, 45229 3039, USA
    Dev Biol 213:405-17. 1999
    ..However, surfactant proteins SP-B, SP-C, and Clara cell secretory protein, normally produced by nonciliated epithelial cells in lung parenchyma were lacking...
  74. ncbi Repulsive axon guidance molecule Sema3A inhibits branching morphogenesis of fetal mouse lung
    T Ito
    Department of Pathology, Yokohama City University School of Medicine, 3 9 Fuku ura, Kanazawa Ku, 236 0004, Yokohama, Japan
    Mech Dev 97:35-45. 2000
    ..These results provide evidence that Sema3A inhibits branching morphogenesis in lung bud organ cultures via NP-1 as a receptor or a component of a possible multimeric Sema3A receptor complex...
  75. ncbi Attenuation of pulmonary neuroendocrine differentiation in mice lacking Clara cell secretory protein
    C M Castro
    Medicine Branch, National Cancer Institute, National Institutes of Health, Rockville, Maryland, USA
    Lab Invest 80:1533-40. 2000
    During development and injury, pulmonary neuroendocrine (NE) cells may transiently express Clara cell 10 kD protein (CC10), a major product of the nonciliated progenitor cells for normal and neoplastic airway epithelia suggesting a close ..
  76. ncbi Lung hypoplasia and neonatal death in Fgf9-null mice identify this gene as an essential regulator of lung mesenchyme
    J S Colvin
    Department of Molecular Biology and Pharmacology, Washington University Medical School, Campus Box 8103, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Development 128:2095-106. 2001
    ..We suggest a model whereby FGF9 signaling from the epithelium and reciprocal FGF10 signaling from the mesenchyme coordinately regulate epithelial airway branching and organ size during lung embryogenesis...
  77. pmc Sim2 mutants have developmental defects not overlapping with those of Sim1 mutants
    Eleni Goshu
    Department of Embryology, Carnegie Institution of Washington, Baltimore, Maryland 21210, USA
    Mol Cell Biol 22:4147-57. 2002
    ..The temporal and spatial expression patterns of Sim2 in these skeletal elements suggest that Sim2 regulates their growth and/or integrity...
  78. ncbi Role for ETS domain transcription factors Pea3/Erm in mouse lung development
    Yuru Liu
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Dev Biol 261:10-24. 2003
    ..Our results provide the first functional evidence that Pea3 subfamily members play a role in epithelial-mesenchymal interactions during lung organogenesis...
  79. ncbi Timeless in lung morphogenesis
    Jing Xiao
    School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Dev Dyn 228:82-94. 2003
    ..In the proximal airways, TIM was colocalized with CCSP to nonciliated columnar epithelial cells...
  80. ncbi Normal lung development in RAIG1-deficient mice despite unique lung epithelium-specific expression
    Jingsong Xu
    Harvard Medical School, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
    Am J Respir Cell Mol Biol 32:381-7. 2005
    ..Analysis of other family members demonstrated some overlapping embryonic expression of RAIG3 mRNA that could have led to functional redundancy in the single RAIG1 null mutant mouse...
  81. ncbi Uteroglobin inhibits prostaglandin F2alpha receptor-mediated expression of genes critical for the production of pro-inflammatory lipid mediators
    Asim K Mandal
    Section on Developmental Genetics, Heritable Disorders Branch, NICHD, The National Institutes of Health, Bethesda, Maryland 20892 1830, USA
    J Biol Chem 280:32897-904. 2005
    ..inverse relationship exists between the levels of PGF2alpha and a steroid-inducible anti-inflammatory protein, uteroglobin. Here we report that, in NIH 3T3 fibroblasts and human uterine smooth muscle cells, FP signaling is mediated ..
  82. ncbi Loss of Nkx2.8 deregulates progenitor cells in the large airways and leads to dysplasia
    Jianmin Tian
    Department of Pathology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Cancer Res 66:10399-407. 2006
    ..8-/- mice. Increased proliferation and an altered progenitor relationship caused progressive bronchial pathology, which manifested as widespread dysplasia in the large airways of 1-year-old Nkx2.8-/- mice...
  83. pmc E2f4 is required for normal development of the airway epithelium
    Paul S Danielian
    Center for Cancer Research, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Dev Biol 305:564-76. 2007
    ..Importantly, the combination of no ciliated cells and excess mucous cells can account for the chronic rhinitis and increased susceptibility to opportunistic infections that causes the postnatal lethality of E2f4 mutant mice...
  84. pmc Transgenic over-expression of the microRNA miR-17-92 cluster promotes proliferation and inhibits differentiation of lung epithelial progenitor cells
    Yun Lu
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Dev Biol 310:442-53. 2007
    ..Together, these studies suggest that mir-17-92 normally promotes the high proliferation and undifferentiated phenotype of lung epithelial progenitor cells...
  85. doi Systemic inactivation of Hs6st1 in mice is associated with late postnatal mortality without major defects in organogenesis
    Konstantin I Izvolsky
    Pulmonary Center, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Genesis 46:8-18. 2008
    ..Our results suggest a potentially critical role for HS 6-O sulfation by Hs6st1 in postnatal processes...
  86. pmc Cited2 is required for fetal lung maturation
    Bing Xu
    Department of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    Dev Biol 317:95-105. 2008
    ..We propose that the Cited2-Tcfap2c complex controls lung maturation by regulating Cebpa expression. Understanding the function of this complex may provide novel therapeutic strategies for patients with respiratory distress syndromes...
  87. pmc A mouse model for Costello syndrome reveals an Ang II-mediated hypertensive condition
    Alberto J Schuhmacher
    Molecular Oncology Programme, Centro Nacional de Investigaciones Oncologicas, Madrid, Spain
    J Clin Invest 118:2169-79. 2008
    ..In addition, it partially alleviated the observed cardiomyopathies. These mice should help in elucidating the etiology of CS symptoms, identifying additional defects, and evaluating potential therapeutic strategies...
  88. pmc Promotion of lung carcinogenesis by chronic obstructive pulmonary disease-like airway inflammation in a K-ras-induced mouse model
    Seyed Javad Moghaddam
    Department of Pulmonary Medicine, University of Texas M D Anderson Cancer Center, 2121 W Holcombe Boulevard, Suite 703F, Houston, TX 77030, USA
    Am J Respir Cell Mol Biol 40:443-53. 2009
    ..mice harboring the LSL-K-ras(G12D) allele with mice containing Cre recombinase inserted into the Clara cell secretory protein (CCSP) locus, with or without the neomycin cassette excised (CCSP(Cre) and CCSP(Cre-Neo), respectively)...
  89. pmc Bmp2 and Bmp4 genetically interact to support multiple aspects of mouse development including functional heart development
    Takashi Uchimura
    Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA
    Genesis 47:374-84. 2009
    ..These results suggest that the dosage of both BMP2 and 4 is critical for functional heart formation during embryogenesis and after birth...
  90. pmc Truncation of the catalytic domain of the cylindromatosis tumor suppressor impairs lung maturation
    Eirini Trompouki
    Institute of Immunology, Biomedical Sciences Research Center Al Fleming, 34 Al Fleming Str, Vari 16672, Greece
    Neoplasia 11:469-76. 2009
    ..and endothelial structures. Our study identifies an important role of CYLD in lung maturation, which may underlie the development of many cases of lung cancer...
  91. pmc Clara cells attenuate the inflammatory response through regulation of macrophage behavior
    Joshua C Snyder
    Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Am J Respir Cell Mol Biol 42:161-71. 2010
    ..Reduced Clara cell secretory function and corresponding decreases in the abundance of the major Clara cell secretory protein (CCSP) are characteristically seen in these disease states...
  92. pmc Lack of an endogenous anti-inflammatory protein in mice enhances colonization of B16F10 melanoma cells in the lungs
    Arjun Saha
    Section on Developmental Genetics, Program on Developmental Endocrinology and Genetics, Eunice Kennedy Shriver NICHD, National Institutes of Health, Bethesda, Maryland 20892 1830, USA
    J Biol Chem 285:10822-31. 2010
    ..b>Uteroglobin (UG), a potent anti-inflammatory protein, is constitutively expressed in the lungs of virtually all mammals...
  93. doi A systematic expression analysis implicates Plexin-B2 and its ligand Sema4C in the regulation of the vascular and endocrine system
    Matthias Zielonka
    Max Planck Institute for Heart and Lung Research, Department of Pharmacology, Ludwigstr 43, 61231 Bad Nauheim, Germany
    Exp Cell Res 316:2477-86. 2010
    ..This work establishes Plexin-B2 and Sema4C as potential regulators of the vascular and endocrine system and provides an anatomical basis to understand the biological functions of this ligand-receptor pair...
  94. pmc Altered lung morphogenesis, epithelial cell differentiation and mechanics in mice deficient in the Wnt/β-catenin antagonist Chibby
    Damon Love
    Department of Pharmacological Sciences, SUNY at Stony Brook, Stony Brook, New York, United States of America
    PLoS ONE 5:e13600. 2010
    ..Moreover, we demonstrate that Cby is a direct downstream target for the master ciliogenesis transcription factor Foxj1. Collectively, our results demonstrate that Cby facilitates proper postnatal lung development and function...
  95. pmc BMP signaling in the development of the mouse esophagus and forestomach
    Pavel Rodriguez
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Development 137:4171-6. 2010
    ..Together, these findings suggest multiple roles for BMP signaling in the developing esophagus and forestomach...
  96. pmc FOXA1 plays a role in regulating secretoglobin 1a1 expression in the absence of CCAAT/enhancer binding protein activities in lung in vivo
    Taketomo Kido
    Laboratory or Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    Am J Physiol Lung Cell Mol Physiol 300:L441-52. 2011
    ..To determine the in vivo role of C/EBPs in the regulation of SCGB1A1 expression, experiments were performed in which A-C/EBP, a dominant-negative form of C/EBP that interferes with ..
  97. pmc Smad1 and its target gene Wif1 coordinate BMP and Wnt signaling activities to regulate fetal lung development
    Bing Xu
    Developmental Biology and Regenerative Medicine Program, Children s Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, CA 90027, USA
    Development 138:925-35. 2011
    ..This suggests a novel regulatory loop of Bmp4-Smad1-Wif1-Wnt/β-catenin in coordinating BMP and Wnt pathways to control fetal lung development...
  98. pmc ATXN1 protein family and CIC regulate extracellular matrix remodeling and lung alveolarization
    Yoontae Lee
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Dev Cell 21:746-57. 2011
    ..These findings demonstrate a critical role of ATXN1/ATXN1L-CIC complexes in extracellular matrix (ECM) remodeling during development and their potential roles in pathogenesis of disorders affecting ECM remodeling...
  99. ncbi Cell-specific, developmentally and hormonally regulated expression of the rabbit uteroglobin transgene and the endogenous mouse uteroglobin gene in transgenic mice
    A Sandmöller
    Institut fur Molekularbiologie und Tumorforschung, Marburg, F R G
    Mech Dev 34:57-67. 1991
    We have generated a transgenic mouse line by introducing the rabbit uteroglobin gene with 4 kb of 5'-flanking DNA and 1 kb of 3'-flanking DNA into the mouse germ line via microinjection into fertilized oocytes...
  100. ncbi Mouse Clara cell 10-kDa (CC10) protein: cDNA nucleotide sequence and molecular basis for the variation in progesterone binding of CC10 from different species
    G Singh
    Laboratory Service, VA Medical Center, Pittsburgh, PA 15240
    Exp Lung Res 19:67-75. 1993
    ..ability to bind progesterone, and the binding was found to be 27% lower than rat CC10 and 48% lower than rabbit uteroglobin. The relative binding of mouse, rat, and human CC10 may reflect subtle structural perturbations...
  101. ncbi Embryonic mouse lung epithelial progenitor cells co-express immunohistochemical markers of diverse mature cell lineages
    C W Wuenschell
    Center for Craniofacial Molecular Biology, University of Southern California School of Dentistry, Los Angeles, USA
    J Histochem Cytochem 44:113-23. 1996
    ..to study expression in developing mouse lung of calcitonin gene-related peptide (CGRP), Clara cell 10-KD protein (CC10), and surfactant protein-A (SP-A), markers that are differentially expressed in neuroendocrine cells, Clara cells, ..

Research Grants10

  1. Excess TGF beta in neonatal lung injury and repair
    David Warburton; Fiscal Year: 2004
    ..abstract_text> ..
  2. Lung epithelial and vascular morphogenesis
    David Warburton; Fiscal Year: 2006
    ..abstract_text> ..
  3. Na, K-ATPase Regulation by Glucocorticoids in Lung
    Chris Wendt; Fiscal Year: 2007
    ....
  4. AUTOCRINE/PARACRINE GROWTH FACTORS & LUNG MORPHOGENESIS
    David Warburton; Fiscal Year: 2009
    ..Aim 4: To determine the role of tyrosine phosphorylation in protein-protein interaction and supra-molecular assembly of mSPRY2 with SHP2 and FRS2. Aim 5: To determine the functional importance of Shp2 in lung morphogenesis in vivo. ..
  5. Protein Biomarkers in Lung Allograft Rejection
    CHRIS H WENDT; Fiscal Year: 2010
    ..The second is to increase the number of biomarkers for chronic rejection, creating a panel of protein biomarkers that ultimately predicts those with or are at risk for chronic lung transplant rejection. ..
  6. DEVELOPMENTAL TYPE II PNEUMOCYTE PROTEIN PHOSPHORYLATION
    David Warburton; Fiscal Year: 2010
    ..Inosine may function as a low molecular weight therapeutic to ameliorate lung injury, protect lung progenitor cells and hence to promote recovery of the alveolar epithelium from acute injury in both adult and neonate. ..
  7. Interactive Mediators of Injury & Development
    Parviz Minoo; Fiscal Year: 2008
    ..1. ..
  8. Evolutionary studies of mouse seminal fluid protein genes
    ROBERT KARN; Fiscal Year: 2008
    ..Disease research may benefit from studies of selection, since positive selection is often associated with human disease genes. [unreadable] [unreadable] [unreadable]..
  9. Fetal Lung Development:Role of Wnt5a Signaling
    Changgong Li; Fiscal Year: 2008
    ..This information will be of utility in understanding the molecular mechanisms of congenital and induced lung disease. ..
  10. DEVELOPMENTAL LUNG TOXICOLOGY & THE IMMATURE CLARA CELL
    Charles Plopper; Fiscal Year: 2009
    ..This work will further our understanding of the basic molecular mechanisms by which environmental insults are involved in the origins of lung diseases that begin in childhood. ..