Satb2

Summary

Gene Symbol: Satb2
Description: special AT-rich sequence binding protein 2
Alias: mKIAA1034, DNA-binding protein SATB2, KIAA1034-like DNA binding protein, two cut domains-containing homeodomain protein
Species: mouse

Top Publications

  1. ncbi Identification of SATB2 as the cleft palate gene on 2q32-q33
    David R Fitzpatrick
    Cell and Molecualr Genentics, MRC Human Genetics Unit, Western General Hospital, Edinburgh, EH4 2XU, UK
    Hum Mol Genet 12:2491-501. 2003
  2. ncbi Novel transcription factor Satb2 interacts with matrix attachment region DNA elements in a tissue-specific manner and demonstrates cell-type-dependent expression in the developing mouse CNS
    Olga Britanova
    Department of Molecular Biology of Neuronal Signals, Max Planck Institute for Experimental Medicine, 37075 Goettingen, Germany
    Eur J Neurosci 21:658-68. 2005
  3. ncbi SATB2 is a multifunctional determinant of craniofacial patterning and osteoblast differentiation
    Gergana Dobreva
    Max Planck Institute of Immunobiology, Department of Cellular and Molecular Immunology, 79108 Freiburg, Germany
    Cell 125:971-86. 2006
  4. ncbi A novel mode of tangential migration of cortical projection neurons
    Olga Britanova
    Department of Molecular Biology of Neuronal Signals, Max Plank Institute for Experimental Medicine, 37075 Gottingen, Germany
    Dev Biol 298:299-311. 2006
  5. pmc Satb2 haploinsufficiency phenocopies 2q32-q33 deletions, whereas loss suggests a fundamental role in the coordination of jaw development
    Olga Britanova
    Department of Molecular Biology of Neuronal Signals, Max Plank Institute for Experimental Medicine, Goettingen, Germany
    Am J Hum Genet 79:668-78. 2006
  6. pmc A network of genetic repression and derepression specifies projection fates in the developing neocortex
    Karpagam Srinivasan
    Department of Biology, Stanford University, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 109:19071-8. 2012
  7. pmc Examining the relationship between early axon growth and transcription factor expression in the developing cerebral cortex
    Tom Lickiss
    Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK
    J Anat 220:201-11. 2012
  8. doi Satb2 regulates callosal projection neuron identity in the developing cerebral cortex
    ELIZABETH A ALCAMO
    Department of Biology, Stanford University, Stanford, CA 94305, USA
    Neuron 57:364-77. 2008
  9. doi Satb2 is a postmitotic determinant for upper-layer neuron specification in the neocortex
    Olga Britanova
    Max Planck Institute for Experimental Medicine, Hermann Rein Strasse 3, 37075 Gottingen, Germany
    Neuron 57:378-92. 2008
  10. pmc A cross-species analysis of Satb2 expression suggests deep conservation across vertebrate lineages
    Kelly Sheehan-Rooney
    Faculty of Life Sciences and Dental School, Manchester Academic Health Sciences Centre, Michael Smith Building, University of Manchester, Manchester, United Kingdom
    Dev Dyn 239:3481-91. 2010

Scientific Experts

  • Burkhard Schütz
  • Greg Holmes
  • Michael D Wong
  • Nobuko Mori
  • Tom Lickiss
  • Marta Rosario
  • David R Fitzpatrick
  • Pontus C Holm
  • Yanling Wang
  • Kunio Kitamura
  • Michael Piper
  • Kelly Sheehan-Rooney
  • Petrina A Georgala
  • Victor Tarabykin
  • Olga Britanova
  • Rudolf Grosschedl
  • Gergana Dobreva
  • Karpagam Srinivasan
  • Ying Huang
  • Lei Zhang
  • Randal X Moldrich
  • Tanja Vogel
  • Robert Nechanitzky
  • Shen Ju Chou
  • Francois Guillemot
  • Fabio Savarese
  • Susan K McConnell
  • Isabel Farinas
  • Manuela Schwark
  • Nicolas Daviaud
  • Clemens Jaitner
  • Robyn L Kosinsky
  • William L McKenna
  • Andreas Zembrzycki
  • Mikio Shimada
  • Gaia Colasante
  • Gregory A Chinn
  • Arjun Krishnaswamy
  • Peter L Oliver
  • Benedetta Artegiani
  • Yi Huang
  • Sol Katzman
  • Bin Chen
  • Xiaojing Wu
  • Jennifer Betancourt
  • Matthew L Kraushar
  • Srinivas Parthasarathy
  • L Ashley Watson
  • Ryan Insolera
  • Angeliki Louvi
  • Helen R Russell
  • Peter J McKinnon
  • Lisa M Julian
  • Yuko Gonda
  • Ingo Bormuth
  • Eleni Maria Amaniti
  • John N Griffin
  • Joshua R Sanes
  • Jessica M Alsiö
  • Dimitri Cloëtta
  • Tingjia Lu
  • Manuel Eguren
  • Ning Ning Song
  • Steven A Johnsen
  • Yu Qiang Ding
  • Kuo Yan
  • Daijiro Konno
  • Sarah E Ross
  • Dennis D M O'Leary
  • Jyh Ding Wei
  • Silvia Cappello
  • Joanna Pucilowska
  • C Xiang
  • Carlos G Perez-Garcia
  • Margarita Bonilla-Claudio
  • Santos J Franco
  • Sayan Nandi
  • Javier Díaz-Alonso
  • Darren J Yip
  • Youngsoo Lee
  • In Suk Kim
  • Linda J Richards
  • Paola Arlotta
  • Zoltan Molnar
  • Jin Zhang
  • Michele Studer
  • Charles J Billington
  • Simona Lodato
  • Hui Wang
  • Jeremy N Kay

Detail Information

Publications91

  1. ncbi Identification of SATB2 as the cleft palate gene on 2q32-q33
    David R Fitzpatrick
    Cell and Molecualr Genentics, MRC Human Genetics Unit, Western General Hospital, Edinburgh, EH4 2XU, UK
    Hum Mol Genet 12:2491-501. 2003
    ..2q32-q33 that one breakpoint interrupts the transcription unit of the gene encoding the DNA-binding protein SATB2 (formerly KIAA1034)...
  2. ncbi Novel transcription factor Satb2 interacts with matrix attachment region DNA elements in a tissue-specific manner and demonstrates cell-type-dependent expression in the developing mouse CNS
    Olga Britanova
    Department of Molecular Biology of Neuronal Signals, Max Planck Institute for Experimental Medicine, 37075 Goettingen, Germany
    Eur J Neurosci 21:658-68. 2005
    ..We identified a close homologue of Satb1, Satb2, in a cDNA subtraction screening in a search for genes controlling neural differentiation...
  3. ncbi SATB2 is a multifunctional determinant of craniofacial patterning and osteoblast differentiation
    Gergana Dobreva
    Max Planck Institute of Immunobiology, Department of Cellular and Molecular Immunology, 79108 Freiburg, Germany
    Cell 125:971-86. 2006
    ..Here, we show that Satb2, encoding a nuclear matrix protein, is expressed in branchial arches and in cells of the osteoblast lineage...
  4. ncbi A novel mode of tangential migration of cortical projection neurons
    Olga Britanova
    Department of Molecular Biology of Neuronal Signals, Max Plank Institute for Experimental Medicine, 37075 Gottingen, Germany
    Dev Biol 298:299-311. 2006
    ..revealed that these neurons are derived from Emx1+ cortical progenitors and express the transcription factor Satb2 but do not express GABA or Olig1...
  5. pmc Satb2 haploinsufficiency phenocopies 2q32-q33 deletions, whereas loss suggests a fundamental role in the coordination of jaw development
    Olga Britanova
    Department of Molecular Biology of Neuronal Signals, Max Plank Institute for Experimental Medicine, Goettingen, Germany
    Am J Hum Genet 79:668-78. 2006
    The recent identification of SATB2 as a candidate gene responsible for the craniofacial dysmorphologies associated with deletions and translocations at 2q32-q33, one of only three regions of the genome for which haploinsufficiency has ..
  6. pmc A network of genetic repression and derepression specifies projection fates in the developing neocortex
    Karpagam Srinivasan
    Department of Biology, Stanford University, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 109:19071-8. 2012
    Neurons within each layer in the mammalian cortex have stereotypic projections. Four genes-Fezf2, Ctip2, Tbr1, and Satb2-regulate these projection identities...
  7. pmc Examining the relationship between early axon growth and transcription factor expression in the developing cerebral cortex
    Tom Lickiss
    Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK
    J Anat 220:201-11. 2012
    The transcription factors Satb2 (special AT-rich sequence binding protein 2) and Ctip2 (COUP-TF interacting protein 2) have been shown to be required for callosal and corticospinal axon growth respectively from subtypes of cerebral ..
  8. doi Satb2 regulates callosal projection neuron identity in the developing cerebral cortex
    ELIZABETH A ALCAMO
    Department of Biology, Stanford University, Stanford, CA 94305, USA
    Neuron 57:364-77. 2008
    b>Satb2 is a DNA-binding protein that regulates chromatin organization and gene expression. In the developing brain, Satb2 is expressed in cortical neurons that extend axons across the corpus callosum...
  9. doi Satb2 is a postmitotic determinant for upper-layer neuron specification in the neocortex
    Olga Britanova
    Max Planck Institute for Experimental Medicine, Hermann Rein Strasse 3, 37075 Gottingen, Germany
    Neuron 57:378-92. 2008
    ..Here we report that the expression of the AT-rich DNA-binding protein Satb2 defines two subclasses of UL neurons: UL1 (Satb2 positive) and UL2 (Satb2 negative)...
  10. pmc A cross-species analysis of Satb2 expression suggests deep conservation across vertebrate lineages
    Kelly Sheehan-Rooney
    Faculty of Life Sciences and Dental School, Manchester Academic Health Sciences Centre, Michael Smith Building, University of Manchester, Manchester, United Kingdom
    Dev Dyn 239:3481-91. 2010
    Mutation of SATB2 causes cleft palate in humans. To understand the role of SATB2 function in palatogenesis, SATB2 analyses in vertebrate model systems will be essential...
  11. pmc A network connecting Runx2, SATB2, and the miR-23a~27a~24-2 cluster regulates the osteoblast differentiation program
    Mohammad Q Hassan
    Department of Cell Biology and Cancer Center, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Proc Natl Acad Sci U S A 107:19879-84. 2010
    ..biological significance of Runx2 repression of this miR cluster is that each miR directly targets the 3' UTR of SATB2, which is known to synergize with Runx2 to facilitate bone formation...
  12. pmc Satb1 and Satb2 regulate embryonic stem cell differentiation and Nanog expression
    Fabio Savarese
    Max Planck Institute of Immunobiology, Department of Cellular and Molecular Immunology, 79108 Freiburg, Germany
    Genes Dev 23:2625-38. 2009
    Satb1 and the closely related Satb2 proteins regulate gene expression and higher-order chromatin structure of multigene clusters in vivo...
  13. pmc Lhx2 specifies regional fate in Emx1 lineage of telencephalic progenitors generating cerebral cortex
    Shen Ju Chou
    Molecular Neurobiology Laboratory, The Salk Institute, La Jolla, California, USA
    Nat Neurosci 12:1381-9. 2009
    ..These findings establish a genetic mechanism for determining regional-fate in the Emx1 lineage of telencephalic progenitors that generate cerebral cortex...
  14. pmc SUMO modification of a novel MAR-binding protein, SATB2, modulates immunoglobulin mu gene expression
    Gergana Dobreva
    Gene Center and Institute of Biochemistry, University of Munich, Munich 81377, Germany
    Genes Dev 17:3048-61. 2003
    ..Here we characterize a novel cell type-specific MAR-binding protein, SATB2, which binds to the MARs of the endogenous immunoglobulin micro locus in pre-B cells and enhances gene expression...
  15. pmc Transient neuronal populations are required to guide callosal axons: a role for semaphorin 3C
    Mathieu Niquille
    Department of Cellular Biology and Morphology, University of Lausanne, Switzerland
    PLoS Biol 7:e1000230. 2009
    ..By revealing a novel and essential role for these neuronal populations in the pathfinding of a major cerebral commissure, our study brings new perspectives to pathophysiological mechanisms altering CC formation...
  16. pmc Temporally defined neocortical translation and polysome assembly are determined by the RNA-binding protein Hu antigen R
    Matthew L Kraushar
    Department of Neuroscience and Cell Biology, Rutgers University, Robert Wood Johnson Medical School, Piscataway, NJ 08854
    Proc Natl Acad Sci U S A 111:E3815-24. 2014
    ..Our study identifies a crucial role for HuR in neocortical development as a translational gatekeeper for functionally related mRNA subgroups and polysomal protein specificity. ..
  17. pmc Smad-interacting protein-1 (Zfhx1b) acts upstream of Wnt signaling in the mouse hippocampus and controls its formation
    Amaya Miquelajauregui
    Max Planck Institute for Experimental Medicine, Hermann Rein Strasse 3, 37075 Gottingen, Germany
    Proc Natl Acad Sci U S A 104:12919-24. 2007
    ..Sip1 is therefore essential to the development of the hippocampus and dentate gyrus, and is able to modulate Wnt signaling in these regions...
  18. pmc The CSF-1 receptor ligands IL-34 and CSF-1 exhibit distinct developmental brain expression patterns and regulate neural progenitor cell maintenance and maturation
    Sayan Nandi
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, New York, NY 10461, USA
    Dev Biol 367:100-13. 2012
    ..Thus our results also indicate novel roles for the CSF-1R in the regulation of corticogenesis...
  19. pmc Neocortical dendritic complexity is controlled during development by NOMA-GAP-dependent inhibition of Cdc42 and activation of cofilin
    Marta Rosario
    Neurocure Excellence Cluster, Institute of Cell and Neurobiology, Charite Universitatsmedizin Berlin, Germany
    Genes Dev 26:1743-57. 2012
    ..Our findings define a novel cell-intrinsic mechanism to regulate dendritic branching and thus neuronal complexity in the cerebral cortex...
  20. pmc The mammalian DM domain transcription factor Dmrta2 is required for early embryonic development of the cerebral cortex
    Daijiro Konno
    Laboratory for Cell Asymmetry, RIKEN Center for Developmental Biology, Kobe, Hyogo, Japan
    PLoS ONE 7:e46577. 2012
    ....
  21. pmc Nuclear factor one B regulates neural stem cell differentiation and axonal projection of corticofugal neurons
    Jennifer Betancourt
    Department of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, California, 95064
    J Comp Neurol 522:6-35. 2014
    ..Together these results demonstrate the critical functions of NFIB in regulating cortical development...
  22. pmc ARX regulates cortical intermediate progenitor cell expansion and upper layer neuron formation through repression of Cdkn1c
    Gaia Colasante
    Department of Neuroscience, San Raffaele Scientific Institute, Milan 20132, Italy
    Cereb Cortex 25:322-35. 2015
    ..We also identified ARX as a direct regulator of Cdkn1c transcription. Together these data support a model where ARX regulates the expansion of cortical progenitor cells through repression of Cdkn1c. ..
  23. pmc X-linked microtubule-associated protein, Mid1, regulates axon development
    Tingjia Lu
    Institute of Neuroscience and State Key Laboratory of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    Proc Natl Acad Sci U S A 110:19131-6. 2013
    ..Together, these data demonstrate that Mid1-dependent PP2Ac turnover is important for normal axonal development and that dysregulation of this process may contribute to the underlying cause of OS. ..
  24. doi The APC/C cofactor Cdh1 prevents replicative stress and p53-dependent cell death in neural progenitors
    Manuel Eguren
    Cell Division and Cancer Group, Spanish National Cancer Research Centre CNIO, E 28029 Madrid, Spain
    Nat Commun 4:2880. 2013
    ..These data indicate that the inactivation of Cdh1 in vivo results in replicative stress, cell cycle arrest and cell death, supporting recent therapeutic proposals aimed to inhibit the APC/C in tumours. ..
  25. doi A novel function for Foxm1 in interkinetic nuclear migration in the developing telencephalon and anxiety-related behavior
    Xiaojing Wu
    Key Laboratory of Developmental Genes and Human Diseases, Ministry of Education, Department of Anatomy and Neuroscience, Medical School, Southeast University, Nanjing, 210009, China
    J Neurosci 34:1510-22. 2014
    ..Moreover, ablation of Foxm1 causes anxiety-related behaviors in adulthood. Thus, this study provides evidence of linkages among the cell cycle regulator Foxm1, INM, and adult behavior. ..
  26. doi Dual effect of CTCF loss on neuroprogenitor differentiation and survival
    L Ashley Watson
    Departments of Paediatrics and Biochemistry, The University of Western Ontario and Children s Health Research Institute, London, Ontario N6C 2V5, Canada and Medical Genetics Centre Department of Cell Biology and Genetics, Erasmus University, 3000 CA, Rotterdam, The Netherlands
    J Neurosci 34:2860-70. 2014
    ....
  27. pmc Ccm3, a gene associated with cerebral cavernous malformations, is required for neuronal migration
    Angeliki Louvi
    Departments of Neurosurgery and Neurobiology, Yale Program on Neurogenetics, Yale School of Medicine, New Haven, CT 06520, USA
    Development 141:1404-15. 2014
    ..Thus, we identify a novel cytoplasmic regulator of neuronal migration and demonstrate that its inactivation in radial glia progenitors and nascent neurons produces severe malformations of cortical development. ..
  28. pmc Agenesis of the Corpus Callosum Due to Defective Glial Wedge Formation in Lhx2 Mutant Mice
    Gregory A Chinn
    Department of Developmental and Cell Biology, School of Biological Sciences, University of California Irvine, Irvine, CA, USA Department of Pathology and Laboratory Medicine, School of Medicine, University of California Irvine, Irvine, CA, USA
    Cereb Cortex 25:2707-18. 2015
    ..These studies define essential roles for Lhx2 in GW, hippocampal commissure, and corpus callosum formation, and suggest that defects in radial GW progenitors can give rise to ACC. ..
  29. doi Ntf3 acts downstream of Sip1 in cortical postmitotic neurons to control progenitor cell fate through feedback signaling
    Srinivas Parthasarathy
    Institute for Cell and Neurobiology, Center for Anatomy, Charite Universitatsmedizin Berlin, Berlin 10117, Germany Max Planck Institute for Experimental Medicine, Goettingen 37075, Germany
    Development 141:3324-30. 2014
    ..Loss of Ntf3, by contrast, causes an increase in layer VI neurons but does not rescue the Sip1 mutant phenotype, implying that other parallel pathways also control the timing of progenitor cell fate switch...
  30. pmc Robo1 regulates the migration and laminar distribution of upper-layer pyramidal neurons of the cerebral cortex
    Yuko Gonda
    Laboratory for Neocortical Development, RIKEN Center for Developmental Biology, Kobe 650 0047, Japan
    Cereb Cortex 23:1495-508. 2013
    ..These results demonstrate that Robo receptors play a crucial role in neocortical lamination and particularly in the positioning of layers II/III pyramidal neurons...
  31. pmc Disruption of Visc-2, a Brain-Expressed Conserved Long Noncoding RNA, Does Not Elicit an Overt Anatomical or Behavioral Phenotype
    Peter L Oliver
    MRC Functional Genomics Unit Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3QX, UK
    Cereb Cortex 25:3572-85. 2015
    ..A high-throughput knockout program focussing on lncRNAs, similar to that currently underway for protein-coding genes, will be required to establish the distribution of their organismal functions. ..
  32. pmc Satb2-independent acquisition of the cholinergic sudomotor phenotype in rodents
    Burkhard Schütz
    Department of Molecular Neuroscience, Institute of Anatomy and Cell Biology, Philipps University, Robert Koch Straße 8, 35037, Marburg, Germany
    Cell Mol Neurobiol 35:205-16. 2015
    Expression of Satb2 (Special AT-rich sequence-binding protein-2) elicits expression of the vesicular acetylcholine transporter (VAChT) and choline acetyltransferase (ChAT) in cultured rat sympathetic neurons exposed to soluble ..
  33. pmc Cortical neurogenesis in the absence of centrioles
    Ryan Insolera
    1 Developmental Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA 2 Graduate Program in Neuroscience, Weill Cornell Medical College, New York, New York, USA 3
    Nat Neurosci 17:1528-35. 2014
    ..Our findings define the functions of centrioles in anchoring RGPs in the VZ and ensuring their efficient mitoses, and reveal the robust adaptability of RGPs in the developing cortex. ..
  34. pmc BCL11B expression in intramembranous osteogenesis during murine craniofacial suture development
    Greg Holmes
    Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA Electronic address
    Gene Expr Patterns 17:16-25. 2015
    ..BCL11B is expressed to potentially regulate the transition of mesenchymal differentiation and suture formation within craniofacial intramembranous bone...
  35. pmc Tox: a multifunctional transcription factor and novel regulator of mammalian corticogenesis
    Benedetta Artegiani
    DFG Research Center for Regenerative Therapies, Cluster of Excellence, TU Dresden, Dresden, Germany
    EMBO J 34:896-910. 2015
    ..Our data provide a valuable resource to study the role of Tox in other tissues and highlight a novel key player in brain development...
  36. pmc Single-cell-level spatial gene expression in the embryonic neural differentiation niche
    Yi Huang
    Chinese Academy of Sciences Key Laboratory of Computational Biology, Chinese Academy of Sciences Max Planck Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China University of Chinese Academy of Sciences, Beijing 100049, China
    Genome Res 25:570-81. 2015
    ....
  37. pmc Postmitotic regulation of sensory area patterning in the mammalian neocortex by Lhx2
    Andreas Zembrzycki
    Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037 and
    Proc Natl Acad Sci U S A 112:6736-41. 2015
    ..Our results reemphasize critical roles for Lhx2 that acts as one of the terminal selector genes in controlling principal properties of neurons. ..
  38. pmc Sidekick 2 directs formation of a retinal circuit that detects differential motion
    Arjun Krishnaswamy
    Department of Molecular and Cellular Biology and Center for Brain Science, Harvard University, Cambridge, Massachusetts 02138, USA
    Nature 524:466-70. 2015
    ..This non-canonical circuit introduces a delay into the pathway from photoreceptors in the centre of the receptive field to W3B-RGCs, which could improve their ability to judge the synchrony of local and global motion. ..
  39. pmc Polynucleotide kinase-phosphatase enables neurogenesis via multiple DNA repair pathways to maintain genome stability
    Mikio Shimada
    Department of Genetics, St Jude Children s Research Hospital, Memphis, TN, USA
    EMBO J 34:2465-80. 2015
    ..These data illuminate the basis for selective neural vulnerability in DNA repair deficiency disease. ..
  40. pmc Mutual regulation between Satb2 and Fezf2 promotes subcerebral projection neuron identity in the developing cerebral cortex
    William L McKenna
    Department of Molecular, Cell, and Developmental Biology, University of California, Santa Cruz, CA 95064
    Proc Natl Acad Sci U S A 112:11702-7. 2015
    ..It was reported that the special AT-rich sequence-binding protein 2 (Satb2) is required for proper development of callosal neuron identity and represses expression of genes that are ..
  41. pmc Usp22 deficiency impairs intestinal epithelial lineage specification in vivo
    Robyn L Kosinsky
    Department of General, Visceral and Pediatric Surgery, University Medical Center Gottingen, 37075 Gottingen, Germany
    Oncotarget 6:37906-18. 2015
    ..Taken together, we provide evidence for a physiological role for USP22 in controlling cell differentiation and lineage specification...
  42. doi Impaired cortical neurogenesis in plexin-B1 and -B2 double deletion mutant
    Nicolas Daviaud
    Fishberg Department of Neuroscience and Friedman Brain Institute, New York, New York 10029
    Dev Neurobiol 76:882-99. 2016
    ..2015 Wiley Periodicals, Inc. Develop Neurobiol 76: 882-899, 2016. ..
  43. pmc Satb2 determines miRNA expression and long-term memory in the adult central nervous system
    Clemens Jaitner
    Institute for Neuroscience, Medical University of Innsbruck, Innsbruck, Austria
    elife 5:. 2016
    i>SATB2 is a risk locus for schizophrenia and encodes a DNA-binding protein that regulates higher-order chromatin configuration...
  44. pmc Perturbed desmosomal cadherin expression in grainy head-like 1-null mice
    Tomasz Wilanowski
    Rotary Bone Marrow Research Laboratories, Melbourne Health Research Directorate, Royal Melbourne Hospital, Parkville, Victoria, Australia
    EMBO J 27:886-97. 2008
    ....
  45. pmc Mouse inscuteable induces apical-basal spindle orientation to facilitate intermediate progenitor generation in the developing neocortex
    Maria Pia Postiglione
    Institute of Molecular Biotechnology of the Austrian Academy of Sciences IMBA, Dr Bohr Gasse 3 5, 1030 Vienna, Austria
    Neuron 72:269-84. 2011
    ..Our results indicate that the orientation of progenitor cell divisions is important for correct lineage specification in the developing mammalian brain...
  46. pmc The CB(1) cannabinoid receptor drives corticospinal motor neuron differentiation through the Ctip2/Satb2 transcriptional regulation axis
    Javier Díaz-Alonso
    Research Network Center for Biomedical Research in Neurodegenerative Diseases, 28049 Madrid, Spain
    J Neurosci 32:16651-65. 2012
    ..Here we show that the CB(1) receptor, by preventing Satb2 (special AT-rich binding protein 2)-mediated repression, increased Ctip2 (COUP-TF interacting protein 2) promoter ..
  47. pmc Fgf8 dosage determines midfacial integration and polarity within the nasal and optic capsules
    John N Griffin
    Dept of Craniofacial Development, King s College London, Floor 27, Guy s Hospital, London Bridge, London SE1 9RT, UK
    Dev Biol 374:185-97. 2013
    ..Taken together, our data highlight Fgf8 signaling in craniofacial development as a plausible target for evolutionary selective pressures...
  48. doi Neuronal basic helix-loop-helix proteins Neurod2/6 regulate cortical commissure formation before midline interactions
    Ingo Bormuth
    Max Planck Institute of Experimental Medicine, Department of Neurogenetics, D 37075 Gottingen, Germany
    J Neurosci 33:641-51. 2013
    ..Our findings define a new stage in corpus callosum development and demonstrate that neocortical projection neurons require transcriptional specification by neuronal bHLH proteins to execute an intrinsic program of remote connectivity...
  49. pmc Ikaros promotes early-born neuronal fates in the cerebral cortex
    Jessica M Alsiö
    Gurdon Institute and Department of Biochemistry, University of Cambridge, Cambridge CB2 1QN, United Kingdom
    Proc Natl Acad Sci U S A 110:E716-25. 2013
    ..These data suggest that Ikaros plays a similar role in regulating early temporal fates in the mammalian cerebral cortex as Ikaros/Hunchback proteins do in the Drosophila nerve cord...
  50. doi Expression of transcription factor Satb2 in adult mouse brain
    Ying Huang
    Key Laboratory of Arrhythmias, Ministry of Education of China, East Hospital, Tongji University School of Medicine, Shanghai, 200092, China
    Anat Rec (Hoboken) 296:452-61. 2013
    Previous investigations on the expression and function of special AT-rich sequence binding protein 2 (Satb2) are largely limited to the cerebral cortex...
  51. doi Gli3 is required in Emx1+ progenitors for the development of the corpus callosum
    Eleni Maria Amaniti
    Centre for Integrative Physiology, University of Edinburgh, Hugh Robson Building, George Square, Edinburgh EH8 9XD, United Kingdom
    Dev Biol 376:113-24. 2013
    ..Collectively, these data demonstrate a crucial role for Gli3 in cortical progenitors to control CC formation and indicate how defects in CSB formation affect the positioning of callosal guidepost cells...
  52. doi Opposing regulation of Sox2 by cell-cycle effectors E2f3a and E2f3b in neural stem cells
    Lisa M Julian
    Department of Cellular and Molecular Medicine, University of Ottawa, 451 Smyth Road, Ottawa, ON K1H 8M5, Canada
    Cell Stem Cell 12:440-52. 2013
    ..Our results demonstrate a mechanism by which E2f3a and E2f3b differentially regulate Sox2 dosage in neural precursors, a finding that may have broad implications for the regulation of diverse stem cell populations...
  53. doi Inactivation of mTORC1 in the developing brain causes microcephaly and affects gliogenesis
    Dimitri Cloëtta
    Biozentrum, University of Basel, CH 4056 Basel, Switzerland
    J Neurosci 33:7799-810. 2013
    ..Together, our results show that postnatal survival, overall brain growth, and specific aspects of brain development critically depend on mTORC1 function...
  54. pmc A mammalian conserved element derived from SINE displays enhancer properties recapitulating Satb2 expression in early-born callosal projection neurons
    Kensuke Tashiro
    Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Midori ku, Yokohama, Kanagawa, Japan
    PLoS ONE 6:e28497. 2011
    ..Notably, we identified the AS021 SINE locus, located 390 kbp upstream of Satb2. Using transgenic mice, we showed that this SINE displays specific enhancer activity in the developing cerebral ..
  55. pmc Special AT-rich binding protein-2 (SATB2) differentially affects disease-causing p63 mutant proteins
    Jacky Chung
    Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    J Biol Chem 286:40671-80. 2011
    ..that AEC p63 mutations affect the ability of the p63 protein to interact with special AT-rich binding protein-2 (SATB2), which has recently also been implicated in the development of cleft palate...
  56. doi COUP-TFI promotes radial migration and proper morphology of callosal projection neurons by repressing Rnd2 expression
    Christian Alfano
    Telethon Institute of Genetics and Medicine TIGEM, Developmental Disorders Program, 80131 Naples, Italy
    Development 138:4685-97. 2011
    ..Thus, our data demonstrate that COUP-TFI modulates late-born neuron migration and favours proper differentiation of CPNs by finely regulating Rnd2 expression levels...
  57. doi Satb2 is required for dendritic arborization and soma spacing in mouse cerebral cortex
    Lei Zhang
    Department of Anatomy and Neurobiology, Tongji University School of Medicine, Shanghai 200092, China
    Cereb Cortex 22:1510-9. 2012
    ..We reduced Satb2 expression in a population of layer II/III pyramidal neurons in vivo by RNA interference and found that the somas ..
  58. pmc FLRT2 and FLRT3 act as repulsive guidance cues for Unc5-positive neurons
    Satoru Yamagishi
    Department of Molecular Neurobiology, Max Planck Institute of Neurobiology, Am Klopferspitz, Martinsried, Germany
    EMBO J 30:2920-33. 2011
    ..Hence, the shed FLRT2 and FLRT3 ECDs represent a novel family of chemorepellents for Unc5-positive neurons and FLRT2/Unc5D signalling modulates cortical neuron migration...
  59. pmc Molecular regulation of the developing commissural plate
    Randal X Moldrich
    Queensland Brain Institute, University of Queensland, Brisbane, QLD 4072, Australia
    J Comp Neurol 518:3645-61. 2010
    ..such as Emx2 and Nfia knockout mice but commissural plate patterning was normal in other acallosal strains such as Satb2(-/-)...
  60. pmc The generation of superficial cortical layers is regulated by levels of the transcription factor Pax6
    Petrina A Georgala
    Centre for Integrative Physiology, School of Biomedical Sciences, Genes and Development Group, The University of Edinburgh, Edinburgh, UK
    Cereb Cortex 21:81-94. 2011
    ..Our analyses suggest that correct levels of Pax6 are essential for normal production of superficial layers of the cortex...
  61. pmc Snf2l regulates Foxg1-dependent progenitor cell expansion in the developing brain
    Darren J Yip
    Regenerative Medicine Program, Ottawa Hospital Research Institute, and Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, ON, Canada
    Dev Cell 22:871-8. 2012
    ..We demonstrate that Snf2l binds to the Foxg1 locus at midneurogenesis and that the phenotype is rescued by reducing Foxg1 dosage, thus revealing that Snf2l and Foxg1 function antagonistically to regulate brain size...
  62. pmc Bmp signaling regulates a dose-dependent transcriptional program to control facial skeletal development
    Margarita Bonilla-Claudio
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Development 139:709-19. 2012
    ..Chromatin immunoprecipitation (ChIP) revealed a subset of the BIG signature, including Satb2, Smad6, Hand1, Gadd45γ and Gata3, that was bound by Smad1/5 in the developing mandible, revealing direct Smad-..
  63. pmc RP58/ZNF238 directly modulates proneurogenic gene levels and is required for neuronal differentiation and brain expansion
    C Xiang
    The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA
    Cell Death Differ 19:692-702. 2012
    ..Thus, RP58 may act to favor neuronal differentiation and brain growth by coherently repressing multiple proneurogenic genes in a timely manner...
  64. doi Special AT-rich sequence-binding protein 2 and its related genes play key roles in the differentiation of MC3T3-E1 osteoblast like cells
    In Suk Kim
    Department of Orthodontics, Kyung Hee University College of Dental Medicine, Seoul 130 701, Republic of Korea
    Biochem Biophys Res Commun 417:697-703. 2012
    ..In the present study, the differentially expressed genes by SATB2 overexpression were analyzed in MC3T3-E1 osteoblast-like cells using Alizarin red S staining, wound healing assay ..
  65. pmc Bhlhb5 and Prdm8 form a repressor complex involved in neuronal circuit assembly
    Sarah E Ross
    Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA
    Neuron 73:292-303. 2012
    ..These findings suggest that Prdm8 is an obligate partner of Bhlhb5, forming a repressor complex that directs neural circuit assembly in part through the precise regulation of Cadherin-11...
  66. doi A radial glia-specific role of RhoA in double cortex formation
    Silvia Cappello
    Helmholtz Center Munich, German Research Center for Environmental Health, Institute for Stem Cell Research, 85764 Neuherberg, Germany
    Neuron 73:911-24. 2012
    ..These data not only demonstrate that RhoA is largely dispensable for migration in neurons but also showed that defects in radial glial cells, rather than neurons, can be sufficient to produce SBH...
  67. pmc Neurogenesis requires TopBP1 to prevent catastrophic replicative DNA damage in early progenitors
    Youngsoo Lee
    Department of Genetics, St Jude Children s Research Hospital, Memphis, TN, USA
    Nat Neurosci 15:819-26. 2012
    ..Thus, TopBP1 is crucial for maintaining genome integrity in the early progenitors that drive neurogenesis...
  68. doi SATB2 participates in regulation of menadione-induced apoptotic insults to osteoblasts
    Jyh Ding Wei
    Department of Orthopedic Surgery, Shin Kong Wu Ho Su Memorial Hospital, Taipei, Taiwan
    J Orthop Res 30:1058-66. 2012
    Special AT-rich sequence binding protein 2 (SATB2), a nuclear matrix attachment region-binding protein, can regulate embryonic development, cell differentiation, and cell survival...
  69. doi Disrupted ERK signaling during cortical development leads to abnormal progenitor proliferation, neuronal and network excitability and behavior, modeling human neuro-cardio-facial-cutaneous and related syndromes
    Joanna Pucilowska
    Department of Neurosciences, Case Western Reserve University, Cleveland, Ohio 44106 4928, USA
    J Neurosci 32:8663-77. 2012
    ..This study provides a novel mechanistic insight into the basis of cortical malformation which may provide a potential link to cognitive deficits in individuals with altered ERK activity...
  70. doi Ccdc85c encoding a protein at apical junctions of radial glia is disrupted in hemorrhagic hydrocephalus (hhy) mice
    Nobuko Mori
    Department of Biological Science, Graduate School of Science, Osaka Prefecture University, Osaka, Japan
    Am J Pathol 180:314-27. 2012
    ..These findings indicate an important role of Ccdc85C in cortical development and provide a mouse model to study pathogenesis of subcortical heterotopia and hydrocephalus...
  71. pmc Fate-restricted neural progenitors in the mammalian cerebral cortex
    Santos J Franco
    Dorris Neuroscience Center and Department of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 337:746-9. 2012
    ..Because upper cortical layers were expanded during primate evolution, amplification of this RGC pool may have facilitated human brain evolution...
  72. doi Satb1 and Satb2 are dispensable for X chromosome inactivation in mice
    Robert Nechanitzky
    Max Planck Institute of Immunobiology and Epigenetics, Department of Cellular and Molecular Immunology, 79108 Freiburg, Germany
    Dev Cell 23:866-71. 2012
    Satb1 and Satb2 have been recently described as regulators of embryonic stem (ES) cell pluripotency and as silencing factors in X chromosome inactivation...
  73. pmc Multiple non-cell-autonomous defects underlie neocortical callosal dysgenesis in Nfib-deficient mice
    Michael Piper
    Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia
    Neural Dev 4:43. 2009
    ..Therefore, we investigate here how Nfib functions to regulate non-cell-autonomous mechanisms of callosal formation...
  74. doi Facial clefting in Tp63 deficient mice results from altered Bmp4, Fgf8 and Shh signaling
    Helen A Thomason
    Faculty of Medical and Human Sciences, Michael Smith Building, University of Manchester, Oxford Road, Manchester, M13 9PT, England, UK
    Dev Biol 321:273-82. 2008
    ..Our results are consistent with a role for Tp63 in the regulation of Bmp signaling controlling the growth, modelling and fusion events underlying facial development and shed new light on the complex abnormality of facial clefting...
  75. doi Three human ARX mutations cause the lissencephaly-like and mental retardation with epilepsy-like pleiotropic phenotypes in mice
    Kunio Kitamura
    Department of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan
    Hum Mol Genet 18:3708-24. 2009
    ....
  76. pmc Nogo-a regulates neural precursor migration in the embryonic mouse cortex
    Carole Mathis
    Brain Research Institute, University of Zurich and Department of Biology, ETH Zurich, 8057 Zurich, Switzerland
    Cereb Cortex 20:2380-90. 2010
    ..These findings suggest that Nogo-A and its receptor complex play a role in the interplay of adhesive and repulsive cell interactions in radial migration during cortical development...
  77. pmc Af9/Mllt3 interferes with Tbr1 expression through epigenetic modification of histone H3K79 during development of the cerebral cortex
    Nicole Büttner
    Centre of Anatomy, Department of Neuroanatomy, University Medical Centre Goettingen, Georg August University, 37075 Goettingen, Germany
    Proc Natl Acad Sci U S A 107:7042-7. 2010
    ..Thus, this study identified AF9 as a developmental active epigenetic modifier during the generation of cortical projection neurons...
  78. pmc Fgfr2 is required for the development of the medial prefrontal cortex and its connections with limbic circuits
    Hanna E Stevens
    Child Study Center, Yale University, New Haven, Connecticut 06520, USA
    J Neurosci 30:5590-602. 2010
    ..These data demonstrate that FGFR2 signaling expands the number of excitatory neurons in the mPFC and secondarily influences target neurons in subcortical stations of the limbic system...
  79. doi Effects of phenytoin on Satb2 and Hoxa2 gene expressions in mouse embryonic craniofacial tissue
    Xiao Yan Mao
    Cleft Lip and Palate Treatment Center, The Second Affiliated Hospital of Shantou University Medical College, Shantou, China
    Biochem Cell Biol 88:731-5. 2010
    ..The Satb2 gene mutation is associated with cleft palate...
  80. ncbi Loss- and gain-of-function analyses reveal targets of Pax6 in the developing mouse telencephalon
    Pontus C Holm
    Institute for Stem Cell Research, National Research Center for Environment and Health, Ingolstadter Landstrasse 1, D 85764 Neuherberg Munich, Germany
    Mol Cell Neurosci 34:99-119. 2007
    ..In the Pax6-deficient cortex the expression levels of various transcription factors involved in neurogenesis (like Satb2, Nfia, AP-2gamma, NeuroD6, Ngn2, Tbr2, Bhlhb5) and the retinoic acid signalling molecule Rlbp1 were reduced...
  81. pmc MALS-3 regulates polarity and early neurogenesis in the developing cerebral cortex
    Karpagam Srinivasan
    Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
    Development 135:1781-90. 2008
    ..Our results suggest that MALS-3 plays a role in maintaining apicobasal polarity and is required for normal neurogenesis in the developing cortex...
  82. pmc Excitatory projection neuron subtypes control the distribution of local inhibitory interneurons in the cerebral cortex
    Simona Lodato
    Center for Regenerative Medicine and Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Neuron 69:763-79. 2011
    ..These data demonstrate that in the neocortex individual populations of projection neurons cell-extrinsically control the laminar fate of interneurons and the assembly of local inhibitory circuitry...
  83. pmc Roles of SATB2 in osteogenic differentiation and bone regeneration
    Jin Zhang
    Division of Oral Biology, Department of General Dentistry, Tufts University School of Dental Medicine, Boston, Massachusetts 02111, USA
    Tissue Eng Part A 17:1767-76. 2011
    Expressed in branchial arches and osteoblast-lineage cells, special AT-rich sequence-binding protein (SATB2) is responsible for preventing craniofacial abnormalities and defects in osteoblast function...
  84. doi Ephrin Bs are essential components of the Reelin pathway to regulate neuronal migration
    Aycan Sentürk
    Frankfurt Institute for Molecular Life Sciences and Institute of Cell Biology and Neuroscience, Goethe University Frankfurt, Max von Laue Str 9, D 60438, Frankfurt am Main, Germany
    Nature 472:356-60. 2011
    ..Together, our results identify ephrin Bs as essential components of the Reelin receptor/signalling pathway to control neuronal migration during the development of the nervous system...
  85. pmc Gli3 is required for maintenance and fate specification of cortical progenitors
    Hui Wang
    Unit on Developmental Neurogenetics, Program in Genomics of Differentiation, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 31:6440-8. 2011
    ..Moreover, Gli3 is required for maintaining the cortical progenitors in active cell cycle, suggesting that cells may acquire differentiated status as they turn off Gli3 expression during neurogenesis...
  86. pmc The molecular and cellular basis of variable craniofacial phenotypes and their genetic rescue in Twisted gastrulation mutant mice
    Charles J Billington
    Department of Pediatrics, University of Minnesota, Minneapolis, MN 55455 0356, USA
    Dev Biol 355:21-31. 2011
    ..We postulate that variable responses to stress may contribute to variable craniofacial phenotypes by triggering differential expression of genes and variable cellular apoptosis...
  87. pmc Neurod6 expression defines new retinal amacrine cell subtypes and regulates their fate
    Jeremy N Kay
    Center for Brain Science, Harvard University, Cambridge, Massachusetts, USA
    Nat Neurosci 14:965-72. 2011
    ..factors selectively expressed by these subtypes, Neurod6 and special AT-rich-sequence-binding protein 2 (Satb2), regulate a postmitotic cell fate choice between these subtypes...
  88. pmc Osteoblast-specific transcription factor Osterix (Osx) is an upstream regulator of Satb2 during bone formation
    Wanjin Tang
    Bone Research Laboratory, Texas Scottish Rite Hospital for Children, Dallas, Texas 75390, USA
    J Biol Chem 286:32995-3002. 2011
    ..Osx knock-out mice lack bone completely. Satb2 is critical for osteoblast differentiation as a special AT-rich binding transcription factor...
  89. doi Stress-activated protein kinase MKK7 regulates axon elongation in the developing cerebral cortex
    Tokiwa Yamasaki
    Department of Developmental and Regenerative Biology, Medical Research Institute, Tokyo Medical and Dental University, Bunkyo ku, Tokyo 113 8510, Japan
    J Neurosci 31:16872-83. 2011
    ....
  90. pmc The cell-intrinsic requirement of Sox6 for cortical interneuron development
    Renata Batista-Brito
    Smilow Neuroscience Program and the Department of Cell Biology, Smilow Research Building, New York University School of Medicine, 522 First Avenue, New York, NY 10016, USA
    Neuron 63:466-81. 2009
    ..It is, however, necessary for their normal positioning and maturation. As a consequence, the specific removal of Sox6 from this population results in a severe epileptic encephalopathy...
  91. pmc FGF signaling expands embryonic cortical surface area by regulating Notch-dependent neurogenesis
    Brian G Rash
    Yale Child Study Center, Yale University, New Haven, Connecticut 06520, USA
    J Neurosci 31:15604-17. 2011
    ....